CA2731113A1 - Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure - Google Patents

Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure Download PDF

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Publication number
CA2731113A1
CA2731113A1 CA2731113A CA2731113A CA2731113A1 CA 2731113 A1 CA2731113 A1 CA 2731113A1 CA 2731113 A CA2731113 A CA 2731113A CA 2731113 A CA2731113 A CA 2731113A CA 2731113 A1 CA2731113 A1 CA 2731113A1
Authority
CA
Canada
Prior art keywords
days
neuregulin
peptide
hours
nrg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2731113A
Other languages
English (en)
French (fr)
Inventor
Anthony Caggiano
Anindita Ganguly
Jennifer Iaci
Tom Parry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acorda Therapeutics Inc
Original Assignee
Acorda Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acorda Therapeutics Inc filed Critical Acorda Therapeutics Inc
Publication of CA2731113A1 publication Critical patent/CA2731113A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2731113A 2008-07-17 2009-07-17 Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure Abandoned CA2731113A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13517108P 2008-07-17 2008-07-17
US61/135,171 2008-07-17
PCT/US2009/004130 WO2010030317A2 (en) 2008-07-17 2009-07-17 Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure

Publications (1)

Publication Number Publication Date
CA2731113A1 true CA2731113A1 (en) 2010-03-18

Family

ID=42005671

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2731113A Abandoned CA2731113A1 (en) 2008-07-17 2009-07-17 Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure

Country Status (13)

Country Link
US (5) US20110166068A1 (OSRAM)
EP (3) EP2320933B1 (OSRAM)
JP (5) JP5797112B2 (OSRAM)
CN (3) CN104623633A (OSRAM)
AU (3) AU2009292216B2 (OSRAM)
BR (1) BRPI0916442A2 (OSRAM)
CA (1) CA2731113A1 (OSRAM)
DK (2) DK3338791T3 (OSRAM)
ES (2) ES2763184T3 (OSRAM)
MX (2) MX2011000696A (OSRAM)
PL (2) PL3338791T3 (OSRAM)
RU (4) RU2536938C2 (OSRAM)
WO (1) WO2010030317A2 (OSRAM)

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CN104623633A (zh) 2008-07-17 2015-05-20 阿索尔达治疗公司 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂
RU2501564C2 (ru) 2008-08-15 2013-12-20 Акорда Терапьютикс, Инк. Композиции и способы для лечения во время не острых периодов после неврологического повреждения цнс
EP2808339B1 (en) * 2008-11-28 2017-02-15 Zensun (Shanghai) Science & Technology, Co., Ltd. Neuregulin peptides and their use
CN104984322B (zh) 2009-10-14 2020-09-11 阿寇达医疗有限公司 神经调节蛋白在治疗外周神经损伤中的应用
WO2013053076A1 (en) * 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions and methods for treating heart failure
MX354598B (es) * 2012-03-30 2018-03-12 Acorda Therapeutics Inc Uso de neuregulina para tratar lesion de nervio periferico.
CA2904055A1 (en) * 2013-03-06 2014-09-12 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin or a fragment thereof for treatment or prophylaxis of heart failure
WO2014187342A1 (en) 2013-05-22 2014-11-27 Zensun (Shanghai) Science & Technology, Ltd. Extended Release of Neuregulin for Treating Heart Failure
CN104758922A (zh) 2014-01-03 2015-07-08 上海泽生科技开发有限公司 纽兰格林制剂的配方
CN105561298A (zh) * 2014-10-17 2016-05-11 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
MA42936A (fr) 2015-09-25 2018-08-01 Douglas B Sawyer Procédé de traitement de blessures cardiaques
EP3445386B1 (en) * 2016-04-19 2020-08-26 Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI) Neuregulin for the treatment and/or prevention of tumors of the nervous system
CN110835368A (zh) * 2018-08-15 2020-02-25 上海泽生科技开发股份有限公司 神经调节蛋白多肽片段及其用途
AR121035A1 (es) 2019-04-01 2022-04-13 Lilly Co Eli Compuestos de neuregulina-4 y métodos de uso
EP4032901A4 (en) * 2019-09-16 2023-10-25 Zensun (Shanghai) Science & Technology, Co., Ltd. RECOMBINANT HUMAN NEUREGULIN DERIVATIVES AND THEIR USE
WO2023070078A1 (en) * 2021-10-22 2023-04-27 The Research Institute At Nationwide Children's Hospital Neuregulin for protection against respiratory viral infection and post-viral disease

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US5716930A (en) 1991-04-10 1998-02-10 Ludwig Institute For Cancer Research Glial growth factors
US5530109A (en) 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
US7037888B1 (en) 1992-04-03 2006-05-02 Acorda Therapeutics, Inc. Methods for treating muscle diseases and disorders
US6087323A (en) 1992-04-03 2000-07-11 Cambridge Neuroscience, Inc. Use of neuregulins as modulators of cellular communication
US5811098A (en) * 1992-11-24 1998-09-22 Bristol-Myers Squibb Company Antibodies to HER4, human receptor tyrosine kinase
US5912326A (en) 1995-09-08 1999-06-15 President And Fellows Of Harvard College Cerebellum-derived growth factors
US6136558A (en) * 1997-02-10 2000-10-24 Genentech, Inc. Heregulin variants
US6051401A (en) 1998-07-28 2000-04-18 Bayer Corporation Methods and constructs for protein expression
SI1115417T1 (sl) 1998-09-25 2006-08-31 Cubist Pharm Inc Uporaba daptomicina
AUPP785098A0 (en) * 1998-12-21 1999-01-21 Victor Chang Cardiac Research Institute, The Treatment of heart disease
US6635249B1 (en) * 1999-04-23 2003-10-21 Cenes Pharmaceuticals, Inc. Methods for treating congestive heart failure
CN1138785C (zh) * 1999-06-04 2004-02-18 周明东 生长因子神经调节蛋白及其类似物的新应用
EP1267913A2 (en) 1999-11-12 2003-01-02 EntreMed, Inc. Methods for administration of therapeutic agents on an antiangiogenic schedule
IL153052A0 (en) 2000-05-23 2003-06-24 Cenes Pharmaceuticals Inc Nrg-2 nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
CU23157A1 (es) * 2001-01-03 2006-07-18 Ct Ingenieria Genetica Biotech COMPOSICION FARMACéUTICA PARA EL TRATAMIENTO DEL DANO TISULAR DEBIDO A FALTA DE IRRIGACION SANGUINEA ARTERIAL
WO2003061571A2 (en) 2002-01-18 2003-07-31 Chiron Corporation Combination il-2/anti-herz antibody therapy for cancers characterized by overexpression of the her2 receptor protein
AU2002304965A1 (en) * 2002-05-24 2003-12-12 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
WO2006087419A2 (en) * 2005-02-18 2006-08-24 Orion Corporation A method for administering levosimendan
AU2006227879A1 (en) 2005-03-23 2006-09-28 Pfizer Products Inc. Therapy of prostate cancer with CTLA4 antibodies and hormonal therapy
US7776817B2 (en) 2005-09-02 2010-08-17 Morehouse School Of Medicine Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue and as regulators of neuronal stem cell migration
US20070213264A1 (en) * 2005-12-02 2007-09-13 Mingdong Zhou Neuregulin variants and methods of screening and using thereof
US20070190127A1 (en) * 2005-12-30 2007-08-16 Mingdong Zhou Extended release of neuregulin for improved cardiac function
EP2262527B1 (en) 2008-02-29 2016-08-03 Acorda Therapeutics, Inc. Compositions for achieving desired glial growth factor 2 plasma levels
CN104623633A (zh) 2008-07-17 2015-05-20 阿索尔达治疗公司 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂
CN104984322B (zh) 2009-10-14 2020-09-11 阿寇达医疗有限公司 神经调节蛋白在治疗外周神经损伤中的应用
WO2012021818A2 (en) 2010-08-13 2012-02-16 Georgetown University Ggf2 and methods of use
MX354598B (es) 2012-03-30 2018-03-12 Acorda Therapeutics Inc Uso de neuregulina para tratar lesion de nervio periferico.

Also Published As

Publication number Publication date
US20160113999A1 (en) 2016-04-28
CN107019794B (zh) 2021-03-12
JP2015129137A (ja) 2015-07-16
JP5797112B2 (ja) 2015-10-21
US20180280477A1 (en) 2018-10-04
AU2015202877A1 (en) 2015-06-18
US20130324466A1 (en) 2013-12-05
RU2011105821A (ru) 2012-08-27
AU2009292216A1 (en) 2010-03-18
PL2320933T3 (pl) 2018-07-31
US11235031B2 (en) 2022-02-01
CN104623633A (zh) 2015-05-20
AU2017203528A1 (en) 2017-06-15
US9956266B2 (en) 2018-05-01
DK2320933T3 (en) 2018-04-16
ES2763184T3 (es) 2020-05-27
JP2022023208A (ja) 2022-02-07
PL3338791T3 (pl) 2020-04-30
JP2019196370A (ja) 2019-11-14
CN102159236A (zh) 2011-08-17
HK1256637A1 (en) 2019-09-27
EP2320933A1 (en) 2011-05-18
EP3338791A1 (en) 2018-06-27
JP2017200949A (ja) 2017-11-09
EP3338791B1 (en) 2019-09-18
RU2020111236A3 (OSRAM) 2021-09-21
CN107019794A (zh) 2017-08-08
EP3632459A1 (en) 2020-04-08
JP6189879B2 (ja) 2017-08-30
WO2010030317A2 (en) 2010-03-18
RU2536938C2 (ru) 2014-12-27
AU2009292216B2 (en) 2015-03-05
RU2698090C2 (ru) 2019-08-22
JP2011528353A (ja) 2011-11-17
RU2020111236A (ru) 2021-09-21
RU2719199C1 (ru) 2020-04-17
ES2664394T3 (es) 2018-04-19
DK3338791T3 (da) 2019-12-16
RU2014141514A (ru) 2016-05-10
EP2320933A4 (en) 2013-02-27
EP2320933B1 (en) 2017-12-27
US20110166068A1 (en) 2011-07-07
MX2011000696A (es) 2011-07-29
MX384378B (es) 2025-03-14
BRPI0916442A2 (pt) 2018-06-19
US20200009228A1 (en) 2020-01-09
US9198951B2 (en) 2015-12-01
AU2015202877B2 (en) 2017-03-09

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140709

EEER Examination request

Effective date: 20140709

EEER Examination request

Effective date: 20140709

FZDE Discontinued

Effective date: 20230728