CA2664480A1

CA2664480A1 - Systeme a double electrode pour un capteur de substance a analyser en continu

Systeme a double electrode pour un capteur de substance a analyser en continu Download PDF

Info

Publication number: CA2664480A1
Authority: CA; Canada
Prior art keywords: sensor; working electrode; glucose; electrode; analyte
Prior art date: 2006-10-04
Legal status : Abandoned

Application number

CA002664480A

Other languages

English (en)

Inventor

Mark Brister

Sean Saint

James R. Petisce

Curtis Hanson

Peter Simpson

Jack Pryor

James H. Brauker

Current Assignee

Dexcom Inc

Original Assignee

Individual

Priority date

2006-10-04

Filing date

2006-10-04

Publication date

2008-04-10

2006-10-04 Application filed by Individual filed Critical Individual

2008-04-10 Publication of CA2664480A1 publication Critical patent/CA2664480A1/fr

Status Abandoned legal-status Critical Current

Links

239000012491 analyte Substances 0.000 title claims abstract description 355
230000009977 dual effect Effects 0.000 title description 6
239000008103 glucose Substances 0.000 claims abstract description 582
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 580
238000000034 method Methods 0.000 claims abstract description 92
239000012212 insulator Substances 0.000 claims abstract description 79
238000009792 diffusion process Methods 0.000 claims description 247
230000004888 barrier function Effects 0.000 claims description 195
239000012528 membrane Substances 0.000 claims description 180
150000001875 compounds Chemical class 0.000 claims description 121
230000003647 oxidation Effects 0.000 claims description 99
238000007254 oxidation reaction Methods 0.000 claims description 99
239000012811 non-conductive material Substances 0.000 claims description 95
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 85
238000003780 insertion Methods 0.000 claims description 67
230000037431 insertion Effects 0.000 claims description 67
210000004369 blood Anatomy 0.000 claims description 51
239000008280 blood Substances 0.000 claims description 51
230000002255 enzymatic effect Effects 0.000 claims description 47
230000006870 function Effects 0.000 claims description 41
238000006243 chemical reaction Methods 0.000 claims description 39
230000002452 interceptive effect Effects 0.000 claims description 38
239000000126 substance Substances 0.000 claims description 36
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 34
230000008569 process Effects 0.000 claims description 34
238000001727 in vivo Methods 0.000 claims description 29
238000002513 implantation Methods 0.000 claims description 27
MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 22
230000002123 temporal effect Effects 0.000 claims description 22
125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 20
150000001413 amino acids Chemical class 0.000 claims description 19
239000004202 carbamide Substances 0.000 claims description 18
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 16
206010052428 Wound Diseases 0.000 claims description 13
208000027418 Wounds and injury Diseases 0.000 claims description 13
230000017531 blood circulation Effects 0.000 claims description 13
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 12
239000002243 precursor Substances 0.000 claims description 12
238000007920 subcutaneous administration Methods 0.000 claims description 12
229910019142 PO4 Inorganic materials 0.000 claims description 10
230000029663 wound healing Effects 0.000 claims description 10
230000019522 cellular metabolic process Effects 0.000 claims description 7
230000002378 acidificating effect Effects 0.000 claims description 6
238000005513 bias potential Methods 0.000 claims description 6
235000013877 carbamide Nutrition 0.000 claims description 6
230000015556 catabolic process Effects 0.000 claims description 6
150000001860 citric acid derivatives Chemical class 0.000 claims description 6
235000014655 lactic acid Nutrition 0.000 claims description 6
239000004310 lactic acid Substances 0.000 claims description 6
150000002978 peroxides Chemical class 0.000 claims description 6
235000021317 phosphate Nutrition 0.000 claims description 6
150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 6
125000003396 thiol group Chemical group [H]S* 0.000 claims description 6
238000011144 upstream manufacturing Methods 0.000 claims description 6
125000003277 amino group Chemical group 0.000 claims description 4
239000002840 nitric oxide donor Substances 0.000 claims description 4
230000035945 sensitivity Effects 0.000 abstract description 63
238000005259 measurement Methods 0.000 abstract description 42
238000012545 processing Methods 0.000 abstract description 19
238000001914 filtration Methods 0.000 abstract description 12
102000004190 Enzymes Human genes 0.000 description 208
108090000790 Enzymes Proteins 0.000 description 208
229940088598 enzyme Drugs 0.000 description 208
235000019420 glucose oxidase Nutrition 0.000 description 114
108010015776 Glucose oxidase Proteins 0.000 description 112
239000004366 Glucose oxidase Substances 0.000 description 111
229940116332 glucose oxidase Drugs 0.000 description 111
241000894007 species Species 0.000 description 95
239000001301 oxygen Substances 0.000 description 88
229910052760 oxygen Inorganic materials 0.000 description 88
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 81
239000011810 insulating material Substances 0.000 description 57
230000008859 change Effects 0.000 description 56
239000000243 solution Substances 0.000 description 53
239000000463 material Substances 0.000 description 49
239000000306 component Substances 0.000 description 44
238000000576 coating method Methods 0.000 description 35
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 35
BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 34
229910052709 silver Inorganic materials 0.000 description 32
239000004332 silver Substances 0.000 description 32
230000032258 transport Effects 0.000 description 32
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 31
239000011248 coating agent Substances 0.000 description 31
229920000642 polymer Polymers 0.000 description 31
-1 PreState Chemical compound 0.000 description 21
230000000694 effects Effects 0.000 description 21
229910052751 metal Inorganic materials 0.000 description 21
239000002184 metal Substances 0.000 description 21
239000002904 solvent Substances 0.000 description 21
229910021607 Silver chloride Inorganic materials 0.000 description 20
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 20
HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 20
239000004020 conductor Substances 0.000 description 19
238000000151 deposition Methods 0.000 description 19
238000003618 dip coating Methods 0.000 description 19
238000005507 spraying Methods 0.000 description 19
210000001519 tissue Anatomy 0.000 description 19
229920002301 cellulose acetate Polymers 0.000 description 17
238000013461 design Methods 0.000 description 16
230000006377 glucose transport Effects 0.000 description 16
229910052697 platinum Inorganic materials 0.000 description 16
229920006217 cellulose acetate butyrate Polymers 0.000 description 15
229960005489 paracetamol Drugs 0.000 description 15
229920002635 polyurethane Polymers 0.000 description 14
239000004814 polyurethane Substances 0.000 description 14
235000001014 amino acid Nutrition 0.000 description 13
229920001940 conductive polymer Polymers 0.000 description 13
239000012530 fluid Substances 0.000 description 13
230000001965 increasing effect Effects 0.000 description 13
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 12
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
210000004027 cell Anatomy 0.000 description 12
230000008901 benefit Effects 0.000 description 11
230000008021 deposition Effects 0.000 description 11
239000000047 product Substances 0.000 description 11
230000004044 response Effects 0.000 description 11
102000004877 Insulin Human genes 0.000 description 10
108090001061 Insulin Proteins 0.000 description 10
239000007772 electrode material Substances 0.000 description 10
239000000835 fiber Substances 0.000 description 10
229940125396 insulin Drugs 0.000 description 10
229920000052 poly(p-xylylene) Polymers 0.000 description 10
238000005266 casting Methods 0.000 description 9
229920001577 copolymer Polymers 0.000 description 9
238000001514 detection method Methods 0.000 description 9
206010012601 diabetes mellitus Diseases 0.000 description 9
150000002500 ions Chemical class 0.000 description 9
239000000203 mixture Substances 0.000 description 9
238000012544 monitoring process Methods 0.000 description 9
230000001052 transient effect Effects 0.000 description 9
238000007740 vapor deposition Methods 0.000 description 9
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 8
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 8
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
230000000875 corresponding effect Effects 0.000 description 8
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 8
230000005611 electricity Effects 0.000 description 8
238000003487 electrochemical reaction Methods 0.000 description 8
238000004519 manufacturing process Methods 0.000 description 8
239000002953 phosphate buffered saline Substances 0.000 description 8
230000002829 reductive effect Effects 0.000 description 8
238000007598 dipping method Methods 0.000 description 7
239000006185 dispersion Substances 0.000 description 7
238000006911 enzymatic reaction Methods 0.000 description 7
229920001477 hydrophilic polymer Polymers 0.000 description 7
230000007246 mechanism Effects 0.000 description 7
230000004060 metabolic process Effects 0.000 description 7
229920000036 polyvinylpyrrolidone Polymers 0.000 description 7
239000001267 polyvinylpyrrolidone Substances 0.000 description 7
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 7
210000003462 vein Anatomy 0.000 description 7
LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 6
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
229920003171 Poly (ethylene oxide) Polymers 0.000 description 6
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 6
235000010323 ascorbic acid Nutrition 0.000 description 6
239000011668 ascorbic acid Substances 0.000 description 6
230000001588 bifunctional effect Effects 0.000 description 6
238000004891 communication Methods 0.000 description 6
230000001419 dependent effect Effects 0.000 description 6
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 6
239000003814 drug Substances 0.000 description 6
239000003792 electrolyte Substances 0.000 description 6
238000002474 experimental method Methods 0.000 description 6
210000003722 extracellular fluid Anatomy 0.000 description 6
239000010408 film Substances 0.000 description 6
230000003993 interaction Effects 0.000 description 6
239000004417 polycarbonate Substances 0.000 description 6
229920001296 polysiloxane Polymers 0.000 description 6
239000000376 reactant Substances 0.000 description 6
230000009467 reduction Effects 0.000 description 6
238000012360 testing method Methods 0.000 description 6
239000004721 Polyphenylene oxide Substances 0.000 description 5
230000001594 aberrant effect Effects 0.000 description 5
210000001367 artery Anatomy 0.000 description 5
230000005540 biological transmission Effects 0.000 description 5
229910052799 carbon Inorganic materials 0.000 description 5
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 5
238000005520 cutting process Methods 0.000 description 5
230000007423 decrease Effects 0.000 description 5
229940079593 drug Drugs 0.000 description 5
238000001035 drying Methods 0.000 description 5
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 5
229910052737 gold Inorganic materials 0.000 description 5
239000010931 gold Substances 0.000 description 5
230000002218 hypoglycaemic effect Effects 0.000 description 5
230000001976 improved effect Effects 0.000 description 5
238000009413 insulation Methods 0.000 description 5
230000033001 locomotion Effects 0.000 description 5
230000035800 maturation Effects 0.000 description 5
230000004048 modification Effects 0.000 description 5
238000012986 modification Methods 0.000 description 5
235000018102 proteins Nutrition 0.000 description 5
102000004169 proteins and genes Human genes 0.000 description 5
108090000623 proteins and genes Proteins 0.000 description 5
238000012546 transfer Methods 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 4
CFFZDZCDUFSOFZ-UHFFFAOYSA-N 3,4-Dihydroxy-phenylacetic acid Chemical compound OC(=O)CC1=CC=C(O)C(O)=C1 CFFZDZCDUFSOFZ-UHFFFAOYSA-N 0.000 description 4
BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 4
241000282472 Canis lupus familiaris Species 0.000 description 4
208000013016 Hypoglycemia Diseases 0.000 description 4
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 4
TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 4
230000002411 adverse Effects 0.000 description 4
150000001412 amines Chemical class 0.000 description 4
229960005070 ascorbic acid Drugs 0.000 description 4
239000013060 biological fluid Substances 0.000 description 4
239000012472 biological sample Substances 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
229920001400 block copolymer Polymers 0.000 description 4
235000012000 cholesterol Nutrition 0.000 description 4
229940107161 cholesterol Drugs 0.000 description 4
239000002131 composite material Substances 0.000 description 4
DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
239000013078 crystal Substances 0.000 description 4
238000010586 diagram Methods 0.000 description 4
239000003989 dielectric material Substances 0.000 description 4
125000005442 diisocyanate group Chemical group 0.000 description 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
238000010292 electrical insulation Methods 0.000 description 4
210000003743 erythrocyte Anatomy 0.000 description 4
230000004907 flux Effects 0.000 description 4
229910002804 graphite Inorganic materials 0.000 description 4
239000010439 graphite Substances 0.000 description 4
QRMZSPFSDQBLIX-UHFFFAOYSA-N homovanillic acid Chemical compound COC1=CC(CC(O)=O)=CC=C1O QRMZSPFSDQBLIX-UHFFFAOYSA-N 0.000 description 4
230000002209 hydrophobic effect Effects 0.000 description 4
229910052763 palladium Inorganic materials 0.000 description 4
239000010452 phosphate Substances 0.000 description 4
229920001451 polypropylene glycol Polymers 0.000 description 4
239000010453 quartz Substances 0.000 description 4
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 4
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
235000002639 sodium chloride Nutrition 0.000 description 4
229940116269 uric acid Drugs 0.000 description 4
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 3
XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 3
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 3
241000700721 Hepatitis B virus Species 0.000 description 3
241000713772 Human immunodeficiency virus 1 Species 0.000 description 3
229920000557 Nafion® Polymers 0.000 description 3
239000004642 Polyimide Substances 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
241000700605 Viruses Species 0.000 description 3
239000000956 alloy Substances 0.000 description 3
229910045601 alloy Inorganic materials 0.000 description 3
230000000513 bioprotective effect Effects 0.000 description 3
238000005422 blasting Methods 0.000 description 3
230000000903 blocking effect Effects 0.000 description 3
239000003054 catalyst Substances 0.000 description 3
238000007405 data analysis Methods 0.000 description 3
201000010099 disease Diseases 0.000 description 3
229960003638 dopamine Drugs 0.000 description 3
230000008030 elimination Effects 0.000 description 3
238000003379 elimination reaction Methods 0.000 description 3
NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 3
230000037406 food intake Effects 0.000 description 3
229940050410 gluconate Drugs 0.000 description 3
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 3
238000009499 grossing Methods 0.000 description 3
229940088597 hormone Drugs 0.000 description 3
239000005556 hormone Substances 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
210000002540 macrophage Anatomy 0.000 description 3
206010033675 panniculitis Diseases 0.000 description 3
230000035699 permeability Effects 0.000 description 3
HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical compound [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 description 3
229920001983 poloxamer Polymers 0.000 description 3
229920000570 polyether Polymers 0.000 description 3
229920001721 polyimide Polymers 0.000 description 3
229920001343 polytetrafluoroethylene Polymers 0.000 description 3
239000004810 polytetrafluoroethylene Substances 0.000 description 3
239000000523 sample Substances 0.000 description 3
235000017557 sodium bicarbonate Nutrition 0.000 description 3
229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
230000003068 static effect Effects 0.000 description 3
210000004304 subcutaneous tissue Anatomy 0.000 description 3
239000000758 substrate Substances 0.000 description 3
235000000346 sugar Nutrition 0.000 description 3
230000008093 supporting effect Effects 0.000 description 3
239000010409 thin film Substances 0.000 description 3
XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 3
229920000428 triblock copolymer Polymers 0.000 description 3
YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 description 2
HZCBWYNLGPIQRK-LBPRGKRZSA-N 3,3',5'-triiodo-L-thyronine Chemical compound IC1=CC(C[C@H]([NH3+])C([O-])=O)=CC=C1OC1=CC(I)=C(O)C(I)=C1 HZCBWYNLGPIQRK-LBPRGKRZSA-N 0.000 description 2
DIVQKHQLANKJQO-UHFFFAOYSA-N 3-methoxytyramine Chemical compound COC1=CC(CCN)=CC=C1O DIVQKHQLANKJQO-UHFFFAOYSA-N 0.000 description 2
DUUGKQCEGZLZNO-UHFFFAOYSA-N 5-hydroxyindoleacetic acid Chemical compound C1=C(O)C=C2C(CC(=O)O)=CNC2=C1 DUUGKQCEGZLZNO-UHFFFAOYSA-N 0.000 description 2
102000004452 Arginase Human genes 0.000 description 2
108700024123 Arginases Proteins 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
244000025254 Cannabis sativa Species 0.000 description 2
235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 description 2
235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 description 2
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
102000004420 Creatine Kinase Human genes 0.000 description 2
108010042126 Creatine kinase Proteins 0.000 description 2
108020004414 DNA Proteins 0.000 description 2
101710088194 Dehydrogenase Proteins 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 2
WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 2
WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 2
XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 description 2
NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 2
BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 description 2
239000002033 PVDF binder Substances 0.000 description 2
239000004696 Poly ether ether ketone Substances 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
239000004098 Tetracycline Substances 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
JLRGJRBPOGGCBT-UHFFFAOYSA-N Tolbutamide Chemical compound CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 JLRGJRBPOGGCBT-UHFFFAOYSA-N 0.000 description 2
229910052770 Uranium Inorganic materials 0.000 description 2
108010092464 Urate Oxidase Proteins 0.000 description 2
239000002253 acid Substances 0.000 description 2
230000009471 action Effects 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
239000000427 antigen Substances 0.000 description 2
102000036639 antigens Human genes 0.000 description 2
108091007433 antigens Proteins 0.000 description 2
239000012736 aqueous medium Substances 0.000 description 2
229940072107 ascorbate Drugs 0.000 description 2
125000004429 atom Chemical group 0.000 description 2
210000002457 barrier cell Anatomy 0.000 description 2
239000002585 base Substances 0.000 description 2
230000006399 behavior Effects 0.000 description 2
238000005452 bending Methods 0.000 description 2
230000027455 binding Effects 0.000 description 2
238000009739 binding Methods 0.000 description 2
239000006227 byproduct Substances 0.000 description 2
238000006555 catalytic reaction Methods 0.000 description 2
229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 description 2
238000003486 chemical etching Methods 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
238000005229 chemical vapour deposition Methods 0.000 description 2
229960003920 cocaine Drugs 0.000 description 2
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
238000006482 condensation reaction Methods 0.000 description 2
229910052802 copper Inorganic materials 0.000 description 2
239000010949 copper Substances 0.000 description 2
230000002596 correlated effect Effects 0.000 description 2
229940109239 creatinine Drugs 0.000 description 2
238000004132 cross linking Methods 0.000 description 2
KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 2
238000013500 data storage Methods 0.000 description 2
230000009849 deactivation Effects 0.000 description 2
230000034994 death Effects 0.000 description 2
229940113088 dimethylacetamide Drugs 0.000 description 2
238000010894 electron beam technology Methods 0.000 description 2
229960002179 ephedrine Drugs 0.000 description 2
210000001105 femoral artery Anatomy 0.000 description 2
210000003191 femoral vein Anatomy 0.000 description 2
229960002428 fentanyl Drugs 0.000 description 2
IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 description 2
229920002313 fluoropolymer Polymers 0.000 description 2
239000011888 foil Substances 0.000 description 2
125000000524 functional group Chemical group 0.000 description 2
229920000578 graft copolymer Polymers 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
229920001600 hydrophobic polymer Polymers 0.000 description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
230000003345 hyperglycaemic effect Effects 0.000 description 2
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
229960001680 ibuprofen Drugs 0.000 description 2
230000000415 inactivating effect Effects 0.000 description 2
229910052741 iridium Inorganic materials 0.000 description 2
GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 2
208000028867 ischemia Diseases 0.000 description 2
239000004973 liquid crystal related substance Substances 0.000 description 2
230000007774 longterm Effects 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
239000002609 medium Substances 0.000 description 2
230000005055 memory storage Effects 0.000 description 2
RHCSKNNOAZULRK-UHFFFAOYSA-N mescaline Chemical compound COC1=CC(CCN)=CC(OC)=C1OC RHCSKNNOAZULRK-UHFFFAOYSA-N 0.000 description 2
230000002503 metabolic effect Effects 0.000 description 2
239000002207 metabolite Substances 0.000 description 2
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
229960000482 pethidine Drugs 0.000 description 2
239000008194 pharmaceutical composition Substances 0.000 description 2
JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 2
229950010883 phencyclidine Drugs 0.000 description 2
230000000704 physical effect Effects 0.000 description 2
230000035479 physiological effects, processes and functions Effects 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
239000004033 plastic Substances 0.000 description 2
238000007747 plating Methods 0.000 description 2
229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
229920001707 polybutylene terephthalate Polymers 0.000 description 2
229920000728 polyester Polymers 0.000 description 2
229920002530 polyetherether ketone Polymers 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
229920000139 polyethylene terephthalate Polymers 0.000 description 2
239000005020 polyethylene terephthalate Substances 0.000 description 2
239000002861 polymer material Substances 0.000 description 2
239000004926 polymethyl methacrylate Substances 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
229920002981 polyvinylidene fluoride Polymers 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
PAHGJZDQXIOYTH-UHFFFAOYSA-N pristanic acid Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C(O)=O PAHGJZDQXIOYTH-UHFFFAOYSA-N 0.000 description 2
230000001681 protective effect Effects 0.000 description 2
230000017854 proteolysis Effects 0.000 description 2
QVDSEJDULKLHCG-UHFFFAOYSA-N psilocybin Chemical compound C1=CC(OP(O)(O)=O)=C2C(CCN(C)C)=CNC2=C1 QVDSEJDULKLHCG-UHFFFAOYSA-N 0.000 description 2
230000005855 radiation Effects 0.000 description 2
229920005604 random copolymer Polymers 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 2
229960001860 salicylate Drugs 0.000 description 2
238000007790 scraping Methods 0.000 description 2
238000007650 screen-printing Methods 0.000 description 2
238000007493 shaping process Methods 0.000 description 2
229920005573 silicon-containing polymer Polymers 0.000 description 2
239000007787 solid Substances 0.000 description 2
238000004528 spin coating Methods 0.000 description 2
239000007921 spray Substances 0.000 description 2
238000003860 storage Methods 0.000 description 2
229920001897 terpolymer Polymers 0.000 description 2
229960002180 tetracycline Drugs 0.000 description 2
229930101283 tetracycline Natural products 0.000 description 2
235000019364 tetracycline Nutrition 0.000 description 2
150000003522 tetracyclines Chemical class 0.000 description 2
ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
229940034208 thyroxine Drugs 0.000 description 2
OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 2
229960002277 tolazamide Drugs 0.000 description 2
229960005371 tolbutamide Drugs 0.000 description 2
150000003626 triacylglycerols Chemical class 0.000 description 2
210000002700 urine Anatomy 0.000 description 2
238000004804 winding Methods 0.000 description 2
XEEQGYMUWCZPDN-DOMZBBRYSA-N (-)-(11S,2'R)-erythro-mefloquine Chemical compound C([C@@H]1[C@@H](O)C=2C3=CC=CC(=C3N=C(C=2)C(F)(F)F)C(F)(F)F)CCCN1 XEEQGYMUWCZPDN-DOMZBBRYSA-N 0.000 description 1
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
CIKNYWFPGZCHDL-ZHFUJENKSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[[(2s,3r)-3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;sulfuric acid Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC=C(CN)O2)N)[C@@H](N)C[C@H]1N CIKNYWFPGZCHDL-ZHFUJENKSA-N 0.000 description 1
RLCKHJSFHOZMDR-UHFFFAOYSA-N (3R, 7R, 11R)-1-Phytanoid acid Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)CC(O)=O RLCKHJSFHOZMDR-UHFFFAOYSA-N 0.000 description 1
RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 description 1
UUEZOEBHFHYMGR-RNWHKREASA-N (4r,4ar,7ar,12bs)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;3-(4-chlorophenyl)-n,n-dimethyl-3-pyridin-2-ylpropan-1-amine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1.C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC UUEZOEBHFHYMGR-RNWHKREASA-N 0.000 description 1
PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 description 1
WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 description 1
QNJJECIHYZJXRL-UHFFFAOYSA-N 1-(2-chlorophenyl)-2-methylpropan-2-amine;hydrochloride Chemical compound Cl.CC(C)(N)CC1=CC=CC=C1Cl QNJJECIHYZJXRL-UHFFFAOYSA-N 0.000 description 1
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
QNLDTXPVZPRSAM-UHFFFAOYSA-N 17146-95-1 Chemical compound CC(O)C(O)=O.C1C2=CC=C(O)C=C2C2(C)C(C)C1N(CC=C(C)C)CC2 QNLDTXPVZPRSAM-UHFFFAOYSA-N 0.000 description 1
DBPWSSGDRRHUNT-UHFFFAOYSA-N 17alpha-hydroxy progesterone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C(=O)C)(O)C1(C)CC2 DBPWSSGDRRHUNT-UHFFFAOYSA-N 0.000 description 1
VEPOHXYIFQMVHW-XOZOLZJESA-N 2,3-dihydroxybutanedioic acid (2S,3S)-3,4-dimethyl-2-phenylmorpholine Chemical compound OC(C(O)C(O)=O)C(O)=O.C[C@H]1[C@@H](OCCN1C)c1ccccc1 VEPOHXYIFQMVHW-XOZOLZJESA-N 0.000 description 1
LCZBQMKVFQNSJR-UJPCIWJBSA-N 21-deoxycortisol Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)C[C@@H]2O LCZBQMKVFQNSJR-UJPCIWJBSA-N 0.000 description 1
SHXWCVYOXRDMCX-UHFFFAOYSA-N 3,4-methylenedioxymethamphetamine Chemical compound CNC(C)CC1=CC=C2OCOC2=C1 SHXWCVYOXRDMCX-UHFFFAOYSA-N 0.000 description 1
RLCKHJSFHOZMDR-PWCSWUJKSA-N 3,7R,11R,15-tetramethyl-hexadecanoic acid Chemical compound CC(C)CCC[C@@H](C)CCC[C@@H](C)CCCC(C)CC(O)=O RLCKHJSFHOZMDR-PWCSWUJKSA-N 0.000 description 1
FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
WYEPBHZLDUPIOD-UHFFFAOYSA-N 4,6-dioxoheptanoic acid Chemical compound CC(=O)CC(=O)CCC(O)=O WYEPBHZLDUPIOD-UHFFFAOYSA-N 0.000 description 1
101710169336 5'-deoxyadenosine deaminase Proteins 0.000 description 1
CWSZBVAUYPTXTG-UHFFFAOYSA-N 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OCCO)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 CWSZBVAUYPTXTG-UHFFFAOYSA-N 0.000 description 1
RVWZUOPFHTYIEO-UHFFFAOYSA-N 5-hydroxyindoleacetic acid Natural products C1=C(O)C=C2C(C(=O)O)=CNC2=C1 RVWZUOPFHTYIEO-UHFFFAOYSA-N 0.000 description 1
239000003310 5-hydroxyindoleacetic acid Substances 0.000 description 1
108010024223 Adenine phosphoribosyltransferase Proteins 0.000 description 1
102100029457 Adenine phosphoribosyltransferase Human genes 0.000 description 1
102100036664 Adenosine deaminase Human genes 0.000 description 1
BYXHQQCXAJARLQ-ZLUOBGJFSA-N Ala-Ala-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O BYXHQQCXAJARLQ-ZLUOBGJFSA-N 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
108010021809 Alcohol dehydrogenase Proteins 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
RLFWWDJHLFCNIJ-UHFFFAOYSA-N Aminoantipyrine Natural products CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
208000012657 Atopic disease Diseases 0.000 description 1
KZFBHCCLJSAHBQ-UHFFFAOYSA-N Benzoylecgonine Natural products CN1C2CCC1C(C(C2)OC(=C)c3ccccc3)C(=O)O KZFBHCCLJSAHBQ-UHFFFAOYSA-N 0.000 description 1
108010039206 Biotinidase Proteins 0.000 description 1
102100026044 Biotinidase Human genes 0.000 description 1
JQJPBYFTQAANLE-UHFFFAOYSA-N Butyl nitrite Chemical compound CCCCON=O JQJPBYFTQAANLE-UHFFFAOYSA-N 0.000 description 1
108010074051 C-Reactive Protein Proteins 0.000 description 1
102100032752 C-reactive protein Human genes 0.000 description 1
KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 description 1
108010033547 Carbonic Anhydrase I Proteins 0.000 description 1
102100025518 Carbonic anhydrase 1 Human genes 0.000 description 1
229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
229920008347 Cellulose acetate propionate Polymers 0.000 description 1
108010075016 Ceruloplasmin Proteins 0.000 description 1
102100023321 Ceruloplasmin Human genes 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
239000004380 Cholic acid Substances 0.000 description 1
102000003914 Cholinesterases Human genes 0.000 description 1
108090000322 Cholinesterases Proteins 0.000 description 1
235000001258 Cinchona calisaya Nutrition 0.000 description 1
206010010071 Coma Diseases 0.000 description 1
229930105110 Cyclosporin A Natural products 0.000 description 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
108010036949 Cyclosporine Proteins 0.000 description 1
201000003808 Cystic echinococcosis Diseases 0.000 description 1
201000003883 Cystic fibrosis Diseases 0.000 description 1
108010071840 Cytosol nonspecific dipeptidase Proteins 0.000 description 1
HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical class OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 description 1
LHQIJBMDNUYRAM-AWFVSMACSA-N D-erythro-biopterin Chemical compound N1=C(N)NC(=O)C2=NC([C@H](O)[C@H](O)C)=CN=C21 LHQIJBMDNUYRAM-AWFVSMACSA-N 0.000 description 1
VVNCNSJFMMFHPL-VKHMYHEASA-N D-penicillamine Chemical compound CC(C)(S)[C@@H](N)C(O)=O VVNCNSJFMMFHPL-VKHMYHEASA-N 0.000 description 1
241000725619 Dengue virus Species 0.000 description 1
108010028196 Dihydropteridine Reductase Proteins 0.000 description 1
102100022317 Dihydropteridine reductase Human genes 0.000 description 1
241001319090 Dracunculus medinensis Species 0.000 description 1
206010013801 Duchenne Muscular Dystrophy Diseases 0.000 description 1
241000244170 Echinococcus granulosus Species 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
241000224432 Entamoeba histolytica Species 0.000 description 1
241000709661 Enterovirus Species 0.000 description 1
241000991587 Enterovirus C Species 0.000 description 1
JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
102100029115 Fumarylacetoacetase Human genes 0.000 description 1
108091081406 G-quadruplex Proteins 0.000 description 1
108010015133 Galactose oxidase Proteins 0.000 description 1
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
229930182566 Gentamicin Natural products 0.000 description 1
241000224466 Giardia Species 0.000 description 1
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
108010024636 Glutathione Proteins 0.000 description 1
102000017011 Glycated Hemoglobin A Human genes 0.000 description 1
108010014663 Glycated Hemoglobin A Proteins 0.000 description 1
108010007979 Glycocholic Acid Proteins 0.000 description 1
FOHHNHSLJDZUGQ-VWLOTQADSA-N Halofantrine Chemical compound FC(F)(F)C1=CC=C2C([C@@H](O)CCN(CCCC)CCCC)=CC3=C(Cl)C=C(Cl)C=C3C2=C1 FOHHNHSLJDZUGQ-VWLOTQADSA-N 0.000 description 1
239000004866 Hashish Substances 0.000 description 1
241000590002 Helicobacter pylori Species 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
208000032087 Hereditary Leber Optic Atrophy Diseases 0.000 description 1
GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
102000016871 Hexosaminidase A Human genes 0.000 description 1
108010053317 Hexosaminidase A Proteins 0.000 description 1
241000282412 Homo Species 0.000 description 1
241000714260 Human T-lymphotropic virus 1 Species 0.000 description 1
241000701024 Human betaherpesvirus 5 Species 0.000 description 1
108010056651 Hydroxymethylbilane synthase Proteins 0.000 description 1
DOMWKUIIPQCAJU-LJHIYBGHSA-N Hydroxyprogesterone caproate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)CCCCC)[C@@]1(C)CC2 DOMWKUIIPQCAJU-LJHIYBGHSA-N 0.000 description 1
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
108010093096 Immobilized Enzymes Proteins 0.000 description 1
108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
102100037852 Insulin-like growth factor I Human genes 0.000 description 1
108010044467 Isoenzymes Proteins 0.000 description 1
ZAGRKAFMISFKIO-UHFFFAOYSA-N Isolysergic acid Natural products C1=CC(C2=CC(CN(C2C2)C)C(O)=O)=C3C2=CNC3=C1 ZAGRKAFMISFKIO-UHFFFAOYSA-N 0.000 description 1
240000007049 Juglans regia Species 0.000 description 1
235000009496 Juglans regia Nutrition 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
229930064664 L-arginine Natural products 0.000 description 1
235000014852 L-arginine Nutrition 0.000 description 1
LHQIJBMDNUYRAM-UHFFFAOYSA-N L-erythro-Biopterin Natural products N1=C(N)NC(=O)C2=NC(C(O)C(O)C)=CN=C21 LHQIJBMDNUYRAM-UHFFFAOYSA-N 0.000 description 1
FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 description 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
201000000639 Leber hereditary optic neuropathy Diseases 0.000 description 1
241000222727 Leishmania donovani Species 0.000 description 1
241000589902 Leptospira Species 0.000 description 1
102000004895 Lipoproteins Human genes 0.000 description 1
108090001030 Lipoproteins Proteins 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
241000883511 Lophophora williamsii Species 0.000 description 1
201000005505 Measles Diseases 0.000 description 1
JEYCTXHKTXCGPB-UHFFFAOYSA-N Methaqualone Chemical compound CC1=CC=CC=C1N1C(=O)C2=CC=CC=C2N=C1C JEYCTXHKTXCGPB-UHFFFAOYSA-N 0.000 description 1
208000005647 Mumps Diseases 0.000 description 1
102000016943 Muramidase Human genes 0.000 description 1
108010014251 Muramidase Proteins 0.000 description 1
241000186362 Mycobacterium leprae Species 0.000 description 1
241000202934 Mycoplasma pneumoniae Species 0.000 description 1
102100030856 Myoglobin Human genes 0.000 description 1
108010062374 Myoglobin Proteins 0.000 description 1
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
RFDAIACWWDREDC-UHFFFAOYSA-N Na salt-Glycocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCC(O)=O)C)C1(C)C(O)C2 RFDAIACWWDREDC-UHFFFAOYSA-N 0.000 description 1
206010029113 Neovascularisation Diseases 0.000 description 1
241000243985 Onchocerca volvulus Species 0.000 description 1
239000008896 Opium Substances 0.000 description 1
108090000854 Oxidoreductases Proteins 0.000 description 1
102000004316 Oxidoreductases Human genes 0.000 description 1
102000019280 Pancreatic lipases Human genes 0.000 description 1
108050006759 Pancreatic lipases Proteins 0.000 description 1
208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 1
241000223960 Plasmodium falciparum Species 0.000 description 1
241000223810 Plasmodium vivax Species 0.000 description 1
229920000463 Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) Polymers 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
102100034391 Porphobilinogen deaminase Human genes 0.000 description 1
CZWCKYRVOZZJNM-UHFFFAOYSA-N Prasterone sodium sulfate Natural products C1C(OS(O)(=O)=O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 CZWCKYRVOZZJNM-UHFFFAOYSA-N 0.000 description 1
101710101148 Probable 6-oxopurine nucleoside phosphorylase Proteins 0.000 description 1
102000003946 Prolactin Human genes 0.000 description 1
108010057464 Prolactin Proteins 0.000 description 1
GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
241000589517 Pseudomonas aeruginosa Species 0.000 description 1
102000030764 Purine-nucleoside phosphorylase Human genes 0.000 description 1
208000001647 Renal Insufficiency Diseases 0.000 description 1
241000725643 Respiratory syncytial virus Species 0.000 description 1
241000606701 Rickettsia Species 0.000 description 1
MEFKEPWMEQBLKI-AIRLBKTGSA-O S-adenosyl-L-methionine Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H]([NH3+])C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-O 0.000 description 1
241000242680 Schistosoma mansoni Species 0.000 description 1
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
206010040943 Skin Ulcer Diseases 0.000 description 1
206010040860 Skin haemorrhages Diseases 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
229910000831 Steel Inorganic materials 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
241000701093 Suid alphaherpesvirus 1 Species 0.000 description 1
PJSFRIWCGOHTNF-UHFFFAOYSA-N Sulphormetoxin Chemical compound COC1=NC=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=C1OC PJSFRIWCGOHTNF-UHFFFAOYSA-N 0.000 description 1
CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 description 1
AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
102000011923 Thyrotropin Human genes 0.000 description 1
108010061174 Thyrotropin Proteins 0.000 description 1
102000002248 Thyroxine-Binding Globulin Human genes 0.000 description 1
108010000259 Thyroxine-Binding Globulin Proteins 0.000 description 1
241000223997 Toxoplasma gondii Species 0.000 description 1
102000004357 Transferases Human genes 0.000 description 1
108090000992 Transferases Proteins 0.000 description 1
102000004338 Transferrin Human genes 0.000 description 1
108090000901 Transferrin Proteins 0.000 description 1
241000223104 Trypanosoma Species 0.000 description 1
102000004142 Trypsin Human genes 0.000 description 1
108090000631 Trypsin Proteins 0.000 description 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
102100021436 UDP-glucose 4-epimerase Human genes 0.000 description 1
108010075202 UDP-glucose 4-epimerase Proteins 0.000 description 1
108010082433 UDP-glucose-hexose-1-phosphate uridylyltransferase Proteins 0.000 description 1
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
241000244005 Wuchereria bancrofti Species 0.000 description 1
102100039662 Xaa-Pro dipeptidase Human genes 0.000 description 1
241000710772 Yellow fever virus Species 0.000 description 1
BPKGOZPBGXJDEP-UHFFFAOYSA-N [C].[Zn] Chemical compound [C].[Zn] BPKGOZPBGXJDEP-UHFFFAOYSA-N 0.000 description 1
FBDMJGHBCPNRGF-UHFFFAOYSA-M [OH-].[Li+].[O-2].[Mn+2] Chemical group [OH-].[Li+].[O-2].[Mn+2] FBDMJGHBCPNRGF-UHFFFAOYSA-M 0.000 description 1
108010063628 acarboxyprothrombin Proteins 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
230000006978 adaptation Effects 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
108010050122 alpha 1-Antitrypsin Proteins 0.000 description 1
102000015395 alpha 1-Antitrypsin Human genes 0.000 description 1
229940024142 alpha 1-antitrypsin Drugs 0.000 description 1
108010026331 alpha-Fetoproteins Proteins 0.000 description 1
102000013529 alpha-Fetoproteins Human genes 0.000 description 1
230000004075 alteration Effects 0.000 description 1
229920005603 alternating copolymer Polymers 0.000 description 1
125000000539 amino acid group Chemical group 0.000 description 1
229960003116 amyl nitrite Drugs 0.000 description 1
239000003263 anabolic agent Substances 0.000 description 1
229940070021 anabolic steroids Drugs 0.000 description 1
230000003460 anti-nuclear Effects 0.000 description 1
239000003472 antidiabetic agent Substances 0.000 description 1
VEQOALNAAJBPNY-UHFFFAOYSA-N antipyrine Chemical compound CN1C(C)=CC(=O)N1C1=CC=CC=C1 VEQOALNAAJBPNY-UHFFFAOYSA-N 0.000 description 1
208000008784 apnea Diseases 0.000 description 1
238000013459 approach Methods 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
235000009697 arginine Nutrition 0.000 description 1
238000003556 assay Methods 0.000 description 1
238000001505 atmospheric-pressure chemical vapour deposition Methods 0.000 description 1
238000000277 atomic layer chemical vapour deposition Methods 0.000 description 1
ANFSNXAXVLRZCG-RSAXXLAASA-N benzphetamine hydrochloride Chemical compound [Cl-].C([C@H](C)[NH+](C)CC=1C=CC=CC=1)C1=CC=CC=C1 ANFSNXAXVLRZCG-RSAXXLAASA-N 0.000 description 1
208000005980 beta thalassemia Diseases 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
239000012503 blood component Substances 0.000 description 1
238000009534 blood test Methods 0.000 description 1
210000004204 blood vessel Anatomy 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000013590 bulk material Substances 0.000 description 1
OJIJEKBXJYRIBZ-UHFFFAOYSA-N cadmium nickel Chemical compound [Ni].[Cd] OJIJEKBXJYRIBZ-UHFFFAOYSA-N 0.000 description 1
229940075397 calomel Drugs 0.000 description 1
239000003990 capacitor Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
150000007942 carboxylates Chemical class 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
229960004203 carnitine Drugs 0.000 description 1
229940081734 cellulose acetate phthalate Drugs 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
229910010293 ceramic material Inorganic materials 0.000 description 1
210000001175 cerebrospinal fluid Anatomy 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
239000013043 chemical agent Substances 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 description 1
229960001091 chenodeoxycholic acid Drugs 0.000 description 1
ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 description 1
229960003677 chloroquine Drugs 0.000 description 1
WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 description 1
229960002471 cholic acid Drugs 0.000 description 1
229940048961 cholinesterase Drugs 0.000 description 1
229960001265 ciclosporin Drugs 0.000 description 1
LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
239000008199 coating composition Substances 0.000 description 1
229960004126 codeine Drugs 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000011109 contamination Methods 0.000 description 1
230000008094 contradictory effect Effects 0.000 description 1
239000002872 contrast media Substances 0.000 description 1
230000001276 controlling effect Effects 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
230000008878 coupling Effects 0.000 description 1
238000010168 coupling process Methods 0.000 description 1
238000005859 coupling reaction Methods 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
CZWCKYRVOZZJNM-USOAJAOKSA-N dehydroepiandrosterone sulfate Chemical compound C1[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 CZWCKYRVOZZJNM-USOAJAOKSA-N 0.000 description 1
230000032798 delamination Effects 0.000 description 1
CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 1
229920000736 dendritic polymer Polymers 0.000 description 1
238000005137 deposition process Methods 0.000 description 1
239000000747 designer drug Substances 0.000 description 1
QMQBBUPJKANITL-MYXGOWFTSA-N dextropropoxyphene hydrochloride Chemical compound [H+].[Cl-].C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 QMQBBUPJKANITL-MYXGOWFTSA-N 0.000 description 1
229960002069 diamorphine Drugs 0.000 description 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
229920000359 diblock copolymer Polymers 0.000 description 1
229940120144 didrex Drugs 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
230000004069 differentiation Effects 0.000 description 1
KIQKWYUGPPFMBV-UHFFFAOYSA-N diisocyanatomethane Chemical compound O=C=NCN=C=O KIQKWYUGPPFMBV-UHFFFAOYSA-N 0.000 description 1
ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 1
HYPPXZBJBPSRLK-UHFFFAOYSA-N diphenoxylate Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 HYPPXZBJBPSRLK-UHFFFAOYSA-N 0.000 description 1
QCHSEDTUUKDTIG-UHFFFAOYSA-L dipotassium clorazepate Chemical compound [OH-].[K+].[K+].C12=CC(Cl)=CC=C2NC(=O)C(C(=O)[O-])N=C1C1=CC=CC=C1 QCHSEDTUUKDTIG-UHFFFAOYSA-L 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
229960004242 dronabinol Drugs 0.000 description 1
GVGYEFKIHJTNQZ-RFQIPJPRSA-N ecgonine benzoate Chemical compound O([C@@H]1[C@@H]([C@H]2CC[C@@H](C1)N2C)C(O)=O)C(=O)C1=CC=CC=C1 GVGYEFKIHJTNQZ-RFQIPJPRSA-N 0.000 description 1
239000012777 electrically insulating material Substances 0.000 description 1
239000008151 electrolyte solution Substances 0.000 description 1
239000012992 electron transfer agent Substances 0.000 description 1
238000009713 electroplating Methods 0.000 description 1
238000004924 electrostatic deposition Methods 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
229940007078 entamoeba histolytica Drugs 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
238000011067 equilibration Methods 0.000 description 1
229920000840 ethylene tetrafluoroethylene copolymer Polymers 0.000 description 1
230000004438 eyesight Effects 0.000 description 1
239000003925 fat Substances 0.000 description 1
235000019197 fats Nutrition 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
238000013100 final test Methods 0.000 description 1
235000012631 food intake Nutrition 0.000 description 1
210000000245 forearm Anatomy 0.000 description 1
210000003194 forelimb Anatomy 0.000 description 1
239000000446 fuel Substances 0.000 description 1
108010022687 fumarylacetoacetase Proteins 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
229960002518 gentamicin Drugs 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000010030 glucose lowering effect Effects 0.000 description 1
229960003180 glutathione Drugs 0.000 description 1
RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 description 1
229940099347 glycocholic acid Drugs 0.000 description 1
239000000380 hallucinogen Substances 0.000 description 1
229960003242 halofantrine Drugs 0.000 description 1
230000035876 healing Effects 0.000 description 1
230000036541 health Effects 0.000 description 1
208000019622 heart disease Diseases 0.000 description 1
229940037467 helicobacter pylori Drugs 0.000 description 1
208000034737 hemoglobinopathy Diseases 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
230000003284 homeostatic effect Effects 0.000 description 1
229920001519 homopolymer Polymers 0.000 description 1
230000007412 host metabolism Effects 0.000 description 1
238000004050 hot filament vapor deposition Methods 0.000 description 1
229940084986 human chorionic gonadotropin Drugs 0.000 description 1
239000003906 humectant Substances 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
229960000890 hydrocortisone Drugs 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
JUMYIBMBTDDLNG-OJERSXHUSA-N hydron;methyl (2r)-2-phenyl-2-[(2r)-piperidin-2-yl]acetate;chloride Chemical compound Cl.C([C@@H]1[C@H](C(=O)OC)C=2C=CC=CC=2)CCCN1 JUMYIBMBTDDLNG-OJERSXHUSA-N 0.000 description 1
229920001480 hydrophilic copolymer Polymers 0.000 description 1
229920013746 hydrophilic polyethylene oxide Polymers 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
229950000801 hydroxyprogesterone caproate Drugs 0.000 description 1
201000001421 hyperglycemia Diseases 0.000 description 1
238000003384 imaging method Methods 0.000 description 1
230000028993 immune response Effects 0.000 description 1
238000007373 indentation Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
238000001802 infusion Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
208000018337 inherited hemoglobinopathy Diseases 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
229920000592 inorganic polymer Polymers 0.000 description 1
239000012774 insulation material Substances 0.000 description 1
229940127560 insulin pen Drugs 0.000 description 1
125000003010 ionic group Chemical group 0.000 description 1
230000001678 irradiating effect Effects 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
208000017169 kidney disease Diseases 0.000 description 1
201000006370 kidney failure Diseases 0.000 description 1
239000008101 lactose Substances 0.000 description 1
238000000608 laser ablation Methods 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
229910001416 lithium ion Inorganic materials 0.000 description 1
229940087973 lomotil Drugs 0.000 description 1
239000013627 low molecular weight specie Substances 0.000 description 1
238000004518 low pressure chemical vapour deposition Methods 0.000 description 1
210000004880 lymph fluid Anatomy 0.000 description 1
ZAGRKAFMISFKIO-QMTHXVAHSA-N lysergic acid Chemical compound C1=CC(C2=C[C@H](CN([C@@H]2C2)C)C(O)=O)=C3C2=CNC3=C1 ZAGRKAFMISFKIO-QMTHXVAHSA-N 0.000 description 1
239000004325 lysozyme Substances 0.000 description 1
229960000274 lysozyme Drugs 0.000 description 1
235000010335 lysozyme Nutrition 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
230000007257 malfunction Effects 0.000 description 1
240000004308 marijuana Species 0.000 description 1
230000000873 masking effect Effects 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
229960001962 mefloquine Drugs 0.000 description 1
229910052987 metal hydride Inorganic materials 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
229960002803 methaqualone Drugs 0.000 description 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
238000000259 microwave plasma-assisted chemical vapour deposition Methods 0.000 description 1
238000001451 molecular beam epitaxy Methods 0.000 description 1
238000012806 monitoring device Methods 0.000 description 1
229960005181 morphine Drugs 0.000 description 1
208000010805 mumps infectious disease Diseases 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
FYHCHSNOXWVJJT-UHFFFAOYSA-N n-debutylhalofantrine Chemical compound FC(F)(F)C1=CC=C2C(C(O)CCNCCCC)=CC3=C(Cl)C=C(Cl)C=C3C2=C1 FYHCHSNOXWVJJT-UHFFFAOYSA-N 0.000 description 1
CSDTZUBPSYWZDX-UHFFFAOYSA-N n-pentyl nitrite Chemical compound CCCCCON=O CSDTZUBPSYWZDX-UHFFFAOYSA-N 0.000 description 1
239000004081 narcotic agent Substances 0.000 description 1
229920005615 natural polymer Polymers 0.000 description 1
229960000808 netilmicin Drugs 0.000 description 1
ZBGPYVZLYBDXKO-HILBYHGXSA-N netilmycin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@]([C@H](NC)[C@@H](O)CO1)(C)O)NCC)[C@H]1OC(CN)=CC[C@H]1N ZBGPYVZLYBDXKO-HILBYHGXSA-N 0.000 description 1
230000001722 neurochemical effect Effects 0.000 description 1
201000001119 neuropathy Diseases 0.000 description 1
230000007823 neuropathy Effects 0.000 description 1
229960002715 nicotine Drugs 0.000 description 1
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000001272 nitrous oxide Substances 0.000 description 1
239000000615 nonconductor Substances 0.000 description 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
229960002748 norepinephrine Drugs 0.000 description 1
229960001027 opium Drugs 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
230000010355 oscillation Effects 0.000 description 1
ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 description 1
238000006395 oxidase reaction Methods 0.000 description 1
SJEFKIVIMJHMLR-UHFFFAOYSA-N oxomercury;zinc Chemical compound [Zn].[Hg]=O SJEFKIVIMJHMLR-UHFFFAOYSA-N 0.000 description 1
238000007649 pad printing Methods 0.000 description 1
238000010422 painting Methods 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
229940116369 pancreatic lipase Drugs 0.000 description 1
239000002245 particle Substances 0.000 description 1
NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 description 1
229960001639 penicillamine Drugs 0.000 description 1
229940011043 percocet Drugs 0.000 description 1
208000033808 peripheral neuropathy Diseases 0.000 description 1
229960005222 phenazone Drugs 0.000 description 1
OOBHFESNSZDWIU-UHFFFAOYSA-N phenmetrazine Chemical compound CC1NCCOC1C1=CC=CC=C1 OOBHFESNSZDWIU-UHFFFAOYSA-N 0.000 description 1
DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
229960002695 phenobarbital Drugs 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
229960002036 phenytoin Drugs 0.000 description 1
238000000206 photolithography Methods 0.000 description 1
238000005240 physical vapour deposition Methods 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
238000000623 plasma-assisted chemical vapour deposition Methods 0.000 description 1
238000005498 polishing Methods 0.000 description 1
229920002492 poly(sulfone) Polymers 0.000 description 1
239000004584 polyacrylic acid Substances 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
229920000098 polyolefin Polymers 0.000 description 1
229920005606 polypropylene copolymer Polymers 0.000 description 1
229920003226 polyurethane urea Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
239000011148 porous material Substances 0.000 description 1
150000004032 porphyrins Chemical class 0.000 description 1
230000001144 postural effect Effects 0.000 description 1
229950009829 prasterone sulfate Drugs 0.000 description 1
238000003825 pressing Methods 0.000 description 1
238000007639 printing Methods 0.000 description 1
239000000186 progesterone Substances 0.000 description 1
229960003387 progesterone Drugs 0.000 description 1
229940097325 prolactin Drugs 0.000 description 1
108010066823 proline dipeptidase Proteins 0.000 description 1
229950003776 protoporphyrin Drugs 0.000 description 1
238000004549 pulsed laser deposition Methods 0.000 description 1
229960000948 quinine Drugs 0.000 description 1
238000001289 rapid thermal chemical vapour deposition Methods 0.000 description 1
238000005546 reactive sputtering Methods 0.000 description 1
238000000663 remote plasma-enhanced chemical vapour deposition Methods 0.000 description 1
238000009877 rendering Methods 0.000 description 1
229940099204 ritalin Drugs 0.000 description 1
201000005404 rubella Diseases 0.000 description 1
108010093322 s-formylglutathione hydrolase Proteins 0.000 description 1
102000028528 s-formylglutathione hydrolase Human genes 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000004576 sand Substances 0.000 description 1
206010039766 scrub typhus Diseases 0.000 description 1
229910052711 selenium Inorganic materials 0.000 description 1
239000011669 selenium Substances 0.000 description 1
238000004092 self-diagnosis Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
230000008054 signal transmission Effects 0.000 description 1
BSWGGJHLVUUXTL-UHFFFAOYSA-N silver zinc Chemical compound [Zn].[Ag] BSWGGJHLVUUXTL-UHFFFAOYSA-N 0.000 description 1
238000004513 sizing Methods 0.000 description 1
231100000019 skin ulcer Toxicity 0.000 description 1
239000012453 solvate Substances 0.000 description 1
230000005236 sound signal Effects 0.000 description 1
238000004544 sputter deposition Methods 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000010959 steel Substances 0.000 description 1
239000000021 stimulant Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
229960004673 sulfadoxine Drugs 0.000 description 1
230000003319 supportive effect Effects 0.000 description 1
238000006557 surface reaction Methods 0.000 description 1
210000004243 sweat Anatomy 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229940066690 talwin Drugs 0.000 description 1
210000001138 tear Anatomy 0.000 description 1
229960005367 tetanus antitoxin Drugs 0.000 description 1
229920006029 tetra-polymer Polymers 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
229960000278 theophylline Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000002207 thermal evaporation Methods 0.000 description 1
229920001187 thermosetting polymer Polymers 0.000 description 1
229960000874 thyrotropin Drugs 0.000 description 1
230000001748 thyrotropin Effects 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
239000003204 tranquilizing agent Substances 0.000 description 1
230000002936 tranquilizing effect Effects 0.000 description 1
LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
239000012581 transferrin Substances 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
229940063648 tranxene Drugs 0.000 description 1
230000004102 tricarboxylic acid cycle Effects 0.000 description 1
229940035722 triiodothyronine Drugs 0.000 description 1
125000005591 trimellitate group Chemical group 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
229940071950 tussionex Drugs 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
238000000038 ultrahigh vacuum chemical vapour deposition Methods 0.000 description 1
238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
241000701161 unidentified adenovirus Species 0.000 description 1
241001529453 unidentified herpesvirus Species 0.000 description 1
241000712461 unidentified influenza virus Species 0.000 description 1
229940072690 valium Drugs 0.000 description 1
238000005019 vapor deposition process Methods 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
238000004073 vulcanization Methods 0.000 description 1
235000020234 walnut Nutrition 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
229940051021 yellow-fever virus Drugs 0.000 description 1
FUTVBRXUIKZACV-UHFFFAOYSA-L zinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid Chemical compound [Zn+2].[N-]1C(C=C2C(=C(C=C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)C)=C(C)C(CCC(O)=O)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 FUTVBRXUIKZACV-UHFFFAOYSA-L 0.000 description 1