CA2661099A1 - Pharmaceutical compositions comprising cefquinome - Google Patents
Pharmaceutical compositions comprising cefquinome Download PDFInfo
- Publication number
- CA2661099A1 CA2661099A1 CA002661099A CA2661099A CA2661099A1 CA 2661099 A1 CA2661099 A1 CA 2661099A1 CA 002661099 A CA002661099 A CA 002661099A CA 2661099 A CA2661099 A CA 2661099A CA 2661099 A1 CA2661099 A1 CA 2661099A1
- Authority
- CA
- Canada
- Prior art keywords
- composition according
- cefquinome
- cetostearyl ether
- macrogol cetostearyl
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- YWKJNRNSJKEFMK-PQFQYKRASA-N (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(5,6,7,8-tetrahydroquinolin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical compound N([C@@H]1C(N2C(=C(C[N+]=3C=4CCCCC=4C=CC=3)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 YWKJNRNSJKEFMK-PQFQYKRASA-N 0.000 title claims abstract 5
- 229950009592 cefquinome Drugs 0.000 title claims abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract 16
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract 8
- 229960003511 macrogol Drugs 0.000 claims abstract 8
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000002562 thickening agent Substances 0.000 claims abstract 3
- 241001465754 Metazoa Species 0.000 claims abstract 2
- 206010046793 Uterine inflammation Diseases 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 11
- KYOHRXSGUROPGY-OFNLCGNNSA-N (6r,7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(5,6,7,8-tetrahydroquinolin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrogen sulfate Chemical group OS(O)(=O)=O.N([C@@H]1C(N2C(=C(C[N+]=3C=4CCCCC=4C=CC=3)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 KYOHRXSGUROPGY-OFNLCGNNSA-N 0.000 claims 2
- 239000004359 castor oil Substances 0.000 claims 2
- 235000019438 castor oil Nutrition 0.000 claims 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical group CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 2
- GNWCZBXSKIIURR-UHFFFAOYSA-N (2-docosanoyloxy-3-hydroxypropyl) docosanoate Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCCCCCCCC GNWCZBXSKIIURR-UHFFFAOYSA-N 0.000 claims 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Pharmaceutical composition for intrauterine application of cefquinome in a base comprising a medium chain triglyceride, a thickener and macrogol cetostearyl ether and its use for the treatment of metritis in mammalian animals.
Claims (10)
1 An intrauterine liquid composition, characterised in that it comprises cefquinome in a base, said base comprising at least one medium chain triglyceride, a thickener and at least one macrogol cetostearyl ether.
2 The composition according to claim 1 characterised in that the cefquinome is cefquinome sulphate.
3 The composition according to claims 1 or 2 characterised in that it comprises 1.0 to 20.0 % by weight of cefquinome
4 The composition according to claims 1 to 3 characterised in that the medium chain triglyceride is selected from caprylic and capric acid and mixtures thereof.
5 The composition according to claims 1 to 4 characterised in that the thickener is selected from hydrogenated castor oil and glycerol dibehenate and mixtures thereof.
6 The composition according to claims 1 to 5, characterised in that it comprises a combination of macrogol cetostearyl ether - 12 and macrogol cetostearyl ether - 20.
7 The composition according to claims 1 to 6, characterised in that the ratio of macrogol cetostearyl ether 12 and macrogol cetostearyl ether is from 1: 10 to 10:1.
8 The composition according to claims 1 to 7, characterised in that it comprises the macrogol cetostearyl ether in an amount of 0.5 to 5.0 % by weight.
9 The composition according to any if claims 1 to 8, characterised in that it comprises 1 to 10.% by weight of cefquinome sulphate, 0.1 to 3.0 % by weight of hydrogenated castor oil and 0.5 to 3.0 % by weight of macrogol cetostearyl ether in a medium chain triglyceride.
10 The use of a pharmaceutical composition according to claims 1 to 9 for the manufacture of a medicament for the treatment of metritis in mammalian animals.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84138706P | 2006-08-30 | 2006-08-30 | |
| EP06119765.3 | 2006-08-30 | ||
| EP06119765 | 2006-08-30 | ||
| US60/841,387 | 2006-08-30 | ||
| PCT/EP2007/058933 WO2008025773A1 (en) | 2006-08-30 | 2007-08-28 | Pharmaceutical compositions comprising cefquinome |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2661099A1 true CA2661099A1 (en) | 2008-03-06 |
| CA2661099C CA2661099C (en) | 2012-01-24 |
Family
ID=38515712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2661099A Expired - Fee Related CA2661099C (en) | 2006-08-30 | 2007-08-28 | Pharmaceutical compositions comprising cefquinome |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2059231A1 (en) |
| AU (1) | AU2007291308A1 (en) |
| CA (1) | CA2661099C (en) |
| WO (1) | WO2008025773A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009012423A1 (en) * | 2009-03-10 | 2010-09-16 | Bayer Animal Health Gmbh | Preparation based on oil |
| CN113952298B (en) * | 2021-12-08 | 2023-02-17 | 江苏农牧科技职业学院 | Cefquinome sulfate nano suspension and preparation method thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69717988T2 (en) * | 1996-05-10 | 2003-07-24 | Upjohn Co | TOPICAL ADMINISTRATION OF PREMAFLOXACIN FOR TREATING SYSTEMIC BACTERIAL DISEASES |
| WO2003063877A1 (en) * | 2002-02-01 | 2003-08-07 | Akzo Nobel N.V. | Cefquinome composition for intra-mammary administration in cattle |
| PL208585B1 (en) * | 2002-10-25 | 2011-05-31 | Intervet Int Bv | Prolonged release pharmaceutical composition |
| US6911441B2 (en) * | 2002-12-16 | 2005-06-28 | Akzo Nobel N.V. | Prolonged release pharmaceutical composition |
| ES2300634T3 (en) * | 2002-12-16 | 2008-06-16 | Intervet International Bv | TREATMENT OF MASTITIS WITH A COMBINATION OF PREDNISOLONE WITH CEPHALOSPORINE. |
| US7842791B2 (en) * | 2002-12-19 | 2010-11-30 | Nancy Jean Britten | Dispersible pharmaceutical compositions |
-
2007
- 2007-08-28 CA CA2661099A patent/CA2661099C/en not_active Expired - Fee Related
- 2007-08-28 AU AU2007291308A patent/AU2007291308A1/en not_active Abandoned
- 2007-08-28 EP EP07802951A patent/EP2059231A1/en not_active Withdrawn
- 2007-08-28 WO PCT/EP2007/058933 patent/WO2008025773A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| CA2661099C (en) | 2012-01-24 |
| EP2059231A1 (en) | 2009-05-20 |
| WO2008025773A1 (en) | 2008-03-06 |
| AU2007291308A1 (en) | 2008-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20130828 |