CA2629957A1 - Tablets comprising a core and a medicament-containing coating for buccal release - Google Patents
Tablets comprising a core and a medicament-containing coating for buccal release Download PDFInfo
- Publication number
- CA2629957A1 CA2629957A1 CA002629957A CA2629957A CA2629957A1 CA 2629957 A1 CA2629957 A1 CA 2629957A1 CA 002629957 A CA002629957 A CA 002629957A CA 2629957 A CA2629957 A CA 2629957A CA 2629957 A1 CA2629957 A1 CA 2629957A1
- Authority
- CA
- Canada
- Prior art keywords
- product
- coating
- medicament
- group
- chosen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011248 coating agent Substances 0.000 title claims abstract 15
- 238000000576 coating method Methods 0.000 title claims abstract 15
- 239000003814 drug Substances 0.000 title claims abstract 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract 5
- 238000000034 method Methods 0.000 claims abstract 4
- 239000000047 product Substances 0.000 claims 20
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims 3
- 108010011485 Aspartame Proteins 0.000 claims 3
- 239000004376 Sucralose Substances 0.000 claims 3
- 239000000605 aspartame Substances 0.000 claims 3
- 235000010357 aspartame Nutrition 0.000 claims 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims 3
- 229960003438 aspartame Drugs 0.000 claims 3
- 235000009508 confectionery Nutrition 0.000 claims 3
- 239000008123 high-intensity sweetener Substances 0.000 claims 3
- 235000013615 non-nutritive sweetener Nutrition 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 3
- 235000019408 sucralose Nutrition 0.000 claims 3
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 3
- 239000006188 syrup Substances 0.000 claims 3
- 235000020357 syrup Nutrition 0.000 claims 3
- YIKYNHJUKRTCJL-UHFFFAOYSA-N Ethyl maltol Chemical compound CCC=1OC=CC(=O)C=1O YIKYNHJUKRTCJL-UHFFFAOYSA-N 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 229940093503 ethyl maltol Drugs 0.000 claims 2
- CBOQJANXLMLOSS-UHFFFAOYSA-N ethyl vanillin Chemical compound CCOC1=CC(C=O)=CC=C1O CBOQJANXLMLOSS-UHFFFAOYSA-N 0.000 claims 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 239000011707 mineral Substances 0.000 claims 2
- 235000010755 mineral Nutrition 0.000 claims 2
- 235000019204 saccharin Nutrition 0.000 claims 2
- 229940081974 saccharin Drugs 0.000 claims 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims 2
- 239000006068 taste-masking agent Substances 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims 1
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 claims 1
- 244000144730 Amygdalus persica Species 0.000 claims 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims 1
- 235000016623 Fragaria vesca Nutrition 0.000 claims 1
- 240000009088 Fragaria x ananassa Species 0.000 claims 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims 1
- 229930091371 Fructose Natural products 0.000 claims 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- 239000005715 Fructose Substances 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 244000303040 Glycyrrhiza glabra Species 0.000 claims 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims 1
- 239000004378 Glycyrrhizin Substances 0.000 claims 1
- 235000017443 Hedysarum boreale Nutrition 0.000 claims 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 235000006679 Mentha X verticillata Nutrition 0.000 claims 1
- 235000002899 Mentha suaveolens Nutrition 0.000 claims 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims 1
- 235000006040 Prunus persica var persica Nutrition 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 229940035674 anesthetics Drugs 0.000 claims 1
- 230000000954 anitussive effect Effects 0.000 claims 1
- 229940069428 antacid Drugs 0.000 claims 1
- 239000003159 antacid agent Substances 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000003434 antitussive agent Substances 0.000 claims 1
- 229940124584 antitussives Drugs 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 229940121357 antivirals Drugs 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000002327 cardiovascular agent Substances 0.000 claims 1
- 229940125692 cardiovascular agent Drugs 0.000 claims 1
- 235000019219 chocolate Nutrition 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 235000019221 dark chocolate Nutrition 0.000 claims 1
- 239000000850 decongestant Substances 0.000 claims 1
- 229940124581 decongestants Drugs 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 229940030606 diuretics Drugs 0.000 claims 1
- 229940073505 ethyl vanillin Drugs 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 235000012209 glucono delta-lactone Nutrition 0.000 claims 1
- 239000000182 glucono-delta-lactone Substances 0.000 claims 1
- 229960003681 gluconolactone Drugs 0.000 claims 1
- 229960002449 glycine Drugs 0.000 claims 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims 1
- 229960004949 glycyrrhizic acid Drugs 0.000 claims 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims 1
- 235000019410 glycyrrhizin Nutrition 0.000 claims 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 239000000905 isomalt Substances 0.000 claims 1
- 235000010439 isomalt Nutrition 0.000 claims 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims 1
- 239000000845 maltitol Substances 0.000 claims 1
- 235000010449 maltitol Nutrition 0.000 claims 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 1
- 229940035436 maltitol Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 229940035363 muscle relaxants Drugs 0.000 claims 1
- 239000003158 myorelaxant agent Substances 0.000 claims 1
- 239000002417 nutraceutical Substances 0.000 claims 1
- 235000021436 nutraceutical agent Nutrition 0.000 claims 1
- 239000000176 sodium gluconate Substances 0.000 claims 1
- 235000012207 sodium gluconate Nutrition 0.000 claims 1
- 229940005574 sodium gluconate Drugs 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 239000000021 stimulant Substances 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 claims 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims 1
- 235000012141 vanillin Nutrition 0.000 claims 1
- 235000019222 white chocolate Nutrition 0.000 claims 1
- 235000019220 whole milk chocolate Nutrition 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
- 239000011670 zinc gluconate Substances 0.000 claims 1
- 235000011478 zinc gluconate Nutrition 0.000 claims 1
- 229960000306 zinc gluconate Drugs 0.000 claims 1
- 230000001055 chewing effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
Abstract
Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the products. The products include a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a consumable center. By chewing the products, the medicament or agent is released from the product within the buccal cavity.
Claims (16)
1. A product including a medicament comprising:
(a) a consumable center having a hardness of about 4-6 KPA; and (b) a coating including a medicament that surrounds the consumable center.
(a) a consumable center having a hardness of about 4-6 KPA; and (b) a coating including a medicament that surrounds the consumable center.
2. The product of Claim 1 wherein the coating comprises a first powder coating and a second syrup coating.
3. The product of Claim 1 wherein the coating comprises a first coating comprising a medicament and a second coating comprising a fat-based confectionery product.
4. The product of any of the preceding Claims wherein the coating is at least 50% by weight of the product.
5. The product of any of the preceding Claims, wherein the consumable center is tableted.
6. The product of any of Claims 3-5, wherein the fat-based confectionery comprises an ingredient selected from the group consisting of white chocolate, dark chocolate, milk chocolate and combinations thereof.
7. The product of any of Claims 3-6, wherein the fat-based confectionery comprises a flavor selected from the group consisting of chocolate, strawberry cream, orange, peach and mint and combinations thereof.
8. The product of any of the preceding Claims, wherein the coating includes a high-intensity sweetener.
9. The product of Claim 8, wherein the high-intensity sweetener is chosen from the group consisting of aspartame, sucralose, saccharin, and acesulfame-k.
10. The product of any of the preceding Claims, wherein the consumable center is selected from the group consisting of a gurnmi confectionary, hard confectionary, confectionary starch, compressed saccharides, and compressed sugar alcohols.
11. The product of any of the preceding Claims, wherein the medicament is chosen from the group consisting of: analgesics; muscle relaxants; antibiotics;
antivirals;
stimulants; antihistamines; decongestants; anti-inflammatories; antacids;
psychotherapeutic agents; insulin; vitamins; minerals; nutraceuticals;
nutritional supplements; diuretics; vitamins; minerals; anesthetics; antitussives;
bioengineered pharmaceuticals; and cardiovascular agents.
antivirals;
stimulants; antihistamines; decongestants; anti-inflammatories; antacids;
psychotherapeutic agents; insulin; vitamins; minerals; nutraceuticals;
nutritional supplements; diuretics; vitamins; minerals; anesthetics; antitussives;
bioengineered pharmaceuticals; and cardiovascular agents.
12. The product of any of the preceding Claims, wherein the coating includes a taste masking agent.
13. The product of Claim 12, wherein the taste masking agent is chosen from the group consisting of: zinc gluconate, ethyl maltol, glycine, acesulfame-k, aspartame;
saccharin; fructose; xylitol; isomalt; maltitol; spray dried licorice root;
glycyrrhizin;
sodium gluconate; glucono delta-lactone; ethyl vanillin; dextrose; sucralose;
vanillin;
and ethyl maltol.
saccharin; fructose; xylitol; isomalt; maltitol; spray dried licorice root;
glycyrrhizin;
sodium gluconate; glucono delta-lactone; ethyl vanillin; dextrose; sucralose;
vanillin;
and ethyl maltol.
14. The product of any of the preceding Claims, wherein the coating includes approximately 0.1% to about 5% by weight of a high-intensity sweetener chosen from the group consisting of aspartame, sucralose, saccharine, and acesulfame-k.
15. A method of manufacturing the product of any of the preceding Claims the method comprising:
(a) preparing a tableted consumable center having a hardness of about 4-6 KPA; and (b) coating the tableted consumable center by placing layers of a powder and a syrup on the center to create a coated product, at least one of the powder or syrup layers including at least a medicament.
(a) preparing a tableted consumable center having a hardness of about 4-6 KPA; and (b) coating the tableted consumable center by placing layers of a powder and a syrup on the center to create a coated product, at least one of the powder or syrup layers including at least a medicament.
16. A method for delivering a medicament to an individual comprising placing the product of any of the preceding claims in the mouth of the individual and causing the medicament to be released from the product into the buccal cavity of the individual
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2005/041236 WO2007058645A1 (en) | 2005-11-15 | 2005-11-15 | Tablets comprising a core and a medicament-containing coating for buccal release |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2629957A1 true CA2629957A1 (en) | 2007-05-24 |
| CA2629957C CA2629957C (en) | 2012-07-24 |
Family
ID=36819274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2629957A Active CA2629957C (en) | 2005-11-15 | 2005-11-15 | Tablets comprising a core and a medicament-containing coating for buccal release |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1951196A1 (en) |
| CA (1) | CA2629957C (en) |
| WO (1) | WO2007058645A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2934780B1 (en) * | 2008-08-06 | 2013-01-04 | Docteur Gaetano Zannini Lab | PHARMACEUTICAL COMPOSITION IN THE FORM OF PELLETS AND PROCESS FOR PRODUCING SUCH A PHARMACEUTICAL COMPOSITION. |
| CN108712900A (en) | 2015-12-19 | 2018-10-26 | 第时间美国泛型药物有限公司 | Soft chewable tablet pharmaceutical preparation |
| US20190022013A1 (en) | 2015-12-19 | 2019-01-24 | First Time Us Generics Llc | Soft-chew tablet pharmaceutical formulations |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5759577A (en) * | 1995-01-17 | 1998-06-02 | American Home Products Corporation | Controlled release of steroids from sugar coatings |
| US20020110581A1 (en) * | 1999-04-06 | 2002-08-15 | Ream Ronald L. | Over-coated product including consumable center and medicament |
| US6426090B1 (en) * | 1999-04-06 | 2002-07-30 | Wm. Wrigley Jr. Company | Over-coated product including tableted center and medicament |
| US6322806B1 (en) * | 1999-04-06 | 2001-11-27 | Wm. Wrigley Jr. Company | Over-coated chewing gum formulations including tableted center |
-
2005
- 2005-11-15 WO PCT/US2005/041236 patent/WO2007058645A1/en active Application Filing
- 2005-11-15 EP EP05822314A patent/EP1951196A1/en not_active Withdrawn
- 2005-11-15 CA CA2629957A patent/CA2629957C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007058645A1 (en) | 2007-05-24 |
| EP1951196A1 (en) | 2008-08-06 |
| CA2629957C (en) | 2012-07-24 |
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