CA2674801A1 - Gene sema6d de susceptibilite au diabete chez l'homme - Google Patents
Gene sema6d de susceptibilite au diabete chez l'homme Download PDFInfo
- Publication number
- CA2674801A1 CA2674801A1 CA002674801A CA2674801A CA2674801A1 CA 2674801 A1 CA2674801 A1 CA 2674801A1 CA 002674801 A CA002674801 A CA 002674801A CA 2674801 A CA2674801 A CA 2674801A CA 2674801 A1 CA2674801 A1 CA 2674801A1
- Authority
- CA
- Canada
- Prior art keywords
- diabetes
- sema6d
- gene
- type
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010012601 diabetes mellitus Diseases 0.000 title description 45
- 108090000623 proteins and genes Proteins 0.000 title description 40
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 102
- 101150090906 Sema6d gene Proteins 0.000 claims abstract description 66
- 238000000034 method Methods 0.000 claims abstract description 62
- 230000004075 alteration Effects 0.000 claims abstract description 30
- 239000012472 biological sample Substances 0.000 claims abstract description 5
- 238000002405 diagnostic procedure Methods 0.000 claims abstract description 5
- 230000035772 mutation Effects 0.000 claims description 44
- 108700028369 Alleles Proteins 0.000 claims description 31
- 102000054766 genetic haplotypes Human genes 0.000 claims description 19
- 208000008589 Obesity Diseases 0.000 claims description 18
- 235000020824 obesity Nutrition 0.000 claims description 17
- 238000009396 hybridization Methods 0.000 claims description 16
- 230000003321 amplification Effects 0.000 claims description 15
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 15
- 238000012163 sequencing technique Methods 0.000 claims description 12
- 238000012217 deletion Methods 0.000 claims description 7
- 230000037430 deletion Effects 0.000 claims description 7
- 238000003780 insertion Methods 0.000 claims description 6
- 230000037431 insertion Effects 0.000 claims description 6
- 108091026890 Coding region Proteins 0.000 claims description 5
- 230000008707 rearrangement Effects 0.000 claims description 3
- 101100210221 Homo sapiens WBP11 gene Proteins 0.000 claims description 2
- 108091092724 Noncoding DNA Proteins 0.000 claims description 2
- 102100028275 WW domain-binding protein 11 Human genes 0.000 claims description 2
- 239000000523 sample Substances 0.000 description 63
- 102100037548 Semaphorin-6D Human genes 0.000 description 39
- 101000739671 Homo sapiens Semaphorin-6D Proteins 0.000 description 38
- 150000007523 nucleic acids Chemical class 0.000 description 24
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 23
- 210000000349 chromosome Anatomy 0.000 description 20
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 20
- 102000039446 nucleic acids Human genes 0.000 description 18
- 108020004707 nucleic acids Proteins 0.000 description 18
- 102000004196 processed proteins & peptides Human genes 0.000 description 18
- 108090000765 processed proteins & peptides Proteins 0.000 description 18
- 229920001184 polypeptide Polymers 0.000 description 16
- 230000014509 gene expression Effects 0.000 description 15
- 108020004414 DNA Proteins 0.000 description 14
- 239000012634 fragment Substances 0.000 description 14
- 238000012360 testing method Methods 0.000 description 14
- 108010029485 Protein Isoforms Proteins 0.000 description 13
- 102000001708 Protein Isoforms Human genes 0.000 description 13
- 239000002773 nucleotide Substances 0.000 description 13
- 125000003729 nucleotide group Chemical group 0.000 description 13
- 208000035180 MODY Diseases 0.000 description 12
- 201000006950 maturity-onset diabetes of the young Diseases 0.000 description 12
- 102000004169 proteins and genes Human genes 0.000 description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 11
- 238000004458 analytical method Methods 0.000 description 11
- 239000008103 glucose Substances 0.000 description 11
- 102000004877 Insulin Human genes 0.000 description 10
- 108090001061 Insulin Proteins 0.000 description 10
- 229940125396 insulin Drugs 0.000 description 10
- 239000003446 ligand Substances 0.000 description 10
- 239000013615 primer Substances 0.000 description 10
- 239000002987 primer (paints) Substances 0.000 description 10
- 238000011282 treatment Methods 0.000 description 10
- 206010022489 Insulin Resistance Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 230000000295 complement effect Effects 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 201000001421 hyperglycemia Diseases 0.000 description 8
- 230000001019 normoglycemic effect Effects 0.000 description 8
- 208000011231 Crohn disease Diseases 0.000 description 7
- 108010021582 Glucokinase Proteins 0.000 description 7
- 102000014105 Semaphorin Human genes 0.000 description 7
- 108050003978 Semaphorin Proteins 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 230000000875 corresponding effect Effects 0.000 description 7
- 238000001514 detection method Methods 0.000 description 7
- 108020004999 messenger RNA Proteins 0.000 description 7
- 244000187656 Eucalyptus cornuta Species 0.000 description 6
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 6
- 206010033307 Overweight Diseases 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 230000018109 developmental process Effects 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 230000002068 genetic effect Effects 0.000 description 6
- 230000003914 insulin secretion Effects 0.000 description 6
- 239000002853 nucleic acid probe Substances 0.000 description 6
- 239000002243 precursor Substances 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 208000002705 Glucose Intolerance Diseases 0.000 description 5
- 102100029237 Hexokinase-4 Human genes 0.000 description 5
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 102000054765 polymorphisms of proteins Human genes 0.000 description 5
- 201000009104 prediabetes syndrome Diseases 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000003127 radioimmunoassay Methods 0.000 description 5
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 description 4
- 101001125026 Homo sapiens Nucleotide-binding oligomerization domain-containing protein 2 Proteins 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 102100029441 Nucleotide-binding oligomerization domain-containing protein 2 Human genes 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000027455 binding Effects 0.000 description 4
- 230000001364 causal effect Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 230000007547 defect Effects 0.000 description 4
- 238000007410 oral glucose tolerance test Methods 0.000 description 4
- 230000002093 peripheral effect Effects 0.000 description 4
- 206010009900 Colitis ulcerative Diseases 0.000 description 3
- 238000009007 Diagnostic Kit Methods 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 3
- 108700024394 Exon Proteins 0.000 description 3
- 108091092878 Microsatellite Proteins 0.000 description 3
- 108020005196 Mitochondrial DNA Proteins 0.000 description 3
- 201000006704 Ulcerative Colitis Diseases 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 230000002939 deleterious effect Effects 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 210000003917 human chromosome Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 108020004635 Complementary DNA Proteins 0.000 description 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 2
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 2
- 108010049606 Hepatocyte Nuclear Factors Proteins 0.000 description 2
- 102000008088 Hepatocyte Nuclear Factors Human genes 0.000 description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 2
- 108010001127 Insulin Receptor Proteins 0.000 description 2
- 108091092195 Intron Proteins 0.000 description 2
- 108700002045 Nod2 Signaling Adaptor Proteins 0.000 description 2
- 102000050697 Nod2 Signaling Adaptor Human genes 0.000 description 2
- 238000000636 Northern blotting Methods 0.000 description 2
- 108020005067 RNA Splice Sites Proteins 0.000 description 2
- 208000001647 Renal Insufficiency Diseases 0.000 description 2
- 108091023040 Transcription factor Proteins 0.000 description 2
- 102000040945 Transcription factor Human genes 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 239000000556 agonist Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 230000004009 axon guidance Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000010804 cDNA synthesis Methods 0.000 description 2
- 230000003915 cell function Effects 0.000 description 2
- 238000007385 chemical modification Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000007824 enzymatic assay Methods 0.000 description 2
- 238000002509 fluorescent in situ hybridization Methods 0.000 description 2
- 230000009395 genetic defect Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 201000006370 kidney failure Diseases 0.000 description 2
- 238000007834 ligase chain reaction Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000000869 mutational effect Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 230000009871 nonspecific binding Effects 0.000 description 2
- 238000003499 nucleic acid array Methods 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 239000002157 polynucleotide Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 208000002249 Diabetes Complications Diseases 0.000 description 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 1
- 206010012655 Diabetic complications Diseases 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000001308 Fasciculation Diseases 0.000 description 1
- 208000003790 Foot Ulcer Diseases 0.000 description 1
- 108091027305 Heteroduplex Proteins 0.000 description 1
- 101100365434 Homo sapiens SEMA6D gene Proteins 0.000 description 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 description 1
- 206010052341 Impaired insulin secretion Diseases 0.000 description 1
- 102000003746 Insulin Receptor Human genes 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 description 1
- 238000003657 Likelihood-ratio test Methods 0.000 description 1
- 238000007476 Maximum Likelihood Methods 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 101100042271 Mus musculus Sema3b gene Proteins 0.000 description 1
- 206010028293 Muscle contractions involuntary Diseases 0.000 description 1
- 101150083031 Nod2 gene Proteins 0.000 description 1
- 108020004485 Nonsense Codon Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108091081062 Repeated sequence (DNA) Proteins 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 101710199476 Semaphorin-6D Proteins 0.000 description 1
- 102300061831 Semaphorin-6D isoform 1 Human genes 0.000 description 1
- 102300061841 Semaphorin-6D isoform 2 Human genes 0.000 description 1
- 102300061840 Semaphorin-6D isoform 3 Human genes 0.000 description 1
- 102300061832 Semaphorin-6D isoform 4 Human genes 0.000 description 1
- 102300061837 Semaphorin-6D isoform 5 Human genes 0.000 description 1
- 102300061836 Semaphorin-6D isoform 6 Human genes 0.000 description 1
- 238000002105 Southern blotting Methods 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- 208000037063 Thinness Diseases 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- 201000010272 acanthosis nigricans Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000007844 allele-specific PCR Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000012098 association analyses Methods 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000012412 chemical coupling Methods 0.000 description 1
- 239000002838 chemorepellent Substances 0.000 description 1
- 230000003609 chemorepellent Effects 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003936 denaturing gel electrophoresis Methods 0.000 description 1
- 208000033679 diabetic kidney disease Diseases 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 231100000221 frame shift mutation induction Toxicity 0.000 description 1
- 230000037433 frameshift Effects 0.000 description 1
- 108091008053 gene clusters Proteins 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 102000054767 gene variant Human genes 0.000 description 1
- 230000004077 genetic alteration Effects 0.000 description 1
- 231100000118 genetic alteration Toxicity 0.000 description 1
- 230000007614 genetic variation Effects 0.000 description 1
- -1 genomic DNA (gDNA) Chemical class 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 208000004104 gestational diabetes Diseases 0.000 description 1
- 230000014101 glucose homeostasis Effects 0.000 description 1
- 230000004190 glucose uptake Effects 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 description 1
- 201000008980 hyperinsulinism Diseases 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 238000009830 intercalation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000004901 leucine-rich repeat Anatomy 0.000 description 1
- 238000011542 limb amputation Methods 0.000 description 1
- 238000007477 logistic regression Methods 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000006371 metabolic abnormality Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 1
- 229960003105 metformin Drugs 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 230000037434 nonsense mutation Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- 229940127017 oral antidiabetic Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 238000001558 permutation test Methods 0.000 description 1
- 230000002974 pharmacogenomic effect Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 231100000815 population-level measure Toxicity 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000009163 protein therapy Methods 0.000 description 1
- 238000003906 pulsed field gel electrophoresis Methods 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000007423 screening assay Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 206010048828 underweight Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88133707P | 2007-01-19 | 2007-01-19 | |
US60/881,337 | 2007-01-19 | ||
PCT/EP2008/050556 WO2008087205A1 (fr) | 2007-01-19 | 2008-01-18 | Gène sema6d de susceptibilité au diabète chez l'homme |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2674801A1 true CA2674801A1 (fr) | 2008-07-24 |
Family
ID=39190252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002674801A Abandoned CA2674801A1 (fr) | 2007-01-19 | 2008-01-18 | Gene sema6d de susceptibilite au diabete chez l'homme |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2102369A1 (fr) |
CA (1) | CA2674801A1 (fr) |
WO (1) | WO2008087205A1 (fr) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004245998A1 (en) * | 2003-06-04 | 2004-12-16 | The Government of the United States as represented by The Secretary of the Department of Health and Human Services, Centres for Disease Control and Prevention | PNI microarray and uses |
-
2008
- 2008-01-18 CA CA002674801A patent/CA2674801A1/fr not_active Abandoned
- 2008-01-18 EP EP08701568A patent/EP2102369A1/fr not_active Withdrawn
- 2008-01-18 WO PCT/EP2008/050556 patent/WO2008087205A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2008087205A1 (fr) | 2008-07-24 |
EP2102369A1 (fr) | 2009-09-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20110129820A1 (en) | Human diabetes susceptibility tnfrsf10b gene | |
WO2011088237A1 (fr) | Procédés d'utilisation de variants génétiques de znf365 pour diagnostiquer la maladie de crohn | |
US9752195B2 (en) | TTC8 as prognostic gene for progressive retinal atrophy in dogs | |
US20100105057A1 (en) | Human diabetes susceptibility tnfrsf10d gene | |
CA2674793A1 (fr) | Gene btbd9 de susceptibilite au diabete humain | |
CA2674801A1 (fr) | Gene sema6d de susceptibilite au diabete chez l'homme | |
US20100285459A1 (en) | Human Diabetes Susceptibility TNFRSF10A gene | |
US20100151462A1 (en) | Human diabetes susceptibility shank2 gene | |
US20110027393A1 (en) | Human diabetes susceptibility eefsec gene | |
US20100203517A1 (en) | Human diabetes susceptibility pebp4 gene | |
US20110003287A1 (en) | Human diabetes susceptibility tnfrsf10c gene | |
CA2674808A1 (fr) | Gene iglc de sensibilite au diabete humain | |
AU2005254806B2 (en) | Human obesity susceptibility gene encoding a potassium voltage-gated channel and uses thereof | |
US20080254450A1 (en) | Human Obesity Susceptibility Genes Encoding Peptide Hormones and Uses Thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |