CA2711334A1 - Polypeptides d'hemagglutinine, reactifs, et procedes s'y rapportant - Google Patents

Polypeptides d'hemagglutinine, reactifs, et procedes s'y rapportant Download PDF

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Publication number
CA2711334A1
CA2711334A1 CA2711334A CA2711334A CA2711334A1 CA 2711334 A1 CA2711334 A1 CA 2711334A1 CA 2711334 A CA2711334 A CA 2711334A CA 2711334 A CA2711334 A CA 2711334A CA 2711334 A1 CA2711334 A1 CA 2711334A1
Authority
CA
Canada
Prior art keywords
glycans
umbrella
binding agent
binding
topology
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2711334A
Other languages
English (en)
Inventor
Ram Sasisekharan
Karthik Viswanathan
Aarthi Chandrasekaran
Rahul Raman
Aravind Srinivasan
S. Raguram
Viswanathan Sasisekharan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute Of Technology
Ram Sasisekharan
Karthik Viswanathan
Aarthi Chandrasekaran
Rahul Raman
Aravind Srinivasan
S. Raguram
Viswanathan Sasisekharan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/969,040 external-priority patent/US20090081193A1/en
Application filed by Massachusetts Institute Of Technology, Ram Sasisekharan, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Aravind Srinivasan, S. Raguram, Viswanathan Sasisekharan filed Critical Massachusetts Institute Of Technology
Publication of CA2711334A1 publication Critical patent/CA2711334A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/12—Libraries containing saccharides or polysaccharides, or derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2711334A 2008-01-03 2009-01-02 Polypeptides d'hemagglutinine, reactifs, et procedes s'y rapportant Abandoned CA2711334A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US1878308P 2008-01-03 2008-01-03
US61/018,783 2008-01-03
US11/969,040 US20090081193A1 (en) 2006-08-14 2008-01-03 Hemagglutinin polypeptides, and reagents and methods relating thereto
US11/969,040 2008-01-03
US30112608A 2008-11-17 2008-11-17
US12/301,126 2008-11-17
PCT/US2009/030058 WO2009089121A2 (fr) 2008-01-03 2009-01-02 Polypeptides d'hémagglutinine, réactifs, et procédés s'y rapportant

Publications (1)

Publication Number Publication Date
CA2711334A1 true CA2711334A1 (fr) 2009-07-16

Family

ID=40853716

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2711334A Abandoned CA2711334A1 (fr) 2008-01-03 2009-01-02 Polypeptides d'hemagglutinine, reactifs, et procedes s'y rapportant

Country Status (3)

Country Link
EP (1) EP2238146A4 (fr)
CA (1) CA2711334A1 (fr)
WO (1) WO2009089121A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009051797A1 (fr) 2007-10-16 2009-04-23 Peptimmune, Inc. Procédés de conception et de préparation de vaccins comprenant des compositions de polymères à séquences dirigées via l'expansion dirigée d'épitopes
WO2012040406A2 (fr) 2010-09-21 2012-03-29 Massachusetts Institute Of Technology Traitement et/ou caractérisation de la grippe ; polypeptides ha adaptés à l'homme
RU2663718C2 (ru) * 2010-10-04 2018-08-08 Массачусетс Инститьют Оф Текнолоджи Полипептиды гемагглютининов, а также связанные с ними реагенты и способы
EP3492101A3 (fr) 2012-05-10 2019-10-23 Massachusetts Institute Of Technology Agents de neutralisation de la grippe

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007284496A1 (en) * 2006-08-14 2008-02-21 Massachusetts Institute Of Technology Glycan data mining system

Also Published As

Publication number Publication date
EP2238146A2 (fr) 2010-10-13
WO2009089121A2 (fr) 2009-07-16
WO2009089121A3 (fr) 2009-10-08
EP2238146A4 (fr) 2012-03-21

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20131227

FZDE Dead

Effective date: 20160104