CA2730257A1 - 2-methylene-19,26-dinor-(20s,22e,25r)-vitamin d analogs - Google Patents
2-methylene-19,26-dinor-(20s,22e,25r)-vitamin d analogs Download PDFInfo
- Publication number
- CA2730257A1 CA2730257A1 CA2730257A CA2730257A CA2730257A1 CA 2730257 A1 CA2730257 A1 CA 2730257A1 CA 2730257 A CA2730257 A CA 2730257A CA 2730257 A CA2730257 A CA 2730257A CA 2730257 A1 CA2730257 A1 CA 2730257A1
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- methylene
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Classifications
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- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
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Landscapes
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- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/171,120 US8399439B2 (en) | 2008-07-10 | 2008-07-10 | 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs |
| US12/171,120 | 2008-07-10 | ||
| PCT/US2009/050106 WO2010006169A2 (en) | 2008-07-10 | 2009-07-09 | 2-methylene-19, 26-dinor-(20s, 22e, 25r)-vitamin d analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2730257A1 true CA2730257A1 (en) | 2010-01-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2730257A Abandoned CA2730257A1 (en) | 2008-07-10 | 2009-07-09 | 2-methylene-19,26-dinor-(20s,22e,25r)-vitamin d analogs |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8399439B2 (enExample) |
| EP (1) | EP2315745A2 (enExample) |
| JP (1) | JP2011527699A (enExample) |
| AU (1) | AU2009268505B2 (enExample) |
| CA (1) | CA2730257A1 (enExample) |
| WO (1) | WO2010006169A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8575136B2 (en) * | 2006-04-06 | 2013-11-05 | Wisconsin Alumni Research Foundation | 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| US20110237557A1 (en) * | 2010-03-23 | 2011-09-29 | Deluca Hector F | Diastereomers of 2-methylene-19-nor-22-methyl-1alpha,25-dihydroxyvitamin d3 |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| US8604009B2 (en) * | 2010-03-23 | 2013-12-10 | Wisconsin Alumni Research Foundation | (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3 |
| CA2824870C (en) * | 2011-06-14 | 2018-08-14 | Wisconsin Alumni Research Foundation | 3-desoxy-2-methylene-19-nor-vitamin d analogs and their uses |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| GB9214202D0 (en) * | 1992-07-03 | 1992-08-12 | Leo Pharm Prod Ltd | Chemical compounds |
| JP2898882B2 (ja) * | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物 |
| DK0717034T3 (da) * | 1994-12-14 | 1999-10-18 | Duphar Int Res | Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| GB9721156D0 (en) * | 1997-10-06 | 1997-12-03 | Leo Pharm Prod Ltd | Novel vitamin d analogues |
| AU7544501A (en) * | 2000-09-08 | 2002-03-22 | Wisconsin Alumni Res Found | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| NZ545862A (en) * | 2003-08-20 | 2010-01-29 | Wisconsin Alumni Res Found | 2-Methylene-19-nor-vitamin D2 compounds |
| WO2005051323A2 (en) * | 2003-11-25 | 2005-06-09 | Wisconsin Alumni Research Foundation | Vitamin d analogs for obesity prevention and treatment |
| DE602005021245D1 (de) * | 2004-11-22 | 2010-06-24 | Wisconsin Alumni Res Found | 2-methylen-19,26,27-trinor-(20s)-1-alpha-hydroxyvitamin d3 and dessen verwendungen |
| WO2006057884A2 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2α-METHYL AND 2ß-METHYL ANALOGS OF 19,26,27-TRINOR-(20S)-1α-HYDROXYVITAMIN D3 AND THEIR USES |
| AU2005309804B9 (en) * | 2004-11-22 | 2011-12-08 | Wisconsin Alumni Research Foundation | 2alpha-methyl-19-nor-(20S)-1alpha-hydroxy-bishomopregnacalciferol and its uses |
| US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| US7803789B2 (en) * | 2006-02-02 | 2010-09-28 | Wisconsin Alumni Research Foundation | Vitamin D analog—RAK, methods and uses thereof |
| JP2009532460A (ja) | 2006-04-06 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−置換−１α，２５−ジヒドロキシ−１９，２６，２７−トリノルビタミンＤ類縁体およびその使用 |
| JP2010504994A (ja) | 2006-09-28 | 2010-02-18 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−（２０ｓ，２５ｓ）−１９，２７−ジノル−（２２ｅ）−ビタミンｄ類縁体 |
| AU2007300214A1 (en) * | 2006-09-28 | 2008-04-03 | Wisconsin Alumni Research Foundation | 2-methylene-(20R,25S)-19,27-dinor-(22E)-vitamin D analogs |
| EP2240440A2 (en) * | 2007-12-28 | 2010-10-20 | Wisconsin Alumni Research Foundation | 2-methylene-(20s,25s)-19,26-dinor-vitamin d analogs |
-
2008
- 2008-07-10 US US12/171,120 patent/US8399439B2/en not_active Expired - Fee Related
-
2009
- 2009-07-09 AU AU2009268505A patent/AU2009268505B2/en not_active Ceased
- 2009-07-09 EP EP09790222A patent/EP2315745A2/en not_active Withdrawn
- 2009-07-09 JP JP2011517621A patent/JP2011527699A/ja active Pending
- 2009-07-09 WO PCT/US2009/050106 patent/WO2010006169A2/en not_active Ceased
- 2009-07-09 CA CA2730257A patent/CA2730257A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010006169A2 (en) | 2010-01-14 |
| WO2010006169A3 (en) | 2010-04-15 |
| US20100009947A1 (en) | 2010-01-14 |
| AU2009268505A1 (en) | 2010-01-14 |
| JP2011527699A (ja) | 2011-11-04 |
| US8399439B2 (en) | 2013-03-19 |
| EP2315745A2 (en) | 2011-05-04 |
| AU2009268505B2 (en) | 2014-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20150709 |