CA2724132C - Amplification system with spatial separation - Google Patents
Amplification system with spatial separation Download PDFInfo
- Publication number
- CA2724132C CA2724132C CA2724132A CA2724132A CA2724132C CA 2724132 C CA2724132 C CA 2724132C CA 2724132 A CA2724132 A CA 2724132A CA 2724132 A CA2724132 A CA 2724132A CA 2724132 C CA2724132 C CA 2724132C
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- analyte
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- sample
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- 238000000926 separation method Methods 0.000 title claims description 68
- 238000003199 nucleic acid amplification method Methods 0.000 title claims description 46
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- 238000000034 method Methods 0.000 claims description 176
- 238000012545 processing Methods 0.000 claims description 126
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- 108020004707 nucleic acids Proteins 0.000 abstract description 36
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
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- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/028—Modular arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/141—Preventing contamination, tampering
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0275—Interchangeable or disposable dispensing tips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/54—Supports specially adapted for pipettes and burettes
- B01L9/543—Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00277—Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00326—Analysers with modular structure
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Robotics (AREA)
- Clinical Laboratory Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09178713.5 | 2009-12-10 | ||
| EP09178713 | 2009-12-10 | ||
| EP10158862.2 | 2010-03-31 | ||
| EP10158862 | 2010-03-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2724132A1 CA2724132A1 (en) | 2011-06-10 |
| CA2724132C true CA2724132C (en) | 2018-03-06 |
Family
ID=43718406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2724132A Active CA2724132C (en) | 2009-12-10 | 2010-12-07 | Amplification system with spatial separation |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8530229B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2333559B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5872765B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102141572B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2724132C (cg-RX-API-DMAC7.html) |
| DE (1) | DE102010053913A1 (cg-RX-API-DMAC7.html) |
| FR (2) | FR2953932B1 (cg-RX-API-DMAC7.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5680950B2 (ja) * | 2009-12-10 | 2015-03-04 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | マルチウェル・プレート及び蓋体 |
| CA2724132C (en) * | 2009-12-10 | 2018-03-06 | F. Hoffmann-La Roche Ag | Amplification system with spatial separation |
| US9744535B2 (en) * | 2010-04-19 | 2017-08-29 | Roche Molecular Systems, Inc. | Cassette with multiwell plates |
| EP2607904B1 (en) * | 2011-12-21 | 2020-01-15 | Roche Diagnostics GmbH | Method for disposing of a liquid within an automated analytical system, tip rack assembly and analytical system |
| FR2999012B1 (fr) * | 2012-11-30 | 2017-12-15 | Primadiag S A S | Module d'attraction magnetique, robot comprenant un tel module, et procede d'utilisation sur billes magnetiques d'un tel module ou d'un tel robot |
| EP2789389B1 (de) | 2013-04-12 | 2015-07-29 | Eppendorf Ag | Vorrichtung zum Bereitstellen von Pipettenspitzen |
| CH708139A2 (de) * | 2013-06-06 | 2014-12-15 | Tecan Trading Ag | Pipettiervorrichtung. |
| CN104786028B (zh) * | 2014-01-21 | 2017-09-22 | 林顺安 | 微孔板组装设备和组装方法 |
| EP2929939A1 (en) * | 2014-04-07 | 2015-10-14 | Yantai AusBio Laboratories Co., Ltd. | Microplate |
| US9835640B2 (en) | 2015-02-13 | 2017-12-05 | Abbott Laboratories | Automated storage modules for diagnostic analyzer liquids and related systems and methods |
| EP3991848A3 (en) * | 2015-04-06 | 2022-07-20 | Meso Scale Technologies, LLC. | High throughput system for performing assays using electrochemiluminescence including a consumable shaking apparatus |
| EP3088306A1 (en) * | 2015-04-27 | 2016-11-02 | Roche Diagniostics GmbH | Recapper, laboratory automation system and method of recapping a sample container |
| WO2017143182A2 (en) | 2016-02-17 | 2017-08-24 | Becton, Dickinson And Company | Automated sample preparation system for diagnostic testing of same |
| CN105628687B (zh) * | 2016-02-24 | 2018-08-07 | 南京诺尔曼生物技术有限公司 | 一种全自动化学发光测定仪 |
| EP4336189A3 (en) * | 2016-04-22 | 2025-03-26 | Becton, Dickinson and Company | Automated diagnostic analyzer and method for its operation |
| JP7111622B2 (ja) * | 2016-04-22 | 2022-08-02 | ベクトン・ディキンソン・アンド・カンパニー | 自動化された診断アナライザおよびその動作のための方法 |
| ES2715518B2 (es) * | 2016-11-11 | 2020-07-14 | Brio Apps Alphasip S L | Sistema para llevar a cabo procedimientos quimicos, biologicos y/o medicos |
| EP3574111A4 (en) * | 2017-01-26 | 2020-12-16 | Bio-Rad Laboratories, Inc. | Assay performance systems including aqueous sample stabilization |
| CN106984066A (zh) * | 2017-06-06 | 2017-07-28 | 利穗科技(苏州)有限公司 | 一种层析柱维护柱架 |
| US11366133B2 (en) * | 2017-10-23 | 2022-06-21 | Shimadzu Corporation | Sample plate and auto-sampler |
| USD886321S1 (en) * | 2018-01-19 | 2020-06-02 | Biotix, Inc. | Pipette tip rack assembly |
| WO2019169347A1 (en) | 2018-03-02 | 2019-09-06 | 10X Genomics, Inc. | Systems and apparatus for holding plates |
| JP6694486B2 (ja) | 2018-03-29 | 2020-05-13 | バイオティクス， インコーポレイテッド | 剛性を高められたピペットチップトレイ |
| USD888280S1 (en) | 2018-03-29 | 2020-06-23 | Biotix, Inc. | Pipette tip tray |
| USD923816S1 (en) | 2019-03-20 | 2021-06-29 | Biotix, Inc. | Pipette tip tray |
| EP3987293A1 (en) * | 2019-06-19 | 2022-04-27 | Life Technologies Corporation | Reagent container and methods of use |
| DE102020126552A1 (de) * | 2020-10-09 | 2022-04-14 | Syntegon Technology Gmbh | Nestausheber und Sterilkammer |
| US11878304B2 (en) * | 2020-12-23 | 2024-01-23 | Tecan Trading Ag | Receiving frame for receiving a support plate for pipette tips |
| US11701663B2 (en) * | 2021-06-28 | 2023-07-18 | Xcaliber Sciences, Inc. | Pipette tip system |
| CN117957448A (zh) * | 2021-09-07 | 2024-04-30 | 贝克顿·迪金森公司 | 用于自动化诊断分析仪中的库存处理的设备和方法 |
| USD1066739S1 (en) * | 2021-09-28 | 2025-03-11 | Xcaliber Sciences, Inc. | Pipette tip storage assembly |
| CN114570450B (zh) * | 2022-03-04 | 2025-11-11 | 莱杰生物科技(苏州)有限公司 | 一种叠装有吸头架的空心盒体 |
| WO2024163768A2 (en) * | 2023-02-03 | 2024-08-08 | Somalogic Operating Co., Inc. | Systems and methods for magnetically separating mixtures |
| USD1068109S1 (en) * | 2023-07-11 | 2025-03-25 | Xcaliber Sciences, Inc. | Pipette tip storage assembly |
| USD1067463S1 (en) * | 2023-07-11 | 2025-03-18 | Xcaliber Sciences, Inc. | Pipette tip storage assembly |
| DE102024101354A1 (de) * | 2024-01-17 | 2025-07-17 | Hamilton Bonaduz Ag | Pipettier-Labormodul mit besonderer Beschickung der Pipettiervorrichtung des Pipettier-Labormoduls |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69841255D1 (de) * | 1997-11-14 | 2009-12-03 | Gen Probe Inc | Arbeitsgerät zur Analyse |
| AU765623B2 (en) * | 1998-05-01 | 2003-09-25 | Gen-Probe Incorporated | Automated process for isolating and amplifying a target nucleic acid sequence |
| WO2000023782A2 (en) * | 1998-10-16 | 2000-04-27 | Intelligent Automation Systems | Continuous processing automated workstation |
| US5984844A (en) * | 1998-10-21 | 1999-11-16 | Royer; Marc A. | Portable exercise device |
| JP2003529056A (ja) * | 2000-02-22 | 2003-09-30 | ジェノスペクトラ，インコーポレイティド | マイクロアレイ作製技術及び装置 |
| US6705242B2 (en) * | 2002-01-08 | 2004-03-16 | Ch2M Hill Constructors, Inc. | Method and apparatus for hermetically sealing openings of an explosion containment chamber |
| GB0227765D0 (en) * | 2002-11-28 | 2003-01-08 | Secr Defence | Apparatus for processing a fluid sample |
| WO2005009202A2 (en) * | 2003-05-12 | 2005-02-03 | Isis Pharmaceuticals, Inc. | Automatic identification of bioagents |
| US20050226771A1 (en) * | 2003-09-19 | 2005-10-13 | Lehto Dennis A | High speed microplate transfer |
| JP4756835B2 (ja) * | 2004-07-14 | 2011-08-24 | キヤノン株式会社 | 生化学反応カートリッジ |
| DE102004036063A1 (de) * | 2004-07-24 | 2006-02-16 | Krones Ag | Vorrichtung und Verfahren zur Plasmabeschichtung/Sterilisation |
| AU2006226992A1 (en) * | 2005-03-22 | 2006-09-28 | Irm Llc | Compound profiling devices, systems, and related methods |
| EP1929269A2 (en) * | 2005-09-30 | 2008-06-11 | Caliper Life Sciences, Inc. | Microfluidic device for purifying a biological component using magnetic beads |
| CA2635268C (en) * | 2006-01-18 | 2021-02-16 | Argos Therapeutics, Inc. | Systems and methods for processing samples in a closed container, and related devices |
| JP2008170332A (ja) * | 2007-01-12 | 2008-07-24 | Anritsu Sanki System Co Ltd | 分注装置 |
| JP2009222634A (ja) * | 2008-03-18 | 2009-10-01 | Panasonic Corp | マイクロプレートの処理装置 |
| JP2011516075A (ja) * | 2008-04-09 | 2011-05-26 | バイオニア コーポレーション | 自動精製装置、マルチウェルプレートキット及び生物学的試料からヘキサンを抽出する方法 |
| CA2724132C (en) * | 2009-12-10 | 2018-03-06 | F. Hoffmann-La Roche Ag | Amplification system with spatial separation |
-
2010
- 2010-12-07 CA CA2724132A patent/CA2724132C/en active Active
- 2010-12-07 JP JP2010272532A patent/JP5872765B2/ja active Active
- 2010-12-09 CN CN201010586630.3A patent/CN102141572B/zh active Active
- 2010-12-09 DE DE102010053913A patent/DE102010053913A1/de not_active Withdrawn
- 2010-12-09 US US12/964,387 patent/US8530229B2/en active Active
- 2010-12-09 EP EP10194256.3A patent/EP2333559B1/en active Active
- 2010-12-09 FR FR1060289A patent/FR2953932B1/fr active Active
-
2013
- 2013-08-08 US US13/962,824 patent/US9365895B2/en active Active
- 2013-08-08 US US13/962,818 patent/US8809039B2/en active Active
-
2015
- 2015-04-10 FR FR1553101A patent/FR3020140B1/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20110306053A1 (en) | 2011-12-15 |
| US8530229B2 (en) | 2013-09-10 |
| EP2333559A1 (en) | 2011-06-15 |
| US9365895B2 (en) | 2016-06-14 |
| JP5872765B2 (ja) | 2016-03-01 |
| CN102141572A (zh) | 2011-08-03 |
| JP2011123067A (ja) | 2011-06-23 |
| FR3020140B1 (fr) | 2019-12-27 |
| FR2953932A1 (fr) | 2011-06-17 |
| EP2333559B1 (en) | 2021-01-27 |
| FR2953932B1 (fr) | 2015-05-22 |
| US20130323741A1 (en) | 2013-12-05 |
| US8809039B2 (en) | 2014-08-19 |
| DE102010053913A1 (de) | 2011-12-15 |
| US20130323826A1 (en) | 2013-12-05 |
| CN102141572B (zh) | 2015-11-25 |
| CA2724132A1 (en) | 2011-06-10 |
| FR3020140A1 (cg-RX-API-DMAC7.html) | 2015-10-23 |
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