CA2731664C - Peptidases couplees par polymere - Google Patents
Peptidases couplees par polymere Download PDFInfo
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- CA2731664C CA2731664C CA2731664A CA2731664A CA2731664C CA 2731664 C CA2731664 C CA 2731664C CA 2731664 A CA2731664 A CA 2731664A CA 2731664 A CA2731664 A CA 2731664A CA 2731664 C CA2731664 C CA 2731664C
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- inhibitor
- peptidase
- polymer
- coagulation
- coupled
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Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne un procédé simple permettant la modification de la spécificité dune peptidase du système hémostatique grâce au couplage de polymères à la peptidase, laquelle occasionne la perte de sa réactivité dans le système hémostatique, mais lui permet de continuer à réagir avec certains inhibiteurs, effecteurs et substrats. Linvention concerne en outre des procédés utilisés pour la détection ou la détermination quantitative des inhibiteurs de la peptidase dans des fluides corporels ou dautres échantillons, ainsi que des procédés pour leur neutralisation et/ou leur élimination à partir de liquides. Enfin, linvention permet lutilisation dune peptidase à couplage polymère en tant que médicament et concerne en outre un dispositif qui utilise une telle peptidase dans lélimination dinhibiteurs de peptidase à partir déchantillons ou de la circulation sanguine dun patient.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10153604.3A EP2316931B1 (fr) | 2009-10-30 | 2010-02-15 | Peptidases couplées par polymère |
| EP10153604.3 | 2010-02-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2731664A1 CA2731664A1 (fr) | 2011-08-15 |
| CA2731664C true CA2731664C (fr) | 2020-03-24 |
Family
ID=44483757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2731664A Active CA2731664C (fr) | 2010-02-15 | 2011-02-14 | Peptidases couplees par polymere |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2731664C (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3971576A1 (fr) | 2020-09-21 | 2022-03-23 | Instrumentation Laboratory Company | Détection et surveillance d'anticoagulants oraux ou d'inhibiteurs de thrombine directs intraveineux dans un échantillon de sang |
-
2011
- 2011-02-14 CA CA2731664A patent/CA2731664C/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2731664A1 (fr) | 2011-08-15 |
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Effective date: 20160113 |