CA2708753A1 - Peptide servant d'agent diagnostique pour deceler la maladie de lyme - Google Patents

Peptide servant d'agent diagnostique pour deceler la maladie de lyme Download PDF

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Publication number
CA2708753A1
CA2708753A1 CA2708753A CA2708753A CA2708753A1 CA 2708753 A1 CA2708753 A1 CA 2708753A1 CA 2708753 A CA2708753 A CA 2708753A CA 2708753 A CA2708753 A CA 2708753A CA 2708753 A1 CA2708753 A1 CA 2708753A1
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Canada
Prior art keywords
peptide
seq
peptides
antibody
sequence
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Granted
Application number
CA2708753A
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English (en)
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CA2708753C (fr
Inventor
Raymond J. Dattwyler
Maria J. Gomes-Solecki
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Biopeptides Corp
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Biopeptides Corp
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Publication date
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Priority to CA2708753A priority Critical patent/CA2708753C/fr
Publication of CA2708753A1 publication Critical patent/CA2708753A1/fr
Application granted granted Critical
Publication of CA2708753C publication Critical patent/CA2708753C/fr
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1207—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/20—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne, par exemple, un peptide isolé qui comprend la série MKKNDQI(V ou G)AAIALRGVA (SEQ ID NO:64), où le peptide n'est pas plus long que 24 acides aminés et où le peptide peut se lier précisément à un anticorps introduit par un agent causal de la maladie de Lyme (une Borrelia pathologique), par exemple dans un échantillon prélevé d'un sujet atteint de la maladie de Lyme. Des versions de ce peptide comprennent, par exemple, la série MKKNDQIVAAIALRGVA (SEQ ID NO:65) ou MKKNDQIGAAIALRGVA (SEQ ID NO:66). Des peptides multimères linéaires sont également décrits et contiennent le peptide représenté par SEQ ID NO:64 ainsi qu'un épitope de peptide supplémentaire, ou plus, issu d'autres protéines de Borrelia qui peuvent également se lier précisément à un anticorps ci-dessus. Les compositions et les trousses de diagnostic qui comprennent un peptide ce cette invention sont décrites, tout comme les analyses diagnostiques qui utilisent le ou les peptides.
CA2708753A 2010-06-25 2010-06-25 Peptide servant d'agent diagnostique pour deceler la maladie de lyme Active CA2708753C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2708753A CA2708753C (fr) 2010-06-25 2010-06-25 Peptide servant d'agent diagnostique pour deceler la maladie de lyme

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2708753A CA2708753C (fr) 2010-06-25 2010-06-25 Peptide servant d'agent diagnostique pour deceler la maladie de lyme

Publications (2)

Publication Number Publication Date
CA2708753A1 true CA2708753A1 (fr) 2011-12-25
CA2708753C CA2708753C (fr) 2014-02-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2708753A Active CA2708753C (fr) 2010-06-25 2010-06-25 Peptide servant d'agent diagnostique pour deceler la maladie de lyme

Country Status (1)

Country Link
CA (1) CA2708753C (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2809348A4 (fr) * 2012-02-01 2016-01-06 Biopeptides Corp Peptides diagnostiques pour la maladie de lyme
WO2017062535A2 (fr) 2015-10-06 2017-04-13 Bio-Rad Laboratories, Inc. Dosages immunologiques de borrelia et matériaux associés
US10006912B2 (en) * 2013-12-06 2018-06-26 Biopeptides Llc Peptides for diagnosing lyme disease
CN111727374A (zh) * 2017-10-13 2020-09-29 纳米智能生物医学工程有限公司 Grp78衍生肽用于鉴定高效干细胞

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2809348A4 (fr) * 2012-02-01 2016-01-06 Biopeptides Corp Peptides diagnostiques pour la maladie de lyme
US9816991B2 (en) 2012-02-01 2017-11-14 Biopeptides Corporation Diagnostic peptides for lyme disease
EP3447064A1 (fr) * 2012-02-01 2019-02-27 Biopeptides Corporation Peptides de diagnostic pour la maladie de lyme
US10006912B2 (en) * 2013-12-06 2018-06-26 Biopeptides Llc Peptides for diagnosing lyme disease
WO2017062535A2 (fr) 2015-10-06 2017-04-13 Bio-Rad Laboratories, Inc. Dosages immunologiques de borrelia et matériaux associés
EP3359558A4 (fr) * 2015-10-06 2019-08-14 Bio-rad Laboratories, Inc. Dosages immunologiques de borrelia et matériaux associés
US11209431B2 (en) 2015-10-06 2021-12-28 Bio-Rad Laboratories, Inc. Borrelia immunoassays and materials therefor
CN111727374A (zh) * 2017-10-13 2020-09-29 纳米智能生物医学工程有限公司 Grp78衍生肽用于鉴定高效干细胞
CN111727374B (zh) * 2017-10-13 2024-02-20 纳米智能生物医学工程有限公司 Grp78衍生肽用于鉴定高效干细胞

Also Published As

Publication number Publication date
CA2708753C (fr) 2014-02-18

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