CA2657310A1 - Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions - Google Patents

Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions Download PDF

Info

Publication number
CA2657310A1
CA2657310A1 CA002657310A CA2657310A CA2657310A1 CA 2657310 A1 CA2657310 A1 CA 2657310A1 CA 002657310 A CA002657310 A CA 002657310A CA 2657310 A CA2657310 A CA 2657310A CA 2657310 A1 CA2657310 A1 CA 2657310A1
Authority
CA
Canada
Prior art keywords
receptor
platelet
peptide
mimotope
ligand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002657310A
Other languages
English (en)
French (fr)
Inventor
Carlos A. Del Carpio Munoz
William Campbell
Iren Constantinescu
Dana V. Devine
Maria I.C. Gyongyossy-Issa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2657310A1 publication Critical patent/CA2657310A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
CA002657310A 2006-07-11 2006-10-17 Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions Abandoned CA2657310A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/484,364 US20080015145A1 (en) 2006-07-11 2006-07-11 Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
US11/484,364 2006-07-11
PCT/CA2006/001699 WO2008006189A1 (en) 2006-07-11 2006-10-17 Mimotope receptors and inhibitors for platelet- platelet and platelet-endothelium interactions

Publications (1)

Publication Number Publication Date
CA2657310A1 true CA2657310A1 (en) 2008-01-17

Family

ID=38922868

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002657310A Abandoned CA2657310A1 (en) 2006-07-11 2006-10-17 Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions

Country Status (4)

Country Link
US (2) US20080015145A1 (US07919465-20110405-P00006.png)
EP (2) EP2471812A1 (US07919465-20110405-P00006.png)
CA (1) CA2657310A1 (US07919465-20110405-P00006.png)
WO (1) WO2008006189A1 (US07919465-20110405-P00006.png)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2600220C (en) * 2006-09-07 2014-12-09 Canadian Blood Services Surface cross-linked lipidic particles, methods of production and uses therefor
CN101882927B (zh) * 2010-07-01 2012-07-04 西北工业大学 一种交流固态功率控制器的软开关装置
US10897891B2 (en) 2015-04-10 2021-01-26 Board Of Regents, The University Of Texas System Compositions and methods for prolonged cell storage
CN112121231B (zh) * 2020-09-18 2023-02-21 太阳雨林（厦门）生物医药有限公司 一种人工血小板

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4550163A (en) 1979-02-05 1985-10-29 Abbott Laboratories Ligand analog-irreversible enzyme inhibitor conjugates
NZ215865A (en) * 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
ATE120206T1 (de) * 1986-05-30 1995-04-15 Scripps Clinic Res Peptide, die die bindung des von-willebrand- faktors inhibieren.
US5238919A (en) * 1986-05-30 1993-08-24 Scipps Clinic And Research Foundation Peptides that inhibit von Willebrand Factor binding to the platelet SPIB receptor
US5900476A (en) * 1986-05-30 1999-05-04 The Scripps Research Institute Therapeutic domains of van Willebrand factor
US5114842A (en) * 1987-07-08 1992-05-19 The Scripps Research Institute Peptides and antibodies that inhibit platelet adhesion
US5428008A (en) * 1989-04-14 1995-06-27 Prp, Inc. Therapeutic composition of micellar structures capable of promoting hemotasis
US5328840A (en) * 1989-08-15 1994-07-12 The Research Foundation Of The State University Of New York Method for preparing targeted carrier erythrocytes
US6008193A (en) * 1990-03-02 1999-12-28 Bio-Technology General Corp. Methods of using human von Willebrand factor GPIb binding domain polypeptides
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
US5321127A (en) * 1991-03-18 1994-06-14 Brigham And Women's Hospital Antiplatelet and antithrombotic activity of platelet glycoprotein Ib receptor fragments
US6117974A (en) * 1991-10-02 2000-09-12 Peptor Limited Libraries of backbone-cyclized peptidomimetics
US5336667A (en) * 1991-12-03 1994-08-09 Temple University Of The Commonwealth System Of Higher Education Method for inhibiting the ahesion of platelet with alboaggregins: platelet agonists which bind to platelet membrane glycoprotein IB
AU3326693A (en) * 1991-12-12 1993-07-19 Scripps Research Institute, The Bifunctional antithrombotic molecules and antithrombotic polypeptides
EP0662088B1 (en) * 1993-07-01 2001-12-12 MERCK PATENT GmbH Inhibitor of collagen-stimulated platelet aggregation
US6139832A (en) * 1995-02-08 2000-10-31 Human Genome Sciences, Inc. Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides
US5877155A (en) * 1995-03-17 1999-03-02 The Research Foundation Of State University Of New York Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX
US5817748A (en) * 1995-03-17 1998-10-06 The Research Foundation Of State University Of New York Mimotopes of human Platelet glycoprotein Ib/IX
JP3735921B2 (ja) * 1996-02-07 2006-01-18 三菱ウェルファーマ株式会社 ＧＰＩｂ・脂質複合体およびその用途
US6586210B1 (en) * 1996-08-23 2003-07-01 Human Genome Sciences, Inc. Polynucleotides encoding T1 receptor like ligand II
AU718956B2 (en) * 1996-10-21 2000-05-04 Quadrant Healthcare (Uk) Limited Platelet substitutes and conjugation methods suitable for their preparation
CA2294494A1 (en) * 1997-06-05 1998-12-10 Richard C. K. Yen Fibrinogen-coated microspheres
US6858210B1 (en) * 1998-06-09 2005-02-22 La Jolla Pharmaceutical Co. Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
IL125262A0 (en) * 1998-07-07 1999-03-12 Yeda Res & Dev Synthetic peptides and pharmaceutical compositions comprising them
US6747135B1 (en) * 1998-10-16 2004-06-08 The Board Of Trustees For The Leland Stanford Junior University Fluorescent dye binding peptides
AU767172B2 (en) * 1999-03-18 2003-11-06 Merck Patent Gmbh Protein for blocking platelet adhesion
GB9918788D0 (en) * 1999-08-10 1999-10-13 Leuven K U Res & Dev Antithrombotic effect of platelet glycoprotein 1b blocking monoclonal Fab fragments
ATE374785T1 (de) * 2000-03-02 2007-10-15 Mitsubishi Pharma Corp Gpib-gebundenes konstrukt und verwendungen davon
WO2001085208A2 (en) * 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines
AR035779A1 (es) * 2001-02-06 2004-07-14 Genetics Inst Llc Polipeptidos de fusion derivados de glicoproteina ib alfa de plaqueta y metodos de uso de los mismos
US6836884B1 (en) * 2001-06-04 2004-12-28 Microsoft Corporation Method and system for editing software programs
ES2542330T3 (es) * 2003-01-10 2015-08-04 Ablynx N.V. Polipéptidos terapéuticos, homólogos de los mismos, fragmentos de los mismos y su uso en modular la agregación mediada por plaquetas
CA2600220C (en) * 2006-09-07 2014-12-09 Canadian Blood Services Surface cross-linked lipidic particles, methods of production and uses therefor

Also Published As

Publication number Publication date
EP2046827A4 (en) 2009-11-25
EP2046827A1 (en) 2009-04-15
EP2471812A1 (en) 2012-07-04
US20100075908A1 (en) 2010-03-25
US7919465B2 (en) 2011-04-05
WO2008006189A1 (en) 2008-01-17
US20080015145A1 (en) 2008-01-17

Similar Documents

Publication Publication Date Title
EP0730607B1 (en) Novel integrin-binding peptides
US5817750A (en) Structural mimics of RGD-binding sites
Nierodzik et al. Thrombin stimulates tumor-platelet adhesion in vitro and metastasis in vivo.
Koivunen et al. Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins
Berliner et al. Generation and characterization of peptide-specific antibodies that inhibit von Willebrand factor binding to glycoprotein IIb-IIIa without interacting with other adhesive molecules. Selectivity is conferred by Pro1743 and other amino acid residues adjacent to the sequence Arg1744-Gly1745-Asp1746.
Frazier Thrombospondin: a modular adhesive glycoprotein of platelets and nucleated cells.
Pierschbacher et al. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
Mumby et al. Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen.
Ochsenhirt et al. Effect of RGD secondary structure and the synergy site PHSRN on cell adhesion, spreading and specific integrin engagement
Curtis et al. Fibronectin attenuates increased endothelial monolayer permeability after RGD peptide, anti-alpha 5 beta 1, or TNF-alpha exposure
US7223734B2 (en) Plasma protein-binding ligands
CA2599849C (en) Synthetic platelets
CA2046631A1 (en) Hydrophobic attachment site for adhesion peptides
US20080015145A1 (en) Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
Skubitz et al. Definition of a sequence, RYVVLPR, within laminin peptide F-9 that mediates metastatic fibrosarcoma cell adhesion and spreading
AU600112B2 (en) Peptides with laminin activity
Flores et al. Bone sialoprotein coated on glass and plastic surfaces is recognized by different β3integrins
Hamaguchi et al. Spreading of platelets on fibrin is mediated by the amino terminus of the beta chain including peptide beta 15-42
US5276136A (en) Laminin A chain polypeptides from the amino terminal globular domain
JP2003507389A (ja) プロテアーゼ活性化レセプター１のトロンビン活性の選択的インヒビターとしてのペプチドアナログ
Takano et al. Real‐time analysis of the calcium‐dependent interaction between calmodulin and a synthetic oligopeptide of calcineurin by a surface plasmon resonance biosensor
WO1992013887A1 (en) New cell adhesion peptides
CA2524277A1 (en) Arg-pro-pro-gly-phe analogs as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
WO2011095604A1 (en) Half-life prolongation of proteins
CN100445296C (zh) 多肽有机化合物及其在异种移植中的应用

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20170731

FZDE Discontinued

Effective date: 20170731