CA2676156C - Method and apparatus for producing a centred compression coated tablet - Google Patents
Method and apparatus for producing a centred compression coated tablet Download PDFInfo
- Publication number
- CA2676156C CA2676156C CA2676156A CA2676156A CA2676156C CA 2676156 C CA2676156 C CA 2676156C CA 2676156 A CA2676156 A CA 2676156A CA 2676156 A CA2676156 A CA 2676156A CA 2676156 C CA2676156 C CA 2676156C
- Authority
- CA
- Canada
- Prior art keywords
- pin
- housing
- punch
- applying pressure
- powdered material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/34—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses for coating articles, e.g. tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/22—Extrusion presses; Dies therefor
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a method and apparatus for positioning the core of the compression coated tablet in manufacturing techniques for the production of such tablets.
Description
Method and apparatus for producing a centred compression coated tablet The invention relates to the manufacturing of compression coated tablets. In particular, the invention relates to a method and apparatus for improving the centring of the core of a compression coated tablet.
Pharmaceutical tablets are a convenient, easy and relatively cheap way of administering an accurate pharmaceutical dose in oral form.
Conventional tablets are designed to deliver their content immediately after being swallowed. However for many drugs, a different drug release profile is required for therapeutical efficacy or better patient compliance. Conventional tablets may not be able to solve problems with drug incompatibility.
Various technologies have been developed to answer to these problems, for example film coated tablets, multilayer tablets or compression coated tablets.
Compression coated tablets are manufactured by compression of a tablet within a tablet so that the outer coat becomes a coating. As many as two different coats can be compressed around a core tablet. Compression coated tablets may also be known as "press coated" tablets or "dry coated" tablets. As multilayer tablets, compression coated tablets can be used to separate incompatible drugs. They can also be used for modified release formulation.
The development of tablet presses to manufacture compression coated tablets is almost as old as the development of tablet presses for conventional tablets.
An early patent relating to the manufacture of compression coated tablets is US patent 568,488 which granted in 1886. The essential features of this invention are a mould box or a cavity for receiving the charges of coating material and the pill or tablet with
Pharmaceutical tablets are a convenient, easy and relatively cheap way of administering an accurate pharmaceutical dose in oral form.
Conventional tablets are designed to deliver their content immediately after being swallowed. However for many drugs, a different drug release profile is required for therapeutical efficacy or better patient compliance. Conventional tablets may not be able to solve problems with drug incompatibility.
Various technologies have been developed to answer to these problems, for example film coated tablets, multilayer tablets or compression coated tablets.
Compression coated tablets are manufactured by compression of a tablet within a tablet so that the outer coat becomes a coating. As many as two different coats can be compressed around a core tablet. Compression coated tablets may also be known as "press coated" tablets or "dry coated" tablets. As multilayer tablets, compression coated tablets can be used to separate incompatible drugs. They can also be used for modified release formulation.
The development of tablet presses to manufacture compression coated tablets is almost as old as the development of tablet presses for conventional tablets.
An early patent relating to the manufacture of compression coated tablets is US patent 568,488 which granted in 1886. The essential features of this invention are a mould box or a cavity for receiving the charges of coating material and the pill or tablet with
2 a mould member or die forming its bottom. The supply of coating material and feeding of pills to the mould cavity is automatically regulated. The coating material is fed by a hopper and the pill is fed via an included chute and a check finger which moves intermittently to permit the escape of the pills singly. The machine described in this patent could make only the press coating of pre-formed cores (pills/tablets). An improvement of this technology could be found in US patent 582,794 that describes a machine combining a mechanism for forming the tablet prior to automatically applying a coating. The whole process can be accomplished in one operation.
The machine is equipped with a transferring mechanism which rotates at the same speed to a forming and a coating disk and is located at a point intermediate of their axis. The overlapping of the transferring mechanism with the forming and the coating disk allow the upward transfer of the compressed tablet into the chamber of the transfer device and then their ejection downwards into the coating moulds.
The next advance occurred in 1917 with US patent 1,248,571 that described a machine having a core feeding system based on a toothed disk. Cores are prepared separately and transferred by the feeding disk into the dices. Synchronisation of the feeding disk is controlled by a starwheel which is actuated in turn by projections on the turret.
In a process for the rapid coating of tablets by compression, US patents 2,700,938 and 2,727,473 (Wolf) identified two major problems to be solved; the first one being the exact centring of the core within the die in which it is to be coated and secondly the immediate removal of the core from whatever transfer means is used to carry it to the die without disturbing the positioning of the core within the die. Accurate positioning of the core in the final press coated tablets could be a critical parameter for efficacy of the drug delivery system. Wolf's patents report a rapid withdraw of the bottom punch after core deposition in order to avoid any further contact of the feeding disk with the core and therefore off centring of the core. A further improvement for the deposition of the core is a feed support plate element which is a thin arcuate shaped like member
The machine is equipped with a transferring mechanism which rotates at the same speed to a forming and a coating disk and is located at a point intermediate of their axis. The overlapping of the transferring mechanism with the forming and the coating disk allow the upward transfer of the compressed tablet into the chamber of the transfer device and then their ejection downwards into the coating moulds.
The next advance occurred in 1917 with US patent 1,248,571 that described a machine having a core feeding system based on a toothed disk. Cores are prepared separately and transferred by the feeding disk into the dices. Synchronisation of the feeding disk is controlled by a starwheel which is actuated in turn by projections on the turret.
In a process for the rapid coating of tablets by compression, US patents 2,700,938 and 2,727,473 (Wolf) identified two major problems to be solved; the first one being the exact centring of the core within the die in which it is to be coated and secondly the immediate removal of the core from whatever transfer means is used to carry it to the die without disturbing the positioning of the core within the die. Accurate positioning of the core in the final press coated tablets could be a critical parameter for efficacy of the drug delivery system. Wolf's patents report a rapid withdraw of the bottom punch after core deposition in order to avoid any further contact of the feeding disk with the core and therefore off centring of the core. A further improvement for the deposition of the core is a feed support plate element which is a thin arcuate shaped like member
3 PCT/IB2008/000648 which allows the core to slide or drop slightly from the support plate element onto the bottom fill.
US patent 2,849,965 (Stott) describes a machine for manufacturing press coated tablets in which the transfer and the deposition of the core is done with a telescopic or contractile transfer arm. The transfer mechanism has a cavity in which the core tablet can fit closely to enable the core to be transferred to its correct position on the bottom fill. The system is also equipped with a slidable weight which is used to release the tablet and to apply a slight pressure to the core to prevent it from being lifted out of its settled position.
US 3,000,331 addressed the problem occurring in prior art machines whereby the cores are delivered to the dies by feeding systems disposed about the periphery of a wheel that partially overlaps the upper surface of the turntable. There is only one possible point of perfect alignment of the cores with the dies therefore an accurate coordination of the rotation of the feeding disk and the turntable is mandatory. US
3,000,331 describes a system where the core is delivered to each die by moving the tablet along an arc portion of the path of the dices in vertical alignment with the die cavity and pushing down the core while it is being deposited. The deposition along the arc allows a smooth transfer and accurate positioning of the core for the feeding system into the tablet die.
In the last few years, a lot of work has been done by Korsch Company in the field of compression coating. US patent 5,088,915, describes a core transfer system equipped with sliding arms having one transfer head, each of which are guided by a grooved cam. The grooved cam of the feeding disk has a specific curved shape which allows accurate overlapping of the transfer head and dies over an arc portion of the path of the dices. This approach allows for better core positioning because the perfect alignment of the transfer head/die is not limited to a single point. The upper punch of the
US patent 2,849,965 (Stott) describes a machine for manufacturing press coated tablets in which the transfer and the deposition of the core is done with a telescopic or contractile transfer arm. The transfer mechanism has a cavity in which the core tablet can fit closely to enable the core to be transferred to its correct position on the bottom fill. The system is also equipped with a slidable weight which is used to release the tablet and to apply a slight pressure to the core to prevent it from being lifted out of its settled position.
US 3,000,331 addressed the problem occurring in prior art machines whereby the cores are delivered to the dies by feeding systems disposed about the periphery of a wheel that partially overlaps the upper surface of the turntable. There is only one possible point of perfect alignment of the cores with the dies therefore an accurate coordination of the rotation of the feeding disk and the turntable is mandatory. US
3,000,331 describes a system where the core is delivered to each die by moving the tablet along an arc portion of the path of the dices in vertical alignment with the die cavity and pushing down the core while it is being deposited. The deposition along the arc allows a smooth transfer and accurate positioning of the core for the feeding system into the tablet die.
In the last few years, a lot of work has been done by Korsch Company in the field of compression coating. US patent 5,088,915, describes a core transfer system equipped with sliding arms having one transfer head, each of which are guided by a grooved cam. The grooved cam of the feeding disk has a specific curved shape which allows accurate overlapping of the transfer head and dies over an arc portion of the path of the dices. This approach allows for better core positioning because the perfect alignment of the transfer head/die is not limited to a single point. The upper punch of the
4 invention can be used to push down the core out of the transfer head and press it slightly in the bottom fill in order to secure the positioning of this latter.
A further improvement is described in US 5,256,046. The radial arms are inwardly and outwardly movably supported in the turntable rotor and the core receiving pockets are arranged on a partial circle of the die table. Therefore, a simple movement of the radial arms over the die table transfers the cores from the receiving pockets into the dies and a separate transfer device is not required. The design of such a machine guarantees mechanically a perfect alignment of the transfer head with the dies over a long arc portion of the path of the dices. Other features previously described, like using the upper punch for pushing down the core onto the bottom fill and pressing it slightly to secure its position are also implemented on this tablet press.
US patent 4,569,650 reports a machine having an inbuilt suction device for ram punches used for the manufacturing of annular tablets, to remove dust from the apparatus. Punches used for manufacturing of annular tablets consist of a stationary ram and a movable ram which move up during filling of the die with powder and remains in place during the compression step in order to give to the tablet a ring shape (or donut shape). The granular powder can get in between the surfaces moving relatively to one another on the stationary ram and movable ram. This could lead rapidly to blocking of the system unless they are cleaned in due time. The suction device described in this invention aims to prevent accumulation of powder in the hollow of the ram punches and allow continuous production of donut shaped tablets.
M. Hariharan & V.K. Gupta "A novel concept for the production of compression-coated tablets" Pharmaceutical Technology Europe April 2002 page 46-56 describes a punch system for forming a compression coated tablet which does not require separate formation of a core tablet or a transfer mechanism for transferring the cores into a layer of coating material. This document describes forming the core of the tablet by adding the core blend to in its granular form to the coating material and then compressing the material to form a tablet.
There is a need for an improved tooling capable of increasing the accuracy of the
A further improvement is described in US 5,256,046. The radial arms are inwardly and outwardly movably supported in the turntable rotor and the core receiving pockets are arranged on a partial circle of the die table. Therefore, a simple movement of the radial arms over the die table transfers the cores from the receiving pockets into the dies and a separate transfer device is not required. The design of such a machine guarantees mechanically a perfect alignment of the transfer head with the dies over a long arc portion of the path of the dices. Other features previously described, like using the upper punch for pushing down the core onto the bottom fill and pressing it slightly to secure its position are also implemented on this tablet press.
US patent 4,569,650 reports a machine having an inbuilt suction device for ram punches used for the manufacturing of annular tablets, to remove dust from the apparatus. Punches used for manufacturing of annular tablets consist of a stationary ram and a movable ram which move up during filling of the die with powder and remains in place during the compression step in order to give to the tablet a ring shape (or donut shape). The granular powder can get in between the surfaces moving relatively to one another on the stationary ram and movable ram. This could lead rapidly to blocking of the system unless they are cleaned in due time. The suction device described in this invention aims to prevent accumulation of powder in the hollow of the ram punches and allow continuous production of donut shaped tablets.
M. Hariharan & V.K. Gupta "A novel concept for the production of compression-coated tablets" Pharmaceutical Technology Europe April 2002 page 46-56 describes a punch system for forming a compression coated tablet which does not require separate formation of a core tablet or a transfer mechanism for transferring the cores into a layer of coating material. This document describes forming the core of the tablet by adding the core blend to in its granular form to the coating material and then compressing the material to form a tablet.
There is a need for an improved tooling capable of increasing the accuracy of the
5 positioning of the core of compression coated tablets. There is also a need for a means to avoid movement of the core due to the operation of centrifugal forces on high speed tablet machines from its central position after it has been deposited.
The present invention provides an improvement of the centring of the core in compression coated tablets. The invention is a tooling, which can be used with limited modifications of the machine on any tablet press designed for compression coating.
The invention aims to maintain the core in a centred position after its deposition on the bottom fill and limit therefore the effect of the centrifugal force that can be noticed on high speed presses. The efficacy of the invention for core centring is independent of the core feeding system used.
According to a first aspect of the invention there is provided a method of producing a compression coated tablet, the method comprising the steps of:
(a) filling a die with a first powdered material;
(b) contacting the powdered material in the die with a shaped punch assembly and applying pressure to the punch to create an imprint in the powdered material, in which the punch comprises a housing adapted to receive a pin which is movable within the housing, the pin having a protruding element at one end for engagement with a means for applying pressure to the pin and punch housing, the pin being provided with a torsion means for engagement with the housing, in which the punch has a brake means for retarding movement of the pin in the housing; wherein the pin is held in a first position by the brake means to engage the protruding element of the pin with the means for applying pressure, to cause movement of the pin within the housing into the powdered material to create the imprint in the powdered material
The present invention provides an improvement of the centring of the core in compression coated tablets. The invention is a tooling, which can be used with limited modifications of the machine on any tablet press designed for compression coating.
The invention aims to maintain the core in a centred position after its deposition on the bottom fill and limit therefore the effect of the centrifugal force that can be noticed on high speed presses. The efficacy of the invention for core centring is independent of the core feeding system used.
According to a first aspect of the invention there is provided a method of producing a compression coated tablet, the method comprising the steps of:
(a) filling a die with a first powdered material;
(b) contacting the powdered material in the die with a shaped punch assembly and applying pressure to the punch to create an imprint in the powdered material, in which the punch comprises a housing adapted to receive a pin which is movable within the housing, the pin having a protruding element at one end for engagement with a means for applying pressure to the pin and punch housing, the pin being provided with a torsion means for engagement with the housing, in which the punch has a brake means for retarding movement of the pin in the housing; wherein the pin is held in a first position by the brake means to engage the protruding element of the pin with the means for applying pressure, to cause movement of the pin within the housing into the powdered material to create the imprint in the powdered material
6 (c) depositing a tablet core in the imprint created in the powdered material to form a partly coated compression coated tablet; and optionally (d) introducing a second powdered material into the die on to the upper surface of the partly coated compression coated tablet; and (e) contacting the second powdered material with the punch and applying pressure to the punch to form a fully coated compression coated tablet, wherein the pin is held in the second position in the housing by the brake means and the means for applying pressure is adapted so as to engage with the housing of the punch only and not to engage with the pin.
Compression coated tablets comprise a core containing an active agent in association with one or more support and/or barrier layers. Such tablets may form multi-layer tablets in which the core is surrounded by two or more layers. The arrangement and orientation of layers can be selected as necessary.
The compression coated tablets may have an overall substantially circular cross-section, or may adopt a more oval cross-section or any other suitable geometric shape, for example rectilinear. The tablet may also be shaped as a caplet (capsule form tablet).
In some tablet configurations, the barrier layer may also contain an active substance such that it acts as a barrier layer with respect to a first active substance containing layer, but which itself is an active substance containing layer. Generally, in such embodiments, the active substance in the active layers is different in the separate layers, although arrangements in which the same active substance is present in the separate active layers in different amounts can also be envisaged.
Any pharmaceutically active substance suitable for oral administration in the form of a tablet can be formulated in a tablet of the present invention. An active substance is therefore a pharmaceutical (drug) with a therapeutic use. Such substances also include
Compression coated tablets comprise a core containing an active agent in association with one or more support and/or barrier layers. Such tablets may form multi-layer tablets in which the core is surrounded by two or more layers. The arrangement and orientation of layers can be selected as necessary.
The compression coated tablets may have an overall substantially circular cross-section, or may adopt a more oval cross-section or any other suitable geometric shape, for example rectilinear. The tablet may also be shaped as a caplet (capsule form tablet).
In some tablet configurations, the barrier layer may also contain an active substance such that it acts as a barrier layer with respect to a first active substance containing layer, but which itself is an active substance containing layer. Generally, in such embodiments, the active substance in the active layers is different in the separate layers, although arrangements in which the same active substance is present in the separate active layers in different amounts can also be envisaged.
Any pharmaceutically active substance suitable for oral administration in the form of a tablet can be formulated in a tablet of the present invention. An active substance is therefore a pharmaceutical (drug) with a therapeutic use. Such substances also include
7 those for administration for non-therapeutic uses, such as diagnosis or for dietary purposes.
Preferably the active substance may be one aimed at the treatment of chronic diseases, for example, drugs acting on the cardiovascular system, anti-arrhythmics, cardiac stimulants, vasodilators, calcium antagonists, anti-hypertensives, for example anti-adrenergic substances of central and peripheral action or substances acting on the arteriolar musculature, analgesic substances, substances acting on the renin-angiotensin system, anti-hypertensives and diuretics in association, anti-Parkinson's Disease agents, diuretics and drugs for the treatment of Alzheimer's disease, anti-histamines and/or anti-asthmatics.
Powders can be produced by any of the known techniques such as milling, micronisation, granulation or comminution. The first powdered material may be a granular composition of an active agent and one or more pharmaceutically acceptable excipients and/or diluents. Suitable excipients and diluents are well known in the art and include materials for controlled release (sustained and/or delayed release) and immediate release of active agent from the tablet.
Where the powdered material is prepared for formulation of a controlled release granulate, the material may comprise one or more natural or synthetic hydrophilic polymeric substances, which are biocompatible and/or biodegradable materials and pharmaceutically acceptable, e.g. polyvinylpyrrolidone in particular non-cross-linked polyvinylpyrrolidone (e.g. of molecular weight 30,000-400,000), hydroxypropylcellulose with a molecular weight of from 100,000 to 4,000,000, sodium carboxymethylcellulose (e.g. non-cross-linked, e.g. typical molecular weight 90,000-700,000), carboxymethylstarch, potassium methacrylate-divinylbenzene copolymer, hydroxypropylmethylcellulose with a molecular weight of between 2,000 and 4,000,000, polyethyleneglycols of different molecular weight preferably between 200 and 15,000 (more preferably 1000-15000) and polyoxyethylenes of molecular
Preferably the active substance may be one aimed at the treatment of chronic diseases, for example, drugs acting on the cardiovascular system, anti-arrhythmics, cardiac stimulants, vasodilators, calcium antagonists, anti-hypertensives, for example anti-adrenergic substances of central and peripheral action or substances acting on the arteriolar musculature, analgesic substances, substances acting on the renin-angiotensin system, anti-hypertensives and diuretics in association, anti-Parkinson's Disease agents, diuretics and drugs for the treatment of Alzheimer's disease, anti-histamines and/or anti-asthmatics.
Powders can be produced by any of the known techniques such as milling, micronisation, granulation or comminution. The first powdered material may be a granular composition of an active agent and one or more pharmaceutically acceptable excipients and/or diluents. Suitable excipients and diluents are well known in the art and include materials for controlled release (sustained and/or delayed release) and immediate release of active agent from the tablet.
Where the powdered material is prepared for formulation of a controlled release granulate, the material may comprise one or more natural or synthetic hydrophilic polymeric substances, which are biocompatible and/or biodegradable materials and pharmaceutically acceptable, e.g. polyvinylpyrrolidone in particular non-cross-linked polyvinylpyrrolidone (e.g. of molecular weight 30,000-400,000), hydroxypropylcellulose with a molecular weight of from 100,000 to 4,000,000, sodium carboxymethylcellulose (e.g. non-cross-linked, e.g. typical molecular weight 90,000-700,000), carboxymethylstarch, potassium methacrylate-divinylbenzene copolymer, hydroxypropylmethylcellulose with a molecular weight of between 2,000 and 4,000,000, polyethyleneglycols of different molecular weight preferably between 200 and 15,000 (more preferably 1000-15000) and polyoxyethylenes of molecular
8 weight up to 20,000,000 (more preferably 400,000-7,000,000), carboxyvinylpolymers, poloxamers (polyoxyethylene-polyoxypropylene copolymer), polyvinylalcohols, glucanes (glucans), carrageenans, scleroglucanes (scleroglucans), mannans, galactomannans, gellans, xanthans, alginic acid and derivatives (e.g. sodium or calcium alginate, propylene glycol alginate), polyaminoacids (e.g. gelatin), methyl vinyl ether / maleic anhydride copolymer, carboxymethylcellulose and derivatives (e.g. calcium carboxymethylcellulose), ethylcellulose, methylcellulose, starch and starch derivatives, alpha, beta or gamma cyclodextrin, and dextrin derivatives (e.g.
dextrin) in general. The hydrophilic polymeric substance is therefore one which can be described as a controlled release polymer or a polymeric substance whiCh is capable of achieving controlled release (CR).
A die according to the invention suitably comprises a cavity in which a tablet can be formed. The die may be filled with a layer of the first powdered material in which an imprint is then created by the action of the shaped punch assembly. Following creation of the imprint, the die is further filled with the second powdered material which is compressed to form the final tablet.
The second powdered material can be identical or different to the first powdered material. Optionally, such a further layer of powdered material may be added to the contents of the die, followed by further compression steps to create a multi-layer tablet.
The powder can suitably be contacted by the shaped punch assembly by lowering the punch assembly until it touches the surface of the powder in the die.
Suitably, the shaped punch assembly is round in cross section. However, the cross section of the punch may be any suitable shape. The housing of the punch assembly may be cylindrical, although the housing may be any other suitable shape to correspond to the shape of the pin.
dextrin) in general. The hydrophilic polymeric substance is therefore one which can be described as a controlled release polymer or a polymeric substance whiCh is capable of achieving controlled release (CR).
A die according to the invention suitably comprises a cavity in which a tablet can be formed. The die may be filled with a layer of the first powdered material in which an imprint is then created by the action of the shaped punch assembly. Following creation of the imprint, the die is further filled with the second powdered material which is compressed to form the final tablet.
The second powdered material can be identical or different to the first powdered material. Optionally, such a further layer of powdered material may be added to the contents of the die, followed by further compression steps to create a multi-layer tablet.
The powder can suitably be contacted by the shaped punch assembly by lowering the punch assembly until it touches the surface of the powder in the die.
Suitably, the shaped punch assembly is round in cross section. However, the cross section of the punch may be any suitable shape. The housing of the punch assembly may be cylindrical, although the housing may be any other suitable shape to correspond to the shape of the pin.
9 According to this aspect of the invention, when the pin is in the first position, the protruding element of the pin extends beyond one end of the housing and the opposite end of the pin is flush with the housing. When the pin is in the second position, the protruding element of the pin is flush with one end of the housing and the opposite end of the pin protrudes from the housing.
The means for applying pressure to the punch may comprise a roll. The roll can contact the protruding element of the pin in action and can apply pressure to cause movement of the pin within the housing and into the powdered material to create an imprint in the powdered material. The distance moved by the pin is defined by the height of the protruding element of the pin. Pressure can be applied on the protruding element of the pin by the roll until the roll contacts the housing when the protruding element of the pin has been depressed until it is level with the top of the housing.
The protruding element of the pin may comprise a raised portion located on the top surface of the pin. The height of the raised portion is equal to the depth of the powder imprint required. The raised portion may occupy a section of the top surface of the pin, or cover the full surface of the top of the pin.
The depth of the imprint created by movement of the pin into the powdered material is suitably equal to the depth of the tablet core of the compression coated tablet to be deposited in the imprint. The depth of the imprint formed within the bottom fill suitably is less than 1.5 mm and the height of the raised portion located at the top of the inside cylinder is therefore suitably less than 1.5 mm.
The imprint forms a "cup" within the powdered material suitable for receiving a pre-formed core. The sides of the "cup" may act as a guide to ensure that the core does not move after its deposition in the bottom fill.
The torsion means may comprise a spring. However, any suitable torsion means may be used in the invention.
5 Preferably the brake means may comprise a key, which protrudes horizontally from the pin and communicates with a recess in the housing of the punch assembly to act as a stop to define the extent of movement of the pin relative to the housing.
The means for applying pressure may be adapted to engage only the housing of the
The means for applying pressure to the punch may comprise a roll. The roll can contact the protruding element of the pin in action and can apply pressure to cause movement of the pin within the housing and into the powdered material to create an imprint in the powdered material. The distance moved by the pin is defined by the height of the protruding element of the pin. Pressure can be applied on the protruding element of the pin by the roll until the roll contacts the housing when the protruding element of the pin has been depressed until it is level with the top of the housing.
The protruding element of the pin may comprise a raised portion located on the top surface of the pin. The height of the raised portion is equal to the depth of the powder imprint required. The raised portion may occupy a section of the top surface of the pin, or cover the full surface of the top of the pin.
The depth of the imprint created by movement of the pin into the powdered material is suitably equal to the depth of the tablet core of the compression coated tablet to be deposited in the imprint. The depth of the imprint formed within the bottom fill suitably is less than 1.5 mm and the height of the raised portion located at the top of the inside cylinder is therefore suitably less than 1.5 mm.
The imprint forms a "cup" within the powdered material suitable for receiving a pre-formed core. The sides of the "cup" may act as a guide to ensure that the core does not move after its deposition in the bottom fill.
The torsion means may comprise a spring. However, any suitable torsion means may be used in the invention.
5 Preferably the brake means may comprise a key, which protrudes horizontally from the pin and communicates with a recess in the housing of the punch assembly to act as a stop to define the extent of movement of the pin relative to the housing.
The means for applying pressure may be adapted to engage only the housing of the
10 punch by having a groove which fits over the protruding element of the pin.
The means for applying pressure may be a roll, or any other suitable means for applying pressure conventionally used in tableting presses. The groove can be equal to or wider than the width of the protruding element of the pin. The roll therefore does not apply any pressure to the pin via the protruding element, but only contacts the housing.
The pin therefore remains in the second position, with the end of the pin flush with the end of the housing.
It is desirable that the pin punch cylinder may be easily dismantled for cleaning purposes.
According to a second aspect of the invention there is provided an apparatus for producing a compression coated tablet comprising, a punch assembly which comprises a housing and a pin which is movable within the housing, in which the housing is adapted to receive and engage with the pin, the pin having a protruding element at one end, adapted for engagement with a first means for applying pressure to the pin to move the pin relative to the housing from a first position to a second position, the pin being provided with a torsion means to return the pin to the first position upon removal of the means for applying pressure, and in which the punch has a brake means for retarding movement of the pin in the housing beyond the first position.
The means for applying pressure may be a roll, or any other suitable means for applying pressure conventionally used in tableting presses. The groove can be equal to or wider than the width of the protruding element of the pin. The roll therefore does not apply any pressure to the pin via the protruding element, but only contacts the housing.
The pin therefore remains in the second position, with the end of the pin flush with the end of the housing.
It is desirable that the pin punch cylinder may be easily dismantled for cleaning purposes.
According to a second aspect of the invention there is provided an apparatus for producing a compression coated tablet comprising, a punch assembly which comprises a housing and a pin which is movable within the housing, in which the housing is adapted to receive and engage with the pin, the pin having a protruding element at one end, adapted for engagement with a first means for applying pressure to the pin to move the pin relative to the housing from a first position to a second position, the pin being provided with a torsion means to return the pin to the first position upon removal of the means for applying pressure, and in which the punch has a brake means for retarding movement of the pin in the housing beyond the first position.
11 The apparatus may further comprise a means for applying pressure to the housing only. The means for applying pressure to the housing only may comprise a roll adapted by having a groove in its surface. The groove should preferably be deeper than the height of the protruding element of the pin. The width of the groove should be equal to or wider than the width of the protruding element of the pin and should take into account the curvature of the turntable in order to avoid any contact of the raised portion with the side of the groove. The groove can be positioned on the roll to fit over the protruding element of the pin and therefore does not apply any pressure to the pin, but only contacts the housing. The pin therefore remains in the second position.
The use of the invention on a dry coating tablet press therefore requires as its sole adjustment the modification of the roll that applies the final pressure to form the press coated tablets. If the press is equipped with a roll for pre-compression then this roll should also be modified.
Preferred features for the second aspect of the invention are as for the first mutatis mutandis.
The invention will now be further described by way of reference to an Example and a description of a preferred embodiment of the invention in use which is present for the purposes of illustration only and is not to be construed as being limiting on the invention. In the Example and the description of the preferred embodiment, reference is made to a number of drawings in which:
Figure 1- Shows a cross sectional view of the two parts of the pinch punch assembly Figure 2- shows a cross sectional view of the pin punch assembly in its rest position Figure 3 -shows a cross sectional view of the pin punch assembly in its punching position
The use of the invention on a dry coating tablet press therefore requires as its sole adjustment the modification of the roll that applies the final pressure to form the press coated tablets. If the press is equipped with a roll for pre-compression then this roll should also be modified.
Preferred features for the second aspect of the invention are as for the first mutatis mutandis.
The invention will now be further described by way of reference to an Example and a description of a preferred embodiment of the invention in use which is present for the purposes of illustration only and is not to be construed as being limiting on the invention. In the Example and the description of the preferred embodiment, reference is made to a number of drawings in which:
Figure 1- Shows a cross sectional view of the two parts of the pinch punch assembly Figure 2- shows a cross sectional view of the pin punch assembly in its rest position Figure 3 -shows a cross sectional view of the pin punch assembly in its punching position
12 Figure 4- shows a cross sectional view of the pin punch assembly in its resting position after an imprint has been created in the powder Figure 5- shows a cross sectional view of the grooved roll exerting pressure on the pin punch assembly.
Figure 6- shows a comparison of the centring of the core of coated compression tablets when using a classical tooling and the tooling of this invention.
In a preferred embodiment, the invention comprises a tablet press upper punch which is composed of two main parts as shown in Figure 1. The first part is a hollow punch cylinder (1); the second part is a pin (3) which fits exactly inside the punch cylinder (1) and is moveable relative to the punch cylinder (1). The term cylinder is not limited to its geometrical meaning. The pin (3) has a key (5) which limits the movement of the pin (3) within the punch cylinder (1). The head of the key (5) protrudes from the pin (3) and fits into a recess (7) within the housing (1). The pin (3) also has a spring (9) which pushes back the pin (3) to its rest at the opposite end to the punching end where a small raised portion (11) is present.
When the pin punch is in its rest position (as shown in Figure 2), the punching end of the pin (3) is flush with the end of the pin punch housing (1) and the raised portion (11) protrudes from the housing (1) at the opposite end of the pin (3). The pin (3) is prevented from retreating back within the housing (1) by the key (5) hitting the top side of the recess (7). The spring (9) is relaxed.
The pin punch assembly is then positioned so that it contacts the top of the bottom fill powder (19) in the die (17). A roll (13) is in place at the non punching end of the pin (3) and exerts pressure on the raised portion (11) on the pin (3). This pressure moves the pin (3) relative to the housing (1), compressing the spring (9) until the pin (3) protrudes from the housing (1) (Figure 3). As the pin (3) moves, it punches an imprint (21) or a "cup" into the bottom fill. (Figure 4) The size of the imprint (21) is directly
Figure 6- shows a comparison of the centring of the core of coated compression tablets when using a classical tooling and the tooling of this invention.
In a preferred embodiment, the invention comprises a tablet press upper punch which is composed of two main parts as shown in Figure 1. The first part is a hollow punch cylinder (1); the second part is a pin (3) which fits exactly inside the punch cylinder (1) and is moveable relative to the punch cylinder (1). The term cylinder is not limited to its geometrical meaning. The pin (3) has a key (5) which limits the movement of the pin (3) within the punch cylinder (1). The head of the key (5) protrudes from the pin (3) and fits into a recess (7) within the housing (1). The pin (3) also has a spring (9) which pushes back the pin (3) to its rest at the opposite end to the punching end where a small raised portion (11) is present.
When the pin punch is in its rest position (as shown in Figure 2), the punching end of the pin (3) is flush with the end of the pin punch housing (1) and the raised portion (11) protrudes from the housing (1) at the opposite end of the pin (3). The pin (3) is prevented from retreating back within the housing (1) by the key (5) hitting the top side of the recess (7). The spring (9) is relaxed.
The pin punch assembly is then positioned so that it contacts the top of the bottom fill powder (19) in the die (17). A roll (13) is in place at the non punching end of the pin (3) and exerts pressure on the raised portion (11) on the pin (3). This pressure moves the pin (3) relative to the housing (1), compressing the spring (9) until the pin (3) protrudes from the housing (1) (Figure 3). As the pin (3) moves, it punches an imprint (21) or a "cup" into the bottom fill. (Figure 4) The size of the imprint (21) is directly
13 dependent on the size of the pin (3), the depth of the imprint (21) is directly dependent on the height of the raised portion (11) located at the top of the pin (3).
The pin punch then leaves the first roll (13) and the pin (3) is returned to its original position by the action of the spring (9) and the key, which blocks the pin (3) in this position.
The core is then deposited in the imprint (21) and held in the right position by the edges of the imprint. The rest of the press coated tablet external powder is then added.
The final pressure (and pre-pressure) is then applied. At this stage the pin (3) stays in its rest position and the system behaves as a conventional punch (Figure 5).
For the final compression step, the roll (13) has a groove (15) which fits over the raised portion (11) on the pin (3) so that no pressure is applied to the raised portion (11) and the pin (3) does not move relative to the housing (1).
A slight mark can be sometimes observed on the top surface of the press coated tablet revealing the use of a "two piece" punch for its manufacturing.
The apparatus of the invention could be completely dismantled in order to ease cleaning.
Example: Preparation of compression coated tablet and comparison with tablets prepared usinp- a conventional punch The efficacy of the object of the invention was demonstrated by X-ray analysis (Sherlock software) of press coated tablets manufactured on the same tablet press using either conventional punches or punches of the invention.
A set of tablets was produced using the apparatus of the present invention. A
die was filled with a powdered material and a pin punch assembly brought into contact with the powdered material. Pressure was applied to the raised portion on the top of the
The pin punch then leaves the first roll (13) and the pin (3) is returned to its original position by the action of the spring (9) and the key, which blocks the pin (3) in this position.
The core is then deposited in the imprint (21) and held in the right position by the edges of the imprint. The rest of the press coated tablet external powder is then added.
The final pressure (and pre-pressure) is then applied. At this stage the pin (3) stays in its rest position and the system behaves as a conventional punch (Figure 5).
For the final compression step, the roll (13) has a groove (15) which fits over the raised portion (11) on the pin (3) so that no pressure is applied to the raised portion (11) and the pin (3) does not move relative to the housing (1).
A slight mark can be sometimes observed on the top surface of the press coated tablet revealing the use of a "two piece" punch for its manufacturing.
The apparatus of the invention could be completely dismantled in order to ease cleaning.
Example: Preparation of compression coated tablet and comparison with tablets prepared usinp- a conventional punch The efficacy of the object of the invention was demonstrated by X-ray analysis (Sherlock software) of press coated tablets manufactured on the same tablet press using either conventional punches or punches of the invention.
A set of tablets was produced using the apparatus of the present invention. A
die was filled with a powdered material and a pin punch assembly brought into contact with the powdered material. Pressure was applied to the raised portion on the top of the
14 pin, resulting in the movement of the pin into the powder in the bottom fill to create an imprint in the powder. A tablet core was then transferred into the imprint in the powder and further powder added to the die to coat the tablet. The contents of the die were then compressed by the pin punch assembly, without movement of the pin within the housing, to create a compression coated tablet.
A set of tablets was prepared using a conventional punch, for comparison with those produced with the punch as described in the present invention.
A comparison of the obtained results (AC values) is shown in Figure 6. The deviation from the theoretical centre AC is significantly limited when the punch of the invention is used. More than 90% of the tablets are produced with a deviation of the core position by less than 0.3 mm when the tooling of the present invention is used. In comparison, about 15% of the tablets were produced with a deviation from the core position by less than 0.3mm when a conventional tooling was used.
A set of tablets was prepared using a conventional punch, for comparison with those produced with the punch as described in the present invention.
A comparison of the obtained results (AC values) is shown in Figure 6. The deviation from the theoretical centre AC is significantly limited when the punch of the invention is used. More than 90% of the tablets are produced with a deviation of the core position by less than 0.3 mm when the tooling of the present invention is used. In comparison, about 15% of the tablets were produced with a deviation from the core position by less than 0.3mm when a conventional tooling was used.
Claims (6)
1. A method of producing a compression coated tablet, the method comprising the steps of:
(a) filling a die with a first powdered material;
(b) contacting the powdered material in the die with a shaped punch assembly and applying pressure to the punch to create an imprint in the powdered material, the depth of the imprint being less than 1.5 mm, and the punch comprising a housing adapted to receive a pin which is movable within the housing, the pin having a protruding element at one end for engagement with a means for applying pressure to the pin and punch housing, the pin being provided with a torsion means for engagement with the housing, in which the punch has a brake means for retarding movement of the pin in the housing;
wherein the pin is held in a first position by the torsion means to engage the protruding element of the pin with the means for applying pressure, to cause movement of the pin within the housing into the powdered material to create the imprint in the powdered material;
(c) depositing a pm-formed tablet core in the imprint created in the powdered material to form a partly coated compression coated tablet by applying pressure to the punch assembly wherein the pin is held in a second position within the housing by the brake means and the means applying pressure is adapted so as to engage with the housing of the punch only and not to engage with the pin; and optionally (d) introducing a second powdered material into the die on to the upper surface o f the partly coated compression coated tablet; and (e) contacting the second powdered material with the punch and applying pressure to the punch to form a fully coated compression coated tablet, wherein the pin is held in the second position in the housing by the brake means and the means for applying pressure is adapted so as to engage with the housing of the punch only and not to engage with the pin.
(a) filling a die with a first powdered material;
(b) contacting the powdered material in the die with a shaped punch assembly and applying pressure to the punch to create an imprint in the powdered material, the depth of the imprint being less than 1.5 mm, and the punch comprising a housing adapted to receive a pin which is movable within the housing, the pin having a protruding element at one end for engagement with a means for applying pressure to the pin and punch housing, the pin being provided with a torsion means for engagement with the housing, in which the punch has a brake means for retarding movement of the pin in the housing;
wherein the pin is held in a first position by the torsion means to engage the protruding element of the pin with the means for applying pressure, to cause movement of the pin within the housing into the powdered material to create the imprint in the powdered material;
(c) depositing a pm-formed tablet core in the imprint created in the powdered material to form a partly coated compression coated tablet by applying pressure to the punch assembly wherein the pin is held in a second position within the housing by the brake means and the means applying pressure is adapted so as to engage with the housing of the punch only and not to engage with the pin; and optionally (d) introducing a second powdered material into the die on to the upper surface o f the partly coated compression coated tablet; and (e) contacting the second powdered material with the punch and applying pressure to the punch to form a fully coated compression coated tablet, wherein the pin is held in the second position in the housing by the brake means and the means for applying pressure is adapted so as to engage with the housing of the punch only and not to engage with the pin.
2. A method according to any one of claim 1, wherein the protruding element on the pin comprises a raised portion.
3. A method according to any one of claims I or 2 wherein the height of said raised portion determines the depth of the imprint in the powder.
4. A method according to any one of claims 1 to 3 wherein the means for applying pressure comprises a roll.
S. A method according to any one of claims 1 to 4 wherein the means for applying pressure is adaptable to engage with the housing of the punch cylinder only by having a groove which fits over the protruding element of the pin.
6. A method according to any of claims I to 5 wherein the brake means comprise a key which protrudes from the pin and communicates with a recess located in the housing.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0702974.7 | 2007-02-15 | ||
| GBGB0702974.7A GB0702974D0 (en) | 2007-02-15 | 2007-02-15 | Method and apparatus for producing a tablet |
| PCT/IB2008/000648 WO2008099283A2 (en) | 2007-02-15 | 2008-02-15 | Method and apparatus for producing a centred compression coated tablet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2676156A1 CA2676156A1 (en) | 2008-08-21 |
| CA2676156C true CA2676156C (en) | 2016-03-22 |
Family
ID=37908710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2676156A Expired - Fee Related CA2676156C (en) | 2007-02-15 | 2008-02-15 | Method and apparatus for producing a centred compression coated tablet |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8980363B2 (en) |
| EP (1) | EP2121297A2 (en) |
| JP (2) | JP2010519043A (en) |
| KR (1) | KR20090117925A (en) |
| CN (1) | CN101652241A (en) |
| AU (1) | AU2008215838A1 (en) |
| CA (1) | CA2676156C (en) |
| GB (1) | GB0702974D0 (en) |
| WO (1) | WO2008099283A2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5810163B2 (en) * | 2011-08-05 | 2015-11-11 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Tableting punch |
| JP6581427B2 (en) * | 2015-08-06 | 2019-09-25 | サンアロマー株式会社 | Polypropylene resin composition and injection molded product |
| CN107139526B (en) * | 2017-06-27 | 2023-02-17 | 北京东兴堂科技发展有限公司 | Powder tabletting device |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US568488A (en) * | 1896-09-29 | Apparatus for sugar-coating pills | ||
| US2700938A (en) * | 1952-03-19 | 1955-02-01 | Merck & Co Inc | Apparatus and method for tablet production |
| GB743222A (en) * | 1953-05-27 | 1956-01-11 | Thomas Kerfoot & Co Ltd | Improvements in the formation of compressed tablets |
| US2849965A (en) * | 1954-04-15 | 1958-09-02 | John Holroyd & Company Ltd | Machines for use in the production of coated tablets and the like |
| GB818217A (en) * | 1956-10-04 | 1959-08-12 | Thomas Kerfoot & Co Ltd | Improvements in the formation of compressed tablets |
| GB839502A (en) | 1957-01-09 | 1960-06-29 | Kilian And Company G M B H | Method of and apparatus for manufacturing coated tablets |
| US3000331A (en) * | 1957-01-28 | 1961-09-19 | Stokes F J Corp | Coated tablet press |
| US2946298A (en) * | 1957-11-13 | 1960-07-26 | Arthur Colton Company | Compression coating tablet press |
| US3096248A (en) * | 1959-04-06 | 1963-07-02 | Rexall Drug & Chemical Company | Method of making an encapsulated tablet |
| DE1210513B (en) * | 1962-03-22 | 1966-02-10 | Wilhelm Fette Praez Swerkzeug | Method for pressing open-topped shells from shell compound for the production of tablets |
| DE2914201C2 (en) * | 1979-04-07 | 1982-12-02 | Wilhelm Fette Gmbh, 2053 Schwarzenbek | Tablet machine |
| US5088915A (en) * | 1988-06-08 | 1992-02-18 | Korsch Ohg Maschinenfabrik | Coated-core press |
| JPH066149B2 (en) * | 1989-03-16 | 1994-01-26 | 株式会社菊水製作所 | Nucleated molded product |
| US6689305B1 (en) * | 1993-05-05 | 2004-02-10 | Ecolab Inc. | Process for consolidating particulate solids and cleaning products therefrom II |
| US5654005A (en) * | 1995-06-07 | 1997-08-05 | Andrx Pharmaceuticals, Inc. | Controlled release formulation having a preformed passageway |
| CN1052915C (en) * | 1995-11-27 | 2000-05-31 | 中国医学科学院生物医学工程研究所 | Medical carrier of protein coat for carrying gene and its prodn. method |
| GB2362350A (en) * | 2000-05-11 | 2001-11-21 | Reckitt Benekiser N V | Process and press for the production of tablets |
| CA2412173C (en) * | 2000-06-20 | 2010-08-17 | Sanwa Kagaku Kenkyusho Co., Ltd | Nucleated molded article, method of producing the same, and device for producing the same |
| CA2427795A1 (en) * | 2000-11-03 | 2002-05-10 | Control Delivery Systems | Sustained release device for treating conditions of the joint |
| GB0029095D0 (en) * | 2000-11-29 | 2001-01-10 | Reckitt Benckiser Nv | Improvements in or relating to packaging |
| DE60212475T2 (en) * | 2001-03-14 | 2007-07-05 | Pfizer Products Inc., Groton | Pharmaceutical tablet and a process for its preparation |
| KR20030096365A (en) * | 2001-05-07 | 2003-12-24 | 가부시키가이샤 기쿠수이세이사쿠쇼 | Rotary type compression molding machine |
| EP1399309A1 (en) * | 2001-06-25 | 2004-03-24 | Pharmacia Corporation | Compression coated tablets |
| BR0212950A (en) * | 2001-09-28 | 2004-10-26 | Mcneil Ppc Inc | Composite dosage forms having an inserted portion |
| NZ534104A (en) * | 2001-12-24 | 2007-03-30 | Teva Pharma | Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material |
| US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
| JP2007516698A (en) * | 2003-10-06 | 2007-06-28 | セダーズ−シナイ メディカル センター | Use of CXCR4 protein expression on stem cell surface as a marker for tumor-directed potential |
| US8425459B2 (en) * | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| EP1952696A1 (en) * | 2007-02-01 | 2008-08-06 | Nestec S.A. | A method and apparatus for making centre-filled shaped food products |
-
2007
- 2007-02-15 GB GBGB0702974.7A patent/GB0702974D0/en not_active Ceased
-
2008
- 2008-02-15 CN CN200880004911A patent/CN101652241A/en active Pending
- 2008-02-15 KR KR1020097017736A patent/KR20090117925A/en not_active Application Discontinuation
- 2008-02-15 JP JP2009549867A patent/JP2010519043A/en active Pending
- 2008-02-15 CA CA2676156A patent/CA2676156C/en not_active Expired - Fee Related
- 2008-02-15 US US12/527,266 patent/US8980363B2/en not_active Expired - Fee Related
- 2008-02-15 WO PCT/IB2008/000648 patent/WO2008099283A2/en active Application Filing
- 2008-02-15 AU AU2008215838A patent/AU2008215838A1/en not_active Abandoned
- 2008-02-15 EP EP08719335A patent/EP2121297A2/en not_active Ceased
-
2013
- 2013-10-31 JP JP2013226192A patent/JP2014054673A/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008215838A1 (en) | 2008-08-21 |
| JP2010519043A (en) | 2010-06-03 |
| WO2008099283A2 (en) | 2008-08-21 |
| WO2008099283A3 (en) | 2008-11-13 |
| KR20090117925A (en) | 2009-11-16 |
| US8980363B2 (en) | 2015-03-17 |
| CN101652241A (en) | 2010-02-17 |
| WO2008099283A9 (en) | 2009-09-17 |
| JP2014054673A (en) | 2014-03-27 |
| EP2121297A2 (en) | 2009-11-25 |
| GB0702974D0 (en) | 2007-03-28 |
| US20110014352A1 (en) | 2011-01-20 |
| CA2676156A1 (en) | 2008-08-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7625622B2 (en) | Powder compaction and enrobing | |
| CN1671344A (en) | Powder compaction and enrobing | |
| CA2676156C (en) | Method and apparatus for producing a centred compression coated tablet | |
| EP1536934A1 (en) | Method and apparatus for making miniature tablets | |
| AU2013201966B2 (en) | Method and apparatus for producing a centred compression coated tablet | |
| KR20070057977A (en) | Additional improvement in powder compaction and enrobing | |
| AU2013245435A1 (en) | Method and apparatus for producing a centred compression coated tablet | |
| WO2008024406A2 (en) | Tabletting press | |
| EP1944004A2 (en) | Additional improvements in powder compaction and enrobing | |
| Behrens et al. | a piece of cake? |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130204 |
|
| MKLA | Lapsed |
Effective date: 20190215 |