CA2668338A1 - Inhibiteurs de la serine-threonine proteine kinase ikk-~ - Google Patents

Info

Publication number

CA2668338A1

CA2668338A1 CA002668338A CA2668338A CA2668338A1 CA 2668338 A1 CA2668338 A1 CA 2668338A1 CA 002668338 A CA002668338 A CA 002668338A CA 2668338 A CA2668338 A CA 2668338A CA 2668338 A1 CA2668338 A1 CA 2668338A1

Authority

CA

Canada

Prior art keywords

cyclopentyl

carbamoylamino

carbamoyl

alkyl

optionally substituted

Prior art date

2006-11-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title description 2
• 239000003909 protein kinase inhibitor Substances 0.000 title description 2
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• 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 title 1
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 312
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• 230000000694 effects Effects 0.000 claims abstract description 19
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• 125000004185 ester group Chemical group 0.000 claims abstract description 12
• 125000006413 ring segment Chemical group 0.000 claims abstract description 12
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• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 8
• 108090000371 Esterases Proteins 0.000 claims abstract description 8
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 8
• 125000002843 carboxylic acid group Chemical group 0.000 claims abstract description 8
• 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 8
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• 125000003107 substituted aryl group Chemical group 0.000 claims abstract description 3
• 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 claims abstract 3
• -1 heterocyclic radical Chemical class 0.000 claims description 94
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 89
• 239000000203 mixture Substances 0.000 claims description 58
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 54
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• 238000000034 method Methods 0.000 claims description 36
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 32
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 25
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• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 22
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• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 15
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• 125000002950 monocyclic group Chemical group 0.000 claims description 13
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• DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims description 3
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• 125000006203 morpholinoethyl group Chemical group [H]C([H])(*)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 claims description 2
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
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• 230000009702 cancer cell proliferation Effects 0.000 claims 1
• ACMUIQUUYQXSKA-LYSGITKLSA-N cyclopentyl (2s)-2-[[(e)-3-[4-[4-carbamoyl-5-(carbamoylamino)thiophen-2-yl]phenyl]prop-2-enyl]amino]-4-methylpentanoate Chemical compound N([C@@H](CC(C)C)C(=O)OC1CCCC1)C\C=C\C(C=C1)=CC=C1C1=CC(C(N)=O)=C(NC(N)=O)S1 ACMUIQUUYQXSKA-LYSGITKLSA-N 0.000 claims 1
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