CA2687403A1 - Carbohydrate-containing pan cancer marker - Google Patents
Carbohydrate-containing pan cancer marker Download PDFInfo
- Publication number
- CA2687403A1 CA2687403A1 CA002687403A CA2687403A CA2687403A1 CA 2687403 A1 CA2687403 A1 CA 2687403A1 CA 002687403 A CA002687403 A CA 002687403A CA 2687403 A CA2687403 A CA 2687403A CA 2687403 A1 CA2687403 A1 CA 2687403A1
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- igg
- human
- composition
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/02—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates involving antibodies to sugar part of glycoproteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91790607P | 2007-05-14 | 2007-05-14 | |
| US60/917,906 | 2007-05-14 | ||
| US4402808P | 2008-04-10 | 2008-04-10 | |
| US61/044,028 | 2008-04-10 | ||
| PCT/CA2008/000932 WO2008138139A1 (en) | 2007-05-14 | 2008-05-14 | Carbohydrate-containing pan cancer marker |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2687403A1 true CA2687403A1 (en) | 2008-11-20 |
Family
ID=40001646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002687403A Abandoned CA2687403A1 (en) | 2007-05-14 | 2008-05-14 | Carbohydrate-containing pan cancer marker |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8143373B2 (enExample) |
| EP (1) | EP2155250B1 (enExample) |
| JP (1) | JP5683948B2 (enExample) |
| CN (1) | CN102014955A (enExample) |
| AU (1) | AU2008250953B2 (enExample) |
| CA (1) | CA2687403A1 (enExample) |
| WO (1) | WO2008138139A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2841866A1 (en) * | 2010-07-14 | 2012-01-19 | Vancouver Biotech Ltd. | Carbohydrate hapten-based anti-cancer vaccines and antibody drugs |
| CN102901817A (zh) * | 2011-07-27 | 2013-01-30 | 北京大学 | Non-B Ig单抗RP215在细胞增殖、迁移及干细胞研究中的应用 |
| US8974786B2 (en) * | 2012-06-13 | 2015-03-10 | Vancouver Biotech Ltd. | Humanized antibodies to CA215 |
| CN105353132B (zh) * | 2015-11-13 | 2018-04-10 | 北京大学 | non B‑s IgG作为干/祖细胞标志物的应用 |
| CA3048312A1 (en) | 2017-01-01 | 2018-07-05 | Chi-Yu Gregory Lee | Rp215 chimeric antigen receptor construct and methods of making and using same |
| CN108484777B (zh) * | 2017-03-31 | 2022-07-12 | 李吉祐 | 人源化rp215单克隆抗体的嵌合抗原受体构建体及核酸分子与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| AU6031090A (en) * | 1989-07-31 | 1991-03-11 | University Of British Columbia, The | Monoclonal antibodies against a tumor-associated antigen |
| US6312924B1 (en) * | 1999-03-18 | 2001-11-06 | Zymogenetics, Inc. | Murine interferon-α |
| US6908612B2 (en) * | 1999-10-08 | 2005-06-21 | University Of Maryland Biotechnology Institute | Virus coat protein/receptor chimeras and methods of use |
| KR20040101428A (ko) * | 2002-04-09 | 2004-12-02 | 메르크 파텐트 게엠베하 | 항유전인자형 항-cea 항체 분자 및 암백신으로서의이의 용도 |
| WO2005037261A1 (en) * | 2003-10-14 | 2005-04-28 | Biomira, Inc. | Combination therapy for cancer |
-
2008
- 2008-05-14 EP EP08757092.5A patent/EP2155250B1/en active Active
- 2008-05-14 CA CA002687403A patent/CA2687403A1/en not_active Abandoned
- 2008-05-14 AU AU2008250953A patent/AU2008250953B2/en not_active Ceased
- 2008-05-14 CN CN200880001243XA patent/CN102014955A/zh active Pending
- 2008-05-14 WO PCT/CA2008/000932 patent/WO2008138139A1/en not_active Ceased
- 2008-05-14 US US12/599,284 patent/US8143373B2/en active Active - Reinstated
- 2008-05-14 JP JP2010507772A patent/JP5683948B2/ja active Active
-
2012
- 2012-03-22 US US13/427,109 patent/US20120177636A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2155250B1 (en) | 2015-04-15 |
| AU2008250953B2 (en) | 2013-10-31 |
| AU2008250953A2 (en) | 2011-02-10 |
| EP2155250A1 (en) | 2010-02-24 |
| US8143373B2 (en) | 2012-03-27 |
| CN102014955A (zh) | 2011-04-13 |
| JP5683948B2 (ja) | 2015-03-11 |
| US20110033445A1 (en) | 2011-02-10 |
| US20120177636A1 (en) | 2012-07-12 |
| WO2008138139A1 (en) | 2008-11-20 |
| JP2010529950A (ja) | 2010-09-02 |
| EP2155250A4 (en) | 2011-04-13 |
| AU2008250953A1 (en) | 2008-11-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12453780B2 (en) | Monoclonal antibodies specific for fibroblast growth factor receptor 4 (FGFR4) and methods of their use | |
| US12180296B2 (en) | Cross species single domain antibodies targeting mesothelin for treating solid tumors | |
| US10941211B2 (en) | Anti-GCC antibody molecules and related compositions and methods | |
| AU2011200789B2 (en) | Cytotoxicity mediation of cells evidencing surface expression of CD44 | |
| RU2670748C9 (ru) | Конъюгаты антител с лекарственными агентами, обладающие улучшенной стабильностью, и их применение | |
| US12122843B2 (en) | High affinity monoclonal antibodies targeting glypican-1 and methods of use | |
| US9738726B2 (en) | HER2-specific monoclonal antibodies and conjugates thereof | |
| EA027887B1 (ru) | Конъюгаты антитело-лекарственное средство, связывающиеся с белками 191p4d12 | |
| CN104059150A (zh) | 结合epha2的抗体及其使用方法 | |
| AU2018268970B2 (en) | Human monoclonal antibody targeting tnfr2 for cancer immunotherapy | |
| AU2008250953B2 (en) | Carbohydrate-containing pan cancer marker | |
| CN1901936B (zh) | 证明cd44表面表达的细胞的细胞毒性介导 | |
| CN114650843A (zh) | 包括fc突变和位点特异性缀合性质的抗体组合物 | |
| US20230032465A1 (en) | Antibody-drug conjugates specific for cd276 and uses thereof | |
| TWI904701B (zh) | 抗ceacam5/6雙結合抗體 | |
| CA2996205C (en) | Monoclonal antibodies specific for fibroblast growth factor receptor 4 (fgfr4) and methods of their use | |
| CN119403830A (zh) | 抗cd200r1抗体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130509 |
|
| FZDE | Discontinued |
Effective date: 20170201 |