CA2657936A1 - Antiviral protease inhibitors - Google Patents

Antiviral protease inhibitors Download PDF

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Publication number
CA2657936A1
CA2657936A1 CA002657936A CA2657936A CA2657936A1 CA 2657936 A1 CA2657936 A1 CA 2657936A1 CA 002657936 A CA002657936 A CA 002657936A CA 2657936 A CA2657936 A CA 2657936A CA 2657936 A1 CA2657936 A1 CA 2657936A1
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alkyl
substituted
aryl
heterocyclyl
group
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CA2657936C (en
Inventor
Carina E. Cannizzaro
Zheng-Yu Yang
Manoj C. Desai
Michael L. Mitchell
Lianhong Xu
Sundaramoorthi Swaminathan
James M. Chen
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Gilead Sciences Inc
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Gilead Sciences, Inc.
Carina E. Cannizzaro
Zheng-Yu Yang
Manoj C. Desai
Michael L. Mitchell
Lianhong Xu
Sundaramoorthi Swaminathan
James M. Chen
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

The invention is related to compounds of Formula I or a pharmaceutically acceptable salt, solvate, ester, and /or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Description

DEMANDE OU BREVET VOLUMINEUX

LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVET COMPREND
PLUS D'UN TOME.

NOTE : Pour les tomes additionels, veuillez contacter le Bureau canadien des brevets JUMBO APPLICATIONS/PATENTS

THIS SECTION OF THE APPLICATION/PATENT CONTAINS MORE THAN ONE
VOLUME

NOTE: For additional volumes, please contact the Canadian Patent Office NOM DU FICHIER / FILE NAME:

NOTE POUR LE TOME / VOLUME NOTE:

ANTIVIRAL PROTEASE INHIBITORS
FIELD OF THE INVENTION
This invention relates to novel HIV protease inhibitors, pharmaceutical compositions thereof, processes for making the novel HIV protease inhibitors, and methods for inhibiting and treating an HIV infection.
BACKGROUND. OF THE INVENTION
In recent years, inhibitors of HIV protease have become an important class of therapeutic agents for inhibition and treatment of HIV infection in humans. HIV protease inhibitors are especially effective when administered in combination with other classes of HIV therapeutic agents, especially inhibitors of HIV reverse transcriptase, e.g. in "cocktails" of two or more HIV therapeutic agents.
On-going treatment of HIV-infected individuals with compounds that inhibit HIV protease has led to the development of mutant viruses that possess .25 proteases that are resistant to the inhibitory effect of approved, commercially available HIV therapeutic agents currently in clinical use. Thus, to be effective, new HIV protease inhibitors must be effective not only against wild-type strains of HIV, but must also demonstrate efficacy against the newly emerging mutant strains that are resistant to the commercially available protease inhibitors.
Accordingly, there continues to be a need for new HIV protease inhibitors, for example those targeting the HIV protease in both wild type and mutant strains of HIV.

SUMMARY OF THE INVENTION
Accordingly, in one embodiment, the present application provides novel HIV protease inhibitor compounds of Formula (I):

(LZ-Ar2)p ~ Arl i R2 OR3 it Ri N N11%. ~X

~ \(R6)R
YYy 0 L3 R4 Rs `Ar3 (L4-Ar4)q Formula I
or a pharmaceutically acceptable salt, solvate, and/or ester thereof, wherein, X is H, alkyl, substituted alkyl, -C(O)-, -S(O)2 , or -S(O)-;
n is 0 when X is H, alkyl, or substituted alkyl;
n is 1 when X is -C(O)-, -S(O)2 , or -S(O)-;

L' and L3 are alkylene;
LZ and L4 are independently selected from the group consisting of a covalent bond, -0-, -NH-, -0-alkylene-, and alkylene;
Ar', Ar2, Ar3, and Ar' are independently: aryl, substitt4wd aryl, heteroaryl, or substituted heteroaryl, wherein said substituted aryl or said substituted heteroaryl of Ar', ArZ, Ar3 and Ar4 is independently substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, haloalkyl, halo, nitro, cyano, hydroxy, amino, alkoxy, haloalkoxy, -NH-alkyl, -NH-(alkyl)2, -NH-acyl, -N(alkyl)-acyl, -NR -S(O)Z-Rb, -C(O)-R`, -S(O)ZRb, -S(O)ZNHRa, -C(O)-NH-R , -NReC(O)ORb, -NRaS(O)ZNR Rb, -C(O)OR', and -Z'-alkylene-R';
R' is H, alkyl, or substituted alkyl;
Rb is alkyl, aryl, or substituted aryl;
R' is aryl, heterocyclyl, substituted aryl, substituted heterocyclyl, -ZZ-L5-0, or -O-PO3R'`R7d;

LS is -C(O)-, -C(O)O-, -C(O)NR'e-, -S(O)-, -S(O)-, -S(OZ)NR'e-, or -S(O)NR'e-;
Z' and Z2 are independently 0 or NR'a;
R'a, R'`, R'd, and RW' are independently H, alkyl, or substituted alkyl;
R' is alkyl, substituted alkyl, heterocyclyl, or substituted heterocyclyl;
p and q are independently 0 or 1;
R' is -NR'eR'b, -OR', -C(R'dR'`)-NR"-L6-R'g, aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
R'a is H, alkyl, or substituted alkyl;
R'b and R" are independently selected from alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, arylalkyl, substituted arylalkyl, heterocyclyl alkyl, and substituted heterocyclyl alkyl, wherein said substituted arylalkyl is substituted on the aryl moiety and said substituted heterocyclyl alkyl is substituted on the heterocyclyl moiety;
R'd and R'e are independently selected from the group consisting of H, alkyl, and substituted alkyl; or R'd and R'e taken together with the carbon atom to which they are attached form a cycloalkyl, a substituted cycloalkyl, a non-aromatic heterocyclyl, or a substituted non-aromatic heterocyclyl;
L6 is -C(O)-, -C(O)-O-, or -C(O)-NR"'-, -S(O)Z , -S(O)Z O-, -S(O)Z-NR"'-, -S(O)-, . -S(O)-0-, or -S(O)-NR" _;
R" and R"' are independently H, alkyl, or substituted alkyl;
R'g is alkyl or substituted alkyl;
RZ, R4, and R5 are each independently selected from the group consisting of H, alkyl, and substituted alkyl;
R3is selected from the group consisting of H, -CH2 OC(O)-R3a, -CHZ-OC(O)O-R3o, -CHZ-O-PO; Z, -PO; 2, and -PO3CH,CF~';
R', is H, alkyl, or substituted alkyl;
R6 is selected from the group consisting of -0R6a, -NRbR6` ,-C(R6dR6`)R6f, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, and substituted heterocyclyl;
R' and e are independently selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, arylalkyl, substituted arylalkyl, heterocyclyl alkyl, substituted heterocyclyl alkyl, wherein said substituted arylalkyl is substituted on the aryl moiety and said substituted heterocyclyl alkyl is substituted on the heterocyclyl moiety;
is H, alkyl, or substituted alkyl;
R`d and R" are independently selected from the group consisting of H, alkyl, and substituted alkyl; or R6d and R6` taken together with the carbon atom to which they are attached form a cycloalkyl, a substituted cycloalkyl, a non-aromatic heterocyclyl, or a substituted non-aromatic heterocyclyl;
R6` is selected from the group consisting of heterocyclyl, substituted heterocyclyl, -Z3-aryl, -Z3-(substituted aryl), -Z3-heteroaryl, -Z3-(substituted heteroaryl), -Z3-L7 -R612, and -Z3-LB-R6";
Z3 is 0 or NR6f;
,L' is selected from the group consisting of -C(O)-, -C(O)-O-, and -C(O)-NRW"-;
LB is selected from the group consisting of -S(OZ)- or -S(O)-, -S(O) -0-, and -S(O)-0-;
R6f is H, alkyl, or substituted alkyl;
R6f2 is alkyl, substituted alkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, wherein said substituted arylalkyl is substituted on the aryl moiety and said substituted heteroarylalkyl is substituted on the heteroaryl moiety; and R6F' is alkyl, substituted alkyl, -0-alkyl, -O-(substituted alkyl), -NH-alkyl, -N(alkyl)õ -NH-(substituted alkyl), or -N(substituted alkyl)Z; and with the following provisos:
(1) when X is -C(O)- and n is 1, then R' and R6 are not both -CH(R~-NH-C(O)-O-Rd, wherein R` is -C(CH)3, -CH(CH)21 or -CH(CH)CHZCH3 and Rd is -CH3 or -CHZCH,;
(2) when p and q are both 0, then Ar' and Ar3 are not both phenyl or both fluorophenyl;
(3) when p and q are both 0; and Ar3 is phenyl; then Ar' is not fluorophenyl, cyanophenyl, methoxyphenyl, hydroxyphenyl, tolyl, trifluoromethylphenyl, trimethoxyphenyl, or thienyl; and (4) when p and q are both 0; Ar3 is phenyl; and R' is OR'`; then R" is not aryl methylene or heterocyclyl methylene.
In another embodiment, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of Formula I or pharmaceutically acceptable salt, solvate, and/or ester thereof.
In another embodiment, the present application provides a method for treating FIIV infections which comprises administering to a patient in need of such treatment a therapeutically effective amount of at least one compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof.
In another embodiment, the present application provides a method for treating HIV infections which comprises administering to a patient in need of such treatment a therapeutically effective combination of (a) one or more compounds of Formula I and (b) another therapeutic agent (e.g., one or more compounds selected from HIV reverse transcriptase inhibitors and HIV protease inhibitors).
In another embodiment, the present invention provides a method of treating HIV infection which comprises administering to a patient in need thereof a therapeutically effective amount of: (a) a compound of Formula (I);
and, (b) at least one cornpound selected from the group consisting of HIV
protease inhibiting compounds, HIV non-nucleoside inhibitors of reverse transcriptase, HIV nucleoside inhibitors of reverse transcriptase, HIV
nucleotide inhibitors of reverse transcriptase, HIV integrase inhibitors, non-nucleoside inhibitors of HCV, and CCR5 inhibitors.
In another embodiment, the present invention provides a kit or container comprising a compound of Formula (I) in an amount effective for use as a standard or reagent in a test or assay for determining the ability of a potential pharmaceutical compound to inhibit HIV protease and/or HIV growth.
DETAILED DESCRIPTION
Reference will now be made in detail to certain claims of the invention, examples of which are illustrated in the accompanying structures and formulas.
While the invention will be described in conjunction with the enumerated claims, it will be understood that they are not intended the invention to those claims. On the contrary, the invention is intended to cover all alternatives, modifications, and equivalents, which may be included within the scope of the present invention as defined by the claims.
DEFINITIONS
Unless stated otherwise, the following terms and phrases as used herein are intended to have the following meanings:
When trade names are used herein, applicants intend to independently include the tradename product and the active pharmaceutical ingredient(s) of the tradename product.
As used herein, "a compound of the invention" or "a compound of formula (I)" means a compound of formula (I) or a pharmaceutically acceptable salt, solvate, or physiologically functional derivative thereof. Similarly, with respect to isolatable intermediates such as for example, compounds of formula (IX), the phrase "a compound of formula (number)" means a compound of that formula and pharmaceutically acceptable salts, solvates and physiologically functional derivatives thereof.
"Alkyl" is hydrocarbon containing normal, secondary, tertiary or cyclic carbon atoms. For example, an alkyl group can have 1 to 20 carbon atoms (i.e, C,-Cm alkyl), 1 to 10 carbon atoms (i.e., C,-C,o alkyl), or 1 to 6 carbon atoms (i.e., C,-C6 alkyl). Examples of suitable alkyl groups include, but are not limited to, methyl (Me, -CH), ethyl (Et, -CH2CH),1-propyl (n-Pr, n-propyl, -CHZCHZCHj, 2-propyl (i-Pr, i-propyl, -CH(CH3)2),1-butyl (n-Bu, n-butyl, -CHCHZCHZCH), 2-methyl-l-propyl (i-Bu, i-butyl, -CHZCH(CH3)2), 2-butyl (s-Bu, s-butyl, -CH(CH,)CH2CH,), 2-methyl-2-propyl (t-Bu, t-butyl, -C(CH3)),1-pentyl (n-pentyl, -CH4CHZCH4CH2CH3), 2-pentyl (-CH(CH,)CH4CH2CH3), 3-pentyl (-CH(CH2CH3)Z), 2-methyl-2-butyl (-C(CH3)ZCHZCH3), 3-methyl-2-butyl (-CH(CH3)CH(CH3)1.), 3-methyl-l-butyl (-CHZCHZCH(CH3)2), 2-methyl-l-butyl (-CHZCH(CH)CHZCH), 1-hexyl (-CH2CHZCHZCH2CHzCH3), 2-hexyl (-CH(CH3)CHZCHZCH2CH3), 3-hexyl (-CH(CHZCH3)(CHZCHZCH)), 2-methyl-2-pentyl (-C(CH3)ZCHZCHZCH), 3-methyl-2-pentyl (-CH(CH3)CH(CH3)CHZCH,), 4-methyl-2-pentyl (-CH(CH,)CHZCH(CH3)2), 3-methyl-3-pentyl (-C(CH3)(CH2CH3)z), 2-methyl-3-pentyl (-CH(CHZCH3)CH(CH3)2), 2,3-dimethyl-2-butyl (-C(CH,)ZCH(CH,)Z), 3,3-dimethyl-2-butyl (-CH(CH)C(CH). and octyl (-(CHZ),CH,), "Alkoxy" means a group having the formula -0-alkyl, in which an alkyl group, as defined above, is attached to the parent molecule via an oxygen atom.
The alkyl portion of an alkoxy group can have 1 to 20 carbon atoms (i.e., C1-C,,, alkoxy), 1 to 12 carbon atoms(i.e., C1-C12 alkoxy), or 1 to 6 carbon atoms(i.e., C1-C6 alkoxy). Examples of suitable alkoxy groups include, but are not limited to, methoxy (-O-CH3 or -OMe), ethoxy (-OCHZCH3 or -OEt), t-butoxy (-O-C(CH3)3 or -OtBu) and the like.
"Haloalkyl" is an alkyl group, as defined above, in which one or more hydrogen atoms of the alkyl group is replaced with a halogen atom. The alkyl portion of a haloalkyl group can have 1 to 20 carbon atoms (i.e., C1-C,.
haloalkyl), 1 to 12 carbon atoms(i.e., C,-C,Z haloalkyl), or 1 to 6 carbon atoms(i.e., C1-C6 alkyl).
Examples of suitable haloalkyl groups include, but are not limited to, -CF3, -CHFZ, -CFHZ, -CH2CF3, and the like.
"Alkenyl" is a hydrocarbon containing normal, secondary, tertiary or cyclic carbon atoms with at least one site of unsaturation, i.e. a carbon-carbon, sp2 double bond. For example, an alkenyl group can have 2 to 20 carbon atoms (i.e., CZ C,,alkenyl), 2 to 12 carbon atoms (i.e., CZ C12 alkenyl), or 2 to 6 carbon atoms (i.e., CZ C6 alkenyl). Examples of suitable alkenyl groups include, but are not limited to, ethylene or vinyl (-CH=Q.H2), allyl (-CH2CH=CH2), cyclopentenyl (-CSH,), and 5-hexenyl (-CHZCH2CHZCH4CH=CHZ).
"Alkynyl" is a hydrocarbon containing normal, secondary, tertiary or cyclic carbon atoms with at least one site of unsaturation, i.e. a carbon-carbon, sp triple bond. For example, an alkynyl group can have 2 to 20 carbon atoms (i.e., CZ C2Oalkynyl), 2 to 12 carbon atoms (i.e., CZ C,Z alkyne,), or 2 to 6 carbon atoms (i.e., CZ-C6 alkynyl). Examples of suitable alkynyl groups include, but are not limited to, acetylenic (-C=CH), propargyl (-CHZC=_CH), and the like.
"Alkylene" refers to a saturated, branched or straight chain or cyclic hydrocarbon radical having two monovalent radical centers derived by the removal of two hydrogen atoms from the same or two different carbon atoms of a parent alkane. For example, an alkylene group can have 1 to 20 carbon atoms, 1 to 10 carbon atoms, or 1 to 6 carbon atoms. Typical alkylene radicals include, but are not limited to, methylene (-CHZ-),1,1-ethyl (-CH(CH3)-),1,2=ethyl (-CHZCHZ-),1,1-propyl (-CH(CH4CHO-),1,2-propyl (-CHZCH(CH3)-),1,3-propyl (-CHzCHZCH2-), 1,4-butyl (-CH2CHCHZCH2-), and the like. -"Alkenylene" refers to an unsaturated, branched or straight chain or cyclic hydrocarbon radical having two monovalent radical centers derived by the removal of two hydrogen atoms from the same or two different carbon atoms of a parent alkene. For example, and alkenylene group can have 1 to 20 carbon atoms, 1 to 10 carbon atoms, or 1 to 6 carbon atoms. Typical alkenylene radicals include, but are not limited to, 1,2-ethylene (-CH=CH-).
"Alkynylene" refers to an unsaturated, branched or straight chain or cyclic hydrocarbon radical having two monovalent radical centers derived by the removal of two hydrogen atoms from the same or two different carbon atoms of a parent alkyne. For example, an alkynylene group can have 1 to 20 carbon atoms,l to 10 carbon atoms, or 1 to 6 carbon atoms. Typical alkynylene radicals include, but are not limited to, acetylene (-C=-C-), propargyl (-CHZC=--C-), and 4-pentynyl (-CH2CHZCHZC=-CH-).
"Aryl" means an aromatic hydrocarbon radical derived by the removal of one hydrogen atom from a single carbon atom of a parent aromatic ring system.
For example, an aryl group can have 6 to 20 carbon atoms, 6 to 14 carbon atoms, or 6 to 12 carbon atoms. Typical aryl groups include, but are not limited to, radicals derived from benzene (e.g., phenyl), substituted benzene, naphthalene, anthracene, biphenyl, and the like.
"Arylalkyl" refers to an acyclic alkyl radical in which one of the hydrogen atoms bonded to a carbon atom, typically a terminal or sp3 carbon atom, is replaced with an aryl radical. Typical arylalkyl groups include, but are not limited to, benzyl, 2-phenylethan-1-yl, naphthylmethyl, 2-naphthylethan-1-yl, naphthobenzyl, 2-naphthophenylethan-1-yl and the like. The arylalkyl group can comprise 6 to 20 carbon atoms, e.g., the alkyl moiety is 1 to 6 carbon atoms and the aryl moiety is 6 to 14 carbon atoms.
"Arylalkenyl" refers to an acyclic alkenyl radical in which one of the hydrogen atoms bonded to a carbon atom, typically a terminal or sp3 carbon atom, but also an spZ carbon atom, is replaced with an aryl radical. The aryl portion of the arylalkenyl can include, for example, any of the aryl groups disclosed herein, and the alkenyl portion of the arylalkenyl can include, for example, any of the alkenyl groups disclosed herein. The arylalkenyl group can comprise 6 to 20 carbon atoms, e.g., the alkenyl moiety is 1 to 6 carbon atoms and the aryl moiety is 6 to 14 carbon atoms.
"Arylalkynyl" refers to an acyclic alkynyl radical in which one of the hydrogen atoms bonded to a carbon atom, typically a terminal or sp3 carbon atom, but also an sp carbon atom, is replaced with an aryl radical. The aryl portion of the arylalkynyl can include, for example, any of the aryl groups disclosed herein, and the alkynyl portion of the arylalkynyl can include, for example, any of the alkynyl groups disclosed herein. The arylalkynyl group can comprise 6 to 20 carbon atoms, e.g., the alkynyl moiety is 1 to 6 carbon atoms and the aryl moiety is 6 to 14 carbon atoms.
The term "substituted" in reference to alkyl, alkylene, aryl, arylalkyl, heterocyclyl, etc. , for example, "substituted alkyl", "substituted alkylene", "substituted aryl", "substituted arylalkyl", "substituted heterocyclyl", and "substituted carbocyclyl" means alkyl, alkylene, aryl, arylalkyl, heterocyclyl, carbocyclyl respectively, in which one or more hydrogen atoms are each independently replaced with a non-hydrogen substituent. Typical substituents include, but are not limited to, -X, -R, -O-, =0, -OR, -SR, -S-, -NR2, -NR,, =NR, -CX,, -CN, -OCN, -SCN, -N=C=O, -NCS, -NO, -NOZ, =N2, -N,, NC(=O)R, -C(=O)R, -C(=O)NRR -S(=O)ZO-, -S(=O)ZOH, -S(=O)ZR, -OS(=O)ZOR, -S(=O)ZNR, -S(=O)R, -OP(=O)OZRR,-P(=O)OZRR -P(=O)(O")2, -P(=O)(OH)Z, -C(=O)R, -C(=O)X, -C(S)R, -C(O)OR, -C(O)O", -C(S)OR, -C(O)SR, -C(S)SR, -C(O)NRR, -C(S)NRR, -C(NR)NRR, where each X is independently a halogen: F, Cl, Br, or I; and each R
is independently H, alkyl, aryl, arylalkyl, a heterocycle, or a protecting group or prodrug moiety. Alkylene, alkenylene, and alkynylene groups may also be similarly substituted.
"Bioavailability" is the degree to which the pharmaceutically active agent becomes available to the target tissue after the agent's introduction into the body. Enhancement of the bioavailability of a pharmaceutically active agent can provide a more efficient and effective treatment for patients because, for a given dose, more of the pharmaceutically active agent will be available at the targeted tissue sites.
"Heteroalkyl" refers to an alkyl group where one or more carbon atoms have been replaced. with a heteroatom, such as, 0, N, or S. For example, if the carbon atom of the alkyl group which is attached to the parent molecule is replaced with a heteroatom (e.g., 0, N, or S) the resulting heteroalkyl groups are, respectively, an alkoxy group (e.g., -OCH3, etc.), an amine (e.g., -NHCH3, -N(CH)Z, etc.), or a thioallcyl group (e.g., -SCH3). If a non-terminal carbon atom of the alkyl group which is not attached to the parent molecule is replaced with a heteroatom (e.g., 0, N, or S) and the resulting heteroalkyl groups are, respectively, an alkyl ether (e.g., -CH2CH2-O-CH3, etc.), an alkyl amine (e.g., -CHZNHCH,, -CHZN(CH;)2, etc.), or a thioalkyl ether (e.g., CHZ-S-CH). If a terminal carbon atom of'the alkyl group is replaced with a heteroatom (e.g., 0, N, or S), the resulting heteroalkyl groups are, respectively, a hydroxyalkyl group (e.g., -CHZCHZ-OH), an aminoalkyl group (e.g., -CHZNH), or an alkyl thiol group (e.g., -CHZCHZ-SH). A
heteroalkyl group can have, for example,l to 20 carbon atoms,l to 10 carbon atoms, or 1 to carbon atoms. A C,-C6 heteroalkyl group means a heteroalkyl group having 1 to carbon atoms.
"Heterocycle" or "heterocyclyl" as used herein includes by way of example and not limitation those heterocycles described in Paquette, Leo A.;
Principles of Modern Heterocyclic Chemistry (W.A. Benjamin, New York, 1968), particularly Chapters 1, 3, 4, 6, 7, and 9; The Chemistry of Heterocyclic Compounds, A Series of Monographs" (John Wiley & Sons, New York, 1950 to present), in particular Volumes 13, 14, 16, 19, and 28; and J. Am. Chem. Soc.
(1960) 82:5566. In one specific embodiment of the invention "heterocycle" includes a "carbocycle" as defined herein, wherein one or more (e.g. 1, 2, 3, or 4) carbon atoms have been replaced with a heteroatom (e.g. 0, N, or S). The terms "heterocycle" or "heterocyclyl" includes saturated rings, partially unsaturated rings, and aromatic rings (i.e., heteroaromatic rings). Substituted heterocyclyls include, for example, heterocyclic rings substituted with any of the substituents disclosed herein including carbonyl groups. A non-limiting example of a.
carbonyl substituted heterocyclyl is:

~Nr-I
NH

Examples of heterocycles include by way of example and not limitation pyridyl, dihydroypyridyl, tetrahydropyridyl (piperidyl), thiazolyl, tetrahydrothiophenyl, sulfur oxidized tetrahydrothiophenyl, pyrimidinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, thianaphthalenyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, 4-piperidonyl, pyrrolidinyl, 2-pyrrolidonyl, pyrrolinyl, tetrahydrofuranyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, decahydroquinolinyl, octahydroisoquinolinyl, azocinyl, triazinyl, 6H-1,2,5-thiadiazinyl, 2H,6H-1,5,2-dithiazinyl, thienyl, thianthrenyl, pyranyl, -5 isobenzofuranyl, chromenyl, xanthenyl, phenoxathinyl, 2H-pyrrolyl, isothiazolyl, isoxazolyl, pyrazinyl, pyridazinyl, indolizinyl, isoindolyl, 3H-indolyl, 1H-indazoly, purinyl, 4H-quinolizinyl, phthalazinyl, naphthyridinyl, quinoxalinyl, quinazolinyl, cinnolinyl, pteridinyl, 4aH-carbazolyl, carbazolyl, ~i-carbolinyl, phenanthridinyl, acridinyl, pyrimidinyl, phenanthrolinyl, phenazinyl, phenothiazinyl, furazanyl, phenoxazinyl, isochromanyl, chromanyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyrazolinyl, piperazinyl, indolinyl, isoindolinyl, quinuclidinyl, morpholinyl, oxazolidinyl, benzotriazolyl, benzisoxazolyl, oxindolyl, benzoxazolinyl, isatinoyl, and bis-tetrahydrofuranyl:

O
=,, O"/
By way of example and not limitation, carbon bonded heterocycles are bonded at position 2, 3, 4, 5, or 6 of a pyridine, position 3, 4, 5, or 6 of a pyridazine, position 2, 4, 5, or 6 of a pyrimidine, position 2, 3, 5, or 6 of a pyrazine, position 2, 3, 4, or 5 of a furan, tetrahydrofuran, thiofuran, thiophene, pyrrole or tetrahydropyrrole, position 2, 4, or 5 of an oxazole, imidazole or thiazole, position 3,4, or 5 of an isoxazole, pyrazole, or isothiazole, position 2 or 3 of an aziridine, position 2, 3, or 4 of an azetidine, position 2, 3, 4, 5, 6, 7, or 8 of a quinoline or position 1, 3, 4, 5, 6, 7, or 8 of an isoquinoline. Still more typically, carbon bonded heterocycles include 2-pyridyl, 3-pyridyl, 4-pyridyl, 5-pyridyl, pyridyl, 3-pyridazinyl, 4-pyridazinyl, 5-pyridazinyl, 6-pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 6-pyrimidinyl, 2-pyrazinyl, 3-pyrazinyl, 5-pyrazinyl; 6-pyrazinyl, 2-thiazolyl, 4-thiazolyl, or 5-thiazolyl.
By way of example and not limitation, nitrogen bonded heterocycles are bonded at position 1 of an aziridine, azetidine, pyrrole, pyrrolidine, 2-pyrroline, 3-pyrroline, imidazole, imidazolidine, 2-imidazoline, 3-imidazoline, pyrazole, pyrazoline, 2-pyrazoline, 3-pyrazoline, piperidine, piperazine, indole, indoline, 1H-indazole, position 2 of a isoindole, or isoindoline, position 4 of a morpholine, and position 9 of a carbazole, or P-carboline. Still more typically, nitrogen bonded heterocycles include 1-aziridyl, 1-azetedyl, 1-pyrrolyl, 1-imidazolyl, pyrazolyl, and 1-piperidinyl.
"Heterocyclylalkyl" refers to an acyclic alkyl radical in which one of the hydrogen atoms bonded to a carbon atom, typically a terminal or sp3 carbon atom, is replaced with a heterocyclyl radical (i.e., a heterocyclyl-alkylene-moiety). Typical heterocyclyl alkyl groups include, but are not limited to heterocyclyl-CHZ-, 2-(heterocyclyl)ethan-1-yl, and the like, wherein the "heterocyclyl" portion includes any of the heterocyclyl groups described above, including those described in Principles of Modern Heteroc,yclic Chemistry. One skilled in the art will also understand that the heterocyclyl group can be attached to the alkyl portion of the heterocyclyl alkyl by means of a carbon-carbon bond or a carbon-heteroatom bond, with the proviso that the resulting group is chemically stable. The heterocyclyl alkyl group comprises 6 to 20 carbon atoms, e.g., the alkyl portion of the arylalkyl group is 1 to 6 carbon atoms and the heterocyclyl moiety is 5 to 14 carbon atoms. Examples of heterocyclylalkyls include by way of example and not limitation 5-membered sulfur, oxygen, and/or nitrogen containing heterocycles such as thiazolylmethyl, 2-thiazolylethan-1-y1, imidazolylmethyl, oxazolylmethyl, thiadiazolylmethyl, etc., 6-membered sulfur, oxygen, and/or nitrogen containing heterocycles such as piperidinylmethyl, piperazinylmethyl, morpholinylmethyl, pyridinylmethyl, pyridizylmethyl, pyrimidylmethyl, pyrazinylmethyl, etc.
"Heterocyclylalkenyl" refers to an acyclic alkenyl radical in which one of the hydrogen atoms bonded to a carbon atom, typically a terminal or sp3 carbon atom, but also a sp2 carbon atom, is replaced with a heterocyclyl radical (i.e., a heterocyclyl-alkenylene- moiety). The heterocyclyl portion of the heterocyclyl alkenyl group includes any of the heterocyclyl groups described herein, including those described in Principles of Modern Heterocyclic Chemistry, and the alkenyl portion of the heterocyclyl alkenyl group includes any of the alkenyl groups disclosed herein. One skilled in the art will also understand that the heterocyclyl group can be attached to the alkenyl portion of the heterocyclyl alkenyl by means of a carbon-carbon bond or a carbon-heteroatom bond, with the proviso that the resulting group is chemically stable. The heterocyclyl alkenyl group comprises 6 to 20 carbon atoms, e.g., the alkenyl portion of the heterocyclyl alkenyl group is 1 to 6 carbon atoms and the heterocyclyl moiety is 5 to 14 carbon atoms.
"Heterocyclylalkynyl" refers to an acyclic alkynyl radical in which one of the hydrogen atoms bonded to a carbon atom, typically a terminal or sp3 carbon atom, but also an sp carbon atom, is replaced with a heterocyclyl radical (i.e., a heterocyclyl-alkynylene- moiety). The heterocyclyl portion of the heterocyclyl alkynyl group includes any of the heterocyclyl groups described herein, including those described in Principles of Modern Heteroc,yclic Chemistrv, and the alkynyl portion of the heterocyclyl alkynyl group includes any of the alkynyl groups disclosed herein. One skilled in the art will also understand that the heterocyclyl group can be attached to the alkynyl portion of the heterocyclyl alkynyl by means of a carbon-carbon bond or a carbon-heteroatom bond, with the proviso that the resulting group is chemically stable. The heterocyclyl alkynyl group comprises 6 to 20 carbon atoms, e.g., the alkynyl portion of the heterocyclyl alkynyl group is 1 to 6 carbon atoms and the heterocyclyl moiety is 5 to 14 carbon atoms.
"Heteroaryl" refers to an aromatic heterocyclyl having at least one heteroatom in the ring. Non-limiting examples of suitable heteroatoms which can be included in the aromatic ring include oxygen, sulfur, and nitrogen. Non-limiting examples of heteroaryl rings include all of those listed in the definition of "heterocyclyl", including pyridinyl, pyrrolyl, oxazolyl, indolyl, isoindolyl, purinyl, furanyl, thienyl, benzofuranyl, benzothiophenyl, carbazolyl, imidazolyl, thiazolyl, isoxazolyl, pyrazolyl, isothiazolyl, quinolyl, isoquinolyl, pyridazyl, pyrimidyl, pyrazyl, etc.
"Carbocycle" or "carbocyclyl" refers to a saturated, partially unsaturated or aromatic ring having 3 to 7 carbon atoms as a monocycle, 7 to 12 carbon atoms as a bicycle, and up to about 20 carbon atoms as a polycycle. Monocyclic carbocycles have 3 to 6 ring atoms, still more typically 5 or 6 ring atoms.
Bicyclic carbocycles have 7 to 12 ring atoms, e.g., arranged as a bicyclo [4,5], [5,5], [5,6] or [6,6] system, or .9 or 10 ring atoms arranged as a bicyclo [5,6] or [6,6]
system.
Examples of monocyclic carbocycles include cyclopropyl, cyclobutyl, cyclopentyl, 1-cyclopent-l-enyl, 1-cyclopent-2-enyl, 1-cyclopent-3-enyl, cyclohexyl, 1-cyclohex-l-enyl,1-cyclohex-2-enyl, 1-cyclohex-3-enyl, phenyl, and naphthyl.
"Arylheteroalkyl" refers to a heteroalkyl as defined herein, in which a hydrogen atom (which may be attached either to a carbon atom or a heteroatom) has been replaced with an aryl group as defined herein. The aryl groups may be bonded to a carboin atom of the heteroalkyl group, or to a heteroatom of the heteroalkyl group, provided that the resulting arylheteroalkyl group provides a chemically stable moiety. For example, an arylheteroalkyl group can have the general formulae -alkylene-O-aryl, -alkylene-O-alkylene-aryl, -alkylene-NH-aryl, -alkylene-NH-alkylene-aryl, -alkylene-S-aryl, -alkylene-S-alkylene-aryl, etc.
In addition, any of the alkylene moieties in the general formulae above can be further substituted with any of the substituents defined or exemplified herein.
"Heteroarylalkyl" refers to an alkyl group, as defined herein, in which a hydrogen atom has been replaced with a heteToaryl group as defined herein.
Non-limiting examples of heteroarylalkyl include -CHZ pyridinyl, -CHZ
pyrrolyl, -CHZ-oxazolyl, -CH2-indolyl, -CHZ isoindolyl, -CH2-purinyl, -CH2-furanyl, -CH2-thienyl, -CH2-benzofuranyl, -CHZ-benzothiophenyl, -CHZ carbazolyl, -CHZ imidazolyl, -CHZ thiazolyl, -CH2-isoxazolyl, -CHZ pyrazolyl, -CH2-isothiazolyl, -CHZ-quinolyl, -CHZ-isoquinolyl, -CH2-pyridazyl, -CHZ pyrimidyl, -CHZ-pyrazyl, -CH(CH)-pyridinyl, -CH(CH)-pyrrolyl, -CH(CH,)-oxazolyl, -CH(CH)-indolyl, -CH(CH3)-isoindolyl, -CH(CH)-purinyl, -CH(CH)-furanyl, -CH(CH)-thienyl, -CH(CH3)-benzofuranyl, -CH(CH3)-benzothiophenyl, -CH(CH3)-carbazolyl, -CH(CH3)-imidazolyl, -CH(CH)-thiazolyl, -CH(CH)-isoxazolyl, -CH(CH3)-pyrazolyl, -CH(CH3)-isothiazolyl, -CH(CH3)-quinolyl, -CH(CH3)-isoquinolyl, -CH(CH)-pyridazyl, -CH(CH)-pyrimidyl, -CH(CH)-pyrazyl, etc.

The term "optionally substituted" in reference to a particular moiety of the compound of Formula I (e.g., an optionally substituted aryl group) refers to a moiety having 0, 1, 2, or more substituents.
The terxn "chiral" refers to molecules which have the property of non-superimposability of the mirror image partner, while the term "achiral" refers to molecules which are superimposable on their mirror image partner.
The term "stereoisomers" refers to compounds which have identical chemical constitution, but differ with regard to the arrangement of the atoms or groups in space.
"Diastereomer" refers to a stereoisomer with two or more centers of chirality and whose molecules are not mirror images of one another.
Diastereomers have different physical properties, e.g., melting points, boiling points, spectral properties, and reactivities. Mixtures of diastereomers may separate under high resolution analytical procedures such as 'electrophoresis and chromatography.
The term "heteroaryl," as used herein, refers to an aromatic five or six-membered ring where at least one atom is selected from the group consisting of N, 0, and S, and the remaining atoms are carbon. The term "heteroaryl" also includes bicyclic systems where a heteroaryl ring is fused to a phenyl group, a monocyclic cycloalkyl group, as defined herein, a heterocycle group, as defined herein, or an additional heteroaryl group. The term "heteroaryl" also includes tricyclic systems where a bicyclic system is fused to a phenyl group, a monocyclic cycloalkyl group, as defined herein, a heterocycle group, as defined herein, or an additional heteroaryl group. The heteroaryl groups are connected to the parent molecular moiety through any substitutable carbon or nitrogen atom in the groups. Examples of heteroaryl groups include benzothienyl, benzoxazolyl, benzimidazolyl, benzoxadiazolyl, dibenzofuranyl, dihydrobenzothiazolyl, furanyl (furyl), imidazolyl, imidazopyridinyl, indazolyl, indolyl, isoindolyl, isoxazolyl, isoquinolinyl, isothiazolyl, oxadiazolyl, oxazolyl, thiazolyl, thienopyridinyl, thienyl, triazolyl, thiadiazolyl, tetrazolyl, pyridoimidazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyrazolyl, pyrrolyl, quinolinyl, tetrahydroquinolinyl, tetrahydropyranyl and triazinyl.
The heteroaryl groups of the present invention can be substituted or unsubstituted.
In addition, the nitrogen heteroatoms can be optionally quaternized or oxidized to the N-oxide. Also, the nitrogen containing rings can be optionally N-protected.
"Enantiomers" refer to two stereoisomers of a compound which are non-superimposable mirror images of one another.
Stereochemical definitions and conventions used herein generally follow S. P. Parker, Ed., McGraw-Hill Dictionary of Chemical Terms (1984) McGraw-Hill Book Company; New York; and Eliel, E. and Wilen, S., Stereochemistry of Organic Compounds (1994) John Wiley & Sons, Inc., New York. Many organic compounds exist in optically active forms, i.e., they have the ability to rotate the plane of plane-polarized light. In describing an optically active compound, the prefixes D and L or R and S are used to denote the absolute configuration of the molecule about its chiral center(s). The prefixes d and 1 or (+) and (-) are employed to designate the sign of rotation of plane-polarized light by the compound, with (-) or 1 meaning that the compound is levorotatory. A
compound prefixed with (+) or d is dextrorotatory. For a given chemical structure, these stereoisomers are identical except that they are mirror images of one another. A specific stereoisomer may also be referred to as an enantiomer, and a mixture of such isomers is often called an enantiomeric mixture. A 50:50 mixture of enantiomers is referred to as a racemic mixture or a racemate, which may occur where there has been no stereoselection or stereospecificity in a chemical reaction or process. The terms "racemic mixture" and "racemate" refer to an equimolar mixture of two enantiomeric species, devoid of optical activity.
"Linker" or "link" refers to a chemical moiety comprising a covalent bond or a chain or group of atoms that covalently attaches a phosphonate group to a drug. Linkers include portions of substituents A' and A3, which include moieties such as: repeating units of alkyloxy (e.g., polyethylenoxy, PEG, polymethyleneoxy) and alkylamino (e.g., polyethyleneamino, JeffamineTM); and diacid ester and amides including succinate, succinamide, diglycolate, malonate, and caproamide.
The terms "phosphonate" and "phosphonate group" include functional groups or moieties within a molecule that comprises a phosphorous that is 1) single-bonded to a carbon, 2) double-bonded to a heteroatom, 3) single-bonded to a heteroatom, and 4) single-bonded to another heteroatom, wherein each heteroatom can be the same or different. The terms "phosphonate" and "phosphonate group" also include functional groups or moieties that comprise a phosphorous in the saine oxidation state as the phosphorous described above, as well as functional groups or moieties that comprise a prodrug moiety that can separate from a compound so that the compound retains a phosphorous having the characteristics described above. For example, the terms "phosphonate" and "phosphonate group" include phosphonic acid, phosphonic monoester, phosphonic diester, phosphonamidate, and phosphonthioate functional groups.
In one specific embodiment of the invention, the terms "phosphonate" and "phosphonate group" include functional groups or moieties within a molecule that comprises a phosphorous that is 1) single-bonded to a carbon, 2) double-bonded to an oxygen, 3) single-bonded to an oxygen, and 4) single-bonded to another oxygen, as well as functional groups or moieties that comprise a prodrug moiety that can separate from a compound so that the compound retains a phosphorous having such characteristics. In another specific embodiment of the invention, the terms "phosphonate" and "phosphonate group" include functional groups or moieties within a molecule that comprises a phosphorous that is 1) single-bonded to a carbon, 2) double-bonded to an oxygen, 3) single-bonded to an oxygen or nitrogen, and 4) single-bonded to another oxygen or nitrogen, as well as functional groups or moieties that comprise a prodrug moiety that can separate from a compound so that_the compound retains a phosphorous having such characteristics.
The term "prodrug" as used herein refers to any compound that when administered to a biological system generates the drug substance, i.e. active ingredient, as a result of spontaneous chemical reaction(s), enzyme catalyzed chemical reaction(s), photolysis, and/or metabolic chemical reaction(s). A
prodrug is thus a covalently modified analog or latent form of a therapeutically-active compound.
"Prodrug moiety" refers to a labile functional group which separates from the active compound during metabolism, systemically, inside a cell, by hydrolysis, enzymatic cleavage, or by some other process (Bundgaard, Hans, "Design and Application of Prodrugs" in A Textbook of Drug Design and Development (1991), P. Krogsgaard-Larsen and H. Bundgaard, Eds. Harwood Academic Publishers, pp. 113-191). Enzymes which are capable of an enzymatic activation mechanism with the phosphonate prodrug compounds of the invention include, but are not limited to, amidases, esterases, microbial enzymes, phospholipases, cholinesterases, and phosphases. Prodrug moieties can serve to enhance solubility, absorption and lipophilicity to optimize drug delivery, bioavailability and efficacy. A prodrug moiety may include an active metabolite or drug itself.
Exemplary prodrug moieties include the hydrolytically sensitive or labile acyloxymethyl esters -CHZOC(=O)Ra and acyloxymethyl carbonates -CH20C(=O)OR where Re is C,-C6 alkyl, C1-C6 substituted alkyl, C6-C2,, aryl or C6 C. substituted aryl. The acyloxyalkyl ester was first used as a prodrug strategy for carboxylic acids and then applied to phosphates and phosphonates by Farquhar et al. (1983) J. Pharm. Sci. 72: 324; also US Patent Nos. 4816570, 4968788, 5663159 and 5792756. Subsequently, the acyloxyalkyl ester was used to deliver phosphonic acids across cell membranes and to enhance oral bioavailability. A close variant of the acyloxyalkyl ester, the alkoxycarbonyloxyalkyl ester (carbonate), may also enhance oral bioavailability as a prodrug moiety in the compounds of the combinations of the invention. An exemplary acyloxymethyl ester is pivaloyloxymethoxy, (POM) -CHZOC(=O)C(CH,),. An exemplary acyloxymethyl carbonate prodrug moiety is pivaloyloxymethylcarbonate (POC) -CHZOC(=O)OC(CH3)3.
The phosphonate group may be a phosphonate prodrug moiety. The prodrug moiety may be sensitive to hydrolysis, such as, but not limited to a pivaloyloxymethyl carbonate (POC) or POM group. Alternatively, the prodrug moiety may be sensitive to enzymatic potentiated cleavage, such as a lactate ester or a phosphonamidate-ester group.
One skilled in the art will recognize that substituents and other moieties of the compounds of Formula I should be selected in order to provide a compound which is sufficiently stable to provide a pharmaceutically useful compound which can be formulated into an acceptably stable pharmaceutical composition.
Compounds of Formula I which have such stability are contemplated as falling within the scope of the present invention.

Protecting Groups In the context of the present invention, protecting groups include prodrug moieties and chemical protecting groups.
Protecting groups are available, commonly known and used, and are optionally used to prevent side reactions_ with the protected group during synthetic procedures, i.e. routes or methods to prepare the compounds of the invention. For the most part the decision as to which groups to protect, when to do so, and the nature of the chemical protecting group "PG" will be dependent upon the chemistry of the reaction to be protected against (e.g., acidic, basic, oxidative, reductive or other conditions) and the intended direction of the synthesis. The PG groups do not need to be, and generally are not, the same if the compound is substituted with multiple PG. In general, PG will be used to protect functional groups such as carboxyl, hydroxyl, thio, or amino groups and to thus prevent side reactions or to otherwise facilitate the synthetic efficiency.
The order of deprotection to yield free, deprotected groups is dependent upon the intended direction of the synthesis and the reaction conditions to be encountered, and may occur in any order as determined by the artisan.
Various functional groups of the compbunds of the invention may be protected. For example, protecting groups for -OH groups (whether hydroxyl, carboxylic acid, phosphonic acid, or other functions) include "ether- or ester-forming groups". Ether- or ester-forming groups are capable of functioning as chemical protecting groups in the synthetic schemes set forth herein. However, some hydroxyl and thio protecting groups are neither ether- nor ester-forming groups, as will be understood by those skilled in the art, and are included with amides, discussed below.
A very large number of hydroxyl protecting groups and amide-forming groups and corresponding chemical cleavage reactions are described in Protective Groups in Organic Synthesis, Theodora W. Greene (John Wiley &
Sons, Inc., New York, 1991, ISBN 0-471-62301-6) ("Greene"). See also Kocienski, Philip J.; Protecting Groups (Georg Thieme Verlag Stuttgart, New York, 1994), which is incorporated by reference in its entirety herein. In particular Chapter 1, Protecting Groups: An Overview, pages 1-20, Chapter 2, Hydroxyl Protecting Groups, pages 21-94, Chapter 3, Diol Protecting Groups, pages 95-117, Chapter 4, Carboxyl Protecting Groups, pages 118-154, Chapter 5, Carbonyl Protecting Groups, pages 155-184. For protecting groups for carboxylic acid, phosphonic acid, phosphonate, sulfonic acid and other protecting groups for acids see Greene as set forth below. Such groups include by way of example and not limitation, esters, amides, hydrazides, and the like.
Ether- and Ester-forming protecting groups Ester-forming groups include: (1) phosphonate ester-forming groups, such as phosphonamidate esters, phosphorothioate esters, phosphonate esters, and phosphon-bis-amidates; (2) carboxyl ester-forming groups, and (3) sulphur ester-forming groups, such as sulphonate, sulfate, and sulfinate.

Metabolites of the Compounds of the Invention Also falling within the scope of this invention are the in vivo metabolic products of the compounds described herein. Such products may result for example from the oxidation, reduction, hydrolysis, amidation, esterification and the like of the administered compound, primarily due to enzymatic processes.
Accordingly, the invention includes compounds produced by a process comprising contacting a compound of this invention with a mammal for a period of time sufficient to yield a metabolic product thereof. Such products typically are identified by preparing a radiolabelled (e.g., C14 or H3) compound of the invention, administering it parenterally in a detectable dose (e.g., greater than about 0.5 mg/kg) to an animal such as rat, mouse, guinea pig, monkey, or to man, allowing sufficient time for metabolism to occur (typically about 30 seconds to 30 hours) and isolating its conversion products from the urine, blood or other biological samples. These products are easily isolated since they are labeled (others are isolated by the use of antibodies capable of binding epitopes surviving in the metabolite). The metabolite structures are determined in conventional fashion, e.g., by MS or NMR analysis. In general, analysis of metabolites is done in the same way as conventional drug metabolism studies well-known to those skilled in the art. The conversion products, so long as they are not otherwise found in vivo, are useful in diagnostic assays for therapeutic dosing of the compounds of the invention even if they possess no anti-infective activity of their own.

Compounds of Formula I
In one embodiment, the present application provides compounds according to Formula I, as described herein.
In another embodiment of the compounds of Formula I, X is -C(O)-, -S(OZ)-, or -S(O)-; and R3 is H, or substituted alkyl.
In another embodiment of the compounds of Formula I, X is -C(O)- or -S(OZ)-; and R3 is H.
In another embodiment of the compounds of Formula I, RZ is H.
In another embodiment of the compounds of Formula I, R' is OR'`; and R"
is alkyl, substituted alkyl, heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said substituted heterocyclyl alkyl is substituted on the heterocyclyl moiety, and said heterocyclyl is selected from the group consisting of: (i) a mono-cyclic 5- or 6-membered aromatic,.
nonaromatic dihydro, or nonaromatic tetrahydro heterocyclic ring having from 1 to 4 heteroatoms selected from N, 0, and S; and (ii) a bi-cyclic 8-, 9-, or 10-membered aromatic, nonaromatic dihydro, or nonaromatic tetrahydro heterocyclic ring having from 1 to 6 heteroatoms selected from N, 0, and S.
In another embodiment of the compounds of Formula I, R' is OR'`; and R'`
is methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, or tert-butyl.
In another embodiment of the compounds of Formula I, R' is OR'`; and R'`
is selected from the group consisting of CH2)m \(DCH2)m )b 8 ~, 8 (R8 (R )a (R8)a (R )a A', A2, A3, and A4 are independently NR9 or 0; RB is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, -O-(alkyl), or -O-(substituted alkyl); R' is H, alkyl, or substituted alkyl; m is 1 or 2; and a and b are independently 0, 1, or 2.
In another embodiment of the compounds of Formula I, R' is OR'`; and R"
is selected from the group consisting of (H2)m CH
( 2)m (CH2)m `t, /~ (R8)b `*(W) ~~'~ J
I `Z \ 8 a (R8)a (R )a A', AZ, A3, and A" are O; R 8 is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, -0-(alkyl), or -0-(substituted alkyl); m is 1; and a and b are independently 0, 1, or 2.
In another embodiment of the compounds of Formula I, R' is OR"; and R"
is heterocyclyl having one of the following structures:

(R12)r / (R12)r I1 V"-n--, D1-D2 n ~, f 2 r (R'Z)r ~i W(Rt2)r , DaDs Ds'_ Da (Ri~ (R12)r (R12)/ (R12)rr wherein D', DZ, D3, D', and DS are independently selected from the group consisting of C, N, 0, and S; n is 0 or 1; each R'Z is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R12), r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent; and ----- is a single or double bond.
In another embodiment of the compounds of Formula I, R' is Rlf XeTR19 R1d and R'e are each independently selected from the group consisting of H, alkyl, and substituted alkyl; or R1d and R'e taken together with the carbon atom to which they are shown attached form a heterocyclyl or a substituted heterocyclyl, wherein said heterocyclyl or said substituted heterocyclyl is a 5- or 6-membered non-aromatic tetrahydro heterocyclic ring having from 1 to 3 heteroatoms selected from N, 0, and S, R" is H, alkyl, or substituted alkyl; and R'g is alkyl or substituted alkyl.
In another embodiment of the compounds of Formula I, R' is a 5- or 6-membered aryl, 5- or 6- membered substituted aryl, 5- or 6- membered heteroaryl, 5- or 6- membered substituted heteroaryl, 8- to 10- membered bi-cyclic heteroaryl, or 8- to 10- membered bi-cyclic substituted heteroaryl, wherein the substituted aryl or substituted heteroaryl is independently substituted with one or more substituents selected from the group consisting of alkyl, substituted alkyl, hydroxy, -O-alkyl, and -0-(substituted alkyl).
In another embodiment of the compounds of Formula I, RS is H.
In another embodiment of the compounds of Formula I, q is 0, L3 is alkylene; Ar3 is aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein the substituted aryl or substituted heteroaryl of Ar3 is substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, hydroxy, alkoxy, haloalkoxy, -NH-alkyl, -NH-(alkyl)z, -NH-acyl, -N(alkyl)-acyl, -NRa-S(O)2 Rb, -C(O)-R`, -S(O)ZRb, -S(O)ZNHRa, -C(O)-NH-Ra, and -O-alkylene-R'; R' is aryl, heterocyclyl, substituted aryl, substituted heterocyclyl, -NR7a-L5-R7b, -O-PO3R'R'd, or a phosphonate group; LS is -C(O)-, -C(O)O-, -C(O)NR7e_, -S(O2)-, -S(O)-, -S(OZ)NR'e-, or -S(O)NR'e-; R'd, R'`, R7d, and R'e are independently H, alkyl, or substituted alkyl; R' is H, alkyl, or substituted alkyl;
10. Rb is alkyl, aryl, or substituted aryl; and R'b is alkyl or substituted alkyl.
In another embodiment of the compounds of Formula I, q is 0, -L3-Ar3 is R73 is H, alkyl, substituted alkyl, hydroxy, alkoxy; or R13 is one of the following structures:

O I R~

A1 Z. d ~ . O ( \ CH2)m O
LOR7c (R10)P. 0~'I \ OR7a wherein A' is NR14 or 0; R'" is H, alkyl, or substituted alkyl; R'0 is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, alkoxyalkyl, or substituted alkoxyalkyl; m is 1 or 2; p is 0, 1, or 2;
LS is -C(O)-, -C(O)-0-, or -S(OZ)-; R'b is alkyl, substituted alkyl, heteroaryl, or substituted heteroaryl; d is 1, 2, 3, or 4; and. R7' and R'd are independently alkyl or substituted alkyl.
In another embodiment of the compounds of Formula I, R4 is H.
In another embodiment of the compounds of Formula I, p is 1; L' is alkylene; L

is a covalent bond; Ar' is aryl or substituted aryl; Ar3 is heteroaryl or substituted heteroaryl;

wherein said substituted aryl or said substituted heteroaryl is substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, haloalkyl, halo, nitro, cyano, hydroxy, amino, alkoxy, haloalkoxy, -NH-alkyl, -NH-(alkyl)Z, -NH-acyl, -N(alkyl)-acyl, -NR -S(O)Z Rb, -C(O)-R`, -S(O)ZRb, -S(O)ZNHRa, -C(O)-NH-Ra; Ra is H, alkyl, or substituted alkyl; and Rb is alkyl, aryl, or substituted aryl.
In another embodiment of the compounds of Formula I, p is 1; L' is alkylene;
-Ar'-L2-Ar2is (R")d _I-.
/;&Q
R" is H, alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, alkoxyalkyl, or substituted alkoxyalkyl; d is 1, 2, 3, or 4;
Q is a heterocyclyl having one of the following structures:

(i 12)r (R12) (R12)r r\
/J(,D2_(R12)r \ % D3-(R12)r D4 ~D3 or D5==D4 (R1 ~ (R12)r (jj12)~ `(R12)r D', D2, D3, D , and D5 are independently selected from the group consisting of C, N, 0, and S; J is CR12 or N; each R12 is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R12), r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent;
and ----- is a single or double bond. "
In another embodiment of the compounds of Formula I, p is 1; L' is alkylene; Ar'-LZ-Ar2 is (R")d (R12)r ~ ~ D1 \O ~ (R 12) , r I
D4~D3 (R12) r (R12)r D', D2, D3, and D4 are independently selected from the group consisting of C, N, 0, and S; each R'Z is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R12), r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent; and R"
is H, alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, alkoxyalkyl, or substituted alkoxyalkyl; d is 1, 2, 3, or 4; m is 1. or 2; and ----- is a single or double bond.
In another embodiment of the compounds of Formula I, p is 1; L' is alkylene;
Ar'-L2-Ar2 is . / \ (I12)r O
. =~
,~ (R12)r ~
_ ;
D4Ds (R12)r (R22)r D', D 2, D', and D' are independently selected from the group consisting of C, N, 0, and S; and each R'Z is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R'Z)r, r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent.
In another embodiment of the compounds of Formula I, p is 0; L' is alkylene; Ar' is aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein said substituted aryl or said substituted heteroaryl is substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, hydroxy, alkoxy, -NRa-S(O)Z Rb, -C(O)-R`, -S(O)ZRb, -S(O)ZNHRa, -C(O)-NH-Re, and -O-alkylene-R'; R' is aryl, heterocyclyl, substituted aryl, substituted heterocyclyl, -NR''-L5-0, -O-PO3R7`R'd, a phosphonate group; LS is -C(O)-, -C(O)O-, -C(O)NR' -, -S(OZ)-, -S(O)-, -S(Oz)NR' -, or -S(O)NR'`-; R7a, R'`, R7d, and R'e are independently H, alkyl, or substituted alkyl; R'b is alkyl or substituted alkyl, ; Ra is H, alkyl, or substituted alkyl; and Rb is 'alkyl, aryl, or substituted aryl.
In another embodiment of the compounds of Formula I, p is 0; q is 1; L' and L3 are independently alkylene; L is a covalent bond; Ar', ArZ, Ar3, and Ar4 are independently aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
wherein said substituted aryl or said substituted heteroaryl is substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, haloalkyl, hydroxy, alkoxy, and -0-alkylene-R'; R' is aryl, heterocyclyl, substituted aryl, substituted heterocyclyl, -NR''-L5-O, -O-PO3R'R7d, or a phosphonates group; L5 is -C(O)-, -C(O)O-, -C(O)NR'`-, -S(OZ)-, -S(O)-, -S(OZ)NR'e-, or -S(O)NR'e-; R7a, R'`, R7d, and R'e are independently H, alkyl, or substituted alkyl; and R'b is alkyl or substituted alkyl.
In another embodiment of the compounds of Formula I, p and q are both 0; L' and L3 are independently alkylene; Ar' and Ar3 are independently aryl or substituted aryl, wherein said substituted aryl is substituted by one or more substituents selected from the group consisting of alkoxy, haloalkoxy, -O-alkylene-R'; and R' is aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
with the proviso that Ar' and Ar3 are not both phenyl.

In another embodiment-of the compounds of Formula I, R6 is OR6a, R' is alkyl or selected from the group consisting of D A8 %S O

\ CH2)m (CH2)m \ CH2)m J
J \_J ~%

R1p~ I1p~ I1p~
( /a (R la (R/a A6 A~
%% ~ ~.
H2)m (Rl l)b (R11)d GGG... (R10)a (R12)r (R12) (R12)r D2 (R12)r D3 (R12) . ~ . >_ 4__D3 D5__D4 (Rl~ (R12)r (R12)~ (R12)r A is NR or 0; A, A, and A are independently CR R, NR , or 0, with the proviso that at least one of A6 and A7 is NR14, or 0; R' and R" are independently H, alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, alkoxyalkyl, or substituted alkoxyalkyl; R'4 and R15 are independently H, alkyl, or substituted alkyl; a and b are independently 0, 1, or 2;
m is 1 or 2; D', D2, D3, D', and DS are independently selected from the group consisting of C, N, 0, and S; each R'Z is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R''), r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent;
and ----- is a single or double bond.
In another embodiment of the compounds of Formula I, R6 is selected from the group consisting of O A9 A1o A1o 1Y2m N"*r**
~'H2C)mJA (H2C)m A
(R11)a , 11_ , and I 11 ~ )a (R )a R6d R6e R6d and R" are independently selected from the group consisting of H, alkyl, and substituted alkyl; R" is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, alkoxyalkyl, or substituted alkoxyalkyl; A9 is CR14R75, NR", or 0; j is CR'4R15 or N, with the proviso that A' and J are not both CRt4R15; R14 and R15 are independently H, alkyl, or substituted alkyl; A10 and A" are independently CR" R'5, NR", S, or 0, with the proviso that A' and A" are not both CR'" R'S; each R' and R75 is independently H, alkyl, or substituted alkyl; m is 1 or 2; and a is 0, 1, or 2.
In another embodiment of the compounds of Formula I, Rg is selected from a group consisting of R6d RSe (Rii)d (i12)r (R12 )r O Dl O D~ ~(R12)r D2 (R72) ~ ~2 r R6d R~ DaD3 Rba R~ ~, D3 \D4 (R12)r (R12), (R12)r I
(R12)r Rbd and R' are independently selected from the group consisting of H, alkyl, arid substituted alkyl; R" is H, alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, alkoxyalkyl, or substituted alkoxyalkyl; d is 1, 2, 3, or 4; D', D2, D3, D4, and DS are independently selected from the group consisting of C, N, 0, and S; each R'Z is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R'Z),, r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent; and ----- is a single or double bond.
In another embodiment of the compounds of Formula I, R6 is RsrI
Rsr2 R6d Rse O
R6d and R6are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy;
or R' and R' are taken together to form a 5- or 6- membered non-aromatic tetrahydro heterocyclic ring; Z is -NR'"_ or -0-; R14 is H, alkyl, or substituted alkyl; R6f is H, alkyl, or substituted alkyl; R6" is alkyl, haloalkyl, hydroxyalkyl, or alkoxy.
In another embodiment of the compounds of Formula I, R6 is Rsf' ~ Rsr2 R 6d Rse Z
O
Rbd and R' are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy;
or R' and R' are taken together to form a 5- or 6- membered non-aromatic tetrahydro heterocyclic ring; Z is -NR'"- or -0-; R" is H, alkyl, or substituted alkyl; R 611 is H, alkyl, or substituted alkyl; R61 is (R12)r (R12)r\ (R12)r =,D2-(R12)r <r . D3 (R12)r ~ ~ .
`
D4-~ or D5~D4 (Rl ~ (R12~r (R12)~ r (R12)r r D', D2, D3, D4, and DS are independently selected from the group consisting of C, N, 0, and S; each R72 is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R72), r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent; and ----- is a single or double bond.
In another embodiment of the compounds of Formula I, R6 is RM
I Tf2 N R
R7d R7e R' and R" are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy; R6f is H, alkyl, or substituted alkyl; R6f2 is alkyl, haloalkyl, hydroxyalkyl, or alkoxy.

In another embodiment of the compounds of Formula I, R6 is RsrI
N RM

Xp6drbRe R' and R' are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy; R6f is H, alkyl, or substituted alkyl; and R6f3 is alkyl, substituted alkyl.
In another embodiment of the compounds of Formula I, X is S(O) or S(O);
and R' is alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, wherein said heterocyclyl is selected from the group consisting of:
(i) a 5-membered aromatic, nonaromatic dihydro, or nonaromatic tetrahydro heterocyclic ring having from 1 to 4 heteroatoms selected from N, 0, and S;
and (ii) a 6-membered aromatic, nonaromatic dihydro, or nonaromatic tetrahydro heterocyclic ring having from 1 to 4 heteroatoms selected from N, 0, and S.
In another embodiment of the compounds of Formula I, X is S(O)Z and R' is methyl, ethyl, n-propyl, 2-propyl, n-butyl, 2-butyl, tert-butyl, and 2,2-dimethylpropyl In another embodiment of the compounds of Formula I, X is C(O); p is 1;
q is 0; L' and L3 are alkylene, LZ is a covalent bond; R' is -C(R1dR'e)-NR"-L6-Rg; R'd is alkyl; R'e is H; R'f is H; -0-R'e is -C(O)-O-alkyl; R6 is -C(R`d~)R6f; R6d is alkyl;

R`` is H; R6f is -NH-C(O)-O-alkyl; Ar3 is -aryl-Z'-alkylene-O-PO,RR7d; and Z' is 0 or NR''; R'a, R'`, and R7d are independently H, alkyl, or substituted alkyl.
In another embodiment of the compounds of Formula I, X is C(O); p is 1;
q is 0; L' and L3 are alkylene; LZ is a covalent bond; R' is -C(R' R")-NR"-L6 -R'g; R' is hydroxyalkyl; R' is H; R" is H; -L6-R'g is -C(O)-O-alkyl; R6 is -C(R6d R`)R6`; and R' is hydroxyalkyl; R6is H; R6f is -NH-C(O)-O-alkyl.
In another embodiment of the compounds of Formula I, X is C(O); p and q are 0; L' and L3 are alkylene; Ar3 and Ar' are independently aryl or substituted aryl, wherein the substituted aryl contains one or more substituents selected from the group consisting of alkoxy, haloalkoxy, -0-alkylene-heterocyclyl, and -O-alkylene-(substituted heterocyclyl).
In another embodiment of the compounds of Formula I, X is C(O); p is 0;
q is 1; L' and L' are alkylene; and L4 is a covalent bond.
. In another embodiment, the compounds of Formula I have one of the following structures:

N N
H OH 0 H H OH ~-OyN N.N NyO, ~ N' I N' I

H H O H H OH O H
ON NO~3oNNYo.. s OH OBn N' H O N. OH N. H
~ p HpO\

N N
I
~ ~ H OH 0 H ~` ~ H OH 0 H
HO ;O H N N N~p~ ~ N N NN Nxp~
0 O. H 0 N 3~i N
\~
H OH O H H OH O H
p~[~ _N NN N~p~ N ,N N_ ,p~
_ lpf H~ O p o H 1pf O /S

N~
N'~
. ~ H OH p S Xpl ~ ` ~ H H p H p~N NN N
N py N N Ny p, O H O
O H O C~)~/
p^-NHCOOMe N' N' ), H OH O H
H OH O H pyN NN Ny Ol N
O~N
16 ,N Ny p~ p H p O H O C~
CB ~
pN S
p^-NHS02Me p N'), N H OH p H
p p HN OH N HO H OYN N.N NxO-4o NOO, ~ O H O
O
N' I
N~I
O H OH p H
MeOxN N N NxOMe 0 H OH O ~-{
H O H O ~pxN N.N NYp-O H~ O
O
O^P=~

~
N ~ PNH OH H OH O H O Oy N N NyO-OZS~pYN N=N NxO- ~ 0 H~ O
O H O
() OEt O P OEt N' N O C~

OH OH
MeOxN N N=N NYOMe N N=Np NyO-Ph H O H O E~~ H O
H
N'~
I ~ I
H O
OH OH \
NxO~
-1 MeOJIHN N HxO~ MeOxN N OH N NO NxOMe O OO N N.H~ jly n0 0 H p H O ~ HO
~
OBn Bn N- N N~ I

H OH \ I 1 I 0 N OH N. 0 H OH OI O
p~N N.N N NH O ~ H SJ OyN N.NJLO~
O H~~ B ~ O H
~ OJ
OBn . N= ~
N' N' ~ ~
\~ H H 0 H OH p pyN N.NJLO~-N H OH
~ NHZ
ON N.NJlO O H O-'~ O^~'OYN N.
~ O H O y~ O
O,J
OBn N' N'~ PN-H h{ H O n H OH ~..E CI p~H x N.N
xN Y N N N N T N H NO NH n~' OxN N=NN O H
~~O H 7 "~ O H ~ O
=OJ
OBn N~
N'~ I

O
H OH O H H OH O HN-~
ON N.N N NH ~ O OyN N N O
0 H~ ~ ~ O H

~ N\ N

H OH O H H OH OI HN--fp OO N NH~O OO N N.HO
O./ OB

N / N , ~I
H OH p H H OH p OD~ N N.N OtBu OYN N.NJIp~~S
H 0 ~ O H NJ
O

~ N I ~ N N I

H
pYN OH N'NO HN S pl(N H OH N`N'S OYN H N.
NA'-- O
O H ~ O H
~ O H ~
OJ

/ N ~ ~ N j ~r~
H OH p H H OH p O N N N, ~ O H O2 O3OO N HJ~p SOZ
N / N D
~ I O
H OH H }~ OH = N-p pO N NH Np~ O N N.HO
B IOI O/

N ) H Oli O H H OH p H
N
O pYN N.S.NMeZ OYN N NNpJ
~ p H 02 ~ O H~ IO~

N ~ I
I
H OH p H H OH O H
n~' pYN N.N N CF3 OYN N.N N.S.Et ~ O H ~ ~ O H 02 N=1 ' N,,~N

) H H O H
H H H N O~N NN N~Ol OxN N. H IN XO~ C(~ O H O

O OI

/
N-N g /
`I N N ~10 N
H H O H H OH O H
O~
J N N.N xO- OY N N.N NxO-~ O H N 0 O~ O H~O
O

S~-~
\I N tBu \I ~N

H OH O H H OH O H
Q_N NN NxO, O~N N.N 4Nyo' CB 10f H O O O 0H O
O

N

H OH O
p y N 3ON)NO
H H O NO HO 0 H~O
p / S
OCH3 N"-\ ) i I O N
H OH I O ~

pON N.H~NOO~ py N .N Ny p~
0S ~
O H~ O

~

p pON N.HNOp- O pON N.H pO/ ~~Yo, B

N
~O
N
H H O F{ H H O
Oy N N.N N~O O pyN N.N NYO5 O HO O H~O
C~~ O

~, O
H H p H ~J
~~ PO
O` ,N NN NyOl ~-{ . OH O lpf H O O py N .N NYp' p 3 O H~ O
~ B

H OH O
H OH O H Ou N N. N O~
O O N N,NN O O II H y c H O O O
~o3 NHAc O

H OH H OYN NN NYO, H OH H
PO
CB p H O DyN tNNYO, O O H O

N O N>

H OH O H H H O H
p~ ~N N.N ~O\ Oy N'N NYO`
10( H O O H 0 O S N

~N ~ N J

H OH O H H H O H
N N, O O N, O1%
O H O H O
N
' H
0\
O ~ N\N 0 NH

O H IOI
~ \ .

S \
/
N
N
H p H
N
O~ p H H p H
~3OYNN~
p H ~ N N,N Nup1 \ O H IO~

I N
H \

N O~ H H O H
O N N F{
0 H 0 ~N N, N NyO~
O O H O
\ \

\I

H OH H H OH O
u N
O
II NYO~ O OY N N.N Nu0\
p H p p H IOI
O I~ = O
N
/ I N

F
/
( H OH O H H OH O F H

O II N N`N N II O O II N N=N N II O\
O H O O H O
o o S N

F F
F F / I
~ F
H OH O H H OH O

O II N N\N II O\ O O II N N=N NyO\
O H O O H O
O O
N. N
/ / .
CI / / CI
\ I \ I

H OH O H OH O H
~3OYN4NYO
\ O OyN N= N N II O\
O' H O O H O
o o N N
CI CI
b OH O OH O F
puN NN Nu0\ O ~3OYN NH 'OI
o o N N
and F
CI

H OH O H
O O II N N=N Ik O~
O H O
O

N
I ~ -. , , or a pharmaceutically acceptable salt, solvate, and/or ester thereof, and also including stereoisomers or mixtures of stereoisomers thereof. One skilled in the art will recognize that stereoisomers or mixtures of stereoisomers of the compounds of the present application include enantiomers, diastereomers, and other stereoisomers. For example, for:

N
~I

*OYN N.N YO, O H O

contemplated stereoisomers include at least:

~ N I ~ N~ I
~~N OH N-N Ny O. *~N OH N-N~.Ny Ol N

H OH O H H OH O H
*OYN N.N N~O. *OYN N=N~.N~.O.

N

H OH. O H H OH O H
*OyN,_,J,N.N NyO,, *OyN-_,XNNJ~,NXO, O H~O 0 H~O
, ~ N I N I
H OH O H H QH
O H
~-OYN,i~~N.N 0 O, *OYN-_i,,.,N.NJ,,,NyO, O - H~O O - Hi~O
as well as mixtures of two or more of these stereoisomers.
In still another embodiment of the compounds of Formula I, n is 0, X is H, alkyl, or substituted alkyl wherein alkyl and substituted alkyl are as defined and exemplified herein.
In still another embodiment of the compounds of Formula I, n is 1, X is -C(O)-, -S(O)Z , or -S(O)-, wherein alkyl, substituted alkyl are as defined and exemplified herein.
In still another embodiment of the compounds of Formula I, n is 1 X is -S-and R6 is alkyl or substituted alkyl. Non-limiting examples of alkyl include methyl, ethyl, n-propyl, 2-propyl, n-butyl, 2-butyl, tert-butyl, and 2,2-dimethylpropyl.
In still another embodiment of the compounds of Formula I, n is 1; X is -C(O)-and R6 is -OR' wherein R6o is alkyl, or substituted alkyl. Non-limiting examples of alkyl or substituted alkyl include -CH3, -CH(CH)Z, -C(CH3)3, -CH(alkyl), -CH(substituted alkyl), -CH(heteroalkyl), -C(alkyl)Z, -C(substituted alkyl)Z, -C(heteroalkyl)õ -C(alkyl)(substituted alkyl), -C(heteroalkyl)(substituted alkyl), and -C(alkyl)(heteroalkyl), wherein alkyl, substituted alkyl, and heteroalkyl are as defined and exemplified herein.
In still another embodiment of the compounds of Formula I, n is 1; X is -C(O)-and R6 is -OR6a wherein R' is aryl, substituted aryl, arylalkyl, or substituted arylalkyl, and wherein said substituted arylalkyl is substituted on the aryl moiety and wherein aryl or arylalkyl is any aryl or arylalkyl defined or exemplified herein, and, when present, the substituents on said aryl include one.
or more of any substituents defined or exemplified herein. In a particular embodiment, aryl or the aryl portion of arylalkyl is phenyl.
In still another embodiment of the compounds of Formula I, n is 1; X is -C(O)-; and R6 is -0R' wherein R' is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, substituted heterocyclyl alkyl, wherein said substituted heterocyclyl alkyl is substituted on the heterocyclyl moiety and wherein heterocyclyl or heterocyclyl alkyl is any heterocyclyl or heterocyclyl alkyl defined or exemplified herein, and, when present, the substituents on said heterocyclyl include one or more of any substituents defined or exemplified herein. In a particular embodiment, R~ is heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl.
In still another embodiment of the compounds of Formula I, n is 1, X is -C(O)-; and R6 is C(R6dR6e)-NR6F1-C(O)-O-R" wherein e, R`eR6f or R'" are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein alkyl is any alkyl defined or exemplified herein. In one particular embodiment, one of R6d and W` is H, the other is isopropyl, and R" is methyl.
In still another embodiment of the compounds of Formula I, n is 1, X is -C(O)-; and R6 is C(eR)-O-aryl wherein R`d, R' are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein alkyl and aryl is any alkyl and aryl defined or exemplified herein.
In still another embodiment of the compounds of Formula I, n is 1 X is -C(O)-, R6 is C(R6dR6e)-NR6f-C(O)-O-R6`2 wherein R6d, R6' or R6" are independently selected from the group consisting of H, alkyl, and substituted alkyl and R6' is aryl, arylalkyl, substituted arylalkyl, wherein said substituted arylalkyl is substituted on the aryl moiety and wherein aryl or arylalkyl is any aryl or arylalkyl defined or exemplified herein, and, when present, the substituents on said aryl include one or more of any substituents defined or exemplified herein.
In a particular embodiment, aryl is phenyl.
In still another embodiment of the compounds of Formula I, n is 1, X is -C(O)- and R6 is C(R6dR6e)-NR6f-C(O)-O-R6`Zwherein R' and R6" are taken together to form a 5- or 6- membered spiro-fused non-aromatic tetrahydro heterocyclyl wherein heterocyclyl is any heterocyclyl defined or exemplified herein, and, when present, the substituents on said heterocyclyl include one or more of any substituents defined or exemplified herein.
In still another embodiment of the compounds of Forrriula I, n is 1, X is -C(O)- and R6 is C(R6dR6e)-NR6f-C(O)-NRW"-R"2wherein R~, R' or R6" are independently selected from the group consisting of H, alkyl, and substituted alkyl and R6F2 is alkyl or substituted alkyl, wherein heterocyclyl is any heterocyclyl defined or exemplified herein, and, when present, the substituents on said heterocyclyl include one or more of any substituents defined or exemplified herein.
In still another embodiment of the compounds of Formula I, n is 1, X is -C(O)- and R6 is C(R'dR'e)-NR7"-C(O)-R"" wherein R'd and R'e are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy; R7" is H, alkyl, or substituted alkyl; R""
is alkyl, haloalkyl, hydroxyalkyl, or alkoxy, wherein said alkyl, haloalkyl, hydroxyalkyl, or alkoxy are herein defined and exemplified.
In still another embodiment of the compounds of Formula I, n is 1, X is -C(O)- and R6 is C(R6dR6e)-NR6f-S(O)Z R6`3 , R6dand R' are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy; R6F is H, alkyl, or substituted alkyl; and R6`3 is alkyl, substituted alkyl, wherein said alkyl, haloalkyl, hydroxyalkyl, or alkoxy are herein defined and exemplified.
In still another embodiment of the compounds of Formula I, n is 1, X is -C(O)- and R6 is C(eR6e)-NR6f-S(O)Z N(alkyl)Z, R" and R6, are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy; RW" is H, alkyl, or substituted alkyl, wherein said alkyl, haloalkyl, hydroxyalkyl, or alkoxy are herein defined and exemplified.
In still another embodiment of the compounds of Formula I, n is 1, X is -C(O)- and R 6 is heterocyclyl or substituted heterocyclyl, wherein X is attached to the heterocyclyl through a heteroatom and wherein said heterocyclyl includes any heterocyclyl defined or exemplified herein. The substituents, when present, include one or more of any substituent defined or exemplified herein.

In still another embodiment of the compounds of Formula I, n is 1, X is -C(O)- and R6 heterocyclyl or substituted heterocyclyl, X is attached to the heterocyclyl through a carbon atom and wherein said heterocyclyl includes any heterocyclyl defined or exemplified herein. The substituents, when present include one or more of any substituent defined or exemplified herein.
In still another embodiment of the compounds of Formula I, L' is alkylene or substituted alkylene. Non-limiting examples of L' include -CHZ ,-CH(CH3)-, -CH(-CHZCH3)-, -CH(-CHZCHZCH3)-, -CH(-CH(CH3)Z)-, -CH(-CHZCHZCHZCH3)-, -CH(-CHZCH(CH3)Z)-, -CH(-CH(CH3)CHZCH3)-, -CH(-C(CH33)-, -C(CH)Z , -CH(OCH3)-, -CH(CHZOH)-, -CH(CH2CHZOH)-, etc.
In still another embodiment of the compounds of Formula I, L' is an alkylene or substituted alkylene. Non-limiting examples of alkylene and substituted alkylene include any of the alkylenes defined or disclosed herein.
For example, substituted alkylenes include alkylenes substituted with one or more -OH group, alkylenes substituted with one or more ether group, e.g., a -O-Bn group, alkylenes substituted with one or more halogen, or alkylenes substituted with combinations of two or more substituents (e.g., -OH and halogen, halogen and ether, etc.).
In still another embodiment of the compounds of Forrnula I, L' and L3 are the same, i.e., L' and L3 are the same alkylene or substituted alkylene group.
In still another embodiment of the compounds of Formula I, L' and L3 are different, i.e., L' is an alkylene and L3 is a substituted alkylene, L' is an alkylene and L3 is a different alkylene, or L' is a substituted alkylene, and L' is a different substituted alkylene.
In still another embodiment of the compounds of Formula I, LZ each L' are independently selected from the group consisting of a covalent bond, -0-, -NH, -O-alkylene-, and alkylene.
In still another embodiment of the compounds of Formula I, LZ and L' are different. For example, L2 is a covalent bond and L' is -0-; Lz is a covalent bond and L' is -NH-; L' is a -0-, L' is -NH-.

In still another embodiment of the compounds of Formula I, L' is -CH4-andpis0.
In still another embodiment of the compounds of Formula I, L' is -CHZ
andqis0.
In still another embodiment of the compounds of Formula I, L3 is -CHZ
andpis0.
In still another embodiment of the compounds of Formula I, L3 is -CH2-and q is 0.
In still another embodiment of the compounds of Formula I, Ar' is substituted or unsubstituted aryl, wherein aryl is any aryl defined or exemplified herein, and, when present, the substituents on said aryl include one or more of any substituents defined or exemplified herein. Non-limiting examples of aryl include phenyl, substituted benzene, naphthalene, anthracene, biphenyl, and the like. In a particular embodiment, Ar' is phenyl.
In still another embodiment of the 'compounds of Formula I, Ar' is substituted or unsubstituted heteroaryl, wherein heteroaryl is any heteroaryl defined or exemplified herein, and, when present, the substituents on said heteroaryl include one or more of any substituents defined or exemplified herein.
In still another embodiment of the compounds of Formula I, Ar2 is substituted or unsubstituted aryl, wherein aryl is any aryl defined or exemplified herein, and, when present, the substituents on said aryl include one or more of any substituents defined.or exemplified herein. In a particular embodiment, Ar2 is phenyl or substituted phenyl.
In still another embodiment of the compounds of Formula I, Ar2 is substituted or unsubstituted heteroaryl, wherein heteroaryl is any heteroaryl defined or exemplified herein. Non-limiting examples of heteroaryl include thienyl, furyl, oxazolyl, isoxazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyridazinyl, indazolyl, imidazopyridinyl, indolyl, benzimidazolyl, isoquinolinyl and quinolinyl.

In still another embodiment of the compounds of Formula I, Ar' is substituted or unsubstituted aryl, wherein aryl is any aryl defined or exemplified herein, and, when present, the substituents on said aryl include one or more of any substituents defined or exemplified herein. In a particular embodiment, Ar' is phenyl or substituted phenyl.
In still another embodiment of the compounds of Formula I, Ar3 is substituted or unsubstituted heteroaryl, wherein heteroaryl is any heteroaryl defined or exemplified herein, and, when present, the substituents on said heteroaryl include one or more of any substituents defined or exemplified herein. Non-limiting examples of heteroaryl include thienyl, furyl, oxazolyl, isoxazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyridazinyl, indazolyl, imidazopyridinyl, indolyl, benzimidazolyl, isoquinolinyl and quinolinyl.
In still another embodiment of the compounds of Formula I, Ar4 is substituted or unsubstituted aryl, wherein aryl is any aryl defined or exemplified herein, and, when present, the substituents on said aryl include one or more of any substituents defined or exemplified herein. In a particular embodiment, Ar4 is phenyl or substituted phenyl.
In still another embodiment of the compounds of Formula I, Ar4 is substituted or unsubstituted heteroaryl, wherein heteroaryl is any heteroaryl defined or exemplified herein. Non-limiting examples of heteroaryl include thienyl, furyl, oxazolyl, isoxazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyridazinyl, indazolyl, imidazopyridinyl, indolyl, benzimidazolyl, isoquinolinyl and quinolinyl. .
In still another embodiment of the compounds of Formula I, L' is alkylene, Ar' is substituted or unsubstituted aryl, wherein aryl is any aryl defined or exemplified herein, and the substituents on said aryl are any substituents defined and exemplified herein. In a particular embodiment, Ar' is phenyl or substituted phenyl.
In still another embodiment of the compounds of Formula I, L' is alkylene and Ar' is substituted or unsubstituted heteroaryl, wherein heteroaryl is any heteroaryl defined or exemplified herein, and, when present, the substituents on said heteroaryl include one or more of any substituent defined 'or exemplified herein.
In still another embodiment of the compounds of Formula I, L3 is substituted or.unsubstituted alkylene, and Ar3 is substituted or unsubstituted aryl, wherein alkylene and aryl are any alkylene or aryl defined or exemplified herein, and, when present, the substituents on said alkylene or aryl include one or more of any substituents defined or exemplified herein.
In still another embodiment of the compounds of Formula I, L3 is substituted or unsubstituted alkylene, and Ar' is substituted or unsubstituted heteroaryl, wherein alkylene and heteroaryl are any alkylene or heteroaryl defined or exemplified herein, and, when present, the substituents on said alkylene or heteroaryl include one or more of any substituents defined or exemplified herein.
In still another embodiment of the compounds of Formula I, Ar' is substituted or unsubstituted aryl, and Ar3 is substituted or unsubstituted heteroaryl, wherein aryl and heteroaryl are any aryl or heteroaryl defined or exemplified herein, and, when present, the substituents on said aryl or heteroaryl include one or more of any substituents defined or exemplified herein.
In still another embodiment of the compounds of Formula I, Ar3 is substituted or unsubstituted aryl, and Ar' is substituted or unsubstituted heteroaryl, wherein aryl and heteroaryl are any aryl or heteroaryl defined or exemplified herein, and, when present, the substituents on said aryl or heteroaryl include one or more of any substituents defined or exemplified herein.
In still another embodiment of the compounds of Formula I, both Ar' and Ar' are substituted or unsubstituted aryl, wherein aryl is any aryl defined or exemplified herein, and, when present, the substituents on said aryl include one or more of any substituents defined or exemplified herein.
In still another embodiment of the compounds of Formula I, LZ is a bond, Ar2 is aryl, substituted aryl, wherein the aryl is any aryl defined or exemplified herein, and, when present, the substituents on the aryl include one or more of any substituents defined or exemplified herein.
In still another embodiment of the compounds of Formula I, L2 is a bond, Ar 2 is heteroaryl, or substituted heteroaryl, wherein the heteroaryl is selected from the group consisting of thienyl, furyl, oxazolyl, isoxazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyridazinyl, indazolyl, imidazopyridinyl, indolyl, benzimidazolyl, isoquinolinyl and quinolinyl.
In still another embodiment of the compounds of Formula I, LZ is 0-alkylene (wherein the alkylene group is attached to either Ar' or Ar'`), ArZ
is heteroaryl, or substituted heteroaryl, wherein the heteroaryl is selected from the group consisting of thienyl, furyl, oxazolyl, isoxazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyridazinyl, indazolyl, imidazopyridinyl, indolyl, benzimidazolyl, isoquinolinyl and quinolinyl.
In still another embodiment of the compounds of Formula I, p is 0, and Ar' is unsubstituted aryl.
In still another embodiment of the compounds of Formula I, p is 0, and Ar' is aryl substituted with haloalkoxy.
In still another embodiment of the compounds of Formula I, two of the Ar', Ar2, Ar3, or Ar4 are the same and the remaining two are different, e.g.
two of Ar', Ar2, Ar3, or Ar" are substituted or unsubstituted aryls and the other two of Ar', Ar2, Ar3, or Ar4 are substituted or unsubstituted heteroaryls, wherein aryl and heteroaryl are any aryl or heteroaryl defined or exemplified herein, and, when present, the substituents on the aryl or heteroaryl include one or more of any substituents defined or exemplified herein.
In still another embodiment of the compounds of Formula I, q is 0, and Ar3 is unsubstituted aryl.
In still another embodiment of the compounds of Formula I, q is 0, and Ar3 is substituted aryl wherein the substituents are selected from the group consisting of hydroxyl, alkoxy, haloalkoxy. -Z'-alkylene-R'; R' is -Z2 -L5-R7b, or -O-PO,R'`R'd; L5 is -C(O)-, -C(0)0-, -C(O)NR-, -NR -S(O)2 Rb, -C(O)-R`, -S(O)ZRb, -S(O)ZNHRa, -C(O)-NH-Ra, -S(O)Z , -S(O)-, -S(O)ZNR'e-, or -S(O)NR'`-; Z' and Z2 are independently 0 or NR'a; R'`, R7d, and R'e are independently H, alkyl, or substituted alkyl;
R'b is alkyl, substituted alkyl, heterocyclyl, or substituted heterocyclyl;
Ra is H, alkyl, or substituted alkyl; and Rb is alkyl, aryl, or substituted aryl.
In still another embodiment of the compounds of Formula I, L4 is a covalent bond, Ar4 is aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein the aryl or heteroaryl are any aryl or heteroaryl defined or exemplified herein, and, when present, the substituents on the aryl or heteroaryl include one or more of any substituents defined or exemplified herein.
In still another embodiment of the compounds of Formula I, q is 1, L4 is a covalent bond, Ar" is aryl, substituted aryl, wherein the aryl is any aryl defined or exemplified herein, and, when present, the substituents on the aryl include one or more of any substituents defined or exerriplified herein such as -NH-acyl.
In still another embodiment of the compounds of Formula I, q is 1, L' is a covalent bond, Ar4 is heteroaryl, or substituted heteroaryl, wherein the heteroaryl is selected from the group consisting of thienyl, furyl, oxazolyl, isoxazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyridazinyl, indazolyl, imidazopyridinyl, indolyl, benzimidazolyl, isoquinolinyl and quinolinyl.
In still another embodiment of the compounds of Formula I, q is 1, L is 0-, Ar4 is aryl, or substituted aryl. In a particular embodiment, Ar' is phenyl.
In still another embodiment of the compounds of Formula I, q is 1, L4 is 0-alkylene (wherein the alkylene portion of the -0-alkylene group is attached to.
either Ar3 or Ar'), Ar4 is heteroaryl, or substituted heteroaryl, and wherein the heteroaryl is selected from the group consisting of thienyl, furyl, oxazolyl, . isoxazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyridazinyl, indazolyl, imidazopyridinyl, indolyl, benzimidazolyl, isoquinolinyl and quinolinyl.
In still. another embodiment of the compounds of Formula I, R' is OR'`, wherein R'` is alkyl or substituted alkyl. Non-limiting examples of alkyl are methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, or tert-butyl.

In still another embodiment of the compounds of Formula I, R' is OR", wherein R" is arylalkyl, substituted arylalkyl, heterocyclyl alkyl, and substituted heterocyclyl alkyl, wherein alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, arylalkyl, substituted arylalkyl, heterocyclyl alkyl, and substituted heterocyclyl alkyl are any alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, arylalkyl, substituted arylalkyl, heterocyclyl alkyl, and substituted heterocyclyl alkyl defiiied or exemplified herein.
In still another embodiment of the compounds of Formula I, R' is OR'`, wherein R" is aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, wherein the aryl, substituted aryl, heterocyclyl, and substituted heterocyclyl are any aryl, substituted aryl, heterocyclyl, substituted heterocyclyl defined or exemplified herein In still another embodiment of the compounds of Formula I, R' is OR'`, wherein R'` is selected from the group consisting of A\ O A2 As Aa (CH2)m \ CH2)m /~
`~~"~ ~ `~\/~ (R8)b r~
(R8). (R8)a (R8)a wherein A', AZ, A', and A' are 0, and m is 1.
In still another embodiment of the compounds of Formula I, R' is aryl or substituted aryl, wherein aryl is any aryl defined or exemplified herein and, when present, the substituents on the aryl include one or more of any substituents defined or exemplified herein such as hydroxyl or methyl.
In still another embodiment of the compounds of Formula I, R' is heteroaryl or substituted heteroaryl, wherein heteroaryl is any heteroaryl defined or exemplified herein.
In still another embodiment of the compounds of Formula I, R' is -C(R'dR'e)-NR"-C(O)-O-R'g wherein R'd, R'e, and R" are independently H, alkyl, or substituted alkyl, and R'g is alkyl or substituted alkyl wherein alkyl and substituted alkyl include any of the alkyl or substituted alkyls defined or disclosed herein. For example, R'd, R'e, and R" may indenpendently be methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, or tert-butyl or substituted methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, or tert-butyl wherein the substituents may include a hydroxyl group.
In still another embodiment of the compounds of Formula I, R' is -C(R1dR' )-NR"-C(O)-O-R'g wherein R" and R' taken together with the carbon atom to which they are shown attached form a heterocyclyl or a substituted heterocyclyl, wherein said heterocyclyl or said substituted heterocyclyl is a 5- or 6- membered non-aromatic tetrahydro heterocyclic ring having from 1 to 3 heteroatoms selected from N, 0, and S, R" is H, alkyl, or substituted alkyl, and R'g is alkyl or substituted alkyl wherein alkyl, substituted alkyl, heterocyclyl or a substituted heterocyclyl include any of the alkyl, substituted alkyl, heterocyclyl, or substituted heterocyclyl defined or disclosed herein.
In still another embodiment of the compounds of Formula I, R2, R", and RS
are each independently H, alkyl, or substituted alkyl, whereiri alkyl and substituted alkyl include any of the alkyl or substituted alkyls defined or disclosed herein.
In still another embodiment of the compounds of Formula I, R2, R4, and RS
are each the same. In a particular embodiment RZ, R4, and RS are each H. In another particular embodiment R', R', and RS are each alkyl, e.g. one of the alkyl groups defined or disclosed herein.
In still another embodiment of the compounds of Formula I, Rz, R', and RS
are each different.
In still another embodiment of the compounds of Formula I, two of R2, R4, and RS are the same, and the other is different.
In still another embodiment of the_compounds of Formula I, p is 0, q is 1, R2, R4, and RS are each independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein alkyl or substituted alkyl is any alkyl or substituted alkyl, defined or disclosed herein.
In still another embodiment of the compounds of Formula I, p is 1, q is 0, R2, R", and R5 are each independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein alkyl or substituted alkyl is any alkyl or substituted alkyl, defined or disclosed herein.
In still another embodiment of the compounds of Formula I, p and q are both 1, and RZ is H.
In still another embodiment of the compounds of Formula I, p and q are both 1, and R4 is H.
In still another embodiment of the compounds of Formula 1, p and q are both 1, and RS is H.
In still another embodiment of the compounds of Formula I, p is 0, q is 1, and RZ is H.
In still another embodiment of the compounds of Formula I, p is 0, q is 1, and R4 is H.
In still another embodiment of the compounds of Formula I, p is 0, q is 1, and R5 is H.
In still another embodiment of the compounds of Formula I, p is 1, q is 0, and R2 is H.
In still another embodiment of the compounds of Formula I, p is 1, q is 0, and R4 is H.
In still another embodiment of the compounds of Formula I, p is 1, q is 0, and R5 is H.
In still another embodiment of the compounds of Formula I, p is 1, q is 0, R' is -NR'R'b, -OR'`, -C(R' R7e)-NR"-L6 -R'g, aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein aryl, substituted aryl, heteroaryl, or substituted heteroaryl is any aryl, substituted aryl, heteroaryl, or substituted heteroaryl, defined or disclosed herein.
In still another embodiment of the compounds of Formula I, p and q are both 1, and R' is -NR''R'b, -OR'`, -C(R1dR'e)-NR"-L6 -R'g, aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein aryl, substituted aryl, heteroaryl, or substituted heteroaryl is any aryl, substituted aryl, heteroaryl, or substituted heteroaryl, defined or disclosed herein.

In still another embodiment of the compounds of Formula I, p is 0, q is 1, and R' is -NR''R'b, -OR'`, -C(R'dR7e)-NR"-L6-R'8, aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein aryl, substituted aryl, heteroaryl, or substituted heteroaryl is any aryl, substituted aryl, heteroaryl, or substituted heteroaryl, defined or disclosed herein.
In yet another embodiment of the compounds of Formula I, q is 0, the -L3-Ar3-(L -Ar4)q moiety is an -alkylene-aryl group, wherein said alkylene and aryl moieties are any alkylene and aryl moieties defined or exemplified herein, optionally substituted on the alkylene and/or aryl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, q is 1, the -L3-Ar'-(L4-Ar4)q moiety is an -alkylene-aryl-aryl group, wherein said alkylene and aryl moieties are any alkylene and aryl moieties defined or exemplified herein, optionally substituted on the alkylene and/or aryl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, q is 1, the -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl-heteroaryl group, wherein said alkylene, aryl, and heteroaryl moieties are any alkylene, aryl, and heteroaryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, q is 1, the -L'-Ar3-(L4-Ar")q moiety is an-alkylene-aryl-O-aryl group, wherein said alkylene and aryl moieties are any alkylene and aryl moieties defined or exemplified herein, optionally substituted on the alkylene and/or aryl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, q is 1, the -L3-Ar'-(L'-Ar")q moiety is an -alkylene-aryl-CHZ-O-heteroaryl group, wherein said alkylene, aryl, and heteroaryl moieties are any alkylene, aryl, and heteroaryl moieties defined or exemplified herein, optionally substituted on the alkylene, heteroaryl, and/or aryl with one or more of any substituents defined or exemplified herein.

In yet another embodiment of the compounds of Formula I, q is 1, the -L3-Ar3-(L4-Ar4) with q moiety is an -alkylene-aryl-O-CHZ-heteroaryl group, wherein said alkylene, aryl, and heteroaryl moieties are any alkylene, aryl and heteroaryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, q is 1, the -L'-Ar3-(L'-Ar )q moiety is an -alkylene-aryl-O-alkylene-NH-C(O)-O-alkyl group, wherein said alkylene, alkyl and aryl moieties are any alkylene, alkyl, and aryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, q is 1, the -L3-Ar3-(L'-Ar")q moiety is an -alkylene-aryl7O-alkylene-NH-S(O)Z alkyl group, wherein said alkylene, alkyl, and aryl moieties are any alkylene, alkyl, and aryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, q is 1, the -L3-Ar3-(L'-Ar')q moiety is an -alkylene-aryl-O-alkylene-NH-C(O)-heterocyclyl group, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, q is 1, the -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl-O-alkylene-PO,(alkyl)2 group, wherein said alkylene and aryl moieties are any alkylene and aryl moieties defined or exemplified herein, optionally substituted on the alkylene and/or aryl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(L2-Ar2)P moiety is an -alkylene-aryl group, wherein said alkylene and aryl moieties are any alkylene and aryl moieties defined or exemplified herein, optionally substituted on the alkylene and/or aryl with one or more of any substituents defined or exemplified herein.

In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, wherein said alkylene, aryl, and heterocyclyl moieties are any alkylene, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene and/or aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L2-ArZ)P moiety is an -alkylene-aryl-O-alkylene=heterocyclyl group, wherein said alkylene, aryl, and heterocyclyl moieties are any alkylene, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene and/or aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(L2-ArZ)P is an -alkylene-aryl-O-haloalkyl group, wherein said alkylene, haloalkyl, and aryl moieties are any alkylene, haloalkyl, and aryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(L2-ArZ)P moiety is an -alkylene-aryl group, q is 1, the -L'-Ar'-(L4-Ar4)q moiety is an -alkylene-aryl-heteroaryl group, wherein said alkylene, aryl, 'and heteroaryl moieties are any alkylene, aryl, and heteroaryl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heteroaryl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl group, q is 1, the '-L3-Ar3-(L'-Ar4)q moiety is an -alkylene-aryl-O-CHZ-heteroaryl group, wherein said alkylene, aryl, and heteroaryl moieties are any alkylene, aryl, and heteroaryl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heteroaryl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(LZ-Ar')P moiety is a -alkylene-aryl group, q is 1, the -L3-Ar'-(L'-Ar )q moiety is an -alkylene-aryl-aryl group, wherein said alkylene and aryl moieties are any alkylene and aryl moieties defined or exemplified herein, optionally substituted on the alkylene and/or aryl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Ar~)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L3-Ar3 -(L4-Ar4)q moiety is an -alkylene-aryl group, wherein said alkylene, heterocyclyl and aryl moieties are any alkylene, heterocyclyl, and aryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein such as hydroxyl and alkoxy.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L2-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl-O-CHZ-aryl group, wherein said alkylene, heterocyclyl and aryl moieties are any alkylene, heterocyclyl, and aryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L2-Ar'-)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L'-Ar')q moiety is an -alkylene-aryl-O-CHZ-heterocyclyl group, wherein said alkylene, heterocyclyl, and aryl moieties are any alkylene, heterocyclyl, and aryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L2-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -0-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl-O-alkylene-NH-C(O)-O-alkyl group, wherein said alkylene, alkyl, heterocyclyl, and aryl moieties are any alkylene, alkyl, heterocyclyl, and, and aryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L2-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L4-Ar')q moiety is an -alkylene-aryl-O-alkylene-NH-S(O)Z O-alkyl group, wherein said alkylene, alkyl, heterocyclyl, and aryl moieties are any alkylene, alkyl, heterocyclyl, and, and aryl moieties defined or exemplified herein, optionally substituted with one or niore of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L2-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3=Ar'-(L4-Ar4)q moiety is an -alkylene-aryl-O-alkylene-NH-C(O)-heteroaryl group, wherein said alkylene, alkyl, heterocyclyl, aryl, and heteroaryl moieties are any alkylene, alkyl, heterocyclyl, aryl, and heteroaryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L"-Ar4)q moiety is an -alkylene-aryl-O-alkylene-PO3(alkyl)Z group, wherein said alkylene, alkyl, heterocyclyl, and aryl moieties are any alkylene, alkyl, heterocyclyl, and aryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L2-Ar2)P moiety is an -alkylene-aryl-O-alkylene-heterocyclyl group, -q is 0, the -L3-Ar3-(L4-Ar4)9 moiety is an -alkylene-aryl group, wherein said alkylene, aryl, and heterocyclyl moieties are any alkylene, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene and/or aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of- Formula I, p is 0, the -L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl-O-haloalkyl, q is 1, the -L3-Ar3-(L -Ar`)q moiety is an -alkylene-aryl-heteroaryl group, wherein said alkylene, haloalkyl, aryl, and heteroaryl moieties are any alkylene, haloalkyl, aryl, and heteroaryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.

In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl-O-haloalkyl group, q is 0, the -L3-Ar3-(L'-Ar")q moiety is an -alkylene-aryl-O-alkyl group, wherein said alkylene, alkyl, haloalkyl, and aryl, moieties are any alkylene, alkyl, haloalkyl, and aryl heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents ~defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl group, q is 1, the -L3-Ar3-(L'-Ar4)q moiety is an -alkylene-aryl-heteroaryl group, R' is OR", wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, alkyl, heterocyclyl, aryl, and heteroaryl moieties are any alkylene, alkyl, heterocyclyl, aryl, and heteroaryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl group, q is 1, the -L'-Ar'-(L4-Ar9)q moiety is an -alkylene-aryl-O-CHZ-heteroaryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, alkyl, heterocyclyl, aryl, and heteroaryl moieties are any alkylene, alkyl, heterocyclyl, aryl, and heteroaryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl group, q is 1, -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl-aryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, -L3-Ar3-(L'-Ar")q moiety is an -alkylene-aryl group, R' is OR'`, wherein R" is alkyl or substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein:
. In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L'-Ar3-(L4-Ar )q moiety is an -alkylene-aryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the =L3-Ar3-(L"-Ar4)q rrioiety is an -alkylene-aryl group, R' is aryl or substituted aryl, wherein said alkylene, aryl, and heterocyclyl moieties are any alkylene, aryl, and heterocyclyl moieties defined or exemplified herein; optionally substituted on the alkylene, aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein. Iri one particular embodiment, R' is optionally substituted with one or more hydroxyl and/or methyl groups.
In yet another embodiment of.the compounds of Formula I, p is 1, the -L'-Ar'-(L2-Ar')P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L'-Ar3-(L'-Ar")q moiety is an -alkylene-aryl group, R' is heteroaryl or substituted heteroaryl, wherein said alkylene, aryl, heteroaryl, and heterocyclyl moieties are any alkylene, aryl, heteroaryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)p moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L'-Ar3-(L"-Ar')q moieties is an -alkylene-aryl group, R' is arylalkyl, substituted arylatkyl, heterocyclyl alkyl, and substituted heterocyclyl alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl groi:up, q is 0, the -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl group, R' is -C(R'aR'e)-NR"-C(O)-O-R'g wherein R'd, R'e, and R" are independently H, alkyl, or substituted alkyl, and R'g is alkyl or substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, -L3-Ar3-(L'-Ar")q moiety is an -alkylene-aryl group, R' is -C(R1dR'e)-NR'f-C(O)-O-R'g wherein R'd and R'e taken together with the carbon atom to which they are shown attached form a heterocyclyl or a substituted heterocyclyl, R" is H, alkyl, or substituted alkyl, and R'g is alkyl or substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified heirein, optionally substituted on the alkylene, aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L4-Ar )q moiety is an -alkylene-aryl-O-CHZ-aryl group, R' is OR'`, wherein R"
is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
Iri yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl-O-CHZ aryl group, R' is -C(R'dR'e)-NR"-C(O)-O-R'g wherein R'd, R'e, and R" are independently H, alkyl, or substituted alkyl, and R'g is alkyl or substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)p moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L4-Ar")q moiety is an -alkylene-aryl-O-CHZ-heterocyclyl group, R' is OR", wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, alkyl, aryl, and heteroaryl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the"compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Arz)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L -Ar4)q moiety is an -alkylene-aryl-O-alkylene-NH-C(O)-O-alkyl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are'any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L4-Ar")q moiety is an -alkylene-aryl-O-alkylene-NH-S(O)2 O-alkyl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.

In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl-O-alkylene-NH-C(O)-heteroaryl group, R' is OR'`, wherein R'` is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L'-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar'-(L4-Ar4)q moiety is an -alkylene-aryl-O-alkylene-PO3(alkyl)Z group, R' is OR", wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Ar2)p moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L'-Ar3-(L"-Ar4)q moiety is an -alkylene-aryl-O-alkylene-PO3(alkyl)2 group, R' is -C(R'dR'e)-NR'f-C(O)-O-R'g wherein R'd, R'e, and R" are independently H, alkyl, or substituted alkyl, and R'g is alkyl or substituted alkyl, wherein said alkylene, alkyl, aryl, and heteroaryl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein. -In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Arz)P moiety is an -alkylene-aryl-O-alkylene-heterocyclyl group, q is 0, the -L3-Ar3-(L'-Ar")q moiety is an -alkylene-aryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, aryl, and heterocyclyl moieties are any alkylene, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene and/or aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-O-haloalkyl, -q is 1, the -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl-heteroaryl group, R' is OR'`, wherein R"
is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, aryl, and heterocyclyl moieties are any alkylene, aryl, and heterocyclyl moieties defined or exe that mplified herein, optionally substituted on the alkylene and/or aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0; the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-O-haloalkyl, -q is 0, the -L3-Ar'-(L -Ar")q moiety is a -alkylene-aryl, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene and/or aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the =
L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl group, q is 1, the -L3-Ar3-(L`-Ar')q moiety is an -alkylene-aryl-heteroaryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, R6 is C(eR6`)-NR6f-C(O)-O-R" wherein R`d, R' R`"
or R" are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heteroaryl moieties are any alkylene, alkyl, aryl, and heteroaryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl group, q is 1, the -L3-Ar3-(L"-Ar )q moiety is an -alkylene-aryl-aryr group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocydyl alkyl, X is -C(O)-, R6 is C(R6dR6`)-NR6f-C(O)-O-R" wherein R`~, R~ R611 or R14 are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(LZ-Ar'-)P moiety is an -alkylene-aryl group, q is1, the -L3-Ar3-(L -Ar4)q moiety is an -alkylene-aryl-O-CH2-heteroaryl group, R' is OR'`, wherein R'` is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, R6 is C(RWRn-NR611-C(O)-O-R" wherein e, R"`
R6"
or R" are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or "exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L'-Ar3-(L -Ar")q moiety is an -alkylene-aryl group, R' is OR'", wherein R" is alkyl or substituted alkyl, X is -C(O)-, R6 is C(R6dR6`)-NR6f-C(O)-O-R" wherein R6d, R`
R6"
or R14 are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heteroaryl moieties are any alkylene, alkyl, aryl, and heteroaryl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L2-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L'-Ar3-(L4-Ar )q moiety is an -alkylene-aryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, R6 is C(R6dR6`)-NR6f-C(O)-O-R" wherein e, R`` R 611 or R14 are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the --L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L3-Ar3 (L4 -Ar )q moiety is an -alkylene-aryl group, R' is aryl or substituted aryl, X is -C(O)-, and R6 is C(R6dR6e)-NR6f-C(O)-O-R" wherein e, Re R6" or R" are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, aryl, and heterocyclyl moieties are any alkylene, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein. In one particular embodiment, R' is optionally substituted with one or more hydroxyl and/or methyl groups.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L3 -Ar3-(L'-Ar")q moiety is an -alkylene-aryl group, R' is heteroaryl or substituted heteroaryl, X is -C(O)-, and R6 is C(R6dR6e)-NR611-C(O)-O-R14 wherein R6d, R' R6f or R14 are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, aryl, and heterocyclyl moieties are any alkylene, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L2-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L'-Ar'-(L4-Ar`)q moiety is an -alkylene-aryl group, R' is arylalkyl, substituted arylalkyl, heterocyclyl alkyl, and substituted heterocyclyl alkyl, X is -C(O)-, R6 is C(R6d R6e)-NR6"-C(O)-O-R" wherein R6d, e R6" or R14 are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(Lz-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl group, R' is -C(R'dR'e)-NR"-C(O)-O-R'g wherein R'd, R7e, and R" are independently H, alkyl, or substituted alkyl, and R'g is alkyl or substituted alkyl, X is -C(O)-, and R6 is C(RR6e)-NR6f-C(O)-O-R74 wherein e, R6-R6" or R14 are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein_ R'd, R'`, Rd, and R' may optionally be substituted with a hydroxyl group.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)p moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L3-Ar3-(L9-Ar')q moiety is an -alkylene-aryl group, R' is -C(R'dR'e)-NR"-C(O)-O-R'g wherein R'd and R1e taken together with the carbon atom to which they are shown attached form a heterocyclyl or a substituted heterocyclyl, R" is H, alkyl, or substituted alkyl, and R'g is alkyl or substituted alkyl, X is -C(O)-, R6 is C(eR6`)-NR6f-C(O)-O-R6"- wherein R`d and R' are taken together to form a 5- or 6- membered spiro-fused non-aromatic tetrahydro heterocyclyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl-O-CH2-aryl group, R' is OR'`, wherein R"
is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, R6 is C(R6dR6`)-NR6"-C(O)-O-R14 wherein R6d, R6, R6f or R14 are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L'-Ar'')P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L'-Ar')q moiety is an -alkylene-aryl-O-CHZ aryl group, R' is OR", wherein R'`
is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, and R6 is C(R6dIVe)-NR6f-C(O)-O-R14 wherein R6', R, R6" or R" are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the.-L3-Ar3 -(L4-Ar4 )q moiety is an -alkylene-aryl-O-CHZ aryl group, R' is -C(R'dR'e)-NR'f-C(O)-O-R'g wherein R'd, R'`, and R" are independently H, alkyl, or substituted alkyl, and R'g is alkyl or substituted alkyl, X is -C(O)-, R6 is alkyl or substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L2-Ar')P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar'-(L4-Ar4)q moiety is an -alkylene-aryl-O-CHZ heterocyclyl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, and R6 is C(R6dR6e)-NR611 -C(O)-O-wherein R6d, R' R6f or R14 are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L4-Ar")q moiety is an -alkylene-aryl-O-alkylene-NH-C(O)-O-alkyl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, R6 is C(R6dR")-NR6f-C(O)-O-R'"
wherein R6d, R' R6" or R" are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar'-(L4-A?)q moiety is an -alkylene-aryl-O-alkylene-NH-S(O)Z O-alkyl group, R' is OR'`, wherein R'` is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, R6 is C(R6dR`)-NR611-C(O)-O-R14 wherein e, R6` R6" or R'" are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment-of the compounds of Formula I, p is*1, the -L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar'-(L'-Ar4)q moiety is an -alkylene-aryl-O-alkylene-NH-C(O)-heteroaryl group, R' is OR'`, wherein R'` is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, R6 is C(eR6`)-NR611 -C(O)-O-R"
wherein R`d, R6` R6" or R" are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl-O--alkylene-PO3(alkyl)2 group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, R6 is C(Rdl~)-NR6f-C(O)-O-R"
wherein R6d, R6` R6" or R" are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(Lz-Ar')P moiety is an -alkylene-aryl-heterocyclyl group, q is 1, the -L3-Ar3-(L4-Ar`)q moiety is an -alkylene-aryl-O-alkylene-PO3(alkyl)Z group, R' is -C(R'dR'`)-NR"-C(O)-O-R'g wherein R'd, R' , and R" are independently H, alkyl, or substituted alkyl, and R'g is alkyl or substituted alkyl, X is -C(O)-, and R6 is C(eR6e)-NR611 -C(O)-O-R" wherein e, R6` R6" or R14 are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(L2-Ar)P moiety is an -alkylene-aryl-O-alkylene-heterocyclyl"group, q is 0, -L3-Ar3-(L4-Ar4)q moiety is a -alkylene-aryl group, R' is OR'`, wherein R" is heterocyclyl, substitute of d heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, and Rb is C(R6dR6e)-NR6"-C(O)-O-R14 wherein R, R' R6f or R" are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, aryl, and heterocyclyl moieties are any alkylene, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene and/or aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 0, the -L'-Ar'-(L2-Ar2)P moiety is an -alkylene-aryl-O-haloalkyl, -q is 1, the -L3-Ar3-(L2-Ar4)q moiety is an -alkylene-aryl-heteroaryl group, R' is OR'`, wherein R'` is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, and R6 is C(R'R)-NR6F-C(O)-O-R14 wherein R6d, R' R6f or R" are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, aryl, and heterocyclyl moieties are any alkylene, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L'-Ar3-(L'-Ar4)q moiety is an -alkylene-aryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, R6 is heterocyclyl alkyl or substituted heterocyclyl alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the.-L'-Ar'-(L4-Ar4)q moiety is an -alkylene-aryl group, R' is OR'`, wherein R'` is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is --C(O)-, R6 is C(R'R)-NR6"-S(O)Z R63R' and R' are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy; R6f is H, alkyl, or substituted alkyl; and R6`3 is alkyl, substituted alkyl,, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exeniplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.

In yet another embodiment of the compounds of Formula I, p is 1, the -' L'-Ar'-(LZ-Ar')P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is =C(O)- and R6 is C(R7dR'e)-NR"'-C(O)-R"'wherein R'd and R'e are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy; R"' is H, alkyl, or substituted alkyl;
R7'2 is alkyl, haloalkyl, hydroxyalkyl, or alkoxy, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heteroaryl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Ar2)p moiety is an -alkylene-aryl-heterocyclyl group, q is 0, -L3-Ar3-(L4-Ar4)q moiety is an -alkylene-aryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)- and R6 is C(R6dR6e)-NR611 -S(O)2 N(alkyl)Z, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
-In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L3-Ar3-(1.4-Ar )q moiety is an -alkylene-aryl group, R' is OR'`,. wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)- R6 is heterocyclyl or substituted heterocyclyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L'-Ar'-(L'-Ar4)q moiety is an -alkylene-aryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)- and R6 is C(eR')-O-aryl wherein R, R6 are independently selected from the group consisting of H, alkyl, and substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L3-Ar3-(L4-Ar')q moiety is an -alkylene-aryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -S-, and R6 is alkyl or substituted alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-Ar')p moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L3-Ar3-(L -Ar )q moiety is an -alkylene-aryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)- and R6 is -0Rba wherein Rba is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, substituted heterocyclyl alkyl, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heteroaryl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar1-(LZ-Ar2)P moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L3-Ar3-(1 -Ar')q moiety is an -alkylene-aryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, R` is heterocyclyl or substituted heterocyclyl, wherein X is attached to the heterocyclyl through a heteroatom, wherein said alkylene, alkyl, aryl, and heterocyclyl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted with one or more of any substituents defined or exemplified herein. .
In yet another embodiment of the compounds of Formula I, p is 1, the -L'-Ar'-(LZ-ArZ)p moiety is an -alkylene-aryl-heterocyclyl group, q is 0, the -L3-Ar3-(L'-Ar4)q moiety is an -alkylene-aryl group, R' is OR'`, wherein R" is heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, X is -C(O)-, R6 is heterocyclyl or substituted heterocyclyl, wherein X is attached to the heterocyclyl through a carbon atom, wherein said heterocyclyl includes any heterocyclyl defined or exemplified herein, wherein said alkylene, alkyl, aryl, and heteroaryl moieties are any alkylene, alkyl, aryl, and heterocyclyl moieties defined or exemplified herein, optionally substituted on the alkylene, aryl and/or heterocyclyl with one or more of any substituents defined or exemplified herein.
In yet another embodiment of the compounds of Formula I, X is C(O); p is 0; q is 1; L' and L3 are alkylene; L4 is a covalent bond; Ar', Ar3, and Ar' are independently aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein said substituted aryl or said substituted heteroaryl of Ar', Ar3 and Ar` are each independently substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, haloalkyl, halo, hydroxy, amino, alkoxy, haloalkoxy.
In yet another embodiment of the compounds of Formula I, X is C(O); p is 0; q is 1; L' and L3 are alkylene; L4 is a covalent bond; wherein R' is OR'`;
and R"
is alkyl, substituted alkyl, heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said substituted heterocyclyl alkyl is substituted on the heterocyclyl moiety, and said heterocyclyl is selected from the group consisting of: (i) a mono-cyclic 5- or 6-membered aromatic, nonaromatic dihydro, or nonaromatic tetrahydro heterocyclic ring having from 1 to 4 heteroatoms selected from N, 0, and S; and (ii) a bi-cyclic 8-, 9-, or 10-membered aromatic, nonaromatic dihydro, or nonaromatic tetrahydro heterocyclic ring having from 1 to 6 heteroatoms selected from N, 0, and S.
Preferably, R' is OR"; and R" is selected from the group consisting of (2)m A4 CH2)m ~LJ (R )b I ~ \
(R$)a (R8)a 8).
~
wherien A', A2, A3, and A are independently NR9 or 0; Re is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, -0-(alkyl), or -O-(substituted alkyl); R9 is H, alkyl, or substituted alkyl; m is 1 or 2; and a and b are independently 0, 1, or 2.
10. In yet another embodiment of the compounds of Formula I, X is C(O); p is 0; q is 1; L' and L3 are alkylene; L is a covalent bond; R6 is Rsti ~ N
Rsrz ~ Z
Rsd Rse , wherein Rd and R' are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy; or Rbd and R' are taken together to form a or 6- membered non-aromatic tetrahydro heterocyclic ring; Z is -NR14_ or -0-;
R"
is H, alkyl, or substituted alkyl; R6t is H, alkyl, or substituted alkyl; and R6f2 is alkyl, haloalkyl, hydroxyalkyl, or alkoxy.
In yet another embodiment of the compounds of Formula I, X is C(O); p is 0; q is 1; L' and L3 are alkylene; L4 is a covalent bond; R' is OR"; and R" is selected from the group consisting of .

(CH2)m O A(Cj-~Z)`n J R)b IS ZZ.. \ 8 ( )a (Rs)a (R )a wherien A', AZ, A3, and A4 are independently NR9 or 0; R8 is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl,- substituted hydroxyalkyl, -O-(alkyl), or -0-(substituted alkyl); R9 is H, alkyl, or substituted alkyl; m is 1 or R6f1 ~ 'N-1 RM
R6d Rse 0 2; a and b are independently 0, 1, or 2; R6 is wherein R' and R' are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy; or R6d and R' are taken together to form a 5- or 6- membered non-aromatic tetrahydro heterocyclic ring; Z is -NR"_ or -0-; R" is H, alkyl, or substituted alkyl; R6f is H, alkyl, or substituted alkyl; and R6' is alkyl, haloalkyl, hydroxyalkyl, or alkoxy.
In yet another embodiment of the compounds of Formula I, X is C(O); p is 1; q is 0; L' and L3 are alkylene; L2 is a covalent bond; R' is OR'`; and R'`
is selected from the group consisting of A' A2 A3 A4 (CH2m 0(cHZ)m ` 2)m J J
A (R8)b ~
(RB)a (i 8)a (0).

wherein A', AZ, A3, and A' are independently NR9 or 0; RB is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, -O-(alkyl), or -0-(substituted alkyl); R9 is H, alkyl, or substituted alkyl; m is 1 or R6t1 Z
Rsr2 2; a and b are independently 0, 1, or 2; R6 is R6a Rse 0 wherein R6dand R6' are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy; or R6d and R' are taken together to form a 5- or 6- membered non-aromatic tetrahydro heterocyclic ring; Z is=-NR". or -0-; R' is H, alkyl, or substituted alkyl; R6f is H, alkyl, or substituted alkyl; and Rb`Z is alkyl, haloalkyl, hydroxyalkyl, or alkoxy. Preferably, Ar', ArZ, and Ar" are independently aryl, substituted aryl, heteroaryl, or substituted heteiroaryl, wherein said substituted aryl or said substituted heteroaryl of Ar', Ar2 and Ar' are each independently substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, haloalkyl, halo, hydroxy, amino, alkoxy, haloalkoxy.
In still yet another embodiment, the compounds of Formula I are named below in tabular format (Table 6) as compounds of general Formula II:

Formula II.
Compounds of general formula II are depicted as a "core" structure (Z) substituted with four moieties Tl; T2, Xl and X2. The core structures Z are depicted in Table 1. The points of attachment of Tl, T2, Xl and X2 are indicated on each of the core structures depicted in Table 1. Tables 2-5, respectively, show the structures of the T1, T2, Xl and X2 moieties. The point of attachrnent of the core structure Z is indicated in each of the structures of T1; T2, X1 and X2.
Each core structure Z in Table 1, and each substituent Tl, T2, Xl and X2 and Tables 5 is represented by a "code" comprising a letter and a number. Each structure of a compound of Formula II can be designated in tabular form by combining the "code" representing each structural moiety using the following syntax:
Z.T1.T2.X1.X2. Thus, for example, Zl.T1A.T2B.X1A.X2A represents the following structure:
Ar\
OH AIk O

Alk-O N N~ N O ~
~ ~{ Alk ~ Alk O Alk õ O
\ Ar In the structures depicted in Tables 1-5, the term "Alk" means a substituted or unsubstituted alkyl or alkylene group, wherein the terms "alkyl"
and "alkylene" are as defined herein. "Alk" means an alkyl group when depicted as monovalent, and an alkylene group when depicted as divalent.

"Het" is a substituted or unsubstituted heterocyclyl or heterocyclylene group, wherein the term "heterocyclyl" is as defined herein, and the term "heterocyclylene" means a heterocyclyl group as defined herein, in which a hydrogen atom has been replaced by an open valence (in analogy to alkylene), thereby defining a divalent heterocyclyl. "Het" is a heterocyclyl when depicted as monovalent, and heterocyclylene when depicted as divalent. "Ar" is a substitute or unsubstituted aryl or arylene group, wherein the term "aryl" is as defined herein, and the term "arylene" means an aryl group as defined herein, in which a hydrogen atom has been replaced by an open valence (in analogy to alkylene), thereby defining a divalent aryl. "Ar" is aryl when depicted as monovalent, and arylene when depicted as divalent. When substituted, "Alk", "Het", and "Ar" can be substituted with any of the substituents defined or exemplified herein. For example, substituents of "Alk" can include ether, halogen, -OH, amide, amine, etc., substituents of "Het" can include alkyl, aryl, carbonyl, -OH, halogen, and substituents of "Ar" can include alkyl, aryl, -OH, halogen, etc., with the proviso that the resulting structure is chemically reasonable, and would provide compounds which are sufficiently stable for formulation in a pharmaceutically acceptable composition.

Table 1: Core Structures Code Core Structure OH ilk O

~ H T2 0 Alk Code Core Structure Z2 X2\
A!k =
OH
T1 N N'O jS O
~ H T2 O AIk Alk OH O =
~ IS~

yN I H , T2 N 0 Alk'-~

Z4 OH X2 '-ilk O
T1 N~
~N H T2 X1 I'll Alk Alk Table 2: Tl Structures Code Tl Structure T1A -O-AIk T1B -O-Het TiC -O-Alk-Het T1D -Alk-NH-C(O)-O-Alk TiE -Het-NH-C(O)-O-Alk T1F -N(Alk)(Het) Table 3: T2 Structures Code T2 Structure T2A -Alk-NH-C(O)-O-Alk T2B -Alk-NH-C(O)-O-Alk-Ar T2C -Alk-NH-C(O)-O-Alk-Het T2D -Alk-Het T2E -0-Het T2F -Alk-NH-C(O)-Alk Table 4: Xl Structures Cod Xl Structure XlA -Ar X1B -Ar-Ar X1C -Ar-Het X1D -Ar-O-Het X1E -Ar-O-Alk-Het X1F -Ar-NH-Het .10 Table 5: X2 Structures Code X2 Structure X2A -Ar X2B -Ar-Ar X2C -Ar-Het X2D -Ar-O-Het X2E -Ar-O-Alk-Het X2F -Ar-NH-Het Table 6: List of Compound Structures of Formula II
Z1.T1A.T2A.X1A.X2A, Z2.T1A.T2A.X1A.X2A, Z3.T1A.T2A.X1A.X2A, Z4.T1A.T2A.XlA.X2A, Z1.T1B.T2A.X1A.X2A, Z2.T1B.T2A.XlA.X2A, Z3.T1B.T2A.X1A.X2A, Z4.T1B.T2A.X1A.X2A, Z1.T1C.T2A.X1A.X2A, Z2.T1C.T2A.XlA.X2A, Z3.T1C.T2A.X1A.X2A, Z4.T1C.T2A.X1A.X2A, Z1.T1D.T2A.X1A.X2A, Z2.T1D.T2A.X1A.X2A, Z3.T1D.T2A.X1A.X2A, Z4.T1D.T2A.X1A.X2A, Z1.T1E.T2A.X1A.X2A, Z2.T1E.T2A.X1A.X2A, Z3.T1E.T2A.X1A.X2A, Z4.T1E.T2A.X1A.X2A, Z1.T1F.T2A.X1A.X2A, Z2.T1F.T2A.X1A.X2A, Z3.T1F.T2A.X1A.X2A, Z4.T1F.T2A.X1A.X2A, Z1.T1A.T2B.X1A.X2A, Z2.T1A.T2B.X1A.X2A, Z3.T1A.T2B.X1A.X2A, Z4.T1A.T2B.X1A.X2A, Z1.T1B.T2B.X1A.X2A, Z2.T1B.T2B.X1A.X2A, Z3.T1B.T2B.X1A.X2A, Z4.T1B.T2B.X1A.X2A, Z1.T1C.T2B.X1A.X2A, Z2.T1C.T2B.X1A.X2A, Z3.T1C.T2B.X1A.X2A, Z4.T1C.T2B.X1A.X2A, Z1.T1D.T2B.X1A.X2A, Z2.T1D.T2B.X1A.X2A, Z3.T1D.T2B.X1A.X2A, Z4.T1D.T2B.X1A.X2A, Z1.T1E.T2B.X1A.X2A, Z2.T1E.T2B.X1A.X2A, Z3.T1E.T2B.X1A.X2A, Z4.TlE.T2B.X1A.X2A, Z1.T1F.T2B.X1A.X2A, Z2.T1F.T2B.X1A.X2A, Z3.T1F.T2B.X1A.X2A, Z4.T1F.T2B.X1A.X2A, Z1.T1A.T2C.X1A.X2A, Z2.T1A.T2C.X1A.X2A, Z3.T1A.T2C.X1A.X2A, Z4.TlA.T2C.X1A.X2A, Z1.T1B.T2C.X1A.X2A, Z2.T1B.T2C.X1A.X2A, Z3.T1B.T2C.X1A.X2A, Z4.T1B.T2C.X1A.X2A, Z1.T1C.T2C.XlA.X2A, Z2.T1C.T2C.X1A.X2A, Z3.T1C.T2C.X1A.X2A, Z4.T1C.T2C.XlA.X2A, Z1.T1D.T2C.X1A.X2A, Z2.T1D.T2C.X1A.X2A, Z3.T1D.T2C.XlA.X2A, Z4.T1D.T2C.X1A.X2A, Z1.T1E.T2C.X1A.X2A, Z2.T1E.T2C.X1A.X2A, Z3.TlE.T2C.X1A.X2A, Z4.T1E.T2C.X1A.X2A, Z1.T1F.T2C.X1A.X2A, Z2.T1F.T2C.X1A.X2A, Z3.T1F.T2C.X1A.X2A, Z4.T1F.T2C.X1A.X2A, Z1.T1A.T2D.X1A.X2A, Z2.T1A.T2D.X1A.X2A, Z3.T1A.T2D.X1A.X2A, Z4.T1A.T2D.X1A.X2A, Z1.T1B.T2D.X1A.X2A, Z2.T1B.T2D.X1A.X2A, Z3.T1B.T2D.X1A.X2A, Z4.T1B.T2D.X1A.X2A, Z1.T1C.T2D.XlA.X2A, Z2.T1C.T2D.X1A.X2A, Z3.T1C.T2D.X1A.X2A, Z4.T1C.T2D.X1A.X2A, Z1.T1D.T2D.X1A.X2A, Z2.T1D.T2D.X1A.X2A, Z3.T1D.T2D.X1A.X2A, Z4.T1D.T2D.X1A.X2A, Z1.T1E.T2D.X1A.X2A, Z2.T1E.T2D.X1A.X2A, Z3.T1E.T2D.XlA.X2A, Z4.T1E.T2D.X1A.X2A, Z1.T1F.T2D.X1A.X2A, Z2.T1F.T2D.X1A.X2A, Z3.T1F.T2D.X1A.X2A, Z4.T1F.T2D.X1A.X2A, Z1.T1A.T2E.X1A.X2A, Z2.T1A.T2E.X1A.X2A, Z3.T1A.T2E.X1A.X2A, Z4.T1A.T2E.X1A.X2A, Z1.T1B.T2E.X1A.X2A, Z2.T1B.T2E.X1A.X2A, Z3.T1B.T2E.X1A.X2A, Z4.T1B.T2E.X1A.X2A, Z1.T1C.T2E.X1A.X2A, Z2.T1C.T2E.X1A.X2A, Z3.T1C.T2E.X1A.X2A, Z4.T1C.T2E.X1A.X2A, Z1.T1D.T2E.X1A.X2A, Z2.T1D.T2E.X1A.X2A, Z3.T1D.T2E.XlA.X2A, Z4.T1D.T2E.X1A.X2A, Z1.T1E.T2E.X1A.X2A, Z2.T1E.T2E.X1A.X2A, Z3.T1E.T2E.X1A.X2A, Z4.T1E.T2E.X1A.X2A, Z1.T1F.T2E.X1A.X2A, Z2.T1F.T2E.X1A.X2A, Z3.T1F.T2E.X1A.X2A, Z4.T1F.T2E.X1A.X2A, Z1.T1A.T2F.X1A.X2A, Z2.T1A.T2F.X1A.X2A, Z3.T1A.T2F.X1A.X2A, Z4.T1A.T2F.X1A.X2A, Z1.T1B.T2F.X1A.X2A, Z2.T1B.T2F.X1A.X2A, Z3.T1B.T2F.X1A.X2A, Z4.T1B.T2F.X1A.X2A, Z1.T1C.T2F.X1A.X2A, Z2.T1C.T2F.X1A.X2A, Z3.T1C.T2F.XlA.X2A, Z4.T1C.T2F.X1A.X2A, Z1.T1D.T2F.X1A.X2A, Z2.T1D.T2F.X1A.X2A, Z3.T1D.T2F.X1A.X2A, Z4.T1D.T2F.X1A.X2A, Z1.T1E.T2F.X1A.X2A, Z2.T1E.T2F.X1A.X2A, Z3.T1E.T2F.X1A.X2A, Z4.T1E.T2F.X1A.X2A, Z1.T1F.T2F.X1A.X2A, Z2.T1F.T2F.X1A.X2A, Z3.T1F.T2F.X1A.X2A, Z4.T1F.T2F.X1A.X2A, Z1.T1A.T2A.X1B.X2A, Z2.T1A.T2A.X1B.X2A, Z3.T1A.T2A.X1B.X2A, Z4.T1A.T2A.X1B.X2A, Z1.T1B.T2A.X1B.X2A, Z2.T1B.T2A.X1B.X2A, Z3.T1B.T2A.X1B.X2A, Z4.T1B.T2A.X1B.X2A, Z1.T1C.T2A.X1B.X2A, Z2.T1C.T2A.X1B.X2A, Z3.T1C.T2A.X1B.X2A, Z4.T1C.T2A.X1B.X2A, Zl.T1D.T2A.X1B.X2A, Z2.T1D.T2A.X1B.X2A, Z3.T1D.T2A.X1B.X2A, Z4.T1D.T2A.X1B.X2A, Z1.T1E.T2A.X1B.X2A, Z2.T1E.T2A.X1B.X2A, Z3.T1E.T2A.X1B.X2A, Z4.T1E.T2A.X1B.X2A, Z1.T1F.T2A.X1B.X2A, Z2.T1F.T2A.X1B.X2A, Z3.T1F.T2A.X1B.X2A, Z4.T1F.T2A.X1B.X2A, Z1.T1A.T2B.X1B.X2A, Z2.T1A.T2B.X1B.X2A, Z3.T1A.T2B.X1B.X2A, Z4.T1A.T2B.X1B.X2A, Z1.T1B.T2B.X1B.X2A, Z2.T1B.T2B.X1B.X2A, Z3.T1B.T2B.X1B.X2A, Z4.T1B.T2B.X1B.X2A, Z1.T1C.T2B.X1B.X2A, Z2.T1C.T2B.X1B.X2A, Z3.T1C.T2B.X1B.X2A, Z4.T1C.T2B.X1B.X2A, Z1.T1D.T2B.X1B.X2A, Z2.T1D.T2B.X1B.X2A, Z3.T1D.T2B.X1B.X2A, Z4.T1D.T2B.X1B.X2A, Z1.T1E.T2B.X1B.X2A, Z2.T1E.T2B.X1B.X2A, Z3.T1E.T2B.X1B.X2A, Z4.T1E.T2B.X1B.X2A, Z1.T1F.T2B.X1B.X2A, Z2.T1F.T2B.X1B.X2A, Z3.T1F.T2B.X1B.X2A, Z4.T1F.T2B.X1B.X2A, Z1.T1A.T2C.X1B.X2A, Z2.T1A.T2C.X1B.X2A, Z3.T1A.T2C.X1B.X2A, Z4.T1A.T2C.X1B.X2A, Z1.T1B.T2C.X1B.X2A, Z2.T1B.T2C.X1B.X2A, Z3.T1B.T2C.X1B.X2A, Z4.T1B.T2C.X1B.X2A, Z1.T1C.T2C.X1B.X2A, Z2.T1C.T2C.X1B.X2A, Z3.T1C.T2C.X1B.X2A, Z4.T1C.T2C.X1B.X2A, Z1.T1D.T2C.X1B.X2A, Z2.T1D.T2C.X1B.X2A, Z3.T1D.T2C.X1B.X2A, Z4.T1D.T2C.X1B.X2A, Z1.T1E.T2C.X1B.X2A, Z2.T1E.T2C.X1B.X2A, Z3.T1E.T2C.X1B.X2A, Z4.T1E.T2C.X1B.X2A, Zl.T1F.T2C.X1B.X2A, Z2.T1F.T2C.X1B.X2A, Z3.T1F.T2C.X1B.X2A, Z4.T1F.T2C.X1B.X2A, Z1.T1A.T2D.X1B.X2A, Z2.T1A.T2D.X1B.X2A, Z3.T1A.T2D.X1B:X2A, Z4.T1A.T2D.X1B.X2A, Z1.T1B.T2D.X1B.X2A, Z2.T1B.T2D.X1B.X2A, Z3.T1B.T2D.X1B.X2A, Z4.T1B.T2D.X1B.X2A, Z1.T1C.T2D.X1B.X2A, Z2.T1C.T2D.X1B.X2A, Z3.T1C.T2D.X1B.X2A, Z4.T1C.T2D.X1B.X2A, Z1.T1D:T2D.X1B.X2A, Z2.T1D.T2D.X1B.X2A, Z3.T1D.T2D.X1B.X2A, Z4.T1D.T2D.X1B.X2A, Z1.T1E.T2D.X1B.X2A, Z2.T1E.T2D.X1B.X2A, Z3.T1E.T2D.X1B.X2A, Z4.T1E.T2D.X1B.X2A, Z1.T1F.T2D.X1B.X2A, Z2.T1F.T2D.X1B.X2A, Z3.T1F.T2D.X1B.X2A, Z4.T1F.T2D.X1B.X2A, Z1.T1A.T2E.X1B.X2A, Z2.T1A.T2E.X1B.X2A, Z3.T1A.T2E.X1B.X2A, Z4.T1A.T2E.X1B.X2A, Z1.T1B.T2E.X1B.X2A, Z2.T1B.T2E.X1B.X2A, Z3.T1B:T2E.X1B.X2A, Z4.T1B.T2E.X1B.X2A, Z1.T1C.T2E.X1B.X2A, Z2.T1C.T2E.X1B.X2A, Z3.T1C.T2E.X1B.X2A, Z4.T1C.T2E.X1B:X2A, Z1.T1D.T2E.X1B.X2A, Z2.T1D.T2E.X1B.X2A, Z3.T1D.T2E.X1B.X2A, Z4.T1D.T2E.X1B.X2A, Z1.T1E.T2E.X1B.X2A, Z2.T1E.T2E.X1B.X2A, Z3.T1E.T2E.X1B.X2A, Z4.T1E.T2E.X1B.X2A, Zi.T1F.T2E.X1B.X2A, Z2.T1F.T2E.X1B.X2A, Z3.T1F.T2E.X1B.X2A, Z4.T1F.T2E.X1B.X2A, Z1.T1A.T2F.X1B.X2A, Z2.T1A.T2F.X1B.X2A, Z3.T1A.T2F.X1B.X2A, Z4.T1A.T2F.X1B.X2A, Z1.T1B.T2F.X1B.X2A, Z2.T1B.T2F.X1B.X2A, Z3.T1B.T2F.X1B.X2A, Z4.T1B.T2F.X1B.X2A, Z1.T1C.T2F.X1B.X2A, Z2.T1C.T2F.X1B.X2A, Z3.T1C.T2F.X1B.X2A, Z4.T1C.T2F.X1B.X2A, Z1.T1D.T2F.X1B.X2A, Z2.T1D.T2F.X1B.X2A, Z3.T1D.T2F.X1B.X2A, Z4.T1D.T2F.X1B.X2A, Z1.T1E.T2F.X1B.X2A, Z2.T1E.T2F.X1B.X2A, Z3.T1E.T2F.X1B.X2A, Z4.T1E.T2F.X1B.X2A, Z1.T1F.T2F.X1B.X2A, Z2.T1F.T2F.X1B.X2A, Z3.T1F.T2F.X1B.X2A, Z4.T1F.T2F.X1B.X2A, Z1.T1A.T2A.X1C.X2A, Z2.T1A.T2A.X1C.X2A, Z3.T1A.T2A.X1C.X2A, Z4.T1A.T2A.X1C.X2A, Z1.T1B.T2A.X1C.X2A, Z2.T1B.T2A.X1C.X2A, Z3.T1B.T2A.X1C.X2A, Z4.T1B.T2A.X1C.X2A, Z1.T1C.T2A.X1C.X2A,.
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Z3.T1A.T2E.X1C.X2B, Z4.T1A.T2E.X1C.X2B, Z1.T1B.T2E.X1C.X2B, Z2.T1B.T2E.X1C.X2B, Z3.T1B.T2E.X1C.X2B, Z4.T1B.T2E.X1C.X2B, Z1.T1C.T2E.X1C.X2B, Z2.T1C.T2E.X1C.X2B, Z3.T1C.T2E.X1C.X2B, Z4.T1C.T2E.X1C.X2B, Z1.T1D.T2E.X1C.X2B, Z2.T1D.T2E.X1C.X2B, Z3.T1D.T2E.X1C.X2B, Z4.T1D.T2E.X1C.X2B, Z1.T1E.T2E.X1C.X2B, Z2.T1E.T2E.X1C.X2B, Z3.T1E.T2E.X1C.X2B,.Z4.T1E.T2E.X1C.X2B, Z1.T1F.T2E.X1C.X2B, Z2.T1F.T2E.X1C.X2B, Z3.T1F.T2E.X1C.X2B, Z4.T1F.T2E.X1C.X2B, Z1.T1A.T2F.X1C.X2B, Z2.T1A.T2F.X1C.X2B, Z3.T1A.T2F.X1C.X2B, Z4.T1A.T2F.X1C.X2B, Z1.T1B.T2F.X1C.X2B, Z2.T1B.T2F.X1C.X2B, Z3.T1B.T2F.X1C.X2B, Z4.T1B.T2F.X1C.X2B, Z1.T1C.T2F.X1C.X2B, Z2.T1C.T2F.X1C.X2B, Z3.T1C.T2F.X1C.X2B, Z4.T1C.T2F.X1C.X2B, Z1.T1D.T2F.X1C.X2B, Z2.T1D.T2F.X1C.X2B, Z3.T1D.T2F.X1C.X2B, Z4.T1D.T2F.X1C.X2B, Z1.T1E.T2F.X1C.X2B, Z2.T1E.T2F.X1C.X2B, Z3.T1E.T2F.X1C.X2B, Z4.T1E.T2F.X1C.X2B, Z1.T1F.T2F.X1C.X2B, Z2.T1F.T2F.X1C.X2B, Z3.T1F.T2F.X1C.X2B, Z4.T1F.T2F.X1C.X2B, Z1.T1A.T2A.X1D.X2B, Z2.T1A.T2A.X1D.X2B, Z3.T1A.T2A.X1D.X2B, Z4.T1A.T2A.X1D.X2B, Z1.T1B.T2A.X1D.X2B, Z2.T1B.T2A.X1D.X2B, Z3.T1B.T2A.X1D.X2B, Z4.T1B.T2A.X1D.X2B, Z1.T1C.T2A.X1D.X2B, Z2.T1C.T2A.X1D.X2B, Z3.T1C.T2A.X1D.X2B, Z4.T1C.T2A.X1D.X2B, Z1.T1D.T2A.X1D.X2B, Z2.T1D.T2A.X1D.X2B, Z3.T1D.T2A.X1D.X2B, Z4.T1D.T2A.X1D.X2B, Z1.T1E.T2A.X1D.X2B, Z2.T1E.T2A.X1D.X2B, Z3.T1E.T2A.X1D.X2B, Z4.T1E.T2A.X1D.X2B, Z1.T1F.T2A.X1D.X2B, Z2.T1F.T2A_X1D.X2B, Z3.T1F.T2A.X1D.X2B, Z4.T1F.T2A.X1D.X2B, Z1.T1A.T2B.X1D.X2B, Z2.T1A.T2B.X1D.X2B, Z3.T1A.T2B.X1D.X2B, Z4.T1A.T2B.X1D.X2B, Z1.T1B.T2B.X1D.X2B, Z2.T1B.T2B.X1D.X2B, Z3.T1B.T2B.X1D.X2B, Z4.T1B.T2B.X1D.X2B, Z1.T1C.T2B.X1D.X2B, Z2.T1C.T2B.X1D.X2B, Z3.T1C.T2B.X1D.X2B, Z4.T1C.T2B.X1D.X2B, Z1.T1D.T2B.X1D.X2B, Z2.T1D.T2B.X1D.X2B, Z3.T1D.T2B.X1D.X2B, Z4.T1D.T2B.X1D.X2B, Z1.T1E.T2B.X1D.X2B, Z2.T1E.T2B.X1D.X2B, Z3.T1E.T2B.X1D.X2B, Z4.T1E.T2B.X1D.X2B, Z1.T1F.T2B.X1D.X2B, Z2.T1F.T2B.X1D.X2B, Z3.T1F.T2B.X1D.X2B, Z4.T1F.T2B.X1D.X2B, Z1.T1A.T2C.X1D.X2B, Z2.T1A.T2C.X1D.X2B, Z3.T1A.T2C.X1D.X2B, Z4.T1A.T2C.X1D.X2B, Z1.T1B.T2C.X1D.X2B, Z2.T1B.T2C.X1D.X2B, Z3.T1B.T2C.X1D.X2B, Z4.T1B.T2C.X1D.X2B, Z1.T1C.T2C.X1D.X2B, Z2.T1C.T2C.X1D.X2B, Z3.T1C.T2C.X1D.X2B, Z4.T1C.T2C.X1D.X2B, Z1.T1D.T2C.X1D.X2B, Z2.T1D.T2C.X1D.X2B, Z3.T1D.T2C.X1D.X2B, Z4.T1D.T2C.X1D.X2B, Z1.T1E.T2C.X1D.X2B, Z2.T1E.T2C.X1D.X2B, Z3.T1E.T2C.X1D.X2B, Z4.T1E.T2C.X1D.X2B, Z1.T1F.T2C.X1D.X2B, Z2.T1F.T2C.X1D.X2B, Z3.T1F.T2C.X1D.X2B, Z4.T1F.T2C.X1D.X2B, Z1.T1A.T2D.X1D.X2B, Z2.T1A.T2D.X1D.X2B, Z3.T1A.T2D.X1D.X2B, Z4.T1A.T2D.X1D.X2B, Z1.T1B.T2D.X1D.X2B, Z2.T1B.T2D.X1D.X2B, Z3.T1B.T2D.X1D.X2B, Z4.T1B.T2D.X1D.X2B, Z1.T1C.T2D.X1D.X2B, Z2.T1C.T2D.X1D.X2B, Z3.T1C.T2D.X1D.X2B, Z4.T1C.T2D.X1D.X2B, Z1.T1D.T2D.X1D.X2B, Z2.T1D.T2D.X1D.X2B, Z3.T1D.T2D.X1D.X2B, Z4.T1D.T2D.X1D.X2B, Z1.T1E.T2D.X1D.X2B, Z2.T1E.T2D.X1D.X2B, Z3.T1E.T2D.X1D.X2B, Z4.T1E.T2D.X1D.X2B, Z1.T1F.T2D.X1D.X2B, Z2.T1F.T2D.X1D.X2B, Z3.T1F.T2D.X1D.X2B, Z4.T1F.T2D.X1D.X2B, Z1.T1A.T2E.X1D.X2B, Z2.T1A.T2E.X1D.X2B, Z3.T1A.T2E.X1D.X2B, Z4.T1A.T2E.X1D.X2B, Z1.T1B.T2E.X1D.X2B, Z2.T1B.T2E.X1D.X2B, Z3.T1B.T2E.X1D.X2B, Z4.T1B.T2E.X1D.X2B, Z1.T1C.T2E.X1D.X2B, Z2.T1C.T2E.X1D.X2B, Z3.T1C.T2E.X1D.X2B, Z4.T1C.T2E.X1D.X2B, Zi.T1D.T2E.X1D.X2B, Z2.T1D.T2E.X1D.X2B, Z3.T1D.T2E.X1D.X2B, Z4.T1D.T2E.X1D.X2B, Z1.T1E.T2E.X1D.X2B, Z2.T1E.T2E.X1D.X2B, Z3.T1E.T2E.X1D.X2B, Z4.T1E.T2E.X1D.X2B, Z1.T1F.T2E.X1D.X2B, Z2.T1F.T2E.X1D.X2B, Z3.T1F.T2E.X1D.X2B, Z4.T1F.T2E.X1D.X2B, Z1.T1A.T2F.X1D.X2B, Z2.T1A.T2F.X1D.X2B, Z3.T1A.T2F.X1D.X2B, Z4.T1A.T2F.X1D.X2B, Z1.T1B.T2F.X1D.X2B, Z2.T1B.T2F.X1D.X2B, Z3.T1B.T2F.X1D.X2B, Z4.T1B.T2F.X1D.X2B, Z1.T1C.T2F.X1D.X2B, Z2.T1C.T2F.X1D.X2B, Z3.T1C.T2F.X1D.X2B, Z4.T1C.T2F.X1D.X2B, Z1.T1D.T2F.X1D.X2B, Z2.T1D.T2F.X1D.X2B, Z3.T1D.T2F.X1D.X2B, Z4.T1D.T2F.X1D.X2B, Z1.T1E.T2F.X1D.X2B, Z2.T1E.T2F.X1D.X2B, Z3.T1E.T2F.X1D.X2B, Z4.T1E.T2F.X1D.X2B, Z1.T1F.T2F.X1D.X2B, Z2.T1F.T2F.X1D.X2B, Z3.T1F.T2F.X1D.X2B, Z4.T1F.T2F.X1D.X2B, Z1.T1A.T2A.X1E.X2B, Z2.T1A.T2A.X1E.X2B, Z3.TlA.T2A.X1E.X2B, Z4.T1A.T2A.X1E.X2B, Z1.T1B.T2A.X1E.X2B, Z2.T1B.T2A.X1E.X2B, Z3.T1B.T2A.X1E.X2B, Z4.T1B.T2A.X1E.X2B, Z1.T1C.T2A.X1E.X2B, Z2.T1C.T2A.X1E.X2B, Z3.T1C.T2A.X1E.X2B, Z4.T1C.T2A.X1E.X2B, Z1.T1D.T2A.X1E.X2B, Z2.T1D.T2A.X1E.X2B, Z3.T1D.T2A.X1E.X2B, Z4.T1D.T2A.XlE.X2B, Z1.T1E.T2A.X1E.X2B, Z2.T1E.T2A.X1E.X2B, Z3.T1E.T2A.X1E.X2B, Z4.T1E.T2A.X1E.X2B, Z1.T1F.T2A.X1E.X2B, Z2.T1F.T2A.X1E.X2B, Z3.T1F.T2A.X1E.X2B, Z4.T1F.T2A.X1E.X2B, Z1.T1A.T2B.X1E.X2B, Z2.T1A.T2B.X1E.X2B, Z3.T1A.T2B.X1E.X2B, Z4.T1A.T2B.X1E.X2B, Z1.T1B.T2B.X1E.X2B, Z2.T1B.T2B.X1E.X2B, Z3.T1B.T2B.X1E.X2B, Z4.T1B.T2B.X1E.X2B, Z1.T1C.T2B.X1E.X2B, Z2.T1C.T2B.X1E.X2B, Z3.T1C.T2B.XlE.X2B, Z4.T1C.T2B.X1E.X2B, Z1.T1D.T2B.X1E.X2B, Z2.T1D.T2B.X1E.X2B, Z3.T1D.T2B.X1E.X2B, Z4.T1D.T2B.X1E.X2B, Z1.T1E.T2B.X1E.X2B, Z2.T1E.T2B.X1E.X2B, Z3.T1E.T2B.X1E.X2B, Z4.T1E.T2B.X1E.X2B, Z1.T1F.T2B.X1E.X2B, Z2.T1F.T2B.X1E.X2B, Z3.T1F.T2B.X1E.X2B, Z4.T1F.T2B.X1E.X2B, Z1.T1A.T2C.X1E.X2B, Z2.T1A.T2C.X1E.X2B, Z3.T1A.T2C.X1E.X2B, Z4.T1A.T2C.X1E.X2B, Z1.T1B.T2C:X1E.X2B, Z2.T1B.T2C.X1E.X2B;
Z3.T1B.T2C.X1E.X2B, Z4.T1B.T2C.X1E.X2B, Z1.T1C.T2C.X1E.X2B, Z2.T1C.T2C.X1E.X2B, Z3.T1C.T2C.X1E.X2B, Z4.T1C.T2C.X1E.X2B, Z1.T1D.T2C.XlE.X2B, Z2.T1D.T2C.X1E.X2B, Z3.T1D.T2C.X1E.X2B, Z4.T1D.T2C.XlE.X2B, Z1.T1E.T2C.X1E.X2B, Z2.T1E.T2C.X1E.X2B, Z3.T1E.T2C.X1E.X2B, Z4.T1E.T2C.X1E.X2B, Z1.T1F.T2C.X1E.X2B, Z2.T1F.T2C.X1E.X2B, Z3.T1F.T2C.X1E.X2B, Z4.T1F.T2C.X1E.X2B, Z1.T1A.T2D.X1E.X2B, Z2.T1A.T2D.XlE.X2B, Z3.T1A.T2D.X1E.X2B, Z4.T1A.T2D.X1E.X2B, Z1.T1B.T2D.X1E.X2B, Z2.T1B.T2D.X1E.X2B, Z3.T1B.T2D.X1E.X2B, Z4.T1B.T2D.X1E.X2B, Z1.T1C.T2D.X1E.X2B, Z2.T1C.T2D.X1E.X2B, Z3.T1C.T2D.X1E.X2B, Z4.T1C.T2D.X1E.X2B;
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Z1.T1A.T2B.X1A.X2C, Z2.T1A.T2B.X1A.X2C, Z3.T1A.T2B.X1A.X2C, Z4.T1A.T2B.X1A.X2C, Z1.T1B.T2B.X1A.X2C, Z2.T1B.T2B.X1A.X2C, Z3.T1B.T2B.X1A.X2C, Z4.T1B.T2B.X1A.X2C, Zl.T1C.T2B.X1A.X2C, Z2.T1C.T2B.X1A.X2C, Z3.T1C.T2B.X1A.X2C, Z4.T1C.T2B.X1A.X2C, Z1.T1D.T2B.X1A.X2C, Z2.T1D.T2B.X1A.X2C, Z3.T1D.T2B.X1A.X2C, Z4.T1D.T2B.X1A.X2C, Z1.T1E.T2B.X1A.X2C, Z2.T1E.T2B.X1A.X2C, Z3.T1E.T2B.X1A.X2C, Z4.T1E.T2B.X1A.X2C, Z1.T1F.T2B.X1A.X2C, Z2.T1F.T2B.X1A.X2C, Z3.T1F.T2B.X1A.X2C, Z4.T1F.T2B.X1A.X2C, Z1.T1A.T2C.X1A.X2C, Z2.T1A.T2C.X1A.X2C, Z3.T1A.T2C.X1A.X2C, Z4.T1A.T2C.X1A.X2C, Z1.T1B.T2C.X1A.X2C, Z2.T1B.T2C.X1A.X2C, Z3.T1B.T2C.X1A.X2C, Z4.T1B.T2C.X1A.X2C; Z1.T1C.T2C.X1A.X2C, Z2.T1C.T2C.X1A.X2C, Z3.T1C.T2C.X1A.X2C, Z4.T1C.T2C.X1A.X2C, Z1.T1D.T2C.X1A.X2C, Z2.T1D.T2C.X1A.X2C, Z3.T1D.T2C.X1A.X2C, Z4.T1D.T2C.X1A.X2C, Z1.T1E.T2C.X1A.X2C, Z2.T1E.T2C.X1A.X2C, Z3.T1E.T2C.X1A.X2C, Z4.T1E.T2C.X1A.X2C, Z1.T1F.T2C.X1A.X2C, Z2.T1F.T2C.X1A.X2C, Z3.T1F.T2C.X1A.X2C, Z4.T1F.T2C.X1A.X2C, Z1.T1A.T2D.X1A.X2C, Z2.T1A.T2D.X1A.X2C, Z3.T1A.T2D.X1A.X2C, Z4.T1A.T2D.X1A.X2C, Z1.T1B.T2D.X1A.X2C, Z2.T1B.T2D.X1A.X2C, Z3.T1B.T2D.X1A.X2C, Z4.T1B.T2D.X1A.X2C, Z1.T1C.T2D.X1A.X2C, Z2.T1C.T2D.X1A.X2C, Z3.T1C.T2D.X1A.X2C, Z4.T1C.T2D.X1A.X2C, Z1.T1D.T2D.X1A.X2C, Z2.T1D.T2D.X1A.X2C, Z3.T1D.T2D.X1A.X2C, Z4.T1D.T2D.X1A.X2C, Z1.T1E.T2D.X1A.X2C, Z2.T1E.T2D.X1A.X2C, Z3.T1E.T2D.X1A.X2C, Z4.T1E.T2D.X1A.X2C, Z1.T1F.T2D.X1A.X2C, Z2.T1F.T2D.X1A.X2C, Z3.T1F.T2D.X1A.X2C, Z4.T1F.T2D.X1A.X2C, Z1.T1A.T2E.X1A.X2C, Z2.TlA.T2E.X1A.X2C, Z3.TlA.T2E.X1A.X2C, Z4.T1A.T2E.X1A.X2C, Z1.T1B.T2E.X1A.X2C, Z2.T1B.T2E.X1A.X2C, Z3.T1B.T2E.X1A.X2C, Z4.T1B.T2E.X1A.X2C, Z1.T1C.T2E.X1A.X2C, Z2.T1C.T2E.X1A.X2C, Z3.T1C.T2E.X1A.X2C; Z4.T1C.T2E.X1A.X2C, Z1.T1D.T2E.X1A.X2C, Z2.T1D.T2E.X1A.X2C, Z3.T1D.T2E.X1A.X2C, Z4.T1D.T2E.X1A.X2C, Z1.T1E_T2E.X1A.X2C, Z2.T1E.T2E.X1A.X2C, Z3.T1E.T2E.X1A.X2C, Z4.T1E.T2E.X1A.X2C, Z1.T1F.T2E.X1A.X2C, Z2.T1F.T2E.X1A.X2C, Z3.T1F.T2E.X1A.X2C, Z4.T1F.T2E.X1A.X2C, Z1.T1A.T2F.X1A.X2C, Z2.T1A.T2F.X1A.X2C, Z3.T1A.T2F.X1A.X2C, Z4.T1A.T2F.X1A.X2C, Z1.T1B.T2F.X1A.X2C, Z2.T1B.T2F.X1A.X2C, Z3.T1B.T2F.X1A.X2C, Z4.T1B.T2F.X1A.X2C, Z1.T1C.T2F.X1A.X2C, Z2.T1C.T2F.X1A.X2C, Z3.T1C.T2F.X1A.X2C, Z4.T1C.T2F.X1A.X2C, Z1.T1D.T2F.X1A.X2C, Z2.T1D.T2F.X1A.X2C, Z3.T1D.T2F.X1A.X2C, Z4.T1D.T2F.X1A.X2C, Z1.T1E.T2F.X1A.X2C, Z2.T1E.T2F.X1A.X2C, Z3.T1E.T2F.X1A.X2C, Z4.T1E.T2F.X1A.X2C, Z1.T1F.T2F.X1A.X2C, Z2.T1F.T2F.X1A.X2C, Z3.T1F.T2F.X1A.X2C, Z4.T1F.T2F.X1A.X2C, Z1.T1A.T2A.X1B.X2C, Z2.T1A.T2A.X1B.X2C, Z3.T1A.T2A.X1B.X2C, Z4.T1A.T2A.X1B.X2C, Z1.T1B.T2A.X1B.X2C, Z2.T1B.T2A.X1B.X2C, Z3.T1B.T2A.X1B.X2C, Z4.T1B.T2A.X1B.X2C, Z1.T1C.T2A.X1B.X2C, Z2.T1C.T2A.X1B.X2C, Z3.T1C.T2A.X1B.X2C, Z4.T1C.T2A.X1B.X2C, Z1.T1D.T2A.X1B.X2C, Z2.T1D.T2A.X1B.X2C, Z3.T1D.T2A.X1B.X2C, Z4.T1D.T2A.X1B.X2C, Z1.T1E.T2A.X1B.X2C, Z2.T1E.T2A.X1B.X2C, Z3.T1E.T2A.X1B.X2C, Z4.T1E.T2A.X1B.X2C, Z1.T1F.T2A.X1B.X2C, Z2.T1F.T2A.X1B.X2C, Z3.T1F.T2A.X1B.X2C, Z4.T1F.T2A.X1B.X2C, Z1.T1A.T2B.X1B.X2C, Z2.T1A.T2B.X1B.X2C, Z3.T1A.T2B.X1B.X2C, Z4.T1A.T2B.X1B.X2C, Z1.T1B.T2B.X1B.X2C, Z2.T1B.T2B.X1B.X2C, Z3.TIB.T2B.X1B.X2C, Z4.T1B.T2B.X1B.X2C, Z1.T1C.T2B.X1B.X2C, Z2.T1C.T2B.X1B.X2C, Z3.T1C.T2B.X1B.X2C, Z4.T1C.T2B.X1B.X2C, Z1.T1D.T2B.X1B.X2C, Z2.T1D.T2B.X1B.X2C, Z3.T1D.T2B.X1B.X2C, Z4.T1D.T2B.X1B.X2C, Z1.T1E.T2B.X1B.X2C, Z2.T1E.T2B.X1B.X2C, Z3.T1E.T2B.X1B.X2C, Z4.T1E.T2B.X1B.X2C, Z1.T1F.T2B.X1B.X2C, Z2.T1F.T2B.X1B.X2C, Z3.T1F.T2B.X1B.X2C, Z4.T1F.T2B.X1B.X2C, Z1.T1A.T2C.X1B.X2C, Z2.T1A.T2C.X1B.X2C, Z3.T1A.T2C.X1B.X2C, Z4.T1A.T2C.X1B.X2C, Z1.T1B.T2C.X1B.X2C, Z2.T1B.T2C.X1B.X2C, Z3.T1B.T2C.X1B.X2C, Z4.T1B.T2C.X1B.X2C, Z1.T1C.T2C.X1B.X2C, Z2.T1C.T2C.X1B.X2C, Z3.T1C.T2C.X1B.X2C, Z4.T1C_T2C.X1B.X2C, Z1.T1D.T2C.X1B.X2C, Z2.T1D.T2C.X1B.X2C, Z3.T1D.T2C.X1B.X2C, Z4.T1D.T2C.X1B.X2C, Z1.T1E.T2C.X1B.X2C, Z2.T1E.T2C.X1B.X2C, Z3.T1E.T2C.X1B.X2C, Z4.T2E.T2C.X1B.X2C, Z1.T1F.T2C.X1B.X2C, Z2.T1F.T2C.X1B.X2C, Z3.T1F.T2C.X1B.X2C, Z4.T1F.T2C.X1B.X2C, Z1.T1A.T2D.X1B:X2C, Z2.T1A.T2D.X1B.X2C, Z3.TlA.T2D.X1B.X2C, Z4.T1A.T2D.X1B.X2C, Z1.T1B.T2D.X1B.X2C, Z2.T1B.T2D.X1B.X2C, Z3.T1B.T2D.X1B.X2C, Z4.T1B.T2D.X1B.X2C, Z1.T1C.T2D.X1B.X2C, Z2.T1C.T2D.X1B.X2C, Z3.T1C.T2D.X1B.X2C, Z4.T1C.T2D.X1B.X2C, Zl.T1D.T2D.X1B.X2C, Z2.T1D.T2D.X1B.X2C, Z3.T1D.T2D.X1B.X2C, Z4.T1D.T2D.X1B.X2C, Z1.T1E.T2D.X1B.X2C, Z2.T1E.T2D.X1B.X2C, Z3.T1E.T2D.X1B.X2C, Z4.T1E.T2D.X1B.X2C, Z1.T1F.T2D.X1B.X2C, Z2.T1F.T2D.X1B.X2C, Z3.T1F.T2D.X1B.X2C, Z4.T1F.T2D.X1B.X2C, Z1.T1A.T2E.X1B.X2C, Z2.T1A.T2E.X1B.X2C, Z3.T1A.T2E.X1B.X2C, Z4.T1A.T2E.X1B.X2C, Z1.T1B.T2E.X1B.X2C, Z2.T1B.T2E.X1B.X2C, Z3:T1B.T2E.X1B.X2C, Z4.T1B.T2E.X1B.X2C, Z1.T1C.T2E.X1B.X2C, Z2.T1C.T2E.X1B.X2C, Z3.T1C.T2E.X1B.X2C, Z4.T1C.T2E.X1B.X2C, Z1.T1D.T2E.X1B.X2C, Z2.T1D.T2E.X1B.X2C, Z3.T1D.T2E.X1B.X2C, Z4.T1D.T2E.X1B.X2C, Z1.T1E.T2E.X1B.X2C, Z2.T1E.T2E.X1B.X2C, Z3.T1E.T2E.X1B.X2C, Z4.T1E.T2E.X1B.X2C, Z1.T1F.T2E.X1B.X2C, Z2.T1F.T2E.X1B.X2C, Z3.T1F.T2E.X1B.X2C, Z4.T1F.T2E.X1B.X2C, Zi.T1A.T2F.X1B.X2C, Z2.T1A.T2F.X1B.X2C, Z3.T1A.T2F.X1B.X2C;
Z4.T1A.T2F.X1B.X2C, Z1.T1B.T2F.X1B.X2C, Z2.T1B.T2F.X1B.X2C, Z3.T1B.T2F.X1B.X2C, Z4.T1B.T2F.X1B.X2C, Zl.T1C.T2F.X1B.X2C, Z2.T1C.T2F.X1B.X2C, Z3.T1C.T2F.X1B.X2C, Z4.T1C.T2F.X1B.X2C, Z1.T1D.T2F.X1B.X2C, Z2.T1D.T2F.X1B.X2C, Z3.T1D.T2F.X1B.X2C, Z4.T1D.T2F.X1B.X2C, Z1.T1E.T2F.X1B.X2C, Z2.T1E.T2F.X1B.X2C, Z3.TlE.T2F.X1B.X2C, Z4.T1E.T2F.X1B.X2C, Zl.T1F.T2F.X1B.X2C, Z2.T1F.T2F.X1B.X2C, Z3.T1F.T2F.X1B.X2C, Z4.T1F.T2F.X1B.X2C, Z1.T1A.T2A.X1C.X2C, Z2.T1A.T2A.X1C.X2C, Z3.T1A.T2A.X1C.X2C, Z4.T1A.T2A.X1C.X2C, Z1.T1B.T2A.X1C.X2C, Z2.T1B.T2A.X1C.X2C, Z3.T1B.T2A.X1C.X2C, Z4.T1B.T2A.X1C.X2C, Z1.T1C.T2A.X1C.X2C, Z2.T1C.T2A.X1C.X2C, Z3.T1C.T2A.X1C.X2C, Z4.T1C.T2A.X1C.X2C, Z1.T1D.T2A.X1C.X2C, Z2.T1D.T2A.X1C.X2C, Z3.T1D.T2A.X1C.X2C, Z4.T1D.T2A.X1C.X2C, Z1.T1E.T2A.X1C.X2C, Z2.T1E.T2A.X1C.X2C, Z3.T1E.T2A.X1C.X2C, Z4.T1E.T2A.X1C.X2C, Z1.T1F.T2A.X1C.X2C, Z2.T1F.T2A.X1C.X2C, Z3.T1F.T2A.X1C.X2C, Z4.T1F.T2A.X1C.X2C, Z1.T1A.T2B.X1C.X2C, Z2.T1A.T2B.X1C.X2C, Z3.T1A.T2B.X1C.X2C, Z4.T1A.T2B.X1C.X2C, Z1.T1B.T2B.X1C.X2C, 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Z4.T1D.T2C.X1B.X2E, Z1.T1E.T2C.X1B.X2E, Z2.T1E.T2C.X1B.X2E, Z3.T1E.T2C.X1B.X2E, Z4.T1E.T2C.X1B.X2E, Z1.T1F.T2C.X1B.X2E, Z2.T1F.T2C.X1B.X2E, Z3.T1F.T2C.X1B.X2E, Z4.T1F.T2C.X1B.X2E, Z1.TlA.T2D.X1B.X2E, Z2.T1A.T2D.X1B.X2E, Z3.T1A.T2D.X1B.X2E, Z4.T1A.T2D.X1B.X2E, Z1.T1B.T2D.X1B.X2E, Z2.T1B.T2D.X1B.X2E, Z3.T1B.T2D.X1B.X2E, Z4.T1B.T2D.X1B.X2E, Z1.T1C.T2D.X1B.X2E, Z2.T1C.T2D.X1B.X2E, Z3.T1C.T2D.X1B.X2E, Z4.T1C.T2D.X1B.X2E, Z1.T1D.T2D.X1B.X2E, Z2.T1D.T2D.X1B.X2E, Z3.T1D.T2D.X1B.X2E, Z4.T1D.T2D.X1B.X2E, Z1.T1E.T2D.X1B.X2E, Z2.T1E.T2D.X1B.X2E, Z3.T1E.T2D.X1B.X2E, Z4.T1E.T2D.X1B.X2E, Z1.T1F.T2D.X1B.X2E, Z2.T1F.T2D.X1B.X2E, Z3.T1F.T2D.X1B.X2E, Z4.T1F.T2D.X1B.X2E, Z1.T1A.T2E.X1B.X2E, Z2.T1A.T2E.X1B.X2E, Z3.T1A.T2E.X1B.X2E, Z4.T1A.T2E.X1B.X2E, Z1.T1B.T2E.X1B.X2E, Z2.T1B.T2E.X1B.X2E, Z3.T1B.T2E.X1B.X2E, Z4.T1B.T2E.X1B.X2E, Z1.T1C.T2E.X1B.X2E, Z2.T1C.T2E.X1B.X2E, Z3.T1C.T2E.X1B.X2E, Z4.T1C.T2E.X1B.X2E, Z1.T1D.T2E.X1B.X2E, Z2.T1D.T2E.X1B.X2E, Z3.T1D.T2E.X1B.X2E, Z4.T1D.T2E.X1B.X2E, Zl.T1E.T2E.X1B.X2E, 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Z1.T1E.T2A.X1E.X2F, Z2.T1E.T2A.X1E.X2F, Z3.T1E.T2A.X1E.X2F, Z4.T1E.T2A.X1E.X2F, Z1.T1F.T2A.X1E.X2F, Z2.T1F.T2A.X1E.X2F, Z3.T1F.T2A.X1E.X2F, Z4.T1F.T2A.X1E.X2F, Z1.T1A.T2B.X1E.X2F, Z2.T1A.T2B.X1E.X2F, Z3.T1A.T2B.X1E.X2F, Z4.T1A.T2B.X1E.X2F, Z1.T1B.T2B.X1E.X2F, Z2.T1B.T2B.X1E.X2F, Z3.T1B.T2B.X1E.X2F, Z4.T1B.T2B.X1E.X2F, Z1.T1C.T2B.X1E.X2F, Z2.T1C.T2B.X1E.X2F, Z3.T1C.T2B.X1E.X2F, Z4.T1C.T2B.X1E.X2F, Z1.T1D.T2B.X1E.X2F, Z2.T1D.T2B.X1E.X2F, Z3.T1D.T2B.X1E.X2F, Z4.T1D.T2B.X1E.X2F, Z1.T1E.T2B.X1E.X2F, Z2.T1E.T2B.X1E.X2F, Z3.T1E.T2B.X1E.X2F, Z4.T1E.T2B.X1E.X2F, Z1.T1F.T2B.X1E.X2F, Z2.T1F.T2B.X1E.X2F, Z3.T1F.T2B.X1E.X2F, Z4.T1F.T2B.X1E.X2F, Z1.T1A.T2C.X1E.X2F, Z2.T1A.T2C.X1E.X2F, Z3.T1A.T2C.X1E.X2F, Z4.T1A.T2C.X1E.X2F, Z1.T1B.T2C.X1E.X2F, Z2.T1B.T2C.X1E.X2F, Z3.T1B.T2C.X1E.X2F, Z4.T1B.T2C.X1E.X2F, Z1.T1C.T2C.X1E.X2F, Z2.T1C.T2C.X1E.X2F, Z3.T1C.T2C.X1E.X2F, Z4.T1C.T2C.X1E.X2F, Z1.T1D.T2C.X1E.X2F, Z2.T1D.T2C.X1E.X2F, Z3.T1D.T2C.X1E.X2F, Z4.T1D.T2C.X1E.X2F, Z1.T1E.T2C.X1E.X2F, Z2.T1E.T2C.X1E.X2F, Z3.T1E.T2C.X1E.X2F, Z4.T1E.T2C.X1E.X2F, Zl.T1F.T2C.X1E.X2F, Z2.T1F.T2C.X1E.X2F, Z3.T1F.T2C.X1E.X2F, Z4.T1F.T2C.X1E.X2F, Z1.T1A.T2D.X1E.X2F, Z2.T1A.T2D.X1E.X2F, Z3.T1A.T2D.X1E.X2F, Z4.T1A.T2D.X1E.X2F, Z1.T1B.T2D.XlE.X2F, Z2.T1B.T2D.X1E.X2F, Z3.T1B.T2D.X1E.X2F, Z4.T1B.T2D.X1E.X2F, Z1.T1C.T2D.X1E.X2F, Z2.T1C.T2D.X1E.X2F, Z3.T1C.T2D.X1E.X2F, Z4.T1C.T2D.X1E.X2F, Z1.T1D.T2D.X1E.X2F, Z2.T1D.T2D.X1E.X2F, Z3.T1D.T2D.XlE.X2F, Z4.T1D.T2D.X1E.X2F, Z1.T1E.T2D.X1E.X2F, Z2.T1E.T2D.X1E.X2F, Z3.T1E.T2D.X1E.X2F, Z4.T1E.T2D.X1E.X2F, Z1.T1F.T2D.X1E.X2F, Z2.T1F.T2D.X1E.X2F, Z3.T1F.T2D.XlE.X2F, Z4.T1F.T2D.XlE.X2F, Z1.T1A.T2E.X1E.X2F, Z2.T1A.T2E.X1E.X2F, Z3.T1A.T2E.X1E.X2F, Z4.T1A.T2E.X1E.X2F, Z1.T1B.T2E.X1E.X2F, Z2.T1B.T2E.X1E.X2F, Z3.T1B.T2E.X1E.X2F, Z4.T1B.T2E.X1E.X2F, Z1.T1C.T2E.X1E.X2F, Z2.T1C.T2E.X1E.X2F, Z3.T1C.T2E.X1E.X2F, Z4.T1C.T2E.X1E.X2F, Z1.T1D.T2E.X1E.X2F, Z2.T1D.T2E.X1E.X2F, Z3.T1D.T2E.X1E.X2F, Z4.T1D.T2E.X1E.X2F, Z1.T1E.T2E.X1E.X2F, Z2.T1E.T2E.X1E.X2F, Z3.T1E.T2E.X1E.X2F, Z4.T1E.T2E.X1E.X2F, Z1.T1F.T2E.X1E.X2F, Z2.T1F.T2E.X1E.X2F, Z3.T1F.T2E.X1E.X2F, Z4.T1F.T2E.XlE.X2F, Z1.T1A.T2F.X1E.X2F, Z2.T1A.T2F.X1E.X2F, Z3.T1A.T2F.X1E.X2F, Z4.T1A.T2F.X1E.X2F, Z1.T1B.T2F.X1E.X2F, Z2.T1B.T2F.X1E.X2F, Z3.T1B.T2F.X1E.X2F, Z4.T1B.T2F.X1E.X2F, Z1.T1C.T2F.X1E.X2F, Z2.T1C.T2F.X1E.X2F, Z3.T1C.T2F.X1E.X2F, Z4.T1C.T2F.X1E.X2F, Z1.T1D.T2F.X1E.X2F, Z2.T1D.T2F.X1E.X2F, Z3.T1D.T2F.X1E.X2F, Z4.T1D.T2F.X1E.X2F, Z1.T1E.T2F.X1E.X2F, Z2.T1E.T2F.X1E.X2F, Z3.T1E.T2F.X1E.X2F, Z4.TlE.T2F.X1E.X2F, Z1.T1F.T2F.X1E.X2F, Z2.T1F.T2F.X1E.X2F, Z3.T1F.T2F.X1E.X2F, Z4.T1F.T2F.X1E.X2F, Z1.T1A.T2A.X1F.X2F, Z2.T1A.T2A.X1F.X2F, Z3.T1A.T2A.X1F.X2F, Z4.T1A.T2A.X1F.X2F, Z1.T1B.T2A.X1F.X2F, Z2.T1B.T2A.X1F.X2F, Z3.T1B.T2A.X1F.X2F, Z4.T1B.T2A.X1F.X2F, Z1..T1C.T2A.X1F.X2F, Z2.T1C.T2A.X1F.X2F, Z3.T1C.T2A.X1F.X2F, Z4.T1C.T2A.X1F.X2F, Z1.T1D.T2A.X1F.X2F, Z2.T1D.T2A.X1F.X2F, Z3.T1D.T2A.X1F.X2F, Z4.T1D.T2A.X1F.X2F, Z1.T1E.T2A.X1F.X2F, Z2.T1E.T2A.X1F.X2F, Z3.T1E.T2A.X1F.X2F, Z4.T1E.T2A.X1F.X2F, Z1.T1F.T2A.X1F.X2F, Z2.T1F.T2A.X1F.X2F, Z3.T1F.T2A.X1F.X2F, Z4.T1F.T2A.X1F.X2F, Z1.T1A.T2B.X1F.X2F, Z2.T1A.T2B.X1F.X2F, Z3.T1A.T2B.X1F.X2F, Z4.T1A.T2B.X1F.X2F, Z1.T1B.T2B.X1F.X2F, Z2.T1B.T2B.X1F.X2F, Z3.T1B.T2B.X1F.X2F, Z4.T1B.T2B.X1F.X2F, Z1.T1C.T2B.X1F.X2F, Z2.T1C.T2B.X1F.X2F, Z3.T1C.T2B.X1F.X2F, Z4.T1C.T2B.X1F.X2F, Z1.T1D.T2B.X1F.X2F, Z2.T1D.T2B.X1F.X2F, Z3.T1D.T2B.X1F.X2F, Z4.T1D.T2B.X1F.X2F, Z1.T1E.T2B.X1F.X2F, Z2.T1E.T2B.X1F.X2F, Z3.T1E.T2B.X1F.X2F, Z4.T1E.T2B.X1F.X2F, Z1.T1F.T2B.X1F.X2F, Z2.T1F.T2B.X1F.X2F, Z3.T1F.T2B.X1F.X2F, Z4.T1F.T2B.X1F.X2F, Z1.T1A.T2C.X1F.X2F, Z2.T1A.T2C.X1F.X2F, Z3.T1A.T2C.X1F.X2F, Z4.T1A.T2C.X1F.X2F, Z1.T1B.T2C.X1F.X2F, Z2.T1B.T2C:X1F.X2F, Z3.T1B.T2C.X1F.X2F, Z4.T1B.T2C.X1F.X2F, Z1.T1C.T2C.X1F.X2F, Z2.T1C.T2C.X1F.X2F, Z3.T1C.T2C.X1F.X2F, Z4.T1C.T2C.XIF.X2F, Z1.T1D.T2C.X1F.X2F, Z2.T1D.T2C.X1F.X2F, Z3.T1D.T2C.XIF.X2F, Z4.T1D.T2C.X1F.X2F, Zl.T1E.T2C.X1F.X2F, Z2.T1E.T2C.X1F.X2F, Z3.T1E.T2C.X1F.X2F, Z4.T1E.T2C.X1F.X2F; Z1.T1F.T2C.X1F.X2F, Z2.T1F.T2C.X1F.X2F, Z3.T1F.T2C.X1F.X2F, Z4.T1F.T2C.X1F.X2F, Z1.T1A.T2D.X1F.X2F, Z2.T1A.T2D.X1F.X2F, Z3.T1A.T2D.X1F.X2F, Z4.TlA.T2D.X1F.X2F, Z1.T1B.T2D.X1F.X2F, Z2.T1B.T2D.X1F.X2F, Z3.T1B.T2D.X1F.X2F, Z4.T1B.T2D.X1F.X2F, Z1.T1C.T2D.X1F.X2F, Z2.T1C.T2D.X1F.X2F, Z3.T1C.T2D.X1F.X2F, Z4.T1C.T2D.X1F.X2F, Z1.T1D.T2D.X1F.X2F, Z2.T1D.T2D.X1F.X2F, Z3.T1D.T2D:X1F.X2F, Z4.T1D.T2D.X1F.X2F, Z1.T1E.T2D.X1F.X2F, Z2.T1E.T2D.X1F.X2F, Z3.T1E.T2D.X1F.X2F, Z4.T1E.T2D.X1F.X2F, Z1.T1F.T2D.X1F.X2F, Z2.T1F.T2D.X1F.X2F, Z3.T1F.T2D.X1F.X2F, Z4.T1F.T2D.X1F.X2F, Z1.T1A.T2E.X1F.X2F, Z2.T1A.T2E.X1F.X2F, Z3.T1A.T2E.X1F.X2F, Z4.T1A.T2E.X1F.X2F, Z1.T1B.T2E.X1F.X2F, Z2.T1B.T2E.X1F.X2F, Z3.T1B.T2E.X1F.X2F, Z4.T1B.T2E.X1F.X2F, Z1.T1C.T2E.X1F.X2F, Z2.T1C.T2E.X1F.X2F, Z3.T1C.T2E.X1F.X2F, Z4.T1C.T2E.X1F.X2F, Z1.T1D.T2E.X1F.X2F, Z2.T1D.T2E.X1F.X2F, Z3.T1D.T2E.X1F.X2F, Z4.T1D.T2E.X1F.X2F, Z1.T1E.T2E.X1F.X2F, Z2.TlE.T2E.X1F.X2F, Z3.T1E.T2E.X1F.X2F, Z4.T1E.T2E.X1F.X2F, Z1.T1F.T2E.X1F.X2F, Z2.T1F.T2E.X1F.X2F, Z3.T1F.T2E.X1F.X2F, Z4.T1F.T2E.X1F.X2F, Z1.T1A.T2F.X1F.X2F, Z2.T1A.T2F.X1F.X2F, Z3.T1A.T2F.X1F.X2F, Z4.T1A.T2F.X1F.X2F, Z1.T1B.T2F.X1F.X2F, Z2.T1B.T2F.X1F.X2F, Z3.T1B.T2F.X1F.X2F, Z4.T1B.T2F.X1F.X2F, Z1.T1C.T2F.X1F.X2F, Z2.T1C.T2F.X1F.X2F, Z3.T1C.T2F.X1F.X2F, Z4.T1C.T2F.X1F.X2F, Z1.T1D.T2F.X1F.X2F, Z2.T1D.T2F.X1F.X2F, Z3.T1D.T2F.X1F.X2F, Z4.T1D.T2F.X1F.X2F, Z1.T1E.T2F.X1F.X2F, Z2.T1E.T2F.X1F.X2F, Z3.T1E.T2F.X1F.X2F, Z4.T1E.T2F.X1F.X2F, Z1.T1F.T2F.X1F.X2F, Z2.T1F.T2F.X1F.X2F, Z3.T1F.T2F.X1F.X2F, Z4.T1F.T2F.X1F.X2F.

In still yet another embodiment, the compounds of Formula I are named below in tabular format (Table 30_6) as compounds of general Formula III:
x2 t1 t2 x1-~
As discussed above, each structure of a compound of Formula III can be designated in tabular form by combining the "code" representing each structural moiety using the following syntax: z.tl.t2.xl.x2. Thus, for example, zl.tla.t2b.xla.x2a represents the following structure:
~
OH O
O H H
N O
Oy N N H y O
O ~

Table 30.1: Core Structures Code Subgenus Structure zl x2 OH O
H
t1 N N

H ~
O
x1 Code Subgenus Structure z2 x2 OH O
% H t2 O
x1 z3 x2 H OH p~ ~p t1 _ N N H
/S\ t2 ~

O
x1 z4 x2 OH ~ O
t1%. N N\ ~
S N t2 II H
x1 TS x2 OH II
t1 N N\ ,S\
H t2 O
x1 Table 30.2: t1 Structures Code tl Structure tla v O
O
O
tib S`Z O

Code ti Structure tlc ,SS\
c' O
tld O
N J,, O
H
t]e H
N
Table 30.3: t2 Structures Code t2 Structure t2a io t2b O
H O
t2c O I ~
N

Code t2 Structure t2d N
N )~ H p `
I
~
t2e N
H
Table 30.4: xl Structures Code xl Structure xla I \
xlb F
xlc OMe xld F

Code xl Structure xle ~ I
xlf N
xlg ( I ~
xlh O Me N
. . I ~ /

Table 30.5: x2 Structures Code x2 Structure x2a x2b ~aF

Code x2 Strncture x2c F
x2d x2e . ~

x2f \ / I

x2g I x2h O
\ N
Table 30.6: List of Compound Structures of Formula III

zl.tla.t2a.xla.x2a, zl.tla.t2a.xla.x2b, zl.tla.t2a.xla.x2c, zl.tla.t2a.xla.x2d, zl.tla.t2a.xla.x2e, zl.tla.t2a.xla.x2f, zl.tla.t2a.xla.x2g, zl.tla.t2a.x1a.x2h, zl.tla.t2a.xlb.x2a, zl.tla.t2a.xlb.x2b, zl.tla.t2a.xlb.x2c, zl.tla.t2a.xlb.x2d, zl.tla.t2a.xlb.x2e, zl.tla.t2a.xlb.x2f, zl.tla.t2a.xlb.x2g, zl.tla.t2a.xlb.x2h, zl.tla.t2a.xlc.x2a, zl.tla.t2a.xlc.x2b, zl.tla.t2a.xlc.x2c, z1.t1a.t2a.xlc.x2d, zl.tla.t2a.xlc.x2e, zl.tla.t2a.xlc.x2f, zl.tla.t2a.x1c.x2g, zl.tla.t2a.xlc.x2h, zl.tla.t2a.xld.x2a, zl.tla.t2a.xld.x2b, zl.tla.t2a.xld.x2c, zl.tla.t2a.xld.x2d, zl.tla.t2a.xld.x2e, zl.tla.t2a.xld.x2f, zl.tla.t2a.xld.x2g, zl.tla:t2a.xld.x2h, zl.tla.t2a.xle.x2a, zl.tla.t2a.x1e.x2b, zl.tla.t2a.xle.x2c, zl.tla.t2a.xle.x2d, z1.t1a.t2a.xle.x2e, zl.tla.t2a.xle.x2f, zl.tla.t2a.xle.x2g, zl.tla.t2a.xle.x2h, zl.tla.t2a.x1f.x2a, zl.tla.t2a.xlf.x2b, zl.tla.t2a.xlf.x2c, zl.tla.t2a.xlf.x2d, zl.tla.t2a.xlf.x2e, zl.tla.t2a.x1f.x2f, zl.tla.t2a.xlf.x2g, zl.tla.t2a.xlf.x2h, zl.tla.t2a.xig.x2a, z1.t1a.t2a.xlg.x2b, zl.tla.t2a.xlg.x2c, zl.tla.t2a.xlg.x2d, zl.tla.t2a.xlg.x2e, zl.tla.t2a.xlg.x2f, zl.tla.t2a.xlg.x2g, zl.tla.t2a.x1g.x2h, zl.tla.t2a.xlh.x2a, zl.tla.t2a.xlh.x2b, zl.tla.t2a.x1h.x2c, zl.tla.t2a.x1h.x2d, zl.tla.t2a.xlh.x2e, zl.tla.t2a.xlh.x2f, zl.tla.t2a.xlh.x2g, zl.tla.t2a.xlh.x2h, z1.t1a.t2b.x1a.x2a, zl.tla.t2b.xla.x2b, zl.tla.t2b.xla.x2c, zl.tla.t2b.xla.x2d, zl.tla.t2b.x1a.x2e, zl.tla.t2b.xla.x2f, zl.tla.t2b.xla.x2g, zl.tla.t2b.xla.x2h, zl.tla.t2b.xlb.x2a, zl.tla.t2b.xlb.x2b, zl.tla.t2b.xlb.x2c, zl.tla.t2b.x1b.x2d, zl.tla.t2b.xlb.x2e, zl.tla.t2b.xlb.x2f, z1.t1a.t2b.xlb.x2g, zl.tla.t2b.xlb.x2h, zl.tla.t2b.xlc.x2a, zl.tla.t2b.xlc.x2b, zl.tla.t2b.xlc.x2c, zl.tla.t2b.xlc.x2d, zl.tla.t2b.xlc.x2e, zl.tla.t2b.xlc.x2f, z1.t1a.t2b.xlc.x2g, zl.tla.t2b.xlc.x2h, zl.tla.t2b.xld.x2a, zl.tla.t2b.xld.x2b, zl.tla.t2b.xld.x2c, zl.tla.t2b.xld.x2d, z1.t1a.t2b.xld.x2e, zl.tla.t2b.xld.x2f, zl.tla.t2b.xld.x2g, zl.tla.t2b.xld.x2h, z1.t1a.t2b.x1e.x2a, zl.tla.t2b.xle.x2b, zl.tla.t2b.xle.x2c, zl.tla.t2b.xle.x2d, zl.tla.t2b.xle.x2e, zl.tla.t2b.xle.x2f, zl.tla.t2b.xle.x2g, zl.tla.t2b.xle.x2h, zl.tla.t2b.x1f.x2a, zl.tla.t2b.xlf.x2b, zl.tla.t2b.xlf.x2c, zl.tla.t2b.x1f.x2d, z1.t1a.t2b.x1f.x2e, zl.tla.t2b.xlf.x2f, zl.tla.t2b.xlf.x2g, zl.tla.t2b.xlf.x2h, zl.tla.t2b.xlg.x2a, zl.tla.t2b.xlg.x2b, zl.tla.t2b.xlg.x2c, zl.tla.t2b.x1g.x2d, zl.tla.t2b.xlg.x2e, zl.tla.t2b.xlg.x2f, z1.t1a.t2b.xlg.x2g, zl.tla.t2b.xlg.x2h, zl.tla.t2b.xlh.x2a, zl.tla.t2b.xlh.x2b, zl.tla.t2b.xlh.x2c, zl.tla.t2b.xlh.x2d, zl.tla.t2b.xlh.x2e, zl.tla.t2b.x1h.x2f, zl.tla.t2b.x1h.x2g, zl.tla.t2b.x1h.x2h, zl.tla.t2c.xla.x2a, zl.tla.t2c.xla.x2b, zl.tla.t2c.xla.x2c, zl.tla.t2c.x1a.x2d, zl.tla.t2c.xla.x2e, zl.tla.t2c.xla.x2f, z1.t1a.t2c.xla.x2g, zl.tla.t2c.xla.x2h, zl.tla.t2c.xlb.x2a, zl.tla.t2c.xlb.x2b, zl.tla.t2c.xlb.x2c, zl.tla.t2c.xlb.x2d, zl.tla.t2c.xlb.x2e, zl.tla.t2c.xlb.x2f, zl.tla.t2c.xlb.x2g, zl.tla.t2c.xlb.x2h, 35. zl.tla.t2c.xlc.x2a, zl.tla.t2c.xlc.x2b, zl.tla.t2c.xlc_x2c, z1.t1a.t2c.x1c.x2d, zl.tla.t2c.xlc.x2e, zl.tla.t2c.xlc.x2f, zl.tla.t2c.xlc.x2g, z1.t1a.t2c.xlc.x2h, zl.tla.t2c.xld.x2a, zl.tla.t2c.xld.x2b, z1.t1a.t2c.xld.x2c, zl.tla.t2c.xld.x2d;
zl.tla.t2c.xld.x2e, zi.tla.t2c.xld.x2f, zl.tla.t2c.xld.x2g, zl.tla.t2c.xld.x2h, zl.tla.t2c.xle.x2a, zl.tla.t2c.xle.x2b, zl.tla.t2c.xle.x2c, zl.tla.t2c.xle.x2d, zl.tla.t2c.xle.x2e, zl.tla.t2c.xle.x2f, zl.tla.t2c.x1e.x2g, zl.tla.t2c.xle.x2h, zl.tla.t2c.xlf.x2a, zl.tla.t2c.x1f.x2b, zl.tla.t2c.xlf.x2c, zl.tla.t2c.x1f.x2d, zl.tla.t2c.xlf.x2e, zl.tla.t2c.xlf.x2f, zl.tla.t2c.xlf.x2g, z1.t1a.t2c.xlf.x2h, zl.tla.t2c.xlg.x2a, zl.tla.t2c.xlg.x2b, zl.tla.t2c.xlg.x2c, zl.tla.t2c.xlg.x2d, zl.tla.t2c.x1g.x2e, zl.tla.t2c.xlg.x2f, zl.tla.t2c.xlg.x2g, z1.t1a.t2c.xlg.x2h, zl.tla.t2c.x1h.x2a, zl.tla.t2c.xlh.x2b, zl.tla.t2c.xlh.x2c, zl.tla.t2c.xlh.x2d, zl.tla.t2c.xlh.x2e, zl.tla.t2c.xlh.x2f, zl.tla.t2c.xlh.x2g, zl.tla.t2c.xlh.x2h, zl.tla.t2d.xla.x2a, zl.tla.t2d.xla.x2b, zl.tla.t2d.xla.x2c, zl.tla.t2d.xla.x2d, z1.t1a.t2d.xla.x2e, zl_t1a.t2d.x1a.x2f, zl.tla.t2d.x1a.x2g, zl.tla.t2d.xla.x2h, z1.t1a.t2d.xlb.x2a, zl.tla.t2d.xlb.x2b, zl.tla.t2d.x1b.x2c, zl.tla.t2d.xlb.x2d, zl.tla.t2d.xlb.x2e, zl.tla.t2d.xlb.x2f, zl.tla.t2d.xlb.x2g, zl.tla.t2d.xlb.x2h, -5 zl.tla.t2d.xlc.x2a, zl.tla.t2d.xlc.x2b, zl:tla.t2d.xlc.x2c, zl.tla.t2d.xlc.x2d, zl.tla.t2d.xlc.x2e, zl.tla.t2d.xlc.x2f, zl.tla.t2d.xlc.x2g, zl.tla.t2d.xlc.x2h, zl.tla.t2d.x1d.x2a, zl.tla.t2d.xld.x2b, zl.tla.t2d.xld.x2c, zl.tla.t2d.xld.x2d, zl.tla.t2d.x1d.x2e, zl.tla.t2d.xld.x2f, zl.tla.t2d.x1d.x2g, zl.tla.t2d.xld.x2h, zl.tla.t2d.x1e.x2a, zl.tla.t2d.xle.x2b, zl.tla.t2d.xle.x2c, zi.tla.t2d.xle.x2d, zl.tla.t2d.x1e.x2e, zi.tla.t2d.xle.x2f, zl.tla.t2d.xle.x2g, zl.tla.t2d.xle.x2h, zl.tla.t2d.x1f.x2a, zl.tla.t2d.x1f.x2b, zl.tla.t2d.xlf.x2c, zl.tla.t2d.xlf.x2d, zl.tla.t2d.xlf.x2e, zl.tla.t2d.xlf.x2f, zl.tla.t2d.xlf.x2g, zl.tla.t2d.xlf.x2h, zl.tla.t2d.x1g.x2a, zl.tla.t2d.xlg.x2b, zl.tla.t2d.xlg.x2c, zl.tla:t2d.x1g.x2d, zl.tla.t2d.x1g.x2e, zl.tla.t2d.xlg.x2f, zl.tla.t2d.xlg.x2g, zl.tla.t2d.xlg.x2h, zl.tla.t2d.xlh.x2a, zl.tla.t2d.xlh.x2b, zl.tla.t2d.xlh.x2c, zl.tla.t2d.xlh.x2d, zl.tla.t2d.x1h.x2e, zl.tla.t2d.xlh.x2f, zl.tla.t2d.x1h.x2g, zl.tla.t2d.xlh.x2h, zl.tla.t2e.xla.x2a, zl,.tla.t2e.x1a.x2b, zl.tla.t2e.xla.x2c, zl.tla.t2e.xla.x2d, zl.tla.t2e.xla.x2e, zl.tla.t2e.xla.x2f, zl.tla.t2e.x1a.x2g, zl.tla.t2e.xla.x2h, zl.tla.t2e.x1b.x2a, zl.tla.t2e.xlb.x2b, zl.tla.t2e.xlb.x2c, zl.tla.t2e.xlb.x2d, zl.tla.t2e.xlb.x2e, zl.tla.t2e.xlb.x2f, zl.tla.t2e.xlb.x2g, zl.tla.t2e.xlb.x2h, zl.tla.t2e.xlc.x2a, zl.tla.t2e.xlc.x2b, zl.tla.t2e.xlc.x2c, zl.tla.t2e.xlc.x2d, zl.tla.t2e.xlc.x2e, zl.tla.t2e.xlc.x2f, zl.tla.t2e.xlc.x2g, zl.tla.t2e.xlc.x2h, zl.tla.t2e.xld.x2a, zl.tla.t2e.xld.x2b, zi.tla.t2e.xld.x2c, zl.tla.t2e.xld.x2d, zl.tla.t2e.xld.x2e, zl.tla.t2e.xld.x2f, zl.tla.t2e.xld.x2g, zl.tla.t2e.xld.x2h, zl.tla.t2e.x1e.x2a, zl.tla.t2e.xle.x2b, zl.tla.t2e.xle.x2c, zl.tla.t2e.xle.x2d, zl.tla.t2e.xle.x2e, zl.tla.t2e.xle.x2f, zl.tla.t2e.xle.x2g, zl.tla.t2e.xle.x2h, zl.tla.t2e.xlf.x2a, zl.tla.t2e.xlf.x2b, zl.tla.t2e.xlf.x2c, zl.tla.t2e.xlf.x2d, zl.tia.t2e.x1f.x2e, zl.tla.t2e.xlf.x2f, zl.tla.t2e.xlf.x2g, zl.tla.t2e.xlf.x2h, zl.tla.t2e.x1g.x2a, zl.tla.t2e.xlg.x2b, zl.tla.t2e.xlg.x2c, zl.tla.t2e.xlg.x2d, zl.tla.t2e.x1g.x2e, zl.tla.t2e.x1g.x2f, zl.tla.t2e.xlg.x2g, zl.tla.t2e.xlg.x2h, zl.tla.t2e.xlh.x2a, zl.tla.t2e.xlh.x2b, zl.tla.t2e.xlh.x2c, zl.tla.t2e.xlh.x2d, zl.tla.t2e.xlli.x2e, zl.tla.t2e.xlh.x2f, zl.tla.t2e.xlh.x2g, zi.tla.t2e.x1h.x2h, zl.tlb.t2a.xla.x2a, zl.tlb.t2a.xla.x2b, zl.tlb.t2a.xla.x2c, zl.tlb.t2a.xla.x2d, zl.tlb.t2a.x1a.x2e, zl.tlb.t2a.xla.x2f, zl.tlb.t2a.xla.x2g, zl.tlb.t2a.xla.x2h, zl.tlb.t2a.xlb.x2a, zl.tlb.t2a.xlb.x2b, zl.tlb.t2a.xlb.x2c, zl.tlb.t2a.xlb.x2d, zl.tlb.t2a.xlb.x2e, zl.tlb.t2a.xlb.x2f, zl.tlb.t2a.xlb.x2g, zl.tlb.t2a.xlb.x2h, zl.tlb.t2a.xlc.x2a, zl.tlb.t2a.x1c.x2b, zl.tlb.t2a.xlc.x2c, zl.tlb.t2a.xlc.x2d, zl.tlb.t2a.xlc.x2e, zl.tlb.t2a.xlc.x2f, zi.tlb.t2a.xlc.x2g, zi.tlb.t2a.xlc.x2h, zl.tlb.t2a.xld.x2a, zl.tlb.t2a.xld.x2b, zl.tlb.t2a.xld.x2c, zl.tlb.t2a.xld.x2d, z1.t1b.t2a.xld.x2e, zl.tlb.t2a.xld.x2f, zl.tlb.t2a.xld.x2g, zl.tlb.t2a.xld.x2h, zl.tlb.t2a.xle.x2a, zl.tlb.t2a.xle.x2b, zl.tlb.t2a.xle.x2c, zl.tlb.t2a.xle.x2d, z1.t1b.t2a.xle.x2e, zl.tlb.t2a.xle.x2f, zl.tlb.t2a.xle.x2g, zl.tlb.t2a.xle.x2h, zl.tlb.t2a.xlf.x2a, zl.tlb.t2a.xlf.x2b, zl.tlb.t2a.xlf.x2c, zl.tlb.t2a.xlf.x2d, zl.tlb.t2a.xlf.x2e, zl.tlb.t2a.xlf.x2f, zl.tlb.t2a.xlf.x2g, z1.t1b.t2a.x1f.x2h, zl.tlb.t2a.xlg.x2a, zl.tlb.t2a.xlg.x2b, zl.tlb.t2a.x1g.x2c, zl.tlb.t2a.xlg.x2d, zl.tlb.t2a.x1g.x2e, z1.t1b.t2a.xlg.x2f, zl.tlb.t2a.x1g.x2g, zl.tlb.t2a.xlg.x2h, zi.tlb.t2a.xlh.x2a, zl.tlb.t2a.xlh.x2b, zl.tlb.t2a.x1h.x2c, zl.tlb.t2a.x1h.x2d, zl.tlb.t2a.x1h.x2e, zl.tlb.t2a.xlh.x2f, zl.tlb.t2a.xlh.x2g, zl.tlb.t2a.xlh.x2h, zl.tlb.t2b.xla.x2a, zl.tlb.t2b.xla.x2b, zl.tlb.t2b.xla.x2c, zl.tlb.t2b.x1a.x2d, zl.tlb.t2b.xla.x2e, zl.tlb.t2b.xla.x2f, zl.tlb.t2b.xla.x2g, zl.tlb.t2b.xla.x2h, zl.tlb.t2b.xlb.x2a, zl.tlb.t2b.xlb.x2b, zl.tlb.t2b.xlb.x2c, zl.tlb.t2b.xlb.x2d, zl.tlb.t2b.xlb.x2e, zl.tlb.t2b.xlb.x2f, zl.tlb.t2b.xlb.x2g, zl.tlb.t2b.x1b.x2h, zl.tlb.t2b.xlc.x2a, zl.tlb.t2b.x1c.x2b, zl.tlb.t2b.xlc.x2c, zl.tlb.t2b.xlc.x2d, zl.tlb.t2b.xlc.x2e, zi.tlb.t2b.x1c.x2f, zl.tlb.t2b.xlc.x2g, zl.tlb.t2b.xlc.x2h, zl.tlb.t2b.xld.x2a, z1.t1b.t2b.x1d.x2b, zl.tlb.t2b.x1d.x2c, zl.tlb.t2b.xld.x2d, zl.tlb.t2b.xld.x2e, zl.tlb.t2b.x1d.x2f, zl.tlb.t2b.xld.x2g, zl.tlb.t2b.xld.x2h, zl.tlb.t2b.xle.x2a, zl.tlb.t2b.xle.x2b, zl.tlb.t2b.xle.x2c, z1.t1b.t2b.xle.x2d, zl.tlb.t2b.x1e.x2e, zl.tlb.t2b.xle.x2f, zl.tlb.t2b.xle.x2g, zl.tlb.t2b.xle.x2h, zl.tlb.t2b.xlf.x2a, zl.tlb.t2b.xlf.x2b, zl.tlb.t2b.xlf.x2c, zl.tlb.t2b.x1f.x2d, zl.tlb.t2b.xlf.x2e;-zl.tlb.t2b.xlf.x2f, zl.tlb.t2b.xlf.x2g, zl.tlb.t2b.xlf.x2h, zl.tlb.t2b.xlg.x2a, z1.t1b.t2b.x1g.x2b, zl.tlb.t2b.xlg.x2c, zl.tlb.t2b.xlg.x2d, zl.tlb.t2b.xlg.x2e, zl.tlb.t2b.xlg.x2f, zl.tlb.t2b.xlg.x2g, zl.tlb.t2b.x1g.x2h, zl.tlb.t2b.xlh.x2a; zl.tlb.t2b.x1h.x2b, zl.tlb.t2b.xlh.x2c, zl.tlb.t2b.xlh.x2d, zl.tlb.t2b.xlh.x2e, zl.tlb.t2b.xlh.x2f, zl.tlb.t2b.xlh.x2g, zl.tlb.t2b.xlh.x2h, zi.tlb.t2c.xla.x2a, zl.tlb.t2c.xla.x2b, zl.tlb.t2c.xla.x2c, zl.tlb.t2c.xla.x2d, zl.tlb.t2c.xla.x2e, zl.tlb.t2c.xla.x2f, zl.tlb.t2c.xla.x2g, zl.tlb.t2c.xla.x2h, zl.tlb.t2c.x1b.x2a, z1.t1b.t2c.x1b.x2b, zl.tlb.t2c.xlb.x2c, zl.tlb.t2c.xlb.x2d, zl.tlb.t2c.x1b.x2e, z1.t1b.t2c.x1b.x2f, zl.tlb.t2c.xlb.x2g, z1.t1b.t2c.xlb.x2h, zl.tlb.t2c.xlc.x2a, zi.tlb.t2c.xlc.x2b, zl.tlb.t2c.xlc.x2c, zl.tlb.t2c.xlc.x2d, zl.tlb.t2c.x1c.x2e, zl.tlb.t2c.xlc.x2f, zl.tlb.t2c.xlc.x2g, zl.tlb.t2c.xlc.x2h, zl.tlb.t2c.x1d.x2a, zl.tlb.t2c.x1d.x2b, z1.t1b.t2c.x1d.x2c, zl.tlb.t2c.xld.x2d, zl.tlb.t2c.xld.x2e, zl.tlb_t2c.xld.x2f, zl.tlb.t2c.xld.x2g, zl.tlb.t2c.x1d.x2h, zl.tlb.t2c.x1e.x2a, zl.tlb.t2c.xle.x2b, zl.tlb.t2c.xle.x2c, zl.tlb.t2c.x1e.x2d, zl.tlb.t2c.xle.x2e, zl.tlb.t2c.xle.x2f, zl.tlb.t2c.x1e.x2g, zl.tlb.t2c.xle.x2h, zl.tlb.t2c.x1f.x2a, zl.tlb.t2c.xlf.x2b, zl.tlb.t2c.x1f.x2c, zl.tlb.t2c.x1f.x2d, z1.t1b.t2c.x1f.x2e, zl.tlb.t2c.xlf.x2f, zl.tlb.t2c.xlf.x2g, zl.tlb.t2c.xlf.x2h, zl.tlb.t2c.xlg.x2a, zl.tlb.t2c.xlg.x2b, zl.tlb.t2c.xlg.x2c, zl.tlb.t2c.xlg.x2d, zl.tlb:t2c.xlg.x2e, zl.tlb.t2c.xlg.x2f, zl.tlb.t2c.xlg.x2g, zl.tlb.t2c.xlg.x2h, z1.t1b.t2c.xlh.x2a, zl.tlb.t2c.xlh.x2b, zl.tlb.t2c.xlh.x2c, zl.tlb.t2c.xlh.x2d, zl.tlb.t2c.xlh.x2e, zl.tlb.t2c.xlh.x2f, zl.tlb.t2c.x1h.x2g, zl.tlb.t2c.xlh.x2h, zl.tlb.t2d.x1a.x2a, zl.tlb.t2d.xla.x2b, zl.tlb.t2d.xla.x2c, zl.tlb.t2d.xla.x2d, zl.tlb.t2d.xla.x2e, z1.t1b.t2d.x1a.x2f, zl.tlb.t2d.xla.x2g, zl.tlb.t2d.xla.x2h, zl.tlb.t2d.x1b.x2a, zl.tlb.t2d.xlb.x2b, zl.tlb.t2d.xlb.x2c, z1.t1b.t2d.x1b.x2d, zl.tlb.t2d.xlb.x2e, zl.tlb.t2d.xlb.x2f, zl.tlb.t2d.xlb.x2g, zl.tlb.t2d.xlb.x2h, zl.tlb.t2d.x1c.x2a, zl.tlb.t2d.xlc.x2b, z1.t1b.t2d.x1c.x2c, zl.tlb.t2d.xlc.x2d, zl.tlb.t2d.xlc.x2e, zl.tlb.t2d.xlc.x2f, zl.tlb.t2d.xlc.x2g, zl.tlb.t2d.xlc.x2h, zl.tlb.t2d.xld.x2a, z1.t1b.t2d.xld.x2b, z1.t1b.t2d.x1d.x2c, z1.t1b.t2d.x1d.x2d, zl.tlb.t2d.xld.x2e, zl.tlb.t2d.x1d.x2f, z1.t1b.t2d.xld.x2g, zl.tlb.t2d.x1d.x2h, zl.tlb.t2d.x1e.x2a, zl.tlb.t2d.x1e.x2b, zl.tlb.t2d.xle.x2c, zl.tlb.t2d.xle.x2d, zl.tlb.t2d.x1e.x2e, zi.tlb.t2d.xle.x2f, zl.tlb.t2d.xle.x2g, z1.t1b.t2d.x1e.x2h, zl.tlb.t2d.xlf.x2a, zl.tlb.t2d.xlf.x2b, zl.tlb.t2d.xlf.x2c, zl.tlb.t2d.x1f.x2d, zl.tlb.t2d.xlf.x2e, zl.tlb.t2d.xlf.x2f, zl.tlb.t2d.xlf.x2g, zl.tlb.t2d.x1f.x2h, zl.tlb.t2d.x1g.x2a, z1.t1b.t2d.xlg.x2b, z1.t1b.t2d.xlg.x2c, zl.tlb.t2d.xlg.x2d, zl.tlb.t2d.xlg.x2e, zl.tlb.t2d.xlg.x2f, zl.tlb.t2d.xlg.x2g, zl.tlb.t2d.xlg.x2h, zl.tlb.t2d.xlh.x2a, z1.t1b.t2d.x1h.x2b, z1.t1b.t2d.xlh.x2c, zl.tlb.t2d.x1h.x2d, zl.tlb.t2d.xlh.x2e, zl.tlb.t2d.xlh.x2f, zl.tlb.t2d.xlh.x2g, zl.tlb.t2d.xlh.x2h, zl.tlb.t2e.xla.x2a, zl.tlb.t2e.xla.x2b, zl.tlb.t2e.xla.x2c, zl.tlb.t2e.xla.x2d, zl.tlb.t2e.xla.x2e, zl.tlb.t2e.xla.x2f, zl.tlb.t2e.x1a.x2g, zl.tlb.t2e.xla.x2h, zl.tlb.t2e.xlb.x2a, zl.tlb.t2e.x1b.x2b, zl.tlb.t2e.xlb.x2c, zl.tlb.t2e.xlb.x2d, zl.tlb.t2e.xlb.x2e, zl.tlb.t2e.xlb.x2f, zl.tlb.t2e.xlb.x2g, zl.tlb.t2e.xlb.x2h, zl.tlb.t2e.xlc.x2a, zl.tlb.t2e.xlc.x2b, zl.tlb.t2e.x1c.x2c, zl.tlb.t2e.xlc.x2d, zl.tlb.t2e.x1c.x2e, zl.tlb.t2e.xlc.x2f, zl.tlb.t2e.xlc.x2g, z1.t1b.t2e.x1c.x2h, z1.t1b.t2e.x1d.x2a, zl.tlb.t2e.x1d.x2b, zl.tlb.t2e.xld.x2c, zl.tlb.t2e.xld.x2d, z1.tlb.t2e.x1d.x2e, zl.tlb.t2e.xld.x2f, zl.tlb.t2e.xld.x2g, zl.tlb.t2e.x1d.x2h, zl.tlb.t2e.xle.x2a, zl.tlb.t2e.x1e.x2b, zl.tlb.t2e.xle.x2c, z1.t1b.t2e.x1e.x2d, zl.tlb.t2e.x1e.x2e, zl.tlb.t2e.xle.x2f, zl.tlb.t2e.xle.x2g, zl.tlb.t2e.x1e.x2h, zl.tlb.t2e.x1f.x2a, z1.t1b.t2e.xlf.x2b, zl.tlb.t2e.xlf.x2c, zl.tlb.t2e.x1f.x2d, zl.tlb.t2e.xlf.x2e, zl.tlb.t2e.xlf.x2f, zl.tlb.t2e.xlf.x2g, z1.t1b.t2e.xlf.x2h, zl.tlb.t2e.xlg.x2a, zl.tlb.t2e.xlg.x2b, zl.tlb.t2e.xlg.x2c, zl.tlb.t2e.xlg.x2d, zl.tlb.t2e.xlg.x2e, zl.tlb.t2e.xlg.x2f, zl.tlb.t2e.xlg.x2g, zl.tlb.t2e.xlg.x2h, zl.tlb.t2e.xlh.x2a, zl.tlb.t2e.xlh.x2b, zl.tlb.t2e.xlh.x2c, zl.tlb.t2e.xlh.x2d, zl.tlb.t2e.xlh.x2e, zl.tlb.t2e.xlh.x2f, zl.tlb.t2e.xlh.x2g, zl.tlb.t2e.xlh.x2h, zl.tlc.t2a.xla.x2a, zl.tlc.t2a.xla.x2b, zl.tlc.t2a.xla.x2c, z1.t1c.t2a.xla.x2d, zl.tlc.t2a.xla.x2e, zl.tlc.t2a.xla.x2f, zl.tlc.t2a.xla.x2g, zl.tlc.t2a.xla.x2h, zl.tlc.t2a.xlb.x2a, zl.tlc.t2a.xlb.x2b, zl.tlc.t2a.x1b.x2c, zi.tlc.t2a.xlb.x2d, zl.tlc.t2a.xlb.x2e, zl.tlc.t2a.xlb.x2f, z1.t1c.t2a.xlb.x2g, zl.tlc.t2a.xlb.x2h, zl.tlc.t2a.xlc.x2a, zl.tlc.t2a.xlc.x2b, zl.tlc.t2a.xlc.x2c, zl.tlc.t2a.x1c.x2d, zl.tlc.t2a.xlc.x2e, z1.t1c.t2a.x1c.x2f, z1.t1c.t2a.xlc.x2g, zi.tlc.t2a.x1c.x2h, zl.tlc.t2a.xld.x2a, zl.tlc.t2a.xld.x2b, zl.tlc.t2a.xld.x2c, zl.tlc.t2a.xld.x2d, zl.tlc.t2a.xld.x2e, zl.tlc.t2a.xld.x2f, zl_t1c.t2a.x1d.x2g, zl.tlc.t2a.xld.x2h, zl.tlc.t2a.x1e.x2a, zl.tlc.t2a.xle.x2b, zl.tlc.t2a.xle.x2c, zl.tlc.t2a.xle.x2d, z1.t1c.t2a.x1e.x2e, zl.tlc.t2a.x1e.x2f, zl.tlc.t2a.xle.x2g, zl.tlc.t2a.x1e.x2h, zl.tlc.t2a.xlf.x2a, zl.tlc.t2a.xlf.x2b, zl.tlc.t2a.xlf.x2c, zl.tlc.t2a.xlf.x2d, zl.tlc.t2a.xlf.x2e, zi.tlc.t2a.xlf.x2f, zi.tlc.t2a.xlf.x2g, zl.tlc.t2a.xlf.x2h, zl.tlc.t2a.xlg.x2a, zl.tlc.t2a.xlg.x2b, zl.tlc.t2a.x1g.x2c, zl.tlc.t2a.xlg.x2d, zl.tlc.t2a.xlg.x2e, zl.tlc.t2a.xlg.x2f, zl.tlc.t2a.xlg.x2g, zl.tlc.t2a.xlg.x2h, zl.tlc.t2a.xlh.x2a, zl.tlc.t2a.xlh.x2b, zl.tlc.t2a.xlh.x2c, z1.t1c.t2a.x1h.x2d, z1.t1c.t2a.x1h.x2e, zl.tlc.t2a.xlh.x2f, zl.tlc.t2a.xlh.x2g, zl.tlc.t2a.xlh.x2h, zl.tlc.t2b.xla.x2a, z1.t1c.t2b.xla.x2b, z1.t1c.t2b.x1a.x2c, zl.tlc.t2b.xla.x2d, zl.tlc.t2b.xla.x2e, zl.tlc.t2b.xla.x2f, zl.tlc.t2b.xla.x2g, zl.tlc.t2b.xla.x2h, zl.tlc.t2b.xlb.x2a, zl.tlc.t2b.x1b.x2b, zl.tlc.t2b.xlb.x2c, zl.tlc.t2b.xlb.x2d, zl.tlc.t2b.xlb.x2e, zl.tlc.t2b.xlb.x2f, zl.tlc.t2b.xlb.x2g, zl.tlc.t2b.xlb.x2h, zl.tlc.t2b.xlc.x2a, zl.tlc.t2b.xlc.x2b, zl.tlc.t2b.xlc.x2c, zl.tlc.t2b.xlc.x2d, zl.tlc.t2b.xlc.x2e, zl.tlc.t2b.xlc.x2f, zi.tlc.t2b.xlc.x2g, zl.tlc.t2b.xlc.x2h, zl.tlc.t2b.xld.x2a, zl.tlc.t2b.xld.x2b, zl.tlc.t2b.xld.x2c, zl.tlc.t2b.x1d.x2d, zl.tlc.t2b.x1d.x2e, zl.tlc.t2b.xld.x2f, zl.tlc.t2b.xld.x2g, zl.tlc.t2b.x1d.x2h, zl.tlc.t2b.xle.x2a, zl.tlc.t2b.xle.x2b, zl.tlc.t2b.xle.x2c, zl.tlc.t2b.xle.x2d, zl.tlc.t2b.x1e.x2e, zl.tlc.t2b.xle.x2f, z1.t1c.t2b.x1e.x2g, zl.tlc.t2b.xle.x2h, zl.tlc.t2b.x1f.x2a, zl.tlc.t2b.xlf.x2b, zl.tlc.t2b.xlf.x2c, zl.tlc.t2b.xlf.x2d, zl.tlc.t2b.xlf.x2e, zl.tlc.t2b.x1f.x2f, zl.tlc.t2b.xlf.x2g, zl.tlc.t2b.xlf.x2h, zl.tlc.t2b.xlg.x2a, zi.tlc.t2b.xlg.x2b, zl.tlc.t2b.xlg.x2c, zl.tlc.t2b.xlg.x2d, zl.tlc.t2b.x1g.x2e, zl.tlc.t2b.xlg.x2f, z1.t1c.t2b.xlg.x2g, zl.tlc.t2b.xlg.x2h, zl.tlc.t2b.xlh.x2a, zl.tlc.t2b.xlh.x2b, zl.tlc.t2b.xlh.x2c, zl.tlc.t2b.xlh.x2d, zl.tlc.t2b.xlh.x2e, zl.tlc.t2b.xlh.x2f, zl.tlc.t2b.xlh.x2g, zl.tlc.t2b.xlh.x2h, zl.tlc.t2c.xla.x2a, zl.tlc.t2c.xla.x2b, zl.tlc.t2c.x1a.x2c, zl.tlc.t2c.xla.x2d, zl.tlc.t2c.xla.x2e, zl.tlc.t2c.xla.x2f, zl.tlc.t2c.xla.x2g, zl.tlc.t2c.xla.x2h, zl.tlc.t2c.x1b.x2a, zl.tlc.t2c.xlb.x2b, zi.tlc.t2c.x1b.x2c, zl.tlc.t2c.xlb.x2d, zl.tlc.t2c.xlb.x2e, zl.tlc.t2c.xlb.x2f, zl.tlc.t2c.xlb.x2g, zl.tlc.t2c.xlb.x2h, zl.tlc.t2c.xlc.x2a, zl.tlc.t2c.xlc.x2b, zl.tlc.t2c.xlc.x2c, zl.tlc.t2c.xlc.x2d, zl.tlc.t2c.xlc.x2e, zl.tlc.t2c.xlc.x2f, zl.tlc.t2c.xlc.x2g, zl.tlc.t2c.xlc.x2h, zl.tlc.t2c.xld.x2a, zl.tlc.t2c.xld.x2b, zl.tlc.t2c.xld.x2c, zl.tlc.t2c.xld.x2d, zl.tlc.t2c.xld.x2e, zl.tlc.t2c.xld.x2f, zl.tlc.t2c.xld.x2g, zl.tlc.t2c.x1d.x2h, zl.tlc.t2c.xle.x2a, zl.tlc.t2c.xle.x2b, zl.tlc.t2c.xle.x2c, zl.tlc.t2c.xle.x2d, zl.tlc.t2c.xle.x2e, zl.tlc.t2c.xle.x2f, zl.tlc.t2c.x1e.x2g, zl.tlc.t2c.xle.x2h, zl.tlc.t2c.x1f.x2a, zl.tlc.t2c.x1f.x2b, zl.tlc.t2c.xlf.x2c, zl.tlc.t2c.x1f.x2d, zl.tlc.t2c.xlf.x2e, zl.tlc.t2c.xlf.x2f, zl.tlc.t2c.xlf.x2g, zl.tlc.t2c.xlf.x2h, zl.tlc.t2c.xlg.x2a, zl.tlc.t2c.xlg.x2b, zl.tlc.t2c.xlg.x2c, zl.tlc.t2c.x1g.x2d, zl.tlc.t2c.xlg.x2e, zl.tlc.t2c.xlg.x2f, zl.tlc.t2c.xlg.x2g, zl.tlc.t2c.xlg.x2h, z1.t1c.t2c.xlh.x2a, zl.tlc.t2c.xlh.x2b, zl.tlc.t2c.xlh.x2c, zl.tlc.t2c.xlh.x2d, zl.tlc.t2c.xlh.x2e, zl.tlc.t2c.xlh.x2f, zl.tlc.t2c.x1h.x2g, zl.tlc.t2c.x1h.x2h, zi.tlc.t2d.xla.x2a, zl.tlc.t2d.xla.x2b, zl.tlc.t2d.x1a.x2c, zl.tlc.t2d.xla.x2d, zl.tlc.t2d.xla.x2e, zl.tlc.t2d.xla.x2f, zl.tlc.t2d.xla.x2g, zl.tlc.t2d.xla.x2h, zl.tlc.t2d.xlb.x2a, zl.tlc.t2d.xlb.x2b, zl.tlc.t2d.xlb.x2c, zl.tlc.t2d.xlb.x2d, zl.tlc.t2d.xlb.ic2e, zl.tlc.t2d.xlb.x2f, zl.tlc.t2d.xlb.x2g, zl.tlc.t2d.xlb.x2h, zl.tlc.t2d.xlc.x2a, zl.tlc.t2d.xlc.x2b, zl.tlc.t2d.xlc.x2c, zl.tlc.t2d.xlc.x2d, zl.tlc.t2d.x1c.x2e, zl.tlc.t2d.x1c.x2f, zl.tlc.t2d.xlc.x2g, zl.tlc.t2d.xlc.x2h, zl.tlc.t2d.xld.x2a, zl.tlc.t2d.xld.x2b, zl.tlc.t2d.xld.x2c, zl.tlc.t2d.xld.x2d, zl.tlc.t2d.xld.x2e, zl.tlc.t2d.xld.x2f, zl.tlc.t2d.xld.x2g, zl.tlc.t2d.xld.x2h, zl.tlc.t2d.xle.x2a, zl.tlc.t2d.xle.x2b, zl.tlc.t2d.xle.x2c, zl.tlc.t2d.xle.x2d, z1.t1c.t2d.x1e.x2e, z1.t1c.t2d.x1e.x2f, z1.t1c:t2d.x1e.x2g, zl.tlc.t2d.xle.x2h, zl.tlc.t2d.xlf.x2a, zl.tlc.t2d.xlf.x2b, zl.tlc.t2d.xlf.x2c, zl.tlc.t2d.xlf.x2d, zl.tlc.t2d.xlf.x2e, zl.tlc.t2d.xlf.x2f, zl.tlc.t2d.xlf.x2g, z1.t1c.t2d.x1f.x2h, =
zl.tlc.t2d.x1g.x2a, zl.tlc.t2d.xlg.x2b, z1.t1c.t2d.xlg.x2c, zl.tlc.t2d.x1g.x2d, zl.tlc.t2d.xlg.x2e, zl.tlc.t2d.xlg.x2f, zl.tlc.t2d.xlg.x2g, zl.tlc.t2d.xlg.x2h, z1.t1c.t2d.x1h.x2a, zl.tlc.t2d.xlh.x2b, zl.tlc.t2d.xlh.x2c, zl.tlc.t2d.xlh.x2d, zl.tlc.t2d.xlh.x2e, zl.tlc.t2d.xlh.x2f; zl.tlc.t2d.x1h.x2g, zl.tlc.t2d.x1h.x2h, zl.tlc.t2e.xla.x2a, zl.tlc.t2e.xla.x2b, zl.tlc.t2e.xla.x2c, zl.tlc.t2e.xla.x2d, zl.tlc.t2e.xla.x2e, zl.tlc.t2e.xla.x2f, zl.tlc.t2e.xla.x2g, z1.t1c.t2e.x1a.x2h, zl.tlc.t2e.xlb.x2a, zl.tlc.t2e.xlb.x2b, zl.tlc.t2e.xlb.x2c, zl.tlc.t2e.xlb.x2d, zl.tlc.t2e.xlb.x2e, zl.tlc.t2e.xlb.x2f, zl.tlc.t2e.xlb.x2g, zl.tlc.t2e.xlb.x2h, .zl.tlc.t2e.xlc.x2a, zl.tlc.t2e.x1c.x2b, z1.t1c.t2e.x1c.x2c, zl.tlc.t2e.xlc.x2d, zl.tlc.t2e.xlc.x2e, zl.tlc.t2e.xlc.x2f, zl.tlc.t2e.xlc.x2g, zl.tlc.t2e.xlc.x2h, zl.tlc.t2e.x1d.x2a, zl.tlc.t2e.xld.x2b, zl.tlc.t2e.xld.x2c, zl.tlc.t2e.xld.x2d, zl.tlc.t2e.xld.x2e, zl.tlc.t2e.xld.x2f, zl.tlc.t2e.xld.x2g, zl.tlc.t2e.xld.x2h, zi.tlc.t2e.xle.x2a, zl.tlc.t2e.xle.x2b, zl.tlc.t2e.x1e.x2c, zl.tlc.t2e.xle.x2d, zl.tlc.t2e.xle.x2e, zl.tlc.t2e.xle.x2f, zl.tlc.t2e.xle.x2g, zl.tlc.t2e.xle.x2h, zl.tlc.t2e.xlf.x2a, zl.tlc.t2e.xlf.x2b, zl.tlc.t2e.xlf.x2c, zl.tlc.t2e.xlf.x2d, z1.t1c.t2e.x1f.x2e, z1.t1c.t2e.xlf.x2f, zl.tlc.t2e.x1f.x2g, zl.tlc.t2e.xlf.x2h, zl.tlc.t2e.xlg.x2a, zl.tlc.t2e.xlg.x2b, zl.tlc.t2e.xlg:x2c, zl.tlc.t2e.xlg.x2d, zl.tlc.t2e.xlg.x2e, zl.tlc.t2e.xlg.x2f, zl.tlc.t2e.xlg.x2g, zl.tlc.t2e.xlg.x2h, zl.tlc.t2e.xlh.x2a, zl.tlc.t2e.xlh.x2b, zl.tlc.t2e.xlh.x2c, zl.tlc.t2e.xlh.x2d, zl.tlc.t2e.xlh.x2e, zl.tlc.t2e.xlh.x2f, zl.tlc.t2e.xlh.x2g, zl.tlc.t2e_x1h.x2h, zl.tld.t2a.xla.x2a, zl.tld.t2a.xla.x2b, zl.tld.t2a.xla.x2c, zl.tld.t2a.xla.x2d, zl.tld.t2a.xla.x2e, zl.tld.t2a.xla.x2f, zl.tld.t2a.xla.x2g, zl.tld.t2a.xla.x2h, zl.tld.t2a.xlb.x2a, zl.tld.t2a.xlb.x2b, zi.tld.t2a.xlb.x2c, zl.tld.t2a.xlb.x2d, zl.tld.t2a.xlb.x2e, zl.tld.t2a.xlb.x2f, zl.tld.t2a.xlb.x2g, zl.tld.t2a.xlb.x2h, zl.tld.t2a.xlc.x2a, zl.tld.t2a.xlc.x2b, zl.tld.t2a.xlc.x2c, zl.tld.t2a.xlc.x2d, zl.tld.t2a.xlc.x2e, zl.tld.t2a.xlc.x2f, zl.tld.t2a.xlc.x2g, zl.tld.t2a.xlc.x2h, zl.tld.t2a.xld.x2a, zl.tld.t2a.xld.x2b, zl.tld.t2a.x1d.x2c, zl.tld.t2a.xld.x2d, zl.tld.t2a.xld.x2e, zl.tld.t2a.xld.x2f, z1.t1d.t2a.xld.x2g, zl.tld.t2a.xld.x2h, zl.tld.t2a.xle.x2a, zl.tld.t2a.xle.x2b, zl.tld.t2a.x1e.x2c, zl.tld.t2a.xle.x2d, zl.tld.t2a.xle.x2e, zl.tld.t2a.xle.x2f, zl.tld.t2a.xle.x2g, zl.tld.t2a.xle.x2h, zl.tld.t2a.xlf.x2a, zl.tld.t2a.xlf.x2b, zl.tld.t2a.xlf.x2c, zl.tld.t2a.xlf.x2d, zl.tld.t2a.xlf.x2e, zl.tld.t2a.xlf.x2f, zl.tld.t2a.xlf.x2g, zl.tld.t2a.x1f.x2h, zl.tld.t2a.xlg.x2a, zl.tld.t2a.xlg.x2b, zl.tld.t2a:xlg.x2c, zl.tld.t2a.xlg.x2d, zl.tld.t2a.xlg.x2e, zl.tld.t2a.xlg.x2f, zl:tld.t2a.xlg.x2g, zi.tld.t2a.x1g.x2h, zl.tld.t2a.xlh.x2a, zl.tld.t2a.xlh.x2b, zl.tld.t2a.xlh.x2c, zl.tld.t2a.xlh_x2d, zl.tld.t2a.xlh.x2e, zl.tld.t2a.xlh.x2f, zl.tld.t2a.xlh.x2g, zl.tld.t2a.xlh.x2h, zl.tld.t2b.xla.x2a, zl.tld.t2b.xla.x2b,.zl.tld.t2b.xla.x2c, zl.tld.t2b.xla.x2d, z1.t1d.t2b.xla.x2e, zl.tld.t2b.xla.x2f, zl.tld.t2b.xla.x2g, z1.t1d.t2b.xla.x2h, zl.tld.t2b.xlb.x2a, zl.tld.t2b.xlb.x2b, zl.tld.t2b.xlb.x2c, zl.tld.t2b.xlb.x2d, zl.tld.t2b.x1b.x2e, zl.tld.t2b.xlb.x2f; zl.tld.t2b.xlb.x2g, zl.tld.t2b.xlb.x2h, z1.t1d.t2b.xlc.x2a, zl.tld.t2b.xlc.x2b, zl.tld.t2b.xlc.x2c, zl.tld.t2b.xlc.x2d, zl.tld.t2b.x1c.x2e, zl.tld.t2b.xlc.x2f, zi.tld.t2b.xlc.x2g, zl.tld.t2b.xlc.x2h, zl.tld.t2b.x1d.x2a, zl.tld.t2b.xld.x2b, z1.t1d.t2b.xld.x2c, zl.tld.t2b.xld.x2d, zl.tld.t2b.xld.x2e, zi.tld.t2b.xld.x2f, zl.tld.t2b.xld.x2g, zl.tld.t2b.xld.x2h, zl.tld.t2b.xle.x2a, zl.tld.t2b.xle.x2b, zl.tld.t2b.xle.x2c, zl.tld.t2b.xle.x2d, zl.tld.t2b.xle.x2e, zl.tld.t2b.xle.x2f, zl.tld.t2b.x1e.x2g, zl.tld.t2b.xle.x2h, zl.tld.t2b.xlf.x2a, zl.tld.t2b.xlf.x2b, zl.tld.t2b.xlf.x2c, zl.tld.t2b.xlf.x2d, zl.tld.t2b.xlf.x2e, zl.tld.t2b.xlf.x2f, z1.t1d.t2b.xlf.x2g, zl.tld.t2b.xlf.x2h, zl.tld.t2b.xlg.x2a, zl.tld.t2b.xlg.x2b, zl.tld.t2b.xlg.x2c, zl.tld.t2b.x1g.x2d, zl.tld.t2b.xlg.x2e, zl.tld.t2b.x1g.x2f, zl.tld.t2b.xlg.x2g, zl.tld.t2b.xlg.x2h, zl.tld.t2b.xlh.x2a, zl.tld.t2b.xlh.x2b, zl.tld.t2b.xlh.x2c, zl.tld.t2b.x1h.x2d, zl.tld.t2b.x1h.x2e, zl.tld.t2b.xlh.x2f, zl.tld.t2b.x1h.x2g, zl.tld.t2b.xlh.x2h, zl.tld.t2c.x1a.x2a, zl.tld.t2c.xla.x2b, zl.tld.t2c.xla.x2c, zl.tld.t2c.x1a.x2d, z1.t1d.t2c.xla.x2e, zl.tld.t2c:xla.x2f, zl.tld.t2c.xla.x2g, zl.tld.t2c.xla.x2h, zl.tld.t2c.xlb.x2a, zl.tld.t2c.xlb.x2b, zl.tld.t2c.x1b.x2c, z1.t1d.t2c.xlb.x2d, zl.tld.t2c.x1b.x2e, z1.t1d.t2c.xlb.x2f, zl.tld.t2c.xlb.x2g, zl.tld.t2c.xlb.x2h, zl.tld.t2c.x1c.x2a, zl.tld.t2c.xlc.x2b, zl.tld.t2c.xlc.x2c, zl.tld.t2c.xlc.x2d, zl.tld.t2c.xlc.x2e, zl.tld.t2c.xlc.x2f, zl.tld.t2c.xlc.x2g, zl.tld.t2c.x1c.x2h, zl.tld.t2c.xld.x2a, z1.t1d.t2c.xld.x2b, zl.tld.t2c.xld.x2c, zl.tld.t2c.xld.x2d, zl.tld.t2c.xld.x2e, zl.tld.t2c.xld.x2f, zl.tld.t2c.xld.x2g, zl.tld.t2c.x1d.x2h, zl.tld.t2c.xle.x2a, zl.tld.t2c.xle.x2b, zl.tld.t2c.x1e.x2c, zl.tld.t2c.xle.x2d, zl.tld.t2c.xle.x2e, zl.tld.t2c.xle.x2f, zl.tld.t2c.xle.x2g, zl.tld.t2c.xle.x2h, zl.tld.t2c.xlf.x2a, zl.tld.t2c.xlf.x2b, zl.tld.t2c.xlf.x2c, z1.t1d.t2c.x1f.x2d, zl.tld.t2c.xlf.x2e, zl.tld.t2c.xlf.x2f, zl.tld.t2c.xlf.x2g, zl.tld.t2c.xlf.x2h, zl.tld.t2c.xlg.x2a, zl.tld.t2c.xlg.x2b, zl.tld.t2c.xlg.x2c, zl.tld.t2c.xlg.x2d, zl.tld.t2c.xlg.x2e, zl.tld.t2c.xlg.x2f, zl.tld.t2c.x1g.x2g, zl.tld.t2c.xlg.x2h, zl.tld.t2c.xlh.x2a, zl.tld.t2c.xlh.x2b, zl.tld.t2c.xlh.x2c, zl.tld.t2c.xlh.x2d, zl.tld.t2c.xlh.x2e, zl.tld.t2c.x1h.x2f, z1.t1d.t2c.xlh.x2g, zl.tld.t2c.xlh.x2h, zl.tld.t2d.xla.x2a, zl.tld.t2d.xla.x2b, zl.tld.t2d.x1a.x2c, zl.tld.t2d.x1a.x2d, zl.tld.t2d.xla.x2e, zl.tld.t2d.xla.x2f, zl.tld.t2d.xla.x2g, zl.tld.t2d.xla.x2h, zl.tld.t2d.xlb.x2a, zl.tld.t2d.xlb.x2b, zl.tld.t2d.xlb.x2c, zl.tld.t2d.xlb.x2d, zl.tld.t2d.x1b.x2e, zl.tld.t2d.x1b.x2f, zl.tld.t2d.xlb.x2g, zl.tld.t2d.xlb.x2h, zl.tld.t2d.x1c.x2a, zl.tld.t2d.xlc.x2b, zl.tld.t2d.xlc.x2c, zl.tld.t2d.x1c.x2d, zl.tld.t2d.xlc.x2e, zl.tld.t2d.xlc.x2f, zl.tld.t2d.xlc.x2g, zl.tld.t2d.xlc.x2h, zl.tld.t2d.xld.x2a, zl.tld.t2d.xld.x2b, zl.tld.t2d.xld.x2c, zl.tld.t2d.x1d.x2d, zl.tld.t2d.xld.x2e, zl.tld.t2d.xld.x2f, zl.tld.t2d.xld.x2g, zl.tld.t2d.xld.x2h, zl.tld.t2d.xle.x2a, zl.tld.t2d.xle.x2b, zl.tld.t2d.xle.x2c, zl.tld.t2d.xle.x2d, zl.tld.t2d.xle.x2e, zl.tld.t2d.xle.x2f, zl.tld.t2d.x1e.x2g, zl.tld.t2d.xle.x2h, zl.tld.t2d.xlf.x2a, zl.tld.t2d.x1f.x2b, zl.tld.t2d.xlf.x2c, zl.tld.t2d.xlf.x2d, zl.tld.t2d.xlf.x2e, zl.tld.t2d.xlf.x2f, zl.tld.t2d.xlf.x2g, zl.tld.t2d.xlf.x2h, zl.tld.t2d.xlg.x2a, zl.tld.t2d.xlg.x2b, zl.tld.t2d.xlg.x2c, zl.tld.t2d.xlg.x2d, zl.tld.t2d.xlg.x2e, zl.tld.t2d.xlg.x2f, zl.tld.t2d.xlg.x2g, zl.tld.t2d.xlg.x2h, zl.tld.t2d.xlh.x2a, zl.tld.t2d.xlh.x2b, zl.tld.t2d.xlh.x2c, zl.tld.t2d.xlh.x2d, zl.tld.t2d.xlh.x2e, zl.tld.t2d.xlh.x2f, zl_tld.t2d.x1h.x2g, z1.t1d.t2d.xlh.x2h, zl.tld.t2e.x1a.x2a, zl.tld.t2e.xla.x2b, zl.tld.t2e.xla.x2c, zl.tld.t2e.xla.x2d, zl.tld.t2e.xla.x2e, zl.tld.t2e.xla.x2f, zl.tld.t2e.xla.x2g, zl.tld.t2e.xla.x2h, zl.tld.t2e.xlb.x2a, zl.tld.t2e.x1b.x2b, zl.tld.t2e.xlb.x2c, zi.tld.t2e.xlb.x2d, zl.tld.t2e.xlb.x2e, zl.tld.t2e.xlb.x2f, zl.tld.t2e.xlb.x2g, zl.tld.t2e.xlb.x2h, zl.tld.t2e.xlc.x2a, zl.tld.t2e.xlc.x2b, zl.tld.t2e.xlc.x2c, z1.tld.t2e.xlc.x2d, zl.tld.t2e.xlc.x2e, zl.tld.t2e.xlc.x2f, zl.tld.t2e.xlc.x2g, zl.tld.t2e.xlc.x2h, zl.tld.t2e.x1d.x2a, z1.t1d.t2e.x1d.x2b, zl.tld.t2e.xld.x2c, zl.tld.t2e.xld.x2d, zl.tld.t2e.x1d.x2e, zl.tld.t2e.xld.x2f, zl.tld.t2e.xld.x2g, zl.tld.t2e.xld.x2h, zl.tld.t2e.xle.x2a, z1.t1d.t2e.x1e.x2b, zl.tld.t2e.xle.x2c, zl.tld.t2e.xle.x2d, zl.tld.t2e.xle.x2e, zl.tld.t2e.xle.x2f, zl.tld.t2e.xle.x2g, zl.tld.t2e.xle.x2h, zl.tld.t2e.xlf.x2a, zl.tld.t2e.xlf.x2b, zl.tld.t2e.xlf.x2c, zl.tld.t2e.xlf.x2d, zl.tld.t2e.xlf.x2e, zl.tld.t2e.xlf.x2f, zl.tld.t2e.xlf.x2g, zl.tld.t2e.xlf.x2h, zl.tld.t2e.xlg.x2a, zl.tld.t2e.xlg.x2b, zl.tld.t2e.xlg.x2c, zl.tld.t2e.xlg.x2d, zl.tld.t2e.xlg.x2e, zl.tld.t2e.xlg.x2f, zl.tld.t2e.x1g.x2g, zl.tld.t2e.xlg.x2h, zl.tld.t2e.x1h.x2a, zl.tld.t2e.xlh.x2b, zl.tld.t2e.xlh.x2c, zl.tld.t2e.xlh.x2d, zl.tld.t2e.x1h.x2e, z1.t1d.t2e.xlh.x2f, zl.tld.t2e.xlh.x2g, zl.tld.t2e.xlh.x2h, zl.tle.t2a.xla.x2a, zl.tle.t2a.xla.x2b, zl.tle.t2a.xla.x2c, zl.tle.t2a.xla.x2d, zl.tle.t2a.xla.x2e, zl.tle.t2a.xla.x2f, zl.tle.t2a.xla.x2g, zl.tle.t2a.xla.x2h, zl.tle.t2a.xlb.x2a, zl.tle.t2a.xlb.x2b, zl.tle.t2a.xlb.x2c, zl.tle.t2a.x1b.x2d, z1.t1e.t2a.x1b.x2e, zl.tle.t2a.xlb.x2f, zl.tle.t2a.xlb.x2g, z1.t1e.t2a.xlb.x2h, zl.tle.t2a.xlc.x2a, zl.tle.t2a.xlc.x2b, zl.tle.t2a.xlc.x2c, zl.tle.t2a.xlc.x2d, zl.tle.t2a.xlc.x2e, zl.tle.t2a.xlc.x2f, zl.tle.t2a.xlc.x2g, zl.tle.t2a.xlc.x2h, zl.tle.t2a.x1d.x2a, zl.tle.t2a.xld.x2b, zl.tle.t2a.xld.x2c, zl.tle.t2a.xld.x2d, zl.tle.t2a.xld.x2e, zl.tle.t2a.xld.x2f, zl.tle.t2a.xld.x2g, zl.tle.t2a.xld.x2h, zl.tle.t2a.xle.x2a, zl.tle.t2a.xle.x2b, zl.tle.t2a.xle.x2c, zl.tle.t2a.xle.x2d, zl.tle.t2a.xle.x2e, zl.tle.t2a.xle.x2f, zl.tle.t2a.xle.x2g, zl.tle.t2a.xle.x2h, zl.tle.t2a.xlf.x2a; zl.tle.t2a.xlf.x2b, zl.tle.t2a.xlf.x2c, zl.tle.t2a.xlf.x2d, zl.tle.t2a.x1f.x2e, zl.tle.t2a.xlf.x2f, zl.tle.t2a.xlf.x2g, zl.tle.t2a.xlf.x2h, zl.tle.t2a.xlg.x2a, zl.tle.t2a.xlg.x2b, zl.tle.t2a.xlg.x2c, zl_tle.t2a.x1g.x2d, zl.tle.t2a.xlg.x2e, zl.tle.t2a.xlg.x2f, zl.tle.t2a.xlg.x2g, zl.tle.t2a.xlg.x2h, z1.t1e.t2a.x1h.x2a, zl.tle.t2a.xlh.x2b, zl.tle.t2a.xlh.x2c, zl.tle.t2a.xlh.x2d, zl.tle.t2a.x1h.x2e, zl.tle.t2a.xlh.x2f, zl.tle.t2a.xlh.x2g, zl.tle.t2a.xlh.x2h, z1.t1e.t2b.xla.x2a, zl.tle.t2b.x1a.x2b, 'zl.tle.t2b.x1a.x2c, zl.tle.t2b.xla.x2d, zl.tle.t2b.xla.x2e, zl.tle.t2b.x1a.x2f, zl.tle.t2b.xla.x2g, zl.tle.t2b.xla.x2h, zl.tle.t2b.x1b.x2a, zl.tle.t2b.xlb.x2b, zl.tle.t2b.xlb_x2c, zl.tle.t2b.xlb.x2d, zl.tle.t2b.xlb.x2e, zl.tle.t2b.xlb.x2f, zl.tle.t2b.xlb.x2g, zl.tle.t2b.xlb.x2h, z1.t1e.t2b.x1c.x2a, zl.tle.t2b.xlc.x2b, z1.t1e.t2b.x1c.x2c, zl.tle.t2b.xlc.x2d, zl.tle.t2b.x1c.x2e, zl.tle.t2b.xlc.x2f, zl.tle.t2b.x1c.x2g, z1.t1e.t2b.x1c.x2h, zl.tle.t2b.xld.x2a, zl.tle.t2b.xld.x2b, zl.tle.t2b.xld.x2c, zl.tle.t2b.xld.x2d, zl.tle.t2b.xld.x2e, zl.tle.t2b.xld.x2f, zl.tle.t2b.xld.x2g, zl.tle.t2b.xld.x2h, z1.t1e.t2b.xle.x2a, zl.tle.t2b.xle.x2b, zl.tle.t2b.xle.x2c, zl.tle.t2b.xle.x2d, zl.tle.t2b.xle.x2e, zl.tle.t2b.xle.x2f, zl.tle.t2b.xle.x2g, zl.tle.t2b.xle.x2h, zl.tle.t2b.xlf.x2a, zl.tle.t2b.xlf.x2b, zl.tle.t2b.xlf.x2c, zl.tle.t2b.xlf.x2d, zl.tle.t2b.x1f.x2e, zl.tle.t2b.x1f.x2f, zl.tle.t2b.xlf.x2g, zl.tle.t2b.xlf.x2h, zl.tle.t2b.xlg.x2a, zl.tle.t2b.xlg.x2b, z1.t1e.t2b.xlg.x2c, zl.tle.t2b.xlg.x2d, zl.tle.t2b.xlg.x2e, zl.tle.t2b.xlg.x2f, zl.tle.t2b.xlg.x2g, zl_tle.t2b.xlg.x2h, z1.t1e.t2b.x1h.x2a, zl.tle.t2b.xlh.x2b, zi.tle.t2b.x1h.x2c, zl.tle.t2b.xlh.x2d, zl.tle.t2b.xlh.x2e, zl.tle.t2b.xlh.x2f, zl.tle.t2b.xlh.x2g, zl.tle.t2b.xlh.x2h, zl.tle.t2c.xla.x2a, zl.tle.t2c.x1a.x2b, zl.tle.t2c.xla.x2c, z1.t1e.t2c.xla.x2d, zl.tle.t2c.xla.x2e, zl.tle.t2c.x1a.x2f, zl.tle.t2c.xla.x2g, z1.t1e.t2c.xla_x2h, zl.tle.t2c.xlb.x2a, zl.tle.t2c.xlb.x2b, zl.tle.t2c.xlb.x2c, zl.tle.t2c.xlb.x2d, zl.tle.t2c.xlb.x2e, zl.tle.t2c.xlb.x2f, zl.tle.t2c.xlb.x2g, zl.tle.t2c.xlb.x2h, zl.tle.t2c.xlc.x2a, zl.tle.t2c.xlc.x2b, zl.tle.t2c.xlc.x2c, zi.tle.t2c.xlc.x2d, zl.tle.t2c.xlc.x2e, zl.tle.t2c.xlc.x2f, zl.tle.t2c.xlc.x2g, zl.tle.t2c.xlc.x2h, zl.tle.t2c.xld.x2a, zl.tle.t2c.xld.x2b, zl.tle.t2c.xld.x2c, zl.tle.t2c.xld.x2d, zl.tle.t2c.xld.x2e, zl.tle.t2c.xld.x2f, zl.tle.t2c.xld.x2g, zl.tle.t2c.xld.x2h, zl.tle.t2c.xle.x2a, zl.tle.t2c.xle.x2b, zl.tle.t2c.xle.x2c, zl.tle.t2c.xle.x2d, zl.tle.t2c.x1e.x2e, zl.tle.t2c.xle.x2f, zl.tle.t2c.xle.x2g, zl.tle.t2c.xle.x2h, zl.tle.t2c.xlf.x2a, zl.tle.t2c.xlf.x2b, zl.tle.t2c.xlf.x2c, zl.tle.t2c.xlf.x2d, zi.tle.t2c.x1f.x2e, zl.tle.t2c.xlf.x2f, z1.t1e.t2c.xlf.x2g, zl.tle.t2c.xlf.x2h, zl.tle.t2c.xlg.x2a, zl.tle.t2c.xlg.x2b, zl.tle.t2c.xlg.x2c, zl.tle.t2c.xlg.x2d, z1.t1e.t2c.xlg.x2e, zl.tle.t2c.xlg.x2f, zl.tle.t2c.xlg.x2g, zl.tle.t2c.xlg.x2h, zl.tl.e.t2c.xlh.x2a, z1.t1e.t2c.x1h.x2b, zl.tle.t2c.xlh.x2c, zl.tle.t2c.xlh.x2d, zl.tle.t2c.xlh.x2e, zl.tle.t2c.xlh.x2f, zl.tle.t2c.xlh.x2g, zl.tle.t2c.xlh.x2h, zl.tle.t2d.xla.x2a, zl.tle.t2d.xla.x2b, zl.tle.t2d.xla.x2c, zl.tle.t2d.xla.x2d, zl.tle.t2d.xla.x2e, zl.tle.t2d.xla.x2f, zl.tle.t2d.xla.x2g, zl.tle.t2d.xla.x2h, zl.tle.t2d.xlb.x2a, zl.tle.t2d.xlb.x2b, zl.tle.t2d.xlb.x2c, zl.tle.t2d.xlb.x2d, zl.tle.t2d.xlb.x2e, zl.tle.t2d.xlb.x2f, zl.tle.t2d.xlb.x2g, zl.tle.t2d.x1b.x2h, zl.tle.t2d.xlc.x2a, zl.tle.t2d.xlc.x2b, zl.tle.t2d.xlc.x2c, zl.tle.t2d.xlc.x2d, zl.tle.t2d.xlc.x2e, zl.tle.t2d.xlc.x2f, zl.tle.t2d.x1c.x2g, zl.tle.t2d.xic.x2h, zl.tle.t2d.xld.x2a, zl.tle.t2d.xld.x2b, zl.tle.t2d.x1d.x2c, z1.t1e.t2d.x1d.x2d, zl.tle.t2d.xld.x2e, zl.tle.t2d.xld.x2f, zl.tle.t2d.xld.x2g, zl.tle.t2d.xld.x2h, zl.tle.t2d.xle.x2a, zl.tle.t2d.xle.x2b, zl.tle.t2d.xle.x2c, zl.tle.t2d.xle.x2d, zl.tle.t2d.xle.x2e, zl.tle.t2d.xle.x2f, zl.tle.t2d.xle.x2g, zl.tle.t2d.xle.x2h, zl.tle.t2d.x1f.x2a, zl.tle.t2d.xlf.x2b, zl.tle.t2d.xlf.x2c, zl.tle.t2d.xlf.x2d, zl.tle.t2d.xlf.x2e, zl.tle.t2d.xlf.x2f, zi.tle.t2d.xlf.x2g, zl.tle.t2d.xlf.x2h, zl.tle.t2d.xlg.x2a, z1.t1e.t2d.x1g.x2b, zl.tle.t2d.xlg.x2c, zl.tle.t2d.xlg.x2d, zl.tle.t2d.xlg.x2e, zl.tle.t2d.xlg.x2f, zl.tle.t2d.xlg.x2g, zl.tle.t2d.xlg.x2h, zl.tle.t2d.xlh.x2a, zl.tle.t2d.xlh.x2b, zl.tle.t2d.xlh.x2c, zl.tle.t2d.xlh.x2d, zl.tle.t2d.xlh.x2e, zl.tle.t2d.xlh.x2f, zl.tle.t2d.xlh.x2g, zl.tle.t2d.xlh.x2h, zl.tle.t2e.xla.x2a, zl.tle.t2e.xla.x2b, zl.tle.t2e.xla.x2c, zl.tle.t2e.xla.x2d, z1.t1e.t2e.xla.x2e, zl.tle.t2e.xla.x2f, zl.tle.t2e.xla.x2g, zl.tle.t2e.x1a.x2h, zl.tle.t2e.xlb.x2a, zl.tle.t2e.xlb.x2b, zl.tle.t2e.xlb.x2c, zl.tle.t2e.xlb.x2d, zl.tle.t2e.xlb.x2e, zl.tle.t2e.xlb.x2f, zl.tle.t2e.xlb.x2g, zl.tle.t2e.xlb.x2h, zl.tle.t2e.xlc.x2a, zi.tle.t2e.xlc.x2b, zi.tle.t2e.xlc.x2c, zl.tle.t2e.xlc.x2d, zl.tle.t2e.xlc.x2e, zl.tle.t2e.xlc.x2f, zl.tle.t2e.xlc.x2g, zl.tle.t2e.xlc.x2h, zl.tle.t2e.xld.x2a, z1.t1e.t2e.x1d.x2b, zl.tle.t2e.xld.x2c, zl.tle.t2e.xld.x2d, zl.tle.t2e.xld.x2e, zl.tle.t2e.xld.x2f, zl.tle.t2e.xld.x2g, zl.tle.t2e.xld.x2h, zl.tle.t2e.xle.x2a, zl.tle.t2e.xle.x2b, zl.tle.t2e.x1e.x2c, z1.t1e.t2e.xle.x2d, zl.tle.t2e.xle.x2e, zl.tle.t2e.xle.x2f, zl.tle.t2e.xle.x2g, zi.tle.t2e.xle.x2h, zl.tle.t2e.xlf.x2a, zl.tle.t2e.xlf.x2b, zl.tle.t2e.xlf.x2c, zl.tle.t2e.xlf.x2d, zl.tle.t2e.xlf.x2e, zl.tle.t2e.x1f.x2f, zl.tle.t2e.xlf.x2g, zl.tle.t2e.x1f.x2h, zl.tle.t2e.xlg.x2a, zl.tle.t2e.xlg.x2b, zl.tle.t2e.x1g.x2c, zl.tle.t2e.xlg.x2d, zl.tle.t2e.x1g.x2e, zl.tle.t2e.x1g.x2f, zl.tle.t2e.xlg.x2g, zl.tle.t2e.xlg.x2h, zl.tle.t2e.xlh.x2a, zl.tle.t2e.xlh.x2b, zl.tle.t2e.xlh.x2c, zl.tle.t2e.xlh.x2d, zl.tle.t2e.xlh.x2e, zi.tle:t2e.xlh.x2f, zl.tle.t2e.xlh.x2g, zl.tle.t2e.xlh.x2h, z2.tla.t2a.xla.x2a, z2.tla.t2a.xla.x2b, z2.tla.t2a.xla.x2c, z2.tla.t2a.xla.x2d, z2.tla.t2a.xla.x2e, z2.t1a.t2a.x1a.x2f, z2.tla.t2a.xla.x2g, z2.tla.t2a.xla.x2h, z2.tla.t2a.xlb.x2a, z2.tla.t2a.xlb.x2b, z2.tla.t2a.xlb.x2c, z2.tla.t2a.xlb.x2d, z2.tla.t2a.xlb.x2e, z2.tla.t2a.xlb.x2f, z2.tla.t2a.xlb.x2g, z2.tla.t2a.xlb.x2h, z2.tla.t2a.xlc.x2a, z2.tla.t2a.xlc.x2b, z2.t1a.t2a.xlc.x2c, z2.tla.t2a.xlc.x2d, z2.tla.t2a.xlc.x2e, z2.tla.t2a.xlc.x2f, z2.tla.t2a.xlc.x2g, z2.t1a.t2a.x1c.x2h, z2.tla.t2a.xld.x2a, z2.tla.t2a.xld.x2b, z2.tla.t2a.xld.x2c, z2.tla.t2a.xld.x2d, z2.tla.t2a.xld.x2e, z2.tla.t2a.xld.x2f, z2.tla.t2a.xld.x2g, z2.tla.t2a.xld.x2h, z2.tla.t2a.xle.x2a, z2.tla.t2a.xle.x2b, z2.tla.t2a.xle.x2c, z2.tla.t2a.xle.x2d, z2.tla.t2a.xle.x2e, z2.tla.t2a.xle.x2f, z2.tla.t2a.xle.x2g, z2.tla.t2a.xle.x2h, z2.tla.t2a.xlf.x2a, z2.tla.t2a.xlf.x2b, z2.tla.t2a.xlf.x2c, z2.tla.t2a.xlf.x2d, z2.tla.t2a.xlf.x2e, z2.tla.t2a.xlf.x2f, z2.tla.t2a.xlf.x2g, z2.tla.t2a.xlf.x2h, z2.tla.t2a.xlg.x2a, z2.tla.t2a.xlg.x2b, z2.tla.t2a.xlg.x2c, z2.tla.t2a.x1g.x2d, z2.tla.t2a.xlg.x2e, z2.tla.t2a.xlg.x2f, z2.tla.t2a.xlg.x2g, z2.tla.t2a.xlg.x2h, z2.tla.t2a.xlh.x2a, z2.tla.t2a.xlh.x2b, z2.tla.t2a.xlh.x2c, z2.tla.t2a.xlh.x2d, z2.tla.t2a.xlh.x2e, z2.tla.t2a.xlh.x2f, z2.tla.t2a.xlh.x2g, z2.tla.t2a.xlh.x2h, z2.tla.t2b.xla.x2a, z2.tla.t2b.xla.x2b, z2.tla.t2b.xla.x2c, z2.tla.t2b.xla.x2d, z2.tla.t2b.xla.x2e, z2.tla.t2b.xla.x2f, z2.tla.t2b.xla.x2g, z2.tla.t2b.xla.x2h, z2.tla.t2b.xlb.x2a, z2.tla.t2b.xlb.x2b, z2.tla.t2b.xlb.x2c, z2.tla.t2b.xlb.x2d, z2.tla.t2b.xlb.x2e, z2.tla.t2b.xlb.x2f, z2.tla.t2b.xlb.x2g, z2.tla.t2b.xlb.x2h, .133 z2.tla.t2b.xlc.x2a, z2.tla.t2b.xlc.x2b, z2.tla.t2b.xlc.x2c, z2.tla.t2b.xlc.x2d, z2.tla.t2b.xlc.x2e, z2.tla.t2b.xlc.x2f, z2.tla.t2b.xlc.x2g, z2.tla.t2b.xlc.x2h, z2.tla.t2b.xld.x2a, z2.tla.t2b.xld.x2b, z2.tla.t2b.xld.x2c, z2.tla.t2b.xld.x2d, z2.tla.t2b.xld.x2e, z2.tla.t2b.xld.x2f, z2.tla.t2b.xld.x2g, z2.tla.t2b.xld.x2h, z2.tla.t2b.xle.x2a, z2.tla.t2b.xle.x2b, z2.tla.t2b.xle.x2c, z2.tla.t2b.xle.x2d, z2.tla.t2b.xle.x2e, z2.tla.t2b.xle.x2f, z2.t1a.t2b.x1e.x2g, z2.tla.t2b.xle.x2h, z2.tla.t2b.xlf.x2a, z2.tla.t2b.xlf.x2b, z2.tla.t2b.xlf.x2c, z2.tla.t2b.xlf.x2d, z2.tla.t2b.xlf.x2e, z2.tla.t2b.xlf.x2f, z2.tla.t2b.xlf.x2g, z2.tla.t2b.xlf.x2h, z2.tla.t2b.xlg.x2a, z2.tla.t2b.xlg.x2b, z2.tla.t2b.xlg.x2c, z2.tla.t2b.xlg.x2d, z2.tla.t2b.xlg.x2e, z2.tla.t2b.xlg.x2f, z2.tla.t2b.xlg.x2g, z2.tla.t2b.xlg.x2h, z2.tla.t2b.xlh.x2a, z2.tla.t2b.xlh.x2b, z2.tla.t2b.xlh.x2c, z2.tla.t2b.xlh.x2d, z2.t1a.t2b.xlh.x2e, z2.tla.t2b.x1h.x2f, z2.tla.t2b.xlh.x2g, z2.tla.t2b.xlh.x2h, z2.tla.t2c.xla.x2a, z2.tla.t2c.xla.x2b, z2.tla.t2c.xla.x2c, z2.tla.t2c.xla.x2d, z2.tla.t2c.xla.x2e, z2.tla.t2c.xla.x2f, z2.tla.t2c.xla.x2g, z2.tla.t2c.xla.x2h, z2.tla.t2c.xlb.x2a, z2.tla.t2c.xlb.x2b, z2.tla.t2c.xlb.x2c, z2.tla.t2c.xlb.x2d, z2.tla.t2c.xlb.x2e, z2.tla.t2c.xlb.x2f, z2.tla.t2c.xlb.x2g, z2.tla.t2c.xlb.x2h, z2.tla.t2c.xlc.x2a, z2.tla.t2c.xlc.x2b, z2.tla.t2c.xlc.x2c, z2.tla.t2c.xlc.x2d, z2.tla.t2c.xlc.x2e, z2.tla.t2c.xlc.x2f, z2.tla.t2c.xlc.x2g, z2.tla.t2c.xlc.x2h, z2.tla.t2c.,xld.x2a, z2.tla.t2c.xld.x2b, z2.tla.t2c.xld.x2c, z2.tla.t2c.xld.x2d, z2.tla.t2c.xld.x2e, z2.tla.t2c.xld.x2f, z2.tla.t2c.xld.x2g, z2.tla.t2c.xld.x2h, z2.tla.t2c.xle.x2a, z2.tla.t2c.xle.x2b, z2.tla.t2c.xle.x2c, z2.tla.t2c.xle.x2d, z2.tla.t2c.xle.x2e, z2.tla.t2c.xle.x2f, z2.tla.t2c.xle.x2g, z2.tla.t2c.xle.x2h, z2.tla.t2c.xlf.x2a, z2.tla.t2c.x1f.x2b, z2.tla.t2c.xlf.x2c, z2.tla.t2c.xlf.x2d, z2.tla.t2c.xlf.x2e, z2.tla.t2c.xlf.x2f; z2.tla.t2c.xlf.x2g, z2.tla.t2c.xlf.x2h, z2.tla.t2c.xlg.x2a, z2.tla.t2c.xlg.x2b, z2.tla.t2c.xlg.x2c, z2.tla.t2c.xlg.x2d, z2.t1a.t2c.xlg.x2e, z2.tla.t2c.xlg.x2f, z2.tla.t2c.xlg.x2g, z2.tla.t2c.xlg.x2h, z2.t1a.t2c.xlh.x2a, z2.tla.t2c.xlh.x2b, z2.tla.t2c.xlh.x2c, z2.tla.t2c.xlh.x2d, z2.tla.t2c.xlh.x2e, z2.tla.t2c.xlh.x2f, z2.tla.t2c.xlh.x2g, z2.tla.t2c.xlh.x2h, z2.tla.t2d.xla.x2a, z2.tla.t2d.xla.x2b, z2.tla.t2d.xla.x2c, z2.t1a.t2d.x1a.x2d, z2.tla.t2d.xla.x2e, z2.tla.t2d.x1a.x2f, z2.tla.t2d.xla.x2g, z2.tla.t2d.xla.x2h, z2.t1a.t2d.x1b.x2a, z2.tla.t2d.xlb.x2b, z2.tla.t2d.xlb.x2c, z2.tla.t2d.xlb.x2d, z2.tla.t2d.xlb.x2e, z2.tla.t2d.xlb.x2f, z2.tla.t2d.xlb.x2g, z2.tla.t2d.xlb.x2h, z2.tla.t2d.xlc.x2a, z2.tla.t2d.xlc.x2b, z2.tla.t2d.xlc.x2c, z2.tla.t2d.xlc.x2d, z2.tla.t2d.xlc.x2e, z2.tla.t2d.xlc.x2f, z2.tla.t2d.xlc.x2g, z2.tla.t2d.xlc.x2h, z2.tla.t2d.xld.x2a, z2.tla.t2d.xld.x2b, z2.tla.t2d.xld.x2c, z2.tla.t2d.xld.x2d, z2.tla.t2d.xld.x2e, z2.tla.t2d.xld.x2f, z2.tla.t2d.xld.x2g, z2.tla.t2d.xld.x2h, z2.tla.t2d.xle.x2a, z2.t1a.t2d.x1e.x2b, z2.tla.t2d.xle.x2c, z2.t1a.t2d.xle.x2d, z2.tla.t2d.xle.x2e, z2.t1a.t2d.x1e.x2f, z2.tla.t2d.xle.x2g, z2.tla.t2d.xle.x2h, z2.tla.t2d.xlf.x2a, z2.tla.t2d.xlf.x2b, z2.t1a.t2d.xlf.x2c, z2.tla.t2d.xlf.x2d, z2.tla.t2d.xlf.x2e, z2.tla.t2d.xlf.x2f, z2.tla.t2d.xlf.x2g, z2.tla.t2d.xlf.x2h, z2.tla.t2d.xlg.x2a, z2.tla.t2d.xlg.x2b, z2.tla.t2d.xlg.x2c, z2.tla.t2d.xlg.x2d, z2.tla.t2d.xlg.x2e, z2.tla.t2d.xlg.x2f, z2.tla.t2d.xlg.x2g, z2.tla.t2d.xlg.x2h, z2.tla.t2d.xlh.x2a, z2.tla.t2d.xlh.x2b, z2.t1a.t2d.xlh.x2c, z2.tla.t2d.xlh.x2d, z2.tla.t2d.xlh.x2e, z2.tla.t2d.xlh.x2f, z2.tla.t2d.xlh.x2g, z2.tla.t2d.xlh.x2h, z2.tla.t2e.x1a.x2a, z2.tla.t2e.xla.x2b, z2.tla.t2e.xla.x2c, z2.tla.t2e.xla.x2d, z2.tla.t2e.xla.x2e, z2.tla.t2e.xla.x2f, z2.tla.t2e.xla.x2g, z2.tla.t2e.xla.x2h, z2.tla.t2e.xlb.x2a, z2.tla.t2e.xlb.x2b, z2.t1a.t2e.xlb.x2c, z2.tla.t2e.xlb.x2d, z2.t1a.t2e.xlb.x2e, z2.tla.t2e.xlb.x2f, z2.tla.t2e.xlb.x2g, z2.tla.t2e.xlb.x2h, z2.tla.t2e.xlc.x2a, z2.tla.t2e.xlc.x2b, z2.tla.t2e.xlc.x2c, z2.tla.t2e.xlc.x2d, z2.tla.t2e.xlc.x2e, z2.tla.t2e.xlc.x2f, z2.tla.t2e.xlc.x2g, z2.tla.t2e.xlc.x2h, z2.tla.t2e.xld.x2a, z2.t1a.t2e.xld.x2b, z2.tla.t2e.xld.x2c, z2.tla.t2e.xld.x2d, z2.tla.t2e.xld.x2e, z2.tla.t2e.xld.x2f, z2.tla.t2e.xld.x2g, z2.tla.t2e.xld.x2h, z2.tla.t2e.xle.x2a, z2.tla.t2e.xle.x2b, z2.tla.t2e.xle.x2c, z2.tla.t2e.xle.x2d, z2.tla.t2e.xle.x2e, z2.tla.t2e.xle.x2f, z2.tla.t2e.xle.x2g, z2.tla.t2e.xle.x2h, z2.tla.t2e.xlf.x2a, z2.tla.t2e.xlf.x2b, z2.tla.t2e.xlf.x2c, z2.tla.t2e.xl'f.x2d, z2.tla.t2e.xlf.x2e, z2.tla.t2e.xlf.x2f, z2.tla.t2e.xlf.x2g, z2.tla.t2e.xlf.x2h, z2.tla.t2e.xlg.x2a, z2.tla.t2e:xlg.x2b, z2.tla.t2e.xlg.x2c, z2.tla.t2e.xlg.x2d, z2.tla.t2e.xlg.x2e, z2.tla.t2e.xlg.x2f, z2.tla.t2e.xlg.x2g, z2.tla.t2e.xlg.x2h, z2.tla.t2e.xlh.x2a, z2.tla.t2e.xlh.x2b, z2.tla.t2e.xlh.x2c, z2.tla.t2e.xlh.x2d, z2.tla.t2e.xlh.x2e, z2.tla.t2e.xlh.x2f, z2.tla.t2e.xlh.x2g, z2.tla.t2e.xlh.x2h, z2.tlb.t2a.xla.x2a, z2.tlb.t2a.xla.x2b, z2.tlb.t2a.xla.x2c, z2.tlb.t2a.xla.x2d, z2.tlb.t2a.xla.x2e, z2.tlb.t2a.xla.x2f, z2.tlb.t2a.xla.x2g, z2.tlb.t2a.xla.x2h, z2.tlb.t2a.xlb.x2a, z2.tlb.t2a.xlb.x2b, z2.tlb.t2a.xlb.x2c, z2.tlb.t2a.xlb.x2d, z2.tlb.t2a.xlb.x2e, z2.tlb.t2a.xlb.x2f, z2.tlb.t2a.xlb.x2g, z2.tlb.t2a.xlb.x2h, z2.tlb.t2a.xlc.x2a, z2.tlb.t2a.xlc.x2b, z2.t1b.t2a.x1c.x2c, z2.tlb.t2a.xlc.x2d, z2.tlb.t2a.xlc.x2e, z2.tlb.t2a.xlc.x2f, z2.tlb.t2a.xlc.x2g, z2.tlb.t2a.xlc.x2h, z2.tlb.t2a.xld.x2a, z2.tlb.t2a.xld.x2b, z2.tlb.t2a.xld.x2c, z2.tlb.t2a.xld.x2d, z2.tlb.t2a.xld.x2e, z2.tlb.t2a.xld.x2f, z2.tlb.t2a.xld.x2g, z2.tlb.t2a.xld.x2h, z2.tlb.t2a.xle.x2a, z2.tlb.t2a.xle.x2b, z2.tlb.t2a.xle.x2c, z2.tlb.t2a.xle.x2d, z2.tlb.t2a.xle.x2e, z2.tlb.t2a.x1e.x2f, z2.tlb.t2a.xle.x2g, z2.tlb.t2a.x1e.x2h, z2.tlb.t2a.xlf.x2a, z2.tlb.t2a.xlf.x2b, z2.tlb.t2a.xlf.x2c, z2.tlb.t2a.xlf.x2d, z2.tlb.t2a.xlf.x2e, z2.tlb.t2a.xlf.x2f, z2.tlb.t2a.xlf.x2g, z2.tlb.t2a.xlf.x2h, z2.tlb.t2a.xlg.x2a, z2.tlb.t2a.xlg.x2b, z2.tlb.t2a.xlg.x2c, z2.tlb.t2a.xlg.x2d, z2.tlb.t2a.xlg.x2e, z2.tlb.t2a.xlg.x2f, z2.tlb.t2a.xlg.x2g, z2.t1b.t2a.xlg.x2h, z2.tlb.t2a.xlh.x2a, z2.tlb.t2a.xlh.x2b, z2.tlb.t2a.xlh.x2c, z2.tlb.t2a.xlh.x2d, z2.tlb.t2a.xlh.x2e, z2.tlb.t2a.xlh.x2f, z2.tlb.t2a.xlh.x2g, z2.tlb.t2a.xlh.x2h, z2.tlb.t2b.xla.x2a, z2.tlb.t2b.xla.x2b, z2.tlb.t2b.xla.x2c, z2.tlb.t2b.xla.x2d, z2.tlb.t2b.xla.x2e, z2.tlb.t2b.xla.x2f, z2.tlb.t2b.xla.x2g, z2.tlb.t2b.xla.x2h, z2.tlb.t2b.xlb.x2a, z2.tlb.t2b.xlb.x2b, z2.tlb.t2b.xlb.x2c, z2.tlb.t2b.xlb.x2d, z2.t1b.t2b.x1b.x2e, z2.tlb.t2b.xlb.x2f, z2.tlb.t2b.xlb.x2g, z2.tlb.t2b.xlb.x2h, z2.tlb.t2b.xlc.x2a, z2.tlb.t2b.xlc.x2b, z2.tlb.t2b.xlc.x2c, z2.tlb.t2b.xlc.x2d, z2.tlb.t2b.xlc.x2e, z2.tlb.t2b.xlc.x2f, z2:tlb.t2b.x1c.x2g, z2.tlb.t2b.xlc.x2h, z2.tlb.t2b.x1d.x2a, z2.tlb.t2b.xld.x2b, z2.tlb.t2b.xld.x2c, z2.t1b.t2b.x1d.x2d, z2.tlb.t2b.xld.x2e, z2.tlb.t2b.xld.x2f, z2.tlb.t2b.xld.x2g, z2.tlb.t2b.xld.x2h, z2.tlb.t2b.xle.x2a, z2.tlb.t2b.xle.x2b, z2.tlb.t2b.xle.x2c, z2.tlb.t2b.xle.x2d, z2.tlb.t2b.xle.x2e, z2.tlb.t2b.xle.x2f, z2.tlb.t2b.xle.x2g, z2.tlb.t2b.xle.x2h, z2.tlb.t2b.xlf.x2a, z2.tlb.t2b.xlf.x2b, z2.tlb.t2b.xlf.x2c, z2.tlb.t2b.xlf.x2d, z2.tlb.t2b.xlf.x2e, z2.tlb.t2b.xlf.x2f, z2.tlb.t2b.xlf.x2g, z2.tlb.t2b.xlf.x2h, z2.tlb.t2b.xlg.x2a, z2.tlb.t2b.xlg.x2b, z2.tlb.t2b.xlg.x2c, z2.tlb.t2b.xlg.x2d, z2.tlb.t2b.xlg.x2e, z2.tlb.t2b.xlg.x2f, z2.tlb.t2b.xlg.x2g, z2.tlb.t2b.xlg.x2h, z2.tlb.t2b.xlh.x2a, z2.tlb.t2b.xlh.x2b, z2.tlb.t2b.xlh.x2c, z2.tlb.t2b.xlh.x2d, z2.tlb.t2b.xlh.x2e, z2.t1b.t2b.xlh.x2f, z2.tlb.t2b.xlh.x2g, z2.tlb.t2b.xlh.x2h, z2.tlb.t2c.xla.x2a, z2.tlb.t2c.xla.x2b, z2.tlb.t2c.xla.x2c, z2.tlb.t2c.xla.x2d, z2.tlb.t2c.xla.x2e, z2.tlb.t2c.xla.x2f, z2.tlb.t2c.xla.x2g, z2.tlb.t2c.xla.x2h, z2.tlb.t2c.xlb.x2a, z2.tlb.t2c.xlb.x2b, z2.tlb.t2c.xlb.x2c, z2.tlb.t2c.xlb.x2d, z2.tlb.t2c.xlb.x2e, z2.tlb.t2c.xlb.x2f, z2.tlb.t2c.xlb.x2g, z2.tlb.t2c.xlb.x2h, z2.tlb.t2c.xlc.x2a, z2.tlb.t2c.xlc.x2b, z2.tlb.t2c.xlc.x2c, z2.tlb.t2c.xlc.x2d, z2.tlb.t2c.xlc.x2e, z2.tlb.t2c.x1c.x2f, z2.tlb.t2c.xlc.x2g, z2.tlb.t2c.xlc.x2h, z2.tlb.t2c.xld.x2a, z2.tlb.t2c.xld.x2b, z2.tlb.t2c.xld.x2c, z2.tlb.t2c.xld.x2d, z2.tlb.t2c.xld.x2e, z2.tlb.t2c.xld.x2f, z2.t1b.t2c.x1d.x2g, z2.tlb.t2c.xld.x2h, z2.tlb.t2c.xle.x2a, z2.t1b.t2c.x1e.x2b, z2.tlb.t2c.xle.x2c, z2.tlb.t2c.xle.x2d, z2.tlb.t2c.xle.x2e, z2.tlb.t2c.xle.x2f, z2.t1b.t2c.x1e.x2g, z2.tlb.t2c.xle.x2h, z2.tlb.t2c.xlf.x2a, z2.tlb.t2c.xlf.x2b, z2.tlb.t2c.xlf.x2c, z2.tlb.t2c.xlf.x2d, z2.tlb.t2c.xlf.x2e, z2.tlb.t2c.xlf.x2f, z2.tlb.t2c.xlf.x2g, z2.tlb.t2c.xlf.x2h, z2.tlb.t2c.xlg.x2a, z2.tlb.t2c.xlg.x2b, z2.tlb.t2c.xlg.x2c, z2.tlb.t2c.xlg.x2d, z2.tlb.t2c.xlg.x2e, z2.tlb.t2c.xlg.x2f, z2.tlb.t2c.xlg.x2g, z2.tlb.t2c.xlg.x2h, z2.tlb.t2c.xlh.x2a, z2.tlb.t2c.xlh.x2b, z2.tlb.t2c.xlh.x2c, z2.tlb.t2c.xlh.x2d, z2.t1b.t2c.xlh.x2e, z2.tlb.t2c.xlh.x2f, z2.t1b.t2c.xlh.x2g, z2.tlb.t2c.xlh.x2h, z2.tlb.t2d.x1a.x2a, z2.tlb.t2d.xla.x2b, z2.tlb.t2d.xla.x2c, z2.tlb.t2d.xla.x2d, z2.tlb.t2d.xla.x2e, z2.tlb.t2d.xla.x2f, z2.tlb.t2d.xla.x2g, z2.tlb.t2d.xla.x2h, z2.tlb.t2d.xlb.x2a, z2.tlb.t2d.x1b.x2b, z2.tlb.t2d.xlb.x2c, z2.tlb.t2d.xlb.x2d, z2.tlb.t2d.xlb.x2e, z2.tlb.t2d.xlb.x2f, z2.tlb.t2d.xlb.x2g, z2.tlb.t2d.xlb.x2h, z2.tlb.t2d.xlc.x2a, z2.tlb.t2d.xlc.x2b, z2.tlb.t2d.x1c.x2c, z2.tlb.t2d.xlc.x2d, z2.tlb.t2d.x1c.x2e, z2.tlb.t2d.xlc.x2f, z2.tlb.t2d.xlc.x2g, z2.tlb.t2d.xlc.x2h, z2.tlb.t2d.xld.x2a, z2.tlb.t2d.x1d.x2b, z2.tlb.t2d.xld.x2c, z2.tlb.t2d.xld.x2d, z2.tlb.t2d.xld.x2e, z2.tlb.t2d.xld.x2f, z2.tlb.t2d.xld.x2g, z2.tlb.t2d.xld.x2h, z2.tlb.t2d.xle.x2a, z2.tlb.t2d.xle.x2b, z2.tlb.t2d.xle.x2c, z2.tlb.t2d.xle.x2d,.
z2.tlb.t2d.xle.x2e, z2.tlb.t2d.xle.x2f, z2.tlb.t2d.xle.x2g, z2.tlb.t2d.xle.x2h, z2.tlb.t2d.xlf.x2a, z2.tlb.t2d.xlf.x2b, z2.tlb.t2d.xlf.x2c, z2.tlb.t2d.xlf.x2d, z2.tlb.t2d.xlf.x2e, z2.tlb.t2d.x1f.x2f, z2.tlb.t2d.xlf.x2g, z2.tlb.t2d.xlf.x2h, z2.tlb.t2d.xlg.x2a, z2.tlb.t2d.xlg.x2b, z2.tlb.t2d.xlg.x2c, z2.tlb.t2d.xlg.x2d, z2.tlb.t2d.xlg.x2e, z2.t1b.t2d.x1g.x2f, z2.tlb.t2d.x1g.x2g, z2.tlb.t2d.xlg.x2h, z2.tlb.t2d.xlh.x2a, z2.tlb.t2d.xlh.x2b, z2.tlb.t2d.xlh.x2c, z2.tlb.t2d.xlh.x2d, z2.tlb.t2d.xlh.x2e, z2.tlb.t2d.xlh.x2f, z2.tlb.t2d.xlh.x2g, z2.tlb.t2d.xlh.x2h, z2.tlb.t2e.xla.x2a, z2.tlb.t2e.xla.x2b, z2.tlb.t2e.xla.x2c, z2.tlb.t2e.xla.x2d, z2.tlb.t2e.xla.x2e, z2.tlb.t2e.xla.x2f, z2.tlb.t2e.xla.x2g, z2.tlb.t2e.xla.x2h, z2.tlb.t2e.xlb.x2a, z2.tlb.t2e.xlb.x2b, z2.tlb.t2e.xlb.x2c, z2.tlb.t2e.x1b.x2d, z2.tlb.t2e.xlb.x2e, z2.tlb.t2e.xlb.x2f, z2.tlb.t2e.xlb.x2g, z2.tlb.t2e.xlb.x2h, z2.tlb.t2e.xlc.x2a, z2.t1b.t2e.xlc.x2b, z2.tlb.t2e.xlc.x2c, z2.tlb.t2e.xlc,.x2d, z2.tlb.t2e.xlc.x2e, z2.tlb.t2e.xlc.x2f, z2.tlb.t2e.xlc.x2g, z2.tlb.t2e.xlc.x2h, z2.tlb.t2e.xld.x2a, z2.tlb.t2e.xld.x2b, z2.tlb.t2e.xld.x2c, z2.tlb.t2e.xld.x2d, z2.tlb.t2e.xld.x2e, z2.tlb.t2e.xld.x2f, z2.t1b.t2e.xld.x2g, z2.tlb.t2e.xld.x2h, z2.tlb.t2e.xle.x2a, z2.tlb.t2e.xle.x2b, z2.tlb.t2e.xle.x2c, z2.tlb.t2e.xle.x2d, z2.tlb.t2e.xle.x2e, z2.tlb.t2e.xle.x2f, z2.tlb.t2e.xle.x2g, z2.t1b.t2e.xle.x2h, z2.tlb.t2e.xlf.x2a, z2.tlb.t2e.xlf.x2b, z2.tlb.t2e.xlf.x2c, z2.tlb.t2e.xlf.x2d, z2.tlb.t2e.xlf.x2e, z2.tlb.t2e.xlf.x2f, z2.tlb.t2e.xlf.x2g, z2.t1b.t2e.xlf.x2h, z2.t1b.t2e.xlg.x2a, z2.tlb.t2e.xlg.x2b, z2.tlb.t2e.xlg.x2c, z2.tlb.t2e.xlg.x2d, z2.tlb.t2e.xlg.x2e, z2.t1b.t2e.x1g.x2f, z2.tlb.t2e.xlg.x2g, z2.tlb.t2e.xlg.x2h, z2.tlb.t2e.xlh.x2a, z2.tlb.t2e.xlh.x2b, z2.tlb.t2e.xlh.x2c, z2.tlb.t2e.xlh.x2d, z2.tlb.t2e.xlh.x2e, z2.tlb.t2e.xlh.x2f, z2.tlb.t2e.xlh.x2g, z2.tlb.t2e.xlh.x2h, z2.tlc.t2a.xla.x2a, z2.tlc.t2a.xla.x2b, z2.tlc.t2a.xla.x2c, z2.tlc.t2a.xla.x2d, z2.tlc.t2a.xla.x2e, z2.tlc.t2a.xla.x2f, z2.tlc.t2a.xla.x2g, z2.tlc.t2a.xla.x2h, z2.tlc.t2a.xlb.x2a, z2.tlc.t2a.xlb.x2b, z2.tlc.t2a.xlb.x2c, z2.tlc.t2a.xlb.x2d, z2.tlc.t2a.xlb.x2e, z2.tlc.t2a.xlb.x2f, z2.tlc.t2a.xlb.x2g, z2.tlc.t2a.x1b.x2h, z2.tlc.t2a.xlc.x2a, z2.tlc.t2a.xlc.x2b, z2.tlc.t2a.xlc.x2c, z2.tlc.t2a.xlc.x2d, z2.tlc.t2a.xlc.x2e, z2.tlc.t2a.xlc.x2f, z2.tlc.t2a.xlc.x2g, z2.tlc.t2a.xlc.x2h, z2.tlc.t2a.xld.x2a, z2.tlc.t2a.xld.x2b, z2.tlc.t2a.xld.x2c, z2.tlc.t2a.xld.x2d, z2.tlc.t2a.xld.x2e, z2.tlc.t2a.x1d.x2f, z2.t1c.t2a.xld.x2g, z2.tlc.t2a.xld.x2h, z2.tlc.t2a.xle.x2a, z2.tlc.t2a.xle.x2b, z2.tlc.t2a.xle.x2c, z2.tlc.t2a.xle.x2d, z2.tlc.t2a.xle.x2e, z2.tlc.t2a.xle.x2f, z2.tlc.t2a.xle.x2g, z2.tlc.t2a.x1e.x2h, z2.tlc.t2a.xlf.x2a, z2.tlc.t2a.xlf.x2b, z2.tlc.t2a.xlf.x2c, z2.tlc.t2a.xlf.x2d, z2.tlc.t2a.xlf.x2e, z2.tlc.t2a.xlf.x2f, z2.tlc.t2a.xlf.x2g, z2.tlc.t2a.xlf.x2h, z2.tlc.t2a.xlg.x2a, z2.tlc.t2a.xlg.x2b, z2.tlc.t2a.xlg.x2c, z2.tlc.t2a.xlg.x2d, z2.t1c.t2a.xlg.x2e, z2.tlc.t2a.xlg.x2f, z2.t1c.t2a.xlg.x2g, z2.t1c.t2a.xlg.x2h, z2.tlc.t2a.xlh.x2a, z2.tlc.t2a.xlh.x2b, z2.tlc.t2a.xlh.x2c, z2.tlc.t2a.xlh.x2d, z2.tlc.t2a.xlh.x2e, z2.tlc.t2a.xlh.x2f, z2.tlc.t2a.xlh.x2g, z2.tlc.t2a.xlh.x2h, z2.tlc.t2b.xla.x2a, z2.tlc.t2b.xla.x2b, z2.tlc.t2b.xla.x2c, z2.tlc.t2b.xla.x2d, z2.tlc.t2b.xla.x2e, z2.tlc.t2b.xla.x2f, z2.tlc.t2b.xla.x2g, z2.tlc.t2b.x1a.x2h, z2.tlc.t2b.xlb.x2a, z2.tlc.t2b.xlb.x2b, z2.tlc.t2b.xlb.x2c, z2.tlc.t2b.xlb.x2d, z2.tlc.t2b.xlb.x2e, z2.t1c.t2b.x1b.x2f, z2.tlc.t2b.xlb.x2g, z2.tlc.t2b.xlb.x2h, z2.tlc.t2b.xlc.x2a, z2.tlc.t2b.xlc.x2b, z2.tlc.t2b.xlc.x2c, z2.tlc.t2b.xlc.x2d, z2.tlc.t2b.xlc.x2e, z2.t1c.t2b.xlc.x2f, z2.tlc.t2b.xlc.x2g, z2.tlc.t2b.xlc.x2h, z2.tlc.t2b.xld.x2a, z2.t1c_t2b.xld.x2b, z2.tlc.t2b.xld.x2c, z2.tlc.t2b.x1d.x2d, z2.tlc.t2b.xld.x2e, z2.tlc.t2b.xld.x2f, z2.tlc.t2b.xld.x2g, z2.tlc.t2b.xld.x2h, z2.tlc.t2b.xle.x2a, z2.tlc.t2b.xle.x2b, z2.tlc.t2b.xle.x2c, z2.tlc.t2b.xle.x2d, z2.tlc.t2b.xle.x2e, z2.tlc.t2b.xle.x2f, z2.tlc.t2b.xle.x2g, z2.tlc.t2b.xle.x2h, z2.tlc.t2b.xlf.x2a, z2.tlc.t2b.xlf.x2b, z2.tlc.t2b.xlf.x2c, z2.tlc.t2b.xlf.x2d, z2.tlc.t2b.xlf.x2e, z2.tlc.t2b.xlf.x2f, z2.tlc.t2b.xlf.x2g, z2.tlc.t2b.xlf.x2h, z2.tlc.t2b.xlg.x2a, z2.tlc.t2b.x1g.x2b, z2.tlc.t2b.xlg.x2c, z2.tlc.t2b.xlg.x2d, z2.tlc.t2b.xlg.x2e, z2.tlc.t2b.xlg.x2f, z2.tlc.t2b.xlg.x2g, z2.tlc.t2b.xlg.x2h, z2.tlc.t2b.x1h.x2a, z2.tlc.t2b.xlh.x2b, z2.tlc.t2b.xlh.x2c, z2.tlc.t2b.xlh.x2d, z2.tlc.t2b.xlh.x2e, z2.tlc.t2b.xlh.x2f, z2.tlc.t2b.xlh.x2g, z2.tlc.t2b.xlh.x2h, z2.tlc.t2c.x1a.x2a, z2.t1c.t2c.x1a.x2b, z2.tlc.t2c.xla.x2c, z2.tlc.t2c.xla.x2d, z2.tlc.t2c.xla.x2e, z2.tlc.t2c.xla.x2f, z2.tlc.t2c.xla.x2g, z2.tlc.t2c.xla.x2h, z2.tlc.t2c.xlb.x2a, z2.tlc.t2c.xlb.x2b, z2.tlc.t2c.xlb.x2c, z2.tlc.t2c.xlb.x2d, z2.tlc.t2c.xlb.x2e, z2.tlc.t2c.xlb.x2f, z2.tlc.t2c.xlb.x2g, z2.tlc.t2c.xlb.x2h, z2.tlc.t2c.x1c.x2a, z2.tlc.t2c.xlc.x2b, z2.tlc.t2c.xlc.x2c, z2.tlc.t2c.xlc.x2d, z2.tlc.t2c.xlc.x2e, z2.tlc.t2c.xlc.x2f, z2.tlc.t2c.xlc.x2g, z2.tlc.t2c.xlc.x2h, z2.tlc.t2c.xld.x2a, z2.tlc.t2c.xld.x2b, z2.tlc.t2c.xld.x2c, z2.tlc.t2c.xld.x2d, z2.tlc.t2c.xld.x2e, z2.tlc.t2c.xld.x2f, z2.tlc.t2c.xld.x2g, z2.tlc.t2c.xld.x2h, z2.tlc.t2c.xle.x2a, z2.tlc.t2c.xle.x2b, z2.tlc.t2c.xle.x2c, z2.tlc.t2c.xle.x2d, z2.tlc.t2c.xle.x2e, z2.tlc.t2c.xle.x2f, z2.tlc.t2c.xle.x2g, z2.tlc.t2c.xle.x2h, z2.t1c.t2c.xlf.x2a, z2.tlc.t2c.xlf.x2b, z2.tlc.t2c.xlf.x2c, z2.tlc.t2c.xlf.x2d, z2.tlc.t2c.xlf.x2e, z2.tlc.t2c.xlf.x2f, z2.tlc.t2c.xlf.x2g, z2.tlc.t2c.xlf.x2h, z2.tlc.t2c.xlg.x2a, z2.tlc.t2c.xlg.x2b, z2.tlc.t2c.xlg.x2c, z2.tlc.t2c.xlg.x2d, z2.tlc.t2c.xlg.x2e, z2.tlc.t2c.xlg.x2f, z2.tlc.t2c.xlg.x2g, z2.tlc.t2c.xlg.x2h, z2.tlc.t2c.xlh.x2a, z2.tlc.t2c.xlh.x2b, z2.tlc.t2c.xlh.x2c, z2.tlc.t2c.xlh.x2d, z2_t1c.t2c.xlh.x2e, z2.tlc.t2c.xlh.x2f, z2.tlc.t2c.xlh.x2g, z2.tlc.t2c.xlh.x2h, z2.tlc.t2d.xla.x2a, z2.tlc.t2d.xla.x2b, z2.tlc.t2d.xla.x2c, z2.tlc.t2d.xla.x2d, z2.tlc.t2d.xla.x2e, z2.tlc.t2d.xla.x2f, z2.tlc.t2d.xla.x2g, z2.tlc.t2d.xla.x2h, z2.tlc.t2d.xlb.x2a, z2.tlc.t2d.xlb.x2b, z2.tlc.t2d.xlb.x2c, z2.tlc.t2d.xlb.x2d, z2.tlc.t2d.xlb.x2e, z2.tlc.t2d.xlb.x2f, z2.tlc.t2d.xlb.x2g, z2.tlc.t2d.xlb.x2h, z2.tlc.t2d.xlc.x2a, z2.tlc.t2d.xlc.x2b, z2.tlc.t2d.x1c.x2c, z2.tlc.t2d.xlc.x2d, z2.tlc.t2d.xlc.x2e, z2.t1c.t2d.x1c.x2f, z2.tlc.t2d.xlc.x2g, z2.tlc.t2d.xlc.x2h, z2.tlc.t2d.xld.x2a, z2.tlc.t2d.xld.x2b, z2.tlc.t2d.xld.x2c, z2.tlc.t2d.xld.x2d, z2.tlc.t2d.xld.x2e, z2.tlc.t2d.xld.x2f, z2.tlc.t2d.xld.x2g, z2.tlc.t2d.xld.x2h, z2.tlc.t2d.xle.x2a, z2.tlc.t2d.xle.x2b, z2.tlc.t2d.xle.x2c, z2.tlc.t2d.xle.x2d, z2.tlc.t2d.xle.x2e, z2.tlc.t2d.xle.x2f, z2.tlc.t2d.xle.x2g, z2.tlc.t2d.xle.x2h, _ z2.t1c.t2d.xlf.x2a, z2.tlc.t2d.xlf.x2b, z2.tlc.t2d.xlf.x2c, z2.tlc.t2d.xlf.x2d, z2.tlc.t2d.xlf.x2e, z2.tlc.t2d.xlf.x2f, z2.tlc.t2d.xlf.x2g, z2.tlc.t2d.xlf.x2h, z2.t1c.t2d.xlg.x2a, z2.tlc.t2d.xlg.x2b, z2.tlc.t2d.xlg.x2c, z2.tlc.t2d.x1g.x2d, z2.tlc.t2d.xlg.x2e, z2.tlc.t2d.xlg.x2f, z2.tlc.t2d.xlg.x2g, z2.tlc.t2d.xlg.x2h, z2.tlc.t2d.xlh.x2a, z2.tlc.t2d.xlh.x2b, z2.tlc.t2d.xlh.x2c, z2.tlc.t2d.xlh.x2d, z2.tlc.t2d.xlh.x2e, z2.tlc.t2d.xlh.x2f, z2.tlc.t2d.x1h.x2g, z2.t1c.t2d.xlh.x2h, z2.tlc.t2e.xla.x2a, z2.tlc.t2e.xla.x2b, z2.tlc.t2e.xla.x2c, z2.tlc.t2e.xla.x2d, z2.tlc.t2e.xla.x2e, z2.tlc.t2e.xla.x2f, z2.tlc.t2e.xla.x2g, z2.tlc.t2e.xla.x2h, z2.tlc.t2e.xlb.x2a, z2.tlc.t2e.xlb.x2b, z2.tlc.t2e.xlb.x2c, z2.tlc.t2e.xlb.x2d, z2.tlc.t2e.xlb.x2e, z2.tlc.t2e.xlb.x2f, z2.tlc.t2e.xlb.x2g, z2.tlc.t2e.xlb.x2h, z2_tlc.t2e.xlc.x2a, z2.tlc.t2e.xlc.x2b, z2.tlc.t2e.xlc.x2c, z2.tlc.t2e.x1c.x2d, z2.tlc.t2e.xlc.x2e, z2.tlc.t2e.xlc.x2f, z2.tlc.t2e.xlc.x2g, z2.tlc.t2e.xlc.x2h, z2.tlc.t2e.xld.x2a, z2.tlc.t2e.xld.x2b, z2.tlc.t2e.xld.x2c, z2.tlc.t2e.xld.x2d, z2.tlc.t2e.xld.x2e, z2.tlc.t2e.xld.x2f, z2.tlc.t2e.xld.x2g, z2.tlc.t2e.xld.x2h, z2.tlc.t2e.x1e.x2a, z2.tlc.t2e.xle.x2b, z2.tlc.t2e.xle.x2c, z2.tlc.t2e.xle.x2d, z2.tlc.t2e.xle.x2e, z2.tlc.t2e.xle.x2f, z2.tlc.t2e.xle.x2g, z2.tlc.t2e.xle.x2h, z2.tlc.t2e.xlf.x2a, z2.tlc.t2e.xlf.x2b, z2.tlc.t2e.x1f.x2c, z2.tlc.t2e.xlf.x2d, z2.tlc.t2e.xlf.x2e, z2.tlc.t2e.xlf.x2f, z2.tlc.t2e.xlf.x2g, z2.tlc.t2e.xlf.x2h, z2.tlc.t2e.xlg.x2a, z2.tlc.t2e.xlg.x2b, z2.tlc.t2e.xlg.x2c, z2.tlc.t2e.xlg.x2d, z2.tlc.t2e.xlg.x2e, z2.tlc.t2e.xlg.x2f, z2.tlc.t2e.xlg.x2g, z2.tlc.t2e.xlg.x2h, z2.tlc.t2e.xlh.x2a, z2.tlc.t2e.xlh.x2b, z2.tlc.t2e.xlh.x2c, z2.tlc.t2e.xlh.x2d, z2.tlc.t2e.xlh.x2e, z2.tlc.t2e.xlh.x2f, z2.tlc.t2e.xlh.x2g, z2_tlc.t2e.x1h.x2h, z2.tld.t2a.x1a.x2a, z2.tld.t2a.xla.x2b, z2.tld.t2a.xla.x2c, z2.tld.t2a.xla.x2d, z2.tld.t2a.xla.x2e, z2.tld.t2a.xla.x2f, z2.tld.t2a.xla.x2g, z2.tld.t2a.xla.x2h, z2.tld.t2a.x1b.x2a, z2.tld.t2a.xlb.x2b, z2.tld.t2a.xlb.x2c, z2.tld.t2a.xlb.x2d, z2.tld.t2a.xlb.x2e, z2.tld.t2a.xlb.x2f, z2.tld.t2a.xlb.x2g, z2.tld.t2a.xlb.x2h, z2.tld.t2a.xlc.x2a, z2.tld.t2a.xlc.x2b, z2.tld.t2a.xlc.x2c, z2.tld.t2a.xlc.x2d, z2.tld.t2a.xlc.x2e, z2.tld.t2a.xlc.x2f, z2.tld.t2a.xlc.x2g, z2.tld.t2a.xlc.x2h, z2.tld.t2a.xld.x2a, z2.tld.t2a.xld.x2b, z2.tld.t2a.xld.x2c, z2.tld.t2a.xld.x2d, z2.tld.t2a.xld.x2e, z2.tld.t2a.xld.x2f, z2.tld.t2a.xld.x2g, z2.tld.t2a.xld.x2h, z2.t1d.t2a.xle.x2a, z2.tld.t2a.xle.x2b, z2.t1d.t2a.x1e.x2c, z2.tld.t2a.xle.x2d, z2.tld.t2a.xle.x2e, z2.tld.t2a.xle.x2f, z2.tld.t2a.xle.x2g, z2.tld.t2a.xle.x2h, z2.tld.t2a.xlf.x2a, z2.tld.t2a.xlf.x2b, z2.t1d.t2a.x1f.x2c, z2.tld.t2a.x1f.x2d, z2.tld.t2a.x1f.x2e, z2.tld.t2a.xlf.x2f, z2.tld.t2a.xlf.x2g, z2.tld.t2a.xlf.x2h, z2.tld.t2a.xlg.x2a, z2.tld.t2a.xlg.x2b, z2.tld.t2a.xlg.x2c, z2.tld.t2a.xlg.x2d, z2.tld.t2a.xlg.x2e, z2.tld.t2a.xlg.x2f, z2.tld.t2a.xlg.x2g, z2.tld.t2a.xlg.x2h, z2.tld.t2a.xlh.x2a, z2.tld.t2a.xlh.x2b, z2.tld.t2a.xlh.x2c, z2.tld.t2a.xlh.x2d, z2.tld.t2a.xlh.x2e, z2.tld.t2a.xlh.x2f, z2.tld.t2a.xlh.x2g, z2.tld.t2a.xlh.x2h, z2.tld.t2b.xla.x2a, z2.tld.t2b.xla.x2b, z2.tld.t2b.xla.x2c, z2.tld.t2b.xla.x2d, z2.tld.t2b.xla.x2e, z2.tld.t2b.xla.x2f, z2.tld.t2b.xla.x2g, z2.tld.t2b.xla.x2h, z2.tld.t2b.xlb.x2a, z2.tld.t2b.xlb.x2b, z2.tld.t2b.xlb.x2c, z2.tld.t2b.xlb.x2d, z2.tld.t2b.xlb.x2e, z2.tld.t2b.xlb.x2f, z2.tld.t2b.xlb.x2g, z2.tld.t2b.xlb.x2h, z2.tld.t2b.xlc.x2a, z2.tld.t2b.xlc.x2b, z2.tld.t2b.x1c.x2c, z2.tld.t2b.xlc.x2d, z2.tld.t2b.xlc.x2e, z2.tld.t2b.xlc.x2f, z2.tld.t2b.xlc.x2g, z2.tld.t2b.xlc..x2h, z2.tld.t2b.xld.x2a, z2.tld.t2b.xld.x2b, z2.tld.t2b.xld.x2c, z2.tld.t2b.xld.x2d, z2.tld.t2b.xld.x2e, z2.tld.t2b.xld.x2f, z2.tld.t2b.x1d.x2g, z2.tld.t2b.x1d.x2h, z2.tld.t2b.xle.x2a, z2.tld.t2b.xle.x2b, z2.tld.t2b.xle.x2c, z2.tld.t2b.xle.x2d, z2.tld.t2b.xle.x2e, z2.tld.t2b.xle.x2f, z2.tld.t2b.xle.x2g, z2.tld.t2b.xle.x2h, z2.tld.t2b.xlf.x2a, z2.tld.t2b.xlf.x2b, z2.tld.t2b.xlf.x2c, z2.t1d.t2b.xlf.x2d, z2.tld.t2b.xlf.x2e, z2.tld.t2b.xlf.x2f, z2.tld.t2b.xlf.x2g, z2.tld.t2b.xlf.x2h, z2.tld.t2b.xlg.x2a, z2.tld.t2b.xlg.x2b, z2.tld.t2b.xlg.x2c, z2.tld.t2b.xlg.x2d, z2.tld.t2b.xlg.x2e, z2.tld.t2b.xlg.x2f, z2.tld.t2b.xlg.x2g, z2.t1d.t2b.xlg.x2h, z2.tld.t2b.xlh.x2a, z2.tld.t2b.xlh.x2b, z2.tld.t2b.xlh.x2c, z2.tld.t2b.xlh.x2d, z2.tld.t2b.xlh.x2e, z2.t1d.t2b.xlh.x2f, z2.t1d.t2b.xlh.x2g, z2.tld.t2b.xlh.x2h, z2.tld.t2c.xla.x2a, z2.tld.t2c.xla.x2b, z2.tld.t2c.xla.x2c, z2.tld.t2c.xla.x2d, z2.t1d.t2c.x1a.x2e, z2.tld.t2c.xla.x2f, z2.tld.t2c.xla.x2g, z2.tld.t2c.xla.x2h, z2.tld.t2c.xlb.x2a, z2.tld.t2c.xlb.x2b, z2.tld.t2c.xlb.x2c, z2.tld.t2c.xlb.x2d, z2.tld.t2c.xlb.x2e, z2.tld.t2c.xlb.x2f, z2.tld.t2c.xlb.x2g, z2.tld.t2c.xlb.x2h, z2.tld.t2c.xlc.x2a, z2.tld.t2c.xlc.x2b, z2.tld.t2c.xlc.x2c, z2.tld.t2c.xlc.x2d, z2.tld.t2c.xlc.x2e, z2.tld.t2c.xlc.x2f, z2.tld.t2c.xlc.x2g, z2.tld.t2c.xlc.x2h, z2.tld.t2c.xld.x2a, z2.tld.t2c.xld.x2b, z2.tld.t2c.xld.x2c, z2.tld.t2c.xld.x2d, z2.tld.t2c.xld.x2e, z2.tld.t2c.xld.x2f, z2.tld.t2c.xld.x2g, z2.tld.t2c.xld.x2h, z2.t1d.t2c.xle.x2a, z2.tld.t2c.xle.x2b, z2.tld.t2c.xle.x2c, z2.tld.t2c.xle.x2d, z2.t1d.t2c.xle.x2e, z2.tld.t2c.xle.x2f, z2.tld.t2c.xle.x2g, z2.tld.t2c.xle.x2h, z2.tld.t2c.xlf.x2a, z2.tld.t2c.xlf.x2b, z2.tld.t2c.xlf.x2c, z2.tld.t2c.xlf.x2d, z2.tld.t2c.xlf.x2e, z2.tld.t2c.xlf.x2f, z2.t1d.t2c.xlf.x2g, z2.tld.t2c.xlf.x2h, z2.tld.t2c.xlg.x2a, z2.tld.t2c.xlg.x2b, z2.tld.t2c.xlg.x2c, z2.tld.t2c.xlg.x2d, z2.tld.t2c.xlg.x2e, z2.tld.t2c.xlg.x2f, z2.tld.t2c.xlg.x2g, z2.tld.t2c.xlg.x2h, z2.tld.t2c.xlh.x2a, z2.tld.t2c.xlh.x2b, z2.tld.t2c.xlh.x2c, z2.tld.t2c.xlh.x2d, z2.tld.t2c.xlh.x2e, z2.tld.t2c.xlh.x2f, z2.tld.t2c.xlh.x2g, z2.t1d.t2c.xlh.x2h, z2.tld.t2d.xla.x2a, z2.tld.t2d.xla.x2b, z2.tld.t2d.xla.x2c, z2.tld.t2d.xla.x2d, z2.t1d.t2d.xla.x2e, z2.tld.t2d.xla.x2f, z2.tld.t2d.xla.x2g, z2.tld.t2d.xla.x2h, z2.tld.t2d.xlb.x2a, z2.tld.t2d.xlb.x2b, z2.tld.t2d.xlb.x2c, z2.tld.t2d.xlb.x2d, z2.tld.t2d.xlb.x2e, z2.t1d.t2d.xlb:x2f, z2.tld.t2d.xlb.x2g, z2.tld.t2d.xlb.x2h, z2.tld.t2d.xlc.x2a, z2.tld.t2d.xlc.x2b, z2.tld.t2d.xlc.x2c, z2.tld.t2d.xlc.x2d, z2.tld.t2d.xlc.x2e, z2.tld.t2d.xlc.x2f, z2.tld.t2d.xlc.x2g, z2.tld.t2d.xlc.x2h, z2.tld.t2d.xld.x2a, z2.tld.t2d.xld.x2b, z2.tld.t2d.xld.x2c, z2.tld.t2d.xld.x2d, z2.tld.t2d.xld.x2e, z2.tld.t2d.xld.x2f, z2.tld.t2d.xld.x2g, z2.tld.t2d.xld.x2h, z2.tld.t2d.xle.x2a, z2.tld.t2d.xle.x2b, z2.tld.t2d.xle.x2c, z2.tld.t2d.xle.x2d, z2.tld.t2d.xle.x2e, z2.t1d.t2d.x1e.x2f, z2.tld.t2d.xle.x2g, z2.tld.t2d.xle.x2h, z2.tld.t2d.xlf.x2a, z2.tld.t2d.xlf.x2b, z2.tld.t2d.xlf.x2c, z2.tld.t2d.xlf.x2d, z2.tld.t2d.xlf.x2e, z2.tld.t2d.xlf.x2f, z2.tld.t2d.xlf.x2g, z2.tld.t2d.xlf.ic2h, z2.tld.t2d.xlg.x2a, z2_tld.t2d.x1g.x2b, z2.tld.t2d.xlg.x2c, z2.tld.t2d.xlg.x2d, z2.tld.t2d.xlg.x2e, z2.tld.t2d.xlg.x2f, z2.tld.t2d.xlg.x2g, z2.tld.t2d.xlg.x2h, z2.tld.t2d.xlh.x2a, z2.t1d.t2d.x1h.x2b, z2.tld.t2d.xlh.x2c, z2.tld.t2d.xlh.x2d, z2.tld.t2d.xlh.x2e, z2.tld.t2d.xlh.x2f, z2.tld.t2d.xlh.x2g, z2.tld.t2d.xlh.x2h, z2.tld.t2e.xla.x2a, z2.tld.t2e.xla.x2b, z2.tld.t2e.xla.x2c, z2.tld.t2e.xla.x2d, z2.tld.t2e.xla.x2e, z2.tld.t2e.xla.x2f, z2.tld.t2e.x1a.x2g, z2.tld.t2e.xla.x2h, z2.t1d.t2e.xlb.x2a, z2.tld.t2e.xlb.x2b, z2.tld.t2e.xlb.x2c, z2.tld.t2e.xlb.x2d, z2.tld.t2e.xlb.x2e, z2.tld.t2e.xlb.x2f, z2.tld.t2e.xlb.x2g, z2.tld.t2e.xlb.x2h, z2.tld.t2e.xlc.x2a, z2.tld.t2e.xlc.x2b, z2.tld.t2e.xlc.x2c, z2.tld.t2e.xlc.x2d, z2.tld.t2e.xlc.x2e, z2.tld.t2e.xlc.x2f, z2.tld.t2e.xlc.x2g, z2.tld.t2e.xlc.x2h, z2.tld.t2e.xld.x2a, z2.tld.t2e.xld.x2b, z2.tld.t2e.xld.x2c, z2.tld.t2e.xld.x2d, z2.tld.t2e.xld.x2e, z2_tld.t2e.x1d.x2f, z2.t1d.t2e.x1d.x2g, z2.tld.t2e.xld.x2h, z2.tld.t2e.xle.x2a, z2.tld.t2e.xle.x2b, z2.tld_t2e.x1e.x2c, z2.tld.t2e.xle.x2d, z2.tld.t2e.xle.x2e, z2.tld.t2e.x1e.x2f, z2.tld.t2e.xle.x2g, z2.tld.t2e.xle.x2h, z2.tld.t2e.xlf.x2a, z2.tld.t2e.xlf.x2b, z2.tld.t2e.xlf.x2c, z2.tld.t2e.xlf.x2d, z2.tld.t2e.xlf.x2e, z2.tld.t2e.xlf.x2f, z2.tld.t2e.xlf.x2g, z2.tld.t2e.xlf.x2h, z2.tld.t2e.xlg.x2a, z2.t1d_t2e.xlg.x2b, z2.tld.t2e.xlg.x2c, z2.tld.t2e.xlg.x2d, z2.tld.t2e.xlg.x2e, z2.tld.t2e.xlg.x2f, z2.t1d.t2e.x1g.x2g, z2.tld.t2e.xlg.x2h, z2.tld.t2e.xlh.x2a, z2.tld.t2e.xlh.x2b, z2.tld.t2e.xlh.x2c, z2.tld.t2e.xlh.x2d, z2.tld.t2e.xlh.x2e, z2.tld.t2e.xlh.x2f, z2.tld.t2e.xlh.x2g, z2.tld.t2e.xlh.x2h, z2.tle.t2a.xla.x2a, z2.tle.t2a.xla.x2b, z2.tle.t2a.xla.x2c, z2.tle.t2a.xla.x2d, z2.tle.t2a.xla.x2e, z2.tle.t2a.xla.x2f, z2.tle.t2a.xla.x2g, z2.tle.t2a.xla.x2h, z2.tle.t2a.xlb.x2a, z2.tle.t2a.xlb.x2b, z2.tle.t2a.xlb.x2c, z2.t1e.t2a.xlb_x2d, z2.t1e.t2a.xlb.x2e, z2.tle.t2a.xlb.x2f, z2.tle.t2a.xlb.x2g, z2.tle.t2a.xlb.x2h, z2.tle.t2a.xlc.x2a, z2.tle.t2a.xlc.x2b, z2.tle.t2a.x1c.x2c, z2.tle.t2a.xlc.x2d, z2.tle.t2a.xlc.x2e, z2.tle.t2a.xlc.x2f, z2.tle.t2a.xlc.x2g, z2.tle.t2a.xlc.x2h, z2.tle.t2a.xld.x2a, z2.tle.t2a.xld.x2b, z2.tle.t2a.xld.x2c, z2.tle.t2a.xld.x2d, z2.tle.t2a.xld.x2e, z2.tle.t2a.xld.x2f, z2.tle.t2a.xld.x2g, z2.tle.t2a.xld.x2h, z2.tle.t2a.xle.x2a, z2.tle.t2a.xle.x2b, z2.tle.t2a.xle.x2c, z2.tle.t2a.xle.x2d, z2.tle.t2a.xle.x2e, z2.tle.t2a.xle.x2f, z2.tle.t2a.xle.x2g, z2.tle.t2a.xle.x2h, z2.tle.t2a.xlf.x2a, z2.tle.t2a.x1f.x2b, z2.tle.t2a.x1f.x2c,-z2.tle.t2a.xlf.x2d, z2.t1e.t2a.x1f.x2e,-z2.tle.t2a.xlf.x2f, z2.t1e_t2a.xlf.x2g, z2.tle.t2a.xlf.x2h, z2.t1e.t2a.x1g.x2a, z2.tle.t2a.xlg.x2b, z2.tle.t2a.xlg.x2c, z2.tle.t2a.xlg.x2d, z2.tle.t2a.xlg.x2e, z2.tle.t2a.xlg.x2f, z2.tle.t2a.x1g.x2g, z2.tle.t2a.xlg.x2h, z2.tle.t2a.xlh.x2a, z2.tle.t2a.xlh.x2b, z2.tle.t2a.xlh.x2c, z2.tle.t2a.xlh.x2d, z2.tle.t2a.xlh.x2e, z2.tle.t2a.xlh.x2f, z2.tle.t2a.xlh.x2g, z2.tle.t2a.xlh.x2h, z2.tle.t2b.xla.x2a, z2.tle.t2b.xla.x2b, z2.tle.t2b.xla.x2c, z2.tle.t2b.xla.x2d, z2.tle.t2b.xla.x2e, z2.tle.t2b.xla.x2f, z2.tle.t2b.xla.x2g, z2.tle.t2b.xla.x2h, z2.tle.t2b.xlb.x2a, z2.tle.t2b.xlb.x2b, z2.tle.t2b.xlb.x2c, z2.tle.t2b.xlb.x2d, z2.tle.t2b.xlb.x2e, z2.tle.t2b.xlb.x2f, z2.tle.t2b.xlb.x2g, z2.t1e.t2b.xlb.x2h, z2.tle.t2b.xlc.x2a, z2.tle.t2b.xlc.x2b, z2.tle.t2b.xlc.x2c, z2.tle.t2b.xlc.x2d, z2.tle.t2b.xlc.x2e, z2.tle.t2b.xlc.x2f, z2.tle.t2b.xlc.x2g, z2.tle.t2b.xlc.x2h, z2.tle.t2b.xld.x2a, z2.tle.t2b.xld.x2b, z2.tle.t2b.xld.x2c, z2.tle.t2b.xld.x2d, z2.tle.t2b.xld.x2e, z2.tle.t2b.xld.x2f, z2.tle.t2b.xld.x2g, z2.tle.t2b.xld.x2h, z2.tle.t2b.xle.x2a, z2.t1e.t2b.x1e.x2b, z2.tle.t2b.xle.x2c, z2.tle.t2b.xle.x2d, z2.tle.t2b.x1e.x2e, z2.tle.t2b.xle.x2f, z2.tle.t2b.xle.x2g, z2.tle.t2b.xle.x2h, z2.tle.t2b.xlf.x2a, z2.tle.t2b.xlf.x2b, z2.tle.t2b.xlf.x2c, z2.tle.t2b.xlf.x2d, z2.tle.t2b.xlf.x2e, z2.tle.t2b.xlf.x2f, z2.tle.t2b.xlf.x2g, z2.tle.t2b.xlf.x2h, z2.tle.t2b.xlg.x2a, z2.tle.t2b.xlg.x2b, z2.tle.t2b.xlg.x2c, z2.tle.t2b.xlg.x2d, z2.tle.t2b.xlg.x2e, z2.tle.t2b.xlg.x2f, z2.tle.t2b.x1g.x2g, z2.tle.t2b.xlg.x2h, z2.tle.t2b.xlh.x2a, z2.tle.t2b.xlh.x2b, z2.tle.t2b.xlh.x2c, z2.tle.t2b.xlh.x2d, z2.tle.t2b.xlh.x2e, z2.tle.t2b.xlh.x2f, z2.tle.t2b.xlh.x2g, z2.tle.t2b.xlh.x2h, z2.tle.t2c.xla.x2a, z2.tle.t2c.xla.x2b, z2.tle.t2c.xla.x2c, z2.tle.t2c.xla.x2d, z2.tle.t2c.xla.x2e, z2.tle.t2c.xla.x2f, z2.tle.t2c.x1a.x2g, z2.tle.t2c.xla.x2h, z2.tle.t2c.xlb.x2a, z2.tle.t2c.xlb.x2b, z2.tle.t2c.xlb.x2c, z2.tle.t2c.xlb.x2d, z2.tle.t2c.xlb.x2e, z2.tle.t2c.xlb.x2f, z2.tle.t2c.xlb.x2g, z2.tle.t2c.xlb.x2h, z2.tle.t2c.xlc.x2a, z2.t1e.t2c.xlc.x2b, z2.tle.t2c.xlc.x2c, z2.tle.t2c.xlc.x2d, z2.tle.t2c.xlc.x2e, z2.tle.t2c.xlc.x2f, z2.tle.t2c.xlc.x2g, z2.tle.t2c.xlc.x2h, z2.tle.t2c.xld.x2a, z2.tle.t2c.xld.x2b, z2.tle.t2c.xld.x2c, z2_tle.t2c.xld.x2d, z2.tle.t2c.xld.x2e, z2.tle.t2c.xld.x2f, z2.tle.t2c.xld.x2g, z2.tle.t2c.xld.x2h, z2.tle.t2c.xle.x2a, z2.tle.t2c.xle.x2b, z2.tle.t2c.xle.x2c, z2.tle.t2c.xle.x2d, z2.tle.t2c.xle.x2e, z2.tle.t2c.xle.x2f, z2.tle.t2c.xle.x2g, z2.tle.t2c.xle.x2h, z2.tle.t2c.xlf.x2a, z2.tle.t2c.xlf.x2b, z2.tle.t2c.xlf.x2c, z2.tle.t2c.x1f.x2d, z2.t1e.t2c.xlf.x2e, z2.t1e.t2c.xlf.x2f, z2.tle.t2c.xlf.x2g, z2.tle.t2c.x1f.x2h, z2.tle.t2c.xlg.x2a, z2.tle.t2c.xlg.x2b, z2.tle.t2c.xlg.x2c, z2.tle.t2c.xlg.x2d, z2.tle.t2c.xlg.x2e, z2.tle.t2c.xlg.x2f, z2.tle.t2c.x1g.x2g, z2.tle.t2c.xlg.x2h, z2.tle.t2c.xlh.x2a, z2.tle.t2c.xlh.x2b, z2.tle.t2c.xlh.x2c, z2.tle.t2c.xlh.x2d, z2.tle.t2c.xlh.x2e, z2.tle.t2c.xlh.x2f, z2.t1e.t2c.xlh.x2g, z2.tle.t2c.xlh.x2h, z2.tle.t2d.xla.x2a, z2.t1e.t2d.x1a.x2b, z2.t1e.t2d.xla.x2c, z2.tle.t2d.xla.x2d, z2.tle.t2d.x1a.x2e, z2.t1e.t2d.xla.x2f, z2.tle.t2d.xla.x2g, z2.tle.t2d.xla.x2h, z2.tle.t2d.xlb.x2a, z2.tle.t2d.xlb.x2b, z2.tle.t2d.xlb.x2c, z2.tle.t2d.xlb.x2d, z2.tle.t2d.xlb.x2e, z2.tle.t2d.xlb.x2f, z2.tle.t2d.xlb.x2g, z2.tle.t2d.xlb.x2h, z2.tle.t2d.xlc.x2a, z2.tle.t2d.xlc.x2b, z2.tle.t2d.xlc.x2c, z2.tle.t2d.xlc.x2d, z2.tle.t2d.xlc.x2e, z2.tle.t2d.x1c.x2f, z2.tle.t2d.x1c.x2g, z2.tle.t2d.xlc.x2h, z2.tle.t2d.xld.x2a, z2.tle.t2d.xld.x2b, z2.tle.t2d.x1d.x2c, z2.tle.t2d.xld.x2d, z2.tle.t2d.x1d.x2e, z2.tle.t2d.xld.x2f, z2.tle.t2d.xld.x2g, z2.tle.t2d.xld.x2h, z2.tle.t2d.xle.x2a, z2.tle.t2d.xle.x2b, z2.tle.t2d.xle.x2c, z2.tle.t2d.xle.x2d, z2.tle.t2d.xle.x2e, z2.tle.t2d.xle.x2f, z2.tle.t2d.xle.x2g, z2.tle.t2d.xle.x2h, z2.tle.t2d.xlf.x2a, z2.tle.t2d.xlf.x2b, z2.tle.t2d.xlf.x2c, z2.tle.t2d.xlf.x2d, z2.tle.t2d.xlf.x2e, z2.tle.t2d.xlf.x2f, z2.tle.t2d.xlf.x2g, z2.tle.t2d.x1f.x2h, z2.tle.t2d.xlg.x2a, z2.tle.t2d.xlg.x2b, z2.tle.t2d.xlg.x2c, z2.tle.t2d.xlg.x2d, z2.tle.t2d.xlg.x2e, z2.tle.t2d.xlg.x2f, z2.tle.t2d.xlg.x2g, z2.tle.t2d.xlg.x2h, z2.tle.t2d.xlh.x2a, z2.tle.t2d.xlh.x2b, z2.tle.t2d.xlh.x2c, z2.tle.t2d.xlh.x2d, z2.tle.t2d.xlh.x2e, z2.tle.t2d.xlh.x2f, z2.tle.t2d.xlh.x2g, z2.tle.t2d.xlh.x2h, z2.tle.t2e.xla.x2a, z2.tle.t2e.xla.x2b, z2.tle.t2e.xla.x2c, z2.t1e.t2e.xla.x2d, z2.tle.t2e.xla.x2e, z2.tle.t2e.x1a.x2f, z2.tle.t2e.xla.x2g, z2.t1e.t2e.xla.x2h, z2.tle.t2e.xlb.x2a, z2.tle.t2e.xlb.x2b, z2.tle.t2e.xlb.x2c, z2.tle.t2e.xlb.x2d, z2.tle.t2e.xlb.x2e, z2.tle.t2e.xlb.x2f, z2.tle.t2e.xlb.x2g, z2.tle.t2e.xlb.x2h, z2.tle.t2e.xlc.x2a, z2.tle.t2e.xlc.x2b, z2.tle.t2e.xlc.x2c, z2.tle.t2e.xlc.x2d, z2.tle.t2e.xlc.x2e, z2.tle.t2e.xlc.x2f, z2.tle.t2e.xlc.x2g, z2.tle.t2e.xlc.x2h, z2.tle.t2e.xld.x2a, z2.tle.t2e.xld.x2b, z2.t1e.t2e.x1d.x2c, z2.tle.t2e.xld.x2d, z2.tle.t2e.xld.x2e, z2.tle.t2e.xld.x2f, z2.tle.t2e.xld.x2g, z2.tle.t2e.xld.x2h, z2.tle.t2e.xle.x2a, z2.tle.t2e.xle.x2b, z2.tle.t2e.xle.x2c, z2.tle.t2e.xle.x2d, z2.tle.t2e.xle.x2e, z2.tle.t2e.xle.x2f, z2.tle.t2e.xle.x2g, z2.tle.t2e.xle.x2h, z2.tle.t2e.xlf.x2a, z2.tle.t2e.xlf.x2b, z2.tle.t2e.xlf.x2c, z2.tle.t2e.x1f.x2d, z2.tle.t2e.xlf.x2e, z2.tle.t2e.xlf.x2f, z2.tle.t2e.xlf.x2g, z2.tle.t2e.xlf.x2h, z2.tle.t2e.xlg.x2a, z2.tle.t2e.xlg.x2b, z2.tle.t2e.xlg.x2c, z2.tle.t2e.xlg.x2d, z2.tle.t2e.xlg.x2e, z2.tle.t2e.xlg.x2f, z2.tle.t2e.xlg.x2g, z2.tle.t2e.xlg.x2h, z2.tle.t2e.xlh.x2a, z2.tle.t2e.xlh.x2b, z2.tle.t2e.xlh.x2c, z2.tle.t2e.xlh.x2d, z2.tle.t2e.xlh.x2e, z2.tle.t2e.xlh.x2f, z2.tle.t2e.xlh.x2g, z2.tle.t2e.xlh.x2h, z3.tla.t2a.x1a.x2a, z3.tla.t2a.xla.x2b, z3.tla.t2a.xla.x2c, z3.tla.t2a.xla.x2d, z3.tla.t2a.xla.x2e, z3.t1a.t2a.xla.x2f, z3.tla.t2a.xla.x2g, z3.tla.t2a.xla.x2h, z3.tla.t2a.xlb.x2a, z3.tla.t2a.xlb.x2b, z3.tla.t2a.xlb.x2c, z3.tla.t2a.xlb.x2d, z3.tla.t2a.xlb.x2e, z3.tla.t2a.xlb.x2f, z3.tla.t2a.xlb.x2g, z3.tla.t2a.xlb.x2h, z3.tla.t2a.xlc.x2a, z3.tla.t2a.xlc.x2b, z3.tla.t2a.xlc.x2c, z3.tla.t2a.xlc.x2d, z3.tla.t2a.xlc.x2e, z3.tla.t2a.xlc.x2f, z3.tla.t2a.xlc.x2g, z3.tla.t2a.xlc.x2h, z3.tla.t2a.xld.x2a, z3.tla.t2a.xld.x2b, z3.tla.t2a.xld.x2c, z3.tla.t2a.x1d.x2d, z3.t1a.t2a.x1d.x2e, z3:t1a.t2a.xld.x2f, z3.tla.t2a.xld.x2g, z3.tla.t2a.xld.x2h, z3.tla.t2a.xle.x2a, z3.tla.t2a.xle.x2b, z3.tla.t2a.xle.x2c, z3.tla.t2a.xle.x2d, z3.tla.t2a.xle.x2e, z3.tla.t2a.xle.x2f, z3.tla.t2a.xle.x2g, z3.tla.t2a.xle.x2h, z3.tla.t2a.xlf.x2a, z3.tla.t2a.xlf.x2b, z3.tla.t2a.xlf.x2c, z3.tla.t2a.xlf.x2d, z3.tla.t2a.xlf.x2e, z3.tla.t2a.xlf.x2f, z3.tla.t2a.xlf.x2g, z3.tla.t2a.xlf.x2h, z3.tla.t2a.xlg.x2a, z3.tla.t2a.xlg.x2b, z3.tla.t2a.xlg.x2c, z3.tla.t2a.xlg.x2d, z3.tla.t2a.xlg.x2e, z3.tla.t2a.xlg.x2f, z3.tla.t2a.xlg.x2g, z3.tla.t2a.xlg.x2h, z3.tla.t2a.xlh.x2a, z3.tla.t2a.xlh.x2b, z3.tla.t2a.xlh.x2c, z3.tla.t2a.xlh.x2d, z3.tla.t2a.xlh.x2e, z3.tla.t2a.xlh.x2f, z3.t1a.t2a.x1h.x2g, z3.tla.t2a.xlh.x2h, z3.tla.t2b:xla.x2a, z3.tla.t2b.xla.x2b, z3.tla.t2b.xla.x2c, z3.tla.t2b.xla.x2d, z3.tla.t2b.xla.x2e, z3.tla.t2b.xla.x2f, z3.tla.t2b.xla.x2g, z3.tla.t2b.xla.x2h, z3.tla.t2b.xlb.x2a, z3.tla.t2b.xlb.x2b, z3.tla.t2b.xlb.x2c, z3.tla.t2b.xlb.x2d, z3.tla.t2b.xlb.x2e, z3.tla.t2b.xlb.x2f, z3.tla.t2b.xlb.x2g, z3.tla.t2b.xlb.x2h, z3.tla.t2b.xlc_x2a, z3.tla.t2b.xlc.x2b, z3.tla.t2b.xlc.x2c, z3.t1a.t2b.x1c.x2d, z3.tla.t2b:xlc.x2e, z3.t1a.t2b.x1c.x2f, z3.tla.t2b.xlc.x2g, z3.tla.t2b.xlc.x2h, z3.t1a.t2b.x1d.x2a, z3.tla.t2b.xld.x2b, z3.tla.t2b.xld.x2c, z3.tla.t2b.xld.x2d, z3.tla.t2b.x1d.x2e, z3.tla.t2b.xld.x2f, z3.tla.t2b.xld.x2g, z3.tla.t2b.xld.x2h, z3.tla.t2b.xle.x2a, z3.tla.t2b.xle.x2b, z3.tla:t2b.xle.x2c, z3.tla.t2b.xle.x2d, z3.tla.t2b.xle.x2e, z3.tla.t2b.xle.x2f, z3.tla.t2b.xle.x2g, z3.tla.t2b.xle.x2h, .z3.tla.t2b.xlf.x2a, z3.tla.t2b.xlf.x2b, z3.tla.t2b.xlf.x2c, z3.tla.t2b.xlf.x2d, z3.tla.t2b.xlf.x2e, z3.tla.t2b.xlf.x2f, z3.tla.t2b.x1f.x2g, z3.tla.t2b.xlf.x2h, z3.tla.t2b.xlg.x2a, z3.tla.t2b.xlg.x2b, z3.tla.t2b.xlg.x2c, z3.tla.t2b.x1g.x2d, z3.tla.t2b.xlg.x2e, z3.tla.t2b.xlg.x2f, z3.tla.t2b.xlg.x2g, z3.tla.t2b.x1g.x2h;
z3.tla.t2b.xlh.x2a, z3.tla.t2b.xlh.x2b, z3.tla.t2b.xlh.x2c, z3.tla.t2b.xlh.x2d, z3.tla.t2b.xlh.x2e, z3.tla.t2b.xlh.x2f, z3.tla.t2b.xlh.x2g, z3.tla.t2b.xlh.x2h, z3.tla.t2c.xla.x2a, z3.tla.t2c.xla.x2b, z3.tla.t2c.xla.x2c, z3.tla.t2c.xla.x2d, z3.t1a.t2c.xla.x2e, z3.tla.t2c.xla.x2f, z3.tla.t2c.xla.x2g, z3.tla.t2c.xla.x2h, z3.tla.t2c.xlb.x2a, z3.tla.t2c.xlb.x2b, z3.tla.t2c.xlb.x2c, z3.tla.t2c.xlb.x2d, z3.tla.t2c.xlb.x2e, z3.tla.t2c.xlb.x2f, z3.tla.t2c.xlb.x2g, z3.tla.t2c.xlb.x2h, z3.tla.t2c.xlc.x2a, z3.tla.t2c.xlc.x2b, z3.tla.t2c.xlc.x2c, z3.tla.t2c.xlc.x2d, z3.tla.t2c.xlc.x2e, z3.tla.t2c.xlc.x2f, z3.tla.t2c.xlc.x2g, z3.tla.t2c.xlc.x2h, z3.tla.t2c.xld.x2a, z3.tla.t2c.x1d.x2b, z3.tla.t2c.xld.x2c, z3.tla.t2c.xld.x2d, z3.tla.t2c.xld.x2e, z3.tla.t2c.xld.x2f, z3.t1a.t2c.xld_x2g, z3.tla.t2c.xld.x2h, z3.tla.t2c.xle.x2a, z3.tla.t2c.xle.x2b, z3.tla.t2c.xle.x2c, z3.tla.t2c.xle.x2d, z3.tla.t2c.xle.x2e, z3.tla.t2c.xle.x2f, z3.tla.t2c.xle.x2g, z3.tla.t2c.xle.x2h, z3.tla.t2c.xlf.x2a, z3.tla.t2c.xlf.x2b, z3.tla.t2c.x1f.x2c, z3.tla.t2c.xlf.x2d, z3.tla.t2c.xlf.x2e, z3.tla.t2c.xlf.x2f, z3.tla.f2c.xlf.x2g, z3.tla.t2c.xlf.x2h, z3.tla.t2c.xlg.x2a, z3.tla.t2c.xlg.x2b, z3.tla.t2c.xlg.x2c, z3.tla.t2c.xlg.x2d, z3.tla.t2c.xlg.x2e, z3.tla.t2c.xlg.x2f, z3.tla.t2c.xlg.x2g, z3.tla.t2c.xlg.x2h, z3.tla.t2c.xlh.x2a, z3.tla.t2c.xlh.x2b, z3.tla.t2c.xlh.x2c, z3.tla.t2c.xlh.x2d, z3.tla.t2c.xlh.x2e, z3.tla.t2c.xlh.x2f, z3.tla.t2c.xlh.x2g, z3.tla.t2c.xlh.x2h, z3.tla.t2d.xla.x2a, z3.tla.t2d.xla.x2b, z3.tla.t2d.xla.x2c, z3.tla.t2d.xla.x2d, z3.tla.t2d.xla.x2e, z3.tla.t2d.xla.x2f, z3.tla.t2d.xla.x2g, z3.tla.t2d.xla.x2h, z3.tla.t2d.xlb.x2a, z3.tla.t2d.xlb.x2b, z3.tla.t2d.xlb.x2c, z3.t1a.t2d.xlb.x2d, z3.tla.t2d.xlb.x2e, z3.tla.t2d.xlb.x2f, z3.tla.t2d.xlb.x2g, z3.tla.t2d.xlb.x2h, z3.tla.t2d.xlc.x2a, z3.tla.t2d.xlc.x2b, z3.tla.t2d.xlc.x2c, z3.tla.t2d.xlc.x2d, z3.tla.t2d.xlc.x2e, z3.tla.t2d.xlc.x2f, z3.tla.t2d.xlc.x2g, z3.tla.t2d.xlc.x2h, z3.tla.t2d.xld.x2a, z3.tla.t2d.xld.x2b, z3.tla.t2d.xld.x2c, z3.tla.t2d.xld.x2d, z3.tla.t2d.xld.x2e, z3.tla.t2d.xld.x2f, z3.t1a.t2d.xld.x2g, z3.tla.t2d.xld.x2h, z3.tla.t2d.xle.x2a, z3.tla.t2d.xle.x2b, z3.tla.t2d.xle.x2c, z3.tla.t2d.xle.x2d, z3.tla.t2d.xle.x2e, z3.tla.t2d.xle.x2f, z3.tla.t2d.xle.x2g, z3.tla.t2d.xle.x2h, z3.tla.t2d.xlf.x2a, z3.tla.t2d.xlf.x2b, z3.tla.t2d.xlf.x2c, z3.tla.t2d.xlf.x2d, z3.tla.t2d.xlf.x2e, z3.tla.t2d.xlf.x2f, z3.tla.t2d.xlf.x2g, z3.tla.t2d.xlf.x2h, z3.tla.t2d.xlg.x2a, z3.tla.t2d.xlg.x2b, z3.tla.t2d.xlg.x2c, z3.tla.t2d.xlg.x2d, z3.tla.t2d.xlg.x2e, z3.tla.t2d.xlg.x2f, z3.tla.t2d.xlg.x2g, z3.tla.t2d.xlg.x2h, z3.tla.t2d.xlh.x2a, z3.tla.t2d.xlh.x2b, z3.tla.t2d.xlh.x2c, z3.tla.t2d.xlh.x2d, z3.tla.t2d.xlh.x2e, z3.tla.t2d.xlh.x2f, z3.tla.t2d.xlh.x2g, z3.tla.t2d.xlh.x2h, z3.tla.t2e.xla.x2a, z3.tla.t2e.xla.x2b, z3.tla.t2e.xla.x2c, z3.tla.t2e.xla.x2d, z3.tla.t2e.xla.x2e, z3.tla.t2e.xla.x2f, z3.tla.t2e.xla.x2g, z3.tla.t2e.xla.x2h, z3.tla.t2e.xlb.x2a, z3.tla.t2e.xlb.x2b, z3.tla.t2e.xlb.x2c, z3.tla.t2e.xlb.x2d, z3.tla.t2e.xlb.x2e, z3.tla.t2e.xlb.x2f, z3.tla.t2e.xlb.x2g, z3.t1a.t2e.xlb.x2h, z3.tla.t2e.xlc.x2a, z3.tla.t2e.xlc.x2b, z3.tla.t2e.xlc.x2c, z3.tla.t2e.xlc.x2d, z3.tla.t2e.xlc.x2e, z3.tla.t2e.xlc.x2f, z3.tla.t2e.xlc.x2g, z3.tla.t2e.xlc.x2h, z3.tla.t2e.xld.x2a, z3.tla.t2e.xld.x2b, z3.tla.t2e.xld.x2c, z3.tla.t2e.xld.x2d, z3.tla.t2e.xld.x2e, z3.tla.t2e.xld.x2f, z3.tla.t2e.xld.x2g, z3.tla.t2e.xld.x2h, z3.tla.t2e.xle.x2a, z3.tla.t2e.xle.x2b, z3.tla.t2e.xle.x2c, z3.tla.t2e.xle.x2d, z3.tla.t2e.xle.x2e, z3.tla.t2e.xle.x2f, z3.tla.t2e.xle.x2g, z3.tla.t2e.xle.x2h, z3.tla.t2e.xlf.x2a, z3.tla.t2e.xlf.x2b, z3.tla.t2e.xlf.x2c, z3.tla.t2e.xlf.x2d, z3.tla.t2e.xlf.x2e, z3.tla.t2e.xlf.x2f, z3.tla.t2e.xlf.x2g, z3.tla.t2e.xlf.x2h, z3.tla.t2e.xlg.x2a, z3.tla.t2e.xlg.x2b, z3.tla.t2e.xlg.x2c, z3.tla.t2e.xlg.x2d, z3.tla.t2e.xlg.x2e, z3.tla.t2e.xlg.x2f, z3.tla.t2e.xlg.x2g, z3.tla.t2e.xlg.x2h, z3.t1a.t2e.xlh.x2a, z3.tla.t2e.xlh.x2b, z3.tla.t2e.xlh.x2c, z3.tla.t2e.xlh.x2d, z3.tla.t2e.xlh.x2e, z3.tla.t2e.xlh.x2f, z3.tla.t2e.xlh.x2g, z3.tla.t2e.xlh.x2h, z3.tlb.t2a.xla.x2a, z3.tlb.t2a.xla.x2b, z3.tlb.t2a.xla.x2c, z3.tlb.t2a.xla.x2d, z3.tlb.t2a.xla.x2e, z3.tlb.t2a.xla.x2f, z3.tlb.t2a.xla.x2g, z3.tlb.t2a.xla.x2h, z3.tlb.t2a.xlb.x2a, z3.tlb.t2a.x1b.x2b, z3.t1b.t2a.xlb.x2c, z3.tlb.t2a.xlb.x2d, z3.t1b.t2a.xlb.x2e, z3.tlb.t2a.x1b.x2f, z3.tlb.t2a.xlb.x2g, z3.tlb.t2a.xlb.x2h, z3.tlb.t2a.xlc.x2a, z3.tlb.t2a.xlc.x2b, z3.tlb.t2a.xlc.x2c, z3.tlb.t2a.xlc.x2d, z3.tlb.t2a.xlc.x2e, z3.tlb.t2a.xlc.x2f, z3.tlb.t2a.xlc.x2g, z3.tlb.t2a.xlc.x2h, z3.tlb.t2a.xld.x2a, z3.tlb.t2a.xld.x2b, z3.tlb.t2a.xld.x2c, z3.tlb.t2a.xld.x2d, z3.tlb.t2a.xld.x2e, z3.tlb.t2a.xld.x2f, z3.tlb.t2a.xld.x2g, z3.tlb.t2a.xld.x2h, z3.tlb.t2a.xle.x2a, z3.tlb.t2a.xle.x2b, z3.tlb.t2a.xle.x2c, z3.tlb.t2a.xle.x2d, z3.tlb.t2a.xle.x2e, z3.tlb.t2a.xle.x2f, z3.tlb.t2a.xle.x2g, z3.tlb.t2a.xle.x2h, z3.t1b.t2a.xlf.x2a, z3.tlb.t2a.xlf.x2b, z3.t1b.t2a.x1f.x2c, z3.tlb.t2a.xlf.x2d, z3.tlb.t2a.xlf.x2e, z3.tlb.t2a.xlf.x2f, z3.tlb.t2a.xlf.x2g, z3.tlb.t2a.xlf.x2h, z3.tlb.t2a.xlg.x2a, z3.tlb.t2a.xlg.x2b, z3.tlb.t2a.xlg.x2c, z3.tlb.t2a.xlg.x2d, z3.tlb.t2a.xlg.x2e, z3.tlb.t2a.xlg.x2f, z3.tlb.t2a.xlg.x2g, z3.tlb.t2a.xlg.x2h, z3.tlb.t2a.xlh.x2a, z3.tlb.t2a.xlh.x2b, z3.tlb.t2a.xlh.x2c, z3.tlb.t2a.xlh.x2d, z3.tlb.t2a.xlh.x2e, z3.tlb.t2a.xlh.x2f, z3.tlb.t2a.xlh.x2g, z3.tlb.t2a.xlh.x2h, z3.tlb.t2b.xla.x2a; z3.tlb.t2b.xla.x2b, z3.tlb.t2b.xla.x2c, z3.tlb.t2b.xla.x2d, z3.tlb.t2b.xla.x2e, z3.t1b.t2b.xla.x2f, z3.tlb.t2b.x1a.x2g, z3.tlb.t2b.xla.x2h, z3.tlb.t2b.xlb.x2a, z3.tlb.t2b.xlb.x2b, z3.tlb.t2b.xlb.x2c, z3.tlb.t2b.xlb.x2d, z3.tlb.t2b.xlb.x2e, z3.t1b.t2b.xlb.x2f, z3.tlb.t2b.xlb.x2g, z3.tlb.t2b.xlb.x2h, z3.tlb.t2b.xlc.x2a, z3.tlb.t2b.xlc.x2b, z3.tlb.t2b.xlc.x2c, z3.tlb.t2b.xlc.x2d, z3.tlb.t2b.xlc.x2e, z3.tlb.t2b.xlc.x2f, z3.tlb.t2b.xlc.x2g, z3.t1b.t2b.xlc.x2h, z3.t1b.t2b.xld.x2a, z3.tlb.t2b.xld.x2b, z3.tlb.t2b.xld.x2c, z3.tlb.t2b.xld.x2d, z3.tlb.t2b.xld.x2e, z3.tlb.t2b.xld.x2f, z3.tlb.t2b.xld.x2g, z3.tlb.t2b.xld.x2h, z3.tlb.t2b.xle.x2a, z3.tlb.t2b.xle.x2b, z3.tlb.t2b.xle.x2c, z3.tlb.t2b.xle.x2d, z3.tlb.t2b.xle.x2e, z3.tlb.t2b.xle.x2f, z3.tlb.t2b.xle.x2g, z3.tlb.t2b.xle.x2h, z3.tlb.t2b.xlf.x2a, z3.tlb.t2b.xlf.x2b, z3.t1b.t2b_x1f.x2c, z3.tlb.t2b.xlf.x2d, z3.tlb.t2b.xlf.x2e, z3.tlb.t2b.x1f.x2f, z3.tlb.t2b.xlf.x2g, z3.tlb.t2b.xlf.x2h, z3.tlb.t2b.xlg.x2a, z3.tlb.t2b.xlg.x2b, z3.tlb.t2b.xlg.x2c, z3.tlb.t2b.xlg.x2d, z3.tlb.t2b.xlg.x2e, z3.tlb.t2b.xlg.x2f, z3.tlb.t2b.xlg.x2g, z3.tlb.t2b.xlg.x2h, z3.tlb.t2b.xlh.x2a, z3.tlb.t2b.xlh.x2b, z3.tlb.t2b.xlh.x2c, z3.tlb.t2b.xlh.x2d, z3.tlb.t2b.xlh.x2e, z3.tlb.t2b.xlh.x2f, z3.tlb.t2b.xlh.x2g, z3.tlb.t2b.xlh.x2h, z3.t1b.t2c.xla.x2a, z3.t1b.t2c.xla.x2b, z3.t1b.t2c.xla.x2c, z3.tlb.t2c.xla.x2d, z3.tlb.t2c.xla.x2e, z3.t1b_t2c.x1a.x2f, z3.tlb.t2c.xla.x2g, z3.tlb.t2c.xla.x2h, z3.tlb.t2c.xlb.x2a, z3.tlb.t2c.xlb.x2b, z3.tlb.t2c.xlb.x2c, z3.tlb.t2c.xlb.x2d, z3.tlb.t2c.xlb.x2e, z3.tlb.t2c.xlb.x2f, z3.tlb.t2c.xlb.x2g, z3.tlb.t2c.xlb.x2h, z3.tlb.t2c.xlc.x2a, z3.tlb.t2c.xlc.x2b, z3.tlb.t2c.xlc.x2c, z3.tlb.t2c.xlc.x2d, z3.tlb.t2c.xlc.x2e, z3.tlb.t2c.xlc.x2f, z3.t1b.t2c.xlc.x2g, z3.tlb.t2c.xlc.x2h, z3.tlb.t2c.xld.x2a, z3.tlb.t2c.xld.x2b, z3.tlb.t2c.xld.x2c, z3.tlb.t2c.xld.x2d, z3.tlb.t2c.xld.x2e, z3.t1b.t2c.xld.x2f, z3.tlb.t2c.xld.x2g, z3.tlb.t2c.xld.x2h, z3.t1b.t2c.xle.x2a, z3.tlb.t2c.xle.x2b,-z3.tlb.t2c.xle.x2c, z3.tlb.t2c.xle.x2d, z3.tlb.t2c.xle.x2e, z3.tlb.t2c.xle.x2f, z3.tlb.t2c.xle.x2g, z3.tlb.t2c.xle.x2h, z3.tlb.t2c.xlf.x2a, z3.tlb.t2c.xlf.x2b, z3.tlb.t2c.xlf.x2c, z3.tlb.t2c.xlf.x2d, z3.tlb.t2c.xlf.x2e, z3.tlb.t2c.xlf.x2f, z3.tlb.t2c.xlf.x2g, z3.tlb.t2c.xlf.x2h, z3.tlb.t2c.xlg.x2a, z3.tlb.t2c.xlg.x2b, z3.tlb.t2c.xlg.x2c, z3.tlb.t2c.xlg.x2d, z3.tlb.t2c.xlg.x2e, z3.tlb.t2c.xlg.x2f, z3.tlb.t2c.xlg.x2g, z3.tlb.t2c.xlg.x2h, z3.tlb.t2c.xlh.x2a, z3.t1b.t2c.xlh.x2b, z3.tlb.t2c.xlh.x2c, z3.tlb.t2c.xlh.x2d, z3.tlb.t2c.xlh.x2e, z3.tlb.t2c.xlh.x2f, z3.tlb.t2c.xlh.x2g, z3.tlb.t2c.xlh.x2h, z3.tlb.t2d.x1a.x2a, z3.tlb.t2d.xla.x2b, z3.tlb.t2d.xla.x2c, z3.tlb.t2d.xla.x2d, z3.tlb.t2d.x1a.x2e, z3.tlb.t2d.xla.x2f, z3.t1b.t2d.xla.x2g, z3.tlb.t2d.xla.x2h, z3.tlb.t2d.xlb.x2a, z3.tlb.t2d.xlb.x2b, z3.tlb.t2d.xlb.x2c, z3.tlb.t2d.xlb.x2d, z3.tlb.t2d.xlb.x2e, z3.tlb.t2d.xlb.x2f, z3.tlb.t2d.xlb.x2g, z3.tlb.t2d.xlb.x2h, z3.tlb.t2d.xlc.x2a, z3.tlb.t2d.xlc.x2b, z3.tlb.t2d.xlc.x2c, z3.tlb.t2d.xlc.x2d, z3.tlb.t2d.xlc.x2e, z3.tlb.t2d.xlc.x2f, z3.tlb.t2d.xlc.x2g, z3.tlb.t2d.xlc.x2h, z3.tlb.t2d.xld.x2a, z3.tlb.t2d.xld.x2b, z3.tlb.t2d.xld.x2c, z3.tlb.t2d.xld.x2d, z3.tlb.t2d.xld.x2e, z3.tlb.t2d.xld.x2f, z3.tlb.t2d.xld.x2g, z3.tlb.t2d.xld.x2h, z3.t1b.t2d.xle.x2a, z3.t1b.t2d.xle.x2b, z3.tlb.t2d.xle.x2c, z3.tlb.t2d.xle.x2d, z3.tlb.t2d.xle.x2e, z3.tlb.t2d.xle.x2f, z3.tlb.t2d.xle.x2g, z3.tlb.t2d.xle.x2h, z3.tlb.t2d.xlf.x2a, z3.tlb.t2d.xlf.x2b, z3.tlb.t2d.xlf.x2c, z3.tlb.t2d.xlf.x2d, z3.t1b.t2d.xlf.x2e, z3.t1b.t2d.xlf.x2f, z3.tlb.t2d.xlf.x2g, z3.tlb.t2d.xlf.x2h, z3.tlb.t2d.xlg.x2a, z3.tlb.t2d.xlg.x2b, z3.tlb.t2d.xlg.x2c, z3.tlb.t2d.xlg.x2d, z3.tlb.t2d.xlg.x2e, z3.tlb.t2d.xlg.x2f, z3.tlb.t2d.xlg.x2g, z3.tlb.t2d.xlg.x2h, z3.tlb.t2d.x1h.x2a, z3.tlb.t2d.xlh.x2b, z3.tlb.t2d.xlh.x2c, z3.tlb.t2d.xlh.x2d, z3.tlb.t2d.xlh.x2e, z3.t1b.t2d.x1h.x2f, z3.tlb.t2d.xlh.x2g, z3.tlb.t2d.xlh.x2h, z3.t1b.t2e.x1a:x2a, z3.tlb.t2e.xla.x2b, z3.tlb.t2e.xla.x2c, z3.tlb.t2e.xla.x2d, z3.tlb.t2e.xla.x2e, z3.tlb.t2e.xla.x2f, z3.tlb.t2e.xla.x2g, z3.tlb.t2e.xla.x2h, z3.tlb.t2e.xlb.x2a, z3.tlb.t2e.xlb.x2b, z3.tlb.t2e.xlb.x2c, z3.tlb.t2e.xlb.x2d, z3.tlb.t2e.xlb.x2e, z3.tlb.t2e.xlb.x2f, z3.t1b.t2e.x1b.x2g, z3.t1b.t2e.xlb.x2h, z3.tlb.t2e.xlc.x2a, z3.tlb.t2e.xlc.x2b, z3.tlb.t2e.xlc.x2c, z3.t1b.t2e.xlc.x2d, z3.tlb.t2e.xlc.x2e, z3.tlb.t2e.xlc.x2f, z3.t1b.t2e.xlc.x2g, z3.tlb.t2e.xlc.x2h, z3.tlb.t2e.xld.x2a, z3.t1b.t2e.xld.x2b, z3.tlb.t2e.xld.x2c, z3.tlb.t2e.xld.x2d, z3.tlb:t2e.xld.x2e, z3.tlb.t2e.xld.x2f, z3.tlb.t2e.xld.x2g, z3.tlb.t2e.xld.x2h, z3.tlb.t2e.xle.x2a, z3.tlb.t2e.xle.x2b, z3.tlb.t2e.xle.x2c, z3.tlb.t2e.xle.x2d, z3.tlb.t2e.xle.x2e, z3.t1b.t2e.x1e.x2f, z3.tlb.t2e.xle.x2g, z3.tlb.t2e.xle.x2h, z3.tlb.t2e.xlf.x2a, z3.tlb.t2e.xlf.x2b, z3.tlb.t2e.xlf.x2c, z3.tlb.t2e.xlf.x2d, z3.tlb.t2e.xlf.x2e, z3.tlb.t2e.x1f.x2f, z3.tlb.t2e.xlf.x2g, z3.tlb.t2e.xlf.x2h, -35 z3.tlb.t2e.xlg.x2a, z3.tlb.t2e.xlg.x2b, z3.tlb.t2e.xlg.x2c, z3.tlb.t2e.xlg.x2d, z3.tlb.t2e.xlg.x2e, z3.tlb.t2e.xlg.x2f, z3.tlb.t2e.xlg.x2g, z3.tlb.t2e.xlg.x2h, z3.t1b.t2e.x1h.x2a, z3.tlb.t2e.xlh.x2b, z3.tlb.t2e.xlh.x2c, z3.tlb.t2e.xlh.x2d, z3.tlb.t2e.xlh.x2e, z3.tlb.t2e.xlh.x2f, z3.tlb.t2e.xlh.x2g, z3.tlb.t2e.xlh.x2h, z3.tlc.t2a.xla.x2a, z3.tlc.t2a.xla.x2b, z3.tlc.t2a.xla.x2c, z3.tlc.t2a.xla.x2d, z3.tlc.t2a.xla.x2e, z3.tlc.t2a.xla.x2f, z3.tlc.t2a.x1a.x2g, z3.tlc.t2a.xla.x2h, z3.tlc.t2a.xlb.x2a, z3.tlc.t2a.xlb.x2b, z3.tlc.t2a.xlb.x2c, z3.tlc.t2a.xlb.x2d, z3.tlc.t2a.xlb.x2e, z3.tlc.t2a.xlb.x2f, z3.tlc.t2a.x1b.x2g, z3.tlc.t2a.xlb.x2h, z3.tlc.t2a.xlc.x2a, z3.tlc.t2a.xlc.x2b, z3.t1c.t2a.xlc.x2c, z3.tlc.t2a.xlc.x2d, z3.tlc.t2a.xlc.x2e, z3.tlc.t2a.xlc.x2f, z3.tlc.t2a.x1c.x2g, z3.tlc.t2a.xlc.x2h, z3.tlc.t2a.xld.x2a, z3.tlc.t2a.xld.x2b, z3.tlc.t2a.xld.x2c, z3.tlc.t2a.xld.x2d, z3.tlc.t2a.xld.x2e, z3.tlc.t2a.xld.x2f, z3.tlc.t2a.xld.x2g, z3.tlc.t2a.xld.x2h, z3.tlc.t2a.xle.x2a, z3.tlc.t2a.xle.x2b, z3.tlc.t2a.xle.x2c, z3.t1c.t2a.xle.x2d, z3.tlc.t2a.xle.x2e, z3.tlc.t2a.xle.x2f, z3.tlc.t2a.xle.x2g, z3.tlc.t2a.xle.x2h, z3.tlc.t2a.xlf.x2a, z3.tlc.t2a.xlf.x2b, z3.tlc.t2a.xlf.x2c, z3.tlc.t2a.xlf.x2d, z3.tlc.t2a.xlf.x2e, z3.tlc.t2a.xlf.x2f, z3.tlc.t2a.xlf.x2g, z3.tlc.t2a.xlf.x2h, z3.tlc.t2a.xlg.x2a, z3.tlc.t2a.xlg.x2b, z3.tlc.t2a.xlg.x2c, z3.tlc.t2a.xlg.x2d, z3.tlc.t2a.xlg.x2e, z3.tlc.t2a.xlg.x2f, z3.t1c.t2a.x1g.x2g, z3.tlc.t2a.xlg.x2h, z3.tlc.t2a.xlh.x2a, z3.tlc.t2a.xlh.x2b, z3.tlc.t2a.xlh.x2c, z3.tlc.t2a.xlh.x2d, z3.tlc.t2a.xlh.x2e, z3.tlc.t2a.xlh.x2f, z3.tlc.t2a.xlh.x2g, z3.tlc.t2a.xlh.x2h, z3.tlc.t2b.xla.x2a, z3.tlc.t2b.xla.x2b, z3.tlc.t2b.xla.x2c, z3,tlc.t2b.xla.x2d, z3.tlc.t2b.xla.x2e, z3.tlc.t2b.x1a.x2f, z3_t1c.t2b.xla.x2g, z3.tlc.t2b.xla.x2h, z3.t1c.t2b.xlb.x2a, z3.tlc.t2b.xlb.x2b, z3.tlc.t2b.xlb.x2c, z3.tlc.t2b.xlb.x2d, z3.tlc.t2b.xlb.x2e, z3.tlc.t2b.xlb.x2f, z3.tlc.t2b.xlb.x2g, z3.tlc.t2b.xlb.x2h, z3.tlc.t2b.xlc.x2a, z3.tlc.t2b.xlc.x2b, z3.tlc.t2b.xlc.x2c, z3.tlc.t2b.xlc.x2d, z3.t1c.t2b.xlc.x2e, z3.tlc.t2b.xlc.x2f, z3.tlc.t2b.xlc.x2g, z3.tlc.t2b.xlc.x2h, z3.tlc.t2b.xld.x2a, z3.tlc.t2b.xld.x2b, z3.t1c.t2b_x1d.x2c, z3.tlc.t2b.xld.x2d, z3.tlc.t2b.xld.x2e, z3.tlc.t2b.xld.x2f, z3.tlc.t2b.xld.x2g, z3.tlc.t2b.xld.x2h, z3.tlc.t2b.xle.x2a, z3.tlc.t2b.xle.x2b, z3.tlc.t2b.xle.x2c, z3.tlc.t2b.xle.x2d, z3.tlc.t2b.xle.x2e, z3.tlc.t2b.xle.x2f, z3.tlc.t2b.xle.x2g, z3.tlc.t2b.xle.x2h, z3.tlc.t2b.xlf.x2a, z3.tlc.t2b.xlf.x2b, z3.tlc.t2b.xlf.x2c, z3.tlc.t2b.xlf.x2d, z3.tlc.t2b.xlf.x2e, z3.tlc.t2b.xlf.x2f, z3.tlc.t2b.xlf.x2g, z3.tlc.t2b.xlf.x2h, z3.tlc.t2b.xlg.x2a, z3.tlc.t2b.xlg.x2b, 'z3.t1c.t2b.x1g.x2c, z3.tlc.t2b.xlg.x2d, z3.tlc.t2b.xlg.x2e, z3.tlc.t2b.xlg.x2f, z3.tlc.t2b.xlg.x2g, z3.tlc.t2b.xlg.x2h, z3.tlc.t2b.xlh.x2a, z3.tlc.t2b.xlh.x2b, z3.tlc.t2b.xlh.x2c, z3.tlc.t2b.xlh.x2d, z3.tlc.t2b.xlh.x2e, z3.tlc.t2b.xlh.x2f, z3.tlc.t2b.xlh.x2g, z3.tlc.t2b.xlh.x2h, z3.tlc.t2c.xla.x2a, z3.tlc.t2c.xla.x2b, z3.tlc.t2c.xla.x2c, z3.t1c.t2c.xla.x2d, z3.tlc.t2c.xla.x2e, z3.tlc.t2c.xla.x2f, z3.tlc.t2c.x1a.x2g, z3.tlc.t2c.xla.x2h, z3.t1c.t2c.xlb.x2a, z3.tlc.t2c.x1b.x2b, z3.tlc.t2c.xlb.x2c, z3.tlc.t2c.xlb.x2d, z3.tlc.t2c.x1b.x2e, z3.tlc.t2c.xlb.x2f, z3.tlc.t2c.xlb.x2g, z3.tlc.t2c.xlb.x2h, z3.tlc.t2c.xlc.x2a, z3.tlc.t2c.xlc.x2b, z3.tlc.t2c.xlc.x2c, z3.tlc.t2c.xlc.x2d, z3.tlc.t2c.xlc.x2e, z3.tlc.t2c.xlc.x2f, z3.tlc.t2c.xlc.x2g, z3.t1c.t2c.xlc.x2h, z3.tlc.t2c.xld.x2a, z3.tlc.t2c.xld.x2b, z3.tlc.t2c.xld.x2c, z3.tlc.t2c.xld.x2d, z3.tlc.t2c.xld.x2e, z3.t1c.t2c.x1d.x2f, z3.t1c.t2c.x1d.x2g, z3.tlc.t2c.xld.x2h, z3.tlc.t2c.xle.x2a, z3.tlc.t2c.xle.x2b, z3.tlc.t2c.xle.x2c, z3.tlc.t2c.xle.x2d, z3.tlc.t2c.xle.x2e, z3.tlc.t2c.xle.x2f, z3.tlc.t2c.xle.x2g, z3.tlc.t2c.xle.x2h, z3.tlc.t2c.xlf.x2a, z3.tlc.t2c.xlf.x2b, z3.tlc.t2c.xlf.x2c, z3.tlc.t2c.xlf.x2d, z3.tlc.t2c.xlf.x2e, z3.tlc.t2c.xlf.x2f, z3.tlc.t2c.xlf.x2g, z3.tlc.t2c.xlf.x2h, z3.tlc.t2c.xlg.x2a, z3.tlc.t2c.xlg.x2b, z3.tlc.t2c.xlg.x2c, z3.tlc.t2c.xlg.x2d, z3.tlc.t2c.xlg.x2e, z3.tlc.t2c.xlg.x2f, z3.tlc.t2c.xlg.x2g, z3.tlc.t2c.xlg.x2h, z3.tlc.t2c.xlh.x2a, z3.tlc.t2c.xlh.x2b, z3.tlc.t2c.xlh.x2c, z3.tlc.t2c.xlh.x2d, z3.tlc.t2c.xlh.x2e, z3.tlc.t2c.xlh.x2f, z3.t1c.t2c.x1h.x2g, z3.tlc.t2c.xlh.z2h, z3.tlc.t2d.xla.x2a, z3.tlc.t2d.xla.x2b, z3.tlc.t2d.xla.x2c, z3.tlc.t2d.xla.x2d, z3.tlc.t2d.xla.x2e, z3.tlc.t2d.xla.x2f, z3.tlc.t2d.xla.x2g, z3.tlc.t2d.xla.x2h, z3.tlc.t2d.xlb.x2a, z3.tlc.t2d.xlb.x2b, z3.tlc.t2d.xlb.x2c, z3.tlc.t2d.xlb.x2d, z3.tlc.t2d.xlb.x2e, z3.tlc.t2d.xlb.x2f, z3.tlc.t2d.xlb.x2g, z3.tlc.t2d.xlb.x2h, z3.tlc.t2d.xlc.x2a, z3.tlc.t2d.xlc.x2b, z3.tlc.t2d.xlc.x2c, z3.tlc.t2d.xlc.x2d, z3.tlc.t2d.xlc.x2e, z3.tlc.t2d.xlc.x2f, z3.tlc.t2d.xlc.x2g, z3.tlc.t2d.xlc.x2h, z3.t1c.t2d.x1d.x2a, z3.tlc.t2d.xld.x2b, z3.t1c.t2d.xld.x2c, z3.tlc.t2d.xld.x2d, z3.tlc.t2d.xld.x2e, z3.tlc.t2d.xld.x2f, z3.tlc.t2d.xld.x2g, z3.tlc.t2d.xld.x2h, z3.tlc.t2d.xle.x2a, z3.tlc.t2d.xle.x2b, z3.tlc.t2d.xle.x2c, z3.tlc.t2d.xle.x2d, z3.tlc.t2d.xle.x2e, z3.tlc.t2d.xle.x2f, z3.tlc.t2d.xle.x2g, z3.tlc.t2d.xle.x2h, z3.tlc.t2d.xlf.x2a, z3.tlc.t2d.xlf.x2b, z3.tlc.t2d.xlf.x2c, z3.tlc.t2d.xlf.x2d, z3.tlc.t2d.xlf.x2e, z3.tlc.t2d.xlf.x2f, z3.tlc.t2d.xlf.x2g, z3.tlc.t2d.xlf.x2h, z3.tlc.t2d.xlg.x2a, z3.tlc.t2d.xlg.x2b, z3.tlc.t2d.xlg.x2c, z3.tlc.t2d.xlg.x2d, z3.tlc.t2d.xlg.x2e, z3.tlc.t2d.xlg.x2f, z3.tlc.t2d.xlg.x2g, z3.tlc.t2d.xlg.x2h, z3.tlc.t2d.xlh.x2a, z3.tlc.t2d.xlh.x2b, z3.tlc.t2d.xlh.x2c, z3.tlc.t2d.xlh.x2d, z3.tlc.t2d.xlh.x2e, z3.tlc.t2d.xlh.x2f, z3.tlc.t2d.xlh.x2g, z3.tlc.t2d.xlh.x2h, z3.tlc.t2e.xla.x2a, z3.tlc.t2e.xla.x2b, z3.tlc.t2e.xla.x2c, z3.tlc.t2e.xla.x2d, z3.tlc.t2e.xla.x2e, z3.tlc.t2e.xla.x2f, z3.t1c.t2e.xla.x2g, z3.t1c.t2e.x1a.x2h, z3.tlc.t2e.xlb.x2a, z3.tlc.t2e.x1b.x2b, z3.tlc.t2e.xlb.x2c, z3.tlc.t2e.xlb.x2d, z3.tlc.t2e.xlb.x2e, z3.tlc.t2e.xlb.x2f, z3.tlc.t2e.xlb.x2g, z3.t1c.t2e.xlb.x2h, z3.tlc.t2e.xlc.x2a, z3.tlc.t2e.xlc.x2b, z3.tlc.t2e.xlc.x2c, z3.tlc.t2e.xlc.x2d, z3.tlc.t2e.xlc.x2e, z3.tlc.t2e.xlc.x2f, z3.tlc.t2e.xlc.x2g, z3.tlc.t2e.xlc.x2h, z3.tlc.t2e.xld.x2a, z3.tlc.t2e.xld.x2b, z3.tlc.t2e.xld.x2c, z3.tlc.t2e.xld.x2d, z3.tlc.t2e.xld.x2e, z3.tlc.t2e.xld.x2f, z3.tlc.t2e.xld.x2g, z3.tlc.t2e.xld.x2h, z3.tlc.t2e.xle.x2a, z3.tlc.t2e.xle.x2b, z3.tlc.t2e.xle.x2c, z3.tlc.t2e.xle.x2d, z3.tlc.t2e.xle.x2e, z3.tlc.t2e.xle.x2f, z3.tlc.t2e.xle.x2g, z3.tlc.t2e.xle.x2h, z3.tlc.t2e.xlf.x2a, z3.tlc.t2e.xlf.x2b, z3.t1c.t2e.Xlf.x2c, z3.tlc.t2e.xlf.x2d, z3.tlc.t2e.xlf.x2e, z3.tlc.t2e.xlf.x2f, z3.tlc.t2e.xlf.x2g, z3.tlc.t2e.xlf.x2h, z3.tlc.t2e.xlg.x2a, z3.tlc.t2e.xlg.x2b, z3.tlc.t2e.xlg.x2c, z3.tlc.t2e.xlg.x2d, z3.tlc.t2e.xlg.x2e, z3.tlc.t2e.xlg.x2f, z3.tlc.t2e.xlg.x2g, z3.tlc.t2e.xlg.x2h, z3.tlc.t2e.xlh.x2a, z3.tlc.t2e.xlh.x2b, z3.tlc.t2e.xlh.x2c, z3.tlc.t2e.xlh.x2d, z3.tlc.t2e.xlh.x2e, z3.tlc.t2e.xlh.x2f, z3.tlc.t2e.xlh.x2g, z3.tlc.t2e.xlh.x2h, z3.tld.t2a.xla.x2a, z3.t1d.t2a.xla.x2b, z3.tld.t2a.xla.x2c, z3.tld.t2a.xla.x2d, z3.tld.t2a.xla.x2e, z3.tld.t2a.xla.x2f, z3.tld.t2a.xla.x2g, z3.tld.t2a.xla.x2h, z3.tld.t2a.xlb.x2a, z3.tld.t2a.xlb.x2b, z3.tld.t2a.xlb.x2c, z3.tld.t2a.xlb.x2d, z3.tld.t2a.xlb.x2e, z3.tld.t2a.xlb.x2f, z3.tld.t2a.xlb.x2g, z3.t1d.t2a.x1b.x2h, z3.tld.t2a.xlc.x2a, z3.tld.t2a.xlc.x2b, z3.tld.t2a.x1c.x2c, z3.tld.t2a.xlc.x2d, z3.tld.t2a.xlc.x2e, z3.tld.t2a.xlc.x2f, z3.tld.t2a.x1c:x2g, z3.tld.t2a.xlc.x2h, z3.t1d.t2a.xld.x2a, z3.tld.t2a.xld.x2b, z3.tld.t2a.xld.x2c, z3.t1d.t2a.xld.x2d, z3.tld.t2a.xld.x2e, z3.tld.t2a.xld.x2f, z3.tld.t2a.xld.x2g, z3.tld.t2a.xld.x2h, z3.tld.t2a.xle.x2a, z3.tld.t2a.xle.x2b, z3.tld.t2a.xle.x2c, z3.tld.t2a.xle.x2d, z3.tld.t2a.xle.x2e, z3.tld.t2a.xle.x2f, z3.tld.t2a.xle.x2g, z3.tld.t2a.xle.x2h, z3.t1d.t2a.xlf.x2a, z3.tld.t2a.xlf.x2b, z3.tld.t2a.x1f.x2c, z3.tld.t2a.xlf.x2d, z3.tld.t2a.x1f.x2e, z3.tld.t2a.xlf.x2f, z3.tld.t2a.xlf.x2g, z3.tld.t2a.xlf.x2h, z3.tld.t2a.xlg.x2a, z3.tld.t2a.xlg.x2b, z3.tld.t2a.xlg.x2c, z3.tld.t2a.xlg.x2d, z3.tld.t2a.xlg.x2e, z3.tld.t2a.xlg.x2f, z3.tld.t2a.xlg.x2g, z3.tld.t2a.xlg.x2h, z3.tld.t2a.xlh.x2a, z3.tld.t2a.xlh.x2b, z3.tld.t2a.xlh.x2c, z3.tld.t2a.xlh.x2d, z3.tld.t2a.xlh.x2e, z3.t1d.t2a.xlh.x2f, z3.tld.t2a.xlh.x2g, z3.t1d.t2a.x1h.x2h, z3.t1d.t2b.xla.x2a, z3.tld.t2b.xla.x2b, z3.tld.t2b.xla.x2c, z3.tld.t2b.xla.x2d, z3.tld.t2b.xla.x2e, z3.t1d.t2b.xla.x2f, z3.tld.t2b.xla.x2g, z3.tld.t2b.xla.x2h, z3.tld.t2b.xlb.x2a, z3.tld.t2b.xlb.x2b, z3.tld.t2b.xlb.x2c, z3.tld.t2b.xlb.x2d, z3.tld.t2b.xlb.x2e, z3.tld.t2b.xlb.x2f, z3.tld.t2b.xlb.x2g, z3.tld.t2b.xlb.x2h, z3.tld.t2b.xlc.x2a, z3.tld.t2b.xlc.x2b, z3.tld.t2b.xlc.x2c, z3.tld.t2b.xlc.x2d, z3.tld.t2b.xlc.x2e, z3.tld.t2b.xlc.x2f, z3.tld.t2b.xlc.x2g, z3.tld.t2b.xlc.x2h, z3.tld.t2b.xld.x2a, z3.tld.t2b.xld.x2b, z3.tld.t2b.xld.x2c, z3.tld.t2b.xld.x2d, z3.t1d.t2b.x1d.x2e, z3.tld.t2b.xld.x2f, z3.tld.t2b.xld.x2g, z3.tld.t2b.x1d.x2h, z3.tld.t2b.xle.x2a, z3.tld.t2b.xle.x2b, z3.tld.t2b.xle.x2c, z3.tld.t2b.xle.x2d, z3.tld.t2b.xle.x2e, z3.tld.t2b.xle.x2f, z3.tld.t2b.xle.x2g, z3.tld.t2b.xle.x2h, z3.tld.t2b.xlf.x2a, z3.tld.t2b.xlf.x2b, z3.tld.t2b.xlf.x2c, z3.tld.t2b.xlf.x2d, z3.tld.t2b.xlf.x2e, z3.tld.t2b.xlf.x2f, z3.tld.t2b.xlf.x2g, z3.tld.t2b.xlf.x2h, z3.tld.t2b.xlg.x2a, z3.tld.t2b.xlg.x2b, z3.t1d.t2b.xlg.x2c, z3.tld.t2b.xlg.x2d, z3.tld.t2b.xlg.x2e, z3.tld.t2b.xlg.x2f, z3.tld.t2b.xlg.x2g, z3.tld.t2b.xlg.x2h, z3.tld.t2b.xlh.x2a, z3.tld.t2b.xlh.x2b, z3.tld.t2b.xlh.x2c, z3.tld.t2b.xlh.x2d, z3.tld.t2b.xlh.x2e, z3.tld.t2b.xlh.x2f, z3.tld.t2b.xlh.x2g, z3.tld.t2b.xlh.x2h, z3.tld.t2c.xla.x2a, z3.tld.t2c.xla.x2b, z3.tld.t2c.xla.x2c, z3.tld.t2c.xla.x2d, z3.tld.t2c.xla.x2e, z3.tld.t2c.xla.x2f, z3.tld.t2c.xla.x2g, z3.tld.t2c.xla.x2h, z3.tld.t2c.xlb.x2a, z3.tld.t2c.xlb.x2b, z3.tld.t2c.xlb.x2c, z3.tld.t2c.xlb.x2d, z3.tld.t2c.xlb.x2e, z3.tld.t2c.x1b.x2f,*z3.t1d.t2c.xlb.x2g, z3.tld.t2c.xlb.x2h, z3.tld.t2c.xlc.x2a, z3.tld.t2c.xlc.x2b, z3.tld.t2c.xlc.x2c, z3.tld.t2c.xlc.x2d, z3.tld.t2c.xlc.x2e, z3.tld.t2c.xlc.x2f, z3.tid.t2c.xlc.x2g, z3.tld.t2c.xlc.x2h, z3.tld.t2c.xld.x2a, z3.tld.t2c.xld.x2b, z3.tld.t2c.xld.x2c, z3.tld.t2c.xld.x2d, z3.tld.t2c.xld.x2e, z3.tld.t2c.xld.x2f, z3.tld.t2c.xld.x2g, z3.tld.t2c.xld.x2h, z3.tld.t2c.xle.x2a, z3.tld.t2c.xle.x2b, z3.t1d.t2c.x1e.x2c, z3.tld.t2c.xle.x2d, z3.tld.t2c.xle.x2e, z3.tld.t2c.xle.x2f, z3.tld.t2c.xle.x2g, z3.tld.t2c.xle.x2h, z3.tld.t2c.xlf.x2a, z3.tld.t2c.xlf.x2b, z3.tld.t2c.xlf.x2c, z3.tld.t2c.xlf.x2d, z3.tld.t2c.xlf.x2e, z3.tld.t2c.xlf.x2f, z3.tld.t2c.xlf.x2g, z3.tld.t2c.xlf.x2h, z3.t1d.t2c.xlg.x2a, z3.tld.t2c.xlg.x2b, z3.tld.t2c.xlg.x2c, z3.tld.t2c.xlg.x2d, z3.tld.t2c.xlg.x2e, z3.t1d.t2c.xlg.x2f, z3.tld.t2c.xlg.x2g, z3.tld.t2c.xlg.x2h, z3.tld.t2c.xlh.x2a, z3.tld.t2c.xlh.x2b, z3.tld.t2c.xlh.x2c, z3.tld.t2c.xlh.x2d, z3.tld.t2c.xlh.x2e, z3.tld.t2c.xlh.x2f, z3.tld.t2c.xlh.x2g, z3.t1d.t2c.xlh.x2h, z3.tld.t2d.x1a.x2a, z3.tld.t2d.xla.x2b, z3.tld.t2d.xla.x2c, z3.tld.t2d.xla.x2d, z3.tld.t2d.xla.x2e, z3.tld.t2d.xla.x2f, z3.tld.t2d.xla.x2g, z3.tld.t2d.xla.x2h, z3.tld.t2d.xlb.x2a, z3.tld.t2d.xlb.x2b, z3.t1d.t2d.xlb.x2c, z3.tld.t2d.xlb.x2d, z3.tld.t2d.xlb.x2e, z3.tld.t2d.xlb.x2f, z3.tld.t2d.xlb.x2g, z3.tld.t2d.xlb.x2h, z3.tld.t2d.x1c.x2a, z3.tld.t2d.xlc.x2b, z3.tld.t2d.xlc.x2c, z3.tld.t2d.xlc.x2d, z3.tld.t2d.xlc.x2e, z3.tld.t2d.xlc.x2f, z3.tld.t2d.xlc.x2g, z3.tld.t2d.xlc.x2h, z3.tld.t2d.xld.x2a, z3.tld.t2d.xld.x2b, z3.tld.t2d.xld.x2c, z3.tld.t2d.xld.x2d, z3.tld.t2d.xld.x2e, z3.tld.t2d.xld.x2f, z3.tld.t2d.xld.x2g, z3.tld.t2d.xld.x2h, z3.tld.t2d.xle.x2a, z3.tld.t2d.xle.x2b, z3.t1d.t2d.x1e.x2c, z3.tld.t2d.xle.x2d, z3.tld.t2d.xle.x2e, z3.tld.t2d.xle.x2f, z3.t1d.t2d.xle.x2g, z3.tld.t2d.xle.x2h, z3.t1d.t2d.xlf.x2a, z3.tld.t2d.xlf.x2b, z3.tld.t2d.xlf.x2c, z3.tld.t2d.xlf.x2d, z3.tld.t2d.xlf.x2e, z3.tld.t2d.xlf.x2f, z3.tld.t2d.xlf.x2g, z3.tld.t2d:xlf.x2h, z3.tld.t2d.x1g.x2a, z3.tld.t2d.xlg.x2b, z3.tld.t2d.xlg.x2c, z3.tld.t2d.xlg.x2d, z3.tld.t2d.xlg.x2e, z3.tld.t2d.xlg.x2f, z3.tld.t2d.xlg.x2g;
z3.tld.t2d.xlg.x2h, z3.tld.t2d.xlh.x2a, z3.tld.t2d.xlh.x2b, z3.tld.t2d.xlh.x2c, z3.tld.t2d.xlh.x2d, z3.tld.t2d.xlh.x2e, z3.tld.t2d.xlh.x2f, z3.tld.t2d.xlh.x2g, z3.tld.t2d.xlh.x2h, z3.tld.t2e.x1a.x2a, z3.t1d.t2e.xl-a.x2b, z3.tld.t2e.xla.x2c, z3.tld.t2e.xla.x2d, z3.tld.t2e.xla.x2e, z3.tld.t2e.xla.x2f, z3.tld.t2e.xla.x2g, z3.tld.t2e.xla.x2h, z3.tld.t2e.xlb.x2a, z3.t1d.t2e.xlb.x2b, z3.tld.t2e.xlb.x2c, z3.tld.t2e.xlb.x2d, z3.tld.t2e.xlb.x2e, z3.tld.t2e.xlb.x2f, z3.tld.t2e.xlb.x2g, z3.tld.t2e.xlb.x2h, z3.tld.t2e.xlc.x2a, z3.tld.t2e.xlc.x2b, z3.tld.t2e.xlc.x2c, z3.tld.t2e.xlc.x2d, z3.tld.t2e.xlc.x2e, z3.tld.t2e.xlc.x2f, z3.tld.t2e.xlc.x2g, z3.tld.t2e.xlc.x2h, z3.tld.t2e.xld.x2a, z3.tld.t2e.xld.x2b, z3.tld.t2e.xld.x2c, z3.tld.t2e.xld.x2d, z3.tld.t2e.xld.x2e, z3.tld.t2e.xld.x2f, z3.tld.t2e.xld.x2g, z3.tld.t2e.x1d.x2h, z3.tld.t2e.xle.x2a, z3.tld.t2e.x1e.x2b, z3.tld.t2e.xle.x2c, z3.tld.t2e.xle.x2d, z3.tld.t2e.xle.x2e, z3.tld.t2e.xle.x2f, z3.tld.t2e.xle.x2g, z3.tld.t2e.xle.x2h, z3.tld.t2e.xlf.x2a, z3.tld.t2e.xlf.x2b, z3.t1d.t2e.xlf.x2c, z3.t1d.t2e.xlf.x2d, z3.tld.t2e.xlf.x2e, z3.tld.t2e.xlf.x2f, z3.tld.t2e.xlf.x2g, z3.tld.t2e.xlf.x2h, z3.tld.t2e.xlg.x2a, z3.tld.t2e.xlg.x2b, z3.tld.t2e.xlg.x2c, z3.tld.t2e.xlg.x2d, z3.tld.t2e.xlg.x2e, z3.tld.t2e.xlg.x2f, z3.tld.t2e.xlg.x2g, z3.tld.t2e.xlg.x2h, z3.tld.t2e.xlh.x2a, z3.tld.t2e.xlh.x2b, z3.tld.t2e.xlh.x2c, z3.tld.t2e.xlh.x2d, z3.tld.t2e.xlh.x2e, z3.tld.t2e.xlh.x2f, z3.tld.t2e.xlh.x2g, z3.tld.t2e.xlh.x2h, z3.tle.t2a.xla.x2a, z3.tle.t2a.xla.x2b, z3.tle.t2a.xla.x2c, z3.tle.t2a.xla.x2d, z3.tle.t2a.xla.x2e, z3.tle.t2a.xla.x2f, z3.tle.t2a.x1a.x2g, z3.tle.t2a.xla.x2h, z3.tle.t2a.xlb.x2a, z3.tle.t2a.xlb.x2b, z3.tle.t2a.xlb.x2c, z3.tle.t2a.xlb.x2d, z3.tle.t2a.xlb.x2e, z3.tle.t2a.xlb.x2f, z3.tle.t2a.xlb.x2g, z3.tle.t2a.xlb.x2h, z3.tle.t2a.xlc.x2a, z3.tle.t2a.xlc.x2b, z3.tle.t2a.xlc.x2c, z3.tle.t2a.xlc.x2d, z3.t1e.t2a.xlc.x2e, z3.tle.t2a.xlc.x2f, z3.tle.t2a.xlc.x2g, z3.tle.t2a.xlc.x2h, z3.tle.t2a.xld.x2a, z3.tle.t2a.xld.x2b, z3.tle.t2a.xld.x2c, z3.tle.t2a.zld.x2d, z3.tle.t2a.xld.x2e, z3.tle.t2a.xld.x2f, z3.tle.t2a.xld.x2g, z3.tle.t2a.xld.x2h, z3.tle.t2a.xle.x2a, z3.tle.t2a.xle.x2b, z3.tle.t2a.xle.x2c, z3.tle.t2a.xle.x2d, z3.tle.t2a.xle.x2e, z3.tle.t2a.xle.x2f, z3.tle.t2a.xle.x2g, z3.tle.t2a.xle.x2h, z3.tle.t2a.xlf.x2a, z3.tle.t2a:xlf.x2b, z3.tle.t2a.xlf.x2c, z3.tle.t2a.xlf.x2d, z3.tle.t2a.xlf.x2e, z3.tle.t2a.xlf.x2f, z3.tle.t2a.xlf.x2g, z3.tle.t2a.xlf.x2h, z3.tle.t2a.xlg.x2a, z3.tle.t2a.xlg.x2b, z3.tle.t2a.xlg.x2c, z3.tle.t2a.xlg.x2d, z3.tle.t2a.xlg.x2e, z3.tle.t2a.xlg.x2f, z3.tle.t2a.xlg.x2g, z3.tle.t2a.xlg.x2h, z3.tle.t2a.xlh.x2a, z3.tle.t2a.xlh.x2b, z3.tle.t2a.xlh.x2c, z3.tle.t2a.xlh.x2d, z3.tle.t2a.xlh.x2e, z3.tle.t2a.xlh.x2f, z3.tle.t2a.xlh.x2g, z3.tle.t2a.xlh.x2h, z3.tle.t2b.xla.x2a, z3.tle.t2b.xla.x2b, z3.tle.t2b.xla.x2c, z3.tle.t2b.xla.x2d, z3.tle.t2b.xla.x2e, z3.tle.t2b.xla.x2f, z3.tle.t2b.xla.x2g, z3.tle.t2b.xla.x2h, z3.tle.t2b.xlb.x2a, z3.tle.t2b.xlb.x2b, z3.tle.t2b.xlb.x2c, z3.tle.t2b.xlb.x2d, z3.tle.t2b.xlb.x2e, z3.tle.t2b.xlb.x2f, z3.tle.t2b.xlb.x2g, z3.tle.t2b.xlb.x2h, z3.tle.t2b.xlc.x2a, z3.tle.t2b.xlc.x2b, z3.tle.t2b.xlc.x2c, z3.tle.t2b.xlc.x2d, z3.tle.t2b.xlc.x2e, z3.tle.t2b.xlc.x2f, z3.tle.t2b.xlc.x2g, z3.tle.t2b.xlc.x2h, z3.tle.t2b.xld.x2a, z3.tle.t2b.xld.x2b, z3.t1e.t2b.xld.x2c, z3.t1e.t2b.xld.x2d, z3.tle.t2b.xld.x2e, z3.tle.t2b.xld.x2f, z3.tle.t2b.xld.x2g, z3.t1e.t2b.x1d.x2h, z3.tle.t2b.xle.x2a, z3.tle.t2b.xle.x2b, z3.tle.t2b.xle.x2c, z3.tle.t2b.xle.x2d, z3.tle.t2b.xle.x2e, z3.tle.t2b.xle.x2f, z3.tle.t2b.xle.x2g, z3.tle.t2b.xle.x2h, z3.tle.t2b.x1f.x2a, z3.t1e.t2b.xlf.x2b, z3.tle.t2b.xlf.x2c, z3.tle.t2b.xlf.x2d, z3.tle.t2b.x1f.x2e, z3.tle.t2b.xlf.x2f, z3.tle.t2b.xlf.x2g, z3.tle.t2b.xlf.x2h, z3.tle.t2b.xlg.x2a, z3.tle.t2b.xlg.x2b, z3.tle.t2b.xlg.x2c, z3.tle.t2b.xlg.x2d, z3.tle.t2b.xlg.x2e, z3.tle.t2b.xlg.x2f, z3.tle.t2b.xlg.x2g, z3.tle.t2b.xlg.x2h, z3.tle.t2b.xlh.x2a, z3.tle.t2b.xlh.x2b, z3.tle.t2b.xlh.x2c, z3.tle.t2b.xlh.x2d, z3.tle.t2b.xlh.x2e, z3.tle.t2b.xlh.x2f, z3.tle.t2b.xlh.x2g, z3.tle.t2b.xlh.x2h, z3.tle.t2c.xla.x2a, z3.tle.t2c.xla.x2b, z3.tle.t2c.xla.x2c, z3.tle.t2c.xla.x2d, z3.tle.t2c.xla.x2e, z3.tle.t2c.xla.x2f, z3.tle.t2c.xla.x2g, z3.tle.t2c.xla.x2h, z3.tle.t2c.xlb.x2a, z3.tle.t2c.xlb.x2b, z3.tle.t2c.xlb.x2c, z3.tle.t2c.xlb.x2d, z3.tle.t2c.xlb.x2e, z3.tle.t2c.xlb.x2f, z3.tle.t2c.xlb.x2g, z3.tle.t2c.xlb.x2h, z3.tle.t2c.xlc.x2a, z3.tle.t2c.xlc.x2b, z3.tle.t2c.xlc.x2c, z3.tle.t2c.xlc.x2d, z3.tle.t2c.xlc.x2e, z3.tle.t2c.xlc.x2f, z3.tle.t2c.xlc.x2g, z3.tle.t2c.xlc.x2h, z3.t1e.t2c.x1d.x2a, z3.tle.t2c.xld.x2b, z3.tle.t2c.xld.x2c, z3.tle.t2c.xld.x2d, z3.tle.t2c.xld.x2e, z3.tle.t2c.xld.x2f, z3.tle.t2c.xld.x2g, z3.tle.t2c.xld.x2h, z3.tle.t2c.xle.x2a, z3.tle.t2c.xle.x2b, z3.tle.t2c.xle.x2c, z3.tle.t2c.xle.x2d, z3.tle.t2c.xle.x2e, z3.tle.t2c.xle.x2f, z3.tle.t2c.xle.x2g, z3.tle.t2c.xle.x2h, z3.tle.t2c.xlf.x2a, z3.tle.t2c.xlf.x2b, z3.tle.t2c.xlf.x2c, z3.tle.t2c.xlf.x2d, z3.tle.t2c.xlf.x2e, z3.tle.t2c.xlf.x2f, z3.tle.t2c.xlf.x2g, z3.tle.t2c.xlf.x2h, z3.tle.t2c.xlg.x2a, z3.tle.t2c.xlg.x2b, z3.tle.t2c.xlg.x2c, z3.tle.t2c.xlg.x2d, z3.tle.t2c.xlg.x2e, z3.tle.t2c.xlg.x2f, z3.tle.t2c.xlg.x2g, z3.tle.t2c.xlg.x2h, z3.tle.t2c.xlh.x2a, z3.tle.t2c.x1h.x2b, z3.tle.t2c.xlh.x2c, z3.tle.t2c.xlh.x2d, z3.tle.t2c.xlh.x2e, z3.tle.t2c.xlh.x2f, z3.tle.t2c.xlh.x2g, z3.tle.t2c.xlh.x2h, z3.tle.t2d.xla.x2a, z3.tle.t2d.xla.x2b, z3.tle.t2d.xla.x2c, z3.t1e.t2d.xla.x2d, z3.tle.t2d.xla.x2e, z3.tle.t2d.xla.x2f, z3.tle.t2d.xla.x2g, z3.tle.t2d.xla.x2h, z3.tle.t2d.x1b.x2a, z3.tle.t2d.xlb.x2b, z3.tle.t2d.x1b.x2c, z3.t1e.t2d.xlb.x2d, z3.tle.t2d.xlb.x2e, z3.t1e.t2d.xlb.x2f, z3.tle.t2d.xlb.x2g, z3.tle.t2d.xlb.x2h, z3.tle.t2d.xlc.x2a, z3.tle.t2d.xlc.x2b, z3.tle.t2d.xlc.x2c, z3.tle.t2d.xlc.x2d, z3.tle.t2d.xlc.x2e, z3.tle.t2d.xlc.x2f, z3.tle.t2d.xlc.x2g, z3.tle.t2d.xlc.x2h, z3.tle.t2d.xld.x2a, z3.tle.t2d.xld.x2b, z3.tle.t2d.xld.x2c, z3.tle.t2d.xld.x2d, z3.tle.t2d.xld.x2e, z3.t1e.t2d.x1d.x2f, z3.tle.t2d.xld.x2g, z3.tle.t2d.xld.x2h, z3.t1e.t2d.xle.x2a, z3.tle.t2d.xle.x2b, z3.tle.t2d.xle.x2c, z3.tle.t2d.xle.x2d, z3.tle.t2d.xle.x2e, z3.t1e.t2d.x1e.x2f, z3.t1e.t2d.x1e.x2g, z3.tle.t2d.xle.x2h, z3.t1e.t2d.x1f.x2a, z3.tle.t2d.xlf.x2b, z3.tle.t2d.xlf.x2c, z3.tle.t2d.xlf.x2d, z3.tle.t2d.xlf.x2e, z3.tle.t2d.xlf.x2f, z3.tle.t2d.xlf.x2g, z3.tle.t2d.xlf.x2h, z3.tle.t2d.xlg.x2a, z3.tle.t2d.xlg.x2b, z3.tle.t2d.xlg.x2c, z3.tle.t2d.xlg.x2d, z3.tle.t2d.xlg.x2e, z3.tle.t2d.xlg.x2f, z3.tle.t2d.xlg.x2g, z3.tle.t2d.xlg.x2h, z3.tle.t2d.xlh.x2a, z3.tle.t2d.xlh.x2b, z3.tle.t2d.xlh.x2c, z3.tle.t2d.xlh.x2d, z3.tle.t2d.xlh.x2e, z3.tle.t2d.xlh.x2f, z3.tle.t2d.xlh.x2g, z3.t1e.t2d.xlh.x2h, z3.tle.t2e.xla.x2a, z3.tle.t2e.xla.x2b, z3.tle.t2e.xla.x2c, z3.tle.t2e.xla.x2d, z3.tle.t2e.xla.x2e, z3.tle.t2e.xla.x2f, z3.tle.t2e.xla.x2g, z3.tle.t2e.xla.x2h, z3.tle.t2e.xlb.x2a, z3.tle.t2e.xlb.x2b, z3.tle.t2e.xlb.x2c, z3.tle.t2e.xlb.x2d, z3.tle.t2e.xlb.x2e, z3.tle.t2e.xlb.x2f, z3.tle.t2e.xlb.x2g, z3.tle.t2e.xlb.x2h, z3.tle.t2e.xlc.x2a, z3.tle.t2e.xlc.x2b, z3.tle.t2e.xlc.x2c, z3.tle.t2e.xlc.x2d, z3.tle.t2e.xlc.x2e, z3.tle.t2e.xlc.x2f, z3.tle.t2e.xlc.x2g, z3.tle.t2e.xlc.x2h, z3.tle.t2e.xld.x2a, z3.tle.t2e.xld.x2b, z3.tle.t2e.xld.x2c, z3.tle.t2e.xld.x2d, z3.tle.t2e.xld.x2e, z3.tle.t2e.xld.x2f, z3.tle.t2e.xld.x2g, z3.tle.t2e.xld.x2h, z3.tle.t2e.xle.x2a, z3.tle.t2e.xle.x2b, z3.tle.t2e.xle.x2c, z3.tle.t2e.xle.x2d, z3.tle.t2e.xle.x2e, z3.tle.t2e.xle.x2f, z3.tle.t2e.xle.x2g, z3.tle.t2e.xle.x2h, z3.tle.t2e.xlf.x2a, z3.tle.t2e.xlf.x2b, z3.tle.t2e.xlf.x2c, z3.tle.t2e.xlf.x2d, z3.tle.t2e.xlf.x2e, z3.tle.t2e.xlf.x2f, z3.tle.t2e.xlf.x2g, z3.tle.t2e.xlf.x2h, z3.tle.t2e.xlg.x2a, z3.tle.t2e.xlg.x2b, z3.tle.t2e.xlg.x2c, z3.tle.t2e.xlg.x2d, z3.tle.t2e.xlg.x2e, z3.tle.t2e.xlg.x2f, z3.tle.t2e.xlg.x2g, z3.t1e.t2e.xlg.x2h, z3.tle.t2e.xlh.x2a, z3.tle.t2e.xlh.x2b, z3.tle.t2e.xlh.x2c, z3.tle.t2e.xlh.x2d, z3.tle.t2e.xlh.x2e, z3.tle.t2e.xlh.x2f, z3.tle.t2e.xlh.x2g, z3.tle.t2e.xlh.x2h, z4.tla.t2a.xla.x2a, z4.tla.t2a.xla.x2b, z4.tla.t2a.xla.x2c, z4.tla.t2a.x1a.x2d, z4.tla.t2a.xla.x2e, z4.tla.t2a.xla.x2f, z4.tla.t2a.xla.x2g, z4.tla.t2a.xla.x2h, z4.tla.t2a.xlb.x2a, z4.tla.t2a.xlb.x2b, z4.tla.t2a.xlb.x2c, z4.tla.t2a.xlb.x2d, z4.tla.t2a.xlb.x2e, z4.tla.t2a.xlb.x2f, z4.tla.t2a.xlb.x2g, z4.tla.t2a.xlb.x2h, z4.tla.t2a.xlc.x2a, z4.tla.t2a.xlc.x2b, z4.tla.t2a.xlc.x2c, z4.tla.t2a.xlc.x2d, z4.tla.t2a.xlc.x2e, z4.tla.t2a.xlc.x2f, z4.tla.t2a.xlc.x2g, z4.tla.t2a.xlc.x2h, z4.tla.t2a.xld.x2a, z4.tla.t2a.xld.x2b, z4.tla.t2a.xld.x2c, z4.tla.t2a.x1d.x2d, z4.tla.t2a.xld.x2e, z4.tla.t2a.xld.x2f, z4.tla.t2a.xld.x2g, z4.tla.t2a.xld.x2h, z4.tla.t2a.xle.x2a, z4.tla.t2a.xle.x2b, z4.tla.t2a.xle.x2c, z4.tla.t2a.xle.x2d, z4.tla.t2a.xle.x2e, z4.tla.t2a.xle.x2f, z4.tla.t2a.xle.x2g, z4.tla.t2a.xle.x2h, z4.tla.t2a.xlf.x2a, z4.tla.t2a.xlf.x2b, z4.tla.t2a.xlf.x2c, z4.tla.t2a.xlf.x2d, z4.tla.t2a.xlf.x2e, z4.tla.t2a.xlf.x2f, z4.tla.t2a.xlf.x2g, z4.tla.t2a.xlf.x2h, z4.tla.t2a.xlg.x2a, z4.tla.t2a.xlg.x2b, z4.tla.t2a.xlg.x2c, z4.tla.t2a.xlg.x2d, z4.tla.t2a.xlg.x2e, z4.tla.t2a.xlg.x2f, z4.tla.t2a.xlg.x2g, z4.tla.t2a.xlg.x2h, z4.tla.t2a.xlh.x2a, z4.tla.t2a.xlh.x2b, z4.tla.t2a.xlh.x2c, z4.tla.t2a.xlh.x2d, z4.tla.t2a.xlh.x2e, z4.tla.t2a.xlh.x2f, z4.tla.t2a.xlh.x2g, z4.tla.t2a.xlh.x2h, z4.tla.t2b.xla.x2a, z4.tla.t2b.xla.x2b, z4.tla.t2b.xla.x2c, z4.tla.t2b.xla.x2d, z4.tla.t2b.xla.x2e, z4.tla.t2b.xla.x2f, z4.tla.t2b.xla.x2g, z4.tla.t2b.xla.x2h, z4.tla.t2b.xlb.x2a, z4.tla.t2b.xlb.x2b, z4.tla.t2b.xlb.x2c, z4.tla.t2b.xlb.x2d, z4.tla.t2b.xlb.x2e, z4.tla.t2b.xlb.x2f, z4.tla.t2b.xlb.x2g, z4.tla.t2b.xlb.x2h, z4.tla.t2b.xlc.x2a, z4.tla.t2b.xlc.x2b, z4.tla.t2b.xlc.x2c, z4.tla.t2b.xlc.x2d, z4.tla.t2b.xlc.x2e, z4.tla.t2b.xlc.x2f, z4.tla.t2b.xlc.x2g, z4.tla.t2b.xlc.x2h, z4.tla.t2b.xld.x2a, z4.tla.t2b.xld.x2b, z4.tla.t2b.xld.x2c, z4.tla.t2b.xld.x2d, z4.tla.t2b.xld.x2e, z4.tla.t2b.xld.x2f, z4.tla.t2b.x1d.x2g, z4.tla.t2b.xld.x2h, z4.tla.t2b.xle.x2a, z4.tla.t2b.xle.x2b, z4.tla.t2b.xle.x2c, z4.tla.t2b.xle.x2d, z4.tla.t2b.xle.x2e, z4.tla.t2b.xle.x2f, z4.tla.t2b.xle.x2g, z4.tla.t2b.xle.x2h, z4.tla.t2b.xlf.x2a, z4.tla.t2b.xlf.x2b, z4.tla.t2b.xlf.x2c, z4.tla.t2b.xlf.x2d, z4.tla.t2b.xlf.x2e, z4.tla.t2b.xlf.x2f, z4.tla.t2b.xlf.x2g, z4.tla.t2b.xlf.x2h, z4.tla.t2b.xlg.x2a, z4.tla.t2b.xlg.x2b, z4.tla.t2b.xlg.x2c, z4.tla.t2b.xlg.x2d, z4.tla.t2b.xlg.x2e, z4.tla.t2b.xlg.x2f, z4.tla.t2b.xlg.x2g, z4.t1a.t2b.xlg.x2h, z4.tla.t2b.xlh.x2a, z4.tla.t2b.xlh.x2b, z4.tla.t2b.xlh.x2c, z4.tla.t2b.xlh.x2d, z4.tla.t2b.xlh.x2e, z4.tla.t2b.xlh.x2f, z4.tla.t2b.xlh.x2g, z4.tla.t2b.xlh.x2h, z4.tla.t2c.xla.x2a, z4.tla.t2c.xla.x2b, z4.tla.t2c.xla.x2c, z4.tla.t2c.xla.x2d, z4.tla.t2c.x1a.x2e, z4.tla.t2c.xla.x2f, z4.tla.t2c.xla.x2g, z4.tla_t2c.xla.x2h, z4.tla.t2c.xlb.x2a, z4.tla.t2c.xlb.x2b, z4.tla.t2c.xlb.x2c, z4.tla.t2c.xlb.x2d, z4.tla.t2c.xlb.x2e, z4.tla.t2c.xlb.x2f, z4.tla.t2c.xlb.x2g, z4.tla.t2c.xlb.x2h, z4.tla.t2c.xlc.x2a, z4.tla.t2c.xlc.x2b, z4.tla.t2c.xlc.x2c, z4.tla.t2c.xlc.x2d, z4.tla.t2c.xlc.x2e, z4.tla.t2c:xlc.x2f, z4.tla.t2c.xlc.x2g, z4.tla.t2c.xlc.x2h, z4.tla.t2c.xld.x2a, z4.tla.t2c.xld.x2b, z4.tla.t2c.xld.x2c, z4.tla.t2c.xld.x2d, z4.tla.t2c.xld.x2e, z4.tla.t2c.x1d.x2f, z4.tla.t2c.xld.x2g, z4.tla.t2c.xld.x2h, z4.tla.t2c.xle.x2a, z4.tla.t2c.xle.x2b, z4.tla.t2c.xle.x2c, z4.tla.t2c.xle.x2d, z4.tla.t2c.xle.x2e, z4.tla.t2c.xle.x2f, z4.tla.t2c.xle.x2g, z4.tla.t2c.xle.x2h, z4.tla.t2c.xlf.x2a, z4.t1a.t2c.xlf.x2b, z4.tla.t2c.xlf.x2c, z4.tla.t2c.xlf.x2d, z4.t1a.t2c.xlf.x2e, z4.tla.t2c.xlf.x2f, z4.tla.t2c.xlf.x2g, z4.tla.t2c.xlf.x2h, z4.tla.t2c.xlg.x2a, z4.tla.t2c.xlg.x2b, z4.tla.t2c.xlg.x2c, z4.tla.t2c.xlg.x2d, z4.tla.t2c.xlg.x2e, z4.tla.t2c.xlg.x2f, z4.tla.t2c.xlg.x2g, z4.tla.t2c.xlg.x2h, z4.tla.t2c.xlh.x2a, z4.tla.t2c.xlh.x2b, z4.tla.t2c.xlh.x2c, z4.tla.t2c.xlh.x2d, z4.tla.t2c.xlh.x2e, z4.tla.t2c.xlh.x2f, z4.tla.t2c.xlh.x2g, z4.tla.t2c.xlh.x2h, z4.tla.t2d.xla.x2a, z4.tla.t2d.xla.x2b, z4.tla.t2d.xla.x2c, z4.tla.t2d.xla.x2d, z4.tla.t2d.xla.x2e, z4.tla.t2d.xla.x2f, z4.tla.t2d.xla.x2g, z4.tla.t2d.xla.x2h, z4.tla.t2d.xlb.x2a, z4.tla.t2d.xlb.x2b, z4.tla.t2d.xlb.x2c, z4.tla.t2d.xlb.x2d, z4.tla.t2d.xlb.x2e, z4.tla.t2d.xlb.x2f, z4.tla.t2d.xlb.x2g, z4.tla.t2d.xlb.x2h, z4.tla.t2d.xlc.x2a, z4.tla.t2d.xlc.x2b, z4.tla.t2d.xlc.x2c, z4.tla.t2d.xlc.x2d, z4.tla.t2d.xlc.x2e, z4.tla.t2d.xlc.x2f, z4.tla.t2d.xlc.x2g, z4.tla.t2d.xlc.x2h, z4.tla.t2d.xld.x2a, z4.tla.t2d.xld.x2b, z4.tla.t2d.xld.x2c, z4.tla.t2d.xld.x2d, z4.tla.t2d.xld.x2e, z4.tla.t2d.xld.x2f, z4.tla.t2d.xld.x2g, z4.tla.t2d.xld.x2h, z4.tla.t2d.xle.x2a, z4.tla.t2d.xle.x2b, z4.t1a.t2d.xle.x2c, z4.tla.t2d.xle.x2d, z4.tla.t2d.xle.x2e, z4.tla.t2d.xle.x2f, z4.tla.t2d.x1e.x2g, z4.tla.t2d.x1e.x2h, z4.tla.t2d.xlf.x2a, z4.tla.t2d.xlf.x2b, z4.tla.t2d.xlf.x2c, z4.tla.t2d.xlf.x2d, z4.tla.t2d.xlf.x2e, z4.tla.t2d.xlf.x2f, z4.tla.t2d.xlf.x2g, z4.tla.t2d.xlf.x2h, z4.tla.t2d.xlg.x2a, z4.tla.t2d.xlg.x2b, z4.tla.t2d.xlg.x2c, z4.tla.t2d.xlg.x2d, z4.tla.t2d.xlg.x2e, z4.tla.t2d.xlg.x2f, z4.tla.t2d.xlg.x2g, z4.tla.t2d.xlg.x2h, z4.tla.t2d.xlh.x2a, z4.tla.t2d.x1h.x2b, z4.tla.t2d.xlh.x2c, z4.tla.t2d.xlh.x2d, z4.tla.t2d.xlh.x2e, z4.tla.t2d.xlh.x2f, z4.tla.t2d.xlh.x2g, z4.tla.t2d.xlh.x2h, z4.tla.t2e.x1a.x2a, z4.tla.t2e.xla.x2b, z4.tla.t2e.xla.x2c, z4.tla.t2e.x1a.x2d, z4.tla.t2e.xla.x2e, z4.t1a.t2e.x1a.x2f, z4.tla.t2e.xla.x2g, z4.t1a.t2e.xla.x2h, z4.tla.t2e.xlb.x2a, z4.tla.t2e.xlb.x2b, z4.tla.t2e.xlb.x2c, z4.tla.t2e.xlb.x2d, z4.tla.t2e.xlb.x2e, z4.tla.t2e.xlb.x2f, z4.tla.t2e.xlb.x2g, z4.tla.t2e.xlb.x2h, z4.tla.t2e.xlc.x2a, z4.tla.t2e.xlc.x2b, z4.tla.t2e.xlc.x2c, z4.tla.t2e.x1c.x2d, z4.tla.t2e.xlc.x2e, z4.tla.t2e.xlc.x2f, z4.tla.t2e.x1c.x2g, z4.tla.t2e.xlc.x2h, z4.tla.t2e.x1d.x2a, z4.tla.t2e.x1d.x2b, z4.tla.t2e.x1d.x2c, z4.tla.t2e.xld.x2d, z4.tla.t2e.xld.x2e, z4.tla.t2e.xld.x2f, z4.tla.t2e.xld.x2g, z4.tla.t2e.xld.x2h, z4.tla.t2e.xle.x2a, z4.t1a.t2e.xle.x2b, z4.tla.t2e.xle.x2c, z4.tla.t2e.xle.x2d, z4.t1a.t2e.xle.x2e, z4.tla.t2e.xle.x2f, z4.tla.t2e.xle.x2g, z4.tla.t2e.xle.x2h, z4.tla.t2e.xlf.x2a, z4.tla.t2e.xlf.x2b, z4.tla.t2e.xlf.x2c, z4.tla.t2e.xlf.x2d, z4.tla.t2e.xlf.x2e, z4.tla.t2e.xlf.x2f, z4.tla.t2e.xlf.x2g, z4.t1a.t2e.x1f.x2h, z4.tla.t2e.xlg.x2a, z4.tla.t2e.xlg.x2b, z4.tla.t2e.xlg.x2c, z4.tla.t2e.xlg.x2d, z4.tla.t2e.xlg.x2e, z4.tla.t2e.xlg.x2f, z4.tla.t2e:xlg.x2g, z4.tla.t2e.xlg.x2h, z4.tla.t2e.xlh.x2a, z4.tla.t2e.xlh.x2b, z4.tla.t2e.xlh.x2c, z4.tla.t2e.xlh.x2d, z4.tla.t2e.xlh.x2e, z4.tla.t2e.xlh.x2f, z4.tla.t2e.xlh.x2g, z4.tla.t2e.xlh.x2h, z4.tlb.t2a.xla.x2a, z4.t1b.t2a.xla.x2b, z4.tlb.t2a.xla.x2c, z4.tlb.t2a.xla.x2d, z4.tlb.t2a.xla.x2e, z4.tlb.t2a.xla.x2f, z4.t1b.t2a.x1a.x2g, z4.tlb.t2a.xla.x2h, z4.tlb.t2a.xlb.x2a, z4.tlb.t2a.xlb.x2b, z4.tlb.t2a.xlb.x2c, z4:tlb.t2a.xlb.x2d, z4.tlb.t2a.xlb.x2e, z4.tlb.t2a.xlb.x2f, z4.tlb.t2a.xlb.x2g, z4.tlb.t2a.xlb.x2h, z4.tlb.t2a.xlc.x2a, z4.tlb.t2a.xlc.x2b, z4.tlb.t2a.xlc.x2c, z4.tlb.t2a.xlc.x2d, z4.tlb.t2a.xlc.x2e, z4.tlb.t2a.xlc.x2f, z4.tlb.t2a.xlc.x2g, z4.tlb.t2a.xlc.x2h, z4.tlb.t2a.x1d.x2a, z4.tlb.t2a.xld.x2b, z4.tlb.t2a.xld.x2c, z4.tlb.t2a.xld.x2d, z4.tlb.t2a.xld.x2e, z4.tlb.t2a.xld.x2f, z4.tlb.t2a.xld.x2g, z4.tlb.t2a.xld.x2h, z4.tlb.t2a.xle.x2a, z4.tlb.t2a.xle.x2b, z4.tlb.t2a.xle.x2c, z4.tlb.t2a.xle.x2d, z4.tlb.t2a.xle.x2e, z4.tlb.t2a.xle.x2f, z4.tlb.t2a.xle.x2g, z4.tlb.t2a.xle.x2h, z4.tlb.t2a.xlf.x2a, z4.tlb.t2a.xlf.x2b, z4.tlb.t2a.xlf.x2c, z4.tlb.t2a.x1f.x2d, z4.tlb.t2a.xlf.x2e, z4.tlb.t2a.xlf.x2f, z4.tlb.t2a.xlf.x2g, z4.tlb.t2a.xlf.x2h, z4.tlb.t2a.xlg.x2a, z4.tlb.t2a.xlg.x2b, z4.tlb.t2a.xlg.x2c, z4.t1b.t2a.xlg.x2d, z4.tlb.t2a.xlg.x2e, z4.tlb.t2a.xlg.x2f, z4.tlb.t2a.xlg.x2g, z4.tlb.t2a.xlg.x2h, z4.tlb.t2a.xlh.x2a, z4.tlb.t2a.xlh.x2b, z4.tlb.t2a.xlh.x2c, z4.tlb.t2a.xlh.x2d, z4.tlb.t2a.xlh.x2e, z4.tlb.t2a.xlh.x2f, z4.tlb.t2a.xlh.x2g, z4.tlb.t2a.x1h.x2h, z4.tlb.t2b.xla.x2a, z4.tlb.t2b.xla.x2b, z4.tlb.t2b.xla.x2c, z4.tlb.t2b.xla.x2d, z4.tlb.t2b.xla.x2e, z4.tlb.t2b.xla.x2f, z4.tlb.t2b.xla.x2g, z4.tlb.t2b.x1a.x2h, z4.tlb.t2b.xlb.x2a, z4.tlb.t2b.xlb.x2b, z4.tlb.t2b.xlb.x2c, z4.tlb.t2b.xlb.x2d, .10 z4.tlb.t2b.xlb.x2e, z4.tlb.t2b.xlb.x2f, z4.tlb.t2b.xlb.x2g, z4.tlb.t2b.xlb.x2h, z4.tlb.t2b.xlc.x2a, z4.tlb.t2b.xlc.x2b, z4.tlb.t2b.xlc.x2c, z4.tlb.t2b.xlc.x2d, z4.tlb.t2b.xlc.x2e, z4.tlb.t2b.xlc.x2f, z4.tlb.t2b.xlc.x2g, z4.tlb.t2b.xlc.x2h, z4.tlb.t2b.xld.x2a, z4.tlb.t2b.xld.x2b, z4.tlb.t2b.xld.x2c, z4.tlb.t2b.xld.x2d, z4.tlb.t2b.xld.x2e, z4.tlb.t2b.xld.x2f, z4.tlb.t2b.xld.x2g, z4.tlb.t2b.xld.x2h, z4.tlb.t2b.xle.x2a, z4.t1b.t2b.xle.x2b, z4.tlb.t2b.xle.x2c, z4.tlb.t2b.xle.x2d, z4.tlb.t2b.xle.x2e, z4.t1b.t2b.xle.x2f, z4.tlb.t2b.xle.x2g, z4.tlb.t2b.xle.x2h, z4.tlb.t2b.x1f.x2a, z4.tlb.t2b.xlf.x2b, z4.tlb.t2b.xlf.x2c, z4.tlb.t2b.xlf.x2d, z4.tlb.t2b.x1f.x2e, z4.t1b.t2b.xlf.x2f, z4.tlb.t2b.xlf.x2g, z4.tlb.t2b.xlf.x2h, z4.tlb.t2b.xlg.x2a, z4.tlb.t2b.xlg.x2b, z4.tlb.t2b.xlg.x2c, z4.tlb.t2b.xlg.x2d, z4.tlb.t2b.xlg.x2e, z4.tlb.t2b.xlg.x2f, z4.tlb.t2b.xlg.x2g, z4.tlb.t2b.x1g.x2h, z4.t1b.t2b.xlh.x2a, z4.tlb.t2b.xlh.x2b, z4.tlb.t2b.xlh.x2c, z4.tlb.t2b.xlh.x2d, z4.tlb.t2b.xlh.x2e, z4.tlb.t2b.xlh.x2f, z4.tlb.t2b.xlh.x2g, z4.tlb.t2b.xlh.x2h, z4.tlb.t2c.xla.x2a, z4.tlb.t2c.xla.x2b, z4.t1b.t2c.x1a.x2c, z4.tlb.t2c.xla.x2d, z4.tlb.t2c.xla.x2e, z4.tlb.t2c.xla.x2f, z4.tlb.t2c.xla.x2g, z4.tlb.t2c.xla.x2h, z4.tlb.t2c.xlb.x2a, z4.tlb.t2c.xlb.x2b, z4.tlb.t2c.xlb.x2c, z4.tlb.t2c.xlb.x2d, z4.tlb.t2c.xlb.x2e, z4.tlb.t2c.xlb.x2f, z4.tlb.t2c.xlb.x2g, z4.tlb.t2c.xlb.x2h, z4.tlb.t2c.xlc.x2a, z4.tlb.t2c.xlc.x2b, z4.tlb.t2c.xlc.x2c, z4.tlb.t2c.xlc.x2d, z4.tlb.t2c.xlc.x2e, z4.t1b.t2c.x1c.x2f, z4.tlb.t2c.xlc.x2g, z4.tlb.t2c.xlc.x2h, z4.tlb.t2c.xld.x2a, z4.t1b.t2c.xld.x2b, z4.t1b.t2c.xld.x2c, z4.tlb.t2c.xld.x2d, z4.tlb.t2c.xld.x2e, z4.tlb.t2c.xld.x2f, z4.tlb.t2c.xld.x2g, z4.tlb.t2c.x1d.x2h, z4.t1b.t2c.x1e.x2a, z4.t1b.t2c.x1e.x2b, z4.tlb.t2c.xle.x2c, z4.tlb.t2c.xle.x2d, z4.tlb.t2c.xle.x2e, z4.tlb.t2c.xle.x2f, z4.tlb.t2c.xle.x2g, z4.tlb.t2c.xle.x2h, z4.tlb.t2c.xlf.x2a, z4.tlb.t2c.xlf.x2b, z4.tlb.t2c.xlf.x2c, z4.tlb.t2c.xlf.x2d, z4.tlb.t2c.xlf.x2e, z4.tlb.t2c.xlf.x2f, z4.tlb.t2c.xlf.x2g, z4.tlb.t2c.xlf.x2h, z4.tlb.t2c.xlg.x2a, z4.tlb.t2c.xlg.x2b, z4.tlb.t2c.x1g.x2c, z4.tlb.t2c.xlg.x2d, z4.tlb.t2c.xlg.x2e, z4.tlb.t2c.xlg.x2f, z4.tlb.t2c.xlg.x2g, z4.tlb.t2c.xlg.x2h, z4.tlb.t2c.xlh.x2a, z4.tlb.t2c.xlh.x2b, z4.tlb.t2c.xlh.x2c, z4.tlb.t2c.x1h.x2d, z4.tlb.t2c.xlh.x2e, z4.t1b.t2c.x1h.x2f, z4.tlb.t2c.xlh.x2g, z4.t1b.t2c.x1h.x2h, z4.tlb.t2d.xla.x2a, z4.tlb.t2d.x1a.x2b, z4.tlb.t2d.xla.x2c, z4_t1b.t2d.x1a.x2d, z4.tlb_t2d.x1a.x2e, z4.t1b.t2d.x1a.x2f, z4.tlb.t2d.x1a.x2g, z4.tlb.t2d.xla.x2h, z4.tlb.t2d.xlb.x2a, z4.tlb.t2d.xlb.x2b, z4.tlb.t2d.xlb.x2c, z4.tlb.t2d.xlb.x2d, z4.t1b.t2d.xlb.x2e, z4.t1b.t2d.xlb.x2f, z4.tlb.t2d.xlb.x2g, z4.tlb.t2d.xlb.x2h, z4.tlb.t2d.xlc.x2a, z4.tlb.t2d.x1c.x2b, z4.tlb.t2d.xlc.x2c, z4.tlb.t2d.xlc.x2d, z4.tlb.t2d.xlc.x2e, z4.tlb.t2d.xlc.x2f, z4.tlb.t2d.xlc.x2g, z4.tlb.t2d.xlc.x2h, z4.tlb.t2d.xld.x2a, z4.tlb.t2d.xld.x2b, z4.tlb.t2d.xld.x2c, z4.tlb.t2d.x1d.x2d, z4.t1b.t2d.xld.x2e, z4.tlb.t2d.xld.x2f, z4.tlb.t2d.xld.x2g, z4.tlb.t2d.xld.x2h, z4.tlb.t2d.xle.x2a, z4.tlb.t2d.x1e.x2b, z4.tlb.t2d.xle.x2c, z4.tlb.t2d.xle.x2d, z4.tlb.t2d.xle.x2e,.z4.t1b.t2d.x1e.x2f, z4.tlb.t2d.xle.x2g, z4.tlb.t2d.xle.x2h, z4.tlb.t2d.xlf.x2a, z4.tlb.t2d.xlf.x2b, z4.tlb.t2d.xlf.x2c, z4.tlb.t2d.xlf.x2d, z4.tlb.t2d.xlf.x2e, z4.tlb.t2d.xlf.x2f, z4.tlb.t2d.xlf.x2g, z4.tlb.t2d.xlf.x2h, z4.tlb.t2d.xlg.x2a, z4.tlb.t2d.xlg.x2b, z4.t1b.t2d.xlg.x2c, z4.tlb.t2d.xlg.x2d, z4.tlb.t2d.xlg.x2e, z4.tlb.t2d.xlg.x2f, z4.tlb.t2d.xlg.x2g, z4.tlb.t2d.xlg.x2h, z4.tlb.t2d.xlh.x2a, z4.tlb.t2d.xlh.x2b, z4.tlb.t2d.xlh.x2c, z4.tlb.t2d.xlh.x2d, z4.tlb.t2d.xlh.x2e, z4.tlb.t2d.xlh.x2f, z4.tlb.t2d.xlh.x2g, z4.tlb.t2d.xlh.x2h, z4.tlb.t2e.xla.x2a, z4.tlb.t2e.xla.x2b, z4.tlb.t2e.xla.x2c, z4.tlb.t2e.xla.x2d, z4.tlb.t2e.xla.x2e, z4.tlb.t2e.xla.x2f, z4.tlb.t2e.xla.x2g, z4.tlb.t2e.xla.x2h, z4.tlb.t2e.xlb.x2a, z4.tlb.t2e.xlb.x2b, z4.tlb.t2e.xlb.x2c, z4.tlb.t2e.xlb.x2d, z4.tlb.t2e.xlb.x2e, z4.tlb.t2e.xlb.x2f, z4.tlb.t2e.xlb.x2g, z4.tlb.t2e.xlb.x2h, z4.tlb.t2e.xlc.x2a, z4.tlb.t2e.xlc.x2b, z4.tlb.t2e.xlc.x2c, z4.tlb.t2e.xlc.x2d, z4.tlb.t2e.xlc.x2e, z4.tlb.t2e.xlc.x2f, z4.tlb.t2e.xlc.x2g, z4.tlb.t2e.xlc.x2h, z4.tlb.t2e.xld.x2a, z4.tlb.t2e.xld.x2b, z4.tlb.t2e.xld.x2c, z4.tlb.t2e.xld.x2d, z4.tlb.t2e.xld.x2e, z4.tlb.t2e.xld.x2f, z4.tlb.t2e.xld.x2g, z4.tlb.t2e.xld.x2h, z4.tlb.t2e.xle.x2a, z4.tlb.t2e.xle.x2b, z4.tlb.t2e.xle.x2c, z4.tlb.t2e.xle.x2d, z4.tlb.t2e.xle.x2e, z4.tlb.t2e.xle.x2f, z4.tlb.t2e.xle.x2g, z4.t1b.t2e.x1e.x2h, z4.tlb.t2e.xlf.x2a, z4.tlb.t2e.xlf.x2b, z4.tlb.t2e.xlf.x2c, z4.t1b.t2e.xlf.x2d, z4.tlb.t2e.xlf.x2e, z4.tlb.t2e.xlf.x2f, z4.tlb.t2e.xlf.x2g, z4.tlb.t2e.x1f.x2h, z4.tlb.t2e.xlg.x2a, z4.tlb.t2e.xlg.x2b, z4.tlb.t2e.x1g.x2c, z4.tlb.t2e.xlg.x2d, z4.tlb.t2e.xlg.x2e, z4.tlb.t2e.xlg.x2f, z4.tlb.t2e.xlg.x2g, z4.tlb.t2e.xlg.x2h, z4.tlb.t2e.xlh.x2a, z4.tlb.t2e.xlh.x2b, z4.tlb.t2e.xlh.x2c, z4.tlb.t2e.xlh.x2d, z4.tlb.t2e.xlh.x2e, z4.t1b.t2e.xlh.x2f, z4.tlb.t2e.xlh.x2g, z4.tlb.t2e.xlh.x2h, z4.tlc.t2a.xla.x2a, z4.tlc.t2a.xla.x2b, z4.tlc.t2a.xla.x2c, z4.tlc.t2a.xla.x2d, z4.tlc.t2a.xla.x2e, z4.tlc.t2a.xla.x2f, z4.tlc.t2a.xla.x2g, z4.tlc.t2a.xla.x2h, z4.tlc.t2a.xlb.x2a, z4.tlc.t2a.xlb.x2b, z4.tlc.t2a.xlb.x2c, z4.tlc.t2a.xlb.x2d, z4.tlc.t2a.xlb.x2e, z4.tlc.t2a.xlb.x2f, z4.tlc.t2a.xlb.x2g, z4.tlc.t2a.xlb.x2h, z4.tlc.t2a.xlc.x2a, z4.tlc.t2a.xlc.x2b, z4.tlc.t2a.xlc.x2c, z4.tlc.t2a.xlc.x2d, z4.t1c.t2a.xlc.x2e, z4.tlc.t2a.xlc.x2f, z4.tlc.t2a.xlc.x2g, z4.tlc.t2a.xlc.x2h, z4.tlc.t2a.xld.x2a, z4.tlc.t2a.xld.x2b, z4.tlc.t2a.xld.x2c, z4.tlc.t2a.xld.x2d, z4.tlc.t2a.xld.x2e, z4.tlc.t2a.xld.x2f, z4.tlc.t2a.xld.x2g, z4.tlc.t2a.xld.x2h, z4.tlc.t2a.xle.x2a, z4.tlc.t2a.xle.x2b, z4.tlc.t2a.xle.x2c, z4.tlc.t2a.xle.x2d, z4.tlc.t2a.xle.x2e, z4.tlc.t2a.xle.x2f, z4.tlc.t2a.xle.x2g, z4.tlc.t2a_xle.x2h, z4.tlc.t2a.xlf.x2a, z4.t1c_t2a.xlf.x2b, z4.tlc.t2a.xlf.x2c, z4.tlc.t2a.xlf.x2d, z4.t1c.t2a_x1f.x2e, z4.tlc.t2a.xlf.x2f, z4.tlc.t2a.xlf.x2g, z4.tlc.t2a.xlf.x2h, z4.tlc.t2a.xlg.x2a, z4.tlc.t2a.xlg.x2b, z4.tlc.t2a.xlg.x2c, z4.tlc.t2a.xlg.x2d, z4.tlc.t2a.xlg.x2e, z4.tlc.t2a.xlg.x2f, z4.tlc.t2a.xlg.x2g, z4.tlc.t2a.xlg.x2h, z4.tlc.t2a.xlh.x2a, z4.tlc.t2a.xlh.x2b, z4.tlc.t2a.xlh.x2c, z4.tlc.t2a.xlh.x2d, z4.tlc.t2a.xlh.x2e, z4.tlc.t2a.xlh.x2f, z4.tlc.t2a.xlh.x2g, z4.tlc.t2a.xlh.x2h, z4.tlc.t2b.xla.x2a, z4.tlc.t2b.xla.x2b, z4.tlc.t2b.xla.x2c, z4.tlc.t2b.xla.x2d, z4.tlc.t2b.xla.x2e, z4.tlc.t2b.xla.x2f, z4.tlc.t2b.xla.x2g, z4.tlc.t2b.xla.x2h, z4.tlc.t2b.xlb.x2a, z4.tlc.t2b.xlb.x2b, z4.tlc.t2b.xlb.x2c, z4.tlc.t2b.xlb.x2d, z4.tlc.t2b.xlb.x2e, z4.tlc.t2b.xlb.x2f, z4.tlc.t2b.xlb.x2g, z4.tlc.t2b.xlb.x2h, z4.tlc.t2b.xlc.x2a, z4.tlc.t2b.xlc.x2b, z4.tlc.t2b.xlc.x2c, z4.tlc.t2b.xlc.x2d, z4.tlc.t2b.xlc.x2e, z4.tlc.t2b.xlc.x2f, z4.tlc.t2b.xlc.x2g, z4.t1c.t2b.xlc.x2h, z4.tlc.t2b.xld.x2a, z4.tlc.t2b.xld.x2b, z4.tlc.t2b.xld.x2c, z4.tlc.t2b.xld.x2d, z4.tlc.t2b.xld.x2e, z4.tlc.t2b.xld.x2f, z4.tlc.t2b.xld.x2g, z4.tlc.t2b.xld.x2h, z4.tlc.t2b.xle.x2a, z4.tlc.t2b.xle.x2b, z4.tlc.t2b.xle.x2c, z4.tlc.t2b.xle.x2d, z4.tlc.t2b.xle.x2e, z4.t1c.t2b.xle.x2f, z4.tlc.t2b.xle.x2g, z4.tlc.t2b.xle.x2h, z4.tlc.t2b.xlf.x2a, z4.tlc.t2b.xlf.x2b, z4.tlc.t2b.xlf.x2c, z4.tlc.t2b.xlf.x2d, z4.tlc.t2b.xlf.x2e, z4.tlc.t2b.xlf.x2f, z4.tlc.t2b.xlf.x2g, z4.tlc.t2b.xlf.x2h, z4.tlc.t2b.xlg.x2a, z4.tlc.t2b.xlg.x2b, z4.tlc.t2b.xlg.x2c, z4.tlc.t2b.xlg.x2d, z4.tlc.t2b.xlg.x2e, z4.tlc.t2b.xlg.x2f, z4.tlc.t2b.xlg.x2g, z4.tlc.t2b.xlg.x2h, z4.tlc.t2b.xlh.x2a, z4.tlc.t2b.xlh.x2b, z4.tlc.t2b.ic1h.x2c, z4.tlc.t2b.xlh.x2d, z4.tlc.t2b.xlh.x2e, z4.tlc.t2b.xlh.x2f, z4.tlc.t2b.xlh.x2g, z4.tlc.t2b.x1h.x2h, z4.tlc.t2c.xla.x2a, z4.tlc.t2c.xla.x2b, z4.tlc.t2c.xla.x2c, z4.tlc.t2c.xla.x2d, z4.tlc.t2c.xla.x2e, z4.tlc.t2c.xla.x2f, z4.tlc.t2c.xla.x2g, z4.tlc.t2c.x1a.x2h, z4.tlc.t2c.xlb.x2a, z4.tlc.t2c.xlb.x2b, z4.tlc.t2c.x1b.x2c, z4.tlc.t2c.xlb.x2d, z4.tlc.t2c.x1b.x2e, z4.tlc.t2c.xlb.x2f, z4.tlc.t2c.xlb.x2g, z4.tlc.t2c.xlb.x2h, z4.tlc.t2c.xlc.x2a, z4.tlc.t2c.xlc.x2b, z4.tlc.t2c.xlc.x2c, z4.tlc.t2c.xlc.x2d, z4.t1c_t2c.xlc.x2e, z4.tlc.t2c.xlc.x2f, z4.tlc.t2c.xlc.x2g, z4.tlc.t2c.xlc.x2h, z4.tlc.t2c.xld.x2a, z4.tlc.t2c.xld.x2b, z4.tlc.t2c.xld.x2c, z4.tlc.t2c.xld.x2d, z4.tlc.t2c.xld.x2e, z4.tlc.t2c.xld.x2f, z4.tlc.t2c.xld.x2g, z4.tlc.t2c.xld.x2h, z4.tlc.t2c.xle.x2a, z4.tlc.t2c.xle.x2b, z4.tlc.t2c.xle.x2c, z4.tlc.t2c.xle.x2d, z4.tlc.t2c.xle.x2e, z4.tlc.t2c.xle.x2f, z4.tlc.t2c.xle.x2g, z4.tlc.t2c.xle.x2h, z4.tlc.t2c.xlf.x2a,.z4.tlc.t2c.xlf.x2b, z4.tlc.t2c.xlf.x2c, z4.tlc.t2c.xlf.x2d, z4.tlc.t2c.xlf.x2e, z4.tlc.t2c.xlf.x2f, z4.tlc.t2c.xlf.x2g, z4.tlc.t2c.xlf.x2h, z4.tlc.t2c.xlg.x2a, z4.tlc.t2c.xlg.x2b, z4.tlc.t2c.xlg.x2c, z4.tlc.t2c.xlg.x2d, z4.t1c.t2c.x1g.x2e, z4.tlc.t2c.xlg.x2f, z4.t1c.t2c.xlg.x2g, z4.tlc.t2c.xlg.x2h, z4.tlc.t2c.xlh.x2a, z4.tlc.t2c.xlh.x2b, z4.tlc.t2c.xlh.x2c, z4.tlc.t2c.xlh.x2d, z4.tlc.t2c.xlh.x2e, z4.tlc.t2c.xlh.x2f, z4.tlc.t2c.xlh.x2g, z4.tlc.t2c.xlh.x2h, z4.tlc.t2d.xla.x2a, z4.tlc.t2d.xla.x2b, z4.tlc.t2d.xla.x2c, z4.tlc.t2d.xla.x2d, z4.tlc.t2d.xla.x2e; z4.tlc.t2d.xla.x2f, z4.tlc.t2d.xla.x2g, z4.tlc.t2d.xla.x2h, z4.tlc.t2d.xlb.x2a, z4.tlc.t2d.xlb.x2b, z4.tlc.t2d.xlb.x2c, z4.t1c.t2d.x1b.x2d, z4.tlc.t2d.xlb.x2e, z4.tlc.t2d.xlb.x2f, z4.tlc.t2d.xlb.x2g, z4.tlc.t2d.xlb.x2h, z4.tlc.t2d.xlc.x2a, z4.tlc.t2d.xlc.x2b, z4.tlc.t2d.xlc.x2c, z4.tlc.t2d.xlc.x2d, z4.tlc.t2d.xlc.x2e, z4.tlc.t2d.xlc.x2f, z4.tlc.t2d.xlc.x2g, z4.tlc.t2d.xlc.x2h, z4.tlc.t2d.xld.x2a, z4.tlc.t2d.xld.x2b, z4.tlc.t2d.xld.x2c, z4.tlc.t2d.xld.x2d, z4.tlc.t2d.xld.x2e, z4.tlc.t2d.xld.x2f, z4_t1c.t2d.xld.x2g, z4.tlc.t2d.xld.x2h, z4.tlc.t2d.xle.x2a, z4.tlc.t2d.xle.x2b, z4.tlc.t2d.xle.x2c, z4.tlc.t2d.xle.x2d, z4.tlc.t2d.xle.x2e, z4.tlc.t2d.xle.x2f, z4.tlc.t2d.xle.x2g, z4.tlc.t2d.xle.x2h, z4.tlc.t2d.xlf.x2a, z4.tlc.t2d.xlf.x2b, z4.tlc.t2d.xlf.x2c, z4.tlc.t2d.xlf.x2d, z4.tlc.t2d.xlf.x2e, z4.tlc.t2d.xlf.x2f, z4.tlc.t2d.xlf.x2g, z4.t1c.t2d.xlf.x2h, z4.tlc.t2d.xlg.x2a, z4.tlc.t2d.xlg.x2b, z4.tlc.t2d.xlg.x2c, z4.tlc.t2d.xlg.x2d, z4.tlc.t2d.x1g.x2e, z4.tlc.t2d.xlg.x2f, z4.tlc.t2d.xlg.x2g, z4.tlc.t2d.xlg.x2h, z4.tlc.t2d.xlh.x2a, z4.tlc.t2d.xlh.x2b, z4.tlc.t2d.xlh.x2c, z4.tlc.t2d.xlh.x2d, z4.tlc.t2d.xlh.x2e, z4.tlc.t2d.xlh.x2f, z4.tlc.t2d.xlh.x2g, z4.tlc.t2d.xlh.x2h, z4.tlc.t2e.xla.x2a, z4.tlc.t2e.xla.x2b, z4.tlc.t2e.xla.x2c, z4.tlc.t2e.x1a.x2d, z4_tlc.t2e.xla.x2e, z4.tlc.t2e.xla.x2f, z4.tlc.t2e.xla.x2g, z4.t1c.t2e.x1a.x2h, z4.tlc.t2e.xlb.x2a, z4.tlc.t2e.xlb.x2b, z4.tlc.t2e.xlb.x2c, z4.tlc.t2e.xlb.x2d, z4.tlc.t2e.xlb.x2e, z4.tlc.t2e.xlb.x2f, z4.tlc.t2e.xlb.x2g, z4.tlc.t2e.xlb.x2h, z4.tlc.t2e.xlc.x2a, z4.tlc.t2e.xlc.x2b, z4.tlc.t2e.xlc.x2c, z4.tlc.t2e.xlc.x2d, z4.tlc.t2e.x1c.x2e, z4.tlc.t2e.xlc.x2f, z4.tlc.t2e.xlc.x2g, z4.tlc.t2e.xlc.x2h, z4.tlc.t2e.xld.x2a, z4.tlc.t2e.xld.x2b, z4.tlc.t2e.xld.x2c, z4.t1c.t2e.xld.x2d, z4.t1c.t2e.xld.x2e, z4.tlc.t2e.xld.x2f, z4.tlc.t2e.xld.x2g, z4.tlc.t2e.xld.x2h, z4.tlc.t2e.xle.x2a, z4.tlc.t2e.xle.x2b, z4.tlc.t2e.xle.x2c, z4.tlc.t2e.x1e.x2d, z4.tlc.t2e.xle.x2e, z4.tlc.t2e.xle.x2f, z4.tlc.t2e.xle.x2g, z4.tlc.t2e.xle.x2h, z4.tlc.t2e.xlf.x2a, z4.tlc.t2e.xlf.x2b, z4.tlc.t2e.xlf.x2c, z4.t1c.t2e.xlf.x2d, z4.tlc.t2e.xlf.x2e, z4.tlc.t2e.xlf.x2f, z4.tlc.t2e.xlf.x2g, z4.tlc.t2e.xlf.x2h, z4.tlc.t2e.xlg.x2a, z4.tlc.t2e.xlg.x2b, z4.tlc.t2e.xlg.x2c, z4.tlc.t2e.xlg.x2d, z4.tlc.t2e.xlg.x2e, z4.tlc.t2e.xlg.x2f, z4.tlc.t2e.xlg.x2g, z4.tlc.t2e.xlg.x2h, z4.tlc.t2e.xlh.x2a, z4.t1c.t2e.x1h.x2b, z4.tlc.t2e.xlh.x2c, z4.tlc.t2e.xlh.x2d, z4.tlc.t2e.xlh.x2e, z4.tlc.t2e.xlh.x2f, z4.tlc.t2e.xlh.x2g, z4.tlc.t2e.xlh.x2h, z4.tld.t2a.xla.x2a, z4.tld.t2a.xla.x2b, z4.tld.t2a.xla.x2c, z4.tld.t2a.xla.x2d, z4.tld.t2a.xla.x2e, z4.tld.t2a.xla.x2f, z4.tld.t2a.xla.x2g, z4.tld.t2a.xla.x2h, -z4.tld.t2a.xlb.x2a, z4.t1d.t2a.xlb.x2b, z4.tld.t2a.xlb.x2c, z4.tld.t2a.xlb.x2d, z4.tld.t2a.xlb.x2e, z4.tld.t2a.xlb.x2f, z4.tld.t2a.xlb.x2g, z4.tld.t2a.xlb.x2h, z4.tld.t2a.xlc.x2a, z4.tld.t2a.xlc.x2b, z4.tld.t2a.xlc.x2c, z4.tld.t2a.xlc.x2d, z4.tld.t2a.xlc.x2e, z4.tld.t2a.xlc.x2f, z4.tld.t2a.xlc.x2g, z4.tld.t2a.xlc.x2h, z4.tld.t2a.xld.x2a, z4.tld.t2a.xld.x2b, z4.tld.t2a.xld.x2c, z4.tld.t2a.xld.x2d, z4.tld.t2a.xld.x2e, z4.tld.t2a.xld.x2f, z4.tld.t2a.xld.x2g, z4.tld.t2a.x1d.x2h, z4.tld.t2a.xle.x2a, z4.tld.t2a.xle.x2b, z4.tld.t2a.xle.x2c, z4.tld.t2a.xle.x2d, z4.tld.t2a.xle.x2e, z4.tld.t2a.xle.x2f, z4.tld.t2a.xle.x2g, z4.tld.t2a.xle.x2h, z4.tld.t2a.xlf.x2a, z4.tld.t2a.xlf.x2b, z4.tld.t2a.xlf.x2c, z4.tld.t2a.xlf.x2d, z4.tld.t2a.xlf.x2e, z4.tld.t2a.xlf.x2f, z4.tld.t2a.xlf.x2g, z4.tld.t2a.xlf.x2h, z4.tld.t2a.xlg.x2a, z4.tld.t2a.xlg.x2b, z4.tld.t2a.xlg.x2c, z4.tld.t2a.xlg.x2d, z4.tld.t2a.xlg.x2e, z4.tld.t2a.xlg.x2f, z4.t1d.t2a.xlg.x2g, z4.tld.t2a.xlg.x2h, z4.tld.t2a.xlh.x2a, z4.tld.t2a.xlh.x2b, z4.tld.t2a.xlh.x2c, z4.tld.t2a.xlh.x2d, z4.tld.t2a.xlh.x2e, z4.tld.t2a.xlh.x2f, z4.tld.t2a.xlh.x2g, z4.tld.t2a.xlh.x2h, z4.tld.t2b.xla.x2a, z4.tld.t2b.xla.x2b, z4.tld.t2b.xla.x2c, z4.tld.t2b.xla.x2d, z4.tld.t2b.xla.x2e, z4.tld.t2b.xla.x2f, z4.tld.t2b.xla.x2g, z4.tld.t2b.xla.x2h, z4.tld.t2b.xlb.x2a, z4.tld.t2b.xlb.x2b, z4.tld.t2b.xlb.x2c, z4.tld.t2b.xlb.x2d, z4.tld.t2b.xlb.x2e, z4.tld.t2b.xlb.x2f, z4.tld.t2b.xlb.x2g, z4.tld.t2b.xlb.x2h, z4.tld.t2b.xlc.x2a, z4.tld.t2b.xlc.x2b, z4.tld.t2b.xlc.x2c, z4.tld.t2b.xlc.x2d, z4.tld.t2b.xlc.x2e, z4.tld.t2b.xlc.x2f, z4.tld.t2b.xlc.x2g, z4.tld.t2b.xlc.x2h, z4.tld.t2b.xld.x2a, z4.tld.t2b.xld.x2b, z4.tld.t2b.xld.x2c, z4.tld.t2b.xld.x2d, z4.tld.t2b.xld.x2e, z4.tld.t2b.xld.x2f, z4.tld.t2b.xld.x2g, z4.tld.t2b.xld.x2h, z4.tld.t2b.xle.x2a, z4.tld.t2b.xle.x2b, z4.tld.t2b.xle.x2c, z4.t1d.t2b.x1e.x2d, z4.tld.t2b.xle.x2e, z4.tld.t2b.xle.x2f, z4.tld.t2b.xle.x2g, z4.tld.t2b.xle.x2h, z4.tld.t2b.xlf.x2a, z4.tld.t2b.xlf.x2b, z4.tld.t2b.xlf.x2c, z4.tld.t2b.x1f.x2d, z4.tld.t2b.xlf.x2e, z4.tld.t2b.xlf.x2f, z4.tld.t2b.xlf.x2g, z4.tld.t2b.xlf.x2h, z4.tld.t2b.xlg.x2a, z4.tld.t2b.xlg.x2b, z4.tld.t2b.xlg.x2c, z4.tld.t2b.xlg.x2d, z4.tld.t2b.xlg.x2e, z4.tld.t2b.xlg.x2f, z4.tld.t2b.xlg.x2g, z4.tld.t2b.x1g.x2h, z4.tld.t2b.xlh.x2a, z4.tld.t2b.xlh.x2b, z4.tld.t2b.xlh.x2c, z4.tld.t2b.xlh.x2d, z4.tld.t2b.xlh.x2e, z4.tld.t2b.xlh.x2f, z4.tld.t2b.xlh.x2g, z4.tld.t2b.xlh.x2h, z4.tld.t2c.xla.x2a, z4.tld.t2c.xla.x2b, z4.tld.t2c.xla.x2c, z4.tld.t2c.xla.x2d, z4.tid.t2c.xla.x2e, z4.tld.t2c.xla.x2f, z4.tld.t2c.xla.x2g, z4.tld.t2c.xla.x2h, z4.tld.t2c.xlb.x2a, z4.tld.t2c.xlb.x2b, z4.tld:t2c.xlb.x2c, z4.tld.t2c.xlb.x2d, z4.tld.t2c.xlb.x2e, z4.tld.t2c.xlb.x2f, z4.tld.t2c.xlb.x2g, z4.t1d.t2c.xlb.x2h, z4.tld.t2c.xlc.x2a, z4.tld.t2c.xlc.x2b, z4.tld.t2c_xlc.x2c, z4.tld.t2c.xlc.x2d, z4.tld.t2c.xlc.x2e, z4.tld.t2c.xlc.x2f, z4.tld.t2c.xlc.x2g, z4.tld.t2c.xlc.x2h, z4.tld.t2c.x1d.x2a, z4.tld.t2c.xld.x2b, z4.tld.t2c.xld.x2c, z4.tld.t2c.xld.x2d, z4.tld.t2c.xld.x2e, z4.tld.t2c.xld.x2f, z4.tld.t2c.xld.x2g, z4.tld.t2c.xld.x2h, z4.tld.t2c.xle.x2a, z4.tld.t2c.xle.x2b, z4.tld.t2c.xle.x2c, z4.tld.t2c.xle.x2d, z4.tld.t2c.xle.x2e, z4.tld.t2c.xle.x2f, z4.tld.t2c.xle.x2g, z4.tld.t2c.xle.x2h, z4.tld.t2c.xlf.x2a, z4.tld.t2c.xlf.x2b, z4.tld.t2c.xlf.x2c, z4.tld.t2c.xlf.x2d, z4.t1d.t2c.xlf.x2e, z4.tld.t2c.xlf.x2f, z4.tld.t2c.xlf.x2g, z4.tld.t2c.xlf.x2h, z4.tld.t2c.xlg.x2a, z4.tld.t2c.xlg.x2b, z4.tld.t2c.xlg.x2c, z4.tld.t2c.xlg.x2d, z4.tld.t2c.xlg.x2e, z4.t1d.t2c,x1g.x2f, z4.tld.t2c.xlg.x2g, z4.t1d.t2c.xlg.x2h, z4.tld.t2c.xlh.x2a, z4.tld.t2c.xlh.x2b, z4.tld.t2c.xlh.x2c, z4.t1d.t2c.xlh.x2d, z4.tld.t2c.xlh.x2e, z4.tld.t2c.xlh.x2f, z4.tld.t2c.xlh.x2g, z4.tld.t2c.xlh.x2h, z4.tld.t2d.xla.x2a, z4.tld.t2d.xla.x2b, z4.tld.t2d.xla.x2c, z4.tld.t2d.xla.x2d, z4.tld.t2d.xla.x2e, z4.tld.t2d.xla.x2f, z4.tld.t2d.xla.x2g, z4.tld.t2d.xla.x2h, z4.tld.t2d.xlb.x2a, z4.tld.t2d.xlb.x2b, z4.tld.t2d.xlb.x2c, z4.tld.t2d.xlb.x2d, z4.t1d.t2d.xlb.x2e, z4.tld.t2d.xlb.x2f, z4.tld.t2d.xlb.x2g, z4.tld.t2d.xlb.x2h, z4.tld.t2d.xlc.x2a, z4.tld.t2d.xlc.x2b, z4.tld.t2d.xlc.x2c, z4.tld.t2d.xlc.x2d, z4.tld.t2d.xlc.x2e, z4.tld.t2d.xlc.x2f, z4.tld.t2d.xlc.x2g, z4.tld.t2d.xlc.x2h, z4.tld.t2d.xld.x2a, z4.tld.t2d.x1d.x2b, z4.tld.t2d.xld.x2c, z4.tld.t2d.xld.x2d, z4.t1d.t2d.xld.x2e, z4.tld.t2d.xld.x2f, z4.tld.t2d.x1d.x2g, z4.tld.t2d.xld.x2h, z4.tld.t2d.xle.x2a, z4.tld.t2d.x1e.x2b, z4.tld.t2d.xle.x2c, z4.tld.t2d.xle.x2d, z4.tld.t2d.xle.x2e, z4.tld.t2d.xle.x2f, z4.tld.t2d.xle.x2g, z4.tld.t2d.xle.x2h, z4.tld.t2d.xlf.x2a, z4.tld.t2d.xlf.x2b, z4.tld.t2d.xlf.x2c, z4.tld.t2d.xlf.x2d, z4.tld.t2d.xlf.x2e, z4.tld.t2d.xlf.x2f, z4.tld.t2d.xlf.x2g, z4.tld.t2d.xlf.x2h, z4.tld.t2d.xlg.x2a, z4.tld.t2d.xlg.x2b, z4.tld.t2d.xlg.x2c, z4.tld.t2d.xlg.x2d, z4.tld.t2d.xlg.x2e, z4.tld.t2d.xlg.x2f,.z4.t1d.t2d.xlg.x2g, z4.tld.t2d.xlg.x2h, z4.t1d.t2d.xlh.x2a, z4.tld.t2d.xlh.x2b, z4.tld.t2d.xlh.x2c, z4.tld.t2d.xlh.x2d, z4.tld.t2d.xlh.x2e, z4.tld.t2d.xlh.x2f, z4.tld.t2d.xlh.x2g, z4.tld.t2d.xlh.x2h, z4.tld.t2e.xla.x2a, z4.tld.t2e.xla.x2b, z4.tld.t2e.xla.x2c, z4.tld.t2e.xla.x2d, z4.tld.t2e.xla.x2e, z4.tld.t2e.xla.x2f, z4.tld.t2e.xla.x2g, z4.tld.t2e.xla.x2h, z4.tld.t2e.xlb.x2a, z4.t1d.t2e.xlb.x2b, z4.tld.t2e.xlb.x2c, z4.tld.t2e.xlb.x2d, z4.tld.t2e.xlb.x2e, z4.tld.t2e.xlb.x2f, z4.tld.t2e.xlb.x2g, z4.tld.t2e.xlb.x2h, z4.tld.t2e.xlc.x2a, z4.tld.t2e.xlc.x2b, z4.tld.t2e.xlc.x2c, z4.tld.t2e.xlc.x2d, z4.tld.t2e.xlc.x2e, z4.tld.t2e.xlc.x2f, z4.tld.t2e.xlc.x2g, z4.tld.t2e.xlc.x2h, z4.tld.t2e.xld.x2a, z4.tld.t2e.xld.x2b, z4.tld.t2e.xld.x2c, z4.tld.t2e.x1d.x2d, z4.tld.t2e.x1d.x2e; z4.tld.t2e.xld.x2f, z4.tld.t2e.xld.x2g, z4.tld.t2e.xld.x2h, z4.tld.t2e.xle.x2a, z4.tld.t2e.xle.x2b, z4.tld.t2e.xle.x2c, z4.tld.t2e.xle.x2d, z4.t1d.t2e.xle.x2e, z4.tld.t2e.xle.x2f, z4.tld.t2e.xle.x2g, z4.tld.t2e.xle.x2h, z4.tld.t2e.xlf.x2a, z4.tld.t2e.xlf.x2b, z4.tld.t2e.xlf.x2c, z4.tld.t2e.xlf.x2d, z4.tld.t2e.xlf.x2e, z4.tld.t2e.xlf.x2f, z4.tld.t2e.xlf.x2g, z4.tld.t2e.xlf.x2h, z4.tld.t2e.xlg.x2a, z4.tld.t2e.xlg.x2b, z4.tld.t2e.x1g.x2c, z4.tld.t2e_xlg.x2d, z4.tld.t2e.xlg.x2e, z4.tld.t2e.xlg.x2f, z4.tld.t2e.xlg.x2g, z4.tld.t2e.xlg_x2h, z4.tld.t2e.xlh.x2a, z4.tld.t2e.xlh.x2b, z4.tld.t2e.xlh.x2c, z4.tld.t2e.xlh.x2d, z4.t1d.t2e.xlh.x2e, z4.tld.t2e.xlh.x2f, z4.tld.t2e.x1h.x2g, z4.tld.t2e.xlh.x2h, z4.tle.t2a.xla.x2a, z4.tle.t2a.xla.x2b, z4.tle.t2a.xla.x2c, z4.tle.t2a.xla.x2d, z4.tle.t2a.xla.x2e, z4.tle:t2a.xla.x2f, z4.tle.t2a.xla.x2g, z4.tle.t2a.xla.x2h, z4.tle.t2a.xlb.x2a, z4.tle.t2a.xlb.x2b, z4.tle.t2a.xlb.x2c, z4.tle.t2a.xlb.x2d, z4.tle.t2a.xlb.x2e, z4.tle.t2a.xlb.x2f, z4.tle.t2a.xlb.x2g, z4.tle.t2a.xlb.x2h, z4.tle.t2a.xlc.x2a, z4.tle.t2a.xlc.x2b, z4.tle.t2a.xlc.x2c, z4.tle.t2a.xlc.x2d, z4.tle.t2a.xlc.x2e, z4.tle.t2a.xlc.x2f, z4.tle.t2a.xlc.x2g, z4.tle.t2a.xlc.x2h, z4.tle.t2a.xld.x2a, z4.tle.t2a.xld.x2b, z4.tle.t2a.xld.x2c, z4.tle.t2a.xld.x2d, z4.tle.t2a.x1d.x2e, z4.tle.t2a.xld.x2f, z4.tle.t2a.x1d.x2g, z4.tle.t2a.xld.x2h, z4.tle.t2a.xle.x2a, z4.tle.t2a.xle.x2b, z4.tle.t2a.xle.x2c, z4.tle.t2a.xle.x2d, z4.tle.t2a.xle.x2e, z4.tle.t2a.xle.x2f, z4.tle.t2a.xle.x2g, z4.tle.t2a.xle.x2h, z4:tle.t2a.xlf.x2a, z4.tle.t2a.xlf.x2b, z4.tle.t2a.xlf.x2c, z4.tle.t2a.x1f.x2d, z4.tle.t2a.xlf.x2e, z4.tle.t2a.xlf.x2f, z4.tle.t2a.x1f.x2g, z4.t1e.t2a.x1f.x2h, z4.tle.t2a.xlg.x2a, z4.tle.t2a.xlg.x2b, z4.tle.t2a.xlg.x2c, z4.tle.t2a.xlg.x2d, z4.tle.t2a.xlg.x2e, z4.tle.t2a.xlg.x2f, z4.tle.t2a.xlg.x2g, z4.tle.t2a.xlg.x2h, z4.tle.t2a.xlh.x2a, z4.tle.t2a.xlh.x2b, z4.tle.t2a.xlh.x2c, z4.tle.t2a.xlh.x2d, z4.tle.t2a.xlh.x2e, z4.tle.t2a.xlh.x2f, z4.tle.t2a.xlh.x2g, z4.tle.t2a.xlh.x2h, z4.t1e.t2b.x1a.x2a, z4.tle.t2b.xla.x2b, z4.tle.t2b.xla.x2c, z4.tle.t2b.xla.x2d, z4.tle.t2b.xla.x2e, z4.tle.t2b.xla.x2f, z4.tle.t2b.xla.x2g, z4.tle.t2b.xla.x2h, z4.tle.t2b.xlb.x2a, z4.tle.t2b.xlb.x2b, z4.tle.t2b.xlb.x2c, z4.tle.t2b.xlb.x2d, z4.tle.t2b.x1b.x2e, z4.tle.t2b.xlb.x2f, z4.tle.t2b.xlb.x2g, z4.tle.t2b.xlb.x2h, z4.tle.t2b.xlc.x2a, z4.tle.t2b.xlc.x2b, z4.tle.t2b.xlc.x2c, z4.tle.t2b.xlc.x2d, z4.tle.t2b.xlc.x2e, z4.tle.t2b.xlc.x2f, z4.tle.t2b.xlc.x2g, z4.tle.t2b.xlc.x2h, z4.tle.t2b.xld.x2a, z4.tle.t2b.xld.x2b, z4.tle.t2b.xld.x2c, z4.tle.t2b.xld.x2d, z4.tle.t2b.xld.x2e, z4.tle.t2b.xld.x2f, z4.tle.t2b.xld.x2g, z4.tle.t2b.xld.x2h, z4.tle.t2b.xle.x2a, z4.tle.t2b.xle.x2b, z4.tle.t2b.xle.x2c, z4.t1e.t2b.xle.x2d, z4.tle.t2b.xle.x2e, z4.tle.t2b.xle.x2f, z4.tle.t2b.xle.x2g, z4.tle.t2b.xle.x2h, z4.tle.t2b.xlf.x2a, z4.tle.t2b.xlf.x2b, z4.tle.t2b.xlf.x2c, z4.tle.t2b.xlf.x2d, z4.tle.t2b.x1f.x2e, z4.tle.t2b.xlf.x2f, z4.tle.t2b.xlf.x2g, z4.tle.t2b.xlf.x2h, z4.tle.t2b.xlg.x2a, z4.tle.t2b.xlg.x2b, z4.tle.t2b.xlg.x2c, z4.tle.t2b.xlg.x2d, z4.tle.t2b.xlg.x2e, z4.tle.t2b.xlg.x2f, z4.tle.t2b.xlg.x2g, z4.tle.t2b.xlg.x2h, z4.tle.t2b.xlh.x2a, z4.tle.t2b.xlh.x2b, z4.tle.t2b.xlh.x2c, z4.tle.t2b.x1h.x2d, z4.tle.t2b.xlh.x2e, z4.tle.t2b.xlh.x2f, z4.tle.t2b.xlh.x2g, z4.tle.t2b.xlh.x2h, z4.t1e.t2c.xla.x2a, z4.tle.t2c.xla.x2b, z4.tle.t2c.xla.x2c, z4.tle.t2c.xla.x2d, z4.tle.t2c.xla.x2e, z4.tle.t2c.xla.x2f, z4.tle.t2c.xla.x2g, z4.tle.t2c.xla.x2h, z4.tle.t2c.xlb.x2a, z4.tle.t2c.xlb.x2b, z4.tle.t2c.xlb.x2c, z4.tle.t2c.xlb.x2d, z4.tle.t2c.xlb.x2e, z4.tle.t2c.xlb.x2f, z4.tle.t2c.xlb.x2g, z4.tle.t2c.xlb.x2h, z4.tle.t2c.x1c.x2a, z4.tle.t2c.xlc.x2b, z4.tle.t2c.xlc.x2c, z4.tle.t2c.xlc.x2d, z4.tle.t2c.xlc.x2e, z4.tle.t2c.xlc.x2f, z4.tle.t2c.xlc.x2g, z4.tle.t2c.xlc.x2h, z4.tle.t2c.xld.x2a, z4.tle.t2c.xld.x2b, z4.tle.t2c.xld.x2c, z4.tle.t2c.xld.x2d, z4.tle.t2c.xld.x2e, z4.tle.t2c.x1d.x2f; z4.tle.t2c.xld.x2g, z4.tle.t2c.xld.x2h, z4.tle.t2c.xle.x2a, z4.tle.t2c.xle.x2b, z4.tle.t2c.xle.x2c, z4.tle.t2c.xle.x2d, z4.tle.t2c.xle.x2e, z4.tle_t2c.xle.x2f, z4.tle.t2c.xle.x2g, z4.tle.t2c.x1e.x2h, z4.tle.t2c.xlf.x2a, z4.tle.t2c.x1f.x2b, z4.tle.t2c.xlf.x2c, z4.tle.t2c.xlf.x2d, z4.tle.t2c.xlf.x2e, z4.tle.t2c.xlf.x2f, z4.tle.t2c.xlf.x2g, z4.tle.t2c.xlf.x2h, z4.tle.t2c.xlg.x2a, z4.tle.t2c.xlg.x2b, z4.tle.t2c.xlg.x2c, z4.tle.t2c.xlg.x2d, z4.tle.t2c.xlg.x2e, z4.tle.t2c.xlg.x2f, z4.tle.t2c.xlg.x2g, z4.tle.t2c.xlg.x2h, z4.tle.t2c.xlh.x2a, z4.tle.t2c.xlh.x2b, z4.tle.t2c.xlh.x2c, z4.tle.t2c.xlh.x2d, z4.tle.t2c.xlh.x2e, z4.tle.t2c.xlh.x2f, z4.tle.t2c.xlh.x2g, z4.tle.t2c.xlh.x2h, z4.tle.t2d.xla.x2a, z4.tle.t2d.xla.x2b, z4.t1e.t2d.xla.x2c, z4.tle.t2d.xla.x2d, z4.tle.t2d.xla.x2e, z4.tle.t2d.xla.x2f, z4.tle.t2d.xla.x2g, z4.tle.t2d.xla.x2h;

z4.tle.t2d.xlb.x2a, z4.tle.t2d.xlb.x2b, z4.tle.t2d.xib.x2c, z4.tle.t2d.xlb.x2d, z4.tle.t2d.xlb.x2e, z4.tle.t2d.xlb.x2f, z4.tle.t2d.xlb.x2g, z4.tle.t2d.xlb.x2h, z4.tle.t2d.xlc.x2a, z4.tle.t2d.xlc.x2b, z4.tle.t2d.xlc.x2c, z4.tle.t2d.xlc.x2d, z4.tle.t2d.xlc.x2e, z4.tle.t2d.xlc.x2f, z4.tle.t2d.xlc.x2g, z4.tle.t2d.xlc.x2h, z4.tle.t2d.xld.x2a, z4.tle.t2d.xld.x2b, z4.tle.t2d.xld.x2c, z4.tle.t2d.xld.x2d, z4.tle.t2d.xld.x2e, z4.tle.t2d.xld.x2f, z4.tle.t2d.xld.x2g, z4.tle.t2d.xld.x2h, z4.tle.t2d.xle.x2a, z4.tle.t2d.xle.x2b, z4.tle.t2d.xle.x2c, z4.t1e.t2d.xle.x2d, z4.tle.t2d.xle.x2e, z4.tle.t2d.xle.x2f, z4.tle.t2d.xle.x2g, z4.tle.t2d.xle.x2h, z4.tle.t2d.xlf.x2a, z4.tle.t2d.xlf.x2b, z4.tle.t2d.xlf.x2c, z4.tle.t2d.xlf.x2d, z4.tle.t2d.xlf.x2e, z4.tle.t2d.xlf.x2f, z4.tle.t2d.xlf.x2g, z4.tle.t2d.xlf.x2h, z4.tle.t2d.xlg.x2a, z4.tle.t2d.xlg.x2b, z4.tle.t2d.xlg.x2c, z4.tle.t2d:xlg.x2d, z4.tle.t2d.xlg.x2e, z4.tle.t2d.xlg.x2f, z4.tle.t2d.xlg.x2g, z4.tle.t2d.xlg.x2h, z4.tle.t2d.xlh.x2a, z4.tle.t2d.xlh.x2b, z4.tle.t2d.xlh.x2c, z4.tle.t2d.xlh.x2d, z4.tle.t2d.xlh.x2e, z4.t1e.t2d.x1h.x2f, z4.tle.t2d.xlh.x2g, z4.tle.t2d.xlh.x2h, z4.tle.t2e.xla.x2a, z4.tle.t2e.xla.x2b, z4.tle.t2e.xla.x2c, z4.tle.t2e.xla.x2d, z4.tle.t2e.xla.x2e, z4.tle.t2e.xla.x2f, z4.tle.t2e.xla.x2g, z4.tle.t2e.xla.x2h, z4.tle.t2e.xlb.x2a, z4.tle.t2e.xlb.x2b, z4.tle.t2e.xlb.x2c, z4.tle.t2e.xlb.x2d, z4.tle.t2e.xlb.x2e, z4.tle.t2e.xlb.x2f, z4.tle.t2e.xlb.x2g, z4.tle.t2e.xlb.x2h, z4.tle.t2e.xlc.x2a, z4.tle.t2e.xlc.x2b, z4.tle.t2e.xlc.x2c, z4.tle.t2e.xlc.x2d, z4.tle.t2e.xlc.x2e, z4.tle.t2e.xlc.x2f, z4.tle.t2e.xlc.x2g, z4.tle.t2e.xlc.x2h, z4.tle.t2e.xld.x2a, z4.tle.t2e.xld.x2b, z4.tle.t2e.xld.x2c, z4.tle.t2e.xld.x2d, z4.tle.t2e.xld.x2e, z4.tle.t2e.xld.x2f, z4.tle.t2e.xld.x2g, z4.tle.t2e.xld.x2h, z4.tle.t2e.xle.x2a, z4.tle.t2e.xle.x2b, z4.tle.t2e.xle.x2c, z4.tle.t2e.xle.x2d, z4.tle.t2e.xle.x2e, z4.tle.t2e.xle.x2f, z4.tle.t2e.xle.x2g, z4:tle.t2e.xle.x2h, z4.tle.t2e.xlf.x2a, z4.tle.t2e.xlf.x2b, z4.tle.t2e.xlf.x2c, z4.tle.t2e.xlf.x2d, z4.tle.t2e.x1f.x2e, z4.tle.t2e.xlf.x2f, z4.tle.t2e.xlf.x2g, z4.tle.t2e.xlf.x2h, z4.tle.t2e.xlg.x2a, z4.tle.t2e.xlg.x2b, z4.tle.t2e.xlg.x2c, z4.tle.t2e.xlg.x2d, 24.tle.t2e.xlg.x2e, z4.tle.t2e.xlg.x2f, z4.tle.t2e.xlg.x2g, z4.tle.t2e.xlg.x2h, z4.tle.t2e.xlh.x2a, z4.tle.t2e.xlh.x2b, z4.tle.t2e.xlh.x2c, z4.tle.t2e.xlh.x2d, z4.tle.t2e.xlh.x2e, z4.tle.t2e.xlh.x2f, z4.tle.t2e.xlh.x2g, z4.tle.t2e.xlh.x2h, z5.tla.t2a.xla.x2a, z5.tla.t2a.xla.x2b, z5.t1a.t2a.xla.x2c, z5.tla.t2a.xla.x2d, z5.tla.t2a.x1a.x2e, z5.tla.t2a.xla.x2f, z5.t1a.t2a.xla.x2g, z5.tla.t2a.xla.x2h, z5.t1a.t2a.xlb.z2a, z5.tla.t2a.xlb.x2b, z5.tla.t2a.xlb.x2c, z5.tla.t2a.xlb.x2d, z5.t1a.t2a.xlb.x2e,'z5.tla.t2a.xlb.x2f, z5.tla.t2a.xlb.x2g, z5.t1a.t2a.xlb.x2h, z5.tla.t2a.xlc.x2a, z5.tla.t2a.xlc.x2b, z5.tla.t2a.xlc.x2c, z5.tla.t2a.xlc.x2d, z5.tla.t2a.xlc.x2e, z5.tla.t2a.xlc.x2f, z5.tla.t2a.xlc.x2g, z5.t1a.t2a.xlc.x2h, z5.tla.t2a.xld.x2a, z5.tla.t2a.xld.x2b, z5.tla.t2a.xld.x2c, z5.tla.t2a.xld.x2d, z5.tla.t2a.xld.x2e, z5.tla.t2a.xld.x2f, z5.tla.t2a.xld.x2g, z5.tla.t2a.xld.x2h, z5.tla.t2a.xle.x2a, z5.tla.t2a.xle.x2b, z5.tla.t2a.xle.x2c, z5.tla.t2a.xle.x2d, z5.tla.t2a.xle.x2e, z5.tla.t2a.xle.x2f, z5.t1a.t2a.xle.x2g, z5.tla.t2a.xle.x2h, z5.tla.t2a.xlf.x2a, z5.tla.t2a.xlf.x2b, z5.tla.t2a.xlf.x2c, z5.tla.t2a.xlf.x2d, z5.tla.t2a.xlf.x2e, z5.tla.t2a.xlf.x2f, z5.tla.t2a.xlf.x2g, z5.tla.t2a.xlf.x2h,-z5.tla.t2a.xlg.x2a, z5.tla.t2a.xlg.x2b, z5.tla.t2a.xlg.x2c, z5.tla.t2a.xlg.x2d, z5.tla.t2a.xlg.x2e, z5.tla.t2a.x1g.x2f, z5.tla.t2a.xlg.x2g, z5.tla.t2a.xlg:x2h, z5.tla.t2a.xlh.x2a, z5.tla.t2a.xlh.x2b, z5.tla.t2a.xlh.x2c, z5.t1a.t2a.xlh.x2d, z5.tla.t2a.xlh.x2e, z5.tla.t2a.xlh.x2f, z5.tla.t2a.xlh.x2g, z5.tla.t2a.xlh.x2h, z5.tla.t2b.xla.x2a, z5.t1a.t2b.x1a.x2b, z5.tla.t2b.xla.x2c, z5.tla.t2b.xla.x2d, z5.tla.t2b.xla.x2e, z5.tla.t2b.xla.x2f, z5.tla.t2b.xla.x2g, z5.tla.t2b.xla.x2h, z5.tla.t2b.xlb.x2a, z5.tla.t2b.xlb.x2b, z5.tla.t2b.xlb.x2c, z5.tla.t2b.xlb.x2d, z5.tla.t2b.xlb.x2e, z5.tla.t2b.xlb.x2f, z5.tla.t2b.xlb.x2g, z5.tla.t2b.xlb.x2h, z5.tla.t2b.xlc.x2a, z5.tla.t2b.xlc.x2b, z5.tla.t2b.xlc.x2c, z5.tla.t2b.xlc.x2d, z5.tla.t2b.xlc.x2e, z5.tla.t2b.xlc.x2f, z5.tla.t2b.xlc.x2g, z5.tla.t2b.xlc.x2h, z5.tla.t2b.xld.x2a, z5.t1a.t2b.xld.x2b, z5.tla.t2b.xld.x2c, z5.tla.t2b.xld.x2d, z5.tla.t2b.xld.x2e, z5.tla.t2b.xld.x2f, z5.tla.t2b.xld.x2g, z5.tla.t2b.xld.x2h, z5.tla.t2b.xle.x2a, z5.tla.t2b.xle.x2b, z5.tla.t2b.xle.x2c, z5.tla.t2b.xle.x2d, z5.tla.t2b.xle.x2e, z5.tla.t2b.xle.x2f, z5.tla.t2b.xle.x2g, z5.tla.t2b.xle.x2h, z5.tla.t2b.x1f.x2a, z5.tla.t2b.xlf.x2b, z5.tla.t2b.xlf.x2c, z5.t1a.t2b.x1f.x2d, z5.tla.t2b.xlf.x2e, z5.tla.t2b.xlf.x2f, z5.tla.t2b.xlf.x2g, z5.tla.t2b.xlf.x2h, z5.tla.t2b.xlg.x2a, z5.tla.t2b.xlg.x2b, z5.tla.t2b.xlg.x2c, z5.tla.t2b.xlg.x2d, z5.tla.t2b.xlg.x2e, z5.tla.t2b.xlg.x2f, z5.tla.t2b.xlg.x2g, z5.tla.t2b.xlg.x2h, z5.t1a.t2b.xlh.x2a, z5.tla.t2b.xlh.x2b, z5.tla.t2b.xlh.x2c, z5.tla.t2b.xlh.x2d, z5.tla.t2b.xlh.x2e, z5.tla.t2b.xlh.x2f, z5.tla.t2b.x1h.x2g, z5.tla.t2b.xlh.x2h, z5.tla:t2c.xla.x2a, z5.tla.t2c.xla.x2b, z5.tla.t2c.xla.x2c, z5.tla.t2c.x1a.x2d, z5.tla.t2c.xla.x2e, z5.tla.t2c.xla.x2f, z5.tla.t2c.xla.x2g, z5.t1a.t2c.x1a.x2h, z5.tla.t2c.xlb.x2a, z5.tla.t2c.xlb.x2b, z5.tla.t2c.xlb.x2c, z5.tla.t2c.xlb.x2d, z5.t1a.t2c.x1b.x2e, z5.t1a.t2c.x1b.x2f, z5.tla.t2c.xlb.x2g, z5.tla.t2c.xlb.x2h, z5.tla.t2c.xlc.x2a, z5.tla.t2c.xlc.x2b, z5.tla.t2c.xlc.x2c, z5.tla.t2c.xlc.x2d, z5.tla.t2c.xlc.x2e, z5.tla.t2c.xlc.x2f, z5.tla.t2c.xlc.x2g, z5.tla.t2c.xlc.x2h, z5.tla.t2c.xld.x2a, z5.tla.t2c.xld.x2b, z5.tla.t2c.xld.x2c, z5.tla.t2c.xld.x2d, z5.tla.t2c.xld.x2e, z5.tla.t2c.xld.x2f, z5.tla.t2c.xld.x2g, z5.tla.t2c.xld.x2h, z5.tla.t2c.xle.x2a, z5.t1a.t2c.xle.x2b, z5.tla.t2c.x1e.x2c, z5.tla.t2c.xle.x2d, z5.tla.t2c.xle.x2e, z5.tla.t2c.xle.x2f, z5.tla.t2c.xle.x2g, z5.tla.t2c.xle.x2h, z5.tla.t2c.xlf.x2a, z5.tla.t2c.xlf.x2b, z5.tla.t2c.xlf.x2c, z5.tla.t2c.xlf.x2d, z5.tla.t2c.xlf.x2e, z5.tla.t2c.xlf.x2f, z5.tla.t2c.xlf.x2g, z5.tla.t2c.xlf.x2h, z5.tla.t2c.x1g.x2a, z5.tla.t2c.xlg.x2b, z5.tla.t2c.xlg.x2c, z5.tla.t2c.xlg.x2d, z5.tla.t2c.xlg.x2e, z5.t1a.t2c.xlg.x2f, z5.tla.t2c.xlg.x2g, z5.tla.t2c.xlg.x2h, z5.tla.t2c.xlh.x2a, z5.tla.t2c.x1h.x2b, z5.tla.t2c.xlh.x2c, z5.tla.t2c.xlh.x2d, z5.tla.t2c.xlh.x2e, z5.tla.t2c.xlh.x2f, z5.tla.t2c.xlh.x2g, z5.tla.t2c.xlh.x2h, z5.tla.t2d.xla.x2a, z5.tla.t2d.xla.x2b, z5.tla.t2d.xla.x2c, z5.tla.t2d.xla.x2d, z5.tla.t2d.xla.x2e, z5.tla.t2d.xla.x2f, z5.tla.t2d.xla.x2g, z5.tla.t2d.xla.x2h, z5.t1a.t2d.xlb.x2a, z5.tla.t2d.xlb.x2b, z5.tla.t2d.xlb.x2c, z5.tla.t2d.xlb.x2d, z5.tla.t2d.xlb.x2e, z5.tla.t2d.xlb.x2f, z5.tla.t2d.xlb.x2g, z5.tla.t2d.xlb.x2h, z5.tla.t2d.x1c.x2a, z5.tla.t2d.x1c.x2b, z5.t1a.t2d.xlc.x2c, z5.tla.t2d.xlc.x2d, z5.tla.t2d.xlc.x2e, z5.tla.t2d.xlc.x2f, z5.t1a.t2d.xlc.x2g, z5.tla.t2d.xlc.x2h, z5.tla.t2d.xld.x2a, z5.tla.t2d.xld.x2b, z5.tla.t2d.xld.x2c, z5.tla.t2d.xld.x2d, z5.tla.t2d.xld.x2e, z5.tla.t2d.xld.x2f, z5.tla.t2d.xld.x2g, z5.tla.t2d.xld.x2h,.
z5.tla.t2d.xle.x2a, z5.tla.t2d.xle.x2b, z5.tla.t2d.xle.x2c, z5.tla.t2d.xle.x2d, z5.tla.t2d.xle.x2e, z5.tla.t2d.xle.x2f, z5.tla.t2d.xle.x2g, z5.tla.t2d.xle.x2h, z5.tla.t2d.xlf.x2a, z5.tla.t2d.x1f.x2b, z5.tla.t2d.xlf.x2c, z5.tla.t2d.xlf_x2d, z5.tla.t2d.xlf.x2e, z5.tla.t2d.xlf.x2f, z5.tla.t2d.xlf.x2g, z5.tla.t2d.xlf.x2h, z5.tla.t2d.xlg.x2a, z5.tla.t2d.xlg.x2b, z5.tla.t2d.xlg.x2c, z5.tla.t2d.xlg.x2d, z5.tla.t2d.xlg.x2e, z5.tla.t2d.xlg.x2f, z5.tla.t2d.xlg.x2g, z5.t1a.t2d.xlg.x2h, z5.tla.t2d.xlh.x2a, z5.tla.t2d.xlh.x2b, z5.tla.t2d.xlh.x2c, z5.tla.t2d.xlh.x2d, z5.tla.t2d.xlh.x2e, z5.tla.t2d.xlh.x2f, z5.tla.t2d.xlh.x2g, z5.tla.t2d.xlh.x2h, z5.tla.t2e.xla.x2a, z5.tla.t2e.xla.x2b, z5.tla.t2e.xla.x2c, z5.tla.t2e.xla.x2d, z5.tla.t2e.xla.x2e, z5.tla.t2e.xla.x2f, z5.tla.t2e.xla.x2g, z5.tla.t2e.xla.x2h, z5.tla.t2e.xlb.x2a, z5.tla.t2e.xlb.x2b, z5.t1a.t2e.x1b.x2c, z5.tla.t2e.xlb.x2d, z5.tla.t2e.xlb.x2e, z5.tla.t2e.xlb.x2f, z5.tla.t2e.xlb.x2g, z5.tla.t2e.xlb.x2h, z5.tla.t2e.xlc.x2a, z5.tla.t2e.xlc.x2b, z5.tla.t2e.xlc.x2c, z5.tla.t2e.x1c.x2d, z5.tla.t2e.xlc.x2e, z5.tla.t2e.xlc.x2f, z5.tla.t2e.xlc.x2g, z5.tla.t2e.xlc.x2h, z5.tla.t2e.xld.x2a, z5.tla.t2e.xld.x2b, z5.tla.t2e.xld.x2c, z5.tla.t2e.xld.x2d, z5.t1a.t2e.xld.x2e, z5.tla.t2e.xld.x2f, z5.tla.t2e.xld.x2g, z5.tla_t2e.xld.x2h, z5.tla.t2e.xle.x2a, z5.tla.t2e.xle.x2b, z5.tla.t2e.xle.x2c, z5.tla.t2e.xle.x2d, z5.tla.t2e.xle.x2e, z5.tla.t2e.xle.x2f, z5.tla.t2e.xle.x2g, z5.tla.t2e.xle.x2h, z5.tla.t2e.xlf.x2a, z5.tla.t2e.xlf.x2b, z5.tla.t2e.xlf.x2c, z5.tla.t2e.xlf.x2d, z5.tla.t2e.xlf.x2e, z5.tla.t2e.xlf.x2f, z5.tla.t2e.xlf.x2g, z5.tla.t2e.xlf.x2h, z5.tla.t2e.xlg.x2a, z5.tla.t2e.xlg.x2b, z5.tla.t2e.xlg.x2c, z5.tla.t2e.xlg.x2d, z5.tla.t2e.xlg.x2e, z5.t1a.t2e_x1g.x2f, z5.tla.t2e.xlg.x2g, z5.tla.t2e.xlg.x2h, z5.tla.t2e.x1h.x2a, z5.tla.t2e.xlh.x2b, z5.tla.t2e.xlh.x2c, z5.tla.t2e.xlh.x2d, z5.t1a.t2e.xlh.x2e, z5.tla.t2e.xlh.x2f, z5.tla.t2e.xlh.x2g, z5.tla.t2e.xlh.x2h, z5.tlb.t2a.xla.x2a, z5.tlb.t2a.xla.x2b, z5.tlb.t2a.xla.x2c, z5.tlb.t2a.xla.x2d, z5.tlb.t2a.xla.x2e, z5.tlb.t2a.xla.x2f, z5.tlb.t2a.xla.x2g, z5.tlb.t2a.xla.x2h, z5.tlb.t2a.xlb.x2a, z5.tlb.t2a.xlb.x2b, z5.tlb.t2a.xlb.x2c, z5.tlb.t2a.xlb.x2d, z5.tlb.t2a.xlb.x2e, z5.tlb.t2a.xlb.x2f, z5.tlb.t2a.x1b.x2g, z5.tlb.t2a.xlb.x2h, z5.tlb.t2a.xlc.x2a, z5.tlb.t2a.xlc.x2b, z5.tlb.t2a.xlc.x2c, z5.tlb.t2a.xlc.x2d, z5.tlb.t2a.xlc.x2e, z5.tlb.t2a.xlc.x2f, z5.tlb.t2a.xlc.x2g, z5.tlb.t2a.xlc.x2h, z5.tlb.t2a.xld.x2a, z5.tlb.t2a.xld.x2b, z5.tlb.t2a.xld.x2c, z5.tlb.t2a.xld.x2d, z5.tlb.t2a.xld.x2e, z5.tlb.t2a.xld.x2f, z5.tlb.t2a.xld.x2g, z5.tlb.t2a.xld.x2h, z5.tlb.t2a.xle.x2a, z5.tlb.t2a.xle.x2b, z5.tlb.t2a.xle.x2c, z5.tlb.t2a.xle.x2d, z5.tlb.t2a.xle.x2e, z5.tlb.t2a.xle.x2f, z5.tlb.t2a.xle.x2g, z5.tlb.t2a.xle.x2h, z5.tlb.t2a.xlf.x2a, z5.tlb.t2a.xlf.x2b, z5.tlb.t2a.x1f.x2c, z5.tlb.t2a.xlf.x2d, z5.tlb.t2a.xlf.x2e, z5.tlb.t2a.xlf.x2f, z5.tlb.t2a.xlf.x2g, z5.tlb.t2a.xlf.x2h, z5.tlb.t2a.xlg.x2a, z5.tlb.t2a.xlg.x2b, z5.tlb.t2a.xlg.x2c, z5.tlb.t2a.xlg.x2d, z5.tlb.t2a.xlg.x2e, z5.tlb.t2a.xlg.x2f, z5.tlb.t2a.xlg.x2g, z5.tlb.t2a.xlg.x2h, z5.tlb.t2a.xlh.x2a, z5.t1b:t2a.x1h.x2b, z5.tlb.t2a.xlh.k2c, z5.tlb.t2a.xlh.x2d, z5.tlb.t2a.xlh.x2e, z5.tlb.t2a.xlh.x2f, z5.tlb.t2a.xlh.x2g, z5.tlb.t2a.xlh.x2h, z5.tlb.t2b.xla.x2a, z5.tlb.t2b.xla.x2b, z5.tlb.t2b.xla.x2c, z5.tlb.t2b.xla.x2d, z5.tlb.t2b.xla.x2e; z5.t1b.t2b.xla.x2f, z5.tlb.t2b.xla.x2g, z5.tlb.t2b.xla.x2h, z5.tlb.t2b.xlb.x2a, z5.tlb.t2b.xlb.x2b, z5.tlb.t2b.xlb.x2c, z5.tlb.t2b.xlb.x2d, z5.tlb.t2b.xlb.x2e, z5.tlb.t2b.xlb.x2f, z5.tlb.t2b.xlb.x2g, z5.tlb.t2b.xlb.x2h, z5.tlb.t2b.xlc.x2a, z5.tlb.t2b.xlc.x2b, z5.tlb.t2b.xlc.x2c, z5.tlb.t2b.xlc.x2d, z5.tlb.t2b.xlc.x2e, z5.tlb.t2b.xlc.x2f, z5.tlb.t2b.xlc.x2g, z5.tlb.t2b.xlc.x2h, z5.tlb.t2b.xld.x2a, z5.t1b.t2b.xld.x2b, z5.tlb.t2b.xld.x2c, z5.tlb.t2b.xld.x2d, z5.tlb.t2b.xld.x2e, z5.tlb.t2b.x1d.x2f, z5.tlb.t2b.xld.x2g, z5.tlb.t2b.xld.x2h, z5.tlb.t2b.xle.x2a, z5.tlb.t2b.xle.x2b, z5.tlb.t2b.xle.x2c, z5.tlb.t2b.xle.x2d, z5.tlb.t2b.xle.x2e, z5.tlb.t2b.xle.x2f, z5.tlb.t2b.xle.x2g, z5.tlb.t2b.xle.x2h, z5.tlb.t2b.xlf.x2a, z5.tlb.t2b.xlf.x2b, z5.t1b.t2b.xlf.x2c, z5.tlb.t2b.xlf.x2d, z5.tlb.t2b.xlf.x2e, z5.tlb.t2b.xlf.x2f, z5.tlb.t2b.xlf.x2g, z5.tlb.t2b.xlf.x2h, z5.tlb.t2b.xlg.x2a, z5.tlb.t2b.xlg.x2b, z5.tlb.t2b.xlg.x2c, z5.tlb.t2b.xlg.x2d, z5.tlb.t2b.xlg.x2e, z5.tlb.t2b.xlg.x2f, z5.tlb.t2b.xlg.x2g, z5.tlb.t2b.xlg.x2h, z5.tlb.t2b.xlh.x2a, z5.tlb.t2b.xlh.x2b, z5.tlb.t2b.x1h.x2c, z5.tlb.t2b.xlh.x2d, z5.tlb.t2b.xlh.x2e, z5.tlb.t2b.xlh.x2f, z5.tlb.t2b.xlh.x2g, z5.tlb.t2b.xlh.x2h, z5.tlb.t2c.xla.x2a, z5.tlb.t2c.xla.x2b, z5.tlb.t2c.xla.x2c, z5.tlb.t2c.xla.x2d, z5.tlb.t2c.xla.x2e, z5.tlb.t2c.xla.x2f, z5.tlb.t2c.xla.x2g, z5.tlb.t2c.x1a.x2h, z5.tlb.t2c.xlb.x2a, z5.tlb.t2c.xlb.x2b, z5.tlb.t2c.xlb.x2c, z5.tlb.t2c.xlb.x2d, z5.tlb.t2c.xlb.x2e, z5.tlb.t2c.xlb.x2f, z5.tlb.t2c.xlb.x2g, z5.tlb.t2c.xlb.x2h, z5.tlb.t2c.xlc.x2a, z5.tlb.t2c.xlc.x2b, z5.tlb.t2c.xlc.x2c, z5.tlb.t2c.xlc.x2d, z5.tlb.t2c.xlc.x2e, z5.tlb.t2c.xlc.x2f, z5.tlb.t2c.xlc.x2g, z5.tlb.t2c.xlc.x2h, z5.tlb.t2c.xld.x2a, z5.tlb.t2c.xld.x2b, z5.tlb.t2c.xld.x2c, z5.tlb.t2c.xld.x2d, z5.tlb.t2c.xld.x2e, z5.tlb.t2c.xld.x2f, z5.tlb.t2c.xld.x2g, z5.tlb.t2c.xld.x2h, z5.tlb.t2c.xle.x2a, z5.tlb.t2c.xle.x2b, z5.tlb.t2c.xle.x2c, z5.tlb.t2c.xle.x2d, z5.tlb.t2c.xle.x2e, z5.tlb.t2c.xle.x2f, z5.tlb.t2c.xle.x2g, z5.tlb.t2c.xle.x2h, z5.tlb.t2c.xlf.x2a, z5.tlb.t2c.xlf.x2b, z5.tlb.t2c.xlf.x2c, z5.tlb.t2c.xlf.x2d, z5.tlb.t2c.xlf.x2e, z5.tlb.t2c.xlf.x2f, z5.tlb.t2c.xlf.x2g, z5.tlb.t2c.xlf.x2h, z5.t1b.t2c.xlg.x2a, z5.tlb.t2c.xlg.x2b, z5.tlb.t2c.xlg.x2c, z5.tlb.t2c.xlg.x2d, z5.tlb.t2c.xlg.x2e, z5.tlb.t2c.xlg.x2f, z5.tlb.t2c.xlg.x2g, z5.tlb.t2c.xlg.x2h, z5.tlb.t2c.xlh.x2a, z5.tlb.t2c.xlh.x2b, z5.tlb.t2c.xlh.x2c, z5.tlb.t2c.xlh.x2d, z5.tlb.t2c.xlh.x2e, z5.tlb.t2c.xlh.x2f, z5.tlb.t2c.xlh.x2g, z5.tlb.t2c.xlh.x2h, z5.tlb.t2d.x1a.x2a, z5.tlb.t2d.xla.x2b, z5.tlb.t2d.xla.x2c, z5.tlb.t2d.xla.x2d, z5.t1b.t2d.xla.x2e, z5.tlb.t2d.xla.x2f, z5.tlb.t2d.xla.x2g, z5.tlb.t2d.xla.x2h, z5.tlb.t2d.xlb.x2a, z5.tlb.t2d.xlb.x2b, z5.tlb.t2d.xlb.x2c, z5.tlb.t2d.xlb.x2d, z5.tlb.t2d.xlb:x2e, z5.tlb.t2d.xlb.x2f, z5.tlb.t2d.xlb.x2g, z5.tlb.t2d.xlb.x2h, z5.tlb.t2d.xlc.x2a, z5.tlb.t2d.xlc.x2b, z5.tlb.t2d.xlc.x2c, z5.tlb.t2d.xlc.x2d, z5.tlb.t2d.xlc.x2e, z5.tlb.t2d.xlc.x2f, z5.tlb.t2d.xlc.x2g, z5.tlb.t2d.xlc.x2h, z5.tlb.t2d.xld.x2a, z5.tlb.t2d.xld.x2b, z5.tlb.t2d.xld.x2c, z5.tlb.t2d.xld.x2d, z5.tlb.t2d.xld.x2e, z5.t1b.t2d.zld.x2f, z5.tlb.t2d.xld.x2g, z5.tlb.t2d.xld.x2h, z5.tlb.t2d.xle.x2a, z5.t1b.t2d.xle.x2b, z5.tlb.t2d.xle.x2c, z5.tlb.t2d.xle.x2d, z5.tlb.t2d.xle.x2e, z5.tlb.t2d.xle.x2f, z5.tlb.t2d.xle.x2g, z5.tlb.t2d.xle.x2h, z5.tlb.t2d.xlf.x2a, z5.tlb.t2d.xlf.x2b, z5.tlb.t2d.xlf.x2c, z5.tlb.t2d.xlf.x2d, z5.tlb.t2d.xlf.x2e, z5.tlb.t2d.xlf.x2f, z5.tlb.t2d.xlf.x2g, z5.tlb.t2d.xlf.x2h, z5.tlb.t2d.xlg.x2a, z5.tlb.t2d.xlg.x2b, z5.tlb.t2d.xlg.x2c, z5.tlb.t2d.xlg.x2d, z5.tlb.t2d.xlg.x2e, z5.tlb.t2d.xlg.x2f, z5.tlb.t2d.xlg.x2g, z5.tlb.t2d.xlg.x2h, z5.tlb.t2d.xlh.x2a, z5.tlb.t2d.xlh.x2b, z5.t1b.t2d.x1h.x2c, z5.tlb.t2d.xlh.x2d, z5.tlb.t2d.xlh.x2e, z5.t1b.t2d.xlh.x2f, z5.tlb.t2d.xlh.x2g, z5.tlb.t2d.xlh.x2h, z5.tlb.t2e.xla.x2a, z5.tlb.t2e.xla.x2b, z5.tlb.t2e.xla.x2c, z5.tlb.t2e.xla.x2d, z5.tlb.t2e.xla.x2e, z5.tlb.t2e.xla.x2f, z5.tlb.t2e.xla.x2g, z5.tlb.t2e.xla.x2h, z5.tlb.t2e.xlb.x2a, z5.tlb.t2e.xlb.x2b, z5.tlb.t2e.xlb.x2c, z5.tlb.t2e.xlb.x2d, z5.tlb.t2e.xlb.x2e, z5.tlb.t2e.xlb.x2f, z5.tlb.t2e.xlb.x2g, z5.tlb.t2e.xlb.x2h, z5.tlb.t2e.xlc.x2a, z5.tlb.t2e.xlc.x2b, z5.tlb.t2e.xlc.x2c, z5.tlb.t2e.xlc.x2d, z5.tlb.t2e.x1c.x2e, z5.tlb.t2e.xlc.x2f, z5.tlb.t2e.xlc.x2g, z5.tlb.t2e.xlc.x2h, z5.tlb.t2e.xld.x2a, z5.tlb.t2e.xld.x2b, z5.tlb.t2e.xld.x2c, z5.tlb.t2e.xld.x2d, z5.tlb.t2e.xld.x2e, z5.tlb.t2e.xld.x2f, z5.tlb.t2e.xld.x2g, z5.t1b.t2e.x1d.x2h, z5.tlb.t2e.xle.x2a, z5.tlb.t2e.xle.x2b, z5.tlb.t2e.xle.x2c, z5.tlb.t2e.xle.x2d, z5.tlb.t2e.xle.x2e, z5.tlb.t2e.xle.x2f, z5.tlb.t2e.xle.x2g, z5.tlb.t2e.xle.x2h, z5.tlb.t2e.xlf.x2a, z5.tlb.t2e.xlf.x2b, z5.t1b.t2e.xlf.x2c, z5.tlb.t2e.xlf.x2d, z5.tlb.t2e.xlf.x2e, z5.tlb.t2e.xlf.x2f, z5.tlb.t2e.xlf.x2g, z5.tlb.t2e.xlf.x2h, z5.tlb.t2e.xlg.x2a, z5.tlb.t2e.xlg.x2b, z5.tlb.t2e.xlg.x2c, z5.t1b.t2e.xlg.x2d, z5.tlb.t2e.x1g.x2e, z5.tlb.t2e.xlg.x2f, z5.tlb.t2e.xlg.x2g, z5.tlb.t2e.xlg.x2h, z5.tlb.t2e.xlh.x2a, z5.tlb.t2e.xlh.x2b, z5.tlb.t2e.xlh.x2c, z5.tlb.t2e.xlh.x2d, z5.tlb.t2e.xlh.x2e, z5.tlb.t2e.xlh.x2f, z5.tlb.t2e.xlh.x2g, z5.tlb.t2e.xlh.x2h, z5.tlc.t2a.xla.x2a, z5.tlc.t2a.x1a.x2b, z5.tlc.t2a.xla.x2c, z5.tlc.t2a.xla.x2d, z5.tlc.t2a.xla.x2e, z5.tlc.t2a.xla.x2f, z5.tlc.t2a.xla.x2g, z5.tlc.t2a.xla.x2h, z5.tlc.t2a.xlb.x2a, z5.tlc.t2a.xlb.x2b, z5.tlc.t2a.xlb.x2c, z5.tlc.t2a.xlb.x2d, z5.tlc.t2a.xlb.x2e, z5.tlc.t2a.xlb.x2f, z5.tlc.t2a.xlb.x2g, z5.tlc.t2a.x1b.x2h, z5.tlc.t2a.xlc.x2a, z5.tlc.t2a.xlc.x2b, z5.t1c.t2a.xlc.x2c, z5.tlc.t2a.xlc.x2d, z5.tlc.t2a.xlc.x2e, z5.tlc.t2a.xlc.x2f, z5.tlc.t2a.xlc.x2g, z5.tlc.t2a.xlc.x2h, z5.tlc.t2a.xld.x2a, z5.tlc.t2a.xld.x2b, z5.tlc.t2a.xld.x2c, z5.tlc.t2a.xld.x2d, z5.t1c.t2a.xld.x2e, z5.tlc.t2a.xld.x2f, z5.tlc.t2a.xld.x2g, z5.tlc.t2a.xld.x2h, z5.tlc.t2a.xle.x2a, z5.tlc.t2a.xle.x2b, z5.tlc.t2a.xle.x2c, z5.tlc.t2a.xle.x2d, z5.t1c.t2a.xle.x2e, z5.tlc.t2a.xle.x2f, z5.tlc.t2a.xle.x2g, z5.tlc.t2a.xle.x2h, z5.tlc.t2a.xlf.x2a, z5.t1c.t2a.xlf.x2b; z5.tlc.t2a.xlf.x2c, z5.tlc.t2a.xlf.x2d, z5.tlc.t2a.xlf.x2e, z5.tlc.t2a.xlf.x2f, z5.tlc.t2a.xlf.x2g, z5.tlc.t2a.xlf.x2h, z5.tlc.t2a.xlg.x2a, z5.tlc.t2a.xlg.x2b, z5.tlc.t2a.xlg.x2c, z5.tlc.t2a.xlg.x2d, z5.t1c.t2a.xlg_x2e, z5.tlc.t2a.xlg.x2f, z5.t1c.t2a.xlg.x2g, z5.tlc.t2a.xlg.x2h, z5.tlc.t2a.xlh.x2a, z5.tlc.t2a.xlh.x2b, z5.tlc.t2a.xlh.x2c, z5.tlc.t2a.xlh.x2d, z5.tlc.t2a.xlh.x2e, z5.tlc.t2a.xlh.x2f, z5.tlc.t2a.xlh.x2g, z5.tlc.t2a.xlh.x2h, z5.tlc.t2b.xla.x2a, z5.tlc.t2b.xla.x2b, z5.tlc.t2b.xla.x2c, z5.tlc.t2b.xla.x2d, z5.tlc.t2b.xla.x2e, z5.tlc.t2b.xla.x2f, z5.tlc.t2b.xla.x2g, z5.tlc.t2b.xla.x2h, z5.tlc.t2b.xlb.x2a, z5.tlc.t2b.xlb.x2b, z5.tlc.t2b.xlb.x2c, z5.tlc.t2b.xlb.x2d, z5.tlc.t2b.xlb.x2e, z5.tlc.t2b.xlb.x2f, z5.t1c.t2b.xlb.x2g, z5.tlc.t2b.xlb.x2h, z5.tlc.t2b.xlc.x2a, z5.tlc.t2b.xlc.x2b, z5.tlc.t2b.xlc.x2c, z5.tlc.t2b.xlc.x2d, z5.tlc.t2b.xlc.x2e, z5.tlc.t2b.xlc.x2f, z5.tlc.t2b.xlc.x2g, z5.tlc.t2b.xlc.x2h, z5.tlc.t2b.xld.x2a, z5.tlc.t2b.xld.x2b, z5.tlc.t2b.xid.x2c, z5.tlc.t2b.xld.x2d, z5.t1c.t2b.xld.x2e; z5.tlc.t2b.xld_x2f, z5.tlc.t2b.xld.x2g, z5.tlc.t2b.xld.x2h, z5.tlc.t2b.xle.x2a, z5.tlc.t2b.xle.x2b, z5.tlc.t2b.xle.x2c, z5.tlc.t2b.xle.x2d, z5.tlc.t2b.xle.x2e, z5.tlc.t2b.xle.x2f, z5.tlc.t2b.xle:x2g, z5.tlc.t2b.xle.x2h, z5.t1c.t2b.x1f.x2a, z5.tlc.t2b.xlf.x2b, z5.tlc.t2b.xlf.x2c, z5.tlc.t2b.xlf.x2d, z5.tlc..t2b.xlf.x2e, z5.tlc.t2b.xlf.x2f, z5.tlc.t2b.xlf.x2g, z5.tlc.t2b.xlf.x2h, z5.tlc.t2b.xlg.x2a, z5.tlc.t2b.xlg.x2b, z5.tlc.t2b.xlg.x2c, z5.tlc.t2b.xlg.x2d, z5.tlc.t2b.xlg.x2e, z5.t1c.t2b.xlg.x2f, z5.tlc.t2b.xlg.x2g, z5.tlc.t2b.x1g.x2h;
z5.tlc.t2b.xlh.x2a, z5.tlc.t2b.xlh.x2b, z5.tlc.t2b.xlh.x2c, z5.tlc.t2b.x1h.x2d, z5.tlc.t2b.xlh.x2e, z5.tlc.t2b.xlh.x2f, z5.tlc.t2b.xlh.x2g, z5.tlc.t2b.xlh.x2h, z5.tlc.t2c.xla.x2a, z5.tlc.t2c.xla.x2b, z5.tlc.t2c.xla.x2c, z5.tlc.t2c.xla.x2d, z5.tlc.t2c.xla.x2e, z5.t1c.t2c.xla.x2f, z5.tlc.t2c.xla.x2g, z5.t1c.t2c.x1a.x2h, z5.tlc.t2c.xlb.x2a, z5.tlc.t2c.xlb.x2b, z5.tlc.t2c.xlb.x2c, z5.tlc.t2c.xlb.x2d, z5.tlc.t2c.xlb.x2e, z5.tlc.t2c.xlb.x2f, z5.tlc.t2c.xlb.x2g, z5.tlc.t2c.xlb.x2h, z5.tlc.t2c.xlc.x2a, z5.tlc.t2c.xlc.x2b, z5.tlc.t2c.xlc.x2c, z5.tlc.t2c.xlc.x2d, z5.tlc.t2c.xlc.x2e, z5.tlc.t2c.xlc.x2f, z5.tlc.t2c.xlc.x2g, z5.tlc.t2c.xlc.x2h, z5.tlc.t2c.xld.x2a, z5.tlc.t2c.xld.x2b, z5.tlc.t2c.xld.x2c, z5.tlc.t2c.xld.x2d, z5.tlc.t2c.xld.x2e, z5.tlc.t2c.xld.x2f, z5.tlc.t2c.xld.x2g, z5.tlc.t2c.xld.x2h, z5.tlc.t2c.xle.x2a, z5.tlc.t2c.xle.x2b, z5.tlc.t2c.xle.x2c, z5.tlc.t2c.xle.x2d, z5.tlc.t2c.xle.x2e, z5.tlc.t2c.xle.x2f, z5.tlc.t2c.xle.x2g, z5.tlc.t2c.xle.x2h, z5.tlc.t2c.xlf.x2a; z5.tlc.t2c.xlf.x2b, z5.tlc.t2c.xlf.x2c, z5_tlc.t2c.x1f.x2d, z5.tlc.t2c.xlf.x2e, z5.tlc.t2c.xlf.x2f, z5.tlc.t2c.xlf.x2g, z5.tlc.t2c.xlf.x2h, z5.tlc.t2c.xlg.x2a, z5.tlc.t2c.xlg.x2b, z5.tlc.t2c.xlg.x2c, z5.tlc.t2c.xlg.x2d, z5.tlc.t2c.xlg.x2e, z5.tlc.t2c.xlg.x2f, z5.tlc.t2c.xlg.x2g, z5:tlc.t2c.xlg.x2h, z5.tlc.t2c.xlh.x2a, z5.tlc.t2c.xlh.x2b, z5.tlc.t2c.xlh.x2c, z5.tlc.t2c.xlh.x2d, z5.tlc.t2c.xlh.x2e, z5.tlc.t2c.xlh.x2f, z5.tlc.t2c.xlh.x2g, z5.tlc.t2c.xlh.x2h, z5.tlc.t2d.xla.x2a, z5.tlc.t2d.xla.x2b, z5.tlc.t2d.xla.x2c, z5.tlc.t2d.xla.x2d, z5.tlc.t2d.xla.x2e, z5.tlc.t2d.xla.x2f, z5.tlc.t2d.xla.x2g, z5.tlc.t2d,xla.x2h, z5.tlc.t2d.xlb.x2a, z5.tlc.t2d.xlb.x2b, z5.tlc.t2d.xlb.x2c, z5.tlc.t2d.xlb.x2d,.
z5.tlc.t2d.xlb.x2e, z5.tlc.t2d.xlb.x2f, z5.tlc.t2d.xlb.x2g, z5.tlc.t2d.xlb.x2h, z5.tlc.t2d.xlc.x2a, z5.tlc.t2d.xlc.x2b, z5.tlc.t2d.xlc.x2c, z5.tlc.t2d.xlc.x2d, z5.tlc.t2d.xlc.x2e, z5.tlc.t2d.xlc_x2f, z5.tlc.t2d.xlc.x2g, z5.tlc.t2d.xlc.x2h, z5.tlc.t2d.xld.x2a, z5.tlc.t2d.xld.x2b, z5.tlc.t2d.xld.x2c, z5.tlc.t2d.xld.x2d, z5.tlc.t2d.x1d.x2e, z5.tlc.t2d.xld.x2f, z5.tlc.t2d.xld.x2g, z5.tlc.t2d.xld.x2h, z5.tlc.t2d.xle.x2a, z5.tlc.t2d.xle.x2b, z5.tlc.t2d.xle.x2c, z5.tlc.t2d.xle.x2d, z5.tlc.t2d.xle.x2e, z5.tlc.t2d.xle.x2f, z5.tlc.t2d.x1e.x2g, z5.tlc.t2d.xle.x2h, z5.tlc.t2d.xlf.x2a, z5.tlc.t2d.xlf.x2b, z5.tlc.t2d.xlf.x2c, z5.tlc.t2d.xlf.x2d, z5.tlc.t2d.xlf.x2e, z5.tlc.t2d.xlf.x2f, z5.tlc.t2d.xlf.x2g, z5.tlc.t2d.xlf.x2h, z5.tlc.t2d.xlg.x2a, z5.tlc.t2d.xlg.x2b, z5.tlc.t2d.xlg.x2c, z5.tlc.t2d.xlg.x2d, z5.tlc.t2d.xlg.x2e, z5.tlc.t2d.xlg.x2f, z5.tlc.t2d.xlg.x2g, z5.tlc.t2d.xlg.x2h, z5.tlc.t2d.xlh.x2a, z5.tlc.t2d.xlh.x2b, z5.tlc.t2d.xlh.x2c, z5.tlc.t2d.xlh.x2d, z5.tlc.t2d.xlh.x2e, z5.t1c.t2d.xlh.x2f, z5.tlc.t2d.xlh.x2g, z5.tlc.t2d.xlh.x2h, z5.tlc.t2e.xla.x2a, z5.tlc.t2e.xla.x2b, z5.tlc.t2e.xla.x2c, z5.tlc.t2e.xla.x2d, z5.tlc.t2e.xla.x2e, z5.tlc.t2e.xla.x2f, z5.tlc.t2e.xla.x2g, z5.tlc.t2e.xla.x2h, z5.tlc.t2e.xlb.x2a, z5.tlc.t2e.xlb.x2b, z5.tlc.t2e.xlb.x2c, z5.tlc.t2e.xlb.x2d, z5.tlc.t2e.xlb.x2e, z5.tlc.t2e.xlb.x2f, z5.tlc.t2e.xlb.x2g, z5.tlc.t2e.xlb.x2h, z5.tlc.t2e.xlc.x2a, z5.tlc.t2e.xlc.x2b, z5.tlc.t2e.xlc.x2c, z5.tlc.t2e.xlc.x2d, z5.tlc.t2e.xlc.x2e, z5.tlc.t2e.xlc.x2f, z5.tlc.t2e.xlc.x2g, z5.tlc.t2e.xlc.x2h, z5.tlc.t2e.xld.x2a, z5.tlc.t2e.xld.x2b, z5.tlc.t2e.xld.x2c, z5.tlc.t2e.xld.x2d, z5.tlc.t2e.xld.x2e, z5.tlc.t2e.xld.x2f, z5.tlc.t2e.xld.x2g, z5.tlc.t2e.xld.x2h, z5.tlc.t2e.xle.x2a, z5.tlc.t2e.xle.x2b, z5.t1c.t2e.xle.x2c, z5.tlc.t2e.xle.x2d, z5.tlc.t2e.xle.x2e, z5.tlc.t2e.xle.x2f, z5.tlc.t2e.xle.x2g, z5.t1c.t2e.x1e.x2h, z5.tlc.t2e.xlf.x2a, z5.t1c.t2e.xlf.x2b, z5.tlc.t2e.xlf.x2c, z5.tlc.t2e.xlf.x2d, z5.tlc.t2e.xlf.x2e, z5.tlc.t2e.xlf.x2f, z5.tlc.t2e.xlf.x2g, z5.tlc.t2e.xlf.x2h, z5.tlc.t2e.xlg.x2a, z5.tlc.t2e.xlg.x2b, z5.tlc.t2e.xlg.x2c, z5.tlc.t2e.xlg.x2d, z5.tlc.t2e.xlg.x2e, z5.tlc.t2e.xlg.x2f, z5.tlc.t2e.xlg.x2g, z5.tlc.t2e.xlg.x2h, z5.tlc.t2e.xlh.x2a, z5.tlc.t2e.xlh.x2b, z5.tlc.t2e.xlh.x2c, z5.tlc.t2e.xlh.x2d, z5.tlc.t2e.xlh.x2e, z5.tlc.t2e.xlh.x2f, z5.tlc.t2e.xlh.x2g, z5.tlc.t2e.xlh.x2h, z5.tld.t2a.x1a.x2a, z5.tld.t2a.xla.x2b, z5.tld.t2a.xla.x2c, z5.tld.t2a.xla.x2d, z5.tld.t2a.xla.x2e, z5.tld.t2a.xla.x2f, z5.tld.t2a.xla.x2g, z5.tld.t2a.xla.x2h, z5.tld.t2a.xlb.x2a, z5.tld.t2a.xlb.x2b, z5.tld.t2a.xlb.x2c, z5.tld.t2a.xlb.x2d, z5.tld.t2a.xlb.x2e, z5.tld.t2a.xlb.x2f, z5.tld.t2a.xlb.x2g, z5.tld.t2a.xlb.x2h, z5.tld.t2a.xlc.x2a, z5.tld.t2a.xlc.x2b, z5.tld.t2a.xlc.x2c, z5.tld.t2a.xlc.x2d, z5.tld.t2a.xlc.x2e, z5.tld.t2a.xlc.x2f, z5.tld.t2a.xlc.x2g, z5.tld.t2a.xlc.x2h, z5.tld.t2a.xld.x2a, z5.tld.t2a.xld.x2b, z5.tld.t2a.xld.x2c, z5.tld.t2a.xld.x2d, z5.tld.t2a.xld.x2e, z5.tld.t2a.xld.x2f, z5.tld.t2a.xld.x2g, z5.tld.t2a.xld.x2h, z5.tld.t2a.xle.x2a, z5.tld.t2a.xle.x2b, z5.tld.t2a.xle.x2c, z5.tld.t2a.xle.x2d, z5.tld.t2a.xle.x2e, z5.tld.t2a.xle.x2f, z5.tld_t2a.xle.x2g, z5.tld.t2a.xle.x2h, z5.tld.t2a.xlf.x2a, z5.tld.t2a.xlf.x2b, z5.tld.t2a.xlf.x2c, z5.tld.t2a.xlf.x2d, z5.tld.t2a.xlf.x2e, z5.tld.t2a.xlf.x2f, z5.tld.t2a.xlf.x2g, z5.tld.t2a.xlf.x2h, z5.tld.t2a.xlg.x2a, z5.tld.t2a.xlg.x2b, z5.tld.t2a.xlg.x2c, z5.tld.t2a.xlg.x2d, z5.tld.t2a.xlg.x2e, z5.tld.t2a.xlg.x2f, z5.tld.t2a.xlg.x2g, z5.tld.t2a.xlg.x2h, z5.tld.t2a.xlh.x2a, z5.tld.t2a.xlh.x2b, z5.tld.t2a.xlh.x2c, z5.tld.t2a.xlh.x2d, z5.tld.t2a.xlh.x2e, z5.tld.t2a.xlh.x2f, z5.tld.t2a.xlh.x2g, z5.tld.t2a.xlh.x2h, z5.tld.t2b.xla.x2a, z5.tld.t2b.xla.x2b, z5.tld.t2b.xla.x2c, z5.tld.t2b.xla.x2d, z5.tld.t2b.xla.x2e, z5.tld.t2b.xla.x2f, z5.tld.t2b.xla.x2g, z5.tld.t2b.xla.x2h, z5.tld.t2b.xlb.x2a, z5.tld.t2b.x1b.x2b, z5.tld.t2b.xlb.x2c, z5.tld.t2b.xlb.x2d, z5.tld.t2b.xlb.x2e, z5.t1d.t2b.xlb.x2f, z5.t1d.t2b.xlb.x2g, z5.tld.t2b.xlb.x2h, z5.tld.t2b.xlc.x2a, z5.tld.t2b.xlc.x2b, z5.tld.t2b.xlc.x2c, z5.tld.t2b.xlc.x2d, z5.tld.t2b.xlc.x2e, z5.tld.t2b.xlc.x2f, z5.tld.t2b.xlc.x2g, z5.tld.t2b.xlc.x2h, z5.tld.t2b.xld.x2a, z5.tld.t2b.xld.x2b, z5.tld.t2b.xld.x2c, z5.tld.t2b.xld.x2d, z5.tld.t2b.xld.x2e, z5.tld.t2b.xld.x2f, z5.tld.t2b.xld.x2g, z5.tld.t2b.xld.x2h, z5.tld.t2b.xle.x2a, z5.tld.t2b.xle.x2b, z5.t1d.t2b.xle.x2c, z5.tld.t2b.xle.x2d, z5.tld.t2b.xle.x2e, z5.tld.t2b.xle.x2f, z5.tld.t2b.xle.x2g, z5.tld.t2b.xle.x2h, z5.tld.t2b.xlf.x2a, z5.tld.t2b.xlf.x2b, z5.tld.t2b.xlf.x2c, z5.tld.t2b.xlf.x2d, z5.tld.t2b.xlf.x2e, z5.tld.t2b.xlf.x2f, z5.tld.t2b.xlf.x2g, z5.tld.t2b.xlf.x2h, z5.tld.t2b.xlg.x2a, z5.tld.t2b.xlg.x2b, z5.tld.t2b.xlg.x2c, z5.tld.t2b.xlg.x2d, z5.tld.t2b.xlg.x2e, z5.tld.t2b.xlg.x2f, z5.tld.t2b.xlg.x2g, z5.tld.t2b.xlg.x2h, z5.tld.t2b.xlh.x2a, z5.tld.t2b.xlh.x2b, z5.t1d.t2b.x1h.x2c, z5.tld.t2b.xlh.x2d, z5.tld.t2b.xlh.x2e, z5.tld.t2b.xlh.x2f, z5.tld.t2b.xlh.x2g, z5.tld.t2b.xlh.x2h, z5.tld.t2c.xla.x2a, z5.tld.t2c.xla.x2b, z5.tld.t2c.xla.x2c, z5.tld.t2c.xla.x2d, z5.tld.t2c.xla.x2e, z5.tld.t2c.xla.x2f, z5.tld.t2c.xla.x2g, z5.tld.t2c.xla.x2h, z5.tld.t2c.xlb.x2a, z5.tld.t2c.xlb.x2b, z5.tld.t2c.xlb.x2c, z5.t1d.t2c.xlb.x2d, z5.tld.t2c.xlb.x2e, z5.tld.t2c.xlb.x2f, z5.tld.t2c.x1b.x2g, z5.t1d.t2c.xlb.x2h, z5.tld.t2c.xlc.x2a, z5.tld.t2c.xlc.x2b, z5.tld.t2c.xlc.x2c, z5.t1d.t2c.xlc.x2d, z5.tld.t2c.xlc.x2e, z5.t1d.t2c.xlc.x2f, z5.tld.t2c.xlc.x2g, z5.tld.t2c.xlc.x2h, z5.tld.t2c.xld.x2a,'z5.tld.t2c.xld'.x2b, z5.tld.t2c.xld.x2c, z5.t1d.t2c.x1d.x2d, z5.tld.t2c.xld.x2e, z5.tld.t2c.xld.x2f, z5.tld.t2c.xld.x2g, z5.tld.t2c.xld.x2h, z5.tld.t2c.xle.x2a, z5.tld.t2c.xle.x2b, z5.tld.t2c.xle.x2c, z5.tld.t2c.xle.x2d, z5.tld.t2c.xle.x2e, z5.tld.t2c.xle.x2f, z5.tld.t2c.xle.x2g, z5.t1d.t2c.xle.x2h, z5.tld.t2c.xlf.x2a, z5.t1d.t2c.xlf.x2b, z5.tld.t2c.xlf.x2c, z5.tld.t2c.xlf.x2d, z5.tld.t2c.xlf.x2e, z5.tld.t2c.xlf.x2f, z5.tld.t2c.xlf.x2g, z5.tld.t2c.xlf.x2h, z5.tld.t2c.xlg.x2a, z5.tld.t2c.xlg.x2b, z5.tld.t2c.xlg.x2c, z5.tld.t2c.xlg.x2d, z5.tld.t2c.xlg.x2e, z5.tld.t2c.xlg.x2f, z5.tld.t2c.xlg.x2g, z5.tld.t2c.xlg.x2h, z5.tld.t2c.xlh.x2a, z5.tld.t2c.xlh.x2b, z5.tld.t2c.xlh.x2c, z5.t1d.t2c.x1h.x2d, z5.tld.t2c.xlh.x2e, z5.tld.t2c.xlh.x2f, z5.tld.t2c.x1h.x2g, z5.t1d.t2c.xlh.x2h, z5.tld.t2d.xla.x2a, z5.tld.t2d.xla.x2b, z5.tld.t2d.xla.x2c, z5.tld.t2d.xla.x2d, z5.tld.t2d.xla.x2e, z5.tld.t2d.xla.x2f, z5.tld.t2d.xla.x2g, z5.tld.t2d.xla.x2h, z5.tld.t2d.xlb.x2a, z5.tld.t2d.xlb.x2b, z5.tld.t2d.xlb.x2c, z5.tld.t2d.xlb.x2d, z5.tld.t2d.xlb.x2e, z5.tld.t2d.xlb.x2f, z5.tld.t2d.xlb.x2g, z5.tld.t2d.xlb.x2h, z5.tld.t2d.xlc.x2a, z5.tld.t2d.xlc.x2b, z5.tld.t2d.xlc.x2c, z5.t1d.t2d.xlc.x2d, z5.tld.t2d.xlc.x2e, z5.tld.t2d.xlc.x2f, z5.tld.t2d.xlc.x2g, z5.tld.t2d.xlc.x2h, z5.tld.t2d.xld.x2a, z5.tld.t2d.xld.x2b, z5.tld.t2d.xld.x2c, z5.tld.t2d.xld.x2d, z5.tld.t2d.xld.x2e, z5.tld.t2d.xld.x2f, z5.tld.t2d.xld.x2g, z5.tld.t2d.xld.x2h, z5.tld.t2d.xle.x2a, z5.tld.t2d.xle.x2b, z5.tld.t2d.xle.x2c, z5.tld.t2d.xle.x2d, z5.tld.t2d.xle.x2e, z5.tld.t2d.x1e.x2f, z5.tld.t2d.x1e.x2g, z5.t1d.t2d.x1e.x2h, z5.tld.t2d.xlf.x2a, z5_tld.t2d.x1f.x2b, z5.tld.t2d.xlf.x2c, z5.tld.t2d.xlf.x2d, z5.tld.t2d.xlf.x2e, z5.tld.t2d.xlf.x2f, z5.tld.t2d.xlf.x2g, z5.tld.t2d.xlf.x2h, z5.tld.t2d.xlg.x2a, z5.tld.t2d.xlg.x2b, z5.tld.t2d.xlg.x2c, z5.tld.t2d.xlg.x2d, z5.tld.t2d.xlg.x2e, z5.tld.t2d.xlg.x2f, z5.tld.t2d.xlg.x2g, z5.tld.t2d.xlg.x2h, z5.tld.t2d.xlh.x2a, z5.tld.t2d.xlh.x2b, z5.tld.t2d.xlh.x2c, z5.tld.t2d.xlh.x2d, z5.tld.t2d.xlh.x2e, z5.tld.t2d.xlh.x2f, z5.tld.t2d.xlh.x2g, z5.tld.t2d.xlh.x2h, z5.t1d.t2e.xla.x2a, z5.tld.t2e.xla.x2b, z5.tld.t2e.xla.x2c, z5.tld.t2e.xla.x2d, z5.tld.t2e.xla.x2e, z5.tld.t2e.xla.x2f, z5.tld.t2e.xla.x2g, z5.tld.t2e.xla.x2h, z5.tld.t2e.xlb.x2a, z5.tld.t2e.xlb.x2b, z5.tld.t2e.xlb.x2c, z5.tld.t2e.xlb.x2d, z5.tld.t2e.xlb.x2e, z5.tld.t2e.xlb.x2f, z5.tld.t2e.xlb.x2g, z5.tld.t2e.xlb.x2h, z5.tld.t2e.xlc.x2a, z5.tld.t2e.xlc.x2b, z5.tld.t2e.xlc.x2c, z5.tld.t2e.xlc.x2d, z5.tld.t2e.xlc.x2e, z5.tld.t2e.xlc.x2f, z5.tld.t2e.xlc.x2g, z5.tld.t2e.xlc.x2h, z5.tld.t2e.xld.x2a, z5.tld.t2e.xld.x2b, z5.t1d.t2e.xld.x2c, z5.t1d.t2e.xld.x2d, z5.tld.t2e.xld.x2e, z5.tld.t2e.xld.x2f, z5.tld.t2e.xld.x2g, z5.tld.t2e.xld.x2h, z5.tld.t2e.xle.x2a, z5.tld.t2e.xle.x2b, z5.tld.t2e.xle.x2c, z5.tld.t2e.xle.x2d, z5.tld.t2e.xle.x2e, z5.t1d.t2e.xle.x2f, z5.tld.t2e.xle.x2g, z5.tld.t2e.xle.x2h, z5.tld.t2e.xlf.x2a, z5.tld.t2e.xlf.x2b, z5.tld.t2e.xlf.x2c, z5.tld.t2e.xlf.x2d, z5.tld.t2e.xlf.x2e, z5.tld.t2e.xlf.x2f, z5.tld.t2e.xlf.x2g, z5.tld_t2e.x1f.x2h, z5.tld.t2e.xlg.x2a, z5.t1d.t2e.x1g.x2b, z5.tld.t2e.x1g.x2c, z5.tld.t2e.xlg.x2d, z5.tld.t2e.xlg.x2e, z5.tld.t2e.xlg.x2f, z5.tld.t2e.xlg.x2g, z5.tld.t2e.xlg.x2h, z5.tld.t2e.xlh.x2a, z5.tld.t2e.xlh.x2b, z5.tld.t2e.xlh.x2c, z5.tld.t2e.xlh.x2d, z5.tld.t2e.xlh.x2e, z5.tld.t2e.xlh.x2f, z5.tld.t2e.xlh.x2g, z5.tld.t2e.xlh.x2h, z5.tle.t2a.xla.x2a, z5.tle.t2a.xla.x2b, z5.tle.t2a.xla.x2c, z5.tle.t2a.xla.x2d, z5.tle.t2a.xla.x2e, z5.tle.t2a.xla.x2f, z5.tle.t2a.xla.x2g, z5.tle.t2a.xla.x2h, z5.tle.t2a.xlb.x2a, z5.tle.t2a.xlb.x2b, z5.tle.t2a.xlb.x2c, z5.tle.t2a.xlb.x2d, z5.tle.t2a.xlb.x2e, z5.tle.t2a.xlb.x2f, z5.tle.t2a.xlb.x2g, z5.tle.t2a.x1b.x2h, z5.tle.t2a.xlc.x2a, z5.tle.t2a.xlc.x2b, z5.tle.t2a.xlc.x2c, z5.tle.t2a.xlc.x2d, z5.t1e.t2a:xlc.x2e, z5.tle.t2a.xlc.x2f, z5.tle.t2a.x1c.x2g, z5.tle.t2a.xlc.x2h, z5.tle.t2a.xld.x2a, z5.tle.t2a.xld.x2b, z5.tle.t2a.xld.x2c, z5.tle.t2a.xld.x2d, z5.tle.t2a.xld.x2e, z5.tle.t2a.xld.x2f, z5.tle.t2a.xld.x2g, z5.tle.t2a.xld.x2h, z5.tle.t2a.xle.x2a, z5.tle.t2a.xle.x2b, z5.tle.t2a.xle.x2c, z5.tle.t2a.xle.x2d, z5.tle.t2a.xle.x2e, z5.tle.t2a.xle.x2f, z5.tle.t2a.xle.x2g, z5.tle.t2a.xle.x2h, z5.tle.t2a.xlf.x2a, z5.tle.t2a.xlf.x2b, z5.tle.t2a.xlf.x2c, z5.tle.t2a.xlf.x2d, z5.tle.t2a.xlf.x2e, z5.tle.t2a.xlf.x2f, z5.tle.t2a.xlf.x2g, z5.tle.t2a.xlf.x2h, z5.tle.t2a.xlg.x2a, z5.tle.t2a.xlg.x2b, z5.tle.t2a.xlg.x2c, z5.tle.t2a.xlg.x2d, z5.tle.t2a.xlg.x2e, z5.t1e.t2a.x1g.x2f, z5.tle.t2a.xlg.x2g, z5.tle.t2a.xlg.x2h, z5.tle.t2a.xlh.x2a, z5.tle.t2a.xlh.x2b, z5.tle.t2a.xlh.x2c, z5.tle.t2a.xlh.x2d, z5.tle.t2a.xlh.x2e, z5.tle.t2a.xlh.x2f, z5.tle.t2a.xlh.x2g, z5.tle.t2a.xlh.x2h, z5.tle.t2b.xla.x2a, z5.tle.t2b.xla.x2b, z5.tle.t2b.xla.x2c, z5.tle.t2b.xla.x2d, z5.t1e.t2b.x1a.x2e, z5.tle.t2b.xla.x2f, z5.tle.t2b.xla.x2g, z5.tle.t2b.xla.x2h, z5.tle.t2b.xlb.x2a, z5.tle.t2b.xlb.x2b, z5.tle.t2b.xlb.x2c, z5.tle.t2b.xlb.x2d, z5.tle.t2b.xlb.x2e, z5.tle.t2b.xlb.x2f, z5.tle.t2b.xlb.x2g, z5.tle.t2b.xlb.x2h, z5.tle.t2b.xlc.x2a, z5.tle.t2b.xlc.x2b, z5.tle.t2b.xlc.x2c, z5.tle.t2b.xlc.x2d, z5.tle.t2b.xlc.x2e, z5.tle.t2b.xlc.x2f, z5.tle.t2b.xlc.x2g, z5.tle.t2b.xlc.x2h, z5.tle.t2b.xld.x2a, z5.tle.t2b.xld.x2b, z5.t1e.t2b.xld.x2c, z5.tle.t2b.xld.x2d, z5.tle.t2b.xld.x2e, z5.tle.t2b.xld.x2f, z5.tle.t2b.xld.x2g, z5.tle.t2b.xld.x2h, z5.tle.t2b.xle.x2a, z5.tle.t2b.xle.x2b, z5.tle.t2b.xle.x2c, z5.tle.t2b.xle.x2d, z5.tle.t2b.xle.x2e, z5.tle.t2b.xle.x2f, z5.tle.t2b.xle.x2g, z5.tle.t2b.xle.x2h, z5.tle.t2b.xlf.x2a, z5:tle.t2b.xlf.x2b, z5.tle.t2b.xlf.x2c, z5.tle.t2b.xlf.x2d, z5.tle.t2b.xlf.x2e, z5.tle.t2b.xlf.x2f, z5.tle.t2b.xlf.x2g, z5.tle.t2b.xlf.x2h, z5.tle.t2b.xlg.x2a, z5.tle.t2b.xlg.x2b, z5.tle.t2b.xlg.x2c, z5.tle.t2b.xlg.x2d, z5.tle.t2b.xlg.x2e, z5.tle.t2b.xlg.x2f, z5.tle.t2b.xlg.x2g, z5.tle.t2b.xlg.x2h, z5.tle.t2b.xlh.x2a, z5.tle.t2b.xlh.x2b, z5.tle.t2b.xlh.x2c, z5.tle.t2b.xlh.x2d, z5.tle.t2b.xlh.x2e, z5.tle.t2b.xlh.x2f, z5.tle.t2b.xlh.x2g, z5.tle.t2b.xlh.x2h, z5.tle.t2c.xla.x2a, z5.tle.t2c.xla.x2b, z5.tle.t2c.xla.x2c, z5.tle.t2c.xla.x2d, z5.t1e.t2c.xla.x2e, z5.tle.t2c.xla.x2f, z5.tle.t2c.x1a.x2g, z5.tle.t2c.xla.x2h, z5.tle.t2c.xlb.x2a, z5.tle.t2c.xlb.x2b, z5.tle.t2c.xlb.x2c, z5.tle.t2c.xlb.x2d, z5.tle.t2c.xlb.x2e, z5.tle.t2c.xlb.x2f, z5.tle.t2c.xlb.x2g, z5.tle.t2c.xlb.x2h, z5.tle.t2c.xlc.x2a, z5.tle.t2c.xlc.x2b, z5.tle.t2c.xlc.x2c, z5.tle.t2c.xlc.x2d, z5.tle.t2c.xlc.x2e, z5.tle.t2c.xlc.x2f, z5.tle.t2c.xlc.x2g, z5.tle.t2c.xlc.x2h, z5.tle.t2c.xld.x2a, z5.tle.t2c.xld.x2b, z5.t1e.t2c.xld.x2c, z5.tle.t2c.xld.x2d, z5.t1e.t2c.xld.x2e, z5.tle.t2c.xld.x2f, z5.tle.t2c.xld.x2g, z5.tle.t2c.xld.x2h, z5.tle.t2c.xle.x2a, z5.tle.t2c.xle.x2b, z5.tle.t2c.xle.x2c, z5.tle.t2c.xle.x2d, z5.tle.t2c.xle.x2e, z5.t1e.t2c.x1e.x2f, z5.tle.t2c.xle.x2g, z5.tle.t2c.xle.x2h, z5.tle.t2c.xlf.x2a, z5.tle.t2c.xlf.x2b, z5.tle.t2c.xlf.x2c, z5.tle.t2c.xlf.x2d, z5.tle.t2c.xlf.x2e, z5.tle.t2c.xlf.x2f, z5.tle.t2c.xlf.x2g, z5.tle.t2c.xlf.x2h, z5.tle.t2c.xlg.x2a, z5.tle.t2c.xlg.x2b, z5.tle.t2c.xlg.x2c, z5.tle.t2c.xlg.x2d, z5.tle.t2c.xlg.x2e, z5.tle.t2c.xlg.x2f, z5.tle.t2c.xlg.x2g, z5.tle.t2c.xlg.x2h, z5.tle.t2c.xlh.x2a, z5.tle.t2c.xlh.x2b, z5.tle.t2c.xlh.x2c, z5.tle.t2c.xlh.x2d, z5.t1e.t2c.xlh.x2e, z5.tle.t2c.xlh.x2f, z5.tle.t2c.xlh.x2g, z5.tle.t2c.xlh.x2h, z5.tle.t2d.xla.x2a, z5.tle.t2d.xla.x2b, z5.tle.t2d.xla.x2c, z5.tle.t2d.xla.x2d, z5.tle.t2d.xla.x2e, z5.tle.t2d.xla.x2f, z5.tle.t2d.xla.x2g, z5.tle.t2d.xla.x2h, z5.tle.t2d.xlb.x2a, z5.tle.t2d.xlb.x2b, z5.tle.t2d.xlb.x2c, z5.tle.t2d.xlb.x2d, z5.tle.t2d.xlb.x2e, z5.tle.t2d.xlb.x2f, z5.tle.t2d.xlb.x2g, z5:tle.t2d.x1b.x2h, z5.tle.t2d.x1c.x2a, z5.tle.t2d.x1c.x2b, z5.t1e.t2d.xlc.x2c, z5.tle.t2d.xlc.x2d, z5.tle.t2d.xlc.x2e, z5.tle.t2d.xlc.x2f, z5.tle.t2d.xlc.x2g, z5.tle.t2d.xlc.x2h, z5.tle.t2d.xld.x2a, z5.tle.t2d.xld.x2b, z5.tle.t2d.xld.x2c, z5.tle.t2d.xld.x2d, z5.tle.t2d.xld.x2e, z5.tle.t2d.xld.x2f, z5.tle.t2d.xld.x2g, z5.tle.t2d.xld.x2h, z5.tle.t2d.xle.x2a, z5.tle.t2d.xle.x2b, z5.tle.t2d.xle.x2c, z5.tle.t2d.xle.x2d, z5.tle.t2d.xle.x2e, z5.tle.t2d.xle.x2f, z5.tle.t2d.xle.x2g, z5.tle.t2d.xle.x2h, z5.tle.t2d.xlf.x2a, z5.tle.t2d.xlf.x2b, z5.tle.t2d.xlf.x2c, z5.tle.t2d.xlf.x2d, z5.tle.t2d.xlf.x2e, z5.tle.t2d.xlf.x2f, z5.tle.t2d.xlf.x2g, z5.t1e.t2d.xlf.x2h, z5.tle.t2d.xlg.x2a, z5.tle.t2d.xlg.x2b, z5.tle.t2d.xlg.x2c, z5.tle.t2d.xlg.x2d, z5.tle.t2d.xlg.x2e, z5.tle.t2d.xlg.x2f, z5.tle.t2d.xlg.x2g, z5.tle.t2d.xlg.x2h, z5.tle.t2d.xlh.x2a, z5.tle.t2d.xlh.x2b, z5.tle.t2d.xlh.x2c, z5.tle.t2d.x1h.x2d, z5.tle.t2d.xlh.x2e, z5.tle.t2d.xlh.x2f, z5.tle.t2d.xlh.x2g, z5.tle.t2d.x1h.x2h, z5.tle.t2e.xla.x2a, z5.t1e.t2e.x1a.x2b, z5.tle.t2e.xla.x2c, z5.tle.t2e.xla.x2d, z5.tle.t2e.xla.x2e, z5.t1e.t2e.x1a.x2f, z5.tle.t2e.xla.x2g, z5.t1e.t2e.xla.x2h, z5_tle.t2e.xlb.x2a, z5.tle.t2e.xlb.x2b, z5.tle.t2e.xlb.x2c, z5.tle.t2e.x1b.x2d, z5.tle_t2e.xlb.x2e, z5.t1e.t2e.xlb.x2f, z5.tle.t2e.xlb.x2g, z5.tle.t2e.xlb.x2h, z5.tle.t2e.xlc.x2a, z5.tle.t2e.x1c.x2b, z5.tle.t2e.xlc.x2c, z5.t1e.t2e.x1c.x2d, z5.tle.t2e.xlc.x2e, z5.tle.t2e.x1c.x2f, z5.tle.t2e.xlc.x2g, z5.tle.t2e.xlc.x2h, z5.tle.t2e.xld.x2a, z5.tle.t2e.x1d.x2b, z5.t1e.t2e.xld.x2c, z5.t1e.t2e.x1d.x2d, z5.t1e.t2e.x1d.x2e, z5.tle.t2e.xld.x2f, z5.t1e.t2e.x1d.x2g, z5.t1e.t2e.xld.x2h, z5.t1e.t2e.x1e.x2a, z5.tle.t2e.xle.x2b, z5.tle.t2e.xle.x2c, z5.tle.t2e.x1e.x2d, z5.t1e.t2e.xle.x2e, z5.tle.t2e.x1e.x2f, z5.t1e.t2e.x1e.x2g, z5.t1e.t2e.x1e.x2h, z5.t1e.t2e.x1f.x2a, z5.tle.t2e.xlf.z2b, z5.t1e.t2e.x1f.x2c, z5.t1e.t2e.x1f.x2d, z5_tle_t2e.xlf.x2e, z5.tle.t2e.x1f.x2f, z5.tle.t2e.xlf.x2g, z5.t1e.t2e.xlf.x2h, z5.tle.t2e.xlg.x2a, z5.tle.t2e.xlg.x2b, z5.tle.t2e.xlg.x2c, z5.t1e.t2e.xlg.x2d, z5.t1e.t2e.xlg.x2e, z5.t1e.t2e.xlg.x2f, z5.t1e.t2e.xlg.x2g, z5.tle.t2e.xlg.x2h, z5.tle.t2e.xlh.x2a, z5.tle.t2e.xlh.x2b, z5.tle.t2e.xlh.x2c, z5.t1e.t2e.x1h.x2d, z5.t1e.t2e.x1h.x2e, z5.t1e.t2e:x1h.x2f, z5.t1e.t2e.x1h.x2g, z5.tle.t2e.xlh.x2h Phosphonate Prodrug Compounds The compounds of this invention can be phosphonate prodrug compounds (or conjugates) derived -from the compounds of Formula I. For example, the compounds of Formula I can be associated, e.g., structurally linked directly or indirectly with one or more phosphonate groups, especially phosphonate groups capable of modifying bioavailability, efficacy, or targeting site(s) of the compounds. Usually the compounds of Formula I can be directly linked to one or more phosphonate groups through a covalent bond or through a linking group, e.g., a linker. The nature of the linker is not critical provided it does not interfere with the ability of the phosphonate containing compound to function as a therapeutic agent. In general, the phosphonate or the linker can be linked to the compound at any synthetically feasible position on the compound, e.g., any solvent accessible surface by removing a. hydrogen or any portion of the compound to provide an open valence for attachment of the phosphonate or the linker.
The variables and definitions of these variables used in the present Phosphonate Prodrug Compound section of this application (e.g., A', R1, etc.) pertain only to this section of the application, unless otherwise indicated.

In one embodiment, the linking group or linker (which can be designated "L") can include all or a portion of the group A , A', A2, A', or W' described herein, such as for example, repeating units of alkyloxy (e.g., polyethylenoxy, PEG, polymethyleneoxy) and alkylamino (e.g., polyethyleneamino, Jeffamine"''"');
and diacid ester and amides including succinate, succinamide, diglycolate, malonate, and caproamide.
In another embodiment, the linking group or linker has a molecular weight of from about 20 daltons to about 400 daltons. In yet another embodiment, the linking group or linker has a length of about 5.angstroms to about 300 angstroms. In yet another embodiment, the linking group or linker separates the compound of this invention and the phosphorous of the phosphonate group by about 5 angstroms to about 200 angstroms, inclusive, in length.
In yet another embodiment, the linking group or linker is a divalent, branched or unbranched, saturated or unsaturated, hydrocarbon chain, having from 2 to 25 carbon atoms, wherein one or more (e.g. 1, 2, 3, or 4) of the carbon atoms is optionally replaced by (-O-), and wherein the chain is optionally substituted on carbon with one or more (e.g. 1, 2, 3, or 4) substituents selected from (C,-C6)alkoxy, (Cj C)cycloalkyl, (C,-C6)alkanoyl, (C,-C6)alkanoyloxy, (C,-C6Yalkoxycarbonyl, (C,-C6)alkylthio, azido, cyano, nitro, halo, hydroxy, oxo (=0), carboxy, aryl, aryloxy, heteroaryl, and heteroaryloxy.
In yet another embodiment, the linking group or Iinker is of the formula W-A wherein A is (C,-CZa)alkyl, (CZ C24)alkenyl, (Cz CZq)alkynyl, (C3 C8)cycloalkyl, (C6 C10)aryl or a combination thereof, wherein W is -N(R)C(=0)-, -C(=O)N(R)-, -OC(=O)-, =C(=0)O-, -0-, -5-, -S(O)-, -S(O)Z-, -N(R)-, -C(=0)-, or a direct bond;
wherein each R is independently H or (C,-C6)alkyl.
In yet another embodiment, the linking group or linker is a divalent radical formed from a peptide or amino acid. In yet another embodiment, the linking group or linker is a divalent radical formed from poly-L-glutamic acid, poly-L-aspartic acid, poly-L-histidine, poly-L-ornithine, poly-L-serine, poly-L-threonine, poly-L-tyrosine, poly-L-leucine, poly-L-lysine-L-phenylalanine, poly-L-lysine or poly-L-lysine-L-tyrosine.
In yet another embodiment, the linking group or linker is of the formula W-(CHZ)õ wherein, n is between about 1 and about 10; and W is -N(R)C(=O)-, -C(=O)N(R)-, -OC(=O)-, -C(=O)O-, -0-, -S-, -S(O)-, -S(O)2 1 -C(=O)-, -N(R)-, or a direct bond; wherein each R is independently H or (C,-C6)alkyl. In yet another embodiment, the linking group or linker is methylene, ethylene, or propylene.
In still another embodiment, the linking group or linker is attached to the phosphonate group through a carbon atom of the linker.
In one aspect, the compounds of this invention can be linked to one or more phosphonate groups capable of providing tissue or cell selection to the compounds, e.g., capable of directing the compounds to desired target tissue(s) or cell(s), especially tissues or cells associated with infections or inflammations including without any limitation white blood cells.
In another aspect, the compounds of this invention can be linked to one or more phosphonate groups capable of inducing or triggering an enzymatic activation, e.g., one or more in vivo enzymatic cleavages or modifications which could result in an intracellular accumulation of the cleaved or modified compounds. For example, the phosphonate group of the compounds of this invention may cleave in vivo in stages after they have reached the desired site of action, e.g., inside a cell. One mechanism of action inside a cell may entail a first cleavage, e.g., by esterase, to provide a negatively-charged "locked-in"
intermediate. Cleavage of a terminal ester grouping in a compound of the invention thus affords an unstable intermediate which releases a negatively charged "locked in" intermediate. After passage inside a cell, intracellular enzymatic cleavage or modification of the phosphonate or prodrug compound may result in an intracellular accumulation of the cleaved or modified compound by a "trapping" mechanism. The cleaved or modified compound may then be "locked-in" the cell by a significant change in charge, polarity, or other physical property change which decreases the rate at which the cleaved or modified compound can exit the cell, relative to the rate at which it entered as the phosphonate prodrug. Other mechanisms by which a therapeutic effect is achieved may be operative as well. In general, enzymes capable of an enzymatic activation mechanism with the phosphonate prodrug compounds of the invention include, but are not limited to; amidases, esterases, microbial enzymes, phospholipases, cholinesterases, and phosphatases.
In one particular aspect, the compounds of this invention can be linked with one or more groups A ; or a pharmaceutically acceptable salt thereof, wherein:

A is A', A2 or W3;
A'is:

~
l R2 R2 M12a M12b AZ is:

M12a M12b A3 is:

Yi Yi Y2 2 P R"

M r12a M2 2 M 12b =

Y' is independently 0, S, N(Rx), N(O)(Rx), N(ORx), N(O)(ORx), or N(N(RX)( R'));

Y2 is independently a bond, 0, N(R'), N(O)(RX), N(ORX), N(O)(ORx), N(N(R')( R")). -S(O)MZ , or -S(O)MZ S(O)MZ ;
Rx is independently H, R', W3, a protecting- group, or the formula:
Y1 Ry Ry Yi eo~~ Y2 Y2 Y2 " Ry M12c M1c M1d M1a wherein:
R'' is independently H, W3, RZ or a protecting group;
R' is independently H or alkyl of 1 to 18 carbon atoms;
R2 is independently H, R', R3 or R wherein each R" is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to R3 groups;
R3 is R3a, R' or R, provided that when R3 is bound to a heteroatom, then R3 is R3` or Rm;
R' is F, Cl, Br, I, -CN, N3 or -NO2;
R3b is Y';
R' is -R", -N(R")(R"), -SR", -S(O)R", -S(O)ZR", -S(O)(OR"), -S(O)z(OR`), -OC(Y')Rx, -OC(Y')ORx, -OC(Y')(N(RX)(RX)), -SC(Y')Rx, -SC(Y')ORx; -SC(Y')(N(Rx)(Rx)), -N(Rx)C(Y')Rx, -N(Rx)C(Y')ORx, or -N(RY)C(Y')(N(R")(Rs)) ;
R"d is -C(Y')R", -C(Y')OR" or -C(Y')(N(Rx)(R));
R' is an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms;
RS is R wherein each R4 is substituted with 0 to 3 R' groups;
R' is independently alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2-18 carbon atoms any one of which alkylene, alkenylene or alkynylene is substituted with 0-3 R3 groups;
W3 is W4 or W5;

W4 is R5, -C(Y')R5, -C(Y')W5, -SO.ZRS, or -SOWS;

WS is carbocycle or heterocycle wherein WS is independently substituted with 0 to 3 Rz groups;

W is W3 independently substituted with 1, 2, or 3 A3 groups;
M2is0,1or2;
M12ais1,2,3,4,5,6,7,8,9,10,11or12;
M12b is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12;
M1a, M1c, and M1d are independently 0 or 1; and M12c is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12.
In one specific embodiment, A' is of the formula:

M12a M12b In another specific embodiment A' is of the formula:

2 Y? A3 M12a M12b - In another specific embodiment A' is of the formula:

Ws M12a M12b In another specific embodiment A' is of the formula:

M12a In another specific embodiment A' is of the formula:
5a \A3 M12a and W' is a carbocycle or a heterocycle where W' is independently substituted with 0 or 1 R 2 groups. A specific value for M12a is 1.
In another specific embodiment A' is of the formula:

M12a M 12b In another specific embodiment A' is of the formula:

\

M12a =

In another specific embodiment A' is of the formula:
w5a wherein W' is a carbocycle independently substituted with 0 or 1 R 2 groups;
In another specific embodiment A' is of the formula:

I I
~Ry --~Y Y2b ~ \ I H-1. O

M 12d wherein Y2'' is 0 or N(RZ); and M12d is 1, 2, 3, 4, 5, 6, 7 or 8.
In another specific embodiment A' is of the formula:
W5a M 12a =

wherein W is a carbocycle independently substituted with 0 or 1 RZ groups;
In another specific embodiment A' is of the formula:
W5a A

' .
wherein W5a is a carbocycle or heterocycle where WS' is independently substituted with 0 or 1 R 2 groups.
In another specific embodiment A' is of the formula:

0-1 y -~Y Y2b R

H H I,-,' w3 O
y 2b M12d wherein Y'b is O or N(RZ); and M12d is 1, 2, 3, 4, 5, 6, 7 or 8.
In yet another specific embodiment A 2 is of the formula:

T2R R?

M12a M12b In another specific embodiment A2 is of the formula:

M 12a M12b.

In another specific embodiment M12b is 1.
In another specific embodiment M12b is 0, YZ is a bond and WS is a carbocycle or heterocycle where WS is optionally and independently substituted with 1, 2, or 3 RZ groups.
In another specific embodiment AZ is of the formula:
W5a M12a :
wherein W5* is a carbocycle or heterocycle where WI" is optionally and independently substituted with 1, 2, or 3 R2 groups.
In another specific embodiment M12a is 1.
In another specific embodiment AZ is selected from phenyl, substituted phenyl, benzyl, substituted benzyl, pyridyl and substituted pyridyl.
In another specific embodiment AZ is of the formula:

M12a M 12b In another specific embodiment AZ is of the formula:
Y2 wa M12a M 12b In another specific embodiment M12b is 1.
In yet another specific embodiment A' is of the formula:
Y

pl-I RX

Y

M12a M12b In another specific embodiment A3 is of the formula:

Y

Y Y2 Rx TR R2 M 12a In another specific embodiment A3 is of the formula:
Y1a Y2a Rx TR 2 M 12a wherein Y'a is 0 or S; and Y' is 0, N(Rx) or S.
In another specific embodiment A3 is of the formula:
O
. II
Rx Y2b RIR 2 M12a wherein Y2b is 0 or N(RX).
In another specific embodiment A; is of the formula:

O
11 Rx Y2 b R~. R~

M12d .
wherein YZb is 0 or N(Rx); and M12d is 1, 2, 3, 4, 5, 6, 7 or 8_ In another specific embodiment A3 is of the formula:
O
. II
Rx ~ Y2b H H

M12d wherein YZb is 0 or N(RX); and M12d is 1, 2, 3, 4, 5, 6, 7 or 8.
In another specific embodiment M12d is 1.
In another specific embodiment A3 is of the formula:
Y2 Rx ~,2W 3 M12a M12b In another specific embodiment A3 is of the formula:

Yi Y2 IP Rx 5. M12b In another specific embodiment WS is a carbocycle.
In another specific embodiment A3 is of the formula:

lY1 Y2 (P Rx N/ 1-1 Rx M12a 0 M12b In another specific embodiment WS is phenyl.
In another specific embodiment A3 is of the formula:
yla Y2a Rx / y2a Z
R2 R2 Ws M12a y2a wherein Y" is 0 or S; and Y''a is 0, N(R") or S.
In another specific embodiment A3 is of the formula:

O
I I
Rx Y2 b Y2b M 12a =
, wherein Y' is 0 or N(Rx).
In another specific embodiment A3 is of the formula:
O
. ~~
RX
p Y2 ~

R~ R~
/w 3 M 12d y2b wherein Y2b is 0 or N(Rx); and M12d is 1, 2, 3, 4, 5, 6, 7 or 8.
In another specific embodiment R' is H.
In another specific embodiment A3 is of the formula:

0 R' \Y2b ~
M12d OR
R R

wherein the phenyl carbocycle is substituted with 0, 1, 2, or 3 RZ groups.
In another specific embodiment A3 is of the formula:

~~/O R~
P
M 12d H N --Ir OR~

In another specific embodiment A3 is of the formula:

Z~ P

\H OR' H H

In another specific embodiment A' is of the formula:
. ~

( /

\\ O CH3 1~0 P
OR
H H
O
In another specific embodiment A3 is of the formula:

O O

0 \\~ P R2 l O O O
H H

In another specific embodiment A3 is of the formula:

yla R2 Y2a II Y\
Y2a Ry Yi M12a wherein Y" is 0 or S; and YZ' is 0, N(R2) or S.
In another specific embodiment A' is of the formula:

\
Ry ~ Y2b Yla M12a wherein Y' is 0 or S; Y' is 0 or N(RZ); and Y' is 0, N(R'') or S.
In another specific embodiment A3 is of the formula:

R W W

+Y2b(RY1a M12d wheren Y'a is 0 or S; Yb is 0 or N(RZ); Yd is 0 or N(R''); and M12d is 1, 2, 3, 4, 5, 6, 7 or 8.
In another specific embodiment A3 is of the formula:
.O R2 I I

Y2b Ry H H

M12d wherein Y'b is 0 or N(R 2); and M12d is 1, 2, 3, 4, 5, 6, 7 or 8.
In another specific embodiment A3 is of the formula:

II --"y Y2b 0. R2 O
H H

wherein Y' is 0 or N(R).
In another specific embodiment A3 is of the formula:

II

\\~~ O
/o P II 0`R2 12.

In another specific embodiment A3 is of the formula:
Yi l,2 Rx Y2~
M12a In another specific embodiment A3 is of the formula:
y la R2 Y2a P Y~
RY
y 2a Yi ~
/
M 12a y 2a =
.
wherein Y" is 0 or S; and Y' is 0, N(R 2) or S.
In another specific embodiment A3 is of the formula:

Y
\

b Y1a 2b M12a ;
wherein Y" is 0 or S; Y'b is 0 or N(RZ); and Y' is 0, N(R'') or S.

In another specific embodiment A3 is of the formula:

I I 2d Ry Yta R~ R~ Y2b Y2b M 12d whereinY'aisOorS;Y2b isOorN(RZ);Y2d isOorN(R);andM12dis1,2,3,4,5, 6,7or8. 10 In another specific embodiment A3 is of the formula:

II

Y2b ` Ry O

M12d Y2b wherein Y2bis 0 or N(RZ); and M12d is 1, 2, 3, 4, 5, 6, 7 or 8.
In another specific embodiment*A3 is of the formula:

\Y2b R
---jy O
H ;= H W3 Y2b wherein Y2" is 0 or N(R 2).
In another specific embodiment A3 is of the formula:

2b IP
Y R"

M 12d \y2 b wherein: Y'b is 0 or N(R'); and M12d is 1, 2, 3, 4, 5, 6, 7 or 8.
In another specific embodiment A3 is of the formula:
\ ~

~ 1 ~P/O R
zb Y OR' R RW M12d O
wherein the phenyl carbocycle is substituted with 0, 1, 2, or 3 R2 groups.
In another specific embodiment A3 is of the forinula:

\
~

~P/O R

O OR
R1 wM12d O
wherein the phenyl carbocycle is substituted with 0, 1, 2, or 3 RZ groups.
In another specific embodiment A3 is of the formula:

Me Me O
j OR.1 H H

In yet another specific embodiment A is of the formula:

ii O R
j-(CH2)f.10 R
wherein each R is independently (C,-Cb)alkyl.
In yet another specific embodiment R` is independently H, R', W3, a protecting group, or the formula:

Yi Ry Rv Yi Ry 'J~ Y2 lr2 Y2 M12c M1c M1d M1a wherein:
Ry is independently H, W3, R2 or a protecting group;
R' is independently H or alkyl of 1 to 18 carbon atoms;
R2 is independently H, R', R3 or R` wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to R3 groups;
In yet another specific embodiment R" is of the formula:

Y2c Ry Y~a , wherein Y'H is 0 or S; and Y' is 0, N(R'') or S.
In yet another specific embodiment Rx is of the formula:

Y2d Ry 1. .

Y1a wherein Y'a is 0 or S; and YZd is 0 or N(R'').
In yet another specific embodiment RX is of the formula:

Ry In yet another specific embodiment Ry is hydrogen or alkyl of 1 to 10 carbons.
In yet another specific embodiment RX is of the formula:

O'1~ R2 O
In yet another specific embodiment Rx is of the formula:

Ry --~ Y2"
M12a In yet another specific embodiment Rx is of the formula:

1 ~ Ry M 12a Y1 In yet another specific embodiment Y' is 0 or S
In yet another specific embodiment YZ is 0, N(R'') or S.
In yet another specific embodiment Rx is a group of the formula:
Y1 [Rk Ry Yi Ry y 2 )- - y 2 y 2 M1a M1b M12c M1c M1d M1e wherein:
mla, mlb, mlc, m1d and m1e are independently 0 or 1;
ml2c is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12;

RY is H, W3, R 2 or a protecting group;
provided that:
if mla, ml2c, and m1d are 0, then mlb, mlc and m1e are 0;
ifmlaandml2care0andmldisnot0,thenmibandmlcare0;
if mla and mld are 0 and m12c is not 0, then mlb and at least one of m1c and mie are 0;
if mla is 0 and m12c and mld are not 0, then mlb is 0;

if m12c and m1d are 0 and m1a is not 0, then at least two of m1b, m1c and m1e are 0;
if m12c is 0 and mla and mld are not 0, then at least one of mlb and mlc are 0; and if mld is 0 and mia and m12c are not 0, then at least one of mlc and m1e are 0.
In yet another specific embodiment, the phosphonate prodrug compound of this invention has the formula:

[DRUG]-(A )nn or a pharmaceutically acceptable salt thereof wherein, DRUG is a compound of this invention nn is 1, 2, or 3;
A is A', A 2 or W' with the proviso that the compound includes at least one A';
A' is:

Ws M12a M12b A'is:

M12a M12b A3 is:

Y1 Yi YZ P P Rx l Y2 Y2 Y2 R2 R2 Rx M2 M12a 2 M12b Y' is independently 0, S, N(Rx), N(O)(Rx); N(OR'), N(O)(ORx), or N(N(R")( Rx));
YZ is independently a bond, 0, N(R'), N(O)(Rx), N(ORX), N(O)(ORx), N(N(Rx)( Rx)), -S(O)N,2-, or -S(O)MZ S(O)MZ ;
R" is independently H, R', W3, a protecting group, or the formula:
Yi Rr Rv YI

RY
Y Y2 Y2 -y- - -M12c M1c M1d M1a wherein:
R'' is independently H, W3, RZ or a protecting group;
R' is independently H or alkyl of 1 to 18 carbon atoms;
R2 is independently H, R', R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R 2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to R' groups;
R3 is R'3, R3b, R3` or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3` or R3d;
R3a is F, Cl, Br, I, -CN, N3 or -NOZ;
R3b is Y';

R3` is -R", -N(Rx)(Rx), -SRx, -S(O)RX, -S(O)ZRx, -S(O)(ORX), -S(O)2(ORx), -OC(Y')R', -OC(Y')OR', -OC(Y')(N(RX)(Rx)), -SC(Y')Rx, -SC(Y')ORx, -SC(Y')(N(Rx)(RX)), -N(R')C(Y')Rx, -N(Rx)C(Y')ORx, or -N(Rx)C(Y')(N(Rx)(R)) ;
R3d is -C(Y')Rx, -C(Y')ORX or -C(Y')(N(R')(Rx));

R' is an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms;
R5 is R' wherein each R4 is substituted with 0 to 3 R3 groups;
R' is independeritly alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2-18 carbon atoms any one of which alkylene, alkenylene or alkynylene is substituted with 0-3 R3 groups;
W31S W or W5;
W4 is R5, -C(Y')R5, -C(Y')W5, -SOZRS, or -SOZWS;

W5 is carbocycle or heterocycle wherein WS is independently substituted with 0 to 3 R2 groups;

W is W3 independently substituted with 1, 2, or 3 A' groups;
M2 is 0,1 or 2;
M12ais1,2,3,4,5,6,7,8,9,10,i1or12;
M12b is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12;
M1a, Mlc, and Mld are independently 0 or 1;
M12c is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12;
X' is hydrogen or fluorine; and X67 is hydrogen, hydroxy, or acyloxy.
In yet another specific embodiment, the phosphonate prodrug compound of this invention has the formula:
[DRUG]-[L-P(=Y' )-YZ-Rx]nn or a pharmaceutically acceptable salt thereof wherein, DRUG is a compound of this invention;
Y' is independently 0, S, N(RX), N(O)(RX), N(OR'), N(O)(ORX), or N(N(R')( Rx));
y2 is independently a bond, 0, N(R"), N(O)(RX), N(ORX), N(O)(OR'), N(N(Rx)( RX)), -S(O)ti,Z , or -S(O)MZ-S(O)M, %
R' is independently H, W', a protecting group, or the formula:

Y1 Ry Ry Yi Ry "'~y2-_ Y2 Y2 .
M12c M1c M1d M1a R'' is independently H, W3, RZ or a protecting group;
R2 is independently H, R' or R' wherein each R4 is independently substituted with 0 to 3 R3 groups;
R3 is R-33, R3b, R" or R3d, provided that when R3 is bound to a heteroatom, then R3 is R~ or R3d;
R3a is F, Cl, Br, I, -CN, N3 or -NO
R3b is Y;
R' is -R", -N(R")(R"), -SR", -S(O)R", -S(O)ZR", -S(O)(OR"), -S(O)Z(OR"), -OC(Y')Rx, -OC(Y')OR", -OC(Y')(N(Rx)(RX)), -SC(Y')Rx, -SC(Y')ORx, -SC(Y')(N(Rx)(Rx)), -N(RX)C(Y')Rx, -N(Rx)C(Y')ORx, or -N(RX)C(Y')(N(RX)(RX)) ;
R~ is -C(Y')Rx, -C(Y')OR" or -C(Y')(N(R )(Rx));
R' is an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms;
R5 is R4 wherein each R" is substituted with 0 to 3 R3 groups;
W31S W4 or W5;
W4 is R5, -C(Y')R5, -C(Y')W5, -SO2R5, or -SOZWS;

W5 is carbocycle or heterocycle wherein W5 is independently substituted with 0 to 3 RZ groups;
M2is1,2,or3;
Mia, M1c, and Mld are independently 0 or 1;
M12c is 0, 1, 2,3,4,5,6,7,8,9, 10, 11 or 12;
X' is hydrogen or fluorine; and ?C67 is hydrogen, hydroxy; or acyloxy;
nn is 1, 2, or 3; and L is a linking group.

In another specific embodiment, the phosphonate prodrug compound of this invention has the formula:

[DRUG]-(A ) or a pharmaceutically acceptable salt thereof wherein, DRUG is a compound of this invention;

nn is 1, 2, or 3;
A is A', A2, or W3 with the proviso that the compound includes at least one A';
A'is:

M12b A 2 is:

2 Y\
w3 tM12 M12b A' ls:

M12a 2 M12b Y' is independently 0, S, N(Rx), N(O)(RX), N(ORx), N(O)(ORx), or N(N(Rx)( Rx));
YZ is independently a bond, O, N(RX), N(O)(R"), N(OR"), N(O)(OR'), N(N(R")( Rx)), -S(O),,Z , or -S(O)MZ S(O)M2 ;

R" is independently H, W', a protecting group, or the formula:

YI Ry Ry Y1 Ry t M12c M1c M1d M1a R'' is independently H, W3, R2 or a protecting group;
RZ is independently H, R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups;
R3 is R3a, R3b, R3` or R'd, provided that when R3 is bound to a heteroatom, then R3 is R'` or R3d;
R3a is F, Cl, Br, I, -CN, N3 or -NOZ;
0 is Y';
R' is -R", -N(R")(R"), -SR", -S(O)R", -S(O)ZR", -S(O)(OR"), -S(O)Z(OR"), -OC(Y')Rx, -OC(Y')ORx, -OC(Y')(N(RX)(Rx)), -SC(Y')Rx, -SC(Y')ORX, -SC(Y')(N(Rx)(Rx)), -N(Rx)C(Y')R , -N(R")C(Y')ORx, or -N(RX)C(Y')(N(RX)(Rx)) ;
R~ is -C(Y')Rz, -C(Y')ORx or -C(Y')(N(Rz)(Rx));
R" is an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms;
groups;
R5 is R4 wherein each R4 is substituted with 0 to 3 R3 W'isW orW5;
W4 is R5, -C(Y')R5, -C(Y')W5, -SOZRS, or -SOZWs;

WS is carbocycle or heterocycle wherein WS is independently substituted with 0 to 3 R2 groups;
W6 is W3 independently substituted with 1, 2, or 3 A3 groups;
M2 is 0, 1 or 2;
M12a is 1, 2,3,4,5,6,7,8,9, 10, 11 or 12;
M12bis0,1,2,3,4,5,6,7,8,9,10,11or12;
M1a, Mlc, and M1d are independently 0 or 1;
M12c is 0, 1, 2,3,4,5,6,7,8,9, 10, 11 or 12;
X' is hydrogen or fluorine; and X67 is hydrogen, hydroxy, or acyloxy.
In one specific embodiment X61 is methoxy, ethoxy, n-propoxy, difluoromethoxy, trifluoromethoxy, ethyl, methyl, propyl, or n-butyl) In phosphonate prodrug compounds of this invention, W5 carbocycles and WS heterocycles may be independently substituted with 0 to 3 RZ groups. WS
may be a saturated, unsaturated or aromatic ring comprising a mono- or bicyclic carbocycle or heterocycle. WS may have 3 to 10 ring atoms, e.g., 3 to 7 ring atoms. The WS rings are saturated when containing 3 ring atoms, saturated or mono-unsaturated when containing 4 ring atoms, saturated, or mond- or di-unsaturated when containing 5 ring atoms, and saturated, mono- or di-unsaturated, or aromatic when containing 6 ring atoms.
A WS heterocycle may be a monocycle having 3 to 7 ring members (2 to 6 carbon atoms and 1 to 3 heteroatoms selected from N, 0, P, and S) or a bicycle having 7 to 10 ring members (4 to 9 carbon atoms and 1 to 3 heteroatoms selected from N, 0, P, and S). WS heterocyclic monocycles may have 3 to 6 ring atoms (2 to 5 carbon atoms and 1 to 2 heteroatoms selected from N, 0, and S);
or 5 or 6 ring atoms (3 to 5 carbon atoms and 1 to 2 heteroatoms selected from N
and S). WS heterocyclic bicycles have 7 to 10 ring atoms (6 to 9 carbon atoms and 1 to 2 heteroatoms selected from N, 0, and S) arranged as a bicyclo [4,5], [5,5], [5,6], or [6,6] system; or 9 to 10 ring atoms (8 to 9 carbon atoms and 1 to 2 hetero atoms selected from N and S) arranged as a bicyclo [5,6] or [6,6] system. The WS
heterocycle may.be bonded to Y2 through a carbon, nitrogen, sulfur or other atom by a stable covalent bond.
WS heterocycles include for example, pyridyl, dihydropyridyl isomers, piperidine, pyridazinyl, pyrimidinyl, pyrazinyl, s-triazinyl, oxazolyl, imidazolyl, thiazolyl, isoxazolyl, pyrazolyl, isothiazolyl, furanyl, thiofuranyl, thienyl, and pyrrolyl. WS also includes, but is not limited to, examples such as:

N
N N
. N. ~
~
N H

N
S~ N\~
S and S

WS carbocycles and heterocycles may be independently substituted with 0 to 3 RZ groups, as defined above. For example, substituted WS carbocycles include:
OH

CI
N

l 1 H

CI

N

~ \ NH l NH l-N NH
- O 1 ~ SH 1-N S02 Examples of substituted phenyl carbocycles include:

HN HN O
~-NH2 ~-NMe2 _~-NH2 -O ~NH
O O ~ -O

NH2 ~ ~ ~NHZ
O
1 ~ ~

Additional phosphonate groups are disclosed in U.S. patent application U.S. Publication No. 2004100960, the entirety of which is incorporated herein by reference. One skilled in the art will recognize that substituents and other moieties of the compounds under the present Phosphonate Prodrug Compound section of this application should be selected in order to provide a compound which is sufficiently stable, bioavailable, and suitable for providing a pharmaceutically useful compound which has a minimum level of biological activity and can be formulated into an acceptably stable and suitable pharmaceutical composition.

By way of example and not limitation, phosphonate prodrug embodiments of the invention are named below in tabular format (Table 7).
These embodiments- are of the general formula "MBF":
O
II
ScLg Pd2 Pdl MBF
Each embodiment of MBF is depicted as a substituted nucleus (Sc). Sc is described in formulae 1-14 of Table 1.1 herein, wherein Sc is a generic formula for a compound of Formula I, A is the point of covalent attachment of Sc to Lg, nn designates the number of -Lg-P(O)Pd'Pd2 groups attached to Sc, and T1A, T2A, XlA, X2A, etc. and the terms "Alk", "Ar", and "Het" are as defined above (e.g., in Tables 1-5, and the text preceeding Tables 1-5).
For those embodiments described in Table 7, Sc is a nucleus designated by a number, and each substituent is designated in order by letter or number.
Table 1.1 is a schedule of nuclei used in forming the embodiments of Table 7.
Each nucleus (Sc) is given a number designation from Table 1.1, and this designation appears first in each embodiment name. Similarly, Tables 10.1 to 10.19 and 20.1 to 20.37 list the selected linking groups (Lg) and prodrug (Pd' and PdZ) substituents, again by letter or number designation, respectively.
Accordingly, a compound of the formula MBF includes compounds having Sc groups based on formula 1-14 herein as well as compounds according to Table 7 below. In all cases, compounds of the formula MBF have groups Lg, Pd' and PdZ
set forth in the Tables below.
Accordingly, each named embodiment of Table 7 is depicted by a number designating the nucleus from Table 1.1, followed by a letter designating the ' linking group (Lg) from Table 10.1-10.19, and two numbers designating the two prodrug groups (Pd' and Pd2) from Table 20.1-20.36. In graphical tabular form, each embodiment of Table 100 appears as a name having the syntax:

Sc.Lg.Pd'.Pd2 Q' and Q2 of the linking groups (Lg), it should be understood, do not represent groups or atoms but are simply connectivity designations. Q' is the site of the covalent bond to the nucleus (Sc) and QZ is the site of the covalent bond.to the phosphorous atom of formula MBF. Each prodrug group (Pd' and PdZ) are covalently bonded to the phosphorous atom of MBF at the A symbol.
Some embodiments of Tables 10.1-10.19 and 20.1-20.36 may be designated as a combination of letters and numbers (Table 10.1-10.19) or number and letter (Table 20.1-20.36). For example there are Table 10 entries for BJl and BJ2. In any event, entries of Table 10.1-10.19 always begin with a letter and those of Table 20.1-20.36 always begin with a number. When a nucleus (Sc) is shown enclosed within square brackets ("[]") and a covalent bond extends outside the brackets, the point of covalent attachment of Sc to Lg may be at any substitutable site on Sc. Selection of the point of attachment is described herein. By way of example.
and not limitation, the point of attachment is selected from those depicted in the schemes and examples.
Table 1.1 OH \~ Ik O X2D
T16 NH N~ ~ H OH i Ik O

0 AIk (AO)nn T1A N NT26 0 Alk \
(AO)nn xic (AO)nn /
X2A X2B~
H OH \i Ik O OH i Ik O
T1 B N N~ ~ ~
~ H T2B T1C N N N~T2A-(AO)nn H
O AIk~ 0 Alk~

. , (AO)nn /

O O X2A~AIk T1 B H N~ ~S H OH ~ O\ O
N N~N~S"
~ H T2D T1CT H

O AIk ~X1A-(AO)nn AIk,, X1 E

X2A X2C OH \AIk H OH 0\ ~O H OH O
(AO)nn-T1Ay N N" N~Sl~ T2C T16~N N~N"SI T2B
H H
0 AIk,_ 0 AIk~
X1 F X1A-(AO)nn (Ao)nn X2F X2F~
OH AIk 0 OH Alk O
H I ll T1C N N'N"S'~T2D (Ao)nn T1A N N~S~T2F
T Alk 0 Alk ", X1 D XIB

X2C~ (Ao)nn H AIk O /

T1 ByN N T2B N OH N ~Alk O
O ~Alk Alk T1 B -_~y ~N~T2B
X1A y H
0 AIk Alk (Ao)nn X1 C~

. .
X2D'-AIk O OH B\Alk 0 H OH I H I --T---,Y (Ao) -T1A N N T1C N -1-Y N, nn ~ ~N T2B ~ H T2A-(Ao)nn H
0 AIk AIk 01D~AIk Alk X 1 C~
'5 Table 10.1 R5a Q2 QI Q2 Q\ /Q2 A B C
Q1\ Q2 Q1 R5a Q ~Y
W5a Y2 ~Q2 R5a Q2 D E F
1 5a 5a Q~ Y2 Q~ R
Y2W~Q2 W~ '-"Q2 W5a Q2 Q1 Wg\ Q2 ~
5a Q1 W5a ~ R5a R5a Q R~ WQ2 W5a ~Q2 L
~ K

Q~ 5a ~W5a R5a YR5a Q
R

M Q~ R5a ~ Y2 Q
N

Q1 /c? Q1 ~2 R5a Ql\Y2/Q2 A B C

Wya ~\ y2 RS~01 R5a YQ2 D E F
W5a Ql /Y2 QZ` a R5 Y2~ ~ \W5a c? W5 G H I

a y~Je W5~ . ~~ R5a ~~ R5a R5a Q2 w5a Q2 L
K

Ql W5a /Qz Qi /1' 2 R5a W{a R5a R5a /~~ /~
M R5a Y2 0 N
Table 10.2 R5a Q2 ~\R5a Y~~a ~ ~a \Y2/
Ql R5a /0, P W5a W5a R
Q
~a ~'R5a ~ QWsa YR5a ~

~a ~Y2/~
S U
T
~21\~a Y~T=~aQ2 Ql\YZR5Y2 VVV R5a /Q2 `I O~\Y2~ W5a X

w ~ W5 YZR5a Y2y2/Q2 Y Y2/~\yV'a AA
Z

Table 10.3 Qi 01 AB AC CK AD

(21 Q~ Q' AE
AF

Q

Q2 Q1 ~
C~
Al AG pH

21~ Q2 ~ \ Q2 AK
AJ

~\ Q2 Ql` QZ
~
AM
AL

Table 10.4 4\

H AN H AO
AP
Q~
N"'~y H AQ

AR

CH

~
~

H AS ( ~.l AV
CH

((Q2 4 Qc~

R AY
AX

Table 10.5 ol o o ~
~ BA
Q2 Q~3 Q2 Ql B B

BC Q2 0~~~
Ql B D
Ql oQz Qz ~ O BF

O
O Qi B H

O
H3C Q, CH3 B]1 Table 10.6 BK
O

BL
~
~

BM

BO

Table 10.7 Q1~~0 BQ

Ql Q1 Ql O

BT

BU ~

~ 01 O

Table 10.8 071~ CI-13 Cl-I

BY

O Y'*'BZ C.H3 H3C C~

CA

O

Table 10.9 Ql O (22 CH3 C, 3 CE

CF `--H3 H3C C~

CG

' ~ CH
`-Table 10.10 I = ~ .
Q\/N (~ N
N Qz ~ Q2 ~ YCJ Q2 H

cm Ql ~ =

H Q2 Q\/N
I Ql N CO

= N
Qi CQ

CR
~ Q1 c CT cs Table 10.11 H

H
CU I
Ql Qi N
CV

cw ( H
H I
N =
Ol IX

H
3C Ol CY

CH3 H cz Table 10.12 Q~ Q1 N

DA
~ DB
Ql Q2 DC I
CH~
DD

~ 02 I

cl-13 DF

Table 10.13 H
H
Q~ Qi N .
DG

DH
DI

H
.. I .
1-13C C113 DJ cH3 DK
H

Q1 ~

H DL
~

Table 10.14 H
H

CH3 Cl-4 cFb DN
(~2 DO I
H
H
i Q~

Cl 3 QZ
DQ H

~ 01 H DR
~

Table 10.15 I I
N
DS DT
QZ 3 CH3 Q2 ~ R3 DU
R

I ~ N H3C

DV

i3 DW
~~ .

DX
R3 Q2 Q \/ N
Ql N DY

C~ DZ

EB

EC

ED

Table 10.16 I
N

EE I

EF

~ EH q Table 10.17 EK
cii3 EL

EM i3 CH3 EN

EO I 3 cfl~
Q' EP

Table 10.18 Q1l~

EQ

CF~3 ER
Q1 `

R

H3 ~ ET ~

Q1 "

EU i3 ~ ~ .

Table 10.19 Ql~~ N Q2 Cli3 EX

H3C C~ N)- 01 (~j C~
s FB

Table 20.1 ON-1 O\5 W3 0-1~y R
O O

R Rl 0- O . ..

?\ 0-----p O

~\

O

pCH3 O

O

Table 20.2 ~~ O CH3 .
O

p QH3 O
-00"'y Zo o ~

r~ o o e%

Table 20.3 CI-13 c", O W

O O

(:ti3 o\ 4 - 1 O R R
~
_~y r~ O

ci-~3 O

Table 20_4 O Cl' r~ o CH3 cit C. H

1~ o Table 20.5 pIN" O\
j/N3 R5 23 1_13C 24 p\ R4 p\ R1 p 0 H p CH3 o cH3 H3c p~ 0 O

Table 20.6 FIc O

o CH3 CH

"~O CH3 O

Table 20.7 O ~W3 0--l-0 ~1-1 R5 O O

~\ Q\
R4 O\ R1 p . O

O Q~-W 3 K-1, O 0*1_1 R5 O O

0-1, 4 O~ 1 --Iy O R O R
Q O

Table 20.8 W3 \0 --Iy C3- y O

O\ O~ 1 O O

R1 Ri ej-," --Iy O--,,3 O 0-11 R5 O W

O ' O

O R 4 Rl O O

Table 20.9 0 ',~W3 \ R5 N--"~y p p R4 N-*'~y Rl N"'~y I O O

52 53 N"'~y H

H O H O

. ~~
Cit H O

N'-~y H O

Table 20.10 ~~ o cH3 H O

~~ O I 0-13 O

Table 20.11 CF' 0 11-~W3 N----y 0 "1-, Rs f o I o Cit Cft R4 Ri N----"Y I 0 I O

0-1~ Cl-]6 W--'y ON--'y H

H O H O

O N---- 'y ~ O-I~
H O-ti---,, 0~~CI-13 N---'y H 0 Table 20.12 1~ o H3 I o C113 N--Iy CH3 H O

Table 20.13 ON~ O~

R4 Ri i 0 I 0 F4C 74 jj3C 75 O~
I H ~

H y H 0 O
N---'y Cl-f3 O\/CH3 78 .

Table 20.14 O Q-~

yo CH3 I

~\ .

H O

Table 20.15 W3 W3 N----y I W ( R5 O--l 4 Ri N--'y R N----'y I p i 0 Q--,,3 N----'y R5 N----'y W

H O

R4 0-1, R1 N----'y LA 0 H O

Table 20.16 N----y I W ( H O

R 4 Rl 0-1, 0-11 5 N-----'y W3 R

I O

R' R1 O--, R' N---'y N---Iy H H 0 O

Table 20.17 0 "*~3 r--,,, O**-I R5 I W

4 N--~y O~Rl N'-~y I R

O\ 0-~,, N"*~y H I CI-4 p N--'*"*'y CH3 .106 O,~CH3 N-~~y I3 0 Table 20.18 R 108 0 CIi3 Table 20.19 ~ ~
O\ O\5 ~ CH3 "t y 0\ 1 ~\ Q\ 4 ` \
R R

~ Cl-13 x ~ ( R3 O R3 p ~

N---'y ~

Qcj-~3 Table 20.20 o CH3 ?--~
0",~r .

CF~3 CF13 Table 20.21 i3 0 R 0 H3c 121 122 R *4 O -11, Rl i3 0 I 0 1-13c 123 ~c 124 R3 O R. O

~c ~13 O

Table 20.22 O

3 p CI-4 R O

Table 20.23' 0 '~W3 0 -~R5 I . I

W3 w3 (lL(o R R

O-~I3 R5 W

JO\ R 4 0-1, Rl.
I I

Table 20.24 O 3 t N---'y O Rs N----'y I W

4 Rl N----'y I R

R1 R' 0--I3 N--Iy 0-1, R5 N----y W

ONI, 4 N---'y 1 N---'y R R

Table 20.25 ~\ 3 ~\

W

Rl H R3 151 152. 153 Wa R5 R4 R' H R3 Table 20.26 ~` W3 1\ R5 R4 N

I I H
H

Ri H R3 Table 20.27 R5\ R5\

R5\ R5 AR4 AR' R5\ H \~ R5 O ACI*

R5Z"o ci-4 0 R5a ~

Table 20.28 O

Rsa O Rs\ ~ O-Iy RsaO

R5a ~~o~ RS~o O
R 5a Table 20.29 O O
e~\ 3 O O W AR5 O O
~ ~ \O/\ R4 \~\ R1 O O
AH ~ CH3 O

cl-~ 0 ~
o~~o \O/~ ul~u . 193 Table 20.30 1\0 0 cll~

cl-13 196 0 r\O/\O

O

Table 20.31 R5a W3 0 o o R5a R5 O

RSa R4 0 R5a Rl O
R5a o H R5a CH3 \ A011-0 R5\

R5a \~ \ Ao-,-\CI-13 Table 20.32 O CEt R5a O
0 CEi3 208 1-1-1 R5~

0 c1% 209 R5a CH3 o o CI-13 ~ R5a cH3 o/ o 211 ~
R5a O
R5a \oi ~ o \

Table 20.33 OO O

O

O

O
O

Oo O"~Cx3 Table 20.34 222 t'---, O

\O/\O 0 t-) O

Table 20.35 R5a 0 --'3 R5a 0 ~ 5 W O R

/ R5a R5a O~

R5a O\ R5a O\
~ W3 ~ R5 I y I O

~ R5a r Rsa ~
\N/ R4 \~ Rl I

Table 20.36 R5a 0-1, R5a . 0--l' k3 0 I3 0 '~/ R5a ~ ~-R5a 0~
N R4 ~ R1 yI3 0 I3 0 I
\Io o ~

R

Table 20.37 p \ ~~ \

R3 . t .

Table 7 Prodrugs of 1.B
1.B.228.228; 1.B.228.229; 1.B.228.230; 1.B.228.231; 1.B.228.236; 1.B.228.237;
1.B.228.238; 1.B.228.239; 1.B.228.154; 1.B.228.157; 1.B.228.166; 1.B.228.169;
1.B.228.172; 1.B.228.175; 1.B.228.240; 1.B.228.244; 1.B.229.228; 1.B.229.229;
1.B.229.230; 1.B.229.231; 1.B.229.236; 1.B.229.237; 1.B.229.238; 1.B.229.239;
1.B.229.154; 1.B.229.157; 1.B.229.166; 1.B.229.169; 1.B.229.172; 1.B.229.175;
1.B.229.240; 1.B.229.244; 1.B.230.228; 1.B.230.229; 1.B.230.230; 1.B.230.231;
1.B.230.236; 1.B.230.237; 1.B.230.238; 1.B.230.239; 1.B.230.154; 1.B.230.157;
1.B.230.166; 1.B.230.169; 1.B.230.172; 1.B.230.175; 1.B.230.240; 1.B.230.244;
1.B.231.228; 1.B.231.229; 1.B.231.230; 1.B.231.231; 1.B.231.236; 1.B.231.237;
1.B.231.238; 1.B.231.239; 1.B.231.154; 1.B.231.157; 1.B.231.166; 1.B.231.169;
1.B.231.172; 1.B.231.175; 1.B.231.240; 1.B.231.244; 1.B.236.228; 1.B.236.229;
1.B.236.230; 1.B.236.231; 1.B.236.236; 1.B.236.237; 1.B.236.238; 1.B.236.239;
1.B.236.154; 1.B.236.157; 1.B.236.166; 1.B.236.169; 1.B.236.172; 1.B.236.175;
1.B.236.240; 1.B.236.244; 1.B.237.228; 1.B.237.229; 1.B.237.230; 1.B.237.231;
1.B.237.236;1.B.237.237; 1.B.237.238; 1.B.237.239; 1.B.237.154; 1.B.237.157;
1.B.237.166; 1.B.237.169; 1.B.237.172; 1.B.237.175; 1.B.237.240; 1.B.237.244;

1.B.238.228; 1.B.238.229;1.B.238.230;1.B.238.231;1.B.238.236; 1.B.238.237;
1.B.238.238; 1.B.238.239; 1.B.238.154; 1.B.238.157; 1.B.238.166; 1.B.238.169;
1.B.238.172;1.B.238.175;1.B.238.240;1.B.238.244;1.B.239.228; 1.B.239.229;
1.B.239.230; 1.B.239.231; 1.B.239.236; 1.B.239.237; 1.B.239.238; 1.B.239.239;
1.B.239.154;1.B.239.157;1.B.239.166;1.B.239.169;1.B.239.172; 1.B.239.175;
1.B.239.240; 1.B.239.244; 1.B.154.228; 1.B.154.229; 1.B.154.230; 1.B.154.231;
1.B.154.236; 1.B.154.237; 1.B.154.238;1.1ft154.239;1.B.154.154; 1.B.154.157;
1.B.154.166; 1.B.154.169; 1.B.154.172; 1.B.154.175; 1.B.154.240; 1.B.154.244;
1.B.157.228; 1.B.157.229;1.B.157.230; 1.B.157.231; 1.B.157.236; 1.B.157.237;
1.B.157.238; 1.B.157.239; 1.B.157.154; 1.B.157.157; 1.B.157.166; 1.B.157.169;
1.B.157.172; 1.B.157.175; 1.B.157.240; 1.B.157.244; 1.B.166.228; 1.B.166.229;
1.B.166.230; 1.B.166.231; 1.B.166.236; 1.B.166.237; 1.B.166.238; 1.B.166.239;
1.B.166.154; 1.B.166.157; 1.B.166.166;1.B.166.169;1.B.166.172; 1.B.166.175;
1.B.166.240; 1.B.166.244; 1.B.169.228; 1.B.169.229; 1.B.169.230; 1.B.169.231;
1.B.169.236; 1.B.169.237; 1.B.169.238; 1.B.169.239; I.B.169.154; 1.B.169.157;
1.B.169.166; 1.B.169.169; 1.B.169.172; 1.B.169.175; 1.B.169.240; 1.B.169.244;
1.B.172.228; 1.B.172.229; 1.B.172.230; 1.B.172.231; 1.B.172.236; 1.B.172.237;
1.B.172.238; 1.B.172.239; 1.B.172.154; 1.B.172.157; 1.B.172.166; 1.B.172.169;
1.B.172.172; 1.B.172.175; 1.B.172.240; 1.B.172.244; 1.B.175.228; 1.B.175.229;
1.B.175.230; 1.B.175_231; 1.B.175.236; 1.B.175.237; 1.B.175.238; 1.B.175.239;
.25 1.B.175.154; 1.B.175.157; 1.B.175.166; 1.B.175.169; 1.B.175.172;
1.B.175.175;
1.B.175.240; 1.B.175.244; 1.B.240.228; 1.B.240.229; 1.B.240.230; 1.B.240.231;
1.B.240.236; 1.B.240.237; 1.B.240.238; 1.B.240.239; 1.B.240.154; 1.B.240.157;
1.B.240.166; 1.B.240.169; 1.B.240.172; 1.B.240.175; 1.B.240.240; 1.B.240.244;
1.B.244.228; 1.B.244.229; 1.B.244.230; 1.B.244.231; 1.B.244.236; 1:B.244.237;
1.B.244.238; 1.B.244.239; 1.B.244.154; 1.B.244.157;1.B.244.166; 1.B.244.169;
1.B.244.172; 1.B.244.175; 1.B.244.240; 1.B.244.244;

Prodrugs of 1.D
1.D.228.228; 1.D.228.229; 1.D.228.230; 1.D.228.231; 1.D.228.236; 1.D.228.237;
.
1.D.228.238; 1.D.228.239; 1.D.228.154; 1.D.228.157; 1.D.228.166; 1.D.228.169;

1.D.228.172; 1.D.228.175;1.D.228.240; 1.D.228.244; 1.D.229.228; 1.D.229.229;
1.D.229.230; 1.D.229.231; 1.D.229.236; 1.D.229.237; 1.D.229.238; 1.D.229.239;
1.D.229.154; 1.D.229.157; 1.D.229.166; 1.D.229.169; 1.D.229.172; 1.D.229.175;
1.D.229.240;1.D.229.244;1.D.230.228; 1.D.230.229;1Ø230.230; 1Ø230.231;
1Ø230.236; 1Ø230.237; 1Ø230.238; 1Ø230.239; 1Ø230.154; 1Ø230.157;
1Ø230.166; 1.D.230.169;1Ø230.172; 1.D.230.175; 1.D.230.240;1Ø230.244;
1.D.231.228; 1.D.231.229; 1.D.231.230; 1Ø231.231; 1.D.231.236; 1Ø231.237;
1Ø231.238; 1Ø231.239; 1Ø231.154; 1Ø231.157; 1Ø231.166; 1Ø231.169;
1Ø231.172; 1.D.231.175; 1Ø231.240; 1Ø231.244; 1.D.236.228;1Ø236.229;
1Ø236.230; 1Ø236.231;1.D.236.236; 1.D.236.237; 1.D.236.238;1Ø236.239;
1.D.236.154; 1Ø236.157; 1Ø236.166; 1Ø236.169; 1.D.236.172; 1Ø236.175;
1Ø236.240; 1.D.236.244;1.D.237.228; 1.D.237.229; 1.D.237.230; 1Ø237.231;
1Ø237.236; 1Ø237.237; 1Ø237.238; 1Ø237.239; 1Ø237.154; 1.D.237.157;
1Ø237.166; 1Ø237.169;1Ø237.172; 1Ø237.175; 1.D.237.240; 1Ø237.244;
1.D.238.228; 1.D.238.229;1Ø238.230; 1Ø238.231; 1.D.238.236; 1.D.238.237;
1.D.238.238;1Ø238.239;1.D.238.154; 1Ø238.157; 1.D.238.166;1Ø238.169;
1Ø238.172; 1.D.238.175; 1.D.238.240; 1.D.238.244; 1.D.239.228; 1.D.239.229;
1Ø239.230; 1Ø239.231; 1Ø239.236; 1Ø239.237; l.D.239.238; 1Ø239.239;
1Ø239.154; 1Ø239.157; 1.D.239.166; 1Ø239.169; 1.D.239.172; 1.D.239.175;
1Ø239.240; 1Ø239.244; 1Ø154.228; 1Ø154.229; 1.D.154.230; 1Ø154.231;
1Ø154.236; 1Ø154.237; 1Ø154.238; 1Ø154.239; 1Ø154.154; 1Ø154.157;
1Ø154.166; 1Ø154.169; 1Ø154.172; 1Ø154.175; 1Ø154.240; 1.D.154.244;
1Ø157.228; 1Ø157.229; 1Ø157.230; 1Ø157.231; 1.D.157.236; 1Ø157.237;
1Ø157.238; 1.D.157.239; 1Ø157.154; 1Ø157.157; 1.D.157.166; 1Ø157.169;
1Ø157.172; 1.D.157.175; 1Ø157.240; 1Ø157.244; 1.D.166.228; 1.D.166.229;
1Ø166.230; 1Ø166.231;1.D.166.236; 1Ø166.237; 1Ø166.238; 1Ø166.239;
1.D.166.154; 1Ø166.157; 1.D.166.166; 1Ø166.169; 1.D.166.172; 1.D.166.175;
1Ø166.240; 1.D.166.244; 1.D.169.228; 1Ø169.229; 1.D.169.230;1Ø169.231;
1Ø169.236; 1.D.169.237;1Ø169.238; 1Ø169.239; 1.D.169.154;1Ø169.157;
1Ø169.166; 1Ø169.169; 1.D.169.172; 1.D.169.175; 1.D.169.240;1Ø169.244;
1Ø172.228; 1.D.172.229; 1Ø172.230; 1Ø172.231; 1Ø172.236; 1Ø172.237;

1.D.172.238;1.D.172.239; 1.D.172.154; 1.D.172.157; 1.D.172.166;1.D.172.169;
1.-D:172.172; 1.D.172.175; 1.D.172.240; 1.D.172.244; 1.D.175.228; 1.D.175.229;
1.D.175.230; 1.D.175.231; 1.D.175.236;1.D.175.237; 1.12175.238; 1.D.175.239;
1.D.175.154;1.D.175.157; 1.D.175.166;1.D.175.169; 1.D.175.172; 1.D.175.175;
1.D.175.240;1.D.175.244; 1.D.240.228; 1.D.240.229; 1.D.240.230; 1.D.240.231;
1.D.240.236; 1.D.240.237; 1.D.240.238; 1.12240.239; 1.D.240.154; 1.D.240.157;
1.D.240.166;1.D.240.169; 1.D.240.172;1.D.240.175; 1.D.240.240; 1.D.240.244;
1.D.244.228; 1.D.244.229; 1.D.244.230; l.D.244.231; 1.12244.236; 1.D.244.237;
1.D.244.238;1.D.244.239; 1.D.244.154; 1.12244.157; 1.D.244.166; 1.D.244.169;
1.D.244.172; 1.D.244.175; 1.D.244.240; 1.D.244.244;

Prodrugs of 1.E
1.E.228.228; 1.E.228.229; 1.E.228.230; 1.E.228.231; 1.E_228.236; 1.E.228.237;
1:E.228.238; 1.E.228.239; 1.E.228.154; 1.E.228.157; 1.E.228.166; 1.E.228.169;
1.E.228.172; 1.E.228.175; 1.E.228.240; 1.E.228.244; 1.E.229.228; 1.E.229.229;
1.E229.230; 1.E.229.231; 1.E.229.236; 1.E.229.237; 1.E.229.238; 1.E.229.239;
1.E.229.154; 1.E.229.157; 1.E.229.166; 1.E.229.169; 1.E.229.172; 1.E.229.175;
1.E.229.240; 1.E.229.244; 1.E.230.228; 1.E.230.229; 1.E.230.230; 1.E.230.231;
1.E.230.236; 1.E.230.237; 1.E.230.238; 1.E.230.239; 1.E.230.154;1.E.230.157;
1.E.230.166; 1.E.230.169; 1.E.230.172; 1.E.230.175; 1.E.230.240; 1.E.230.244;
1.E.231.228; 1.E.231.229; 1.E.231.230; 1.E.231.231; 1.E.231.236; 1.E.231.237;
1.E.231.238; 1.E.231.239; 1.E.231.154; 1.E.231.157; 1.E.231.166; 1.E.231.169;
1.E.231.172; 1.E.231.175; 1.E.231.240; 1.E.231.244; 1.E.236.228; LE.236.229;
1.E.236.230; 1.E.236.231; 1.E.236.236; 1.E.236.237; 1.E.236.238; 1.E.236.239;
1.E.236.154; 1.E.236.157;.1.E.236.166; 1.E.236.169; 1.E.236.172; LE.236.175;
1.E.236.240; 1.E.236.244; 1.E.237.228; 1.E.237.229; 1.E.237.230; 1.E.237.231;
1.E237.236; 1.E.237.237; 1.E.237.238; 1.E.237.239; 1.E.237.154; 1.E.237.157;
1.E.237.166; 1.E.237.169; 1.E.237.172; i.E.237.175; 1.E.237.240; LE.237.244;
1.E.238.228; 1.E.238.229; 1.E.238.230; 1.E.238.231; 1.E.238.236; 1.E.238.237;
1.E.238.238; 1.E.238.239; 1.E.238.154; 1.E.238.157; 1.E.238.166; LE.238.169;
1.E.238.172; 1.E.238.175; 1.E.238.240; I.E.238.244; 1.E.239.228; 1.E.239.229;

1.E.239.230; 1.E.239.231; 1.E.239.236;1.E.239.237; 1.E.239.238; 1.E.239.239;
1.E.239.154; 1.E.239.157; 1.E.239.166; 1.E.239.169; 1.E.239.172; 1.E.239.175;
1.E.239.240; 1.E.239.244;1.E.154.228; 1.E.154.229; 1.E.154.230; 1.E.154.231;
1.E.154.236; 1.E.154:237; 1.E.154.238; 1:E.154.239; 1.E.154.154; 1.E.154.157;
1.E.154.166; 1.E.154.169; 1.E.154.172; 1.E.154.175; 1.E.154.240; 1.E.154.244;
1.E.157.228; 1.E.157.229; 1.E.157.230; 1.E.157.231; 1.E.157.236; 1.E.157.237;
1.E.157.238; 1.E.157.239; 1.E.157.154; 1.E.157.157; 1.E.157.166; 1.E.157.169;
1.E.157.172; 1.E.157.175; 1.E.157.240; 1.E.157.244; 1.E.166.228; 1.E.166.229;
1.E.166.230; 1.E.166.231; 1.E.166.236; 1.E.166.237; 1.E.166.238; 1.E.166.239;
1.E.166.154; 1.E.166.157;1.E.166.166; 1.E.166.169; 1.E.166.172; 1.E.166.175;
1.E.166.240; 1.E.166.244; 1.E.169.228; 1.E.169.229; 1.E.169.230; 1.E.169.231;
1.E.169.236; 1.E.169.237; 1.E.169.238; 1.E.169.239; 1.E.169.154; 1.E.169.157;
1.E.169.166; 1.E.169.169; 1.E.169.172; 1.E.169.175; 1.E.169.240; 1.E.169.244;
1.E.172.228; 1.E.172.229; 1.E.172.230; 1.E.172.231; 1.E.172.236; 1.E.172.237;
1.E.172.238; 1.E.172.239; 1.E.172.154; 1.E.172.157; 1.E.172.166; 1.E.172.169;
1.E.172.172; 1.E.172.175; 1.E.172.240; 1.E.172.244; 1.E.175.228; 1.E.175.229;
1.E.175.230; 1.E.175.231; 1.E.175.236; 1.E.175.237; 1.E.175.238; 1.E.175.239;
1.E.175.154; 1.E.175.157; 1.E.175.166; 1.E.175.169; 1.E.175.172; 1.E.175.175;
1.E.175.240; 1.E.175.244; 1.E.240.228; 1.E.240.229; 1.E.240.230; 1.E.240.231;
1.E.240.236; 1.E.240.237; 1.E.240.238; 1.E.240.239; 1.E.240.154; 1.E.240.157;
1.E.240.166; 1.E.240.169; 1.E.240.172; 1.E.240.175; 1.E.240.240; 1.E.240.244;
1.E.244.228; 1.E_244.229; 1.E.244.230; 1.E.244.231; 1.E.244.236; 1.E.244.237;
.1.E.244.238; 1.E.244.239; 1.E.244.154; 1.E.244.157; 1.E.244.166; 1.E.244.169;
1.E.244.172; 1.E.244.175; 1.E.244.240; 1.E.244.244;

Prodrugs o f 1.G
1.G.228.228; 1.G.228.229; 1.G.228.230; 1.G.228.231; 1.G.228.236; 1.G.228.237;
1.G.228.238; 1.G.228.239; 1.G.228.154; 1.G.228.157; 1.G.228.166; 1.G.228.169;
1.G.228.172; 1.G.228.175; 1.G.228.240; 1.G.228.244; 1.G.229.228; 1.G.229.229;
1.G.229.230; 1.G.229.231; 1.G.229.236; 1.G.229.237; 1.G.229.238; 1.G.229.239;
1.G.229.154; 1.G.229.157; 1.G.229.166; 1.G.229.169; 1.G.229.172; 1.G.229.175;

1.G.229.240; 1.G.229.244; 1.G.230.228; 1.G230.229; 1.G.230.230; 1.G.230.231;
1.G.230.236;1.G.230.237;1.G.230.238;1.G.230.239;1.G.230.154; 1.G.230.157;
1.G.230.166; 1.G.230.169; 1.G.230.172; 1, G.230.175; 1.G.230.240; 1.G.230.244;
1.G.231.228;1.G.231.229;1.G.231.230; 1.G.231.231;1.G.231.236;1.G.231.237;
1.G.231.238;1.G.231.239; 1.G.231.154; 1.G.231.157; 1.G.231.166; 1.G.231.169;
1.G.231.172; i.G.231.175; 1.G.231.240; 1.G.231.244; 1.G.236.228; 1.G.236.229;
1.G.236.230; 1.G.236.231; 1.G.236.236; 1.G.236.237; 1.G_236.238; 1.G.236.239;
1.G.236.154;1.G.236.157; 1.G.236.166; 1.G.236.169; 1.G.236.172; 1.G.236.175;
1.G.236.240;1.G.236.244; 1.G.237.228;1.G.237.229;1.G.237.230;1.G.237.231;
1.G.237.236; 1.G.237.237; 1.G.237.238; 1.G.237.239; 1.G.237.154; 1.G.237.157;
1.G.237.166; 1.G.237.169;1.G.237.172; 1.G.237.175; 1.G.237.240; 1.G.237.244;
1.G.238.228; 1.G.238.229; 1.G.238.230; 1.G.238.231; 1.G.238.236; 1.G.238.237;
1.G.238.238;1.G.238.239;1.G.238.154; 1.G.238.157;1.G.238.166; 1.G.238.169;
1.G.238.172; 1.G.238.175; 1.G.238.240; 1.G.238.244; 1.G.239.228; 1.G.239.229;
1.G.239.230;1.G.239.231; 1.G.239.236;1.G.239.237;1.G.239.238; 1.G.239.239;
1.G.239.154;1.G.239.157; 1.G.239.166;1.G.239.169;1.G.239.172; 1.G.239.175;
1.G.239.240; 1.G.239.244; 1.G.154.228; 1.G.154.229; 1.G.154.230; 1.G.154.231;
1.G.154.236; 1.G.154.237; 1.G.154.238; 1.G.154.239; 1.G.154.154; 1.G.154.157;
1.G.154.166; 1.G.154.169; 1.G.154.172; 1.G.154.175; 1.G.154.240; 1.G.154.244;
1.G.157.228;1.G.157.229; 1.G.157.230; 1.G.157.231; 1.G.157.236; 1.G.157.237;
1.G.157.238; 1.G.157.239; 1.G.157.154; 1.G.157.157; 1.G.157.166; 1.G.157.169;
1.G.157.172; 1.G.157.175; 1.G.- 157.240; 1.G.157.244; 1.G.166.228;
1.G.166.229;
1.G.166.230;1.G.166.231;1.G.166.236; 1.G.166.237; 1.G.166.238; 1.G.166.239;
1.G.166.154; 1.G.166.157; 1.G.166.166; 1.G.166.169; 1.G.166.172; 1.G.166.175;
1.G.166.240; 1.G.166.244; 1.G.169.228; 1.G.169.229; 1.G.1.69.230; I.G.169.231;
1.G.169.236;1.G.169.237; 1.G.169.238; 1.G.169.239; 1.G.169.154; 1.G.169.157;
1.G.169.166; 1.G.169.169; 1.G.169.172; 1.G.169.175; 1.G.169.240; 1.G.169.244;
1.G.172.228;1.G.172.229; 1.G.172.230; 1.G.172.231; 1.G.172.236; 1.G.172.237;
1.G.172.238; 1.G.172.239; 1.G.172.154; 1.G.172.157; 1.G.172.166; 1.G.172.169;
1.G.172.172; 1.G.172.175; 1.G.172.240; 1.G.172.244; 1.G.175.228; 1.G.175.229;
1.G.175.230;1.G.175.231; 1.G.175.236; 1.G.175.237; 1.G.175.238; 1.G.175.239;

1.G.175.154;1.G.175.157; 1.G.175.166; 1.G.175.169; 1.G.175.172; 1.G.175.175;
1.G.175.240; 1.G.175.244; 1.G.240.228; 1.G.240.229; 1.G.240.230; 1.G.240.231;
1.G.240.236;1.G.240.237; 1.G.240.238; 1.G.240.239; 1.G.240.154; 1.G.240.157;
1.G.240.166; 1.G.240.169; 1.G.240.172; 1.G.240.175; 1.G.240.240; 1.G.240.244;
1.G.244.228;1.G.244.229; 1.G.244.230; 1.G.244.231; 1.G.244.236; 1.G.244.237;
1.G.244.238;1.G.244.239; 1.G.244.154; 1.G.244.157; 1.G.244.166; 1.G.244.169;
1.G.244.172; 1.G.244.175; 1.G.244.240; 1.G.244.244;

Prodru s~ of 1.1 1.1.228.228; 1.1.228.229; 1.1.228.230; 1.1.228.231; 1.1.228.236; 1.1.228.237;
1.1.228.238; 1.1.228.239; 1.1.228.154; 1.1.228.157; 1.1.228.166; 1.1.228.169;
11.228.172;
1.1.228.175; 1.1.228.240; 1.1.228.244; 1.1.229.228;1.1.229.229;
1.1.229.230;1.1.229.231;
1.1.229.236; 1.1.229.237; 1.1.229.238; 1.1.229.239;1.1.229.154;
1.1.229.157;1.1.229.166;
1.1.229.169;1.1.229.172; 1.1.229.175; 1.1.229.240;1.1.229.244;
1.1.230.228;1.1.230.229;
1.1.230.230; 1.1.230.231; 1.1.230.236; 1.1.230.237; 1.1.230.238; 1.1.230.239;
1.1.230.154;
1.I.230.157; 1.I.230.166; 1.1.230.169; 11.230.172;1.1.230.175; 1.1.230.240;
1.1.230.244;
1.1.231.228; 1.1.231.229; 1.1.231.230; 1.1.231.231;1.1.231.236; 1.1.231.237;
1.1.231.238;
1.1.231.239; 1.1.231.154; 1.I.231.157; 1.I.231.166; 1.1.231.169; 1.1.231.172;
1.1.231.175;
1.1.231.240; 1.1.231.244; 1.1.236.228; 1.1.236.229; 1.1.236.230; 1.1.236.231;
1.1.236.236;
1.1.236.237; 1.1.236.238; 1.1.236.239; 1.1.236.154; 1.1.236.157; 1.1.236.166;
1.1.236.169;
1.1.236.172;1.1.236.175; 1.1.236.240; 1.1.236.244;1.1.237.228;
1.1.237.229;1.1.237.230;
1.1.237.231;1.1.237.236; 14.237.237; 1.1.237.238; 1.1.237.239;
1.1.237.154;1.1.237.157;
1.1.237.166; 1.1.237.169; 1.1.237.172; 1.1.237.175;1.1.237.240; 1.1.237.244;
1_1.238.228;
1.1.238.229; 1.1.238.230; 1.1.238.231; 1.I.238:236; 1.1.238.237; 1.1.238.238;
1.1.238.239;
1.1.238.154; 1.1.238.157; 1.1.238.166; 1.1.238.169; 1.1.238.172; 1.1.238.175;
1.1.238.240;
1.1.238.244;1.1.239.228;11.239.229; 1.1.239.230;1.1.239.231;
1.1.239.236;1.1.239.237;
1.1.239.238; 1.1.239.239; 1.1.239.154; 1.1.239.157;1.1.239.166;
1.1.239.169;11.239.172;
1.1.239.175; 1.1.239.240; 1.1.239.244; 1.1.154.228; 1.1.154.229; 1.1.154.230;
1.1.154.231;
1.1.154.236; 1.1.154.237; 1.1.154.238; 1.1.154.239; 1.1.154.154; 1.1.154.157;
1.1.154.166;
1.1.154.169; 1.1.154.172; 1.1.154.175; 1.1.154.240;1.1.154.244;
1.1.157.228;1.1.157.229;
11157.230; 1.1.157.231; 1.1.157.236; 1.1.157.237; 1.1.157.238;
1.1.157.239;1.1.157.154;

1.1.157.157; 1.1.157.166; 1.1.157.169; 1.1.157.172; 1.1.157.175; 1.1.157.240;
1.1.157.244;
1.1.166.228; 11166.229;1.1.166.230; 1.1.166.231; 1.1.166.236; 1.1.166.237;
1.1.166.238;
1.1.166.239; 1.1.166.154; 1.1.166.157; 1.1.166.166; 1.1.166.169; 1.1.166.172;
1.1.166.175;
1.1.166.240; 1.1.166.244;1.1.169.228;
1.1.169.229;1.1.169.230;1.1.169.231;1.1.169.236;
1.1.169.237;
1.1.169.238;1.1.169.239;1.1.169.154;1.1.169.157;1.1.169.166;1.1.169.169;
1.1.169.172; 1.1.169.175; 1.1.169.240; 1.1.169.244; 1.1.172.228; 1.1.172.229;
1.1.172.230;
1.1.172.231; 1.1.172.236; 1.1.172.237; 1.1.172.238; 1.1.172.239; 1.1.172.154;
1.1.172.157;
1.1.172.166; 1.1.172.169; 1.1.172.172; 1.1.172.175; 1.1.172.240; 1.1.172.244;
1.1.175.228;
1.1.175.229; 1.1.175.230;1.1.175.231;
1.1.175.236;1.1.175.237;1.1.175.238;1.1.175.239;
1.1.175.154; 1.1.175.157; 1.1.175.166; 1.1.175.169; 1.1.175.172;'1.1.175.175;
1.1.175.240;
1.1.175.244; 1.1.240.228; 1.1.240.229; 1.1.240.230; 1.1.240.231; 1.1.240.236;
1.1.240.237;
1.1.240.238; 1.1.240.239;1.1.240.154;
1.1.240.157;1.1.240.166;1.1.240.169;1.1.240.172;
1.1.240.175; 1.1.240.240; 1.1.240.244; 1.1.244.228; 1.1.244.229; 1.1.244.230;
1.1.244.231;
1.1.244.236; 1.1.244.237; 1.1.244.238; 1.1.244.239; 1.1.244.154; 1.1.244.157;
1.1.244.166;
1.1.244.169; 1.1.244.172;1.1.244.175; 1.1.244.240; 1.1.244.244;
Prodrugs of 1.1 1.J.228.228; 1.J.228.229; 1.J.228.230; 1.J.228.231; 1.J.228.236; 1.j.228.237;
1.J.228.238; 1.J.228.239; 1.J.228.154; 1.J.228.157; 1.1.228.166; 1.J.228.169;
1.j.228.172;
1.J.228.175; 1.J.228.240; 1.J.228.244; 1.J.229.228; 1.J.229.229; 1.J.229.230;
1.J.229.231;
1.j.229.236; 1.J.229.237; 1.J.229.238; 1.J.229.239; 1.J.229.154; 1.J.229.157;
1.J.229.166;
1.J.229.169; 1.J.229.172; 1.J.229.175; 1.j.229.240; 1.J.229.244; 1.J.230.228;
1.J.230.229;
1.J.230.230; 1.J.230.231; 1.J.230.236;1.J.230.237; 1.J.230.238; 1.J.230.239;
1.j.230.154;
1.J.230.157; 1.J.230.166; 1.J.230.169; 1.j.230.172; 1.J.230.175; 1.J.230.240;
1.J.230.244;
1.J.231.228; 1.J.231.229; 1.J.231.230; 1.J.231.231; 1.J.231.236; 1.J.231.237;
1.J.231.238;
1.J.231.239; 1.J.231.154; 1.J.231.157; 1.j.231.166; 1.J.231.169; 1.j.231.172;
1.j.231.175;
1.J.231.240; 1.J.231.244; 1.J.236.228; 1.J.236.229; 1.J.236.230;1.J.236.231;
1.J.236.236;
1.J.236.237; 1.J.236.238; 1.J.236.239;1.j.236.154; 1.J.236.157;1.J.236.166;
1.J.236.169;
1.J.236.172; 1.j.236.175; 1.J.236.240; 1.J.236.244; 1.J.237.228; 1.J.237.229;
1.J.237.230;
1.J.237.231; 1.J.237.236; 1.j.237.237; 1.J.237.238; 1.J.237.239; 1.J.237.154;
1.J.237.157;
1.J.237.166; 1.J.237.169; 1.J.237.172; 1.j.237.175; 1.1.237.240; 1.J.237.244;
1.J.238.228;

1.J.238.229; 1.J.238.230; 1.J.238.231; 1.J.238.236;1.J.238.237;
1.J.238.238;1.J.238.239;
1.J.238.154; 1.J.238.157; 1.J.238.166; 1.J.238.169; 1.J.238.172; 1.J.238.175;
1.J.238.240;
1.J.238.244; 1.J.239.228; 1.J.239.229; 1.J.239.230; 1.J.239.231; 1.J.239.236;
1.J.239.237;
1.J.239.238; 1.J.239.239; 1.J.239.154; 1.J.239.157;1.J.239.166; 1.j.239.169;
1.J.239.172;
1.J.239.175; 1.J.239.240; 1.J.239.244; 1.J.154.228; 1.J.154.229;
1.J.154.230;1.J.154.231;
1.J.154.236; 1.J.154.237; 1.J.154.238; 1.J.154.239; 1.J.154.154; 1.J.154.157;
1.J.154:166;
1.J.154.169; 1.J.154.172; 1.J.154.175; 1.J.154.240; 1.J.154.244; 1.J.157.228;
1.J.157.229;
1.J.157.230; 1.J.157.231; 1.J.157.236; 1.J.157.237; 1.J.157.238; 1.j.157.239;
1.J.157.154;
1.J.157.157;1.J.157.166; 1.J.157.169; 1.J.157.172; 1.J.157.175; 1.J.157.240;
1.j.157.244;
1.J.166.228; 1.J.166.229; 1.J.166.230; 1.J.166.231; 1.J.166.236; 1.J.166.237;
1.J.166.238;
1.J.166.239; 1.J.166.154; 1.J.166.157; 1.J.166.166; 1.J.166.169; 1.J.166.172;
1.J.166.175;
1.J.166.240; 1.J.166.244; 1.J.169.228; 1.J.169.229; 1.J.169.230; 1.J.169.231;
1.J.169.236;
1.J.169.237; 1.J.169.238; 1.J.169.239; l.J.169.154; 1.J.169.157; 1.J.169.166;
1.J.169.169;
1.J.169.172; 1.J.169.175; 1.J.169.240; 1.J.169.244; 1.J.172.228; 1.J.172.229;
1.J.172.230;
1.J.172.231; 1.J.172.236; 1.J.172.237; 1.J.172.238; 1.J.172.239; 1.J.172.154;
1.J.172.157;
1.J.172.166; 1.J.172.169; 1.J.172.172; 1.J.172.175; 1.J.172.240; 1.J.172.244;
1.J.175.228;
1.j.175.229; 1.J.175.230; 1.J.175.231; 1.J.175.236; 1.J.175.237; 1.J.175.238;
1.J.175.239;
1.J.175.154; 1.J.175.157; 1.J.175.166; 1.J.175.169; 1.1.175.172; 1.J.175.175;
1.J.175.240;
1.J.175.244; 1.J.240.228; 1.J.240.229; 1.J.240.230; 1.J.240.231; 1.J:240.236;
1.J.240.237;
1.J.240.238; 1.J.240.239; 1.J.240.154; 1.J.240.157; 1:J.240.166; 1.J.240.169;
1.J.240.172;
1.J.240.175; 1.J.240.240; 1.J.240.244; 1.J.244.228; 1.J.244.229; 1.j.244.230;
1.J.244.231;
1.J.244.236; 1.J.244.237; 1.J.244.238; 1.J.244.239; 1.J.244.154; 1.J.244.157;
1.J244.166;
1.J.244.169; 1.J.244.172; 1.J.244.175; 1.J.244.240; 1.J.244.244;

Prodrugs of 1.L .
1.L.228.228; 1.L.228.229; 1.L.228.230; 1.L.228.231; 1.L.228.236; 1.L.228.237;
1.L.228.238; 1.L.228.239; 1.L.228.154; 1.L.228.157;1.L.228.166;1.L.228.169;
1.L.228.172; 1.L.228.175; 1.L.228.240; 1.L.228.244; 1.L.229.228; 1.L.229.229;
1.L.229.230; 1.L.229.231; 1.L.229.236; 1.L.229.237; 1.L.229.238; 1.L.229.239;
1.L.229.154; 11.229.157; 1.L.229.166; 1.L.229.169; 1.L.229.172; 1.L.229.175;
1.L.229.240; 1.L.229.244; 1.L.230.228; 1.L.230.229;1.L.230:230;1.L.230.231;

1.L.230.236; 11.230.237; 1.L.230.238; 1.L.230.239; 1.L.230.154; 1.L.230.157;
1.L.230.166; 1.L.230.169; 1.L.230.172; 1.L.230.175; 1.L.230.240; 1.L.230.244;
1.L.231.228; 1.L.231.229;1.L.231.230;1.L.231.231;1.L.231.236;1.L.231.237;
1.L.231.238; 1.L.231.239; 1.L.231.154; 1.L.231.157; 1.L.231.166; 1.L.231.169;
11.231.172; 1.L.231.175; 1.L.231.240; 1.L.231.244; 1.L.236.228; 1.L.236.229;
1.L.236.230; 1.L.236.231;1.L.236.236;1.L.236.237; 1.L.236.238; 1.L.236.239;
1.L.236.154; 1.L.236.157; 1.L.236.166; 1.L.236.169; 1.L.236.172; 1.L.236.175;
1_L.236.240;1.L.236.244; 11.237.228;1.L.237.229; 1.L.237.230; 1.L.237.231;
11.237.236;1.L.237.237;1.L.237.238;1.L.237.239; 1.L.237.154;1.L.237.157;
1.L.237.166;1.L.237.169; 1.L.237.172; 1.L.237.175; 1.L.237.240; 1.L.237.244;
1.L.238.228;1.L.238.229;1.L.238.230; 1.L.238.231; 1.L.238.236; 1.L.238.237;
1.L.238.238; 1.L.238.239; 1.L.238.154; 1.L.238.157; 1.L.238.166; 11.238.169;
11.238.172; 1.L.238.175; 1.L.238.240; 1.L.238.244; 1.L.239.228; 1.L.239.229;
1.L.239.230; 1.L.239.231;1.L.239.236;1.L.239.237; 1.L.239.238; 1.L.239.239;
1.L.239.154; 1.L.239.157;1.L.239.166;11.239.169; 1.L.239.172; 1.L.239.175;
1.L.239.240; 1.L.239.244; 1.L.154.228; 1.L.154.229; 1.L.154.230; 1.L.154.231;
1.L.154.236; 1.L.154.237;1.L.154.238;1.L.154.239; 1.L.154.154; 1.L.154.157;
1.L.154.166; 1.L.154.169; 1.L.154.172; 1.L.154.175; 1.L.154.240; 1.L.154.244;
1.L.157.228; 1.L.157.229;1.L.157.230; 1.L.157.231; 1.L.157.236; 1.L.157.237;
1.L.157.238; 1.L.157.239; 1.L.157.154; 1.L.157.157; 1.L.157.166; 1.L.157.169;
1.L.157.172; 1.L.157.175; 1.L.157.240; 1.L.157.244; 1.L.166.228; 1.L.166.229;
1.L.166.230; 11.166.231;1.L.166.236; 1.L.166.237; 1.L.166.238; 1.L.166.239;
1.L.166.154; 1.L.166.157;1.L.166.166;1.L.166.169; 1.L.166.172; 1.L.166.175;
1.L.166.240; 1.L.166.244; 11.169.228; 1.L.169.229; 1.L.169.230; 1.L.169.231;
1.L.169.236; 1.L.169.237; 1.L.169.238; 1.L.169.239; 1.L.169.154; 1.L.169.157;
1.L.169.166; 1.L.169.169; 1.L.169.172;1.L.169.175;1.L.169.240; 1.L.169.244;
1.L.172.228; 1.L.172.229; 1.L.172.230; 1.L.172.231;1.L.172.236; 1.L.172.237;
1.L.172.238; 1.L.172.239; 1.L.172.154;1.L.172.157;1.L.172.166; 1.L.172.169;
1.L.172.172; 1.L.172.175; 1.L.172.240; 1.L.172.244;1.L.175.228; 1.L.175.229;
1.L.175.230; 1.L.175.231; 1.L.175.236; 1.L.175.237; 1.L.175.238; 1.L.175.239;

1.L.175.154; 1.L.175.157; 1.L.175.166; 1.L.175.169; 11.175.172; 11.175.175;

1.L.175.240; 1.L.175.244; 1.L.240.228; 1.L.240.229; 1.L.240.230; 1.L.240.231;
1.L.240.236; 1.L.240.237; 1.L.240.238; 1.L.240.239; 1.L.240.154; 1.L.240.157;
1.L.240.166; 1.L.240.169; 1.L.240.172; 1.L.240.175; 11.240.240; 1.L.240.244;
1.L.244.228; 1.L.244.229; 1.L.244.230; 1.L.244.231; 1.L.244.236; 1.L.244.237;
1.L.244.238; 1.L.244.239; 1.L.244.154; 1.L.244.157; 1.L.244.166; 1.L.244.169;
1.L.244.172; 1.L.244.175; 1.L.244.240; 1.L.244.244;
Prodrugs of 1.0 1Ø228.228; 1Ø228.229; 1Ø228.230; 1Ø228.231; 1Ø228.236; 1Ø228.237;
1Ø228.238;1Ø228.239;1Ø228.154;1Ø228.157;1Ø228.166; 1Ø228.169;
1Ø228.172; 1Ø228.175; 1Ø228.240; 1Ø228.244; 1Ø229.228; 1Ø229.229;
1Ø229.230; 1Ø229.231; 1Ø229.236; 1Ø229.237; 1Ø229.238; 1Ø229.239;
1Ø229.154; 1Ø229.157; 1Ø229.166; 1Ø229.1'69; 1Ø229.172; 1Ø229.175;
1Ø229.240; 1Ø229.244; 1Ø230.228; 1Ø230.229; 1Ø230.230; 1Ø230.231;
1Ø230.236; 1Ø230.237; 1Ø230.238; 1Ø230.239; 1Ø230.154; 1Ø230.157;
1Ø230.166; 1Ø230.169; 1Ø230.172; 1Ø230.175; 1Ø230.240; 1Ø230.244;
1Ø231.228; 1Ø231.229; 1Ø231.230; 1Ø231.231; 1Ø231.236; 1Ø231.237;
1Ø231.238; 1Ø231.239; 1Ø231.154; 1Ø231.157; 1,0.231.166; 1Ø231.169;
1Ø231.172; 1Ø231.175; 1Ø231.240; 1Ø231.244; 1Ø236.228; 1Ø236.229;
1Ø236.230; 1Ø236.231; 1Ø236.236; 1Ø236.237; 1Ø236.238; 1Ø236.239;
1Ø236.154; 1Ø236.157; 1Ø236.166; 1Ø236.169; 1Ø236.172; 1Ø236.175;
1Ø236.240; 1Ø236.244; 1Ø237.228; 1Ø237.229; 1Ø237.230; 1Ø237.231;
1Ø237.236; 1Ø237.237; 1Ø237.238; 1Ø237.239; 1Ø237.154; 1Ø237.157;
1Ø237.166; 1Ø237.169; 1Ø237.172; 1Ø237.175; 1Ø237.240; 1Ø237.244;
1Ø238.228; 1Ø238.229; 1Ø238.230; 1Ø238.231; 1Ø238.236; 1Ø238.237;
1Ø238.238; 1Ø238.239; 1Ø238.154; 1Ø238.157; 1Ø238.166; 1Ø238.169;
1Ø238.172; 1Ø238.175; 1Ø238.240; 1Ø238.244; 1Ø239.228; 1Ø239.229;
1Ø239.230; 1Ø239.231; 1Ø239.236; 1Ø239.237; 1Ø239.238; 1Ø239.239;
1Ø239.154; 1Ø239.157; 1Ø239.166; 1Ø239.169; 1Ø239.172; 1Ø239.175;
1Ø239.240; 1Ø239.244; 1Ø154.228; 1Ø154.229; 1Ø154.230; 1Ø154.231;
1Ø154.236; 1Ø154.237; 1Ø154.238; 1Ø154.239; 1Ø154.154; 1Ø154.157;

1Ø154.166; 1Ø154.169; 1Ø154.172; 1Ø154.175; 1Ø154.240; 1Ø154.244;
1Ø157.228; 1Ø157.229; 1Ø157.230; 1Ø157.231; 1Ø157.236;1Ø157.237;
1Ø157.238; 1Ø157.239; 1Ø157.154; 1Ø157.157; 1Ø157.166; 1Ø157.169;
1Ø157.172; 1Ø157.175; 1Ø157.240; 1Ø157.244; 1Ø166.228; 1Ø166.229;
1Ø166.230; 1Ø166.231; 1Ø166.236; 1Ø166.237; 1Ø166.238; 1Ø166.239;
1Ø166.154; 1Ø166.157; 1Ø166.166; 1Ø166.169; 1Ø166.172; 1Ø166.175;
1Ø166.240;1Ø166.244;1Ø169.228;1Ø169.229; 1Ø169.230; 1Ø169.231;
1Ø169.236; 1Ø169.237; 1Ø169.238; 1Ø169.239; 1Ø169.154; 1Ø169.157;
-1Ø169.166; 1Ø169.169; 1Ø169.172; 1Ø169.175; 1Ø169.240; 1Ø169.244;
1Ø172.228; 1Ø172.229; 1Ø172.230; 1Ø172.231; 1Ø172.236; 1Ø172.237;
1Ø172.238; 1Ø172.239; 1Ø172.154; 1Ø172.157; 1Ø172.166; 1Ø172.169;
1Ø172.172; 1Ø172.175; 1Ø172.240; 1Ø172.244; 1Ø175.228; 1Ø175.229;
1Ø175.230; 1Ø175.231; 1Ø175.236; 1Ø175.237; 1Ø175.238; 1Ø175.239;
1Ø175.154; 1Ø175.157; 1Ø175.166; 1Ø175.169; 1.0175.172; 1Ø175.175;
1Ø175.240; 1Ø175.244; 1Ø240.228; 1Ø240.229; 1Ø240.230; 1Ø240.231;
1Ø240.236; 1Ø240.237; 1Ø240.238; 1Ø240.239; 1Ø240.154; 1Ø240.157;
1Ø240.166; 1Ø240.169; 1Ø240.172; 1Ø240.175; 1Ø240.240; 1Ø240.244;
1Ø244.228; 1Ø244.229; 1Ø244.230; 1Ø244.231; 1Ø244.236; 1Ø244.237;
1Ø244.238; 1Ø244.239; 1Ø244.154; 1Ø244.157; 1Ø244.166; 1Ø244.169;
1Ø244.172; 1Ø244.175; 1Ø244.240; 1Ø244.244;
Prodrugs of 1.P
' 1.P.228.228; 1.P.228.229; 1.P.228.230; 1.P.228.231; 1.P.228.236;
1.P.228.237;
1.P.228.238; 1.P.228.239; 1.P.228.154; 1.P.228.157; 1.P.228.166; 1.P.228.169;
1.P.228._172; 1.P.228.175; 1.P.228.240; 1.P.228.244; 1.P.229.228; 1.P.229.229;
1.P.229.230; 1.P.229.231; 1.P.229.236; 1.P.229.237; 1.P.229.238; 1.P.229.239;
1.P.229.154; 1.P.229.157; 1.P.229.166; 1.P.229.169; 1.P.229.172; 1.P.229.175;
1.P.229.240; 1.P.229.244; 1.P.230.228; 1.P.230.229; 1.P.230.230; 1.P.230.231;
1.P.230.236; 1.P.230.237; 1.P.230.238; 1.P.230.239; 1.P.230.154; 1.P.230.157;
1.P.230.166; 1.P.230.169; 1.P.230.172; 1.P.230.175; 1.P.230.240; 1.P.230.244;
1.P.231.228; 1.P.231.229; 1.P.231.230; 1.P.231.231; 1.P.231.236; 1.P.231.237;

1.P.231.238; 1.P.231.239; 1.P.231.154; 1.P.231.157; 1.P.231.166; 1.P.231.169;
1.P.231.172; 1.P.231.175; 1.P.231.240; 1.P.231.244; 1.P.236.228; 1.P.236.229;
1.P.236.230; 1.P.236.231; 1.P.236.236; 1.P.236.237; 1.P.236.238; 1.P.236.239;
1.P.236.154;1.P.236.157; 1.P.236.166;1.P.236.169;1.P.236.172;1.P.236.175;
1.P.236.240; 1.P.236.244; 1.P.237.228; 1.P.237.229; 1.P.237.230;1.P.237.231;
1.P.237.236; 1.P.237.237; 1.P.237.238; 1.P.237.239; 1.P.237.154; 1.P.237.157;
1.P.237.166; 1.P.237.169; 1.P.237.172; 1.P.237.175;1.P.237.240; 1.P.237.244;
1.P.238.228; 1.P.238.229; 1.P.238.230; 1.P.238.231; 1.P.238.236; 1.P.238.237;
1.P.238.238; 1.P.238.239; 1.P.238.154; 1.P.238.157;1.P.238.166; 1.P.238.169;
1.P.238.172; 1.P.238.175; 1.P.238.240; 1.P.238.244; 1.P.239.228; 1.P.239.229;
1.P.239.230; 1.P.239_231; 1.P.239.236; 1.P.239.237; 1.P:239.238; 1.P.239.239;
1.P.239.154; 1.P.239.157; 1.P.239.166;1.P.239.169;1.P.239.172; 1.P.239.175;
1.P.239.240; 1.P.239.244; 1.P.154.228; 1.P.154.229; 1.P.154.230; 1.P.154.231;
1.P.154.236; 1.P.154.237; 1.P.154.238; 1.P.154.239;1.P.154.154; 1.P.154.157;
1.P.154.166; 1.P.154.169; 1.P.154.172; 1.P.154.175; 1.P.154.240; 1.P.154.244;
1.P.157.228; 1.P.157.229; 1.P.157.230; 1.P.157.231; 1.P.157.236; 1.P.157.237;
1.P.157.238;1.P.157.239; 1.P.157.154; 1.P.157.157;1.P.157.166;1.P.157.169;
1.P.157.172; 1.P.157.175; 1.P.157.240; 1.P.157.244; 1.P.166.228; 1.P.166.229;
1.P.166.230; 1.P.166.231; 1.P.166.236; 1.P.166.237; 1.P.166.238; 1.P.166.239;
1.P.166.154; 1.P.166.157; 1.P.166.166; 1.P.166.169; 1.P.166.172; 1.P.166.175;
1.P.166.240; 1.P.166.244; 1.P.169.228; 1.P.169.229; 1.P.169.230; 1.P.169.231;
1.P.169.236; 1.P.169.237; 1.P.169.238; 1.P.169.239; 1.P.169.154; 1.P.169.157;
1.P.169.166; 1.P.169.169; 1.P.169.172; 1.P.169.175; 1.P.169.240; 1.P.169.244;
1.P.172.228; 1.P.172.229; 1.P.172.230; 1.P.172.231; 1.P.172.236; 1.P.172.237;
1.P.172.238; 1.P.172.239; 1.P.172.154; 1.P.172.157; 1.P.172.166; 1.P.172.169;
1.P.172.172; 1.P.172.175; 1.P.172.240; 1.P.172.244; 1.P.175.228; 1.P.175.229;
1.P.175.230; 1:P.175.231; 1.P.175.236; 1.P.175.237;1.P.175.238; 1.P.175.239;
1.P.175.154; 1.P.175.157; 1.P.175.166; 1.P.175.169;1.P.175.172; 1.P.175.175;
1.P.175.240; 1.P.175.244; 1.P.240.228; 1.P.240.229; 1.P.240.230; 1.P.240.231;
1.P.240.236; 1.P.240.237; 1.P.240.238; 1.P.240.239; 1.P.240.154; 1.P.240.157;
1.P.240.166; 1.P.240.169; 1.P.240.172; 1.P.240.175; 1.P.240.240; 1.P.240.244;

1.P.244.228; 1.P.244.229; 1.P.244.230; 1.P.244.231; 1.P.244.236; 1.P.244.237;
1.P.244.238; 1.P.244.239; 1.P.244.154; 1.P.244.157; 1.P.244.166; 1.P.244.169;
1.P.244.172; 1.P.244.175; 1.P.244.240; 1.P.244.244;

Prodrugs of 1.U
1.U.228.228; 1.U.228.229; 1.U.228.230; 1.U.228.231; 1.U.228.236; 1.U.228.237;
1.U.228.238; 1.U.228.239; 1.U.228.154; 1.U.228.157; 1.U.228.166; 1.U.228.169;
1.U.228.172; 1.U.228.175;1.U.228.240; 1.U.228.244; 1.U.229.228; 1.U.229.229;
1.U.229.230;1.U.229.231;1.U.229.236; 1.U.229.237; 1.U.229.238;1.U.229.239;
1.U.229.154; 1.U.229.157; 1.U.229.166; 1.U.229.169; 1.U.229.172; 1.U.229.175;
1.U.229.240; 1.U.229.244; 1.U.230.228; 1.U.230.229; 1.U.230.230; 1.U.230.231;
1.U.230.236; 1.U.230.237;1.U.230.238; 1.U.230.239; 1.U.230.154; 1.U.230.157;
1.U.230.166; 1.U.230.169;1.U.230.172; 1.U.230.175; 1.U.230.240;1.U.230.244;
1.U.231.228; 1.U.231.229;1.U.231.230; 1.U.231.231; 1.U.231.236; 1.U.231.237;
1.U.231.238; 1.U231.239; 1.U.231.154; 1.U.231.157; 1.U.231.166; 1.U.231.169;
1.U.231.172; 1.U.231.175; 1.U.231240; 1.U.231.244; 1.U.236.228; 1.U.236.229;
l.U.236.230; 1.U.236.231;1.U.236.236; 1.U.236.237; 1:U.236.238; 1.U.236.239;
1.U.236.154; 1.U.236.157;1.U.236.166; 1.U.236.169; 1.U.236.172;1.U.236.175;
1.U.236.240; 1.U.236.244; 1.U.237.228; 1.U.237.229; 1.U.237.230; 1.U.237.231;
1.U.237.236; 1.U.237.237; 1.U.237.238; 1.U.237.239; 1.U.237.154; 1.U.237.157;
1.U.237.166; 1.U.237.169; 1.U.237.172; 1.U.237.175; 1.U.237.240; 1.U.237.244;
1.U.238.228; 1.U.238.229; 1.U.238.230; 1.U.238.231; 1.U.238.236; 1.U.238.237;
1.U.238.238; 1.U.238.239; 1.U.238.154; 1.U.238.157; 1.U.238.166; 1.U.238.169;
1.U.238.172; 1.U.238.175; 1.U.238.240; 1.U.238.244; 1.U.239.228; 1.U.239.229;
1.U.239.230; 1.U.239.231;1.U.239.236; 1.U.239.237; 1.U.239.238; 1.U.239.239;
1.U.239.154; 1.U.239.157; 1.U.239.166; 1.U.239.169; 1.U.239.172; 1.U.239.175;
1.U.239.240; 1.U.239.244; 1.U.154.228; 1.U.154.229; 1.U.154.230; 1.U.154.231;
1.U.154.236; 1.U.154.237;1.U.154.238; 1.U.154.239; 1.U.154.154; 1.U.154.157;
1.U.154.166; 1.U.154.169; 1.U.154.172; 1.U.154.175; 1.U.154.240; 1.U.154.244;
1.U.157.228; 1.U.157.229;1.U.157.230; 1.U.157.231; 1.U.157.236; 1.U.157.237;
1.U.157.238; 1.U.157.239; 1.U.157.154; 1.U.157.157; 1.U.157.166; 1.U.157.169;

1.U.157.172; 1.U.157.175; 1.U.157.240; 1.U.157.244; 1.U.166.228; 1.U.166.229;
1.U.166.230; 1.U.166.231; 1.U.166.236; 1.U.166.237; 1.U.166.238; 1.U.166.239;
1.U.166.154;1.U.166.157; 1.U.166.166; 1.U.166.169; 1.U.166.172;1.U.166.175;
1.U.166.240; 1.U.166.244; 1.U.169.228; 1.U.169.229; 1.U.169.230; 1.U.169.231;
1.U.169.236; 1.U.169.237;1.U.169.238; 1.U.169.239; 1.U.169.154;1.U.169.157;
1.U.169.166; 1.U.169.169; 1.U.169.172; 1.U.169.175; 1.U.169.240; 1.U.169.244;
1.U.172.228; 1.U.172.229;1.U.172.230;1.U.172.231; 1.U.172.236;1.U.172.237;
1.U.172.238; 1.U.172.239; 1.U.172.154; 1.U.172.157; 1.U.172.166; 1.U.172.169;
1.U.172.172; 1.U.172.175;1.U.172.240;1.U.172.244; 1.U.175.228;1.U.175.229;
1.U.175.230; 1.U.175.231; 1.U.175.236; 1.U.175.237; 1.U.175.238; 1.U.175.239;
1.U.175.154; 1.U.175.157; 1.U.175.166; 1.U.175.169; 1.U.175.172;1.U.175.175;
1.U.175.240; 1.U.175.244; 1.U.240.228; 1.U.240.229; 1.U.240.230; 1.U.240.231;
1.U.240.236; 1.U.240.237;1.U.240.238; 1.U.240.239; 1.U.240.154;1.U.240.157;
1.U.240.166; 1Ø240.169; 1.U.240.172; 1.U.240.175; 1.U.240.240; 1.U.240.244;
1.U.244.228; 1.U.244.229; 1.U.244.230; 1.U.244.231; 1.U.244.236; 1.U.244.237;
1.U.244.238; 1.U.244.239; 1.U.244.154; 1.U.244.157; 1.U.244.166; 1.U.244.169;
1.U.244.172; 1.U.244.175;1.U.244.240; 1.U.244.244;

Prodrugs of 1.W
1.W.228.228; 1.W.228.229; 1.W.228.230; 1.W.228.231; 1.W.228.236; 1.W.228.237;
1.W.228.238;1.W.228.239;1.W.228.154;1.W.228.157;1.W.228.166;1.W.228.169;
1.W.228.172; 1.W.228.175; 1.W.228.240; 1.W.228.244; 1.W.229.228; 1.W.229.229;
1.W.229.230; 1.W.229.231; 1.W.229.236; 1.W.229.237; 1.W.229.238; 1.W.229.239;
1.W.229.154; 1.W.229.157; 1.W.229.166; 1.W.229.169; 1.W.229.172; 1.W.229.175;
1.W.229.240; 1.W.229.244; 1.W.230.228; 1.W.230.229; 1.W.230.230;1.W.230.231;
1.W.230.236;1.W.230.237; 1.W.230.238; 1.W.230.239; 1.W.230.154; 1.W.230.157;
1.W.230.166; 1.W.230.169; 1.W.230.172; 1.W.230.175; 1.W.230.240;1.W.230.244;
1.W.231.228; 1.W.231.229; 1.W.231.230; 1.W.231.231; 1.W.231.236; 1.W.231.237;
1.W.231.238; 1.W.231.239; 1.W.231.154; 1.W.231.157; 1.W.231.166; 1.W.231.169;
1.W.231.172; 1.W.231.175; 1.W.231.240; 1.W.231.244; 1.W.236.228;1.W.236.229;
1.W.236.230; 1.W.236.231; 1.W.236.236; 1.W.236.237; 1.W.236.238; 1.W.236.239;

1.W.236.154; 1.W.236.157; 1.W.236.166; 1.W.236.169; 1.W.236.172; 1.W.236.175;
1.W.236.240;1.W.236.244;1.W.237.228; 1.W.237.229; 1.W.237.230;1.W.237.231;
1.W.237.236; 1.W.237.237; 1.W.237.238; 1.W.237.239; 1.W.237.154; 1.W.237.157;
1.W.237.166; 1.W.237.169; 1.W.237.172; 1.W.237.175; 1.W.237.240; 1.W.237.244;
1.W.238.228;1.W.238.229; 1.W.238.230; 1.W.238.231; 1.W.238.236;1.W.238.237;
1.W.238.238; 1.W.238.239;1.W.238.154; 1.W.238.157; 1.W.238.166;1.W.238.169;
1.W.238.172; 1.W.238.175; 1.W.238.240; 1.W.238.244; 1.W.239.228; 1.W.239.229;
1.W.239.230; 1.W.239.231; 1.W.239.236; 1.W.239.237; 1.W.239.238; 1.W.239.239;
1.W.239.154;1.W.239.157; 1.W.239.166; 1.W.239.169; 1.W.239.172;1.W.239.175;
1.W.239.240;1.W.239.244; 1.W.154.228; 1.W.154.229; 1.W.154.230; 1.W.154.231;
1.W.154.236; 1.W.154.237; 1.W.154.238; 1.W.154.239; 1.W.154.154; 1.W.154.157;
1.W.154.166;1.W.154.169;1.W.154.172; 1.W.154.175;1.W.154.240;1.W.154.244;
1.W.157.228; 1.W.157.229; 1.W.157.230; 1.W.157.231; 1.W.157.236; 1.W.157.237;
1.W.157.238; 1.W.157.239; 1.W.157.154; 1.W.157.157; 1.W.157.166; 1.W.157.169;
1.W.157.172; 1.W.157.175; 1.W.157.240; 1.W.157.244; 1.W.166.228; 1.W.166.229;
1.W.166.230;1.W.166.231; 1.W.166.236;1.W.166.237;1.W.166.238;1.W.166.239;
1.W.166.154;1.W.166.157; 1.W.166.166; 1.W.166.169; 1.W.166.172; 1.W.166.175;
1.W.166.240; 1.W.166.244; 1.W.169.228; 1.W.169.229; 1.W.169.230; 1.W.169.231;
1.W.169.236; 1.W.169.237; 1.W.169.238; 1.W.169.239; 1.W.169.154; 1.W.169.157;
1.W.169.166; 1.W.169.169; 1.W.169.172; 1.W.169.175; 1.W.169.240; 1.W.169.244;
1.W.172.228; 1.W.172.229; 1.W.172.230; 1.W.172.231; 1.W.172.236; 1.W.172.237;
1.W.172.238; 1.W.172.239; 1.W.172.154; 1.W.172.157; 1.W.172.166; 1.W.172.169;
1.W.172.172; 1.W.172.175; 1.W.172.240; 1.W.172.244; 1.W.175.228; 1.W.175.229;
1.W.175.230; 1.W.175.231; 1.W.175.236; 1.W.175.237; 1.W.175.238; 1.W.175.239;
1.W.175.154; l.W.175.157; 1.W.175.166; 1.W.175.169; 1.W.175.172; 1.W.175.175;
1.W.175.240;1.W.175.244; 1.W.240.228; 1.W.240.229; 1.W.240.230; l.W.240.231;
1.W.240.236; 1.W.240.237; 1.W.240.238; 1.W.240.239; 1.W.240.154; 1.W.240.157;
1.W.240.166; 1.W.240.169; 1.W.240.172; 1.W.240.175; 1.W.240.240; 1.W.240.244;
1.W.244.228; 1.W.244.229; 1.W.244.230; 1.W.244.231; 1.W.244.236; 1.W.244.237;
1.W.244.238; 1.W.244.239;1.W.244.154; 1.W.244.157; 1.W.244.166; 1.W.244.169;
1.W.244.172; 1.W.244.175; 1.W.244.240; 1.W.244.244;

Prodrugs of 1.Y
1.Y.228.228; 1.1.228.229; 1.Y.228.230; 1.Y.228.231; 1.1.228.236; 1.Y.228.237;
1.Y.228.238; 1.Y.228.239; 1.Y.228.154; 1.Y.228.157; 1_Y.228.166; 1.1.228.169;
1.1.228.172; 1.Y.228.175; 1.1.228.240; 1.Y.228.244;1.Y.229.228; 1.Y.229.229;
1.Y.229.230;1.Y.229.231; 1.Y.229.236; 1.Y.229.237; 1.Y.229.238; 1.Y.229.239;
1.1.229.154; 1.Y.229.157; 1.Y.229.166; 1.Y.229.169; 1.1.229.172; 1.1.229.175;
1.Y.229.240;1.Y.229.244; 1.Y.230.228; 1.Y.230.229; 1.Y.230.230; 1.1.230.231;
1.1.230.236; 1.Y.230.237; 1.Y.230.238; 1.Y.230.239; 1.Y.230.154; 1.Y.230.157;
1.Y.230.166; 1.Y.230.169; 1.Y.230.172; 1.Y.230.175; 1.Y.230.240; 1.1_230.244;
1.Y.231.228;1.Y.231.229; 1.Y_231.230; 1.Y.231.231;1.Y.231.236; 1.1.231.237;
1.Y.231.238; 1.Y.231.239; 1.Y.231.154; 1.Y.231.157;1.Y.231.166; 1.1.231.169;
1.1.231.172; 1.Y.231.175; 1.Y.231.240; 1.Y.231.244;1.Y.236_228; 1.1.236.229;
1.Y.236.230; 1.1.236.231; 1.Y.236.236; 1.Y.236.237;1.Y.236.238; 1.Y.236.239;
1.Y.236.154; 1.Y.236.157; 1.1.236.166; 1.Y.236.169;1.Y.236.172; 1.1.236.175;
1.1.236.240; 1.Y.236.244; 1.Y.237.228; 1.Y.237.229;1.Y.237.230; 1.Y.237.231;
1.1.237.236; 1.Y.237.237;1.1.237.238; 1.Y.237.239; 1.Y.237.154; 1.1.237.157;
1.Y.237.166;1.Y.237.169; 1.Y.237.172; 1.Y.237.175; 1.Y.237.240; 1.Y.237.244;
1.1.238.228; 1.Y.238.229; 1.1.238.230; 1.Y.238.231; 1.Y.238.236; 1.Y.238.237;
1.Y.238.238; 1.Y.238.239; 1.1_238.154; 1.Y.238.157; 1.Y.238.166; 1.1.238.169;
1.1.238.172; 1.Y.238.175; 1.1.238.240; 1.Y.238.244; 1.Y.239.228; 1.Y.239.229;
1.Y.239.230; 1.Y.239.231; 1.Y.239.236; 1.Y.239.237; 1.Y.239.238; 1.1.239.239;
1.Y.239.154; 1.Y.239.157; 1.Y.239.166; 1.Y.239.169; 1.1.239.172; 1.1.239.175;
1.Y.239.240; 1.Y.239.244; 1.Y.154.228; 1.Y.154.229; 1.1.154.230; 1.1.154.231;
1.1.154.236; 1.Y.154.237; 1.1.154.238; 1.Y.154.239; 1.Y.154.154; 1.Y.154.157;
1.1.154.166; 1.Y.154.169; 1.1.154.172; 1.Y.154.175; 1.Y.154.240; 1.1.154.244;
1.1.157.228; 1.Y.157.229; 1.Y.157.230; 1.Y.157.231; 1.Y.157.236; 1.Y.157.237;
1.Y.157.238; 1.Y.157.239; 1.Y.157.154; 1.Y.157.157; 1.1.157.166; 1.1.157.169;
1.1.157.172;1.Y.157.175; 1.Y.157.240; 1.Y.157.244; 1.Y.166.228; 1.1.166.229;
1.Y.166.230; 1.Y.166.231; 1.Y.166.236; 1.Y.166.237; 1.1.166.238; 1.1.166.239;
1.Y.166.154; 1.1.166.157; 1.Y.166.166; 1.Y.166.169; 1.Y.166.172; 1.Y.166.175;

1.Y.166.240; 1.Y.166.244; 1.1.169.228; 1.Y.169.229; 1.1.169.230; 1.Y.169.231;
1.Y.169.236; 1.Y.169.237; 1.Y.169.238; 1.1.169.239; 1.Y.169.154; 1.Y.169.157;
1.Y.169.166; 1.Y.169.169; 1.Y.169.172; 1.Y.169.175; 1.1.169.240; 1.Y.169.244;
1.1.172.228; 1.Y.172.229; 1.Y.172.230; 1.1.172.231; 1.Y.172.236; 1.Y.172.237;
1.1.172.238; 1.Y.172.239; 1.1.172.154; 1.Y.172.157; 1.Y.172.166; 1.1.172.169;
1.Y.172.172; 1.Y.172.175; 1.Y.172.240; 1.Y.172.244; 1.Y.175.228; 1.Y.175.229;
1.Y.175.230; 1.Y.175.231; 1.1.175.236; 1.Y.175.237; 1.1.175.238; 1.Y.175.239;
1.Y.175.154; 1.1.175.157; 1.Y.175.166; 1.Y.175.169; 1.Y.175.172; 1.1.175.175;
1.Y.175.240; 1.Y.175.244; 1.1.240.228; 1.Y.240.229; 1.1.240.230; 1.Y.240.231;
1.Y.240.236; 1.Y.240.237; 1_Y.240.238; 1.Y.240.239;.1.1.240.154; 1.Y.240.157;
1.Y.240.166; 1.Y.240.169; 1.Y.240.172; 1.Y.240.175; 1.Y.240.240; 1.1.240.244;
1.Y.244.228; 1.1.244.229; 1.Y.244.230; 1.Y.244.231; 1.1.244.236; 1.Y.244.237;
1.1.244.238; 1.Y.244.239; 1.Y.244.154; 1.Y.244.157; 1.Y.244.166; 1.Y.244.169;
1.Y.244.172; 1.1.244.175; 1.Y.244.240; 1.1.244.244;

Prodrugs of 2.B
2.B.228.228; 2.B.228.229; 2.B.228.230; 2.B.228.231; 2.B.228.236; 2.B.228.237;
2.B.228.238; 2.B.228.239; 2.B.228.154; 2.B.228.157; 2.B.228.166; 2.B.228.169;
2.B.228.172; 2.B.228.175; 2.B.228.240; 2.B.228.244; 2.B.229.228; 2.B.229.229;
2.B.229.230; 2.B.229.231; 2.B.229.236; 2.B.229.237; 2.B.229.238; 2.B.229.239;
2.B.229.154; 2.B.229.157; 2.B.229.166; 2.B.229.169; 2.B.229.172; 2.B.229.175;
2.B.229.240; 2.B.229.244; 2.B.230.228; 2.B.230.229; 2.B.230.230; 2.B.230.231;
2.B.230.236; 2.B.230.237; 2.B.230.238; 2.B.230.239; 2.B.230.154; 2.B.230.157;
2.B.230.166; 2.B.230.169; 2.B.230.172; 2.B.230.175; 2.B.230.240; 2.B.230.244;
2.B.231.228; 2.B.231.229; 2.B.231.230; 2.B.231.231; 2.B.231.236; 2.B.231.237;
2.B.231.238; 2.B.231.239; 2.B.231.154; 2.B.231.157; 2.B.231.166; 2.B.231.169;
2.B.231.172; 2.B.231.175; 2.B.231.240; 2.B.231.244; 2.B.236.228; 2.B.236.229;
2.B.236.230; 2.B.236.231; 2.B.236.236; 2.B.236.237; 2.B.236.238; 2.B.236.239;
2.B.236.154; 2.B.236.157; 2.B.236.166; 2.B.236.169; 2.B.236.172; 2.B.236.175;
2.B.236.240; 2.B.236.244; 2.B.237.228; 2.B.237.229; 2.B.237.230; 2.B.237.231;
2.B.237.236; 2.B.237.237; 2.B.237.238; 2.B.237.239; 2.B.237.154; 2.B.237.157;

2.B.237.166; 2.B.237.169; 2.B.237.172; 2.B.237.175; 2.B.237.240; 2.B.237.244;
2.B.238.228; 2.B.238.229; 2.B.238.230; 2.B.238.231; 2.B.238.236; 2.B.238.237;
2.B.238.238; 2.B.238.239; 2.B.238.154; 2.B.238.157; 2.B.238.166; 2.B.238.169;
2.B.238.172; 2.B.238.175; 2.B.238.240; 2.B.238.244; 2.B.239.228; 2.B.239.229;
2.B.239.230; 2.B.239.231; 2.B.239.236; 2.B.239.237; 2.B.239.238; 2.B.239.239;
2.B.239.154; 2.B.239.157; 2.B.239.166; 2.B.239.169; 2.B.239.172; 2.B.239.175;
2.B.239.240; 2.B.239.244; 2.B.154.228; 2.B.154.229; 2.B.154.230; 2.B.154.231;
2.B.154.236; 2.B.154.237; 2.B.154.238; 2.B.154.239; 2.B.154.154; 2.B.154.157;
2.B.154.166; 2.B.154.169; 2.B.154.172; 2.B.154.175; 2.B.154.240; 2.B.154.244;
2.B.157.228; 2.B.157.229; 2.B.157.230; 2.B.157.231; 2.B.157.236; 2.B.157.237;
2.B.157.238; 2.B.157.239; 2.B.157.154; 2.B.157.157; 2.B.157.166; 2.B.157.169;
2.B.157.172; 2.B.157.175; 2.B.157.240; 2.B.157.244; 2.B.166.228; 2.B.166.229;
2.B.166.230; 2.B.166.231; 2.B.166.236; 2.B.166.237; 2.B.166.238; 2.B.166.239;
2.B.166.154; 2.B.166.157; 2.B.166.166; 2.B.166.169; 2.B.166.172; 2.B.166.175;
2.B.166.240; 2.B.166.244; 2.B.169.228; 2.B.169.229; 2.B.169.230; 2.B.169.231;
2.B.169.236; 2.B.169.237; 2.B.169.238; 2.B.169.239; 2.B.169.154; 2.B.169.157;
2.B.169.166; 2.B.169.169; 2.B.169.172; 2.B.169.175; 2.B.169.240; 2.B.169.244;
2.B.172.228; 2.B.172.229; 2.B.172.230; 2.B.172.231; 2.B.172.236; 2.B.172.237;
2.B.172.238; 2.B.172.239; 2.B.172.154; 2.B.172.157; 2.B.172.166; 213.172.169;
2.B.172.172; 2.B.172.175; 2.B.172.240; 2.B.172.244; 2.B.175.228; 2.B.175.229;
2.B.175.230; 2.B.175.231; 2.B.175.236; 2.B.175.237; 2.B.175.238; 2.B.175.239;
2.B.175.154; 2.B.175.157; 2.B.175.166; 2.B.175.169; 2.B.175.172; 2.B.175.175;
2.B.175.240; 2.B.175.244; 2.B.240.228; 2.B.240.229; 2.B.240.230; 2.B.240.231;
2.B.240.236; 2.B.240.237; 2.B.240.238; 2.B.240.239; 2.B.240.154; 2.B.240.157;
2.B.240.166; 2.B.240.169; 2.B.240.172; 2.B.240.175; 2.B.240.240; 2.B.240.244;
2.B.244.228;.2.B.244.229; 2.B.244.230; 2.B.244.231; 2.B.244.236; 2.B.244.237;
2.B.244.238; 2.B.244.239; 2.B.244.154; 2.B.244.157; 2.B.244.166; 2.B.244.169;
2.B.244.172; 2.B.244.175; 2.B.244.240; 2.B.244.244;

Prodrugs of 2.D

2.D.228.228; 2.D.228.229; 2.D.228.230; 2Ø228.231; 2.D.228.236; 2Ø228.237;
2.D.228.238; 2.D.228.239; 2.D.228.154; 2.D.228.157; 2.D.228.166; 2Ø228.169;
2.D.228.172; 2.D.228.175; 2.D.228.240; 2.D.228.244; 2.D.229.228; 2.D.229.229;
2.D.229.230; 2.D.229.231; 2.D.229.236; 2.D.229.237; 2.D.229.238; 2.D.229.239;
2.D.229.154; 2.D.229.157; 2.D.229.166; 2.D.229.169; 2.D.229.172; 2.D.229.175;
2.D.229.240; 2.D.229.244; 2.D.230.228; 2.D.230.229; 2.D.230.230; 2.D.230.231;
2.D.230.236; 2.D.230.237; 2.D.230.238; 2.D.230.239; 2.D.230.154; 2.D.230.157;
2.D.230.166; 2Ø230.169; 2Ø230.172; 2Ø230.175; 2.D.230.240; 2.D.230.244;
2.D.231.228; 2.D.231.229; 2.D.231.230; 2.D.231.231; 2.D.231.236; 2.D.231.237;
2.D.231.238; 2.D.231.239; 2.D.231.154; 2.D.231.157; 2.D.231.166; 2.D.231.169;
2.D.231.172; 2.D.231.175; 2.D.231.240; 2.0_231.244; 2.D.236.228; 2.D.236.229;
2.D.236.230; 2.D.236.231; 2Ø236.236; 2.D.236.237; 2.D.236.238; 2.D.236.239;
2.D.236.154; 2.D.236.157; 2.D.236.166; 2.D.236.169; 2.D.236.172; 2.D.236.175;
2.D.236.240; 2.D.236.244; 2.D.237.228; 2.D.237.229; 2.D.237.230; 2.D.237.231;
2.D.237.236; 2.D.237.237; 2.D.237.238; 2.D.237.239; 2.D.237.154; 2.D.237.157;
2.D.237.166; 2.D.237.169; 2.D.237.172; 2.D.237.175; 2Ø237.240; 2.D.237.244;
2.D.238.228; 2.D.238.229; 2.D.238.230; 2.D.238.231; 2Ø238.236; 2.D.238.237;
2.D.238.238; 2.D.238.239; 2.D.238.154; 2.D.238.157; 2.D.238.166; 2.D.238.169;
2.D.238.172; 2.D.238.175; 2.D.238.240; 2.D.238.244; 2.D.239.228; 2.D.239.229;
2.D.239.230; 2.D.239.231; 2.D.239.236; 2.D.239.237; 2.D.239.238; 2Ø239.239;
2.D.239.154; 2.D.239.157; 2.D.239.166; 2.D.239.169; 2.D.239.172; 2.D.239.175;
2.D.239.240; 2.D.239.244; 2.D.154.228; 2.D.154.229; 2.D.154.230; 2Ø154.231;
2.D.154.236; 2.D.154.237; 2.D.154.238; 2.D.154.239; 2.D.154.154; 2.D.154.157;
2.D.154.166; 2.D.154.169; 2.D.154.172; 2.D.154.175; 2.D.154.240; 2.D.154.244;
2.D.157.228; 2.D.157.229; 2.D.157.230; 2.D.157.231; 2.D.157.236; 2.D.157.237;
2.D.157.238; 2.D.157.239; 2.D.157.154; 2.D.157.157; 2.D.157.166; 2.D.157.169;
2.D.157.172; 2.D.157.175; 2.D.157.240; 2.D.157.244; 2.D.166.228; 2.D.166.229;
2.D.166.230; 2.D.166.231; 2.D.166.236; 2.D.166.237; 2.D.166.238; 2.D.166.239;
2.D.166.154; 2.D.166.157; 2.D.166.166; 2.D.166.169; 2.D.166.172; 2.D.166.175;
2.D.166.240; 2.D.166.244; 2.D.169.228; 2.D.169.229; 2.D.169.230; 2.D.169.231;
2.D.169.236; 2.D.169.237; 2.D.169.238; 2Ø169.239; 2.D.169.154; 2.D.169.157;

2.D.169.166; 2.D.169.169; 2.D.169.172; 2.D.169.175; 2.D.169.240; 2.D.169.244;
2.D.172.228; 2.D.172.229; 2.D.172.230; 2.D.172.231; 2.D.172.236; 2.D.172.237;
2.D.172.238; 2.D.172.239; 2.D.172.154; 2.D.172.157; 2.D.172.166; 2.D.172.169;
2.D.172.172; 2.D.172.175; 2.D.172.240; 2.D.172.244; 2.D.175.228; 2.D.175.229;
2.D.175.230; 2.D.175.231; 2.D.175.236; 2.D.175.237; 2.D.175.238; 2.D.175.239;
.10 2.D.175.154; 2.D.175.157; 2.D.175.166; 2.D.175.169; 2.D.175.172;
2.D.175.175;
2.D.175.240; 2.D.175.244; 2.D.240.228; 2.D.240.229; 2.D.240.230; 2.D.240.231;
2.D.240.236; 2.D.240.237; 2.D.240.238; 2.D.240.239; 2.D.240.154; 2.D.240.157;
2.D.240.166; 2.D.240.169; 2.D.240.172; 2.D.240.175; 2.D.240.240; 2.D.240.244;
2.D.244.228; 2.D.244.229; 2.D.244.230; 2.D.244.231; 2.D.244.236; 2.D.244.237;
2.D.244.238; 2.D.244_239; 2.D.244.154; 2.D.244.157; 2.D.244.166; 2.D.244.169;
2.D.244.172; 2.D.244.175; 2.D.244.240; 2.D.244.244;

Prodrugs of 2.E
2.E.228.228; 2.E.228.229; 2.E.228.230; 2.E.228.231; 2.E.228.236; 2.E.228.237;
2.E.228.238; 2.E.228.239; 2.E228.154; 2.E.228.157; 2.E.228.166; 2.E.228.169;
2.E.228.172; 2.E.228.175; 2.E.228.240; 2.E.228.244; 2.E.229.228; 2.E.229.229;
2.E.229.230; 2.E.229.231; 2.E.229.236; 2.E.229.237; 2.E.229.238; 2.E.229.239;
2.E.229.154; 2.E.229.157; 2.E.229.166; 2.E.229.169; 2.E.229.172; 2.E.229.175;
2.E.229.240; 2.E.229.244; 2.E.230.228; 2.E.230.229; 2.E.230.230; 2.E.230.231;
2.E.230.236; 2.E.230.237; 2.E.230.238; 2.E.230.239; 2.E.230.154; 2:E.230.157;
2.E.230.166; 2.E.230.169; 2.E.230.172; 2.E.230.175; 2.E.230.240; 2.E.230.244;
2.E.231.228; 2.E.231.229; 2.E.231.230; 2.E.231.231; 2.E.231.236; 2.E.231.237;
2.E.231.238; 2.E.231.239; 2.E.231.154; 2.E.231.157; 2.E.231.166; 2.E.231.169;
2.E.231.172; 2.E.231.175; 2.E.231.240; 2.E.231.244; 2.E.236.228; 2.E.236.229;
2.E.236.230; 2.E.236.231; 2.E.236.236; 2.E.236.237; 2.E.236.238; 2.E.236.239;
2.E.236.154; 2.E.236.157; 2.E.236.166; 2.E.236.169; 2.E.236.172; 2.E.236.175;
2.E.236.240; 2.E.236.244; 2.E.237.228; 2.E.237.229; 2.E.237.230; 2.E.237.231;
2.E.237.236; 2.E.237.237; 2.E.237.238; 2.E.237.239; 2.E.237.154; 2.E.237.157;
2_E.237.166; 2.E.237.169; 2.E.237.172; 2.E.237.175; 2.E.237.240; 2.E.237.244;
2.E.238.228; 2.E.238.229; 2.E.238.230; 2.E.238.231; 2.E.238.236; 2.E.238.237;

2.E.238.238; 2.E.238.239; 2.E.238.154; 2.E.238.157; 2.E.238.166; 2.E.238.169;
2.E.238.172; 2.E.238.175; 2.E.238.240; 2.E.238.244; 2.E.239.228; 2.E.239.229;
2.E.239.230; 2.E.239.231; 2.E.239.236; 2.E.239.237; 2.E.239.238; 2.E.239.239;
2.E.239.154; 2.E.239.157; 2.E.239.166; '2.E.239.169; 2.E.239.172; 2.E.239.175;
2.E.239.240; 2.E.239.244; 2.E.154.228; 2.E.154.229; 2.E.154.230; 2.E.154.231;
2.E.154.236; 2.E.154.237; 2.E.154.238; 2.E.154.239; 2.E.154.154; 2.E.154.157;
2.E.154.166; 2.E.154.169; 2.E.154.172; 2.E.154.175; 2.E.154.240; 2.E.154.244;
2.E.157.228; 2.E.157.229; 2.E.157.230; 2.E.157.231; 2.E.157.236; 2.E.157.237;
2.E.157.238; 2.E.157.239; 2.E.157.154; 2.E.157.157; 2.E.157.166; 2.E.157.169;
2.E.157.172; 2.E.157.175; 2.E.157.240; 2.E.157.244; 2.E.166.228; 2.E.166.229;
2.E.166.230; 2.E.166.231; 2.E.166.236; 2.E.166.237; 2.E.166.238; 2.E.166.239;
2.E.166.154; 2.E.166.157; 2.E.166.166; 2.E.166.169; 2.E.166.172; 2.E.166.175;
2.E.166.240; 2.E.166.244; 2.E.169.228; 2.E.169.229; 2.E.169.230; 2.E.169.231;
2.E.169.236; 2.E.169.237; 2.E.169.238; 2.E.169.239; 2.E.169.154; 2.E.169.157;
2.E.169.166; 2.E.169.169; 2.E.169.172; 2.E.169.175; 2.E.169.240; 2.E.169.244;
2.E.172.228; 2.E.172.229; 2.E.172.230; 2.E.172.231; 2.E.172.236; 2.E.172.237;
2.E.172.238; 2.E.172.239; 2.E.172.154; 2.E.172.157; 2.E.172.166; 2.E.172.169;
2.E.172.172; 2.E.172.175; 2.E.172.240; 2.E.172.244; 2.E.175.228; 2.E.175.229;
2.E.175.230; 2.E.175.231; 2.E.175.236; 2.E.175.237; 2.E.175.238; 2.E.175.239;
2.E.175.154; 2.E.175.157; 2.E.175.166; 2.E.175.169; 2.E.175.172; 2.E.175.175;
2.E.175.240; 2.E.175.244; 2.E.240.228; 2.E.240.229; 2.E.240.230; 2.E.240.231;
2.E.240.236; 2.E.240.237; 2.E.240.238; 2.E.240.239; 2.E.240.154; 2.E.240.157;
2.E.240.166; 2.E.240.169; 2.E.240.172; 2.E.240.175; 2.E.240.240; 2.E.240.244;
2.E.244.228; 2.E.244.229; 2.E.244.230; 2.E.244.231; 2.E.244.236; 2.E.244.237;
2.E.244.238; 2.E.244.239; 2.E.244.154; 2.E.244.157; 2.E.244.166; 2.E.244.169;
2.E.244.172; 2.E.244.175; 2.E.244.240; 2.E.244.244;

Prodrugs of 2.G
2.G.228.228; 2.G.228.229; 2.G.228.230; 2.G.228.231; 2.G.228.236; 2.G.228.237;
2.G.228.238; 2.G.228.239; 2.G.228.154; 2.G.228.157; 2.G.228.166; 2.G.228.169;
2.G.228.172; 2.G.228.175; 2.G.228.240; 2.G.228.244; 2.G.229.228; 2.G.229.229;

2.G.229.230; 2.G.229.231; 2.G.229.236; 2.G.229.237; 2.G.229.238; 2.G.229.239;
2.G.229.154; 2.G.229.157; 2.G.229.166; 2.G.229.169; 2.G.229.172; 2.G.229.175;
2.G.229.240; 2.G.229.244; 2.G.230.228; 2.G.230.229; 2.G.230.230; 2.G.230.231;
2.G.230.236; 2.G.230.237; 2.G.230.238; 2.G.230.239; 2.G.230.154; 2.G.230.157;
2.G.230.166; 2.G.230.169; 2.G.230.172; 2.G.230.175; 2.G.230.240; 2.G.230.244;
2.G.231.228; 2.G.231.229; 2.G.231.230; 2.G.231.231; 2.G.231.236; 2.G.231.237;
2.G.231.238; 2.G.231.239; 2.G.231.154; 2.G.231.157; 2.G.231.166; 2.G.231.169;
2.G.231.172; 2.G.231.175; 2.G.231.240; 2.G.231.244; 2.G.236.228; 2.G.236.229;
2.G.236.230; 2.G.236.231; 2.G.236.236; 2.G.236.237; 2.G.236.238; 2.G.236.239;
2.G.236.154; 2.G.236.157; 2.G.236.166; 2.G.236.169; 2.G.236.172; 2.G.236.175;
2.G.236.240; 2.G.236.244; 2.G.237.228; 2.G.237.229; 2.G.237.230; 2.G.237.231;
2.G.237.236; 2.G.237.237; 2.G.237.238; 2.G.237.239; 2.G.237.154; 2.G.237.157;
2.G.237.166; 2.G.237.169; 2.G.237.172; 2.G.237.175; 2.G.237.240; 2.G.237.244;
2.G.238.228; 2.G.238.229; 2.G.238.230; 2.G.238.231; 2.G.238.236; 2.G.238.237;
2.G.238.238; 2.G.238.239; 2.G.238.154; 2.G.238.157; 2.G.238.166; 2.G.238.169;
2.G.238.172; 2.G.238.175; 2.G.238.240; 2.G.238.244; 2.G.239.228; 2.G.239.229;
-2.G.239.230; 2.G.239.231; 2.G.239.236; 2.G.239.237; 2.G.239.238; 2.G.239.239;
2.G.239.154; 2.G.239.157; 2.G.239.166; 2.G.239.169; 2.G.239.172; 2.G.239.175;
2.G.239.240; 2.G.239.244; 2.G.154.228; 2.G.154.229; 2.G.154.230; 2.G.154.231;
2.6.154.236; 2.G.154.237; 2.G.154.238; 2.G.154.239; 2.G.154.154; 2.G.154.157;
2.G.154.166; 2.G.154.169; 2.G.154.172; 2.G.154.175; 2.G.154.240; 2.G.154.244;
2.G.157.228; 2.G.157.229; 2.G.157.230; 2.G.157.231; 2.G.157.236; 2.G.157.237;
2.G.157.238; 2.G.157.239; 2.G.157.154; 2.G.157.157; 2.G.157.166; 2.G.157.169;
2.G.157.172; 2.G.157.175; 2.G.157.240; 2.G.157.244; 2.G.166.228; 2.G.166.229;
2.G.166.230; 2.G.166.231; 2.G.166.236; 2.G.166.237; 2.G.166.238; 2.G.166.239;
2.G.166.154; 2.G.166.157; 2.G.166.166; 2.G.166.169; 2.G.166.172; 2.G.166.175;
2.G.166.240; 2.G.166.244; 2.G.169.228; 2.G.169.229; 2.G.169.230; 2.G.169.231;
2.G.169.236; 2.G.169.237; 2.G.169.238; 2.G.169.239; 2.G.169.154; 2.G.169.157;
2.G.169.166; 2.G.169.169; 2.G.169.172; 2.G.169.175; 2.G.169.240; 2.G.169.244;
2.G.172.228; 2.G.172.229; 2.G.172.230; 2.G.172.231; 2.G.172.236; 2.G.172.237;
2.G.172.238; 2.G.172.239; 2.G.172.154; 2.G.172.157; 2.G.172.166; 2.G.172.169;

2.G.172.172; 2.G.172.175; 2.G.172.240; 2.G.172.244; 2.G.175.228; 2.G.175.229;
2.G.175.230; 2.G.175.231; 2.G.175.236; 2.G.175.237; 2.G.175.238; 2.G.175.239;
2.G.175.154; 2.G.175.157; 2.G.175.166; 2.G.175.169; 2.G.175.172; 2.G.175.175;
2.G.175.240; 2.G.175.244; 2.G.240.228; 2.G.240.229; 2.G.240.230; 2.G.240.231;
2.G.240.236; 2.G.240.237; 2.G.240.238; 2.G.240.239; 2.G.240.154; 2.G.240.157;
2.G.240.166; 2.G.240.169; 2.G.240.172; 2.G.240.175; 2.G.240.240; 2.G.240.244;
2.G.244.228; 2.G.244.229; 2.G.244.230; 2.G.244.231; 2.G.244.236; 2.G.244.237;
2.G.244.238; 2.G.244.239; 2.G.244.154; 2.G.244.157; 2.G.244.166; 2.G.244.169;
2.G.244.172; 2.G.244.175; 2.G.244.240; 2.G.244.244;

Prodrugs of 2.1 2.1.228.228; 2.1.228.229; 2.1.228.230; 2.1.228.231; 2.1.228.236; 2.1.228.237;
2.1.228.238; 2.1.228.239; 21228.154; 2.1.228.157; 2.1.228.166; 2.1.228.169;
2.1.228.172;
2.1.228.175; 2.1.228.240; 2.1.228.244; 2.1.229.228; 2.1.229.229; 2.1.229.230;
2.1.229.231;
21229.236; 2.1.229.237; 2.1.229.238; 2.1.229.239; 2.1.229.154; 2.1.229.157;
21229.166;
21229.169; 2.1.229.172; 2.1.229.175; 2.1.229.240; 2.1.229.244; 2.1.230.228;
2.1.230.229;
2.1.230.230; 2.1.230.231; 2.1.230.236; 2.1.230.237; 2.1.230.238; 2.1.230.239;
2.1.230.154;
2.1.230.157; 2.1.230.166; 2.1.230.169; 2.1.230.172; 2.1.230.175; 2.1.230.240;
2.1.230.244;
2.1.231.228; 2.1.231.229; 2.1.231.230; 2.1.231.231; 2.1.231.236; 2.1.231.237;
2.1.231.238;
2.1.231.239; 2.1.231.154; 2.1.231.157; 2.1.231.166; 2.1.231.169; 2.1.231.172;
2.1.231.175;
2.1.231.240; 2.1.231.244; 2.1.236.228; 2.1.236.229; 2.1.236.230; 2.1.236.231;
2.1.236.236;
2.1.236.237; 2.1.236.238; 2.1.236.239; 2.1.236.154; 2.1.236.157; 2.1.236.166;
2.1.236.169;
2.1.236.172; 2.1:236.175; 2.1.236.240; 2.1.236.244; 2.1.237.228; 2.1.237.229;
2.1.237.230;
2.1.237.231; 2.1.237.236; 2.1.237.237; 2.1.237.238; 2.1.237.239; 2.1.237.154;
2.1.237.157;
2.1.237.166; 2.1.237.169; 2.1.237.172; 2.1.237.175; 2.1.237.240; 2.1.237.244;
2.1.238.228;
2.1.238.229; 2.1.238.230; 2.1.238.231; 2.1.238.236; 2.1.238.237; 2.1.238.238;
2.1.238.239;
2.1.238.154; 2.1.238.157; 2.1.238.166; 2.1.238.169; 2.1.238.172; 2.1.238.175;
2.1.238.240;
2.1.238.244; 2.1.239.228; 2.1.239.229; 2.1.239.230; 2.1.239.231; 2.1.239.236;
2.1.239.237;
2.1.239.238; 2.1.239.239; 2.1.239.154; 2.1.239.157; 2.1.239.166; 2.1.239.169;
2.1.239.172;
2.1.239.175; 2.1.239.240; 2.1.239.244; 2.1.154.228; 2.1.154.229; 2.1.154.230;
2.1.154.231;
2.1.154.236; 2.1.154.237; 2.1.154.238; 2.1.154.239; 2.1.154.154; 2.1.154.157;
2.1.154.166;

2.1.154.169; 2.1.154.172; 2.1.154.175; 2.1.154.240; 2.1.154.244; 2.1.157.228;
2.1.157.229;
2.1.157.230; 2.1.157.231; 21157.236; 2.1.157.237; 2.1.157.238; 2.1.157.239;
2.1.157.154;
2.1.157.157; 2.1.157.166; 2.1.157.169; 2.1.157.172; 2.1.157.175; 2.1.157.240;
2.1.157.244;
2.1.166.228; 2.1.166.229; 2.1.166.230; 2.1.166.231; 2.1.166.236; 2.1.166.237;
2.1.166.238;
2.1.166.239; 2.1.166.154; 2.1.166.157; 2.1.166.166; 21166.169; 2.1.166.172;
2.1.166.175;
2.1.166.240; 2.1.166.244; 2.1.169.228; 2.1.169.229; 2.1.169.230; 2.1.169.231;
2.1.169.236;
2.1.169.237; 2.1.169.238; 2.1.169.239; 2.1.169.154; 2.1.169.157; 2.1.169.166;
2.1.169.169;
2.1.169.172; 2.1.169.175; 2.1.169.240; 2.1.169.244; 21172.228; 2.1.172.229;
2.1.172.230;
2.1.172.231; 2.1.172.236; 2.1.172.237; 2.1.172.238; 2.1.172.239; 2.1.172.154;
2.1.172.157;
2.1.172.166; 2.1.172.169; 2.1.172.172; 2.1.172.175; 2.1.172.240; 2.1.172.244;
2.1.175.228;
2.1.175.229; 2.1.175.230; 2.1.175.231; 2.1.175.236; 2.1.175.237; 2.1.175.238;
2.1.175.239;
2.1.175.154; 2.1.175.157; 2.1.175.166; 2.1.175.169; 2.1.175.172; 2.1.175.175;
2.1.175.240;
2.1.175.244; 2.1.240.228; 2.1.240.229; 2.1.240.230; 2.1.240.231; 2.1.240.236;
2.1.240.237;
2.1.240.238; 2.1.240.239; 2.1.240.154; 2.1.240.157; 2.1.240.166; 2.1.240.169;
2.1.240.172;
2.1.240.175; 2.1.240.240; 21240.244; 2.1.244.228; 2.1.244.229; 2.1.244.230;
2.1.244.231;
2.1.244.236; 2.1.244.237; 2.1.244.238; 2.1.244.239; 2.1.244.154; 2.1.244.157;
2.1.244.166;
2.1.244.169; 2.1.244.172; 2.1.244.175; 2.1.244.240; 2.1.244.244;

Prodru s~ of 2.T
2.J.228.228; 2.J.228.229; 2.J.228.230; 2.J.228.231; 2.J.228.236; 2.J.228.237;
2.J.228.238; 2.J.228.239; 2.J.228.154; 2.J.228.157; 2.J.228.166; 2.J.228.169;
2.J.228.172;
2.J.228.175; 2.J.228.240; 2.J.228.244; 2.J.229.228; 2.J.229.229; 2.J.229.230;
2.J.229.231;
2.J.229.236; 2.J.229.237; 2.J.229.238; 2.J.229.239; 2.J.229.154; 2.J.229.157;
2.J.229.166;
2.J.229.169; 2.J.229.172; 2.J.229.175; 2.J.229.240; 2.J.229.244; 2.J.230.228;
2.J.230.229;
2.J.230.230; 2.J.230.231; 2.J.230.236; 2_J.230.237; 2.J.230.238; 2.J.230.239;
2.J.230.154;
2.J.230.157; 2.J.230.166; 2.J.230.169; 2.J.230.172; 2.J.230.175; 2.J.230.240;
2.J.230.244;
2.J.231.228; 2.J.231.229; 2.J.231.230; 2.J.231.231; 2.J.231.236; 2.J.231.237;
2.J.231.238;
2.J.231.239; 2.J.231.154; 2.J.231.157; 2.J.231.166; 2.J.231.169; 2.J.231.172;
2.J.231.175;
2.J.231.240; 2.J.231.244; 2.J.236.228; 2.J.236.229; 2.J.236.230; 2.J.236.231;
2.J.236.236;
2.J.236.237; 2.J.236.238; 2.J.236.239; 2.J.236.154; 2.J.236.157; 2.J.236.166;
2.J.236.169;
2.J.236.172; 2.J.236.175; 2.J.236.240; 2.J.236.244; 2.J.237.228; 2.J.237.229;
2.J.237.230;

2.J.237.231; 2.J.237.236; 2.J.237.237; 2.J.237.238; 2.J.237.239; 2.J.237.154;
2.J.237.157;
2.J.237.166; 2.J.237.169; 2.J.237.172; 2.J.237.175; 2.J.237.240; 2.J.237.244;
2.J.238.228;
2.J.238.229; 2.J.238.230; 2.J.238.231; 2.J.238.236; 2.J.238.237; 2.J.238.238;
2.J.238.239;
2.J.238.154; 2.J.238.157; 2.J.238.166; 2.J.238.169; 2.J.238.172; 2.J.238.175;
2.J.238.240;
2.J.238.244; 2.J.239.228; 2.J.239.229; 2.J.239.230; 2.J.239.231; 2.J.239.236;
2:J.239.237;
2.J.239.238; 2.J.239.239; 2.J.239.154; 2.J.239.157; 2.J.239.166; 2.J.239.169;
2.J.239.172;
2.J.239.175; 2.J.239.240; 2.J.239.244; 2.J.154.228; 2.J.154.229; 2.J.154.230;
2.J.154.231;
2.J.154.236; 2.J.154.237; 2.J.154.238; 2.J.154.239; 2.J.154.154; 2.J.154.157;
2.J.154.166;
2.J.154.169; 2.J.154.172; 2.J.154.175; 2.J.154.240; 2.J.154.244; 2.J.157.228;
2.J.157.229;
2.J.157.230; 2.J.157.231; 2.J.157.236; 2.J.157.237; 2.J.157.238; 2.J.157.239;
2.J.157.154;
2.J.157.157; 2.J.157.166; 2.J.157.169; 2.J.157.172; 2.J.157.175; 2.J.157.240;
2.J.157.244;
2.J.166.228; 2.J.166.229; 2.J.166.230; 2.J.166.231; 2.J.166.236; 2.J.166.237;
2.J.166.238;
2.J.166.239; 2.J.166.154; 2.J.166.157; 2.J.166.166; 2.J.166.169; 2.J.166.172;
2.J.166.175;
2.J.166.240; 2.J.166.244; 2.J.169.228; 2.J.169.229; 2.J.169.230; 2.J.169.231;
2.J.169.236;
2.J.169.237; 2.J.169.238; 2.J_169.239; 2.J.169.154; 2.J.169.157; 2.J.169.166;
2.J.169.169;
2.J.169.172; 2.J.169.175; 2.J.169.240; 2.J.169.244; 2.J.172.228; 2.J.172.229;
2.J.172.230;
2.J.172.231; 2.J.172.236; 2.J.172.237; 2.J.172.238; 2.J.172.239; 2.J.172.154;
2.J.172.157;
2.J.172.166; 2.J.172.169; 2.J_172.172; 2.J.172.175; 2.J.172.240; 2.J.172.244;
2.J.175.228;
2.J.175.229; 2.J.175.230; 2.J.175.231; 2.J.175.236; 2.J.175.237; 2:J.175.238;
2.J.175.239;
2.J.175.154; 2.J.175.157; 2.J.175.166; 2.J.175.169; 2.J.175.172; 2.J.175.175;
2.J.175.240;
2.J.175.244; 2.J.240.228; 2.J.240.229; 2.J.240.230; 2.J.240.231; 2.J.240.236;
2.J.240.237;
2.J.240.238; 2.J.240.239; 2.J.240.154; 2.J.240.157; 2.J.240.166; 2.J.240.169;
2.J.240.172;
2.J.240.175; 2.J.240.240; 2.J.240.244; 2.J.244.228; 2.J.244.229; 2.J.244.230;
2.J.244.231;
2.J.244.236; 2.J.244.237; 2.J.244.238; 2.J.244.239; 2.J.244.154; 2.J.244.157;
2.J.244.166;
2.J.244.169; 2.J.244.172; 2.J.244.175; 2.J.244.240; 2.J.244.244;
Prodrugs of 2.L
2.L.228.228; 2.L.228.229; 2.L.228.230; 2.L.228.231; 2.L.228.236; 2.L.228.237;
2.L.228.238; 2.L.228.239; 2.L.228.154; 2.L.228.157; 2.L.228.166; 2.L.228.169;
2.L.228.172; 2.L.228.175; 2.L.228.240; 2.L.228.244; 2.L.229.228; 2.L.229.229;
'35 2.L.229.230; 2.L.229.231; 2.L.229.236; 2.L.229.237; 2.L.229.238;
2.L.229.239;

2.L.229.154; 2.L.229.157; 2.L.229.166; 2.L.229.169; 2.L.229.172; 2.L.229.175;
2.L.229.240; 2.L.229.244; 2.L.230.228; 2.L.230.229; 2.L.230.230; 2.L.230.231;
2.L.230.236; 2.L.230.237; 2.L.230.238; 2.L.230.239; 2.L.230.154; 2.L.230.157;
2.L.230.166; 2.L.230.169; 2.L.230.172; 2.L.230.175; 2.L.230.240; 2.L.230.244;
2.L.231.228; 2.L.231.229; 2.L.231.230; 2.L.231.231; 2.L.231.236; 2.L.231.237;
2.L.231.238; 2.L.231.239; 2.L.231.154; 2.L.231.157; 2.L.231.166; 2.L.231.169;
2.L.231.172; 2.L.231.175; 2.L.231.240; 2.L.231.244; 2.L.236.228; 2.L.236.229;
2.L.236.230; 2.L.236.231; 2.L.236.236; 2.L.236.237; 2.L.236.238; 2.L.236.239;
2.L.236.154; 2.L.236.157; 2.L.236.166; 2.L.236.169; 2.L.236.172; 2.L.236.175;
2.L.236.240; 2.L.236.244; 2.L.237.228; 2.L.237.229; 2.L.237.230; 2.L.237.231;
2.L.237.236; 2.L.237.237; 2.L.237.238; 2.L.237.239; 2.L.237.154; 2.L.237.157;
2.L.237.166; 2.L.237.169; 2.L.237.172; 2.L.237.175; 2.L.237.240; 2.L.237.244;
2.L.238.228; 2.L.238.229; 2.L.238.230; 2.L.238.231; 2.L.238.236; 2.L.238.237;
2.L.238.238; 2.L.238.239; 2.L.238.154; 2.L.238.157; 2.L.238.166; 2.L.238.169;
2.L.238.172; 2.L.238.175; 2.L.238.'240; 2.L.238.244; 2.L.239.228; 2.L.239.229;
2.L.239.230; 2.L.239.231; 2.L.239.236; 2.L.239.237; 2.L.239.238; 2.L.239.239;
2.L.239.154; 2.L.239.157; 2.L.239.166; 2.L.239.169; 2.L.239.172; 2.L.239.175;
2.L.239.240; 2.L.239.244; 2.L.154.228; 2.L.154.229; 2.L.154.230; 2.L.154.231;
2.L.154.236; 2.L.154.237; 2.L.154.238; 2.L.154.239; 2.L.154.154; 2.L.154:157;
2.L.154.166; 2.L.154.169; 2.L.154.172; 2.L.154.175; 2.L.154.240; 2.L.154.244;
2.L.157.228; 2.L.157.229; 2.L.157.230; 2.L.157.231; 2.L.157.236; 2.L.157.237;
2.L.157.238; 2.L.157.239; 2.L.157.154; 2.L.157.157; 2.L.157.166; 2.L.157.169;
2.L.157.172; 2.L.157.175; 2.L.157.240; 2.L.157.244; 2.L.166.228; 2.L.166.229;
2.L.166.230; 2.L.166.231; 2.L.166.236; 2.L.166.237; 2.L.166.238; 2.L.166.239;
2.L.166.154; 2.L.166.157; 2.L.166.166; 2.L.166.169; 2.L.166.172; 2.L:166.175;
2.L.166.240; 2.L.166.244; 2.L.169.228; 2.L.169.229; 2.L.169.230; 2.L.169.231;
2.L.169.236; 2.L.169.237; 2.L.169.238; 2.L.169.239; 2.L.169.154; 21.169.157;
2.L.169.166; 2.L.169.169; 2.L.169.172; 2.L.169.175; 2.L.169.240; 2.L.169.244;
2.L.172.228; 2.L.172.229; 2.L.172.230; 2.L.172.231; 2.L.172.236; 2.L.172.237;
2.L.172.238; 2.L.172.239; 2.L.172.154; 2.L.172.157; 2.L.172.166; 2.L.172.169;
2.L.172.172; 2.L.172.175; 2.L.172.240; 2.L.172.244; 2.L.175.228; 2.L.175.229;

2.L.175.230; 2.L.175.231; 2.L.175.236; 2.L.175.237; 2.L.175.238; 2.L.175.239;
2.L.175.154; 2.L.175.157; 2.L.175.166; 2.L.175.169; 2.L.175.172; 2.L.175.175;
2.L.175.240; 2.L.175.244; 2.L.240.228; 2.L.240.229; 2.L.240.230; 2.L.240.231;
2.L.240.236; 2.L.240.237; 2.L.240.238; 2.L.240.239; 2.L.240.154; 2.L.240.157;
2.L.240.166; 2.L.240.169; 2.L.240.172; 2.L.240.175; 2.L.240.240; 2.L.240.244;
2.L.244.228; 2.L.244.229; 2.L.244.230; 2.L.244.231; 2.L.244.236; 2.L.244.237;
2.L.244.238; 2.L.244.239; 2.L.244.154; 2.L.244.157; 2.L.244.166; 2.L.244.169;
2.L.244.172; 2.L.244.175; 2.L.244.240; 2.L.244.244;

Prodrugs of 2.0 2Ø228.228; 2Ø228.229; 2Ø228.230; 2Ø228.231; 2Ø228.236; 2Ø228.237;
2Ø228.238; 2Ø228.239; 2Ø228.154; 2Ø228.157; 2Ø228.166; 2Ø228.169;
2Ø228.172; 2Ø228.175; 2Ø228.240; 2Ø228.244; 2Ø229.228; 2Ø229.229;
2Ø229.230; 2Ø229.231; 2Ø229.236; 2Ø229.237; 2Ø229.238; 2Ø229.239;
2Ø229.154; 2Ø229.157; 2Ø229.166; 2Ø229.169; 2Ø229.172; 2Ø229.175;
2Ø229.240; 2Ø229.244; 2Ø230.228; 2Ø230.229; 2Ø230.230; 2Ø230.231;
2Ø230.236; 2Ø230.237; 2Ø230.238; 2Ø230.239; 2Ø230.154; 2Ø230.157;
2Ø230.166; 2Ø230.169; 2Ø230.172; 2Ø230.175; 2Ø230.240; 2Ø230.244;
2Ø231.228; 2Ø231.229; 2Ø231.230; 2Ø231.231; 2Ø231.236; 2Ø231.237;
2Ø231238; 2Ø231.239; 2Ø231.154; 2Ø231.157; 2Ø231.166; 2Ø231.169;
2Ø231.172; 2Ø231.175; 2Ø231.240; 2Ø231.244; 2Ø236.228; 2Ø236.229;
2Ø236.230; 2Ø236.231; 2Ø236.236; 2Ø236.237; 2Ø236.238; 2Ø236.239;
2Ø236.154; 2Ø236.157; 2Ø236.166; 2Ø236.169; 2Ø236.172; 2Ø236.175;
2Ø236.240; 2Ø236.244; 2Ø237.228; 2Ø237.229; 2Ø237.230; 2Ø237.231;
2Ø237.236; 2Ø237.237; 2Ø237.238; 2Ø237.239; 2Ø237.154; 2Ø237.157;
2Ø237.166; 2Ø237.169; 2Ø237.172; 2Ø237.175; 2Ø237.240; 2Ø237.244;
2Ø238.228; 2Ø238.229; 2Ø238.230; 2Ø238.231; 2Ø238.236; 2Ø238.237;
2Ø238.238; 2Ø238.239; 2Ø238.154; 2Ø238.157; 2Ø238.166; 2Ø238.169;
2Ø238.172; 2Ø238.175; 2Ø238.240; 2Ø238.244; 2Ø239.228; 2Ø239.229;
2Ø239.230; 2Ø239.231; 2Ø239.236; 2Ø239.237; 2Ø239.238; 2Ø239.239;
2Ø239.154; 2Ø239.157; 2Ø239.166; 2Ø239.169; 2Ø239.172; 2Ø239.175;

2Ø239.240; 2Ø239.244; 2Ø154.228; 2Ø154.229; 2Ø154.230; 2Ø154.231;
2Ø154.236; 2Ø154.237; 2Ø154.238; 2Ø154.239; 2Ø154.154; 2Ø154.157;
2Ø154.166; 2Ø154.169; 2Ø154.172; 2Ø154.175; 2Ø154.240; 2Ø154.244;
2Ø157.228; 2Ø157.229; 2Ø157.230; 2Ø157.231; 2Ø157.236; 2Ø157.237;
2Ø157.238; 2Ø157.239; 2Ø157.154; 2Ø157.157; 2Ø157.166; 2Ø157.169;
2Ø157.172; 2Ø157.175; 2Ø157.240; 2Ø157.244; 2Ø166.228; 2Ø166.229;
2Ø166.230; 2Ø166.231; 2Ø166.236; 2Ø166.237; 2Ø166.238; 2Ø166.239;
2Ø166.154; 2Ø166.157; 2Ø166.166; 2Ø166.169; 2Ø166.172; 2Ø166.175;
2Ø166.240; 2Ø166.244; 2Ø169.228; 2Ø169.229; 2Ø169.230; 2Ø169.231;
2Ø169.236; 2Ø169.237; 2Ø169.238; 2Ø169.239; 2Ø169.154; 2Ø169.157;
2Ø169.166; 2Ø169.169; 2Ø169.172; 2Ø169.175; 2Ø169.240; 2Ø169.244;
2Ø172.228; 2Ø172.229; 2Ø172.230; 2Ø172.231; 2Ø172.236; 2Ø172.237;
2Ø172.238; 2Ø172.239; 2Ø172.154; 2Ø172.157; 2Ø172.166; 2Ø172.169;
2Ø172.172; 2Ø172.175; 2Ø172.240; 2Ø172.244; 2Ø175.228; 2Ø175.229;
2Ø175.230; 2Ø175.231; 2Ø175.236; 2Ø175.237; 2Ø175.238; 2Ø175.239;
2Ø175.154; 2Ø175.157; 2Ø175.166; 2Ø175.169; 2Ø175.172; 2Ø175.175;
2Ø175.240; 2Ø175.244; 2Ø240.228; 2Ø240.229; 2Ø240.230; 2Ø240.231;
2Ø240.236; 2Ø240.237; 2Ø240.238; 2Ø240.239; 2Ø240.154; 2Ø240.157;
2Ø240.166; 2Ø240.169; 2Ø240.172; 2Ø240.175; 2Ø240.240; 2Ø240.244;
2Ø244.228; 2Ø244.229; 2Ø244.230; 2Ø244.231; 2Ø244.236; 2Ø244.237;
2Ø244.238; 2Ø244.239; 2Ø244.154; 2Ø244.157; 2Ø244.166; 2Ø244.169;
2Ø244.172; 2Ø244.175; 2Ø244.240; 2Ø244.244;

Prodrugs of 2.P
2.P.228.228; 2.P.228.229; 2.P.228.230; 2.P.228.231; 2.P.228.236; 2.P.228.237;
2.P.228.238; 2.P.228.239; 2.P.228.154; 2.P.228.157; 2.P.228.166; 2.P.228.169;
2.P.228.172; 2.P.228.175; 2.P.228.240; 2.P.228.244; 2.P.229_228; 2.P.229.229;
2.P.229.230; 2.P.229.231; 2.P.229.236; 2.P.229.237; 2.P.229.238; 2.P.229.239;
2.P.229.154; 2.P.229.157; 2.P.229.166; 2.P.229.169; 2.P.229.172; 2.P.229.175;
2.P.229.240; 2.P.229.244; 2.P.230.228; 2.P.230.229; 2.P.230.230; 2.P.230.231;
2.P.230.236; 2.P.230.237; 2.P.230.238; 2.P.230.239; 2.P.230.154; 2.P.230.157;

2.P.230.166; 2.P.230.169; 2.P.230.172; 2.P.230.175; 2.P.230.240; 2.P.230.244;
2.P.231.228; 2.P.231.229; 2.P.231.230; 2.P.231.231; 2.P.231.236; 2.P.231.237;
2.P.231.238; 2.P.231.239; 2.P.231.154; 2.P.231.157; 2.P.231.166; 2.P.231.169;
2.P.231.172; 2.P.231.175; 2.P.231.240; 2.P.231.244; 2.P.236.228; 2.P.236.229;
2.P.236.230; 2.P.236.231; 2.P.236.236; 2.P.236.237; 2.P.236.238; 2.P.236.239;
2.P.236.154; 2.P.236.157; 2.P.236.166; 2.P.236.169; 2.P.236.172; 2.P.236.175;
2.P.236.240; 2.P.236.244; 2.P.237.228; 2.P.237.229; 2.P.237.230; 2.P.237.231;
2.P.237.236; 2.P.237.237; 2.P.237.238; 2.P.237.239; 2.P.237.154; 2.P.237.157;
2.P.237.166; 2.P.237.169; 2.P.237.172; 2.P.237.175; 2.P.237.240; 2.P.237.244;
2.P.238.228; 2.P.238.229; 2.P.238.230; 2.P.238.231; 2.P.238.236; 2.P.238.237;
2.P.238.238; 2.P.238.239; 2.P.238.154; 2.P.238.157; 2.P.238.166; 2.P.238.169;
2.P.238.172; 2.P.238.175; 2.P.238.240; 2.P.238.244; 2.P.239.228; 2.P.239.229;
2.P.239.230; 2.P.239.231; 2.P.239.236; 2.P.239.237; 2.P.239.238; 2.P.239.239;
2.P.239.154; 2.P.239.157; 2.P.239.166; 2.P.239.169; 2.P.239.172; 2.P.239.175;
2.P.239.240; 2.P.239.244; 2.P.154.228; 2.P.154.229; 2.P.154.230; 2.P.154.231;
2.P.154.236; 2.P.154.237; 2.P.154.238; 2.P.154.239; 2.P.154.154; 2.P.154.157;
2.P.154.166; 2.P.154.169; 2.P.154.172; 2.P.154.175; 2.P.154.240; 2.P.154.244;
2.P.157.228; 2.P.157.229; 2.P.157.230; 2.P.157.231; 2.P.157.236; 2.P.157.237;
2.P.157.238; 2.P.157.239; 2.P.157.154; 2.P.157.157; 2.P.157.166; 2.P.157.169;
2.P.157.172; 2.P.157.175; 2.P.157.240; 2.P.157.244; 2.P.166.228; 2.P.166.229;
2.P.166.230; 2.P.166.231; 2.P.166.236; 2.P.166.237; 2.P.166.238; 2.P.166.239;
2.P.166.154; 2.P.166.157; 2.P.166.166; 2.P.166.169; 2.P.166.172; 2.P.166.175;
2.P.166.240; 2.P.166.244; 2.P.169.228; 2.P.169.229; 2.P.169.230; 2.P.169.231;
2.P.169.236; 2.P.169.237; 2.P.169.238; 2.P.169.239; 2.P.169.154; 2.P.169.157;
2.P.169.166; 2.P.169.169; 2.P.169.172; 2.P.169.175; 2.P.169.240; 2.P.169.244;
2.P.172.228; 2.P.172.229; 2.P.172.230; 2.P.172.231; 2.P.172.236; 2.P.172.237;
2.P.172.238; 2.P.172.239; 2.P.172.154; 2.P.172.157; 2.P.172.166; 2.P.172.169;
2.P.172.172; 2.P.172.175; 2.P.172.240; 2.P.172.244; 2.P.175.228; 2.P.175.229;
2.P.175.230; 2.P.175.231; 2.P.175.236; 2.P.175.237; 2.P.175.238; 2.P.175.239;
2.P.175.154; 2.P.175.157; 2.P.175.166; 2.P.175.169; 2.P.175.172; 2.P.175.175;
2.P.175.240; 2.P.175.244; 2.P.240.228; 2.P.240.229; 2.P.240.230; 2.P.240.231;

2.P.240.236; 2.P.240.237; 2.P.240.238; 2.P.240.239; 2.P.240.154; 2.P.240.157;
2.P.240.16,6; 2.P.240.169; 2.P.240.172; 2.P.240.175; 2.P.240.240; 2.P.240.244;
2.P.244.228; 2.P.244.229; 2.P.244.230; 2.P.244.231; 2.P.244.236; 2.P.244.237;
2.P.244.238; 2.P.244.239; 2.P.244.154; 2.P.244.157; 2.P.244.166; 2.P.244.169;
2.P.244.172; 2.P.244.175; 2.P.244.240; 2.P.244.244;
Prodrugs of 2.U
2.U.228.228; 2.U.228.229; 2.U.228.230; 2.U.228.231; 2.U.228.236; 2.U.228.237;
2.U.228.238; 2.U.228.239; 2.U.228.154; 2.U.228.157; 2.U.228.166; 2.U.228.169;
2.U.228.172; 2.U.228.175; 2.U.228.240; 2.U.228.244; 2.U.229.228; 2.U.229229;
2.U.229.230; 2.U.229.231; 2.U.229.236; 2.U.229.237; 2.U.229.238; 2.U.229.239;
2.U.229.154; 2.U.229.157; 2.U.229.166; 2.U.229.169; 2.U.229.172; 2.U.229.175;
2.U.229.240; 2.U.229.244; 2.U.230.228; 2.U.230.229; 2.U.230.230; 2.U.230.231;
2.U.230.236; 2.U.230.237; 2.U.230.238; 2.U.230.239; 2.U.230.154; 2.U.230.157;
2.U.230.166; 2.U.230.169; 2.U.230.172; 2.U.230.175; 2.U.230.240; 2.U.230.244;
2.U.231.228; 2.U.231.229; 2.U.231.230; 2.U.231.231; 2.U.231.236; 2.U.231.237;
2.U.231.238; 2.U.231.239; 2.U.231:154; 2.U.231.157; 2.U.231.166; 2.U.231.169;
2.U.231.172; 2.U.231.175; 2.U.231.240; 2.U.231.244; 2.U.236.228; 2.U.236.229;
2.U.236.230; 2.U.236.231; 2.U.236.236; 2.U.236.237; 2.U.236.238; 2.U.236.239;
2.U.236.154; 2.U.236.157; 2.U.236.166; 2.U.236.169; 2.U.236.172; 2.U.236.175;
2.U.236.240; 2.U.236.244; 2.U.237.228; 2.U.237.229; 2.U.237.230; 2.U.237.231;
2.U.237.236; 2.U.237.237; 2.U.237.238; 2.U.237.239; 2.U.237.154; 2.U.237.157;
2.U.237.166; 2.U.237.169; 2.U.237.172; 2.U.237.175; 2.U.237.240; 2.U.237.244;
2.U.238.228; 2.U.238.229; 2.U.238.230; 2.U.238.231; 2.U.238.236; 2.U.238.237;
2.U.238.238; 2.U.238.239; 2.U.238.154; 2.U.238.157; 2.U.238.166; 2.U.238.169;
2.U.238.172; 2.U.238.175; 2.U.238.240; 2.U.238.244; 2.U.239.228; 2.U.239.229;
2.U.239.230; 2.U.239.231; 2.U.239.236; 2.U.239.237; 2.U.239.238; 2.U.239.239;
2.U.239.154; 2.U.239.157; 2.U.239.166; 2.U.239.169; 2.U.239.172; 2.U.239.175;
2.U.239.240; 2.U.239.244; 2.U.154.228; 2.U.154.229; 2.U.154.230; 2.U.154.231;
2.U.154.236; 2.U.154.237; 2.U.154.238; 2.U.154.239; 2.U.154.154; 2.U.154.157;
2.U.154.166; 2.U.154.169; 2.U.154.172; 2.U.154.175; 2.U.154.240; 2.U.154.244;

2.U.157.228; 2.U.157.229; 2.U.157.230; 2.U.157.231; 2.U.157.236; 2.U.157.237;
2.U.157.238; 2.U.157.239; 2.U.157.154; 2.U.157.157; 2.U.157.166; 2.U.157.169;
2.U.157.172; 2.U.157.175; 2.U.157.240; 2.U.157.244; 2.U.166.228; 2.U.166.229;
2.U.166.230; 2.U.166.231; 2.U.166.236; 2.U.166.237; 2.U.166.238; 2.U.166.239;
2.U.166.154; 2.U.166.157; 2.U.166.166; 2.U.166.169; 2.U.166.172; 2.U.166.175;
2.U.166.240; 2.U.166.244; 2.U.169.228; 2.U.169.229; 2.U.169.230; 2.U.169.231;
2.U.169.236; 2.U.169.237; 2.U.169.238; 2.U.169.239; 2.U.169.154; 2.U.169.157;
2.U.169.166; 2.U.169.169; 2.U.169.172; 2.U.169.175; 2.U.169.240; 2.U.169.244;
2.U.172.228; 2.U.172.229; 2.U.172.230; 2.U.172.231; 2.U.172.236; 2.U.172.237;
2.U.172.238; 2.U:172.239; 2.U.172.154; 2.U.172.157; 2.U.172.166; 2.U.172.169;
2.U.172.172; 2.U.172.175; 2.U.172.240; 2.U.172.244; 2.U.175.228; 2.U.175.229;
2.U.175.230; 2.U.175.231; 2.U.175.236; 2.U.175.237; 2.U.175.238; 2.U.175.239;
2.U.175.154; 2.U.175.157; 2.U.175.166; 2.U.175.169; 2.U.175.172; 2.U.175.175;
2.U.175.240; 2.U.175.244; 2.U.240.228; 2.U.240.229; 2.U.240.230; 2.U.240.231;
2.U.240.236; 2.U.240.237; 2.U.240.238; 2.U.240.239; 2.U.240.154; 2.U.240.157;
2.U.240.166; 2.U.240.169; 2.U.240.172; 2.U.240.175; 2.U.240.240; 2.U.240.244;
2.U.244.228; 2.U.244.229; 2.U.244.230; 2.U.244.231; 2.U.244.236; 2.U.244.237;
2.U.244.238; 2.U.244.239; 2.U.244.154; 2.U.244.157; 2.U.244.166; 2.U.244.169;
2.U.244.172; 2.U.244.175; 2.U.244.240; 2.U.244.244;

Prodrugs of 2.W
2.W.228.228; 2.W.228.229; 2.W.228.230; 2.W.228.231; 2.W.228.236; 2.W.228.237;
2.W.228.238; 2.W.228.239; 2.W.228.154; 2.W.228.157; 2.W.228.166; 2.W.228.169;
2.W.228.172; 2.W.228.175; 2.W.228.240; 2.W.228.244; 2.W.229.228; 2.W.229.229;
2.W.229.230; 2.W.229.231; 2.W.229.236; 2.W.229.237; 2.W.229.238; 2.W.229.239;
2.W.229.154; 2.W.229.157; 2.W.229.166; 2.W.229.169; 2.W.229.172; 2.W.229.175;
2.W.229.240; 2.W.229.244; 2.W.230.228; 2.W.230.229; 2.W.230.230; 2.W.230.231;
2.W.230.236; 2.W.230.237; 2.W.230.238; 2.W.230.239; 2.W.230.154; 2.W.230.157;
2.W.230.166; 2.W.230.169; 2.W.230.172; 2.W.230.175; 2.W.230.240; 2.W.230.244;
2.W.231.228; 2.W.231.229; 2.W.231.230; 2.W.231.231; 2.W.231.236; 2.W.231.237;
2.W.231.238; 2.W.231.239; 2.W.231.154; 2.W.231.157; 2.W.231.166; 2.W.231.169;

2.W.231.172; 2.W.231.175; 2.W.231.240; 2.W.231.244; 2.W.236.228; 2.W.236.229;
2.W.236.230; 2.W.236.231; 2.W.236.236; 2.W.236.237; 2.W.236.238; 2.W.236.239;
2.W.236.154; 2.W.236.157; 2.W.236.166; 2.W.236.169; 2.W.236.172; 2.W.236.175;
2.W.236.240; 2.W.236.244; 2.W.237.228; 2.W.237.229; 2.W.237.230; 2.W.237.231;
2.W.237.236; 2.W.237.237; 2.W.237.238; 2.W.237.239; 2.W.237.154; 2.W.237.157;
2.W.237.166; 2.W.237.169; 2.W.237.172; 2.W.237.175; 2.W.237.240; 2.W.237.244;
2.W.238.228; 2.W.238.229; 2.W.238.230; 2.W.238.231; 2.W.238.236; 2.W.238.237;
2.W.238.238; 2.W.238.239; 2.W.238.154; 2.W.238.157; 2.W.238.166; 2.W.238.169;
2.W.238.172; 2.W.238.175; 2.W.238.240; 2.W.238.244; 2.W.239.228; 2.W.239.229;
2.W.239.230; 2.W.239.231; 2.W.239.236; 2.W.239.237; 2.W.239.238; 2.W.239.239;
2.W.239.154; 2.W.239.157; 2.W.239.166; 2.W.239.169; 2.W.239.172; 2.W.239.175;
2.W.239.240; 2.W.239.244; 2.W.154.228; 2.W.154.229; 2.W.154.230; 2.W.154.231;
2.W.154.236; 2.W.154.237; 2.W.154.238; 2.W.154.239; 2.W.154.154; 2.W.154.157;
2.W.154.166; 2.W.154.169; 2.W.154.172; 2.W.154.175; 2.W.154.240; 2.W.154.244;
2.W.157.228; 2.W.157.229; 2.W.157.230; 2.W.157.231; 2.W.157.236; 2.W.157.237;
2.W.157.238; 2.W.157.239; 2.W.157.154; 2.W.157.157; 2.W.157.166; 2.W.157.169;
2.W.157.172; 2.W.157.175; 2.W.157.240; 2.W.157.244; 2.W.166.228; 2.W.166.229;
2.W.166.230; 2.W.166.231; 2.W.166.236; 2.W.166.237; 2.W.166.238; 2.W.166.239;
2.W.166.154; 2.W.166.157; 2.W.166.166; 2.W.166.169; 2.W.166.172; 2.W.166.175;
2.W.166.240; 2.W.166.244; 2.W.169.228; 2.W.169.229; 2.W.169.230; 2.W.169.231;
2.W.169.236; 2.W.169.237; 2.W.169.238; 2.W.169.239; 2.W.169.154; 2.W.169.157;
2.W.169.166; 2.W.169.169; 2.W.169.172; 2.W.169.175; 2.W.169.240; 2.W.169.244;
2.W.172.228; 2.W.172.229; 2.W.172.230; 2.W.172231; 2.W.172.236; 2.W.172.237;
2.W.172.238; 2.W.172.239; 2.W.172.154; 2.W.172.157; 2.W.172.166; 2.W.172.169;
2.W.172.172; 2.W.172.175; 2.W.172.240; 2.W.172.244; 2.W.175.228; 2.W.175.229;
2.W.175.230; 2.W.175.231; 2.W.175.236; 2.W.175.237; 2.W.175.238; 2.W.175.239;
2.W.175.154; 2.W.175.157; 2.W.175.166; 2.W.175.169; 2.W.175.172; 2.W.175.175;
2.W.175.240; 2.W.175.244; 2.W.240.228; 2.W.240.229; 2.W.240.230; 2.W.240.231;
2.W.240.236; 2.W.240.237; 2.W.240.238; 2.W.240.239; 2.W.240.154; 2.W.240.157;
2.W.240.166; 2.W.240.169; 2.W.240.172; 2.W.240.175; 2.W.240.240; 2.W.240.244;

2.W.244.228; 2.W.244.229; 2.W.244.230; 2.W.244.231; 2.W.244.236; 2.W.244.237;

2.W.244.238; 2.W.244.239; 2.W.244.154; 2.W.244.157; 2.W.244.166; 2.W.244.169;
2.W.244.172; 2.W.244.175; 2.W.244.240; 2.W.244.244;

Prodrugs of 2.Y
2.Y.228.228; 2.Y.228.229; 2.Y.228.230; 2.Y.228.231; 2.Y.228.236; 2.Y.228.237;
2.Y.228.238; 2.Y.228.239; 2.Y.228.154; 2.Y.228.157; 2.Y.228.166; 2.Y.228.169;
2.Y.228.172; 2.Y.228.175; 2.Y.228.240; 2.Y.228.244; 2.Y.229.228; 2.Y.229.229;
2:Y.229.230; 2.Y.229.231; 2.Y.229.236; 2.Y.229.237; 2.Y.229.238; 2.Y.229.239;
2.Y.229.154; 2.Y.229.157; 2.Y.229.166; 2.Y.229.169; 2.Y.229.172; 2.Y.229.175;
2.Y.229.240; 2.Y.229.244; 2.Y.230.228; 2.Y.230.229; 2.Y.230.230; 2.Y.230.231;
2.Y.230.236; 2.Y.230.237; '2.Y.230.238; 2.Y.230.239; 2.Y.230.154; 2.Y.230.157;
2.Y.230.166; 2.Y.230.169; 2.Y.230.172; 2.Y.230.175; 2.Y.230.240; 2.Y.230.244;
2.Y.231.228; 2.Y.231.229; 2.Y.231.230; 2.Y.231.231; 2.Y.231.236; 2.Y.231.237;
2.Y.231.238; 2.Y.231.239; 2.Y.231.154; 2.Y.231.157; 2.Y.231.166; 2.Y.231.169;
2.Y.231.172; 2.Y.231.175; 2.Y.231.240; 2.Y.231.244; 2.Y.236.228; 2.Y.236.229;
2.Y.236.230; 2.Y.236.231; 2.Y.236.236; 2.Y.236.237; 2.Y.236.238; 2.Y.236.239;
2.Y.236.154; 2.Y.236.157; 2.Y.236.166; 2.Y.236.169; 2.Y.236.172; 2.Y.236.175;
2.Y.236.240; 2.Y.236.244; 2.Y.237.228; 2.Y.237.229; 2.Y.237.230; 2.Y.237.231;
2.Y.237.236; 2.Y.237.237; 2.Y.237.238; 2.Y.237.239; 2.Y.237.154; 2.Y.237.157;
2.Y.237.166; 2.Y.237.169; 2.Y.237.172; 2.Y.237.175; 2.Y.237.240; 2.Y.237.244;
2.Y.238.228; 2.Y.238.229; 2.Y.238.230; 2.Y.238.231; 2.Y.238.236; 2.Y.238.237;
2.Y.238.238; 2.Y.238.239; 2:Y.238.154; 2.Y.238.157; 2.Y.238.166; 2.Y.238.169;
2.Y.238.172; 2.Y.238.175; 2.Y.238.240; 2.Y.238.244; 2.Y.239.228; 2.Y.239.229;
2.Y.239.230; 2.Y.239.231; 2_Y.239.236; 2.Y.239.237; 2.Y.239.238; 2.Y.239.239;
2.Y.239.154; 2.Y.239.157; 2.Y.239.166; 2.Y.239.169; 2.Y.239.172; 2.Y.239.175;
2.Y.239.240; 2.Y.239.244; 2.Y.154.228; 2.Y.154.229; 2.Y.154.230; 2.Y.154.231;
2.Y.154.236; 2.Y.154.237; 2.Y.154.238; 2.Y.154.239; 2.Y.154.154; 2.Y.154.157;
2.Y.154.166; 2.Y.154.169; 2.Y.154.172; 2.Y.154.175; 2.Y.154.240; 2.Y.154.244;
2.Y.157.228; 2.Y.157.229; 2.Y.157.230; 2.Y.157.231; 2.Y.157.236; 2.Y.157.237;
2.Y.157.238; 2.Y.157.239; 2.Y.157.154; 2.Y.157.157; 2.Y.157.166; 2.Y.157.169;
2.Y.157.172; 2.Y.157.175; 2.Y.157.240; 2.Y.157.244; 2.Y.166.228; 2.Y.166.229;

2.Y.166.230; 2.Y.166.231; 2.Y.166.236; 2.Y.166.237; 2.1.166.238; 2.Y.166.239;
2.Y.166.154; 2.Y.166.157; 2.Y.166.166; 2.Y.166.169; 2.Y.166.172; 2.Y.166.175;
2.Y.166.240; 2.Y.166.244; 2.Y.169.228; 2.Y.169.229; 2.Y.169.230; 2.Y.169.231;
2.Y.169.236; 2.Y.169.237; 2.Y.169.238; 2.Y.169.239; 2.Y.169.154; 2.Y.169.157;
2.Y.169.166; 2.Y.169.169; 2.Y.169.172; 2.Y.169.175; 2.Y.169.240; 2.Y.169.244;
2.Y.172.228; 2.1.172.229; 2.Y.172.230; 2.Y.172.231; 2.Y.172.236; 2.Y.172.237;
2.Y.172.238; 2.Y.172.239; 2.Y.172.154; 2.Y.172.157; 2.Y.172.166; 2.Y.172.169;
2.Y.172.172; 2.Y.172.175; 2.Y.172.240; 2.Y.172.244; 2.Y.175.228; 2.Y.175.229;
2.Y.175.230; 2.Y.175.231; 2.Y.175.236; 2.Y.175.237; 2.Y.175.238; 2.Y.175.239;
2.Y.175.154; 2.Y.175.157; 2.Y.175.166; 2.Y.175.169; 2.Y.175.172; 2.Y.175.175;
2.Y.175.240; 2.Y.175.244; 2.Y.240.228; 2.1.240.229; 2.Y.240.230; 2.Y.240.231;
2.Y.240.236; 2.Y.240.237; 2.Y.240.238; 2.Y.240.239; 2.Y.240.154; 2.Y.240.157;
2.1.240:166; 2.1.240_169; 2.Y.240_172; 2.Y.240.175; 2.Y.240.240; 2.Y.240.244;
2.Y.244.228; 2.Y.244.229; 2.Y.244.230; 2.Y.244.231; 2.Y.244.236; 2.Y.244.237;
2.Y.244.238; 2.Y.244.239; 2.Y.244.154; 2.Y.244.157; 2.Y.244.166; 2.Y.244.169;
2.Y.244.172; 2.Y.244.175; 2.Y.244.240; 2.Y.244.244;

Prodrugs of 3.B
3.B.228.228; 3.B.228.229; 3.B.228.230; 3.B.228.231; 3.B.228.236; 3.B.228.237;
3.B:228.238; 3.B.228.239; 3_B.228.154; 3.B.228.157; 3.B.228.166; 3.B.228.169;
3.B.228.172; 3.B.228.175; 3.B.228.240; 3.B.228.244; 3.B.229.228; 3.B.229.229;
3.B.229.230; 3.B.229.231; 3.B.229.236; 3.B.229.237; 3.B.229.238; 3.B.229.239;
3.B.229.154; 3.B.229.157; 3.B.229.166; 3.B.229.169; 3.B.229.172; 3.B.229.175;
3.B.229.240; 3.B.229.244; 3.B.230.228; 3.B.230.229; 3.B.230.230; 3.B.230.231;
3.B.230.236; 3.B.230.237; 3.B.230.238; 3.B.230.239; 3_B.230.154; 3.B.230.157;
3.B.230.166; 3.B.230.169; 3.B.230.172; 3.B.230.175; 3.B.230.240; 3.B.230.244;
3.B.231.228; 3.B.231.229; 3.B.231.230; 3.B.231.231; 3.B.231.236; 3.B.231.237;
3.B.231.238; 3.B.231.239; 3.B.231.154; 3.B.231.157; 3.B.231.166; 3.B.231.169;
3.B.231.172; 3.B.231.175; 3.B.231.240; 3.B.231.244; 3.B.236.228; 3.B.236.229;
3.B.236.230; 3.B.236.231; 3.B.236.236; 3.B.236.237; 3.B.236.238; 3.B.236.239;
3.B.236.154; 3.B.236.157; 3.B.236.166; 3.B.236.169; 3.B.236.172; 3.B.236.175;

3.B.236.240; 3.B.236.244; 3.B.237.228; 3.B.237.229; 3.B.237.230; 3.B.237.231;
3.B.237.236; 3.B.237.237; 3.B.237.238; 3.B.237.239; 3.B.237.154; 3.B.237.157;
3.B.237.166; 3.B.237.169; 3.B.237.172; 3.B.237.175; 3.B.237.240; 3.B.237.244;
3.B.238.228; 3.B_238.229; 3.B.238_230; 3.B.238.231; 3.B.238.236; 3.B.238.237;
3.B.238.238; 3.B.238.239; 3.B.238.154; 3.B.238.157; 3.B.238.166; 3.B.238.169;
3.B.238.172; 3.B.238.175; 3.B.238.240; 3.B.238.244; 3.B.239.228; 3.B.239.229;
3.B.239.230; 3.B.239.231; 3.B.239.236; 3.B.239.237; 3.B.239.238; 3.B.239.239;
3.B.239.154; 3.B.239.157; 3.B.239.166; 3.B.239.169; 3.B.239.172; 3.B.239.175;
3.B.239.240; 3.B.239.244; 3.B.154.228; 3.B.154.229; 3.B.154.230; 3.B.154.231;
3.B.154.236; 3.B.154.237; 3.B.154.238; 3.B.154.239; 3.B.154.154; 3.B.154.157;
3.B.154.166; 3.B.154.169; 3.B.154.172; 3.B_154.175; 3.B.154.240; 3.B.154.244;
3.B.157.228; 3.B.157.229; 3.B.157.230; 3.B.157.231; 3.B.157.236; 3.B.157.237;
3.B.157.238; 3.B.157.239; 3.B.157.154; 3.B.157.157; 3.B.157.166; 3.B.157.169;
3.B.157.172; 3.B.157.175; 3.B.157.240; 3.B.157.244; 3.B.166.228; 3.B.166.229;
3.B.166.230; 3.B.166.231; 3.B.166.236; 3.B.166.237; 3.B.166.238; 3.B.166.239;
3.B.166.154; 3.B.166.157; 3.B.166.166; 3.B.166.169; 3.B.166.172; 3.B.166.175;
3.B.166.240; 3.B.166.244; 3.B.169.228; 3.B.169.229; 3.B.169.230; 3.B.169.231;
3.B.169.236; 3.B.169.237; 3.B.169.238; 3.B.169.239; 3.B.169.154; 3.B.169.157;
.3.B.169.166; 3.B.169.169; 3.B.169.172; 3.B.169.175; 3.B.169.240; 3.B.169.244;
3.B.172.228; 3.B.172:229; 3.B.172.230; 3.B.172.231; 3.B.172.236; 3.13.172237;
3.B.172.238; 3.B.172.239; 3.B.172.154; 3.B.172.157; 3.B.172.166; 3.B.172.169;
3.B.172.172; 3.B.172.175; 3.B.172.240; 3.B.172.244; 3.B.175.228; 3.B.175.229;
3.B.175.230; 3.B.175.231; 3.B.175.236; 3.B.175.237; 3.B.175.238; 3.B.175.239;
3.B.175.154; 3.B.175.157; 3.B.175.166; 3.B.175.169; 3.B.175.172; 3.B.175.175;
3.B.175.240; 3.B.175.244; 3.B.240.228; 3.B.240.229; 3.B.240.230; 3.B.240.231;
3.B.240.236; 3.B.240.237; 3.B.240.238; 3.B.240.239; 3.B.240.154; 3.B.240.157;
3.B.240.166; 3.B.240.169; 3.B.240.172; 3.B.240.175; 3.B.240.240; 3.B.240.244;
3.B.244.228; 3.B.244.229; 3.B.244.230; 3.B.244.231; 3.B.244_236; 3.B.244.237;
3.B.244.238; 3.B.244.239; 3.B.244.154; 3.B.244.157; 3.B.244_166; 3.B.244.169;
3.B.244.172; 3.B.244.175; 3.B.244.240; 3.B.244.244;

Prodrugs of 3.D
3.D.228.228; 3.D.228.229; 311228.230; 3.D.228.231; 3.D.228.236; 3.D.228.237;
3.D.228.238; 3.D.228.239; 3.D.228.154; 3.D.228.157; 3.D.228.166; 3.D.228.169;
3.D.228.172; 3.D.228.175; 3.D.228.240; 3.D.228.244; 3.D.229.228; 3.D.229.229;
3.D.229.230; 3.D.229.231; 3.D.229.236; 3.D.229.237; 3.D.229.238; 3.D.229.239;
3.D.229.154; 3.D.229.157; 3.D.229.166; 3.D.229.169; 3.D.229.172; 3.D.229.175;
3.D.229.240; 3.D.229.244; 3.D.230.228; 3.D.230.229; 3.D.230.230; 3.D.230.231;
3.D.230.236; 3.D.230.237; 3.D.230.238; 3.D.230.239; 3.D.230.154; 3.D.230.157;
3.D.230.166; 3.D.230.169; 3.D.230.172; 3.D.230.175; 3.D.230.240; 3.D.230.244;
3.D.231.228; 3.D.231.229; 3.D.231.230; 3.D.231.231; 3.D.231.236; 3.D.231.237;
3.D.231.238; 3.D.231.239; 3.D.231.154; 3.D.231.157; 3.D.231.166; 3.D.231.169;
3.D.231.172; 3.D.231.175; 3.D.231.240; 3.D.231.244; 3.D.236.228; 3.D.236.229;
3.D.236.230; 3.D.236.231; 3.D.236.236; 3.D.236.237; 3.D.236.238; 3.D.236.239;
3.D.236.154; 3.D.236.157; 3.D.236.166; 3.D.236.169; 3.D.236.172; 3.D.236.175;
3.D.236.240; 3.D.236.244; 3.D.237.228; 3.D.237.229; 3.D.237.230; 3.D.237.231;
3.D.237.236; 3.D.237.237; 3.D.237.238; 3.D.237.239; 3.D.237.154; 3.D.237.157;
3.D.237.166; 3.D.237.169; 3.D.237.172; 3.D.237.175; 3.D.237.240; 3.D.237.244;
3.D.238.228; 3.D.238.229; 3.D.238.230; 3.D.238.231; 3.D.238.236; 3.D.238.237;
3.D.238.238; 3.D.238.239; 3.D.238.154; 3.D.238.157; 3.D.238.166; 3.D.238.169;
3.D.238.172; 3.D.238.175; 3.D.238.240; 3.D.238.244; 3.D.239.228; 3.D.239.229;
3.D.239.230; 3.D.239.231; 3.D.239.236; 3.D.239.237; 3.D.239.238; 3.D.239.239;
3.D.239.154; 3.D.239.157; 3.D.239.166; 3.D.239.169; 3.D.239.172; 3.D.239.175;
3.D.239.240; 3.D.239.244; 3.D.154.228; 3.D.154.229; 3.D.154.230; 3.D.154.231;
3.D.154.236; 3.D.154.237; 3.D.154.238; 3.D.154.239; 3.D.154.154; 3.D.154.157;
3.D.154.166; 3.D.154.169; 3.D.154.172; 3.D.154.175; 3.D.154.240; 3.D.154.244;
3.D.157.228; 3.D.157.229; 3.D.157.230; 3.D.157.231; 3.D.157.236; 3.D.157.237;
3.D.157.238; 3.D.157.239; 3.D.157.154; 3.D.157.157; 3.D.157.166; 3.D.157.169;
3.D.157.172; 3.D.157.175; 3.D.157.240; 3.D.157.244; 3.D.166.228; 3.D.166.229;
3.D.166.230; 3.D.166.231; 3.D.166.236; 3.D.166.237; 3.D.166.238; 3.D.166.239;
3.D.166.154; 3.D.166.157; 3.D.166.166; 3.D.166.169; 3.D.166.172; 3.D.166.175;
3.D.166.240; 3.D.166.244; 3.D.169.228; 3.D.169.229; 3.D.169.230; 3.D.169.231;

3.D.169.236; 3.D.169.237; 3Ø169.238; 3.D.169.239; 3Ø169.154; 3.D.169.157;
3.D.169.166; 3.D.169.169; 3.D.169.172; 3.D.169.175; 3.D.169.240; 3.D.169.244;
3.D.172.228; 3.D.172.229; 3.D.172.230; 3.D.172.231; 3.D.172.236; 3.D.172.237;
3.D.172.238; 3.D.172.239; 3.D.172.154; 3.D.172.157; 3Ø172.166; 3.D.172.169;
3.D.172.172; 3.D.172.175; 3.D.172.240; 3.D.172.244; 3Ø175.228; 3.D.175.229;
3.D.175.230; 3.D.175.231; 3.D.175.236; 3.D.175.237;'3.D.175.238; 3.D.175.239;
3Ø175.154; 3.D.175.157; 3.D.175.166; 3.D.175.169; 3.D.175.172; 3.D.175.175;
3.D.175.240; 3.D.175.244; 3.D.240.228; 3.D.240.229; 3.D.240.230; 3.D.240.231;
3Ø240.236; 3.D.240.237; 3.D.240.238; 3Ø240.239; 3.D.240.154; 3.D.240.157;
3.D.240.166; 3Ø240.169; 3.D.240.172; 3.D.240.175; 3.D.240.240; 3.D.240.244;
3.D.244.228; 3.D.244.229; 3.D.244.230; 3.D.244.231; 3.D.244.236; 3.D.244.237;
3.D.244.238; 3.D.244.239; 3.D.244.154; 3Ø244.157; 3Ø244_166; 3.D.244.169;
3.D.244.172; 3.D.244.175; 3.D.244.240; 3.D.244.244;

Prodrugs of 3.E
3.E.228.228; 3.E.228.229; 3.E.228.230; 3.E.228.231; 3.E.228.236; 3.E.228.237;
3.E.228.238; 3.E.228.239; 3.E.228.154; 3.E.228.157; 3.E.228.166; 3.E.228.169;
3.E.228.172; 3.E.228.175; 3.E.228.240; 3.E.228.244; 3.E.229.228; 3.E.229.229;
3.E.229.230; 3.E.229.231; 3.E.229.236; 3.E.229.237; 3.E.229.238; 3.E.229.239;
3.E.229.154; 3.E.229.157; 3.E.229.166; 3.E.229.169; 3.E.229.172; 3.E.229.175;
3.E.229.240; 3.E.229.244; 3.E.230.228; 3.E.230.229; 3.E.230.230; 3.E.230.231;
3.E.230.236; 3.E.230.237; 3.E.230.238; 3.E.230.239; 3.E.230.154; 3.E.230.157;
3.E.230.166; 3.E.230.169;'3.E.230.172; 3.E.230.175; 3.E.230.240; 3.E.230.244;
3.E.231.228; 3.E.231.229; 3.E.231.230; 3.E.231.231; 3.E.231.236; 3.E.231.237;
3.E.231.238; 3.E.231.239; 3.E.231.154; 3.E.231.157; 3.E.231.166; 3.E.231.169;
3.E.231.172; 3.E.231.175; 3.E.231.240; 3.E.231.244; 3.E.236.228; 3.E.236.229;
3.E.236.230; 3.E.236.231; 3.E.236.236; 3.E.236.237; 3.E.236.238; 3.E.236.239;
3.E.236.154; 3.E.236.157; 3.E.236.166; 3.E.236.169; 3.E.236.172; 3.E.236.175;
3.E.236.240; 3.E.236.244; 3.E.237.228; 3.E.237.229; 3.E.237.230; 3.E.237.231;
3.E.237.236; 3.E.237.237; 3.E.237.238; 3.E.237.239; 3.E.237.154; 3.E.237.157;
3.E.237.166; 3.E.237.169; 3.E.237.172; 3.E.237.175; 3.E.237.240; 3.E.237.244;

3.E.238.228; 3.E.238.229; 3.E.238.230; 3.E.238.231; 3.E.238.236; 3.E.238.237;
3.E.238.238; 3.E.238.239; 3.E.238.154; 3.E.238.157; 3.E.238.166; 3.E.238.169;
3.E.238.172; 3.E.238.175; 3.E.238.240; 3.E.238.244; 3.E.239.228; 3.E.239.229;
3.E.239.230; 3.E.239.231; 3.E.239.236; 3.E.239.237; 3.E.239.238; 3.E.239.239;
3.E.239.154; 3.E.239.157; 3.E.239.166; 3.E.239.169; 3.E.239.172; 3.E.239.175;
3.E.239.240; 3.E.239.244; 3.E.154.228; 3.E.154.229; 3.E.154.230; 3.E.154.231;
3.E.154.236; 3.E.154.237; 3.E.154.238; 3.E.154.239; 3.E.154.154; 3.E.154.157;
3.E.154.166; 3.E.154.169; 3.E.154.172; 3.E.154.175; 3.E.154.240; 3.E.154.244;
3.E.157.228; 3.E.157.229; 3.E.157.230; 3.E.157.231; 3.E_157.236; 3.E.157.237;
3.E.157.238; 3.E.157.239; 3.E.157.154; 3.E.157.157; 3.E.157.166; 3.E.157.169;
3.E.157.172; 3.E.157.175; 3.E.157.240; 3.E.157.244; 3.E.166.228; 3.E.166.229;
3.E.166.230; 3.E.166.231; 3.E.166.236; 3.E.166.237; 3.E.166.238; 3.E.166.239;
3.E.166.154; 3.E.166.157; 3.E.166.166; 3.E.166.169; 3.E.166.172; 3.E.166.175;
3.E.166.240; 3.E.166.244; 3.E.169.228; 3.E.169.229; 3.E.169.230; 3.E.169.231;
3.E.169.236; 3.E.169.237; 3.E_169.238; 3.E.169.239; 3.E.169.154; 3.E.169.157;
3.E.169.166; 3.E.169.169; 3.E.169.172; 3.E.169.175; 3.E.169.240; 3.E.169.244;
3.E.172.228; 3.E.172.229; 3.E.172.230; 3.E.172.231; 3.E.172.236; 3.E.172.237;
3.E.172.238; 3.E.172.239; 3.E.172.154; 3.E.172.157; 3.E.172.166; 3.E.172.169;
3.E.172.172; 3.E.172.175; 3.E.172.240; 3.E.172.244; 3.E.175.228; 3.E.175.229;
3.E.175.230; 3.E.175.231; 3.E.175.236; 3.E.175.237; 3.E.175.238; 3.E.175.239;
3.E.175.154; 3.E.175.157; 3.E.175.166; 3.E.175.169; 3.E.175.172; 3.E.175.175;
3.E.175.240; 3.E.175.244; 3.E.240.228; 3.E.240.229; 3.E.240.230; 3.E.240.231;
3.E.240.236; 3.E.240.237; 3.E.240.238; 3.E.240.239; 3.E.240.154; 3.E.240.157;
3.E.240.166; 3.E.240.169; 3.E.240.172; 3.E.240.175; 3.E.240.240; 3.E.240.244;
3.E.244.228; 3.E.244.229; 3.E.244.230; 3.E.244.231; 3.E.244.236; 3.E.244.237;
3.E.244.238; 3.E.244.239; 3.E.244.154; 3.E.244.157; 3.E.244.166; 3.E.244.169;
3.E.244.172; 3.E.244.175; 3.E.244.240; 3.E.244.244;

Prodrugs of 3.G
3.G.228.228; 3.G.228.229; 3.G228.230; 3.G.228.231; 3.G.228.236; 3.G.228.237;
3.G.228.238; 3.G.228.239; 3.G.228.154; 3.G.228.157; 3.G.228.166; 3.G.228.169;

3.G.228.172; 3.G.228.175; 3.G.228.240; 3.G.228.244; 3.G.229.228; 3.G.229.229;
3.G.229.230; 3.G.229.231; 3.G.229.236; 3.G.229.237; 3.G.229.238; 3.G.229.239;
3.G.229.154; 3.G.229.157; 3.G.229.166; 3.G.229.169; 3.G.229.172; 3.G.229.175;
3.G.229.240; 3.G.229.244; 3.G.230.228; 3.G.230.229; 3.G.230.230; 3.G.230.231;
3.G.230.236; 3.G.230.237; 3.G.230.238; 3.G.230.239; 3.G.230.154; 3.G.230.157;
.10 3.G.230.166; 3.G.230.169; 3.G.230.172; 3.G.230.175; 3.G.230.240;
3.G.230.244;
3.G.231.228; 3.G.231.229; 3.G.231.230; 3.G.231.231; 3.G.231.236; 3.G.231.237;
3.G.231.238; 3.G.231.239; 3.G.231.154; 3.G.231.157; 3.G:231.166; 3.G.231.169;
3.G.231.172; 3.G.231.175; 3.G.231.240; 3.G.231.244; 3.G.236.228; 3.G.236.229;
3.G.236.230; 3.G.236.231; 3.G.236.236; 3.G.236.237; 3.G.236.238; 3.G.236.239;
3.G.236.154; 3.G.236.157; 3.G.236.166; 3.G.236.169; 3.G.236.172; 3.G.236.175;
3.G.236.240; 3.G.236.244; 3.G.237.228; 3.G.237.229; 3.G.237.230; 3.G.237.231;
3.G.237.236; 3.G.237.237; 3.G.237.238; 3.G.237.239; 3.G.237.154; 3.G.237.157;
3.G.237.166; 3.G.237.169; 3.G.237.172; 3.G.237.175; 3.G.237.240; 3.G.237.244;
3.G.238.228; 3.G.238.229; 3.G.238.230; 3.G.238.231; 3.G.238.236; 3.G.238.237;
3.G.238.238; 3.G.238.239; 3.G.238.154; 3.G.238.157; 3.G.238.166; 3.G.238.169;
3.G.238.172; 3.G.238.175; 3.G.238.240; 3.G.238.244; 3.G.239.228; 3.G.239.229;
3.G.239.230; 3.G.239.231; 3.G.239.236; 3.G.239.237; 3.G.239.238; 3.G.239.239;
3.G.239.154; 3.G.239.157; 3.G.239.166; 3.G.239.169; 3.G.239.172; 3.G.239.175;
3.G.239.240; 3.G.239.244; 3.G.154.228; 3.G.154.229; 3.G.154.230; 3.G.154.231;
3.G.154.236; 3.G.154.237; 3.G.154.238; 3.G.154.239; 3.G.154.154; 3.G.154.157;
3.G.154.166; 3.G.154.169; 3.G.154.172; 3.G.154.175; 3.G.154.240; 3.G.154.244;
3.G.157.228; 3.G.157.229; 3.G.157.230; 3.G.157.231; 3.G.157.236; 3.G.157.237;
3.G.157.238; 3.G.157.239; 3.G.157.154; 3.G.157.157; 3.G.157.166; 3.G.157.169;
3.G.157.172; 3.G.157.175; 3.G.157.240; 3.G.157.244; 3.G.166.228; 3.G.166.229;
3.G.166.230; 3.G.166.231; 3.G.166.236; 3.G.166.237; 3.G.166.238; 3.G.166.239;
3.G.166.154; 3.G.166.157; 3.G.166.166; 3.G.166.169; 3.G.166.172; 3.G.166.175;
3.G.166.240; 3.G.166.244; 3.G.169.228; 3.G.169.229; 3.G.169.230; 3.G.169.231;
3.G.169.236; 3.G.169.237; 3.G.169.238; 3.G.169.239; 3.G.169.154; 3.G.169.157;
3.G.169.166; 3.G.169.169; 3.G.169.172; 3.G.169.175; 3.G.169.240; 3.G.169.244;
3.G.172.228; 3.G.172.229; 3.G.172.230; 3.G.172.231; 3.G.172.236; 3.G.172.237;

3.G.172.238; 3.G.172.239; 3.G.172.154; 3.G.172.157; 3.G.172.166; 3.G.172.169;
3.G.172.172; 3.G.172.175; 3.G.172.240; 3.G.172.244; 3.G.175.228; 3.G.175.229;
3.G.175.230; 3.G.175.231; 3.G.175.236; 3.G.175.237; 3.G.175.238; 3.G.175.239;
3.G.175.154; 3.G.175.157; 3.G.175.166; 3.G.175.169; 3.G.175.172; 3.G.175.175;
3.G.175.240; 3.G.175.244; 3.G.240.228; 3.G.240.229; 3.G.240.230; 3.G.240.231;
3.G.240.236; 3.G.240.237; 3.G.240.238; 3.G.240.239; 3.G.240.154; 3.G.240.157;
3.G.240.166; 3.G.240.169; 3.G.240.172; 3.G.240.175; 3.G.240.240; 3.G.240.244;
3.G.244.228; 3.G.244.229; 3.G.244.230; 3.G.244.231; 3.G.244.236; 3.G.244.237;
3.G.244.238; 3.G.244.239; 3.G.244.154; 3.G.244.157; 3.G.244.166; 3.G.244.169;
3.G.244.172; 3.G.244.175; 3.G.244.240; 3.G.244.244;
Prodrugs of 31 3.1.228.228; 3.1.228.229; 3.1.228.230; 3.1.228.231; 3.1.228.236; 3.1.228.237;
3.1.228.238; 3.1.228.239; 3.1.228.154; 3.1.228.157; 3.1.228.166; 3.1.228.169;
3.1.228.172;
3.1.228.175; 3.1.228.240; 3.1.228.244; 3.1.229.228; 3.1.229.229; 3.1.229.230;
3.1.229.231;
3.1.229.236; 3.1.229.237; 3.1.229.238; 3.1.229.239; 3.1.229.154; 3.1.229.157;
3.1.229.166;
3.1.229.169; 3.1.229.172; 3.1.229.175; 3.1.229.240; 3.1.229.244; 31.230.228;
3.1.230.229;
3.1.230.230; 3.1.230.231; 3.1.230.236; 3.1.230.237; 3.1.230.238; 3.1.230.239;
3.1.230.154;
3.1.230.157; 3.1.230.166; 3.1.230.169; 3.1.230.172; 3.1.230.175; 3.1.230.240;
3.1.230.244;
3.1.231.228; 3.1.231.229; 3.1.231.230; 3.1.231.231; 3.1.231.236; 3.1.231.237;
3.1.231.238;
3.1.231.239; 3.1.231.154; 3.1.231.157; 3.1.231.166; 3.1.231.169; 31.231.172;
3.1.231.175;
3.1.231.240; 3.1.231.244; 3.1.236.228; 3.1.236.229; 3.1.236.230; 3.1.236.231;
3.1.236.236;
3.1.236.237; 3.1.236.238; 3.1.236.239; 3.1.236.154; 3.1.236.157; 3.1.236.166;
3.1.236.169;
3.1.236.172; 3.1.236.175; 3.1.236.240; 3.1.236.244; 3.1.237.228; 3.1.237.229;
3.1.237.230;
3.1.237.231; 3.1.237.236; 3.1.237.237; 3.1.237.238; 3.1.237.239; 3.1.237.154;
3.1.237.157;
3.1.237.166; 3.1.237.169; 3.1.237.172; 3.1.237.175; 3.1.237.240; 3.1.237.244;
3.1.238.228;
3.1.238.229; 3.1.238.230; 3.1.238.231; 3.1.238.236; 3.1.238.237; 3.1.238.238;
3.1.238.239;
3.1.238.154; 3.1.238.157; 3.1.238.166; 3.1.238.169; 3.1.238.172; 3.1.238.175;
3.1.238.240;
3.1.238.244; 3.1.239.228; 3.1.239.229; 3.1.239.230; 3.1.239.231; 3.1.239.236;
3.1.239.237;
3.1.239.238; 3.1.239.239; 3.1.239.154; 3.1.239.157; 3.1.239.166; 3.1.239.169;
3.1.239.172;
3.1.239.175; 3.1.239.240; 3.1.239.244; 3.1.154.228; 3.1.154.229; 3.1.154.230;
3.1.154.231;

3.1.154.236; 3.1.154.237; 3.1.154.238; 3.1.154.239; 3.1.154.154; 3.1.154.157;
3.1.154.166;
3.1.154.169; 3.1.154.172; 3.1.154.175; 3.1.154.240; 3.1.154.244; 3.1.157.228;
3.1.157.229;
3.1.157.230; 3.1.157.231; 3.1.157.236; 3.1.157.237; 3.1.157.238; 3.1.157.239;
3.1.157.154;
3.1.157.157; 3.1.157.166; 3.1.157.169; 3.1.157.172; 3.1.157.175; 3.1.157.240;
3.1.157.244;
3.1.166.228; 3.1.166.229; 3.1.166.230; 3.1.166.231; 3.1.166.236; 3.1.166.237;
3.1.166.238;
3.1.166.239; 3,1.166.154; 3.1.166.157; 3.1.166.166; 3.1.166.169; 3.1.166.172;
3.1.166.175;
- 3.1.166.240; 3.1.166.244; 31169.228; 3.1.169.229; 3.1.169.230; 3.1.169.231;
3.1.169.236;
3.1.169.237; 3.1.169.238; 3.1.169.239; 3.1.169.154; 3.1.169.157; 3.1.169.166;
3.1.169.169;
3.1.169.172; 3.1.169.175; 3.1.169.240; 3.1.169.244; 31172.228; 3.1.172.229;
3.1.172.230;
3.1.172.231; 3.1.172.236; 3.1.172.237; 3.1.172.238; 3.1.172.239; 3.1.172.154;
3.1.172.157;
3.1.172.166; 3.1.172.169; 3.1.172.172; 3.1.172.175; 3.1.172.240; 3.1.172.244;
3.1.175.228;
31175.229; 3.1.175.230; 3.1.175.231; 3.1.175.236; 3.1.175.237; 3.1.175.238;
3.1.175.239;
3.1.175.154; 3.1.175.157; 3.1.175.166; 3.1.175.169; 3.1.175.172; 3.1.175.175;
3.1.175.240;
3.1.175.244; 3.1.240.228; 3.1.240.229; 3.1.240.230; 3.1.240.231; 3.1.240.236;
3.1.240.237;
3.1.240.238; 3.1.240.239; 3.1.240.154; 3.1.240.157; 3.1.240.166; 3.1.240.169;
3.1.240.172;
3.1.240.175; 3.1.240.240; 3.1.240.244; 3.1.244.228; 3.1.244.229; 3.1.244.230;
3.1.244.231;
3.1.244.236; 3.1.244.237; 3.1.244.238; 3.1.244.239; 3.1.244.154; 3.1.244.157;
3.1.244.166;
3.1.244.169; 3.1.244.172; 3.1.244.175; 3.1.244.240; 3.1.244.244;

Prodru s~ of 3.1 3.J.228.228; 3.J.228.229; 3.J.228.230; 3.J.228.231; 3.J.228.236; 3.J.228.237;
3.J.228.238; 3.J.228.239; 3.J.228.154; 3.J.228.157; 3.J.228.166; 3.J.228.169;
3.J.228.172;
3.J.228.175; 3.J.228.240; 3.J.228.244; 3.J.229.228; 3.J.229.229; 3.J.229.230;
3.J.229.231;
3.J.229.236; 3.J.229.237; 3.J.229.238; 3.J.229.239; 3.J.229.154; 3.J.229.157;
3.J.229.166;
3.J.229.169; 3.J.229.172; 3.J.229.175; 3.J.229.240; 3.J.229.244; 3.J.230.228;
3.J.230.229;
3.J.230.230; 3.J.230.231; 3.J.230.236; 3.J.230.237; 3.J.230.238; 3.J.230.239;
3.J.230.154;
3.J.230.157; 3.J.230.166; 3.J.230.169; 3.J.230.172; 3.J.230_175; 3.J.230.240;
3.J.230.244;
3.J.231.228; 3.J.231.229; 3.1.231.230; 3.J.231.231; 3.J.231.236; 3.J.231.237;
3.J.231.238;
3.J.231.239; 3.J.231.154; 3.J.231.157; 3.J.231.166; 3.J.231.169; 3.J.231.172;
3.J.231.175;
3.J.231.240; 3.J.231.244; 3.J.236.228; 3.J.236.229; 3.J.236.230; 3.J.236.231;
3.J.236.236;
3.J.236.237; 3.J.236.238; 3.J.236.239; 3.J.236.154; 3.J.236.157; 3.J.236.166;
3.J.236.169;

3.J.236.172; 3.J.236.175; 3.J.236.240; 3.J.236.244; 3.J.237.228; 3.J.237.229;
3.J.237.230;
3.J.237.231; 3.J.237.236; 3.J.237.237; 3.J.237.238; 3.J.237.239; 3.J.237.154;
3.J.237.157;
3.J.237.166; 3.J.237.169; 3.J.237.172; 3.J.237.175; 3.J.237.240; 3.J.237.244;
3.J.238.228;
3.J.238.229; 3.J.238.230; 3.J.238.231; 3.J.238.236; 3.J.238.237; 3.J.238.238;
3.J.238.239;
3.J.238.154; 3.J.238.157; 3.J.238.166; 3.J.238.169; 3.J.238.172;
3.J.238.175;'3:J.238.240;
3.J.238.244; 3.J.239.228;.3.J.239.229; 3.J.239.230; 3.J.239.231; 3.J.239.236;
3.J.239.237;
3.J.239.238; 3.J.239.239; 3.J.239.154; 3.J.239.157; 3.J.239.166; 3.J.239.169;
3.J.239.172;
3.J.239.175; 3.J.239.240; 3.J.239.244; 3.J.154.228; 3.J.154.229; 3.J.154.230;
3.J.154.231;
3.J.154.236; 3.J.154.237; 3.J.154.238; 3.J.154.239; 3.J.154.154; 3.J.154.157;
3.J.154.166;
3.J.154.169; 3.J.154.172; 3.J.154.175; 3.J.154.240; 3.J.154.244; 3.J.157.228;
3.J.157.229;
3.J.157.230; 3.J.157.231; 3.J.157.236; 3.J.157.237; 3.J.157.238; 3.J.157.239;
3.J.157.154;
3.J.157.157; 3.J.157.166; 3.J.157.169; 3.J.157.172; 3.J.157.175; 3.J.157.240;
3.J.157.244;
3.J.166.228; 3.J.166.229; 3.J.166.230; 3.J.166.231; 3.J.166.236; 3.J.166.237;
3.J.166.238;
3.J.166.239;.3.J.166.154; 3.J.166.157; 3.J.166.166; 3.J.166.169; 3.J.166.172;
3.J.166.175;
3.J.166.240; 3.J.166.244; 3.J.169.228; 3.J.169.229; 3.J.169.230; 3.J.169.231;
3.J.169.236;
3.J.169.237; 3.J.169.238; 3.J.169.239; 3.J.169.154; 3.J.169.157; 3.J.169.166;
3.J.169.169;
3.J.169.172; 3.J.169.175; 3.J.169.240; 3.J.169.244; 3.J.172.228; 3.J.172.229;
3.J.172.230;
3.J.172.231; 3.J.172.236; 3.J.172.237; 3.J.172.238; 3.J.172.239; 3.J.172.154;
3.J.172.157;
3.J.172.166; 3.J.172.169; 3.J.172.172; 3.J.172.175; 3.J.172.240; 3.J.172.244;
3.J.175.228;
3.J.175.229; 3.J.175.230; 3.J.175.231; 3.J.175.236; 3.J.175.237; 3.J.175.238;
3.J.175.239;
3.J.175.154; 3.J.175.157; 3.J.175.166; 3.J.175.169; 3.J.175.172; 3.J.175.175;
3.J.175.240;
3.J.175.244; 3.J.240.228; 3.J.240_229; 3.J.240.230; 3.J.240.231; 3.J.240.236;
3.J.240.237;
3.J.240.238; 3.J.240.239; 3.J.240.154; 3.J.240.157; 3.J.240.166; 3.J.240.169;
3.J.240.172;
3.J.240.175; 3.J.240.240; 3.J.240.244; 3.J.244.228; 3.J.244.229; 3.J.244.230;
3.J.244.231;
3.J.244.236; 3.J.244.237; 3.J.244.238; 3.J.244.239; 3.J.244.154; 3.J.244.157;
3.J.244.166;
3.J.244.169; 3.J.244.172; 3.J.244.175; 3.J.244.240; 3.J.244.244;

Prodrugs of 3.L
3.L.228.228; 3.L.228.229; 3.L.228.230; 3.L.228.231; 3.L.228.236; 3.L.228.237;
3.L.228.238; 3.L.228.239; 3.L.228.154; 3.L.228.157; 3.L.228.166; 3.L.228.169;
3.L.228.172; 3.L.228.175; 3.L.228.240; 3.L.228.244; 3.L.229.228; 3.L.229.229;

3.L.229.230; 3.L.229.231; 3.L.229.236; 3.L.229.237; 3.L.229.238; 3.L.229.239;
3.L.229.154; 3.L.229.157; 3.L.229.166; 3.L.229.169; 3.L.229.172; 3.L.229.175;
3.L.229.240; 3.L.229.244; 3.L.230.228; 3.L.230.229; 3.L.230.230; 3.L.230.231;
3.L.230.236; 3.L.230.237; 3.L.230.238; 3.L.230.239; 3.L.230.154; 3.L.230.157;
3.L.230.166; 3.L.230.169; 3.L.230.172; 3.L.230.175; 3.L.230.240; 3.L.230.244;
3.L.231.228; 3.L.231.229; 3.L.231.230; 3.L.231.231; 3.L.231.236; 3.L.231.237;
3.L.231.238; 3.L.231.239; 3.L.231.154; 3.L.231.157; 3.L.231.166; 3.L.231.169;
3.L.231.172; 3.L.231.175; 3.L.231.240; 3.L.231.244; 3.L.236.228; 3.L.236.229;
3.L.236.230; 3.L.236.231; 3.L.236.236; 3.L.236.237; 3.L.236.238; 3.L.236.239;
3.L.236.154; 3.L.236.157; 3.L.236.166; 3.L.236.169; 3.L.236.172; 3.L.236.175;
3.L.236.240; 3.L.236.244; 3.L.237.228; 3.L.237.229; 3.L.237.230; 3.L.237.231;
3.L.237.236; 3.L.237.237; 3.L.237.238; 3.L.237.239; 3.L.237.154; 3.L.237.157;
3.L.237.166; 3.L.237.169; 3.L.237.172; 3.L.237.175; 3.L.237.240; 3.L.237.244;
3.L.238.228; 3.L.238.229; 3.L.238.230; 3.L.238.231; 3.L.238.236; 3.L.238.237;
3.L.238.238; 3.L.238.239; 3.L.238.154; 3.L.238.157; 3.L.238.166; 3.L.238.169;
3.L.238.172; 3.L.238.175; 3.L.238.240; 3.L.238.244; 3.L.239.228; 3.L.239.229;
3.L.239.230; 3.L.239.231; 3.L.239.236; 3.L.239.237; 3.L.239.238; 3.L.239.239;
3.L.239.154; 3.L.239.157; 3.L.239.166; 3.L.239.169; 3.L.239.172; 3.L.239.175;
3.L.239.240; 3.L.239.244; 3.L.154.228; 3.L.154.229; 3.L.154.230; 3.L.154.231;
3.L.154.236; 3.L.154.237; 3.L.154.238; 3.L.154.239; 3.L.154.154; 3.L.154.157;
3.L.154.166; 3.L.154.169; 3.L.154.172; 3.L.154.175; 3.L.154.240; 3.L.154.244;
3.L.157.228; 3.L.157.229; 3.L.157.230; 3.L.157.231; 3.L.157.236; 3.L.157.237;
3.L.157.238; 3.L.157.239; 3.L.157.154; 3.L.157.157; 3.L.157.166; 3.L.157.169;
3.L.157.172; 3.L.157.175; 3.L.157.240; 3.L.157.244; 3.L.166.228; 3.L.166.229;
3.L.166.230; 3.L.166.231; 3.L.166.236; 3.L.166.237; 3.L.166.238; 3.L.166.239;
3.L.166.154; 3.L.166.157; 3.L.166.166; 3.L.166.169; 3.L.166.172; 3.L.166.175;
3.L.166.240; 3.L.166.244; 3.L.169.228; 3.L.169.229; 3.L.169.230; 3.L.169.231;
3.L.169.236; 3.L.169.237; 3.L.169.238; 3.L.169.239; 3.L.169.154; 3.L.169.157;
3.L.169.166; 3.L.169.169; 3.L.169.172; 3.L.169.175; 3.L.169.240; 3.L.169.244;
3.L.172.228; 3.L.172.229; 3.L.172.230; 3.L.172.231; 3.L.172.236; 3.L.172.237;
3.L.172.238; 3.L.172.239; 3.L.172.154; 3.L.172.157; 3.L.172.166; 3.L.172.169;

3.L.172.172; 3.L.172.175; 3.L.172.240; 3.L.172.244; 3.L.175.228; 3.L.175.229;
3.L.175.230; 3.L.175.231; 3.L.175.236; 3.L.175.237; 3.L.175.238; 3.L.175.239;
3.L.175.154; 3.L.175.157; 3.L.175.166; 3.L.175.169; 3.L.175.172; 3.L.175.175;
3.L.175.240; 3.L.175.244; 3.L.240.228; 3.L.240.229; 31.240.230; 3.L.240.231;
3.L.240.236; 3.L.240.237; 3.L.240.238; 3.L.240.239; 3.L.240.154; 3.L.240.157;
3.L.240.166; 3.L.240.169; 3.L.240.172; 3.L.240.175; 3.L.240.240; 3.L.240.244;
3.L.244.228; 3.L.244.229; 3.L.244.230; 3.L.244.231; 3.L.244.236; 3.L.244.237;
3.L.244.238; 3.L.244.239; 3.L.244.154; 3.L.244.157; 3.L.244.166; 3.L.244.169;
3.L.244.172; 3.1-244.175; 3.L.244.240; 3.L.244.244;

Prodrugs of 3.0 3Ø228.228; 3Ø228.229; 3Ø228.230; 3Ø228.231; 3Ø228.236; 3Ø228.237;
3Ø228.238; 3Ø228.239; 3Ø228.154; 3Ø228.157; 3Ø228.166; 3Ø228.169;
3Ø228.172; 3Ø228.175; 3Ø228.240; 3Ø228.244; 3Ø229.228; 3Ø229.229;
3Ø229.230; 3Ø229.231; 3Ø229.236; 3Ø229.237; 3Ø229.238; 3Ø229.239;
3Ø229.154; 3Ø229.157; 3Ø229.166; 3Ø229.169; 3Ø229.172; 3Ø229.175;
3Ø229.240; 3Ø229.244; 3Ø230.228; 3Ø230.229; 3Ø230.230; 3Ø230.231;
3Ø230.236; 3Ø230.237; 3Ø230.238; 3Ø230.239; 3Ø230.154; 3Ø230.157;
3Ø230.166; 3Ø230.169; 3Ø230.172; 3Ø230.175; 3Ø230.240; 3Ø230.244;
3Ø231.228; 3Ø231.229; 3Ø231.230; 3Ø231.231; 3Ø231.236; 3Ø231.237;
3Ø231.238; 3Ø231.239; 3Ø231.154; 3Ø231.157; 3Ø231.166; 3Ø231.169;
3Ø231.172; 3Ø231.175; 3Ø231.240; 3Ø231.244; 3Ø236.228; 3Ø236.229;
3Ø236.230; 3Ø236.231; 3Ø236.236; 3Ø236.237; 3Ø236238; 3Ø236.239;
3Ø236.154; 3Ø236.157; 3Ø236.166; 3Ø236.169; 3Ø236.172; 3Ø236.175;
3Ø236.240; 3Ø236.244; 3Ø237.228; 3Ø237.229; 3Ø237.230; 3Ø237.231;
3Ø237.236; 3Ø237.237; 3Ø237.238; 3Ø237.239; 3Ø237.154; 3Ø237.157;
3Ø237.166; 3Ø237.169; 3Ø237.172; 3Ø237.175; 3Ø237.240; 3Ø237.244;
3Ø238.228; 3Ø238.229; 3Ø238.230; 3Ø238.231; 3Ø238.236; 3Ø238.237;
3Ø238.238; 3Ø238.239; 3Ø238.154; 3Ø238.157; 3Ø238.166; 3Ø238.169;
3Ø238.172; 3Ø238.175; 3Ø238.240; 3Ø238.244; 3Ø239.228; 3Ø239.229;
3Ø239.230; 3Ø239.231; 3Ø239.236; 3Ø239.237; 3Ø239.238; 3Ø239.239;

3Ø239.154; 3Ø239.157; 3Ø239.166; 3Ø239.169; 3Ø239.172; 3Ø239.175;
3Ø239.240; 3Ø239.244; 3Ø154.228; 3Ø154.229; 3Ø154.230; 3Ø154.231;
3Ø154.236; 3Ø154.237; 3Ø154.238; 3Ø154.239; 3Ø154.154; 3Ø154.157;
3Ø154.166; 3Ø154.169; 3Ø154.172; 3Ø154.175; 3Ø154.240; 3Ø154.244;
3Ø157.228; 3Ø157.229; 3Ø157.230; 3Ø157.231; 3Ø157.236; 3Ø157.237;
3Ø157.238; 3Ø157.239; 3Ø157.154; 3Ø157.157; 3Ø157.166; 3Ø157.169;
3Ø157.172; 3Ø157.175; 3Ø157.240; 3Ø157.244; 3Ø166.228; 3Ø166.229;
3Ø166.230; 3Ø166.231; 3Ø166.236; 3Ø166.237; 3Ø166.238; 3Ø166.239;
3Ø166.154; 3Ø166.157; 3Ø166.166; 3Ø166.169; 3Ø166.172; 3Ø166.175;
3Ø166.240; 3Ø166.244; 3Ø169.228; 3Ø169.229; 3Ø169.230; 3Ø169.231;
3Ø169.236; 3Ø169.237; 3Ø169.238; 3Ø169.239; 3Ø169.154; 3Ø169.157;
3Ø169.166; 3Ø169.169; 3Ø169.172; 3Ø169.175; 3Ø169.240; 3Ø169.244;
3Ø172.228; 3Ø172.229; 3Ø172.230; 3Ø172.231; 3Ø172.236; 3Ø172.237;
3Ø172.238; 3Ø172.239; 3Ø172.154; 3Ø172.157; 3Ø172.166; 3Ø172.169;
3Ø172.172; 3Ø172.175; 3Ø172.240; 3Ø172.244; 3Ø175.228; 3Ø175.229;
3Ø175.230; 3Ø175.231; 3Ø175.236; 3Ø175.237; 3Ø175.238; 3Ø175.239;
3Ø175.154; 3Ø175.157; 3Ø175.166; 3Ø175.169; 3Ø175.172; 3Ø175.175;
3Ø175.240; 3Ø175.244; 3Ø240.228; 3Ø240.229; 3Ø240.230; 3Ø240.231;
3Ø240.236; 3Ø240.237; 3Ø240.238; 3Ø240.239; 3Ø240.154; 3Ø240.157;
3Ø240.166; 3Ø240.169; 3Ø240.172; 3Ø240.175; 3Ø240.240; 3Ø240.244;
3Ø244.228; 3Ø244.229; 3Ø244:230; 3Ø244.231; 3Ø244.236; 3Ø244.237;
3Ø244.238; 3Ø244.239; 3Ø244.154; 3Ø244.157; 3Ø244.166; 3Ø244.169;
3Ø244.172; 3Ø244.175; 3Ø244.240; 3Ø244.244;

Prodrugs of 3.P
3.P.228.228; 3.P.228.229; 3.P.228.230; 3.P.228.231; 3.P.228.236; 3.P.228.237;
3.P.228.238; 3.P.228.239; 3.P.228.154; 3.P.228.157; 3.P.228.166; 3.P.228.169;
3.P.228.172; 3.P.228.175; 3.P.228.240; 3.P.228.244; 3.P.229.228; 3.P.229.229;
3.P.229.230; 3.P.229.231; 3.P.229.236; 3.P.229.237; 3.P.229.238; 3.P.229.239;
3.P.229.154; 3.P.229.157; 3.P.229.166; 3.P.229.169; 3.P.229.172; 3.P.229.175;
3.P.229.240; 3.P.229.244; 3.P.230.228; 3.P.230.229; 3.P.230.230; 3.P.230.231;

3.P.230.236; 3.P.230.237; 3.P.230.238; 3.P.230.239; 3.P.230.154; 3.P.230.157;
3.P.230.166; 3.P.230.169; 3.P.230.172; 3.P.230.175; 3.P.230.240; 3.P.230.244;
3.P.231.228; 3.P.231.229; 3.P.231.230; 3.P.231.231; 3.P.231.236; 3.P.231.237;
3.P.231.238; 3.P.231.239; 3.P.231.154; 3.P.231.157; 3.P.231.166; 3.P.231.169;
3.P.231.172; 3.P.231.175; 3.P.231.240; 3.P.231.244; 3.P.236.228; 3.P.236.229;
3.P.236.230; 3.P.236.231; 3.P.236.236; 3.P.236.237; 3.P.236.238; 3.P.236.239;
3.P.236.154; 3.P.236.157; 3.P.236.166; 3.P.236.169; 3.P.236.172; 3.P.236.175;
3.P.236.240; 3.P.236.244; 3.P.237.228; 3.P.237.229; 3.P.237.230; 3_P.237.231;
3.P.237.236; 3.P.237.237; 3.P.237.238; 3.P.237.239; 3.P.237.154; 3.P.237.157;
3.P.237.166; 3.P.237.169; 3.P.237.172; 3.P.237.175; 3.P.237.240; 3.P.237.244;
3.P.238.228; 3.P.238.229; 3.P.238.230; 3.P.238.231; 3.P.238.236; 3.P.238.237;
3.P.238.238; 3.P.238.239; 3.P.238.154; 3.P.238.157; 3.P.238.166; 3.P.238.169;
3.P.238.172; 3.P.238.175; 3.P.238.240; 3.P.238.244; 3.P.239.228; 3.P.239.229;
3.P.239.230; 3.P.239.231; 3.P.239.236; 3.P.239.237; 3.P.239.238; 3.P.239.239;
3.P.239.154; 3.P.239.157; 3.P.239.166; 3.P.239.169; 3.P.239.172; 3.P.239:175;
3.P.239.240; 3.P.239.244; 3.P.154.228; 3.P.154.229; 3.P.154.230; 3.P.154.231;
3.P.154.236; 3.P.154.237; 3.P.154.238; 3.P.154.239; 3.P.154.154; 3.P.154.157;
3.P.154.166; 3.P.154.169; 3.P.154.172; 3.P.154.175; 3.P.154.240; 3.P.154.244;
3.P.157.228; 3.P.157.229; 3.P.157.230; 3.P.157.231; 3.P.157.236; 3.P.157.237;
3.P.157.238; 3.P.157.239; 3:P.157.154; 3.P.157.157; 3.P.157.166; 3.P.157.169;
3.P.157.172; 3.P.157.175; 3.P.157.240; 3.P.157.244; 3.P.166.228; 3.P.166.229;
3.P.166.230; 3.P.166.231; 3.P.166.236; 3.P.166.237; 3.P.166.238; 3.P.166.239;
3.P.166.154; 3.P.166.157; 3.P.166.166; 3.P.166.169; 3.P.166.172; 3.P.166.175;
3.P.166.240; 3.P.166.244; 3.P.169.228; 3.P.169.229; 3.P.169.230; 3.P.169.231;
3.P.169.236; 3.P.169.237; 3.P.169.238; 3.P.169.239; 3.P.169.154; 3.P.169.157;
3.P.169.166; 3.P.169.169; 3.P.169.172; 3.P.169.175; 3.P.169.240; 3.P.169.244;
-3.P.172.228; 3.P.172.229; 3.P.172.230; 3.P.172.231; 3.P.172.236; 3.P.172.237;
3.P.172.238; 3.P.172.239; 3.P.172.154; 3.P.172.157;.3.P.172.166; 3.P.172.169;
3.P.172.172; 3.P.172.175; 3.P.172.240; 3.P.172.244; 3.P.175.228; 3.P.175.229;
3.P.175.230; 3.P.175.231; 3.P.175.236; 3.P.175.237; 3.P.175.238; 3.P.175.239;
3.P.175.154; 3.P.175.157; 3.P.175.166; 3.P.175.169; 3.P.175.172; 3.P.175.175;

3.P.175.240; 3.P.175.244; 3.P.240.228; 3.P.240.229; 3.P.240.230; 3.P.240.231;
3.P.240.236; 3.P.240.237; 3.P.240.238; 3.P.240.239; 3.P.240.154; 3.P.240.157;
3.P.240.166; 3.P.240.169; 3.P.240.172; 3.P.240.175; 3.P.240-240; 3.P.240.244;
3.P.244.228; 3.P.244.229; 3.P.244.230; 3.P.244.231; 3.P.244.236; 3.P.244.237;
3.P.244.238; 3.P.244.239; 3.P.244.154; 3.P.244.157; 3.P.244.166; 3.P.244.169;
3.P.244.172; 3.P244.175; 3.P.244.240; 3.P.244.244;
Prodrugs of 3.U
3.U.228.228; 3.U.228.229; 3.U.228.230; 3.U.228.231; 3.U.228.236; 3.U.228.237;
3.U.228.238; 3.U.228.239; 3.U.228.154; 3.U.228.157; 3.U.228.166; 3.U.228.169;
3.U.228.172; 3.U.228.175; 3.U.228.240; 3.U.228.244; 3.U.229.228; 3.U.229.229;
3.U.229.230; 3.U.229.231; 3.U.229.236; 3.U.229.237; 3.U.229.238; 3.U.229.239;
3.U.229.154; 3.U.229.157; 3.U.229.166; 3.U.229.169; 3.U.229.172; 3.U.229.175;
3.U.229.240; 3.U.229.244; 3.U.230.228; 3.U.230.229; 3.U.230.230; 3.U.230.231;
3.U.230.236; 3.U.230.237; 3.U.230.238; 3.U.230.239; 3.U.230.154; 3.U.230.157;
3.U.230.166; 3.U.230.169; 3.U.230.172; 3.U.230.175; 3.U.230.240; 3.U.230.244;
3.U.231.228; 3.U.231.229; 3.U.231.230; 3.U.231.231; 3.U.231.236; 3.U.231.237;
3.U.231.238; 3.U.231.239; 3.U.231.154; 3.U.231.157; 3.U.231.166; 3.U.231.169;
3.U.231.172; 3.U.231.175; 3.U.231.240; 3.U.231.244; 3.U.236.228; 3.U.236.229;
3.U.236.230; 3.U.236.231; 3.U.236.236; 3.U.236.237; 3.U.236.238; 3.U.236.239;
3.U.236.154; 3.U.236.157; 3.U.236.166; 3.U.236.169; 3.U.236.172; 3.U.236.175;
3.U.236.240; 3.U.236.244; 3.U.237.228; 3.U.237.229; 3.U.237.230; 3.U.237.231;
3.U.237.236; 3.U.237.237; 3.U.237.238; 3.U.237.239; 3.U.237.154; 3.U.237.157;
3.U.237.166; 3.U.237.169; 3.U.237.172; 3.U.237.175; 3.U.237.240; 3.U.237.244;
3.U.238.228; 3.U.238.229; 3.U.238.230; 3.U.238.231; 3.U.238.236; 3.U.238.237;
3.U.238.238; 3.U.238.239; 3.U.238.154; 3.U.238.157; 3.U.238.166; 3.U.238.169;
3.U.238.172; 3.U.238.175; 3.U.238.240; 3.U.238.244; 3.U.239.228; 3.U.239.229;
3.U.239.230; 3.U.239.231; 3.U.239.236; 3.U.239.237; 3.U.239.238; 3.U.239.239;
3.U.239.154; 3.U.239.157; 3.U.239.166; 3.U.239.169; 3.U.239.172; 3.U.239.175;
3.U.239.240; 3.U.239.244; 3.U.154.228; 3.U.154.229; 3.U.154.230; 3.U.154.231;
3.U.154.236; 3.U_154.237; 3.U.154.238; 3.U.154.239; 3.U.154.154; 3.U.154.157;

3.U.154.166; 3.U.154.169; 3.U.154.172; 3.U.154.175; 3.U.154.240; 3.U.154.244;
3.U.157.228; 3.U.157.229; 3.U.157.230; 3.U.157.231; 3.U.157.236; 3.U.157.237;
3.U.157.238; 3.U.157.239; 3.U.157.154; 3.U.157.157; 3.U.157.166; 3.U.157.169;
3.U.157.172; 3.U.157.175; 3.U.157.240; 3.U.157.244; 3.U.166.228; 3.U.166.229;
3.U.166.230; 3.U.166.231; 3.U.166.236; 3.U.166.237; 3.U.166.238; 3.U.166.239;
3.U.166.154; 3.U.166.157; 3.U.166.166; 3.U.166.169; 3.U.166.172; 3.U.166.175;
3.U.166.240; 3.U.166.244; 3.U.169.228; 3.U.169.229; 3.U.169.230; 3.U.169.231;
3.U.169.236; 3.U.169.237; 3.U.169.238; 3.U.169.239; 3.U.169.154; 3.U.169.157;
3.U.169.166; 3.U.169.169; 3.U.169.172; 3.U.169.175; 3.U.169.240; 3.U.169.244;
3.U.172.228; 3.U.172.229; 3.U.172.230; 3.U.172.231; 3.U.172.236; 3.U.172.237;
3.U.172.238; 3.U.172.239; 3.U.172.154; 3.U.172.157; 3.U.172.166; 3.U.172.169;
3.U.172.172; 3.U.172.175; 3.U.172.240; 3.U.172.244; 3.U.175.228; 3.U.175.229;
3.U.175.230; 3.U.175.231; 3.U.175.236; 3.U.175.237; 3.U.175.238; 3.U.175.239;
3.U.175.154; 3.U.175.157; 3.U.175.166; 3.U.175.169; 3.U.175.172; '3.U.175.175;
3.U.175.240; 3.U.175.244; 3.U.240.228; 3.U.240.229; 3.U.240.230; 3.U.240.231;
3.U.240.236; 3.U.240.237; 3.U.240.238; 3.U.240.239; 3.U.240.154; 3.U.240.157;
3.U.240.166; 3.U.240.169; 3.U.240.172; 3.U.240.175; 3.U.240.240; 3.U.240.244;
3.U.244.228; 3.U.244.229; 3.U.244.230; 3.U.244.231; 3.U.244.236; 3.U.244.237;
3.U.244.238; 3.U.244.239; 3.U.244.154; 3.U.244.157; 3.U.244.166; 3.U.244.169;
3.U.244.172; 3.U.244.175; 3.U.244.240; 3.U.244.244;

Prodrugs of 3.W
3.W.228.228; 3.W.228.229; 3.W.228.230; 3.W.228.231; 3.W.228.236; 3.W.228.237;
3.W.228.238; 3.W.228.239; 3.W.228.154; 3.W.228.157; 3.W.228.166; 3.W_228.169;
3.W.228.172; 3.W.228.175; 3.W.228.240; 3.W.228.244; 3.W.229.228; 3.W.229.229;
3.W.229.230; 3.W.229.231; 3.W.229.236; 3.W.229.237; 3.W.229.238; 3.W.229.239;
3.W.229.154; 3.W.229.157; 3.W.229.166; 3.W.229.169; 3.W.229.172; 3.W.229.175;
3.W.229.240; 3.W.229.244; 3.W.230.228; 3.W.230.229; 3.W.230.230; 3.W.230.231;
3.W.230.236; 3.W.230.237; 3.W.230.238; 3.W.230.239; 3.W.230.154; 3.W.230.157;
3.W.230.166; 3.W.230.169; 3.W.230.172; 3.W.230.175; 3.W.230.240; 3.W.230.244;
3.W.231.228; 3.W.231.229; 3.W.231.230; 3.W.231.231; 3.W.231.236; 3.W.231.237;

3.W.231.238; 3.W.231.239; 3.W.231.154; 3.W.231.157; 3.W.231.166; 3.W.231.169;
3.W.231.172; 3.W.231.175; 3.W.231.240; 3.W.231.244; 3.W.236.228; 3.W.236.229;
3.W.236.230; 3.W.236.231; 3.W.236.236; 3.W.236.237; 3.W.236.238; 3.W.236.239;
3.W.236.154; 3.W.236.157; 3.W.236.166; 3.W.236.169; 3.W.236.172; 3.W.236.175;
3.W.236.240; 3.W.236.244; 3.W.237.228; 3.W.237.229; 3.W.237.230; 3.W.237.231;
3.W.237.236; 3.W.237.237; 3_W.237.238; 3.W.237.239; 3.W.237.154; 3.W.237.157;
3.W.237.166; 3.W.237.169; 3.W.237.172; 3.W.237.175; 3.W.237.240; 3.W.237.244;
3.W.238.228; 3.W.238.229; 3.W.238.230; 3.W.238.231; 3.W.238.236; 3.W.238.237;
3.W.238.238; 3.W.238.239; 3.W.238.154; 3.W.238.157; 3.W.238.166; 3.W.238.169;
3.W.238.172; 3.W.238.175; 3.W.238.240; 3.W.238.244; 3.W.239.228; 3.W.239.229;
3.W.239.230; 3.W.239.231; 3.W.239.236; 3.W.239.237; 3.W.239.238; 3.W.239.239;
3.W.239.154; 3.W.239.157; 3.W.239.166; 3.W.239.169; 3.W.239.172; 3.W.239.175;
3.W.239.240; 3.W.239.244; 3.W.154.228; 3.W.154.229; 3.W.154.230; 3.W.154.231;
3.W.154.236; 3.W.154.237; 3.W.154.238; 3.W.154.239; 3.W.154.154; 3.W.154.157;
3.W.154.166; 3.W.154.169; 3.W.154.172; 3.W.154.175; 3.W.154.240; 3.W.154.244;
3.W.157.228; 3.W.157.229; 3.W.157.230; 3.W.157.231; 3.W.157.236; 3.W.157.237;
3.W.157.238; 3.W.157.239; 3.W.157.154; 3.W.157.157; 3.W.157.166; 3.W.157.169;
3.W.157.172; 3.W.157.175; 3.W.157.240; 3.W.157.244; 3.W.166.228; 3.W.166.229;
3.W.166.230; 3.W.166.231; 3.W.166.236; 3.W.166.237; 3.W.166.238; 3.W.166.239;
3.W.166.154; 3.W.166.157; 3.W.166.166; 3.W.166.169; 3.W.166.172; 3.W.166.175;
3.W.166.240; 3.W.166.244; 3.W.169.228; 3.W.169.229; 3.W.169.230; 3.W.169.231;
3.W.169.236; 3.W.169.237; 3.W.169.238; 3.W.169.239; 3.W.169.154; 3.W.169.157;
3.W.169.166; 3.W.169.169; 3.W.169.172; 3.W.169.175; 3.W.169.240; 3.W.169.244;
3.W.172.228; 3.W.172.229; 3.W.172.230; 3.W.172.231; 3.W.172.236; 3.W.172.237;
3.W.172.238; 3.W.172.239; 3.W.172.154; 3.W.172.157; 3.W.172.166; 3.W.172.169;
3.W.172.172; 3.W.172.175; 3.W.172.240; 3.W.172.244; 3.W.175.228; 3.W.175.229;
3.W.175.230; 3.W.175.231; 3.W.175.236; 3.W.175.237; 3.W.175.238; 3.W.175.239;
3.W.175.154; 3.W.175.157; 3.W.175.166; 3.W.175.169; 3.W.175.172; 3.W.175.175;
3.W.175.240; 3.W.175.244; 3.W.240.228; 3.W.240.229; 3.W.240.230; 3.W.240.231;
3.W.240.236; 3.W.240.237; 3.W.240.238; 3.W.240.239; 3.W.240.154; 3.W.240.157;
-35 3.W.240.166; 3.W.240.169; 3.W.240.172; 3.W.240.175; 3.W.240.240;
3.W.240.244;

3.W.244.228; 3.W.244.229; 3.W.244.230; 3.W.244.231; 3.W.244.236; 3.W.244.237;
3.W.244.238; 3.W.244.239; 3.W.244.154; 3.W.244.157; 3.W.244.166; 3.W.244.169;
3.W.244.172; 3.W.244.175; 3.W.244.240; 3.W.244.244;

Prodrugs of 3.Y
3.Y.228.228; 3.Y.228.229; 3.Y.228.230; 3.Y.228.231; 3.Y.228.236; 3.Y.228.237;
3.Y.228.238; 3.Y.228.239; 3.Y.228.154; 3.Y.228.157; 3.Y.228.166; 3.Y.228.169;
3.Y.228.172; 3.Y.228.175; 3.Y.228.240; 3.Y.228.244; 3.Y.229.228; 3.Y.229.229;
3.Y.229.230; 3.Y.229.231; 3.Y.229.236; 3.Y.229.237; 3.Y.229.238; 3.Y.229.239;
3.Y.229.154; 3.Y.229.157; 3.Y.229.166; 3.Y.229.169; 3.Y.229.172; 3.Y.229.175;
3.Y.229.240; 3.Y.229.244; 3.Y.230.228; 3.Y.230.229; 3.Y.230.230; 3.Y.230.231;
3.Y.230.236; 3.Y.230.237; 3.Y.230.238; 3.Y.230.239; 3.Y.230.154; 3.Y.230.157;
3.Y.230.166; 3.Y.230.169; 3.Y.230.172; 3.Y.230.175; 3.Y.230.240; 3.Y.230.244;
3.Y.231.228; 3.Y.231.229; 3.Y.231.230; 3.Y.231.231; 3.Y.231.236; 3.Y.231.237;
3.Y.231.238; 3.Y.231.239; 3.Y.231.154; 3.Y.231.157; 3.Y.231.166; 3.Y.231.169;
3.Y.231.172; 3.Y.231.175; 3.Y.231.240; 3.Y.231.244; 3.Y.236.228; 3.Y.236.229;
3.Y.236.230; 3.Y.236.231; 3.Y.236.236; 3.Y.236.237; 3.Y.236.238; 3.Y.236.239;
3.Y.236.154; 3.Y.236.157; 3.Y.236.166; 3.Y.236.169; 3.Y.236.172; 3.Y.236.175;
3.Y.236.240; 3.Y.236.244; 3.Y.237.228; 3.Y.237.229; 3.Y.237.230; 3.Y.237.231;
3.Y.237.236; 3.Y.237.237; 3.Y.237.238; 3.Y.237.239; 3.Y.237.154; 3.Y.237.157;
3.Y.237.166; 3.Y.237.169; 3.Y.237.172; 3.Y.237.175; 3.Y.237.240; 3.Y.237.244;
3.Y.238.228; 3.Y.238.229; 3.Y.238.230; 3.Y.238.231; 3.Y.238.236; 3.Y.238.237;
3.Y.238.238; 3.Y.238.239; 3.Y.238.154; 3.Y.238.157; 3.Y.238.166; 3.Y.238.169;
3.Y.238.172; 3.Y.238.175; 3.Y.238.240; 3.Y.238.244; 3.Y239.228; 3.Y.239.229;
3.Y.239.230; 3.Y.239.231'; 3.Y.239.236; 3.Y.239.237; 3.Y.239.238; 3.Y.239.239;
3.Y.239.154; 3.Y.239.157; 3.Y.239.166; 3.Y.239.169; 3.Y.239.172; 3.Y.239.175;
3.Y.239.240; 3.Y.239.244; 3.Y.154.228; 3.Y.154.229; 3.Y.154.230; 3.Y.154.231;
3.Y.154.236; 3.Y.154.237; 3.Y.154.238; 3.Y.154.239; 3.Y.154.154; 3.Y.154.157;
3.Y.154.166; 3.Y.154.169; 3.Y.154.172; 3.Y.154.175; 3.Y.154.240; 3.Y.154.244;
3.Y.157.228; 3.Y.157.229; 3.Y.157.230; 3.Y.157.231; 3.Y.157.236; 3.Y.157.237;
3.Y.157.238; 3.Y.157.239; 3.Y.157.154; 3.Y.157.157; 3.Y.157.166; 3.Y.157.169;

3.Y.157.172; 3.Y.157.175; 3.Y.157.240; 3.Y.157.244; 3.Y.166.228; 3.Y.166.229;
3.Y.166.230; 3.Y.166.231; 3.Y.166.236; 3.Y.166.237; 3.Y.166.238; 3.Y.166.239;
3.Y.166.154; 3.Y.166.157; 3.Y.166.166; 3.Y.166.169; 3.Y.166.172; 3.Y.166.175;
3.Y.166.240; 3.Y.166.244; 3.Y.169.228; 3.Y.169.229; 3.Y.169.230; 3.Y.169.231;
3.Y.169.236; 3.Y.169.237; 3.Y.169.238; 3.Y.169.239; 3.Y.169.154; 3.Y.169.157;
3.Y.169.166; 3.Y.169.169; 3.Y.169.172; 3.Y.169.175; 3.Y.169.240; 3.Y.169.244;
3.Y.172.228; 3.Y.172.229; 3.Y.172.230; 3.Y.172.231; 3.Y.172.236; 3.Y.172.237;
3.Y.172.238; 3.Y.172.239; 3.Y.172.154; 3.Y.172.157; 3.Y.172.166; 3.Y.172.169;
3.Y.172.172; 3.Y.172.175; 3.Y.172.240; 3.Y.172.244; 3.Y.175.228; 3.Y.175.229;
3.Y.175.230; 3.Y.175.231; 3.Y.175.236; 3.Y.175.237; 3.Y.175.238; 3.Y.175.239;
3.Y.175.154; 3.Y.175.157; 3.Y.175.166; 3_Y.175:169; 3.Y.175.172; 3.Y.175.175;
3.Y.175.240; 3.Y.175.244; 3.Y.240.228; 3.Y.240.229; 3.Y.240.230; 3.Y.240.231;
3.Y.240.236; 3.Y.240.237; 3.Y.240.238; 3.Y.240.239; 3.Y.240.154; 3.Y.240.157;
3.Y.240.166; 3.Y.240.169; 3.Y.240.172; 3.Y.240.175; 3.1.240.240; 3.Y.240.244;
3.Y.244.228; 3.Y.244.229; 3.Y.244.230; 3.Y.244.231; 3.Y.244.236; 3.Y.244.237;
3.Y.244.238; 3.Y.244.239; 3.Y.244.154; 3.Y.244.157; 3.Y.244.166; 3.Y.244.169;
3.Y.244.172; 3.Y.244.175; 3.Y.244.240; 3.Y.244.244;

Prodrugs of 4.B
4.B.228.228; 4.B.228.229; 4.B.228.230; 4.B.228.231; 4.B.228.236; 4.B.228.237;
4.B.228.238; 4.B.228.239; 4.B.228.154; 4.B.228.157; 4.B.228.166; 4.B.228.169;
4.B.228.172; 4.B.228.175; 4.B.228.240; 4.B.228.244; 4.B.229.228; 4.B.229.229;
4.B.229.230; 4.B.229.231; 4.B.229.236; 4.B.229.237; 4.B.229.238; 4.B.229.239;
4.B.229.154; 4.B.229.157; 4.B.229.166; 4.B.229.169; 4.B.229.172; 4.B.229.175;
4.B.229.240; 4.B.229.244; 4.B.230.228; 4.B.230.229; 4.B.230.230; 4.B.230.231;
4.B.230.236; 4.B.230.237; 4.B.230.238; 4.B.230.239; 4.B.230.154; 4.B.230.157;
4.B.230.166; 4.B.230.169; 4.B.230.172; 4.B.230.175; 4.B.230.240; 4.B.230.244;
4.B.231.228; 4.B.231.229; 4.B.231.230; 4.B.231.231; 4.B.231.236; 4.B.231.237;
4.B.231.238; 4.B.231.239; 4.B.231.154; 4.B.231.157; 4.B.231.166; 4.B.231.169;
4.B.231.172; 4.B.231.175; 4.B.231.240; 4.B.231.244; 4.B.236.228; 4.B.236.229;
4.B.236.230; 4.B.236.231; 4.B.236.236; 4.B.236.237; 4.B.236.238; 4.B.236.239;

4.B.236.154; 4.B.236.157; 4.B.236.166; 4.B.236.169; 4.B.236.172; 4.B.236.175;
4.B.236.240; 4.B.236.244; 4.B.237.228; 4.B.237.229; 4.B.237.230; 4.B.237.231;
4.B.237.236; 4.B.237.237; 4.B.237.238; 4.B.237.239; 4.B.237.154; 4.B.237.157;
4.B.237.166; 4.B.237.169; 4.B.237.172; 4.B.237.175; 4.B.237.240; 4.B.237.244;
4.B.238.228; 4.B.238.229; 4.B.238.230; 4.B.238.231; 4.B.238.236; 4.B.238.237;
4.B.238.238; 4.B.238.239; 4.B.238.154; 4.B.238.157; 4.B.238.166; 4.B.238.169;
4.B.238.172; 4.B.238.175; 4.B.238.240; 4.B.238.244; 4.B.239.228; 4.B.239.229;
4.B.239.230; 4.B.239.231; 4.B.239.236; 4.B.239.237; 4.B.239.238; 4.B.239.239;
4.B.239.154; 4.B.239.157; 4.B.239.166; 4.B.239.169; 4.B.239.172; 4.B.239.175;
4.B.239.240; 4.B.239.244; 4.B.154.228; 4.B.154.229; 4.B.154.230; 4.B.154.231;
4.B.154.236; 4.B.154.237; 4.B.154.238; 4.B.154.239; 4.B.154.154; 4.B.154.157;
4.B.154.166; 4.B.154.169; 4.B.154.172; 4.B.154.175; 4.B.154.240; 4.B.154.244;
4.B.157.228; 4.B.157.229; 4.B.157.230; 4.B.157.231; 4.B.157.236; 4.B.157.237;
4.B.157.238; 4.B.157.239; 4.B.157.154; 4.B.157.157; 4.B.157.166; 4.B.157.169;
4.B.157.172; 4.B.157.175; 4.B.157.240; 4.B.157.244; 4.B.166.228; 4.B.166.229;
4.B.166.230; 4.B.166.231; 4.B.166.236; 4.B.166.237; 4.B.166.238; 4.B.166.239;
4.B.166.154; 4.B.166.157; 4.B.166.166; 4.B.166.169; 4.B.166.172; 4.B.166.175;
4.B.166.240; 4.B.166.244; 4.B.169.228; 4.B.169.229; 4.B.169.230; 4.B.169.231;
4.B.169.236; 4.B.169.237; 4.B.169.238; 4.B.169.239; 4.B.169.154; 4.B.169.157;
4.B.169.166; 4.B.169.169; 4.B.169.172; 4.B.169.175; 4.B.169.240; 4.B.169.244;
4.B.172.228; 4.B.172.229; 4.B.172.230; 4.B.172.231; 4.B.172.236; 4.B.172.237;
. 4.B.172.238; 4.B.172.239; 4.B.172.154; 4.B.172.157; 4.B.172.166;
4.B.172.169;
4.B.172.172; 4.B.172.175; 4.B.172.240; 4.B.172.244; 4.B.175.228; 4.B.175.229;
4.B.175.230; 4.B.175.231; 4.B.175.236; 4.B.175.237; 4.B.175.238; 4.B.175.239;
4.B.175.154; 4.B.175.157; 4.B.175.166; 4.B.175.169; 4.B.175.172; 4.B.175.175;
4.B.175.240; 4.B.175.244; 4.B.240.228; 4.B.240.229; 4.B.240.230; 4.B.240.231;
4.B.240.236; 4.B.240.237; 4.B.240.238; 4.B.240.239; 4.B.240.154; 4.B.240.157;
4.B.240.166; 4.B.240.169; 4.B.240.172; 4.B.240.175; 4.B.240.240; 4.B.240.244;
4.B.244.228; 4.B244.229; 4.B.244.230; 4.B.244.231; 4.B.244.236; 4.B.244.237;
4.B.244.238; 4.B.244.239; 4.B.244.154; 4.B.244.157; 4.B.244.166; 4.B.244.169;
4.B.244.172; 4.B.244.175; 4.B.244.240; 4.B.244.244;

Prodrugs of 4.D
4.D.228.228; 4.D.228.229; 4.D.228.230; 4.D.228.231; 4.D.228.236; 4.D.228.237;
4.D.228.238; 4.D.228.239; 4.D.228.154; 4.D.228.157; 4.D.228.166; 4.D.228.169;
4.D.228.172; 4.D.228.175; 4.D.228.240; 4.D.228.244; 4.D.229.228; 4.D.229.229;
4.D.229.230; 4.D.229.231; 4.D.229.236; 4.D.229.237; 4.D.229.238; 4.D.229.239;
4.D.229.154; 4.D.229.157; 4.D.229.166; 4.D.229.169; 4.D.229.172; 4.D.229.175;
4.D.229.240; 4.D.229.244; 4.D.230.228; 4.D.230.229; 4.D.230.230; 4.D.230.231;
4.D.230.236; 4.D.230.237; 4.D.230.238; 4.D.230.239; 4.D.230.154; 4.D.230.157;
4.D.230.166; 4.D.230.169; 4.D.230.172; 4.D.230.175; 4.D.230.240; 4.D.230.244;
4.D.231.228; 4.D.231.229; 4.D.231.230; 4.D.231.231; 4.D_231.236; 4.D.231.237;
4.D.231.238; 4.D.231.239; 4.D.231.154; 4.D.231.157; 4.D.231.166; 4.D.231.169;
4.D.231.172; 4.D.231.175; 4.D.231.240; 4.D.231.244; 4.D.236.228; 4.D.236.229;
4.D.236.230; 4.D.236.231; 4.D.236.236; 4.D.236.237; 4.D.236.238; 4.D.236.239;
4.D.236.154; 4.D.236.157; 4.D.236.166; 4.D.236.169; 4.D.236.172; 4.D.236.175;
4.D.236.240; 4.D.236.244; 4.D.237.228; 4.D.237.229; 4.D.237.230; 4.D.237.231;
4.D.237.236; 4.D.237.237; 4.D.237.238; 4.D.237.239; 4.D.237.154; 4.D.237.157;
4.D.237.166; 4.D.237.169; 4.D.237.172; 4.D.237.175; 4.D.237:240; 4.D.237.244;
4.D.238.228; 4.D.238.229; 4.D.238.230; 4.D.238.231; 4.D.238.236; 4.D.238.237;
4.D.238.238; 4.D.238.239; 4.D.238.154; 4.D.238.157; 4.D.238.166; 4.D.238.169;
4.D.238.172; 4.D.238.175; 4.D.238.240; 4.D.238.244; 4.D.239.228; 4.D.239.229;
4.D.239.230; 4.D.239.231; 4.D.239.236; 4.D.239.237; 4.D.239.238; 4.D.239.239;
4.D.239.154; 4.D.239.157; 4.D.239.166; 4.D.239.169; 4.D.239.172; 4.D.239.175;
4.D.239.240; 4.D.239.244; 4.D.154.228; 4.D.154.229; 4.D.154.230; 4.D.154.231;
4.D.154.236; 4.D.154.237; 4.D.154.238; 4.D.154.239; 4.D.154.154; 4.D.154.157;
4.D.154.166; 4.D.154.169; 4.D.154.172; 4.D.154.175; 4.D.154.240; 4.D.154.244;
4.D.157.228; 4.D.157.229; 4.D.157.230; 4.D.157.231; 4.D.157.236; 4.D.157.237;
4.D.157.238; 4.D.157.239; 4.D.157.154; 4.D.157.157; 4.D.157.166; 4.D.157.169;
4.D157.172; 4.D.157.175; 4.D.157.240; 4.D.157.244; 4.D.166.228; 4.D.166.229;
4.D.166.230; 4.D.166.231; 4.D.166.236; 4.D.166.237; 4.D.166.238; 4.D.166.239;
4.D.166.154; 4.D.166.157; 4.D.166.166; 4.D.166.169; 4.D.166.172; 4.D.166.175;

4.D.166.240; 4.D.166.244; 4.D.169.228; 4.D.169.229; 4.D.169.230; 4.D.169.231;
4.D.169.236; 4.D.169.237; 4.D.169.238; 4.D.169.239; 4.D.169.154; 4.D.169.157;
4.D.169.166; 4.D.169.169; 4.D.169.172; 4.D.169.175; 4.D.169.240; 4.D.169.244;
4.D.172.228; 4.D.172.229; 4.D.172.230; 4.D.172.231; 4.D.172.236; 4.D.172.237;
4.D.172.238; 4.D.172.239; 4.D.172.154; 4.D.172.157; 4.D.172.166; 4.D.172.169;
4.D:172.172; 4.D.172.175; 4.D.172.240; 4.D.172.244; 4.D.175.228; 4.D.175.229;
4.D.175.230; 4.D.175.231; 4.D.175.236; 4.D.175.237; 4.D.175.238; 4.D.175.239;
4.D.175.154; 4.D.175.157; 4.D.175.166; 4.D.175.169; 4.D.175.172; 4.D.175.175;
4.D.175.240; 4.D.175.244; 4.D.240.228; 4.D.240.229; 4.D.240.230; 4.D.240.231;
4.D.240.236; 4.D.240.237; 4.D.240.238; 4.D.240.239; 4.D.240.154; 4.D.240.157;
4.D.240.166; 4.D.240.169; 4.D.240.172; 4.D.240.175; 4.D.240.240; 4.D.240.244;
4.D.244.228; 4.D.244.229; 4.D.244.230; 4.D.244.231; 4.D.244.236; 4.D.244.237;
4.D.244.238; 4.D.244.239; 4.D.244.154; 4.D.244.157; 4.D.244.166; 4.1i.244.169;
4.D.244.172; 4.D.244.175; 4.D.244.240; 4.D.244.244;

Prodrugs of 4.E
4.E.228.228; 4.E.228.229; 4.E.228.230; 4.E.228.231; 4.E.228.236; 4.E.228.237;
4.E.228.238; 4.E.228.239; 4.E.228.154; 4.E.228.157; 4.E.228.166; 4.E.228.169;
4.E.228.172; 4.E.228.175; 4.E.228.240; 4.E.228.244; 4.E.229.228; 4.E.229.229;
4.E.229.230; 4.E.229.231; 4.E.229.236; 4.E.229.237; 4.E.229.238; 4.E.229.239;
4.E.229.154; 4.E.229.157; 4.E.229.166; 4.E.229.169; 4.E.229.172; 4.E.229.175;
4.E.229.240; 4.E.229.244; 4.E.230.228; 4.E.230.229; 4.E.230.230; 4.E.230.231;
4.E.230.236; 4.E.230.237; 4.E.230.238; 4.E.230.239; 4.E.230.154; 4.E.230.157;
4.E.230.166; 4.E.230.169; 4.E.230.172; 4.E.230.175; 4.E.230.240; 4.E.230.244;
4.E.231.228; 4.E.231.229; 4.E.231.230; 4.E.231.231; 4.E.231.236; 4.E.231.237;
4.E.231.238; 4.E.231.239; 4.E.231.154; 4.E.231.157; 4.E.231.166; 4.E.231..169;
4.E.231.172; 4.E.231.175; 4.E.231.240; 4.E.231.244; 4.E.236.228; 4.E.236.229;
4.E.236.230; 4.E.236.231; 4.E.236.236; 4.E.236.237; 4.E.236.238; 4.E.236.239;
4.E.236.154; 4.E.236.157; 4.E.236.166; 4.E.236.169; 4.E.236.172; 4.E.236.175;
4.E.236.240; 4.E.236.244; 4.E.237.228; 4.E.237.229; 4.E.237.230; 4.E.237.231;
4.E.237.236; 4.E.237.237; 4.E.237.238; 4.E.237.239; 4.E.237.154; 4.E.237.157;

4.E.237.166; 4.E.237.169; 4.E.237.172; 4.E.237.175; 4.E.237.240; 4.E.237.244;
4.E.238.228; 4.E.238.229; 4.E.238.230; 4.E.238.231; 4.E.238.236; 4.E.238.237;
4.E.238.238; 4.E.238.239; 4.E.238.154; 4.E.238.157; 4.E.238.166; 4.E.238.169;
4.E.238.172; 4.E.238.175; 4.E.238.240; 4.E.238.244; 4.E.239.228; 4.E.239.229;
4.E.239.230; 4.E.239.231; 4.E.239.236; 4.E.239.237; 4.E.239.238; 4.E.239.239;
4.E.239.154; 4.E.239.157; 4.E.239.166; 4.E.239.169; 4.E.239.172; 4.E.239.175;
4.E.239.240; 4.E.239.244; 4.E.154.228; 4.E.154.229; 4.E.154.230; 4.E.154.231;
4.E.154.236; 4.E.154.237; 4.E.154.238; 4.E.154.239; 4.E.154.154; 4.E.154.157;
4.E.154.166; 4.E.154.169; 4.E.154.172; 4.E.154.175; 4.E.154.240; 4.E.154.244;
4.E.157.228; 4.E.157.229; 4.E.157.230; 4.E.157.231; 4.E.157.236; 4.E.157.237;
4.E.157.238; 4.E.157.239; 4.E.157.154; 4.E.157.157; 4.E.157.166; 4.E.157.169;
4.E.157.172; 4.E.157.175; 4.E.157.240; 4.E.157.244; 4.E.166.228; 4.E.166.229;
4.E.166.230; 4.E.166.231; 4.E.166.236; 4.E.166.237; 4.E.166.238; 4.E.166.239;
4.E.166.154; 4.E.166.157; 4.E.166.166; 4.E.166.169; 4.E.166.172; 4.E.166.175;
4.E.166.240; 4.E.166.244; 4.E.169.228; 4.E.169.229; 4.E.169.230; 4.E.169.231;
4.E.169.236; 4.E.169.237; 4.E.169.238; 4.E.169.239; 4.E.169.154; 4.E.169.157;
4.E.169.166; 4.E.169.169; 4.E.169.172; 4.E.169.175; 4.E.169.240; 4.E.169.244;
4.E.172.228; 4.E.172.229; 4.E.172.230; 4.E.172.231; 4.E.172.236; 4.E.172.237;
4.E.172.238; 4.E.172.239; 4.E.172.154; 4.E.172.157; 4.E.172.166; 4.E.172.169;
4.E.172.172; 4.E.172.175; 4.E.172.240; 4.E.172.244; 4.E.175.228; 4.E.175.229;
4.E.175.230; 4.E.175.231; 4.E.175.236; 4.E.175.237; 4.E.175.238; 4.E.175.239;
4.E.175.154; 4.E.175.157; 4.E.175.166; 4.E.175.169; 4.E.175.172; 4.E.175.175;
4.E.175.240; 4.E.175.244; 4.E.240.228; 4.E.240.229; 4.E.240.230; 4.E.240.231;
4.E.240.236; 4.E.240.237; 4.E.240.238; 4.E.240.239; 4.E.240.154; 4.E.240.157;
4.E.240.166; 4.E.240.169; 4.E.240.172; 4.E.240.175; 4.E.240.240; 4.E.240.244;
4.E.244.228; 4.E.244.229; 4.E.244.230; 4.E.244.231; 4.E.244.236; 4.E.244.237;
4.E:244.238; 4.E.244.239; 4.E.244.154; 4.E.244.157; 4.E.244.166; 4.E.244.169;
4.E.244.172; 4.E.244.175; 4.E.244.240; 4.E.244.244;

Prodrugs of 4.G

4.G.228.228; 4.G.228.229; 4.G.228.230; 4.G.228.231; 4.G.228.236; 4.G.228.237;
4.G.228.238; 4.G.228.239; 4.G.228.154; 4.G.228.157; 4.G.228.166; 4.G.228.169;
4.G.228.172; 4.G.228.175; 4.G.228.240; 4.G.228.244; 4.G.229.228; 4.G.229.229;
4.G.229.230; 4.G.229.231; 4.G.229.236; 4.G.229.237; 4.G.229.238; 4.G.229.239;
4.G.229.154; 4.G.229.157; 4.G.229.166; 4.G.229.169; 4.G.229.172; 4.G.229.175;
4.G.229.240; 4.G.229.244; 4.G.230.228; 4.G.230.229; 4.G.230.230; 4.G.230.231;
4.G.230.236; 4.G.230.237; 4.G.230.238; 4.G.230.239; 4.G.230.154; 4.G.230.157;
4.G.230.166; 4.G.230.169; 4.G.230.172; 4.G.230.175; 4.G.230.240; 4.G.230.244;
4.G.231.228; 4.G.231.229; 4.G.231.230; 4.G.231.231; 4.G.231.236; 4.G.231.237;
4.G.231.238; 4.G.231.239; 4.G.231.154; 4.G.231.157; 4.G.231.166; 4.G.231.169;
4.G.231.172; 4.G.231.175; 4.G.231.240; 4.G.231.244; 4.G.236.228; 4.G.236.229;
4.G.236.230; 4.G.236.231; 4.G.236.236; 4.G.236.237; 4.G.236.238; 4.G.236.239;
4.G.236.154; 4.G.236.157; 4.G.236.166; 4.G.236.169; 4.G.236.172; 4.G.236.175;
4.G.236.240; 4.G.236.244; 4.G.237.228; 4.G.237.229; 4.G.237.230; 4.G.237.231;
4.G.237.236; 4.G.237.237; 4.G.237.238; 4.G.237.239; 4.G.237.154; 4.G.237.157;
4.G.237.166; 4.G.237.169; 4.G.237.172; 4.G.237.175; 4.G.237.240; 4.G.237.244;
4.G.238.228; 4.G.238.229; 4.G.238.230; 4.G.238.231; 4.G.238.236; 4.G.238.237;
4.G.238.238; 4.G.238.239; 4.G.238.154; 4.G.238.157; 4.G.238.166; 4.G.238:169;
4.G.238.172; 4.G.238.175; 4.G.238.240; 4.G.238.244; 4.G.239.228; 4.G.239.229;
4.G.239.230; 4.G.239.231; 4.G.239.236; 4.G.239.237; 4.G.239.238; 4.G.239.239;
4.G.239.154; 4.G.239.157; 4.G.239.166; 4.G.239.169; 4.G.239.172; 4.G.239.175;
4.G.239.240; 4.G.239.244; 4.G.154.228; 4.G.154.229; 4.G.154.230; 4.G.154.231;
4.G.154.236; 4.G.154.237; 4.G.154.238; 4.G.154.239; 4.G.154.154; 4.G.154.157;
4.G.154.166; 4.G.154.169; 4.G.154.172; 4.G.154.175; 4.G.154.240; 4.G.154.244;
4.G.157.228; 4.G.157.229; 4.G.157.230; 4.G.157.231; 4.G.157.236; 4.G.157.237;
4.G.157:238; 4.G.157.239; 4.G.157.154; 4.G.157.157; 4.G.157.166; 4.G.157.169;
4.G.157.172; 4.G.157.175; 4.G.157.240; 4.G.157.244; 4.G.166.228; 4.G.166.229;
4.G.166.230; 4.G.166.231; 4.G.166.236; 4.G.166.237; 4.G.166.238; 4.G.166.239;
4.G.166.154; 4.G.166.157; 4.G.166.166; 4.G.166.169; 4.G.166.172; 4.G.166.175;
4.G.166.240; 4.G.166.244; 4.G.169.228; 4.G.169.229; 4.G.169.230; 4.G.169.231;
4.G.169.236; 4.G.169.237; 4.G.169.238; 4.G.169.239; 4.G.169.154; 4.G.169.157;

4.G.169.166; 4.G.169.169; 4.G.169.172; 4.G.169.175; 4.G.169.240; 4.G.169.244;
4.G.172.228; 4.G.172.229; 4.G.172.230; 4.G.172.231; 4.G.172.236; 4.G.172.237;
4.G.172.238; 4.G.172.239; 4.G.172.154; 4.G.172.157; 4.G.172.166; 4.G.172.169;
4.G.172.172; 4.G.172.175; 4.G.172.240; 4.G.172.244; 4.G.175.228; 4.G.175.229;
4.G.175.230; 4.G.175.231; 4.G.175.236; 4.G.175.237; 4.G.175.238; 4.G.175.239;
4.G.175.154; 4.G.175.157; 4.G.175.166; 4.G.175.169; 4.G.175.172; 4.G.175.175;
4.G.175.240; 4.G.175.244; 4.G.240.228; 4.G.240.229; 4.G.240.230; 4.G.240.231;
4.G.240.236; 4.G.240.237; 4.G.240.238; 4.G.240.239; 4.G.240.154; 4.G.240.157;
4.G.240.166; 4.G.240.169; 4.G.240.172; 4.G.240.175; 4.G.240.240; 4.G.240.244;
4.G.244.228; 4.G.244.229; 4.G.244.230; 4.G.244.231; 4.G.244.236; 4.G.244.237;
4.G.244.238; 4.G.244.239; 4.G.244.154; 4.G.244.157; 4.G.244.166; 4.G.244.169;
4.G.244.172; 4.G.244.175; 4.G.244.240; 4.G.244.244;

Prodrugs of 4.1 4.1.228.228; 4.1.228.229; 4.1.228.230; 4.1.228.231; 4.1.228.236; 4.1.228.237;
4.1.228.238; 4.1.228.239; 4.1.228.154; 4.1.228.157; 41228.166; 4.1.228.169;
4.1.228.172;
4.1.228.175; 4.1.228.240; 4.1.228.244; 4.1.229.228; 41229.229; 4.1.229.230;
4.1.229.231;
4.1.229.236; 4.1.229.237; 4.1.229.238; 4.1.229.239; 4.1.229.154; 4.1.229.157;
4.I.229.166;
4.1.229.169; 4.1.229.172; 4.1.229.175; 4:1.229.240; 41229.244; 4.1.230.228;
4.1.230.229;
4.1.230.230; 4.1.230.231; 41230.236; 4.1.230.237; 4.1.230.238; 4.1.230.239;
4.1.230.154;
4.1.230.157; 4.1.230.166; 4.1.230.169; 4.1.230.172; 4.1.230.175; 4.1.230.240;
4.1.230.244;
4.1.231.228; 4.1.231.229; 4.1.231.230; 4.1.231.231; 4.1.231.236; 4.1.231.237;
4.1.231.238;
4.1.231.239; 4.1.231.154; 4.1.231.157; 4.1.231.166; 4.1.231.169; 4.1.231.172;
4.1.231.175;
4.1.231.240; 4.1.231.244; 4.1.236.228; 4.1.236.229; 4.1.236.230; 4.1.236.231;
4.1.236.236;
4.1.236.237; 4.1.236.238; 4.1.236.239; 4.1.236.154; 4.1.236.157; 4.1.236.166;
4.1.236.169;
4.1.236.172; 4.1.236.175; 4.1.236.240; 4.1.236.244; 4.1.237.228; 4.1.237.229;
4.1.237.230;
4.1.237.231; 4.1.237.236; 4.1.237.237; 4.1.237.238; 4.1.237.239; 4.1.237.154;
4.1.237.157;
4.1.237.166; 4.1.237.169; 4.1.237.172; 4.1.237.175; 4.1.237.240; 4.1.237.244;
4.1.238.228;
4.1.238.229; 4.1.238.230; 4.1.238.231; 4.1.238.236; 4.1.238.237; 4.1.238.238;
4.1.238.239;
4.1.238.154; 4.1.238.157; 4.1.238.166; 4.1.238.169; 4.1.238.172; 4.1.238.175;
4.1.238.240;
4.1.238.244; 4.1.239.228; 4.1.239.229; 4.1.239.230; 4.1.239.231; 4.1.239.236;
4.1.239.237;

4.1.239.238; 4.1.239.239; 4.1.239.154; 4.1.239.157; 4.1.239.166; 4.1.239.169;
4.1.239.172;
4.1.239.175; 4.1.239.240; 4.1.239.244; 4.1.154.228; 4.1.154.229; 4.1.154.230;
4.1.154.231;
4.1.154.236; 4.1.154.237; 4.1.154.238; 4.1.154.239; 4.1.154.154; 4.1.154.157;
4.1.154.166;
4.1.154.169; 4.1.154.172; 4.1.154.175; 4.1.154.240; 4.1.154.244; 4.1.157.228;
4.1.157.229;
4.1.157.230; 4.1.157.231; 4.1.157.236; 4.1.157.237; 4.1.157.238; 4.1.157.239;
4.1.157.154; .
4.1.157.157; 4.1.157.166; 4.1.157.169; 4.1.157.172; 4.1.157.175; 4.1.157.240;
4.1.157.244;
4.1.166.228; 4.1.166.229; 4.1.166.230; 4.1.166.231; 4.1.166.236; 4.1.166.237;
4.1.166.238;
4.1.166.239; 4.1.166.154; 4.1.166.157; 4.1.166.166; 4.1.166.169; 41166.172;
4.1.166.175;
4.1.166.240; .4.1.166.244; 4.1.169.228; 4.1.169.229; 4.1.169.230; 4.1.169.231;
4.1.169.236;
41169.237; 4.1.169.238; 4.1.169.239; 4.1.169.154; 4.1.169.157; 4.1.169.166;
4.1.169.169;
4.1.169.172; 4.1.169.175; 4.1.169.240; 4.1.169.244; 4.1.172.228; 4.1.172.229;
4_1.172.230;
4.1.172.231; 4.1.172.236; 4.1.172.237; 4.1.172.238; 4.1.172.239; 4.1.172.154;
4.1.172.157;
4.1.172.166; 4.1.172.169; 4.1.172.172; 4.1.172.175; 4.1.172.240; 4.1.172.244;
4.1.175.228;
4.1.175.229; 4.1.175.230; 41175.231; 4.1.175.236; 4.1.175.237; 4.1.175.238;
4.1.175.239;
4.1.175.154; 4.1.175.157; 4.1.175.166; 4.1.175.169; 4.1.175.172; 4.1.175.175;
4.1.175.240;
4.1.175.244; 4.1.240.228; 4.1.240.229; 4.1.240.230; 4.1.240.231; 4.1.240.236;
4.1.240.237;
4.1.240.238; 4.1.240.239; 4.1.240.154; 4.1.240.157; 4.1.240.166; 4.1.240.169;
4.1.240.172;
4.1.240.175; 4.1.240.240; 4.1.240.244; 4.1.244.228; 4.1.244.229; 4.1.244.230;
4.1.244.231;
4.1.244.236; 4.1.244.237; 4.1.244.238; 4.1.244.239; 4.1.244.154; 4.1.244.157;
4.1.244.166;
4.1.244.169; 4.1.244.172; 4.1.244.175; 4.1.244.240; 4.1.244.244;
Prodru s~; of 4.T
4.J.228.228; 4.J.228.229; 4.J.228.230; 4.J.228.231; 4.J.228.236; 4.J.228.237;
4.J.228.238; 4.J.228.239; 4.J.228.154; 4.J.228.157; 4.J.228.166; 4.J.228.169;
4.J.228.172;
4.J.228.175; 4J.228.240; 4.J.228.244; 4.J.229.228; 4.J.229.229; 4.J.229.230;
4.J.229.231;
4.J.229.236; 4.J.229.237; 4.J.229.238; 4.J.229.239; 4.J.229.154; 4.J.229.157;
4.J.229.166;
4.J.229.169; 4.J.229.172; 4.J.229.175; 4.J.229.240; 4.J.229.244; 4.J.230.228;
4.J.230.229;
4.J.230.230; 4.J.230.231; 4.J.230.236; 4.J.230.237; 4.J.230.238; 4.J.230.239;
4.J.230.154;
4.J.230.157; 4.J.230.166; 4.J.230.169; 4.J.230.172; 4.J.230.175; 4.J.230.240;
4.J.230.244;
4.J.231.228; 4.J.231.229; 4.J.231.230; 4.J.231.231; 4.J.231.236; 4.J.231.237;
4.J.231.238;
4.J.231.239; 4.J.231.154; 4.J.231.157; 4.J.231.166; 4.J.231.169; 4.J.231.172;
4.J.231.175;

4.J.231.240; 4.J.231.244; 4.J.236.228; 4.J.236.229; 4.J.236.230; 4.J.236.231;
4.J.236.236;
4.J.236.237; 4.J.236.238; 4.J.236.239; 4.J.236.154; 4.J.236.157; 4.J.236.166;
4.J.236.169;
4.J.236.172; 4.J.236.175; 4.J.236.240; 4.J.236.244; 4.J.237.228; 4.J.237.229;
4.J.237.230;
4.J.237.231; 4.J.237.236; 4.J.237.237; 4.J.237.238; 4.J.237.239; 4.J.237.154;
4.j:237.157;
4.J.237.166; 4.J.237.169; 4.J.237.172; 4.J.237.175; 4.J.237.240; 4.J.237.244;
4.J.238.228;
4.J.238.229; 4.J.238.230; 4.J.238.231; 4.J.238.236; 4.J.238.237; 4.J.238.238;
4.J.238.239;
4.J.238.154; 4.J.238.157; 4.J.238.166; 4.J.238.169; 4.J.238.172; 4.J.238.175;
4.J.238.240;
4.J.238.244; 4.J.239.228; 4.J.239.229; 4.J.239.230; 4.J.239.231; 4.J.239.236;
4.J.239.237;
4.J.239.238; 4.J.239.239; 4.J.239.154; 4.J.239.157; 4.J.239.166; 4.J.239.169;
4.J.239.172;
4.j.239.175; 4.J.239.240; 4.J.239.244; 4.J.154.228; 4.J.154.229; 4.J.154.230;
4.J.154.231;
4.J.154.236; 4.J.154.237; 4.J.154.238; 4.J.154.239; 4.J.154.154; 4.J.154.157;
4.J.154.166;
4.J.154.169; 4.J.154.172; 4.J.154.175; 4.J.154.240; 4.J.154.244; 4.J.157.228;
4.J.157.229;
4.J.157.230; 4.J.157.231; 4.J.157.236; 4.J.157.237; 4.J.157.238; 4.J.157.239;
4.J.157.154;
4.J.157.157; 4.J.157.166; 4.J.157.169; 4.J.157.172; 4.J.157.175; 4.J.157.240;
4.J.157.244;
4.J.166.228; 4.J.166.229; 4.J.166.230; 4.J.166.231; 4.J.166.236; 4.J.166.237;
4.J.166.238;
4.J.166.239; 4.J.166.154; 4.1.166.157; 4.J.166.166; 4.J.166.169; 4.J.166.172;
4.J.166.175;
4.J.166.240; 4.J.166.244; 4.J.169.228; 4.J.169.229; 4.J.169.230; 4.J.169.231;
4.J.169.236;
4.J.169.237; 4.J.169.238; 4.J.169.239; 4.J.169.154; 4.J.169.157; 4.J.169.166;
4.J.169.169;
4.J.169.172; 4.J.169.175; 4.J.169.240; 4.J.169.244; 4.J.172.228; 4.J.172.229;
4.J.172.230;
4.J.172.231; 4.J.172.236; 4.J.172.237; 4.J.172.238; 4.J.172.239; 4.J.172.154;
4.J.172.157;
4.J.172.166; 4.J.172.169; 4.J.172.172; 4.J.172.175; 4.J.172.240; 4.J.172.244;
4.J.175.228;
4.J.175.229; 4.J.175.230; 4.J.175.231; 4.J.175.236; 4.J.175.237; 4.J.175.238;
4.J.175.239;
4.J.175.154; 4.J.175.157; 4.J.175.166; 4.J.175.169; 4.J.175.172; 4.J.175.175;
4.J.175.240;
4.J.175.244; 4.J.240.228; 4.J.240.229; 4.J.240.230; 4.J.240.231; 4.J.240.236;
4.J.240.237;
4.J.240.238; 4.J.240.239; 4.J.240.154; 4.J.240.157; 4.J.240.166; 4.J.240.169;
4.J.240.172;
4.J.240.175; 4.J.240.240; 4.J.240.244; 4.J.244.228; 4.J.244.229; 4.J.244.230;
4.J.244.231;
4.J.244.236; 4.J.244.237; 4.J.244.238; 4.J.244.239; 4.J.244.154; 4.J.244.157;
4.J.244.166;
4.J.244.169; 4.J.244.172; 4.J.244.175; 4.J.244.240; 4.J.244.244;

Prodrugs of 4.L

4.L.228.228; 4.L.228.229; 4.L.228.230; 4.L.228.231; 4.L.228.236; 4.L.228.237;
4.L.228.238; 4.L.228.239; 4.L.228.154; 4.L.228.157; 4.L.228.166; 4.L.228.169;
4.L.228.172; 4.L.228.175; 4.L.228.240; 4.L.228.244; 41.229.228; 4.L.229.229;
4.L.229.230; 4.L.229.231; 4.L.229.236; 4.L.229.237; 41.229.238; 4.L.229.239;
4.L.229.154; 4.L.229.157; 4.L.229.166; 4.L.229.169; 4.L.229.172; 4.L.229.175;
4.L.229.240; 4.L.229.244; 4.L.230.228; 4.L.230.229; 4.L.230.230; 4.L.230.231;
4.L.230.236; 4.L.230.237; 4.L.230.238; 4.L.230.239; 4.L.230.154; 4.L.230.157;
4.L.230.166; 4.L.230.169; 4.L.230.172; 4.L.230.175; 4.L.230.240; 4.L.230.244;
4.L.231.228; 4.L.231.229; 4.L.231.230; 4.L.231.231; 4.L.231.236; 4.L.231.237;
4.L.231.238; 4.L.231.239; 4.L.231.154; 4.L.231.157; 4.L.231.166; 4.L.231.169;
4.L.231.172; 4.L.231.175; 4.L.231.240; 4.L.231.244; 4.L.236.228; 4.L.236.229;
4.L.236.230; 4.L.236.231; 4.L.236.236; 4.L.236.237; 4.L.236.238; 4.L.236.239;
4.L.236.154; 4.L.236.157; 4.L.236.166; 4.L.236.169; 4.L.236.172; 41.236.175;
4.L.236.240; 4.L.236.244; 4.L.237.228; 4.L.237.229; 4.L.237.230; 4.L.237.231;
4.L.237.236; 4.L.237.237; 4.L.237.238; 4.L.237.239; 4.L.237.154; 4.L.237.157;
4.L.237.166; 4.L.237.169; 4.L.237.172; 4.L.237.175; 4.L.237.240; 4.L.237.244;
4.L_238.228; 4.L.238.229; 4.L.238.230; 4.L.238.231; 4.L.238.236; 4.L.238.237;
4.L.238.238; 4.L.238.239; 4.L.238.154; 4.L.238.157; 4.L.238.166; 4.L.238.169;
4.L.238.172; 4.L.238.175; 4.L.238.240; 4.L.238.244; 4.L.239.228; 4.L.239.229;
4.L.239.230; 4.L.239.231; 4.L.239.236; 4.L.239.237; 4.L.239.238; 4.L.239.239;
4.L.239.154; 4.L.239.157; 4.L.239.166; 4.L.239.169; 4.L.239.172; 4.L.239.175;
4.L.239.240; 4.L.239.244; 4.L.154.228; 4.L.154.229; 4.L.154.230; 4.L.154.231;
4.L.154.236; 4.L.154.237; 4.L.154.238; 4.L.154.239; 4.L.154.154; 4.L.154.157;
4.L.154.166; 4.L.154.169; 4.L.154.172; 4.L.154.175; 4.L.154.240; 4.L.154.244;
4.L.157.228; 4.L.157.229; 4.L.157.230; 4.L.157.231; 4.L.157.236; 4.L.157.237;
4.L.157.238; 4.L.157.239; 4.L.157.154; 4.L.157.157; 4.L.157.166; 4.L.157.169;
4.L.157.172; 4.L.157.175; 4.L.157.240; 4.L.157.244; 4.L.166.228; 4.L.166.229;
4.L.166.230; 4.L.166.231; 4.L.166.236; 4.L.166.237; 4.L.166.238; 4.L.166.239;
4.L.166.154; 4.L.166.157; 4.L.166.166; 4.L.166.169; 4.L.166.172; 4.L.166.175;
4.L.166.240; 4.L.166.244; 4.L.169.228; 4.L.169.229; 4.L.169.230; 4.L.169.231;
4.L.169.236; 4.L.169.237; 4.L.169.238; 4.L.169.239; 4.L.169.154; 4.L.169.157;

4.L.169.166; 4.L.169.169; 4.L.169.172; 4.L.169.175; 4.L.169.240; 4.L.169.244;
4.L.172.228; 4.L.172.229; 4.L.172.230; 4.L.172.231; 4.L.172.236; 4.L.172.237;
4.L.172.238; 4.L.172.239; 4.L.172.154; 4.L.172.157; 4.L.172.166; 4.L.172.169;
4.L.172.172; 4.L.172.175; 4.L.172.240; 4.L.172.244; 4.L.175.228; 4.L.175.229;
4.L.175.230; 41.175.231; 4.L.175.236; 4.L.175.237; 4.L.175.238; 4.L.175.239;
4.L.175.154; 4.L.175.157; 4.L.175.166; 4.L.175.169; 4.L.175.172; 4.L.175.175;
4.L.175.240; 4.L.175.244; 4.L.240.228; 4.L.240.229; 4.L.240.230; 4.L.240.231;
4.L.240.236; 4.L.240.237; 4.L.240.238; 41.240.239; 4.L.240.154; 4.L.240.157;
4.L.240.166; 4.L.240.169; 4.L.240.172; 4.L.240.175; 4.L.240.240; 4.L.240.244;
4.L.244.228; 4.L.244.229; 4.L.244.230; 4.L.244.231; 4.L.244.236; 4.L.244.237;
4.L.244.238; 4.L.244.239; 4.L.244.154; 4.L.244.157; 4.L.244.166; 4.L.244.169;
4.L.244.172; 4.L.244.175; 4.L.244.240; 4.L.244.244;

Prodrugs of 4.0 4Ø228.228; 4Ø228.229; 4Ø228.230; 4Ø228.231; 4Ø228.236; 4Ø228.237;
4Ø228.238; 4Ø228.239; 4Ø228.154; 4Ø228.157; 4Ø228.166; 4Ø228.169;
4Ø228.172; 4Ø228.175; 4Ø228.240; 4Ø228.244; 4Ø229.228; 4Ø229.229;
4Ø229.230; 4Ø229.231; 4Ø229.236; 4Ø229.237; 4Ø229.238; 4Ø229.239;
4Ø229.154; 4Ø229.157; 4Ø229.166; 4Ø229.169; 4Ø229.172; 4Ø229.175;
4Ø229.240; 4Ø229.244; 4Ø230.228; 4Ø230.229; 4Ø230.230; 4Ø230.231;
4Ø230.236; 4Ø230.237; 4Ø230.238; 4Ø230.239; 4Ø230.154; 4Ø230.157;
4Ø230.166; 4Ø230.169; 4Ø230.172; 4Ø230.175; 4Ø230.240; 4Ø230.244;
4Ø231.228; 4Ø231.229; 4Ø231.230; 4Ø231.231; 4Ø231:236; 4Ø231.237;
4Ø231.238; 4Ø231.239; 4Ø231.154; 4Ø231.157; 4Ø231.166; 4Ø231.169;
4Ø231.172; 4Ø231.175; 4Ø231.240; 4Ø231.244; 4Ø236.228; 4Ø236.229;
4Ø236.230; 4Ø236.231; 4Ø236.236; 4Ø236.237; 4Ø236.238; 4Ø236.239;
4Ø236.154; 4Ø236.157; 4Ø236.166; 4Ø236.169; 4Ø236.172; 4Ø236.175;
4Ø236.240; 4Ø236.244; 4Ø237.228; 4Ø237.229; 4Ø237.230; 4Ø237.231;
4Ø237.236; 4Ø237.237; 4Ø237.238; 4Ø237.239; 4Ø237.154; 4Ø237.157;
4Ø237.166; 4Ø237.169; 4Ø237.172; 4Ø237.175; 4Ø237.240; 4Ø237.244;
4Ø238.228; 4Ø238.229; 4Ø238.230; 4Ø238.231; 4Ø238.236; 4Ø238.237;

4Ø238.238; 4Ø238.239; 4Ø238.154; 4Ø238.157; 4Ø238.166; 4Ø238.169;
4Ø238.172; 4Ø238.175; 4Ø238.240; 4Ø238.244; 4Ø239.228; 4Ø239.229;
4Ø239.230; 4Ø239.231; 4Ø239.236; 4Ø239.237; 4Ø239.238; 4Ø239.239;
4Ø239.154; 4Ø239.157; 4Ø239.166; 4Ø239.169; 4Ø239.172; 4Ø239.175;
4Ø239.240; 4Ø239.244; 4Ø154.228; 4Ø154.229; 4Ø154.230; 4Ø154.231;
4Ø154.236; 4Ø154.237; 4Ø154.238; 4Ø154.239; 4Ø154.154; 4Ø154.157;
4Ø154.166; 4Ø154.169; 4Ø154.172; 4Ø154.175; 4Ø154.240; 4Ø154.244;
4Ø157.228; 4Ø157.229; 4Ø157.230; 4Ø157.231; 4Ø157.236; 4Ø157.237;
4Ø157.238; 4Ø157.239; 4Ø157.154; 4Ø157.157; 4Ø157.166; 4Ø157.169;
4Ø157.172; 4Ø157.175; 4Ø157.240; 4Ø157.244; 4Ø166.228; 4Ø166.229;
4Ø166.230; 4Ø166.231; 4Ø166.236; 4Ø166.237; 4Ø166.238; 4Ø166.239;
4Ø166.154; 4Ø166.157; 4Ø166.166; 4Ø166.169; 4Ø166.172; 4Ø166.175;
4Ø166.240; 4Ø166.244; 4Ø169.228; 4Ø169.229; 4Ø169.230; 4Ø169.231;
4Ø169.236; 4Ø169.237; 4Ø169.238; 4Ø169.239; 4Ø169.154; 4.0_169.157;
4Ø169.166; 4Ø169.169; 4Ø169.172; 4Ø169.175; 4Ø169.240; 4Ø169.244;
4Ø172.228; 4Ø172.229; 4.0:172.230; 4Ø172.231; 4Ø172.236; 4Ø172.237;
4Ø172.238; 4Ø172.239; 4Ø172.154; 4Ø172.157; 4Ø172.166; 4Ø172.169;
4Ø172.172; 4Ø172.175; 4Ø172.240; 4Ø172.244; 4Ø175.228; 4Ø175.229;
4Ø175.230; 4Ø175.231; 4Ø175.236; 4Ø175.237; 4Ø175.238; 4Ø175.239;
4Ø175.154; 4Ø175.157; 4Ø175.166; 4Ø175.169; 4Ø175.172; 4Ø175.175;
4Ø175.240; 4Ø175.244; 4Ø240.228; 4Ø240.229; 4Ø240.230; 4Ø240.231;
4Ø240.236; 4Ø240.237; 4Ø240.238; 4Ø240.239; 4Ø240.154; 4Ø240.157;
4Ø240.166; 4Ø240.169; 4Ø240.172; 4Ø240.175; 4Ø240.240; 4Ø240.244;
4Ø244.228; 4Ø244.229; 4Ø244.230; 4Ø244.231; 4Ø244.236; 4Ø244.237;
4Ø244.238; 4Ø244.239; 4Ø244.154; 4Ø244.157; 4Ø244.166; 4Ø244.169;
4Ø244.172; 4Ø244.175; 4Ø244.240; 4Ø244.244;

Prodrugs of 4.P
4.P.228.228; 4.P.228.229; 4.P.228.230; 4.P.228.231; 4.P.228.236; 4.P.228.237;
4.P.228.238; 4.P.228.239; 4.P.228.154; 4.P.228.157; 4.P.228.166; 4.P.228.169;
4.P.228.172; 4.P.228.175; 4.P.228.240; 4.P.228:244; 4.P.229.228; 4.P.229.229;

4.P.229.230; 4.P.229.231; 4.P.229.236; 4.P.229.237; 4.P.229.238; 4.P.229.239;
4.P.229.154; 4.P.229.157; 4.P.229.166; 4.P.229.169; 4.P.229.172; 4.P.229.175;
4.P.229.240; 4.P.229.244; 4.P.230.228; 4.P.230.229; 4.P.230.230; 4.P.230.231;
4.P.230.236; 4.P.230.237; 4.P.230.238; 4.P.230.239; 4.P.230.154; 4.P.230.157;
4.P.230.166; 4.P.230.169; 4.P.230.172; 4.P.230.175; 4.P.230.240; 4.P.230.244;
4.P.231.228; 4.P.231.229; 4.P.231.230; 4.P.231.231; 4.P.231.236; 4.P.231.237;
4.P.231.238; 4.P.231.239; 4.P.231.154; 4.P.231.157; 4.P.231.166; 4.P.231.169;
4.P.231.172; 4.P.231.175; 4.P.231.240; 4.P.231.244; 4.P.236.228; 4.P.236.229;
4.P.236.230; 4.P.236.231; 4.P.236.236; 4.P.236.237; 4.P.236.238; 4.P.236.239;
4.P.236.154; 4.P.236.157; 4.P.236.166; 4.P.236.169; 4.P.236.172; 4.P.236.175;
4.P.236.240; 4.P.236.244; 4.P.237.228; 4.P.237.229; 4.P.237.230; 4.P.237.231;
4.P.237.236; 4.P.237.237; 4.P.237.238; 4.P.237.239; 4.P.237.154; 4.P.237.157;
4.P.237.166; 4.P.237.169; 4.P.237.172; 4.P.237.175; 4.P.237.240; 4.P.237.244;
4.P.238.228; 4.P.238.229; 4.P.238.230; 4.P.238.231; 4.P.238.236; 4.P.238.237;
4.P.238.238; 4.P.238.239; 4.P.238.154; 4.P.238.157; 4.P.238.166; 4.P.238.169;
4.P.238.172; 4.P.238.175; 4.P.238.240; 4.P.238.244; 4.P.239.228; 4.P.239.229;
4.P.239.230; 4.P.239.231; 4.P.239.236; 4.P.239.237; 4.P.239.238; 4.P.239.239;
4.P.239.154; 4.P.239.157; 4.P.239.166; 4.P.239.169; 4.P.239.172; 4.P.239.175;
4.P.239.240; 4.P.239.244; 4.P.154.228; 4.P.154.229; 4.P.154.230; 4.P.154.231;
4.P.154.236; 4.P.154.237; 4.P.154.238; 4.P.154.239; 4.P.154.154; 4.P.154.157;
4.P.154.166; 4.P.154.169; 4.P.154.172; 4.P.154.175; 4.P.154.240; 4.P.154.244;
4.P.157.228; 4.P.157.229; 4.P.157.230; 4.P.157.231; 4.P.157.236; 4.P.157.237;
4.P.157.238; 4.P.157.239; 4.P.157.154; 4.P.157.157; 4.P.157.166; 4.P.157.169;
4.P.157.172; 4.P.157.175; 4.P.157.240; 4.P.157.244; 4.P.166.228; 4.P.166.229;
4.P.166.230; 4.P.166.231; 4.P.166.236; 4.P.166.237; 4.P.166.238; 4.P.166.239;
4.P.166.154; 4.P.166.157; 4.P.166.166; 4.P.166.169; 4.P.166.172; 4.P.166.175;
4.P.166.240; 4.P.166.244; 4.P.169.228; 4.P.169.229; 4.P.169.230; 4.P.169.231;
4.P.169.236; 4.P.169.237; 4.P.169.238; 4.P.169.239; 4.P.169.154; 4.P.169.157;
4.P.169.166; 4.P.169.169; 4.P.169.172; 4.P.169.175; 4.P.169.240; 4.P.169.244;
4.P.172.228; 4.P.172.229; 4.P.172.230; 4.P.172.231; 4.P.172.236; 4.P.172.237;
4.P.172.238; 4.P.172.239; 4.P.172.154; 4.P.172.157; 4.P.172.166; 4.P.172.169;

4.P.172.172; 4.P.172.175; 4.P.172.240; 4.P.172.244; 4.P.175.228; 4.P.175.229;
4.P.175.230; 4.P.175.231; 4.P.175.236; 4.P.175.237; 4.P.175.238; 4.P.175.239;
4.P.175.154; 4.P.175.157; 4.P.175.166; 4.P.175.169; 4.P.175.172; 4.P.175.175;
4.P.175.240; 4.P.175.244; 4.P.240.228; 4.P.240.229; 4.P.240.230; 4.P.240.231;
4.P.240.236; 4.P.240.237; 4.P.240.238; 4.P.240.239; 4.P.240.154; 4.P.240.157;
4.P.240.166; 4.P.240.169; 4.P.240.172; 4.P.240.175; 4.1'.240.240; 4.P.240.244;
4.P.244.228; 4.P.244.229; 4.P.244.230; 4.P.244.231; 4.P.244.236; 4.P.244.237;
4.P.244.238; 4.P.244.239; 4.P.244.154; 4.P.244.157; 4.P.244.166; 4.P.244.169;
4.P.244.172; 4.P.244.175; 4.P.244.240; 4.P.244.244;

Prodrugs of 4.U
4.U.228.228; 4.U.228.229; 4.U.228.230; 4.U.228.231; 4.U.228.236; 4.U.228.237;
4.U.228.238; 4.U.228.239; 4.U.228.154; 4.U.228.157; 4.U.228.166; 4.U.228.169;
4.U.228.172; 4.U.228.175; 4.U.228.240; 4.U.228.244; 4.U.229.228; 4.U.229.229;
4.U.229.230; 4.U.229.231; 4.U.229.236; 4.U.229.237; 4.U.229.238; 4.U.229.239;
4.U.229.154; 4.U.229.157; 4.U.229.166; 4.U.229.169; 4.U.229.172; 4.U.229.175;
4.U.229.240; 4.U.229.244; 4.U.230.228; 4.U.230.229; 4.U.230.230; 4.U.230.231;
4.U.230.236; 4.U.230.237; 4.U.230.238; 4.U.230.239; 4.U.230.154; 4.U.230.157;
4.U.230.166; 4.U.230.169; 4.U.230.172; 4.U.230.175; 4.U.230.240; 4.U.230.244;
4.U.231.228; 4.U.231.229; 4.U.231.230; 4.U.231.231; 4.U.231.236; 4.U.231.237;
4.U.231.238; 4.U.231.239; 4.U.231.154; 4.U.231.157; 4.U.231.166; 4.U.231.169;
4.U.231.172; 4.U.231.175; 4.U.231.240; 4.U.231.244; 4.U.236.228; 4.U.236.229;
4.U.236.230; 4.U.236.231; 4.U.236.236; 4.U.236.237; 4.U.236.238; 4.U.236.239;
4.U.236.154; 4.U.236.157; 4.U.236.166; 4.U.236.169; 4.U.236.172; 4.U.236.175;
4.U.236.240; 4.U.236.244; 4.U.237.228; 4.U.237.229; 4.U.237.230; 4.U.237.231;
4.U.237.236; 4.U.237.237; 4.U.237.238; 4.U.237.239; 4.U.237.154; 4.U.237.157;
4.U.237.166; 4.U.237.169; 4.U.237.172; 4.U.237.175; 4.U.237.240; 4.U.237.244;
4.U.238.228; 4.U.238.229; 4.U.238.230; 4.U.238.231; 4.U.238.236; 4.U.238.237;
4.U.238.238; 4.U.238.239; 4.U.238.154; 4.U.238.157; 4.U.238.166; 4.U.238.169;
4.U.238.172; 4.U.238.175; 4.U.238.240; 4.U.238.244; 4.U.239.228; 4.U.239.229;
4.U.239.230; 4.U.239.231; 4.U.239.236; 4.U.239.237; 4.U.239_238; 4.U.239.239;

4.U.239.154; 4.U.239.157; 4.U.239.166; 4.U.239.169; 4.U.239.172; 4.U.239.175;
4.U.239.240; 4.U.239.244; 4.U.154.228; 4.U.154.229; 4.U.154.230; 4.U.154.231;
4.U.154.236; 4.U.154.237; 4.U.154.238; 4.U.154.239; 4.U.154.154; 4.U.154.157;
4.U.154.166; 4.U.154.169; 4.U.154.172; 4.U.154.175; 4.U.154.240; 4.U.154.244;
4.U.157.228; 4.U.157.229; 4.U.157.230; 4.U.157.231; 4.U.157.236; 4.U.157.237;
4.U.157.238; 4.U.157.239; 4.U.157.154; 4.U.157.157; 4.U.157.166; 4.U.157.169;
4.U.157.172; 4.U.157.175; 4.U.157.240; 4.U.157.244; 4.U.166.228; 4.U.166.229;
4.U.166.230; 4.U.166.231; 4.U.166.236; 4.U.166.237; 4.U.166.238; 4.U.166.239;
4.U.166.154; 4.U.166.157; 4.U.166.166; 4.U.166.169; 4.U.166.172; 4.U.166.175;
4.U.166.240; 4.U.166.244; 4.U.169.228; 4.U.169.229; 4.U.169.230; 4.U.169.231;
4.U.169.236; 4.U.169.237; 4.U.169.238; 4.U.169.239; 4.U.169.154; 4.U.169.157;
4.U.169.166; 4.U.169.169; 4.U.169.172; 4.U.169.175; 4.U.169.240; 4.U.169.244;
4.U.172.228; 4.U.172.229; 4.U.172.230; 4.U.172.231; 4.U.172.236; 4.U.172.237;
4.U.172.238; 4.U.172.239; 4.U.172.154; 4.U.172.157; 4.U.172.166; 4.U.172.169;
4.U.172.172; 4.U.172.175; 4.U.172.240; 4.U.172.244; 4.U.175.228; 4.U.175.229;
4.U.175.230; 4_U.175.231; 4.U.175.236; 4.U.175.237; 4.U.175.238; 4.U.175.239;
4.U.175.154; 4.U.175.157; 4.U.175.166; 4.U.175.169; 4.U.175.172; 4.U.175.175;
4.U.175.240; 4.U.175.244; 4.U.240.228; 4.U.240.229; 4.U.240.230; 4.U.240.231;
4.U.240.236; 4.U.240.237; 4.U.240.238; 4.U.240.239; 4.U.240.154; 4.U.240.157;
4.U.240.166; 4.U.240.169; 4.U.240.172; 4.U.240.175; 4.U.240.240; 4.U.240.244;
4.U.244.228; 4.U.244.229; 4.U.244.230; 4.U.244.231; 4.U.244.236; 4.U.244.237;
4.U.244.238; 4.U.244.239; 4.U.244.154; 4.U.244.157; 4.U.244.166; 4.U.244.169;
4.U.244.172; 4.U.244.175; 4.U.244.240; 4.U.244.244;

Prodrugs of 4.W
4.W.228.228; 4.W.228.229; 4.W.228.230; 4.W.228.231; 4.W.228.236; 4.W.228.237;
4.W.228.238; 4.W.228.239; 4.W.228.154; 4.W.228.157; 4.W.228.166; 4.W.228.169;
4.W.228.172; 4.W.228.175; 4.W.228.240; 4.W.228.244; 4.W.229.228; 4.W.229.229;
4.W.229.230; 4.W.229.231; 4.W.229.236; 4.W.229.237; 4.W.229.238; 4.W.229.239;
4.W.229.154; 4.W.229.157; 4.W.229.166; 4.W.229.169; 4.W.229.172; 4.W.229.175;
4.W.229.240; 4.W.229.244; 4.W.230.228; 4.W.230.229; 4.W.230.230; 4.W.230.231;

4.W.230.236; 4.W.230.237; 4.W.230.238; 4.W.230.239; 4.W.230.154; 4.W.230.157;
4.W.230.166; 4.W.230.169; 4.W.230.172; 4.W.230.175; 4.W.230.240; 4.W.230.244;
4.W.231.228; 4.W.231.229; 4.W.231.230; 4.W.231.231; 4.W.231.236; 4.W.231.237;
4.W.231.238; 4.W.231.239; 4.W.231.154; 4.W.231.157; 4.W.231.166; 4.W.231.169;
4.W.231.172; 4.W.231.175; 4.W.231.240; 4.W.231.244; 4.W.236.228; 4.W.236.229;
4.W.236.230; 4.W.236.231; 4.W.236.236; 4.W.236.237; 4.W.236.238; 4.W.236.239;
4.W.236.154; 4.W.236.157; 4.W.236.166; 4.W.236.169; 4.W.236.172; 4.W.236.175;
4.W.236.240; 4.W.236.244; 4.W.237.228; 4.W.237.229; 4.W.237.230; 4.W.237.231;
4.W.237.236; 4.W.237.237; 4.W.237.238; 4.W.237.239; 4.W.237.154; 4.W.237.157;
4.W.237.166; 4.W.237.169; 4.W.237.172; 4.W.237.175; 4.W.237.240; 4.W.237.244;
4.W.238.228; 4.W.238.229; 4.W.238.230; 4.W.238.231; 4.W.238.236; 4.W.238.237;
4.W.238.238; 4.W.238.239; 4.W.238.154; 4.W.238.157; 4.W.238.166; 4.W.238.169;
4.W.238.172; 4.W.238.175; 4.W.238.240; 4.W.238.244; 4.W.239.228; 4.W.239.229;
4.W.239.230; 4.W.239.231; 4.W.239.236; 4.W.239.237; 4.W.239.238; 4.W.239.239;
4.W.239.154; 4.W.239.157; 4.W.239.166; 4.W.239.169; 4.W.239.172; 4.W.239.175;
4.W.239.240; 4.W.239.244; 4.W.154.228; 4.W.154.229; 4.W.154.230; 4.W.154.231;
4.W.154.236; 4.W.154.237; 4.W_154.238; 4.W.154.239; 4.W.154.154; 4.W.154.157;
4.W.154.166; 4.W.154.169; 4.W.154.172; 4.W.154.175; 4.W.154.240; 4.W.154.244;
4.W.157.228; 4.W.157.229; 4.W.157.230; 4.W.157.231; 4.W.157.236; 4.W.157.237;
4.W.157.238; 4.W.157.239; 4.W.157.154; 4.W.157.157; 4.W.157.166; 4.W.157.169;
4.W.157.172; 4.W.157.175; 4.W.157.240; 4.W.157.244; 4.W.166.228; 4.W.166.229;
4.W.166.230; 4.W.166.231; 4.W.166.236; 4.W.166.237; 4.W.166.238; 4.W.166.239;
4.W.166.154; 4.W.166.157; 4.W.166.166; 4.W.166.169; 4.W.166.172; 4.W.166.175;
4.W.166.240; 4.W.166.244; 4.W.169.228; 4.W.169.229; 4.W.169.230; 4.W.169.231;
4.W.169.236; 4.W.169.237; 4.W.169.238; 4.W.169.239; 4.W.169.154; 4.W.169.157;
4.W.169.166; 4.W.169.169; 4.W.169.172; 4.W.169.175; 4.W.169.240; 4.W.169.244;
4.W.172.228; 4.W.172.229; 4.W.172.230; 4.W.172.231; 4.W.172.236; 4.W.172.237;
4.W.172.238; 4.W.172.239; 4.W.172.154; 4.W.172.157; 4.W.172.166; 4.W.172.169;
4.W.172.172; 4.W.172.175; 4.W.172.240; 4.W.172.244; 4.W.175.228; 4.W.175.229;
4.W.175.230; 4.W.175.231; 4.W.175.236; 4.W.175.237; 4.W.175.238; 4.W.175.239;
4.W.175.154; 4.W.175.157; 4.W.175.166; 4.W.175.169; 4.W.175.172; 4.W.175.175;

4.W.175.240; 4.W.175.244; 4.W.240.228; 4.W.240.229; 4.W.240.230; 4.W.240.231;
4.W.240.236; 4.W.240.237; 4.W.240.238; 4.W.240.239; 4.W.240.154; 4.W.240.157;
4.W.240.166; 4.W.240.169; 4.W.240.172; 4.W.240.175; 4.W.240.240; 4.W.240.244;
4.W.244.228; 4.W.244.229; 4.W.244.230; 4.W.244.231; 4.W.244.236; 4.W.244.237;
4.W.244.238; 4.W.244.239; 4.W.244.154; 4.W.244.157; 4.W.244.166; 4.W.244.169;
4.W.244.172; 4.W.244.175; 4.W.244.240; 4.W.244.244;

Prodrugs of 4.Y
4.Y.228.228; 4.Y.228.229; 4.Y.228.230; 4.Y.228.231; 4.Y.228.236; 4.Y.228.237;
4.Y.228.238; 4.Y.228.239; 4.Y.228.154; 4.Y.228.157; 4.Y.228.166; 4.Y.228.169;
4.Y.228.172; 4.Y.228.175; 4.Y.228.240; 4.Y.228.244; 4.Y.229.228; 4.Y.229.229;
4.Y.229.230; 4.Y.229.231; 4.Y.229.236; 4.Y.229.237; 4.Y.229.238; 4.Y.229.239;
4.Y.229.154; 4.Y.229.157; 4.Y.229.166; 4.Y.229.169; 4.Y.229.172; 4.1.229.175;
4.Y.229.240; 4.Y.229.244; 4.Y.230.228; 4.Y.230.229; 4.Y.230.230; 4.Y.230.231;
4.Y.230.236; 4.Y.230.237; 4.Y.230.238; 4.Y.230.239; 4.Y.230.154; 4.Y.230.157;
4.Y.230.166; 4.Y.230.169; 4.Y.230.172; 4.Y.230.175; 4.Y.230.240; 4.Y.230.244;
4.Y.231.228; 4.Y.231.229; 4.Y.231.230; 4.Y.231.231; 4.Y.231.236; 4.Y.231.237;
4.Y.231.238; 4.Y.231.239; 4.Y.231.154; 4.Y.231.157; 4.Y.231.166; 4.Y.231.169;
4.Y.231.172; 4.Y.231.175; 4.Y.231.240; 4.Y.231.244; 4.Y.236.228; 4.1.236.229;
4.Y.236.230; 4.Y.236.231; 4.Y.236.236; 4.Y.236.237; 4.Y.236.238; 4.Y.236.239;
4.Y.236.154; 4.Y.236.157; 4.Y.236.166; 4.Y.236.169; 4.Y.236.172; 4.Y.236.175;
4.Y.236.240; 4.Y.236.244; 4.Y.237.228; 4.Y.237.229; 4.Y.237.230; 4.Y.237.231;
4.Y.237.236; 4.Y.237.237; 4.Y.237.238; 4.Y.237.239; 4.Y.237.154; 4.Y.237.157;
4.Y.237.166; 4.Y.237.169; 4.Y.237.172; 4.Y.237.175; 4.Y.237.240; 4.Y.237.244;
4.Y.238.228; 4.Y.238.229; 4.Y.238.230; 4.Y.238.231; 4.Y.238.236; 4.Y.238.237;
4.Y.238.238; 4.Y.238.239; 4.1.238.154; 4.Y.238.157; 4.Y.238.166; 4.Y.238.169;
4.Y.238.172; 4.Y.238.175; 4.Y.238.240; 4.Y.238.244; 4.Y.239.228; 4.Y.239.229;
4.Y.239.230; 4.Y.239.231; 4.1.239.236; 4.Y.239.237; 4.Y.239.238; 4.Y.239.239;
4.Y.239.154; 4.Y.239.157; 4.Y.239.166; 4.Y.239.169; 4.Y.239.172; 4.Y.239.175;
4.Y.239.240; 4.Y.239.244; 4.Y.154.228; 4.Y.154.229; 4.Y.154.230; 4.Y.154.231;
4.Y.154.236; 4.Y.154.237; 4.Y.154.238; 4.Y.154.239; 4.Y.154.154; 4.Y.154.157;

4.Y.154.166; 4.Y.154.169; 4.Y.154.172; 4.Y.154.175; 4.Y.154.240; 4.Y.154.244;
4.Y.157.228; 4.Y.157.229; 4.Y.157.230; 4.Y.157.231; 4.Y.157.236; 4.Y.157.237;
4.Y.157.238; 4.Y.157.239; 4.Y.157.154; 4.Y.157.157; 4.Y.157.166; 4.Y.157.169;
4.Y.157.172; 4.Y.157.175; 4.Y.157.240; 4.Y.157.244; 4.Y.166.228; 4.Y.166.229;
4.Y.166.230; 4.Y.166.231; 4.Y.166.236; 4.Y.166.237; 4.Y.166.238; 4.Y.166.239;
4.Y.166.154; 4.Y.166.157; 4.Y.166.166; 4.Y.166.169; 4.Y.166.172; 4.Y.166.175;
4.Y.166.240; 4.Y.166.244; 4.Y.169.228; 4.Y.169.229; 4.Y.169.230; 4.Y.169.231;
4.Y.169.236; 4.Y.169.237; 4.Y.169.238; 4.Y.169.239; 4.Y.169.154; 4.Y.169.157;
4.Y.169.166; 4.Y.169.169; 4.Y.169.172; 4.Y.169.175; 4.Y.169.240; 4.Y.169.244;
4.Y.172.228; 4.Y.172.229; 4.Y.172.230; 4.Y.172.231; 4.Y.172.236; 4.Y.172.237;
4.Y.172.238; 4.Y.172.239; 4.Y.172.154; 4.Y.172.157; 4.Y.172.166; 4.Y.172.169;
4.Y.172.172; 4.Y.172.175; 4.Y.172.240; 4.Y.172.244; 4.Y.175.228; 4.Y.175.229;
4.Y.175.230; 4.Y.175.231;.4.Y.175.236; 4.Y.175.237; 4.Y.175.238; 4.Y.175.239;
4.Y.175.154; 4.Y.175.157; 4.Y.175.166; 4.Y.175.169; 4.Y.175.172; 4.Y.175.175;
4.Y.175.240; 4.Y.175.244; 4.Y.240.228; 4.Y.240.229; 4.Y.240.230; 4.Y.240.231;
4.Y.240.236; 4.Y.240.237; 4.Y.240.238; 4.Y.240.239; 4.Y.240.154; 4.Y.240.157;
4.Y.240.166; 4.Y.240.169; 4.Y.240.172; 4.Y.240.175; 4.Y.240.240; 4.Y.240.244;
4.Y.244.228; 4.Y.244.229; 4.Y.244.230; 4.Y.244.231; 4.Y.244.236; 4.Y.244.237;
4.Y.244.238; 4.Y.244.239; 4.Y.244.154; 4.Y.244.157; 4.Y.244.166; 4.Y.244.169;
4.Y.244.172; 4.Y.244.175; 4.Y.244.240; 4.Y.244.244;
Prodrugs of 5.B
5.B.228.228; 5.B.228.229; 5.B.228.230; 5.B.228.231; 5.B.228.236; 5.B.228.237;
5.B.228.238; 5.B.228.239; 5.B.228.154; 5.B.228.157; 5.B.228.166; 5.B.228.169;
5.B.228.172; 5.B.228.175; 5.B.228.240; 5.B.228.244; 5.B.229.228; 5.B.229.229;
5.B.229.230; 5.B.229.231; 5.B.229.236; 5.B.229.237; 5.B.229.238; 5.B.229.239;
5.B.229.154; 5.B.229.157; 5.B.229.166; 5.B.229.169; 5.B.229.172; 5.B.229.175;
5.B.229.240; 5.B.229.244; 5.B.230.228; 5.B.230.229; 5.B.230.230; 5.B.230.231;
5.B.230.236; 5.B.230.237; 5.B.230.238; 5.B.230.239; 5.B.230.154; 5.B.230.157;
5.B.230.166; 5.B.230.169; 5.B.230.172; 5.B.230.175; 5.B.230.240; 5.B.230.244;
5.B.231.228; 5.B.231.229; 5.B.231.230; 5.B.231.231; 5.B.231.236; 5.B.231.237;

5.B.231.238; 5.B.231.239; 5.B.231.154; 5.B.231.157; 5.B.231.166; 5.B.231.169;
5.B.231.172; 5.B.231.175; 5.B.231.240; 5.B.231.244; 5.B.236.228; 5.B.236.229;
5.B.236.230; 5.B.236.231; 5.B.236.236; 5.B.236.237; 5.B.236.238; 5.B.236.239;
5.B.236.154; 5.B.236.157; 5.B.236.166; 5.B.236.169; 5.B.236.172; 5.B.236.175;
5.B.236.240; 5.B.236.244; 5.B.237.228; 5.B.237.229; 5.B.237.230; 5.B.237.231;
5.B.237.236; 5.B.237.237; 5.B.237.238; 5.B.237.239; 5.B.237.154; 5.B.237.157;
5.B.237.166; 5.B.237.169; 5.B.237.172; 5.B.237.175; 5.B.237.240; 5.B.237.244;
5.B.238.228; 5.B.238.229; 5.B.238.230; 5.B.238.231; 5.B.238.236; 5.B.238.237;
5.B.238.238; 5.B.238.239; 5.B.238.154; 5.B.238.157; 5.B.238.166; 5.B.238.169;
5.B.238.172; 5.B.238.175; 5.B.238.240; 5:B.238.244; 5.B.239.228; 5.B.239.229;
5.B.239.230; 5.B.239.231; 5.B.239.236; 5.B.239.237; 5.B.239.238; 5.B.239.239;
5.B.239.154; 5.B.239.157; 5.B.239.166; 5.B.239.169; 5.B.239.172; 5.B.239.175;
5.B.239.240; 5.B.239.244; 5.B.154.228; 5.B.154.229; 5.B.154.230; 5.B.154.231;
5.B.154.236; 5.B.154.237; 5.B.154.238; 5.B.154.239; 5.B.154.154; 5.B.154.157;
5.B.154.166; 5.B.154.169; 5.B.154.172; 5.B.154.175; 5.B.154.240; 5.B.154.244;
5.B.157.228; 5.B.157.229; 5.B.157.230; 5.B.157.231; 5.B.157.236; 5.B.157.237;
5.B.157.238; 5.B.157.239; 5.B.157.154; 5.B.157.157; 5.B.157.166; 5.B.157.169;
5.B.157.172; 5.B.157.175; 5.B.157.240; 5.B.157.244; 5.B.166.228; 5.B.166.229;
5.B.166.230; 5.B.166.231; 5.B.166.236; 5.B.166.237; 5.B.166.238; 5.B.166.239;
53.166.154; 5.B.166.157; 5.B.166.166; 5.B.166.169; 5.B.166.172; 5.B.166.175;
5.B.166.240; 5.B.166.244; 5.B.169.228; 5.B.169.229; 5.B.169.230; 5.B.169.231;
5.B.169.236; 5.B.169.237; 5.B.169.238; 5.B.169.239; 5.B.169.154; 5.B.169.157;
5.B.169.166; 5.B.169.169; 5.B.169.172; 5.B.169.175; 5.B.169.240; 5.B.169.244;
5.B.172.228; 5.B.172.229; 5.B.172.230; 5.B.172.231; 5.B.172.236; 5.B.172.237;
5.B.172.238; 5.B.172.239; 5.B.172.154; 5.B.172.157; 5.B.172.166; 5.B.172.169;
5.B.172.172; 5.B.172.175; 5.B.172.240; 5.B.172.244; 5.B.175.228; 5.B.175.229;
5.B.175.230; 5.B.175.231; 5.B.175.236; 5.B.175.237; 5.B.175.238; 5.B.175.239;
5.B.175.154; 5.B.175.157; 5.B.175.166; 5.B.175.169; 5.B.175.172; 5.B.175.175;
5.B.175.240; 5.B.175.244; 5.B.240.228; 5.B.240.229; 5.B.240.230; 5.B.240.231;
5.B.240.236; 5.B.240.237; 5.B.240.238; 5.B.240.239; 5.B.240.154; 5.B.240.157;
5.B.240.166; 5.B.240.169; 5.B.240.172; 5.B.240.175; 5.B.240.240; 5.B.240.244;

5.B.244.228; 5.B.244.229; 5.B.244.230; 5.B.244.231; 5.B.244.236; 5.B.244.237;
5.B.244.238; 5.B.244.239;.5.B.244.154; 5.B.244.157; 5.B.244.166; 5.B.244.169;
5.B.244.172; 5.B.244.175; 5.B.244.240; 5.B.244.244;

Prodrugs of 5.D
5.D.228.228; 5.D.228.229; 5.D.228.230; 5.D.228.231; 5.D.228.236; 5.D.228.237;
5.D.228.238; 5.D.228.239; 5.D.228.154; 5.D.228.157; 5.D.228.166; 5.D.228.169;
5.D.228.172; 5.D.228.175; 5.D.228.240; 5.D.228.244; 5.D.229.228; 5.D.229.229;
511229.230; 5.D.229.231; 5.D.229.236; 5.D.229.237; 5.D.229.238; 5.D.229.239;
511229.154; 5.D.229.157; 5.D.229.166; 5.D.229.169; 5.D.229.172; 5.D.229.175;
5.D.229.240; 5.D.229.244; 5.D.230.228; 5.D.230.229; 5.D.230.230; 5.D.230.231;
5.D.230.236; 5.D.230.237; 5.D.230.238; 5.D.230.239; 5.D.230.154; 5.D.230.157;
5.D.230.166; 5.D.230.169; 5.D.230.172; 5.D.230.175; 5.D.230.240; 5.D.230.244;
5.D.231.228; 5.D.231.229; 5.D.231.230; 5.D.231.231; 5.D.231.236; 5.D.231.237;
5.D.231.238; 5.D.231.239; 5.D.231.154; 5.D.231.157; 5.D.231.166; 5.D.231.169;
5.D.231.172; 5.D.231.175; 5.D.231.240; 511231.244; 5.D.236.228; 5.D.236.229;
5.D.236.230; 5.D.236.231; 5.D.236.236; 5.D.236.237; 5.D.236.238; 5.D.236.239;
5.D.236.154; 5.D.236.157; 5.D.236.166; 5.D.236.169; 5.D.236.172; 5.D.236.175;
5.D.236.240; 5.D.236.244; 5.D.237.228; 5.D.237.229; 5.D.237.230; 5.D.237.231;
5.D.237.236; 5.D.237.237; 5.D.237.238; 5.D.237.239; 5.D.237.154; 5.D.237.157;
5.D.237.166; 5.D.237.169; 5.D.237.172; 5.D.237.175; 5.D.237.240; 5.D.237.244;
5.D.238.228; 5.D.238.229; 5.D.238.230; 5.D.238.231; 5.D.238.236; 5.D.238.237;
5.D.238.238; 5.D.238.239; 5.D.238.154; 5.D.238.157; 511238.166; 5.D.238.169;
5.D.238.172; 5.D.238.175; 5.D.238.240; 5.D.238.244; 5.D.239.228; 5.D.239.229;
5.D.239.230; 5.D.239.231; 5.D.239.236; 5.D.239.237; 5.D.239.238; 5.D.239.239;
5.D.239.154; 5.D.239.157; 5.D.239.166; 5.D.239.169; 5.D.239.172; 5.D.239.175;
5.D.239.240; 5.D.239.244; 5.D.154.228; 5.D.154.229; 5.D.154.230; 5.D.154.231;
5.D.154.236; 5.D.154.237; 5.D.154.238; 5.D.154.239; 5.D.154.154; 5.D.154.157;
5.D.154.166; 5.D.154.169; 5.D.154.172; 5.D.154.175; 5.D.154.240; 5.D.154.244;
5.D.157.228; 5.D.157.229; 5.D.157.230; 5.D.157.231; 5.D.157.236; 5.D.157.237;
5.D.157.238; 5.D.157.239; 5.D.157.154; 5.D.157.157; 5.D.157.166; 5.D.157.169;

5.D.157.172; 5.D.157.175; 5.D.157.240; 5.D.157.244; 5.D.166.228; 5.D.166.229;
5.D.166.230; 5.D.166.231; 5.D.166.236; 5.D.166.237; 5.D.166.238; 5.D.166.239;
5.D.166.154; 5.D.166.157; 5.D.166.166; 5.D.166.169; 5.D.166.172; 5.D.166.175;
5.D.166.240; 5.D.166.244; 5.D.169.228; 5.D.169.229; 5.D.169.230; 5.D.169.231;
5.D.169.236; 5.D.169.237; 5.D.169.238; 5.D.169.239; 5.D.169.154; 5.D.169.157;
5.D.169.166; 5.D.169.169; 5.D.169.172; 5.D.169.175; 5.D.169.240; 5.D.169.244;
5.D.172.228; 5.D.172.229; 5.D.172.230; 5.D.172.231; 5.D.172.236; 5.D.172.237;
5.D.172.238; 5.D.172.239; 5.D.172.154; 5.D.172.157; 5.D.172.166; 5.D.172.169;
5.D.172.172; 5.11172.175; 5.D.172.240; 5.D.172.244; 5.D.175.228; 5.D.175.229;
5.D.175.230; 5.D.175.231; 5.D.175.236; 5.D.175.237; 5.D.175.238; 5.D.175.239;
5.D.175.154; 5.D.175.157; 5.D.175.166; 5.D.175.169; 5.D.175.172; 5.D.175.175;
5.D.175.240; 5.D.175.244; 5.D.240.228; 5.D.240.229; 5.D.240.230; 5.D.240.231;
5.D.240.236; 5.D.240.237; 5.D.240.238; 5.D.240.239; 5.D.240.154; 5.D.240.157;
5.D.240.166; 5.D.240.169; 5.D.240.172; 5.D.240.175; 5.D.240.240; 5.D.240.244;
5.D.244.228; 5.D.244.229; 5.D.244.230; 5.D.244.231; 5.D.244.236; 5.D.244.237;
5.D.244.238; 5.D.244.239; 5.D.244.154; 5.D.244.157; 5.D.244.166; 5.D.244.169;
5.D.244.172; 5.D.244.175; 5.D.244.240; 5.D.244.244;

Prodrugs of 5.E
5.E.228.228; 5.E.228.229; 5.E.228.230; 5.E.228.231; 5.E.228.236; 5.E.228.237;
5.E.228.238; 5.E.228.239; 5.E.228.154; 5.E.228.157; 5.E.228.166; 5.E.228.169;
5.E.228.172; 5.E.228.175; 5.E.228.240; 5.E.228.244; 5.E.229.228; 5.E.229.229;
5.E.229.230; 5.E.229.231; 5.E.229.236; 5.E.229.237;. 5.E.229.238; 5.E.229.239;
5.E.229.154; 5.E.229.157; 5.E.229.166; 5.E.229.169; 5.E.229.172; 5.E.229.175;
5.E.229.240; 5.E.229.244; 5.E.230.228; 5.E.230.229; 5.E.230.230; 5.E.230.231;
5.E.230.236; 5.E.230.237; 5.E.230.238; 5.E.230.239; 5.E.230.154; 5.E.230.157;
5.E.230.166; 5.E.230.169; 5.E.230.172; 5.E.230.175; 5.E.230.240; 5.E.230.244;
5.E.231.228; 5.E.231.229; 5.E.231.230; 5.E.231.231; 5.E.231.236; 5.E.231.237;
5.E.231.238; 5.E.231.239; 5.E.231.154; 5.E.231.157; 5.E.231.166; 5.E.231.169;
5.E.231.172; 5.E.231.175; 5.E.231.240; 5.E.231.244; 5.E.236.228; 5.E.236.229;
5.E.236.230; 5.E.236.231; 5.E.236.236; 5.E.236.237; 5.E.236.238; 5.E.236.239;

5.E.236.154; 5.E.236.157; 5.E.236.166; 5.E.236.169; 5.E.236.172; 5.E.236.175;
5.E.236.240; 5.E.236.244; 5.E.237.228; 5.E.237.229; 5.E.237.230; 5.E.237.231;
5.E.237.236; 5.E.237.237; 5.E.237.238; 5.E.237.239; 5.E.237.154; 5.E.237.157;
5.E.237.166; 5.E.237.169; 5.E.237.172; 5.E.237.175; 5.E.237.240; 5.E.237.244;
5.E.238.228; 5.E.238.229; 5.E.238.230; 5.E.238.231; 5.E.238.236; 5.E.238.237;
5.E.238.238; 5.E_238.239; 5.E.238.154; 5.E.238.157; 5.E.238.166; 5.E.238.169;
5.E.238.172; 5.E.238.175; 5.E.238.240; 5.E.238.244; 5.E.239.228; 5.E.239.229;
5.E.239.230; 5.E.239.231; 5.E.239.236; 5.E.239.237; 5.E.239.238; 5.E.239.239;
5.E.239.154; 5.E.239.157; 5.E.239.166; 5.E.239.169; 5.E.239.172; 5.E.239.175;
5.E.239.240; 5.E.239.244; 5.E.154.228; 5.E.154.229; 5.E.154.230; 5.E.154.231;
5.E.154.236; 5.E.154.237; 5.E.154.238; 5.E.154.239; 5.E.154.154; 5.E.154.157;
5.E.154.166; 5.E.154.169; 5.E.154.172; 5.E.154.175; 5.E.154.240; 5.E.154.244;
5.E.157.228; 5.E.157.229; 5.E.157.230; 5.E.157.231; 5.E.157.236; 5.E.157.237;
5.E.157.238; 5.E.157.239; 5.E.157.154; 5.E.157.157; 5.E.157.166; 5.E.157.169;
5.E.157.172; 5.E.157.175; 5.E.157.240; 5.E.157.244; 5.E.166.228; 5.E.166.229;
5.E.166.230; 5.E.166.231; 5.E.166.236; 5.E.166.237; 5.E.166.238; 5.E.166.239;
5.E.166.154; 5.E.166.157; 5.E.166.166; 5.E.166.169; 5.E.166.172; 5.E.166.175;
5.E.166.240; 5.E.166.244; 5.E.169.228; 5.E.169.229; 5.E.169.230; 5.E.169.231;
5.E.169.236; 5.E.169.237; 5.E.169.238; 5.E.169.239; 5.E.169.154; 5.E.169.157;
5.E.169.166; 5.E.169.169; 5.E.169.172; 5.E.169.175; 5.E.169.240; 5.E.169.244;
5.E.172.228; 5.E.172.229; 5.E.172.230; 5.E.172.231; 5.E.172.236; 5.E.172.237;
5.E.172.238; 5.E.172.239; 5.E.172.154; 5.E.172.157; 5.E.172.166; 5.E.172.169;
5.E.172.172; 5.E.172.175; 5.E.172.240; 5.E.172.244; 5.E.175.228; 5.E.175.229;
5.E.175.230; 5.E.175.231; 5.E.175.236; 5.E.175.237; 5.E.175.238; 5.E.175.239;
5.E.175.154; 5.E.175.157; 5.E.175.166; 5.E.175.169; 5.E.175.172; 5.E.175.175;
5.E.175.240; 5.E.175.244; 5.E.240.228; 5.E.240.229; 5.E.240.230; 5.E.240.231;
5.E.240.236; 5.E.240.237; 5.E.240.238; 5.E.240.239; 5.E.240.154; 5.E.240.157;
5.E.240.166; 5.E.240.169; 5.E.240.172; 5.E.240.175; 5.E.240.240; 5.E.240.244;
5.E.244.228; 5.E.244.229; 5.E.244.230; 5.E.244.231; 5.E.244.236; 5.E.244.237;
5.E.244.238; 5.E.244.239; 5.E.244.154; 5.E.244.157; 5.E.244.166; 5.E.244.169;
5.E.244.172; 5.E.244.175; 5.E.244.240; 5.E.244.244;

Prodrugs of 5.G
5.G.228.228; 5.G.228.229; 5.G.228.230; 5.G.228.231; 5.G.228.236; 5.G.228.237;
5.G.228.238; 5.G.228.239; 5.G.228.154; 5.G.228.157; 5.G.228.166; 5.G.228.169;
5.G.228.172; 5.G.228.175; 5.G.228.240; 5.G.228.244; 5.G.229.228; 5.G.229.229;
5.G.229.230; 5.G.229.231; 5.G.229.236; 5.G.229.237; 5.G.229.238; 5.G.229.239;
5.G.229.154; 5.G.229.157; 5.G.229.166; 5.G.229.169; 5.G.229.172; 5.G.229.175;
5.G.229.240; 5.G.229.244; 5.G.230.228; 5.G.230.229; 5.G.230.230; 5.G.230.231;
5.G.230.236; 5.G.230.237; 5.G.230.238; 5.G.230.239; 5.G.230.154; 5.G.230.157;
5.G.230.166; 5.G.230.169; 5.G.230.172; 5.G.230.175; 5.G.230.240; 5.G.230.244;
5.G.231.228; 5.G.231.229; 5.G.231.230; 5.G.231.231; 5.G.231.236; 5.G.231.237;
5.G.231.238; 5.G.231.239; 5.G.231.154; 5.G.231.157; 5.G.231.166; 5.G.231.169;
5.G.231.172; 5.G.231.175; 5.G.231.240; 5.G_231.244; 5.G.236.228; 5.G;236.229;
5.G.236.230; 5.G.236.231; 5.G.236.236; 5.G.236.237; 5.G.236.238; 5.G.236.239;
5.G.236.154; 5.G.236.157; 5.G.236.166; 5.G.236.169; 5.G.236.172; 5.G.236.175;
5.G.236.240; 5.G.236.244; 5.G.237.228; 5.G.237.229; 5.G.237.230; 5.G.237.231;
5.G.237.236; 5.G.237.237; 5.G.237.238; 5.G.237.239; 5.G.237.154; 5.G.237.157;
5.G.237.166; 5.G.237.169; 5.G.237.172; 5.G.237.175; 5.G.237.240; 5.G.237.244;
5.G.238.228; 5.G.238.229; '5.G.238.230; 5.G.238.231; 5.G.238.236; 5.G.238.237;
5.G.238.238; 5.G.238.239; 5.G.238.154; 5.G.238.157; 5.G.238.166; 5.G.238.169;
5.G.238.172; 5.G.238.175; 5.G.238.240; 5.G.238.244; 5.G.239.228; 5.G.239.229;
5.G.239.230; 5.G.239.231; 5.G.239.236; 5.G.239.237; 5.G.239.238; 5.G.239.239;
5.G.239.154; 5.G.239.157; 5.G.239.166; 5.G.239.169; 5.G.239.172; 5.G.239.175;
5.G.239.240; 5.G.239.244; 5.G.154.228; 5.G.154.229; 5.G.154.230; 5.G.154.231;
5.G.154.236; 5.G.154.237; 5.G.154.238; 5.G.154.239; 5.G.154.154; 5.G.154.157;
5.G.154.166; 5.G.154.169; 5.G.154.172; 5.G.154.175; 5.G.154.240; 5.G.154.244;
5.G.157.228; 5.G.157.229; 5.G.157.230; 5.G.157.231; 5.G.157.236; 5.G.157.237;
5.G.157.238; 5.G.157.239; 5.G.157.154; 5.G.157.157; 5.G.157.166; 5.G.157.169;
5.G.157.172; 5.G.157.175; 5.G.157.240; 5.G.157.244; 5.G.166.228; 5.G.166.229;
5.G.166.230; 5.G.166.231; 5.G.166.236; 5.G.166.237; 5.G.166.238; 5.G.166.239;
5.G.166.154; 5.G.166.157; 5.G.166.166; 5.G.166.169; 5.G.166.172; 5.G.166.175;

5.G.166.240; 5.G.166.244; 5.G.169.228; 5.G.169.229; 5.G.169.230; 5.G.169.231;
5.G.169.236; 5.G.169.237; 5.G.169.238; 5.G.169.239; 5.G.169.154; 5.G.169.157;
5.G.169.166; 5.G.169.169; 5.G.169.172; 5.G.169.175; 5.G.169.240; 5.G.169.244;
5.G.172.228; 5.G.172.229; 5.G.172.230; 5.G.172.231; 5.G.172.236; 5.G.172.237;
5.G.172.238; 5.G.172.239; 5.G.172.154; 5.G.172.157; 5.G.172.166; 5.G.172.169;
5.G.172.172; 5.G.172.175; 5.G.172.240; 5.G.172.244; 5.G.175.228; 5.G.175.229;
5.G.175.230; 5.G.175.231; 5.G.175.236; 5.G.175.237; 5.G.175.238; 5.G.175.239;
5.G.175.154; 5.G.175.157; 5.G.175.166; 5.G.175.169; 5.G.175.172; 5.G.175.175;
5.G.175.240; 5.G.175.244; 5.G.240.228; 5.G.240.229; 5.G.240.230; 5.G.240.231;
5.G.240.236; 5.G.240.237; 5.G.240.238; 5.G.240.239; 5.G.240.154; 5.G.240.157;
5.G.240.166; 5.G.240.169; 5.G.240.172; 5.G.240.175; 5.G.240.240; 5.G.240.244;
5.G.244.228; 5.G.244.229; 5.G.244.230; 5.G.244.231; 5.G.244.236; 5.G.244.237;
5.G.244.238; 5.G.244.239; 5.G.244.154; 5.G.244.157; 5.G.244.166; 5.G.244.169;
5.G.244.172; 5.G.244.175; 5.G.244.240; 5.G.244.244;

Prodru s~ of 5.1 5.1.228.228; 5.1.228.229; 5.1.228.230; 5.1.228.231; 5.1.228.236; 5.1.228.237;
5.1.228.238; 5.1.228.239; 5.1.228.154; 5.1.228.157; 5.1.228.166; 5.1.228.169;
5.1.228.172;
5.1.228.175; 5.1.228.240; 5.1.228.244; 5.I.229.228; 5.1.229.229; 5.1.229.230;
5.1.229.231;
5.1.229.236; 5.1.229.237; 5.1.229.238; 5.1.229.239; 5.1.229.154; 5.1.229.157;
5.1.229.166;
5.1.229.169; 5.1.229.172; 5.1.229.175; 5.1.229.240; 5.1.229.244; 5.1.230.228;
5.1.230.229;
5.1.230.230; 5.1.230.231; 5.1.230.236; 5.1.230.237; 5.1.230.238; 5.1.230.239;
5.1.230.154;
5.1.230.157; 5.1.230.166; 5.1.230.169; 5.1.230.172; 5.1.230.175; 5.1.230.240;
5.1.230.244;
5.1.231.228; 5.1.231.229; 5.1.231.230; 5.1.231.231; 51231.236; 51.231.237;
5.1.231.238;
5.1.231.239; 5.1.231.154; 5.1.231.157; 5.1.231.166; 5.1.231.169; 5.1.231.172;
5:1.231.175;
5.1.231.240; 5.1.231.244; 5.1.236.228; 5.1.236.229; 5.1.236.230; 5.1.236.231;
5.1.236.236;
51236.237; 5.1.236.238; 5.1.236.239; 5.1.236.154; 5.1.236.157; 5.1.236.166;
5.1.236.169;
5.1.236.172; 5.1.236.175; 5.1.236.240; 5.1.236.244; 5.1.237.228; 5.1.237.229;
5.1.237.230;
5.1.237.231; 5.1.237.236; 5.1.237.237; 5.1.237.238; 5.1.237.239; 5.1.237.154;
5.1.237.157;
5.1.237.166; 5.1.237.169; 5.1.237.172; 5.1.237.175; 5.1.237.240; 5.1.237.244;
5.1.238.228;
5.1.238.229; 5.1.238.230; 5.1.238.231; 5.1.238.236; 5.1.238.237; 5.1.238.238;
5.1.238.239;

5.1.238.154; 5.1.238.157; 5.1.238.166; 5.1.238.169; 5.1.238.172; 5.1.238.175;
5.1.238.240;
5.1.238.244; 5.1.239.228; 5.1.239.229; 5.1.239.230; 5.1.239.231; 5.1.239.236;
5.1.239.237;
5.1.239.238; 5.1.239.239; 5.1.239.154; 5.1.239.157; 5.1.239.166; 5.1.239.169;
5.1.239.172;
5.1.239.175; 5.1.239.240; 51239.244; 5.1.154.228; 5.1.154.229; 5.1.154.230;
5.1.154.231;
5.1.154.236; 5.1.154.237; 5.1.154.238; 5.1.154.239; 5.1.154.154; 5.1.154.157;
5.1.154.166;
5.1.154.169; 5.1.154.172; 51154.175; 5.1.154.240; 5.1.154.244; 51157.228;
5.1.157.229;
5.1.157.230; 5.1.157.231; 5.1.157.236; 5.1.157.237; 5.1.157.238; 5.1.157.239;
5.1.157.154;
5.1.157.157; 5.1.157.166; 5.1.157.169; 5.1.157.172; 5.1.157.175; 5.1.157.240;
5.1.157.244;
5.1.166.228; 5.1.166.229; 5.1.166.230; 5.1.166.231; 5.1.166.236; 5.1.166.237;
5.1.166.238;
51166.239; 5.1.166.154; 5.1.166.157; 5.1.166.166; 5.1.166.169; 5.1.166.172;
5.1.166.175;
5.1.166.240; 5.1.166.244; 5.1.169.228; 5.1.169.229; 5.1.169.230; 5.1.169.231;
5.1.169.236;
5.1.169.237; 51169.238; 5.1.169.239; 5.1.169.154; 5.1.169.157; 5.1.169.166;
5.1.169.169;
5.1.169.172; 5.1.169.175; 5.1.169.240; 5.1.169.244; 5.1.172.228; 5.1.172.229;
5.1.172.230;
5.1.172.231; 5.1.172.236; 5.1.172.237; 5.1.172.238; 5.1.172.239; 5.1.172.154;
5.1.172.157;
5.1.172.166; 5.1.172.169; 5.1.172.172; 5.1.172.175; 5.1.172.240; 5.1.172.244;
5.1.175.228;
5.1.175.229; 5.1.175.230; 51175.231; 5.1.175.236; 5.1.175.237; 5.1.175.238;
5.1.175.239;
5.1.175.154; 5.1.175.157; 5.1.175.166; 5.1.175.169; 5.1.175.172; 5.1.175.175;
5.1.175.240;
5.1.175.244; 5.1.240.228; 5.1.240.229; 5.1.240.230; 5.1.240.231; 5.1.240.236;
5.1.240.237;
5.1.240.238; 5.1.240.239; 5.1.240.154; 5.1.240.157; 5.1.240.166; 5.1.240.169;
5.1.240.172;
5.1.240.175; 5.1.240.240; 5.1.240.244; 5.1.244.228; 5.1.244.229; 5.1.244.230;
5.1.244.231;
5.1.244.236; 5.1.244.237; 5.1.244.238; 5.1.244.239; 5.1.244.154; 5.1.244.157;
5.1.244.166;
5.1.244.169; 5.1.244.172; 5.1.244.175; 5.1.244.240; 5.1.244.244;

Prodrugs of 5.1 . 5.J.228.228; 5.J.228.229; 5.J.228.230; 5.J.228.231; 5.J.228.236;
5.J.228.237;
5.J.228.238; 5.J.228.239; 5.J.228.154; 5.J.228.157; 5.J.228.166; 5.J.228.169;
5.J.228.172;
5.J.228.175; 5.J.228.240; 5.J.228.244; 5.J.229.228; 5.J.229.229; 5.J.229.230;
5.J.229.231;
5.J.229.236; 5.J.229.237; 5.J.229.238; 5.J.229.239; 5.J.229.154; 5.J.229.157;
5.J.229.166;
5.J.229.169; 5.J.229.172; 5.J.229.175; 5.J.229.240; 5.J.229.244; 5.J.230.228;
5.J.230.229;
5.J.230.230; 5.J.230.231; 5.J.230.236; 5.J.230.237; 5.J.230.238; 5.J.230.239;
5.J.230.154;
5.J.230.157; 5.J.230.166; 5.J.230.169; 5.J.230.172; 5.J.230.175; 5.J.230.240;
5.J.230.244;

5.J.231.228; 5.J.231.229; 5.J.231.230; 5.J.231.231; 5.J.231.236; 5.J.231.237;
5.J.231.238;
5.J.231.239; 5.J.231.154; 5.J.231.157; 5.J.231.166; 5.J.231.169; 5.J.231.172;
5.J.231.175;
5.J.231.240; 5.J.231.244; 5.J.236.228; 5.J.236.229; 5.J.236.230; 5.J.236.231;
5.J.236.236;
5.J.236.237; 5.J.236.238; 5.J.236.239; 5.J.236.154; 5.J.236.157; 5.J.236.166;
5.J.236.169;
5.J.236.172; 5.J.236.175; 5.J.236.240; 5.J.236.244; 5.J.237.228; 5.J.237.229;
5.J.237.230;
5.J.237.231; 5.J.237.236; 5.J.237.237; 5.J.237.238; 5.J.237.239; 5.J.237.154;
5.J.237.157;
5.J.237.166; 5.J.237.169; 5.J.237.172; 5.J.237.175; 5.J.237.240; 5.J.237.244;
5.J.238.228;
5.J.238.229; 5.J.238.230; 5.J.238.231; 5.J.238.236; 5.J.238.237; 5.J.238.238;
5.J.238.239;
5.J.238.154; 5.J.238.157; 5.J.238.166; 5.J.238.169; 5.J.238.172; 5.J.238.175;
5.J.238.240;
5.J.238.244; 5.J.239.228; 5.J.239.229; 5.J.239.230; 5.J.239.231; 5.J.239.236;
5.J.239.237;
5.J.239.238; 5.J.239.239; 5.J.239.154; 5.J.239.157; 5.J.239.166; 5.J.239.169;
5.J.239.172;
5.J.239.175; 5.J.239.240; 5.J.239.244; 5.J.154.228; 5.J.154.229; 5.J.154.230;
5.J.154.231;
5.J.154.236; 5.J.154.237; 5.J.154.238; 5.J.154.239; 5.J.154.154; 5.J.154.157;
5.J.154.166;
5.J.154.169; 5.J.154.172; 5.J.154.175; 5.J.154.240; 5.J.154.244; 5.J.157.228;
5.J.157.229;
5.J.157.230; 5.J.157.231; 5.J.157.236; 5.J.157.237; 5.J.157.238; 5.J.157.239;
5.J.157.154;
5.J.157.157; 5.J.157.166; 5.J.157.169; 5.J.157.172; 5.J.157.175; 5.J.157.240;
5.J.157.244;
5.J.166.228; 5.J.166.229; 5.J.166.230; 5.J.166.231; 5.J.166.236; 5.J.166.237;
5.J.166.238;
5.J.166.239; 5.J.166.154; 5.J.166.157; 5.J.166.166; 5.J.166.169; 5.J.166.172;
5.J.166.175;
5.J.166.240; 5.J.166.244; 5.J.169.228; 5.J.169.229; 5.J.169.230; 5.J.169.231;
5.J.169.236;
5.J.169.237; 5.J.169.238; 5.J.169.239; 5.J.169.154; 5.J.169.157; 5.J.169.166;
5.J.169.169;
5.J.169.172; 5.J.169.175; 5.J.169.240; 5.J.169.244; 5.J.172.228; 5.J.172.229;
5.J.172.230;
5.J.172.231; 5.J.172.236; 5.J.172.237; 5.J.172.238; 5.J.172.239; 5.J.172.154;
5.J.172.157;
5.J.172.166; 5.J.172.169; 5.J.172.172; 5.J.172.175; 5.J.172.240; 5.J.172.244;
5.J.175.228;
5.J.175.229; 5.J.175.230; 5.J.175.231; 5.J.175.236; 5.J.175.237; 5.J.175.238;
5.J.175.239;
5.J.175.154; 5.J.175.157; 5.J.175.166; 5.J.175.169; 5.J.175.172; 5.J.175.175;
5.J.175.240;
5.J.175.244; 5.J.240.228; 5.J.240.229; 5.J.240.230; 5.J.240.231; 5.J.240.236;
5.J.240.237;
5.J.240.238; 5.J.240.239; 5.J.240.154; 5.J.240.157; 5.J.240.166; 5.J.240.169;
5.J.240.172;
5.J.240.175; 5.J.240.240; 5.J.240.244; 5.J.244.228; 5.J.244.229; 5.J.244.230;
5.J.244.231;
5.J.244.236; 5.J.244.237; 5.J.244.238; 5.J.244.239; 5.J.244.154; 5.J.244.157;
5.J.244.166;
5.J.244.169; 5.J.244.172; 5.J.244.175; 5.J.244.240; 5.J.244.244;

Prodrugs of 5.L
5.L.228.228; 5.L.228.229; 5.L.228.230; 5.L.228.231; 5.L.228.236; 5.L.228.237;
5.L.228.238; 5.L.228.239; 5.L.228.154; 5.L.228.157; 5.L.228.166; 5.L.228.169;
5.L.228.172; 5.L.228.175; 5.L.228.240; 5.L.228.244; 5.L.229.228; 5.L.229.229;
5.L.229.230; 5.L.229.231; 5.L.229.236; 5.L.229.237;-5.L.229.238; 5.L.229.239;
5.L.229.154; 5.L.229.157; 5.L.229.166; 5.L.229.169; 5.L.229.172; 5.L.229.175;
5.L.229.240; 5.L.229.244; 5.L.230.228; 5.L.230.229; 5.L.230.230; 5.L.230.231;
5.L.230.236; 5.L.230.237; 5.L.230.238; 5.L.230.239; 5.L.230.154; 5.L.230.157;
5.L.230.166; 5.L.230.169; 5.L.230.172; 5.L.230.175; 5.L.230.240; 5.L.230.244;
5.L.231.228; 5.L.231.229; 5.L.231.230; 5.L.231.231; 5.L.231.236; 5.L.231.237;
5.L.231.238; 5.L.231.239; 5.L.231.154; 5.L.231.157; 5.L.231.166; 5.L.231.169;
5.L.231.172; 5.L.231.175; 5.L.231.240; 5.L.231.244; 5.L.236.228; 5.L.236.229;
5.L.236.230; 5.L.236.231; 5.L.236.236; 5.L.236.237; 5.L.236.238; 5.L.236.239;
5.L.236.154; 5.L.236.157; 5.L.236.166; 5.L.236.169; 5.L.236.172; 5.L.236.175;
5.L.236.240; 5.L.236.244; 5.L.237.228; 5.L.237.229; 5.1.237.230; 5.L.237.231;
5.L.237.236; 5.L.237.237; 5.L.237.238; 5.L.237.239; 5.L.237.154; 5.L.237.157;
5.L.237.166; 5.L.237.169; 5.L.237.172; 5.L.237.175; 5.L.237.240; 5.L.237.244;
5.L.238.228; 5.L.238.229; 5.L.238.230; 5.L.238.231; 5.L.238.236; 5.L.238.237;
5.L.238.238; 5.L.238.239; 5.L.238.154; 5.L.238.157; 5.L.238.166; 5.L.238.169;
5.L.238.172; 5.L.238.175; 5.L.238.240; 5.L.238.244; 5.L.239.228; 5.L.239.229;
5.L.239.230; 5.L.239.231; 5.L.239.236; 5.L.239.237; 5.L.239.238; 5.L.239.239;
5.L.239.154; 5.L.239.157; 5.L.239.166; 5.L.239.169; 5.L.239.172; 5.L.239.175;
5.L.239.240; 5.L.239.244; 5.L.154.228; 5.L.154.229; 5.L.154.230; 5.L.154.231;
5.L.154.236; 5.L.154.237; 51.154.238; 5.L.154.239; 5.L.154.154; 5.L.154.157;
5.L.154.166; 5.L.154.169; 5.L.154.172; 5.L.154.175; 5.L.154.240; 5.L.154.244;
5.L.157.228; 5.L.157.229; 5.L.157.230; 5.L.157.231; 5.L.157.236; 5.L.157.237;
5.L.157.238; 5.L.157.239; 5.L.157.154; 5.L.157.157; 5.L.157.166; 5.L.157.169;
5.L.157.172; 5.L.157.175; 5.L.157.240; 5.L.157.244; 5.L.166.228; 5.L.166.229;
5.L.166.230; 5.L.166.231; 5.L.166.236; 5.L.166.237; 5.L.166.238; 5.L.166.239;
5.L.166.154; 5.L.166.157; 5.L.166.166; 5.L.166.169; 5.L.166.172; 5.L.166.175;
5.L.166.240; 5.L.166.244; 5.L.169.228; 5.L.169.229; 5.L.169.230; 5.L.169.231;

DEMANDE OU BREVET VOLUMINEUX

LA PRESENTE PARTIE DE CETTE DEMANDE OU CE BREVET COMPREND
PLUS D'UN TOME.

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Claims (67)

1. A compound of Formula I

or a pharmaceutically acceptable salt, solvate, and/or ester thereof, wherein, X is H, alkyl, substituted alkyl, -C(O)-, -S(O)Z , or -S(O)-;
n is 0 when X is H, alkyl, or substituted alkyl;
n is 1 when X is -C(O)-, -S(O)2, or -S(O)-;
L1 and L3 are alkylene;
L2 and L4 are independently selected from the group consisting of a covalent bond, -O-, -NH-, -O-alkylene-, and alkylene;
Ar1, Ar2, Ar3, and Ar4 are independently aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein said substituted aryl or said substituted heteroaryl of Ar1, Ar2, Ar3 and Ar4 is independently substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, haloalkyl, halo, nitro, cyano, hydroxy, amino, alkoxy, haloalkoxy, -NH-alkyl, -NH-(alkyl)2, -NH-acyl, -N(alkyl)-acyl, -NR a-S(O)2- R b, -C(O)-R c, -S(O)2R b, -S(O)2NHR a, -C(O)-NH-R a, -NR a C(O)OR b, -NR a S(O)2NR a R b, -C(O)OR a, and -Z1-alkylene-R7;
R a is H, alkyl, or substituted alkyl;
R b is alkyl, aryl, or substituted aryl;
R7 is aryl, heterocyclyl, substituted aryl, substituted heterocyclyl, -Z2-L5-R7b, or -O-PO3R7c R7d;
L5 is -C(O)-, -C(O)O-, -C(O)NR7e-, -S(O2)-, -S(O)-, -S(O2)NR7e-, or -S(O)NR7e-;

Z1 and Z2 are independently O or NR;
R7a, R7 c, R 7d, and R 7e are independently H, alkyl, or substituted alkyl;
R7b is alkyl, substituted alkyl, heterocyclyl, or substituted heterocyclyl;
p and q are independently 0 or 1;
R1 is -NR1a R1b, -OR1c, -C(R1d R1e)-NR1f-L6-R1g, aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
R1a is H, alkyl, or substituted alkyl;
R1b and R1c are independently selected from alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, arylalkyl, substituted arylalkyl, heterocyclyl alkyl, and substituted heterocyclyl alkyl, wherein said substituted arylalkyl is substituted on the aryl moiety and said substituted heterocyclyl alkyl is substituted on the heterocyclyl moiety;
R1d and R1e are independently selected from the group consisting of H, alkyl, and substituted alkyl; or R1d and R1e taken together with the carbon atom to which they are attached form a cycloalkyl, a substituted cycloalkyl, a non-aromatic heterocyclyl, or a substituted non-aromatic heterocyclyl;
L6 is -C(O)-, -C(O)-O-, or -C(O)-NR1h-, -S(O)2-, -S(O)2-O-, -S(O)2 NR1b -, -S(O)-, -S(O)-O-, or -S(O)-NR1b -;
R1f and R1b are independently H, alkyl, or substituted alkyl;
R1g is alkyl or substituted alkyl;
R2, R4, and R5 are each independently selected from the group consisting of H, alkyl, and substituted alkyl;
R3 is selected from the group consisting of H, -CH2-OC(O)-R3a, -CH2-OC(O)O-R3a, -CH2-O-PO3 -2, -PO3 -2, and -PO3CH2CF3-1;
R3a is H, alkyl, or substituted alkyl;
R6 is selected from the group consisting of -OR 6a, -NR6b R6b,-C(R6d R6e)R6f, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, and substituted heterocyclyl;
R6a and R6b are independently selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, arylalkyl, substituted arylalkyl, heterocyclyl alkyl, substituted heterocyclyl alkyl, wherein said substituted arylalkyl is substituted on the aryl moiety and said substituted heterocyclyl alkyl is substituted on the heterocyclyl moiety;
R6c is H, alkyl, or substituted alkyl;
R6d and R6e are independently selected from the group consisting of H, alkyl, and substituted alkyl; or R6d and R6e taken together with the carbon atom to which they are attached form a cycloalkyl, a substituted cycloalkyl, a non-aromatic heterocyclyl, or a substituted non-aromatic heterocyclyl;
R6f is selected from the group consisting of heterocyclyl, substituted heterocyclyl, -Z3-aryl, -Z3-(substituted aryl), -Z3-heteroaryl, -Z3-(substituted heteroaryl), -Z3-L7 -R6f2, and -Z3-L8-R6f3;
Z3 is O or NR6f1;
L7 is selected from the group consisting of -C(O)-, -C(O)-O-, and -C(O)-NR6f1-;
L8 is selected from the group consisting of -S(O2)- or -S(O)-, -S(O2)-O-, and -S(O)-O-;
R6f1 is H, alkyl, or substituted alkyl;
R6f2 is alkyl, substituted alkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, wherein said substituted arylalkyl is substituted on the aryl moiety and said substituted heteroarylalkyl is substituted on the heteroaryl moiety; and R6f3 is alkyl,-substituted alkyl, -O-alkyl, -O-(substituted alkyl), -NH-alkyl, -N(alkyl)2, -NH-(substituted alkyl), or -N(substituted alkyl)2; and with the following provisos:
(1) when X is -C(O)- and n is 1, then R1 and R6 are not both -CH(R c)-NH-C(O)-O-R d, wherein R c is -C(CH3)3, -CH(CH3)2, or -CH(CH3)CH2CH3 and R d is -CH3 or -CH2CH3;
(2) when p and q are both 0, then Ar1 and Ar3 are not both phenyl or both fluorophenyl;

(3) when p and q are both 0; and Ar3 is phenyl; then Ar1 is not fluorophenyl, cyanophenyl, methoxyphenyl, hydroxyphenyl, tolyl, trifluoromethylphenyl, trimethoxyphenyl, or thienyl; and (4) when p and q are both 0; Ar3 is phenyl; and R1 is OR1c`; then R1c is not aryl methylene or heterocyclyl methylene.
2. The compound of claim 1, wherein X is -C(O)-, -S(O)2 , or -S(O)-; and R3 is H, alkyl, or substituted alkyl.
3. The compound of claim 2, wherein X is -C(O)- or -S(O)2 ; and R3 is H.
4. The compound of claim 1, wherein R2 is H.
5. The compound of claim 1, wherein R1 is OR1c; and R1c is alkyl, substituted alkyl, heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said substituted heterocyclyl alkyl is substituted on the heterocyclyl moiety, and said heterocyclyl is selected from the group consisting of:
(i) a mono-cyclic 5- or 6-membered aromatic, nonaromatic dihydro, or nonaromatic tetrahydro heterocyclic ring having from 1 to 4 heteroatoms selected from N, O, and S; and (ii) a bi-cyclic 8-, 9-, or 10-membered aromatic, nonaromatic dihydro, or nonaromatic tetrahydro heterocyclic ring having from 1 to 6 heteroatoms selected from N, O, and S.
6. The compound of claim 5, wherein R1c is methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, or tert-butyl.
7. The compound of claim 5, wherein R1c is selected from the group consisting of A1, A2, A3, and A4 are independently NR9 or O;
R8 is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, -O-(alkyl), or -O-(substituted alkyl);

R9 is H, alkyl, or substituted alkyl;
m is 1 or 2; and a and b are independently 0, 1, or 2.
8. The compound of claim 7, wherein A1, A2, A3, and A4 are O, and m is 1.
9. The compound of claim 5, wherein R1c is a heterocyclyl having one of the following structures:

wherein D1, D2, D3, D4, and D5 are independently selected from the group consisting of C, N, O, and S;
n is 0 or 1;
each R12 is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R12), r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent; and is a single or double bond.
10. The compound of claim 1, wherein R1 is R1d and R1e are each independently selected from the group consisting of H, alkyl, and substituted alkyl; or R1d and R1e taken together with the carbon atom to which they are shown attached form a heterocyclyl or a substituted heterocyclyl, wherein said heterocyclyl or said substituted heterocyclyl is a 5- or 6- membered non-aromatic tetrahydro heterocyclic ring having from 1 to 3 heteroatoms selected from N, O, and S, R1f is H, alkyl, or substituted alkyl; and R1g is alkyl or substituted alkyl.
11. The compound of claim 1, wherein R1 is a 5- or 6- membered aryl, 5- or 6-membered substituted aryl, 5- or 6- membered heteroaryl, 5- or 6- membered substituted heteroaryl, 8- to 10- membered bi-cyclic heteroaryl, or 8- to 10-membered bi-cyclic substituted heteroaryl, wherein the substituted aryl or substituted heteroaryl is independently substituted with one or more substituents selected from the group consisting of alkyl, substituted alkyl, hydroxy, -O-alkyl, and -O-(substituted alkyl).
12. The compound of claim 1, wherein R5 is H.
13. The compound of claim 1, wherein q is 0, L3 is alkylene; Ar3 is aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein said substituted aryl or said substituted heteroaryl of Ar3 is substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, hydroxy, alkoxy, and -O-alkylene-R7;

R7 is aryl, heterocyclyl, substituted aryl, substituted heterocyclyl, -NR7a-L5-R7b, or -O-PO3R7c R7d;
L5 is -C(O)-, -C(O)O-, -C(O)NR7e-, -S(O)2 , -S(O)-, -S(O)2NR7e-, or -S(O)NR7e-;
R7a, R7c, R7d, and R7e are independently H, alkyl, or substituted alkyl; and R7b is alkyl or substituted alkyl.
14. The compound of claim 13, wherein q is 0; -L3-Ar3 is R13 is H, alkyl, substituted alkyl, hydroxy, alkoxy; or R13 is one of the following structures:

wherein:
A1 is NR14 or O;
R14 is H, alkyl, or substituted alkyl;
R10 is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, alkoxyalkyl, or substituted alkoxyalkyl;
m is 1 or 2;
p is 0, 1, or 2;
L5 is -C(O)-, -C(O)-O-, or -S(O)2-;
R7b is alkyl, substituted alkyl, heteroaryl, or substituted heteroaryl;
d is 1, 2, 3, or 4; and R7c and R7d are independently alkyl or substituted alkyl.
15. The compound of claim 1, wherein R4 is H.
16. The compound of claim 1, wherein p is 1; L1 is alkylene; L2 is a covalent bond; Ar1 is aryl or substituted aryl; Ar3 is heteroaryl or substituted heteroaryl;
wherein said substituted aryl or said substituted heteroaryl is substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, haloalkyl, halo, nitro, cyano, hydroxy, amino, alkoxy, haloalkoxy, -NH-alkyl, -NH-(alkyl)2, -NH-acyl, and -N(alkyl)-acyl.
17. The compound of claim 16, wherein p is 1; L1 is alkylene;
-Ar1-L2-Ar2 is R11 is H, alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, alkoxyalkyl, or substituted alkoxyalkyl;
d is 1, 2, 3, or 4;
Q is a heterocyclyl having one of the following structures:
D1, D2, D3, D4, and D5 are independently selected from the group consisting of C, N, O, and S;
j is CR12 or N;

each R12 is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R12)r, r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent; and ~ is a single or double bond.
18. The compound of claim 1, wherein p is 1; L1 is alkylene;
Ar1-L2-Ar2 is D1, D2, D3, and D4 are independently selected from the group consisting of C, N, O, and S;
each R12 is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R12)r, r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent; and R11 is H, alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, alkoxyalkyl, or substituted alkoxyalkyl;
d is 1, 2,3, or 4;
m is 1 or 2; and ~ is a single or double bond.
19. The compound of claim 17, wherein p is 1; L1 is alkylene;
Ar1-L2-Ar2 is D1, D2, D3, and D4 are independently selected from the group consisting of C, N, O, and S; and each R12 is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R12)r, r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent.
20. The compound of claim 1, wherein p is 0; L1 is alkylene; Ar1 is aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
wherein said substituted aryl or said substituted heteroaryl is substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, hydroxy, alkoxy, and -O-alkylene-R7;
R7 is aryl, heterocyclyl, substituted aryl, substituted heterocyclyl, -NR7a-L5-R7b, or -O-PO3R7c R7d;
L5 is -C(O)-, -C(O)O-, -C(O)NR7e-, -S(O)2-, -S(O)-, -S(O)2NR7e-, or -S(O)NR7e-;
R7a, R7c, R7d, and R7e are independently H, alkyl, or substituted alkyl; and R7b is alkyl or substituted alkyl.
21. The compound of claim 1, wherein p is 0; q is 1; L1 and L3 are independently alkylene; L4 is a covalent bond;
Ar1, Ar3, and Ar4 are independently aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
wherein said substituted aryl or said substituted heteroaryl is substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, haloalkyl, hydroxy, alkoxy, and -O-alkylene-R7;

R7 is aryl, heterocyclyl, substituted aryl, substituted heterocyclyl, -NR7a-L5-R7b, or -O-PO3R7c R7d;
L5 is -C(O)-, -C(O)O-, -C(O)NR7e-, -S(O)2-, -S(O)-, -S(O)2NR7e-, or -S(O)NR7e-;
R7a, R7c, R7c, and R7e are independently H, alkyl, or substituted alkyl; and is alkyl or substituted alkyl;
22. The compound of claim 1, wherein p and q are both 0; L1 and L3 are independently alkylene;
Ar1 and Ar3 are independently aryl or substituted aryl, wherein said substituted aryl is substituted by one or more substituents selected from the group consisting of alkoxy, haloalkoxy, -O-alkylene-R7; and R7 is aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
with the proviso that Ar1 and Ar3 are not both phenyl.
23. The compound of claim 1, wherein R6 is OR6a, R6a is alkyl or selected from the group consisting of A5 is NR14 or O;
A6, A7, and A8 are independently CR14R15, NR14, or O, with the proviso that at least one of A6 and A7 is NR14, or O;
R10 and R11 are independently H, alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, alkoxyalkyl, or substituted alkoxyalkyl;
R14 and R15 are independently H, alkyl, or substituted alkyl;
a and b are independently 0, 1, or 2;
m is 1 or 2;
D1, D2, D3, D4, and D5 are independently selected from the group consisting of C, N, O, and S;
each R12 is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R12)r, r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent; and ~ is a single or double bond.
24. The compound of claim 1, wherein R6 is selected from the group consisting of R6d and R6e are independently selected from the group consisting of H, alkyl, and substituted alkyl;

R11 is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, alkoxyalkyl, or substituted alkoxyalkyl;
A9 is CR14R15, NR14, or O;
J is CR14R15 or N, with the proviso that A9 and J are not both CR14R15;
R14 and R15 are independently H, alkyl, or substituted alkyl;
A10 and A11 are independently CR14 R15, NR14, S, or O, with the proviso that A10 and A11 are not both CR14 R15;
each R14 and R15 is independently H, alkyl, or substituted alkyl;
m is 1 or 2; and a is 0, 1, or 2.
25. The compound of claim 1, wherein R6 is selected from a group consisting of R6d and R6e are independently selected from the group consisting of H, alkyl, and substituted alkyl;
R11 is H, alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, alkoxyalkyl, or substituted alkoxyalkyl;
d is 1, 2,3, or 4;
D1, D2, D3, D4, and D5 are independently selected from the group consisting of C, N, O, and S;

each R12 is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R12)r, r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent; and ~ is a single or double bond.
26. The compound of claim 1, wherein R6 is R6d and R6e are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy;
or R6d and R6e are taken together to form a 5- or 6- membered non-aromatic tetrahydro heterocyclic ring;
Z is -NR14 or -O-;
R14 is H, alkyl, or substituted alkyl;
R6f1 is H, alkyl, or substituted alkyl; and R6f2 is alkyl, haloalkyl, hydroxyalkyl, or alkoxy.
27. The compound of claim 1, wherein R6 is R6d and R6e are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy;
or R6d and R6e are taken together to form a 5- or 6- membered non-aromatic tetrahydro heterocyclic ring;

Z is -NR14- or -O-;
R14 is H, alkyl, or substituted alkyl;
R6f1 is H, alkyl, or substituted alkyl;
R6f2 is D1, D2, D3, D4, and D5 are independently selected from the group consisting of C, N, O, and S;
each R12 is independently H, alkyl, or substituted alkyl, with the proviso that in each occurrence of (R12)r, r is 0, 1, or 2, whereby carbon is tetravalent, nitrogen is trivalent, and sulfur and oxygen are divalent; and ~ is a single or double bond.
28. The compound of claim 1, wherein R6 is R7d and R7e are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy;
R7f1 is H, alkyl, or substituted alkyl; and R7f2 is alkyl, haloalkyl, hydroxyalkyl, or alkoxy.
29. The compound of claim 1, wherein R6 is R6d and R6e are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy;
R6f1 is H, alkyl, or substituted alkyl; and R6f3 is alkyl, substituted alkyl.
30. The compound of claim 1, wherein X is S(O)2 or S(O); and R7 is alkyl, substituted alkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, wherein said heterocyclyl is selected from the group consisting of:
(i) a 5-membered aromatic, nonaromatic dihydro, or nonaromatic tetrahydro heterocyclic ring having from 1 to 4 heteroatoms selected from N, O, and S; and (ii) a 6-membered aromatic, nonaromatic dihydro, or nonaromatic tetrahydro heterocyclic ring having from 1 to 4 heteroatoms selected from N, O, and S.
31. The compound of claim 30, wherein X is S(O)2; and R7 is methyl, ethyl, n-propyl, 2-propyl, n-butyl, 2-butyl, tert-butyl, and 2,2-dimethylpropyl.
32. The compound of claim 1, wherein X is C(O); p is 1; q is 0; L1 and L3 are alkylene, L2 is a covalent bond;
R1 is -C(R1d R1c)-NR1f-L6-R1g;
R1d is alkyl; R1e is H; R1f is H; -L6-R1g is -C(O)-O-alkyl;
R6 is -C(R6d R6e)R6f;
R6d is alkyl; R6is H; R 61 is -NH-C(O)-O-alkyl;
Ar3 is -aryl-Z1-alkylene-O-PO3R7c R7d; and Z1 is O or NR7a; R7a, R7c, and R7d are independently H, alkyl, or substituted alkyl.
33. The compound of claim 1, wherein X is C(O); p is 1; q is 0; L1 and L3 are alkylene; L2 is a covalent bond;
R1 is -C(R1d R1e)-NR1f~L6 -R1g;
R1d is hydroxyalkyl; R1e is H; R1f is H; -L6-R1g is -C(O)-O-alkyl;
R6 is -C(R6d R6e)R6f; and R6d is hydroxyalkyl; R6e is H; R6f is -NH-C(O)-O-alkyl.
34. The compound of claim 1, wherein X is C(O); p and q are 0; L1 and L3 are alkylene;
Ar3 and Ar1 are independently aryl or substituted aryl, wherein the substituted aryl contains one or more substituents selected from the group consisting of alkoxy, haloalkoxy, -O-alkylene-heterocyclyl, and -O-alkylene-(substituted heterocyclyl).
35. The compound of claim 1, wherein X is C(O); p is 0; q is 1; L1 and L3 are alkylene; and L4 is a covalent bond.
36. The compound of claim 35, wherein Ar1, Ar3, and Ar4 are independently aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein said substituted aryl or said substituted heteroaryl of Ar1, Ar3 and Ar4 are each independently substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, haloalkyl, halo, hydroxy, amino, alkoxy, haloalkoxy.
37. The compound of claim 35, wherein R1 is OR1c; and R1c is alkyl, substituted alkyl, heterocyclyl, substituted heterocyclyl, heterocyclyl alkyl, or substituted heterocyclyl alkyl, wherein said substituted heterocyclyl alkyl is substituted on the heterocyclyl moiety, and said heterocyclyl is selected from the group consisting of:
(i) a mono-cyclic 5- or 6-membered aromatic, nonaromatic dihydro, or nonaromatic tetrahydro heterocyclic ring having from 1 to 4 heteroatoms selected from N, O, and S; and (ii) a bi-cyclic 8-, 9-, or 10-membered aromatic, nonaromatic dihydro, or nonaromatic tetrahydro heterocyclic ring having from 1 to 6 heteroatoms selected from N, O, and S.
38. The compound of claim 37, wherein R1 is OR1c; and R1c is selected from the group consisting of A1, A2, A3, and A4 are independently NR9 or O;
R8 is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, -O-(alkyl), or -O-(substituted alkyl);

R9 is H, alkyl, or substituted alkyl;
m is 1 or 2; and a and b are independently 0, 1, or 2.
39. The compound of claim 35, wherein R6 is R6d and R6e are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy;
or R64 and R* are taken together to form a 5- or 6- membered non-aromatic tetrahydro heterocyclic ring;
Z is -NR14, or -O-;
R14 is H, alkyl, or substituted alkyl;
R6f1 is H, alkyl, or substituted alkyl; and R6f2 is alkyl, haloalkyl, hydroxyalkyl, or alkoxy.
40. The compound of claim 35, wherein R1 is OR1c; and R1c is selected from the group consisting of A1, A2, A3, and A4 are independently NR9 or O;
R8 is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, -O-(alkyl), or -O-(substituted alkyl);

R9 is H, alkyl, or substituted alkyl;
m is 1 or 2;
a and b are independently 0, 1, or 2;
R6 is R6d and R6e are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy;
or R6d and R6e are taken together to form a 5- or 6- membered non-aromatic tetrahydro heterocyclic ring;
Z is -NR14, or -O-;
R14 is H, alkyl, or substituted alkyl;
R6f1 is H, alkyl, or substituted alkyl; and R6f2 is alkyl, haloalkyl, hydroxyalkyl, or alkoxy.
41. The compound of claim 1, wherein X is C(O); p is 1; q is 0; L1 and L3 are alkylene; L2 is a covalent bond;
R1 is OR1c; and R1c is selected from the group consisting of A1, A2, A3, and A4 are independently NR9 or O;
R8 is alkyl, substituted alkyl, haloalkyl, substituted haloalkyl, hydroxyalkyl, substituted hydroxyalkyl, -O-(alkyl), or -O-(substituted alkyl);

R9 is H, alkyl, or substituted alkyl;

m is 1 or 2;
a and b are independently 0, 1, or 2;
R6 is R6d and R6e are independently H, alkyl, haloalkyl, hydroxyalkyl, or alkoxy;
or e and R6e are taken together to form a 5- or 6- membered non-aromatic tetrahydro heterocyclic ring;

Z is -NR14, or -O-;
R14 is H, alkyl, or substituted alkyl;
R6f is H, alkyl, or substituted alkyl; and R6f2 is alkyl, haloalkyl, hydroxyalkyl, or alkoxy.
42. The compound of claim 41, wherein Ar1, Ar2, and Ar4 are independently aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein said substituted aryl or said substituted heteroaryl of Ar1, Ar2 and Ar4 are each independently substituted by one or more substituents selected from the group consisting of alkyl, substituted alkyl, haloalkyl, halo, hydroxy, amino, alkoxy, haloalkoxy.
43. The compound of claim 1, selected from the group consisting of:

and or a pharmaceutically acceptable salt, solvate, and/or ester thereof.
44. A pharmaceutical composition comprising:

a therapeutically effective amount of at least one compound of claim 1, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, and a pharmaceutically acceptable carrier or exipient.
45. The pharmaceutical composition of claim 44, further comprising:
at least one additional active agent.
46. The pharmaceutical composition of claim 45, wherein:
said at least one additional active agent is selected from the group consisting of:
HIV protease inhibiting compounds, HIV non-nucleoside inhibitors of reverse transcriptase, HIV nucleoside inhibitors of reverse transcriptase, HIV
nucleotide inhibitors of reverse transcriptase, HIV integrase inhibitors, gp4l inhibitors, CXCR4 inhibitors, entry inhibitors, gp120 inhibitors, G6PD and NADH-oxidase inhibitors, CCR5 inhibitors, other drugs for treating HIV, and mixtures thereof.
47. The pharmaceutical composition of claim 46, wherein:
(1) said HIV protease inhibitors are selected from the group consisting of amprenavir, atazanavir, fosamprenavir, indinavir, lopinavir, ritonavir, nelfinavir, saquinavir, tipranavir, brecanavir, darunavir, TMC-126, TMC-114, mozenavir (DMP-450), JE-2147 (AG1776), L-756423, RO0334649, KNI-272, DPC-681, DPC-684, GW640385X, DG17, PPL-100, DG35, and AG 1859;
(2) said HIV non-nucleoside inhibitors of reverse transcriptase are selected from the group consisting of capravirine, emivirine, delaviridine, efavirenz, nevirapine, (+) calanolide A, etravirine, GW5634, DPC-083, DPC-961, DPC-963, MIV-150, TMC-120, TMC-278 (rilpivirene), efavirenz, BILR 355 BS, VRX 840773, UK-453061, and RDEA806;
(3) said HIV nucleoside inhibitors of reverse transcriptase are selected from the group consisting of zidovudine, emtricitabine, didanosine, stavudine, zalcitabine, lamivudine, abacavir, amdoxovir, elvucitabine, alovudine, MIV-210, racivir (~-FTC), D-d4FC, emtricitabine, phosphazide, fozivudine tidoxil, apricitibine (AVX754), GS-7340, amdoxovir, KP-1461, and fosalvudine tidoxil (formerly HDP 99.0003);
(4) said HIV nucleotide inhibitors of reverse transcriptase are selected from the group consisting of tenofovir and adefovir;
(5) said HIV integrase inhibitors are selected from the group consisting of curcumin, derivatives of curcumin, chicoric acid, derivatives of chicoric acid, 3,5-dicaffeoylquinic acid, derivatives of 3,5-dicaffeoylquinic acid, aurintricarboxylic acid, derivatives of aurintricarboxylic acid, caffeic acid phenethyl ester, derivatives of caffeic acid phenethyl ester, tyrphostin, derivatives of tyrphostin, quercetin, derivatives of quercetin, S-1360, zintevir (AR-177), elvitegravir, L-870812, and L-870810, MK-0518 (raltegravir), BMS-538158, GSK364735C, BMS-707035, MK-2048, and BA 011;
(6) said gp4l inhibitor are selected from the group consisting of enfuvirtide, sifuvirtide, FB006M, and TRI-1144;
(7) said CXCR4 inhibitor is AMD-070;
(8) said entry inhibitor is SP01A;
(9) said gp120 inhibitor is BMS-488043 or BlockAide/ CR;
(10) said G6PD and NADH-oxidase inhibitor is immunitin;
(11) said CCR5 inhibitors are selected from the group consisting of aplaviroc, vicriviroc, maraviroc, PRO-140, INCB15050, PF-232798 (Pfizer), and CCR5mAb004; and (12) said other drugs for treating HIV are selected from the group consisting of BAS-100, SPI-452, REP 9, SP-01A, TNX-355, DES6, ODN-93, ODN-112, VGV-1, PA-457 (bevirimat), Ampligen, HRG214, Cytolin, VGX-410, KD-247, AMZ 0026, CYT 99007A-221 HIV, DEBIO-025, BAY 50-4798, MDX010 (ipilimumab), PBS 119, ALG 889, and PA-1050040 (PA-040).
48. A combination pharmaceutical agent comprising:
a) a first pharmaceutical composition comprising at least one compound of claim 1, or a pharmaceutically acceptable salt, solvate, and/or ester thereof; and b) a second pharmaceutical composition comprising at least one additional active agent selected from the group consisting of HIV protease inhibiting compounds, HIV non-nucleoside inhibitors of reverse transcriptase, HIV nucleoside inhibitors of reverse transcriptase, HIV nucleotide inhibitors of reverse transcriptase, HIV integrase inhibitors, gp4l inhibitors, CXCR4 inhibitors, entry inhibitors, gp120 inhibitors, G6PD and NADH-oxidase inhibitors, CCR5 inhibitors, other drugs for treating HIV, and mixtures thereof.
49. A method of inhibiting HIV protease in a cell, comprising:
contacting the cell with an amount of at least one compound of claim 1, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, sufficient to inhibit HIV protease in the cell.
50. A method of treating an HIV infection in a patient, comprising:
administering to the patient a therapeutically effective amount of at least one compound of claim 1, or a pharmaceutically acceptable salt, solvate, or ester thereof.
51. The method of claim 50, further comprising:
co-administering at least one additional active agent.
52. The method of claim 51, wherein:
said at least one additional active agent is selected from the group consisting of:
HIV protease inhibiting compounds, HIV non-nucleoside inhibitors of reverse transcriptase, HIV nucleoside inhibitors of reverse transcriptase, HIV
nucleotide inhibitors of reverse transcriptase, HIV integrase inhibitors, gp4l inhibitors, CXCR4 inhibitors, entry inhibitors, gp120 inhibitors, G6PD and NADH-oxidase inhibitors, CCR5 inhibitors, other drugs for treating HIV, and mixtures thereof.
53. The method of claim 52, wherein:

(1) said I-IIV protease inhibitors are selected from the group consisting of amprenavir, atazanavir, fosamprenavir, indinavir, lopinavir, ritonavir, nelfinavir, saquinavir, tipranavir, brecanavir, darunavir, TMC-126, TMC-114, mozenavir (DMP-450), JE-2147 (AG1776), L-756423, R00334649, KNI-272, DPC-681, DPC-684, GW640385X, DG17, PPL-100, DG35, and AG 1859;
(2) said HIV non-nucleoside inhibitors of reverse transcriptase are selected from the group consisting of capravirine, emivirine, delaviridine, efavirenz, nevirapine, (+) calanolide A, etravirine, GW5634, DPC-083, DPC-961, DPC-963, MIV-150, TMC-120, TMC-278 (rilpivirene), efavirenz, BILR 355 BS, VRX 840773, UK-453061, and RDEA806;
(3) said HIV nucleoside inhibitors of reverse transcriptase are selected from the group consisting of zidovudine, emtricitabine, didanosine, stavudine, zalcitabine, lamivudine, abacavir, amdoxovir, elvucitabine, alovudine, MIV-210, racivir ( -FTC), D-d4FC, emtricitabine, phosphazide, fozivudine tidoxil, apricitibine (AVX754), GS-7340, amdoxovir, KP-1461, and fosalvudine tidoxil (formerly HDP 99.0003);
(4) said HIV nucleotide inhibitors of reverse transcriptase are selected from the group consisting of tenofovir and adefovir;
(5) said HIV integrase inhibitors are selected from the group consisting of curcumin, derivatives of curcumin, chicoric acid,. derivatives of chicoric acid, 3,5-dicaffeoylquinic acid, derivatives of 3,5-dicaffeoylquinic acid, aurintricarboxylic acid, derivatives of aurintricarboxylic acid, caffeic acid phenethyl ester, derivatives of caffeic acid phenethyl ester, tyrphostin, derivatives of tyrphostin, quercetin, derivatives of quercetin, S-1360, zintevir (AR-177), elvitegravir, L-870812, and L-870810, MK-0518 (raltegravir), BMS-538158, GSK364735C, BMS-707035, MK-2048, and BA 011;
(6) said gp4l inhibitor are selected from the group consisting of enfuvirtide, sifuvirtide, FB006M, and TRI-1144;
(7) said CXCR4 inhibitor is AMD-070;
(8) said entry inhibitor is SP01A;
(9) said gp120 inhibitor is BMS-488043 or BlockAide/ CR;

(10) said G6PD and NADH-oxidase inhibitor is immunitin;
(11) said CCR5 inhibitors are selected from the group consisting of aplaviroc, vicriviroc, maraviroc, PRO-140, INCB15050, PF-232798 (Pfizer), and CCR5mAb004; and (12) said other drugs for treating HIV are selected from the group consisting of BAS-100, SPI-452, REP 9, SP-01A, TNX-355, DES6, ODN-93, ODN-112, VGV-1, PA-457 (bevirimat), Ampligen, HRG214, Cytolin, VGX-410, KD-247, AMZ 0026, CYT 99007A-221 HIV, DEBIO-025, BAY 50-4798, MDX010 (ipilimumab), PBS 119, ALG 889, and PA-1050040 (PA-040).
54. A method for treating AIDS or AIDS Related Complex comprising administering to a patient a therapeutically effective amount of at least one compound of claim 1, or a pharmaceutically acceptable salt, solvate, and / or ester thereof, to a patient in need of such treatment.
55. The method of claim 54, further comprising co-administering one or more HIV reverse transcriptase inhibitor, one or more HIV protease inhibitor, one or more HIV entry/fusion inhibitor, one or more HIV integrase inhibitor, one or more an HIV budding/maturation inhibitor, or combinations thereof.
56. A method of inhibiting the replication of a retrovirus comprising contacting said retrovirus with at least one compound of claim 1, or a pharmaceutically acceptable salt, solvate, and/or ester thereof.
57. The method of claim 56, further comprising contacting the retrovirus with one or more HIV reverse transcriptase inhibitor, one or more HIV protease inhibitor, one or more HIV entry/fusion inhibitor, one or more HIV integrase inhibitor, one or more an HIV budding/maturation inhibitor, or combinations thereof.
58. A phosphonate prodrug of claim 1, or a pharmaceutically acceptable salt, solvate, or ester thereof, which has the formula:
[DRUG]-(PPG)nn wherein:
DRUG is a compound of claim 1;
nn is 1, 2, or 3; and PPG is a phosphonate group A o.
59. The conjugate of claim 58, wherein [DRUG]-(PPG)nn is selected from the group consisting of one of the following Formulae:

wherein:
T1A is -O-Alk;
T1B is -O-Het;
T1C is -O-Alk-Het;
T2A is -Alk-NH-C(O)-O-Alk;
T2B is -Alk-NH-C(O)-O-Alk-Ar;

T2C is -Alk-NH-C(O)-O-Alk-Het;
T2D is -Alk-Het;
T2E is -O-Het;
T2F is -Alk-NH-C(O)-Alk;
X1A is -Ar;
X1B is -Ar-Ar;
X1C is -Ar-Het;
X1D is -Ar-O-Het;
X1E is -Ar-O-Alk-Het;
X1F is -Ar-NH-Het;
X2A is -Ar;
X2B is -Ar-Ar;
X2C is -Ar-Het;
X2D is -Ar-O-Het;
X2E is -Ar-O-Alk-Het;
X2F is -Ar-NH-Het;
Alk is a substituted or unsubstituted alkyl or a substituted or unsubstituted alkylene;
Het is a substituted or unsubstituted heterocyclyl or a substituted or unsubstituted heterocyclylene; and Ar is a substituted or unsubstituted aryl or a substituted or unsubstituted arylene.
60. A new compound, substantially as described herein.
61. A compound as described in claim 1, substantially as described herein and illustrated.
62. A new pharmaceutical composition or use for the preparation of a medicament, substantially as described herein.
63. A compound of claim 1 as a therapeutic substance.
64. The use of a compound of claim 1 for the manufacture of a medicament for the treatment of an HIV infection in a patient.
65. The use of claim 64, wherein said medicament further comprises at least one additional active agent.
66. The use of claim 65, wherein said at least one additional active agent is selected from the group consisting of HIV protease inhibiting compounds, H1V
non-nucleoside inhibitors of reverse transcriptase, HIV nucleoside inhibitors of reverse transcriptase, HIV nucleotide inhibitors of reverse transcriptase, HIV

integrase inhibitors, gp4l inhibitors, CXCR4 inhibitors, entry inhibitors, gp120 inhibitors, G6PD and NADH-oxidase inhibitors, CCR5 inhibitors, other drugs for treating HIV, and mixtures thereof.
67. The use of claim 66, wherein-(1) said HIV protease inhibitors are selected from the group consisting of amprenavir, atazanavir, fosamprenavir, indinavir, lopinavir, ritonavir, nelfinavir, saquinavir, tipranavir, brecanavir, darunavir, TMC-126, TMC-114, mozenavir (DMP-450), JE-2147 (AG1776), L-756423, R00334649, KNI-272, DPC-681, DPC-684, GW640385X, DG17, PPL-100, DG35, and AG 1859;
(2) said HIV non-nucleoside inhibitors of reverse transcriptase are selected from the group consisting of capravirine, emivirine, delaviridine, efavirenz, nevirapine, (+) calanolide A, etravirine, GW5634, DPC-083, DPC-961, DPC-963, MIV-150, TMC-120, TMC-278 (rilpivirene), efavirenz, BILR 355 BS, VRX 840773, UK-453061, and RDEA806;
(3) said hIV nucleoside inhibitors of reverse transcriptase are selected from the group consisting of zidovudine, emtricitabine, didanosine, stavudine, zalcitabine, lamivudine, abacavir, amdoxovir, elvucitabine, alovudine, MIV-210, racivir (~-FTC), D-d4FC, emtricitabine, phosphazide, fozivudine tidoxil, apricitibine (AVX754), GS-7340, amdoxovir, KP-1461, and fosalvudine tidoxil (formerly HDP 99.0003);
(4) said HIV nucleotide inhibitors of reverse transcriptase are selected from the group consisting of tenofovir and adefovir;
(5) said HIV integrase inhibitors are selected from the group consisting of curcumin, derivatives of curcumin, chicoric acid, derivatives of chicoric acid, 3,5-dicaffeoylquinic acid, derivatives of 3,5-dicaffeoylquinic acid, aurintricarboxylic acid, derivatives of aurintricarboxylic acid, caffeic acid phenethyl ester, derivatives of caffeic acid phenethyl ester, tyrphostin, derivatives of tyrphostin, quercetin, derivatives of quercetin, S-1360, zintevir (AR-177), elvitegravir, L-870812, and L-870810, MK-0518 (raltegravir), BMS-538158, GSK364735C, BMS-707035, MK-2048, and BA 011;
(6) said gp4l inhibitor are selected from the group consisting of enfuvirtide, sifuvirtide, FB006M, and TRI-1144;
(7) said CXCR4 inhibitor is AMD-070;
(8) said entry inhibitor is SP01A;
(9) said gp120 inhibitor is BMS-488043 or BlockAide/ CR;
(10) said G6PD and NADH-oxidase inhibitor is immunitin;
(11) said CCR5 inhibitors are selected from the group consisting of aplaviroc, vicriviroc, maraviroc, PRO-140, INCB15050, PF-232798 (Pfizer), and CCR5mAb004; and (12) said other drugs for treating HIV are selected from the group consisting of BAS-100, SPI-452, REP 9, SP-01A, TNX-355, DES6, ODN-93, ODN-112, VGV-1, PA-457 (bevirimat), Ampligen, HRG214, Cytolin, VGX-410, KD-247, AMZ 0026, CYT 99007A-221 HIV, DEBIO-025, BAY 50-4798, MDX010 (ipilimumab), PBS 119, ALG 889, and PA-1050040 (PA-040).
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US7723380B2 (en) 2010-05-25
JP2009544613A (en) 2009-12-17
WO2008011117A3 (en) 2008-04-17
ES2574831T3 (en) 2016-06-22

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