CA2635062A1 - Antimicrobial coating methods - Google Patents

Antimicrobial coating methods Download PDF

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Publication number
CA2635062A1
CA2635062A1 CA002635062A CA2635062A CA2635062A1 CA 2635062 A1 CA2635062 A1 CA 2635062A1 CA 002635062 A CA002635062 A CA 002635062A CA 2635062 A CA2635062 A CA 2635062A CA 2635062 A1 CA2635062 A1 CA 2635062A1
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CA
Canada
Prior art keywords
substrate
silver
film
metal
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002635062A
Other languages
French (fr)
Other versions
CA2635062C (en
Inventor
Daniel M. Storey
Deidre Sewell
John H. Peterson
Terrence S. Mcgrath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chameleon Scientific Corp
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/741,015 external-priority patent/US20050003019A1/en
Application filed by Individual filed Critical Individual
Publication of CA2635062A1 publication Critical patent/CA2635062A1/en
Application granted granted Critical
Publication of CA2635062C publication Critical patent/CA2635062C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/24—Vacuum evaporation
    • C23C14/32—Vacuum evaporation by explosion; by evaporation and subsequent ionisation of the vapours, e.g. ion-plating
    • C23C14/325—Electric arc evaporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/10—Inorganic materials
    • A61L29/106—Inorganic materials other than carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/06—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
    • C23C14/08—Oxides
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/06—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the coating material
    • C23C14/14—Metallic material, boron or silicon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Metallurgy (AREA)
  • Mechanical Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Ceramic Engineering (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dentistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention is directed to efficient methods for depositing highly adherent anti¬ microbial materials onto a wide range of surfaces. A controlled cathodic arc process is described, which results in enhanced adhesion of silver oxide to polymers and other surfaces, such as surfaces of medical devices.
Deposition of anti-microbial materials directly onto the substrates is possible in a cost-effective manner that maintains high anti-microbial activity over several weeks when the coated devices are employed in vivo.

Claims (26)

1. A cathodic arc ion plasma deposition method for producing an anti-microbial coating on a substrate, comprising:

positioning a selected substrate between an anode and a cathode target, said target comprising an ionizable metal;

introducing oxygen gas into a vacuum chamber which houses the cathode target and the substrate, wherein the chamber is pressurized to about 0.1 to about 30 mTorr;

producing an arc discharge between the anode and the cathode target wherein power to said arc is optionally variably controlled to produce particles in the range of 1 nm to 50 microns; and adjusting movement of the substrate toward or away from the target within a range of about 1 inch to about 50 inches for a predetermined time at a temperature of between about 25°C and about 75°C during arc discharge to deposit a high density, adherent anti-microbial coating having a thickness of about 50 nm to about 5 microns on the substrate.
2. The method of claim 1 wherein power to the arc is externally controlled by at a single variable power supply or by at least two independently variable power supplies attached in opposed positions to the cathode target.
3. The method of claim 2 wherein power to the arc is adjusted to about 12 to about 60 volts providing between 5 and about 500 amps during deposition of a 100-200 nm coating on the substrate.
4. The method of claim 1 wherein the ionizable metal is a metal selected from the group consisting of silver, gold, platinum, copper, tantalum, titanium, zirconium, hafnium, and zinc.
5. The method of claim 4 wherein the metal is silver.
6. The method of claim 1 wherein the substrate comprises a metal.
7. The method of claim 6 wherein the substrate is selected from the group consisting of titanium, steel, chromium, zirconium, nickel, alloys and combinations thereof.
8. The method of claim 1 wherein the substrate comprises a polymer or ceramic
9. The method of claim 8 wherein the polymer is polypropylene, polyurethane, EPTFE, PTFE, polyimide, polyester, PEEK, UHMWPE, or nylon or combinations thereof.
10. The method of claim 9 wherein the polymer is PEEK or polyethylene.
11. A highly adherent Ag/AgO anti-microbial film deposited on a metal substrate wherein the Ag/AgO impregnates the substrate up to a depth of about 10 nanometers.
12. A highly adherent Ag/AgO anti-microbial film deposited on a polymeric substrate wherein the Ag/AgO impregnates the surface up to a depth of about 100 nanometers.
13. The Ag/AgO anti-microbial film of claim 11 which is deposited on a metal selected from the group consisting of titanium, steel, chromium, zirconium, nickel, combinations and alloys thereof.
14. The Ag/AgO anti-microbial film of claim 12 which is deposited on a polymeric substrate comprising a polymer selected from the group consisting of polypropylene, polyurethane, EPTFE, PTFE, polyimide, polyester, PEEK, UHMWPE, or nylon and combinations thereof.
15. The substrate of claim 1 which comprises a device selected from the group consisting of catheters, valves, stents and implants.
16. The substrate of claim 15 wherein the device is a catheter.
17. The substrate of claim 15 wherein the catheters, valves, stents and implants comprise a polymer, a metal, a ceramic or combinations thereof.
18. The substrate of claim 16 wherein the catheter comprises a polymer.
19. The substrate of claim 18 wherein the polymer is selected from the group consisting of polypropylene, polyurethane, EPTFE, PTFE, polyimide, polyester, PEEK, UHMWPE, and nylon.
20. A cathodic arc ion plasma deposition method for increasing antimicrobial activity in a silver/silver oxide ion plasma deposited film, comprising adjusting the distance of a substrate from a cathodic arc target and monitoring the amount of silver deposited in the film in relation to the distance of the substrate from the target, wherein increased antimicrobial activity of the film correlates with a decrease in the silver/silver oxide ratio in the film.
21. The method of claim 20 further comprising adjusting arc speed and monitoring particle size of deposited silver/silver oxide wherein an increase in number of macro particles increases antimicrobial activity of the film.
22. A coating prepared by the method of claim 21.
23. The method of claim 20 or 21 further comprising increasing deposition time to obtain a desired film thickness.
24. A silver/silver oxide anti-microbial film deposited on a metal, polymer or ceramic surface wherein the silver/silver oxide is imbedded in the metal surface to a depth of about 10 nm to about 10 nm, said film has a thickness of between about 50 nm to about 5 microns, which maintains anti-microbial activity for at least up to 28 days subsequent to use.
25. The silver/silver oxide anti-microbial film of claim 24 which is deposited on the surface of a metal, polymer or ceramic medical device.
26. The film of claim 25 wherein the medical device is a catheter, stent, implant or valve.
CA2635062A 2002-12-18 2007-01-19 Antimicrobial coating methods Active CA2635062C (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US43478402P 2002-12-18 2002-12-18
US10/741,015 US20050003019A1 (en) 2002-12-18 2003-12-18 Ionic plasma deposition of anti-microbial surfaces and the anti-microbial surfaces resulting therefrom
US76276906P 2006-01-27 2006-01-27
US60/762,769 2006-01-27
US76326206P 2006-01-30 2006-01-30
US60/763,262 2006-01-30
US77653706P 2006-02-25 2006-02-25
US60/776,537 2006-02-25
US77991706P 2006-03-06 2006-03-06
US60/779,917 2006-03-06
PCT/US2007/001695 WO2007087269A2 (en) 2002-12-18 2007-01-19 Antimicrobial coating methods

Publications (2)

Publication Number Publication Date
CA2635062A1 true CA2635062A1 (en) 2007-08-02
CA2635062C CA2635062C (en) 2010-10-26

Family

ID=43939635

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2635062A Active CA2635062C (en) 2002-12-18 2007-01-19 Antimicrobial coating methods

Country Status (3)

Country Link
CA (1) CA2635062C (en)
DK (1) DK1996744T3 (en)
WO (1) WO2007087269A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10995400B2 (en) * 2010-04-16 2021-05-04 Guardian Glass, LLC Method of making coated article having antibacterial and/or antifungal coating and resulting product
US20110256408A1 (en) * 2010-04-16 2011-10-20 Guardian Industries Corp., Method of making coated article having anti-bacterial and/or anti-fungal coating and resulting product
DE102011001403A1 (en) * 2011-03-18 2012-09-20 Frank-Peter Spahn Dental implant and method for producing or processing a dental implant
US8647675B2 (en) 2012-03-08 2014-02-11 Pacesetter, Inc. Silver nanoparticle antimicrobial coating for long-term and short-term infection resistance
EP3036353B1 (en) * 2013-08-20 2022-01-26 MDS Coating Technologies Corp. Coating containing macroparticles and cathodic arc process of making the coating
EP3372254A1 (en) 2017-03-09 2018-09-12 INP Greifswald Leibniz-institut Fuer Plasmaforschung Und Technologie E. V. Antibacterial surface modification for medical devices
SE545102C2 (en) * 2018-04-25 2023-04-04 Bactiguard Ab A surface coating for use in the prophylaxis of allergy
CN112941442B (en) * 2019-01-30 2022-12-27 浙江华达新型材料股份有限公司 Preparation process of steel plate surface coating based on heat treatment
CN115777028A (en) * 2020-04-06 2023-03-10 凯普里昂公司 Process for preparing anti-inflammatory, antibacterial, antifungal and virucidal materials
CN114159619B (en) * 2021-10-29 2023-03-17 青岛大学 Preparation method of antibacterial slow-release titanium tablet

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4828832A (en) 1983-09-07 1989-05-09 Laboratorios Biochemie De Mexico Method of manufacturing a composition for treating skin lesions
US5681575A (en) * 1992-05-19 1997-10-28 Westaim Technologies Inc. Anti-microbial coating for medical devices
US6333093B1 (en) * 1997-03-17 2001-12-25 Westaim Biomedical Corp. Anti-microbial coatings having indicator properties and wound dressings
US6103074A (en) * 1998-02-14 2000-08-15 Phygen, Inc. Cathode arc vapor deposition method and apparatus
EP1456432A1 (en) 2001-11-15 2004-09-15 Ionic Fusion Corporation Ionic plasma deposition apparatus
AU2003299685A1 (en) 2002-12-18 2004-07-22 Ionic Fusion Corporation Ionic plasma deposition of anti-microbial surfaces and the anti-microbial surfaces resulting therefrom

Also Published As

Publication number Publication date
WO2007087269A2 (en) 2007-08-02
WO2007087269A3 (en) 2007-10-25
DK1996744T3 (en) 2011-05-09
CA2635062C (en) 2010-10-26

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