CA2712991A1 - Up-regulation of fibroblast growth factor 2 (fgf2) gene expression in living cells with the application of specific and selective electric and electromagnetic fields - Google Patents

Up-regulation of fibroblast growth factor 2 (fgf2) gene expression in living cells with the application of specific and selective electric and electromagnetic fields Download PDF

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Publication number
CA2712991A1
CA2712991A1 CA2712991A CA2712991A CA2712991A1 CA 2712991 A1 CA2712991 A1 CA 2712991A1 CA 2712991 A CA2712991 A CA 2712991A CA 2712991 A CA2712991 A CA 2712991A CA 2712991 A1 CA2712991 A1 CA 2712991A1
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CA
Canada
Prior art keywords
fgf
specific
selective
signal
field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2712991A
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English (en)
French (fr)
Inventor
Carl T. Brighton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2712991A1 publication Critical patent/CA2712991A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2712991A 2008-02-08 2009-02-03 Up-regulation of fibroblast growth factor 2 (fgf2) gene expression in living cells with the application of specific and selective electric and electromagnetic fields Abandoned CA2712991A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/028,530 2008-02-08
US12/028,530 US7981611B2 (en) 2000-02-23 2008-02-08 Regulation of fibroblastic growth factor-2 (FGF-2) gene expression in living cells with the application of specific and selective electric and electromagnetic fields
PCT/US2009/032925 WO2009100048A1 (en) 2008-02-08 2009-02-03 Regulation of fibroblastic growth factor-2 (fgf-2) gene expression in living cells with the application of specific and selective electric an electromagnetic fields

Publications (1)

Publication Number Publication Date
CA2712991A1 true CA2712991A1 (en) 2009-08-13

Family

ID=40952436

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2712991A Abandoned CA2712991A1 (en) 2008-02-08 2009-02-03 Up-regulation of fibroblast growth factor 2 (fgf2) gene expression in living cells with the application of specific and selective electric and electromagnetic fields

Country Status (11)

Country Link
US (1) US7981611B2 (https=)
EP (1) EP2250250A4 (https=)
JP (1) JP5596563B2 (https=)
CN (1) CN101939409A (https=)
AU (1) AU2009212561B2 (https=)
CA (1) CA2712991A1 (https=)
IL (1) IL207430A0 (https=)
MX (1) MX2010008765A (https=)
RU (1) RU2010137343A (https=)
WO (1) WO2009100048A1 (https=)
ZA (1) ZA201006311B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8313908B2 (en) * 2000-02-23 2012-11-20 The Trustees Of The University Of Pennsylvania Regulation of stem cell gene production with specific and selective electric and electromagnetic fields
US10188858B2 (en) 2013-09-18 2019-01-29 University Of Cincinnati Method and device for treating a tissue with a high frequency electromagnetic field
WO2017118390A1 (zh) * 2016-01-05 2017-07-13 吴翔 利用变化电场磁场电磁场有选择地操控分子
US10806942B2 (en) 2016-11-10 2020-10-20 Qoravita LLC System and method for applying a low frequency magnetic field to biological tissues
US20240033509A1 (en) * 2022-08-01 2024-02-01 BonGenix, LLC Method and device for stimulating bone growth
CN120983811A (zh) * 2025-10-22 2025-11-21 浙江大学 基于dapk2基因反馈调节的个性化肿瘤电场治疗系统及方法

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US4430999A (en) 1981-11-10 1984-02-14 Trustees Of The University Of Pennsylvania Osteogenesis stimulating cathode assembly for use with an internal fixation device
US4506674A (en) 1981-11-10 1985-03-26 Trustees Of The University Of Pennsylvania Method of stimulating osteogenesis with distributed port cathode
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US4549547A (en) 1982-07-27 1985-10-29 Trustees Of The University Of Pennsylvania Implantable bone growth stimulator
US4467808A (en) 1982-09-17 1984-08-28 Biolectron, Inc. Method for preventing and treating osteoporosis in a living body by using electrical stimulation non-invasively
US4487834A (en) 1982-09-17 1984-12-11 Biolectron, Inc. Electrical stimulation of articular chondrocytes
US4467809A (en) 1982-09-17 1984-08-28 Biolectron, Inc. Method for non-invasive electrical stimulation of epiphyseal plate growth
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IT1159024B (it) 1983-06-02 1987-02-25 Ruggero Cadossi Metodo e dispositivo per il trattamento di tessuti e cellule viventi mediante campi elettromagnetici pulsanti
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RU2147895C1 (ru) 1999-01-05 2000-04-27 Корж Геннадий Михайлович Способ лечения неосложненных переломов нижней челюсти
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Also Published As

Publication number Publication date
JP5596563B2 (ja) 2014-09-24
US7981611B2 (en) 2011-07-19
IL207430A0 (en) 2010-12-30
CN101939409A (zh) 2011-01-05
WO2009100048A1 (en) 2009-08-13
ZA201006311B (en) 2011-07-27
EP2250250A1 (en) 2010-11-17
JP2011514813A (ja) 2011-05-12
AU2009212561B2 (en) 2015-01-29
EP2250250A4 (en) 2011-08-24
AU2009212561A1 (en) 2009-08-13
RU2010137343A (ru) 2012-03-20
MX2010008765A (es) 2010-09-30
US20080215116A1 (en) 2008-09-04

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EEER Examination request

Effective date: 20140203

FZDE Discontinued

Effective date: 20180205