CA2629402A1 - Beta-secretase modulators and methods of use - Google Patents

Beta-secretase modulators and methods of use Download PDF

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CA2629402A1
CA2629402A1 CA002629402A CA2629402A CA2629402A1 CA 2629402 A1 CA2629402 A1 CA 2629402A1 CA 002629402 A CA002629402 A CA 002629402A CA 2629402 A CA2629402 A CA 2629402A CA 2629402 A1 CA2629402 A1 CA 2629402A1
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amino
acetamide
methyl
dihydrospiro
pyridin
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CA2629402C (en
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Wenge Zhong
Stephen Hitchcock
Brian K Albrecht
Michael Bartberger
James Brown
Ryan Brown (Deceased)
Stuart C. Chaffee
Yuan Cheng
Michael Croghan
Russell Graceffa
Scott Harried
Dean Hickman
Daniel Horne
Randall Hungate
Ted Judd
Matthew Kaller
Charles Kreiman
Daniel La
Patricia Lopez
Craig E. Masse
Holger Monenschein
Thomas Nguyen
Thomas Nixey
Vinod F. Patel
Lewis Pennington
Matthew Weiss
Qiufen Xue
Bryant Yang
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

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Abstract

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I);
wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula (I), methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula (I), or compositions including them, to a subject. The invention also comprises further embodiments of Formulas (II) and (III), intermediates and processes useful for the preparation of compounds of the invention.

Claims (28)

1. A compound of Formula I:

or stereoisomer, tautomer, solvate, pharmaceutically acceptable salt, derivative or prodrug thereof, wherein A is C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, R1-C1-10-alkyl-, R1-C2-10-alkenyl- or R1-C2-10-alkynyl-, wherein 1, 2 or 3 carbon atoms of (1) said C1-10 alkyl, C1-10 alkenyl, C1-10 alkynyl or (2) said C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl of R1-C1-10-alkyl-, R1-C2-10-alkenyl- or R1-C2-10-alkynyl-, is optionally replaced with a heteroatom selected from O, S, S(O), S(O)2 and N, and optionally substituted independently with one or more substituents of R9;
and R' is a fully saturated or a partially or fully unsaturated 4-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms and optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, wherein said ring system is substituted independently with one or more substituents of oxo, R7, R8, R9, NR7R7, NR7R8, OR7, SR7, OR8, SR8, C(O)R7, OC(O)R7, COOR7, C(O)R8, OC(O)R8, COOR8, C(O)NR7R7, C(S)NR7R7, NR7C(O)R7, NR7C(S)R7, NR7C(O)NR7R7, NR7C(S)NR7R7, NR7(COOR7), OC(O)NR7R7, C(O)NR7R8, C(S)NR7R8, NR7C(O)R8, NR7C(S)R8, NR7C(O)NR7R8, NR7C(S)NR7R8,, NR7(COOR8), OC(O)NR7R8, S(O)2NR7R7, NR7S(O)2NR7R7, NR7S(O)2R7 S(O)2R8, S(O)2NR7R8, NR7S(O)2NR7R8 or NR7S(O)2R8;
W is -C(=O)-, -OC(=O)-, -NHC(=O)-, -S(=O)b- or -NHS(=O)b-, wherein b is 1 or 2;
B is R2-(CR2aR2a)h-, R2-O-(CR2aR2a)h-, R2-S-(CR2aR2a)h- or R2-N(R2a)-(CR2aR2a)h-, wherein R2 is C1-C10 alkyl, C1-C1o haloalkyl, C1-C10 alkenyl, C1-C10 alkynyl or a partially or fully saturated or unsaturated 3-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from 0, N, or S, wherein said C1-C10 alkyl, C1-C10 alkenyl, C1-C10 alkynyl is optionally substituted independently with one or more substituents of R9, and said ring system is optionally substituted independently with one or more substituents of oxo, R7, R8, R9, NR7R7, NR7R8, OR7, SR7, OR8, SR8, C(O)R7, OC(O)R7, COOR7, C(O)R8, OC(O)R8, COOR8, C(O)NR7R7, C(S)NR7R7, NR7C(O)R7, NR7C(S)R7, NR7C(O)NR7R7, NR7C(S)NR7R7, NR7(COOR7), OC(O)NR7R7, C(O)NR7R8, C(S)NR7R8, NR7C(O)R8, NR7C(S)R8, NR7C(O)NR7R8, NR7C(S)NR7R8, NR7(COOR8), OC(O)NR7R8, S(O)2NR7R7, NR7S(O)2NR7R7, NR7S(O)2R7, S(O)2R8, S(O)2NR7R8, NR7S(O)2NR7R8 or NR7S(O)2R8;
each R2a, independently, is H, OH, NO2, CN, NH2, C1-C10 alkyl, C1-C10 alkoxyl or haloalkyl; and h is 0, 1, 2 or 3;
i is 1, 2 or 3;
j is 0, 1 or 2;
each R3, independently, is H, haloalkyl, CN, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl or C4-10-cycloalkenyl, each of the C1-10-alkyl, C2-10-alkenyl, C2.10-alkynyl, C3-10-cycloalkyl and C4-10-cycloalkenyl optionally comprising 1-4 heteroatoms selected from N, O and S and optionally substituted with 1-5 substituents of R8 or R9;
R4 is H, haloalkyl, CN, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl or C4-10-cycloalkenyl, each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl and C4-10-cycloalkenyl optionally comprising 1-4 heteroatoms selected from N, O and S
and optionally substituted with 1-5 substituents of R8 or R9;

R5 is wherein X1 is CR12, C(=O), O, S, S(O)2, or NR12;
each X2, independently, is CR12R12;
each of Y1, Y2 and Y3, independently, is CR12R12, O, S or NR12;
m is 0, 1 or 2; and o is 0, 1, 2, 3,4 or 5;
provided that (a) no more than two of Y1, Y2 and Y3 is O, S or NR12 and (b) when o is 0, then each of Y1 and Y2 is CR12R12;

R7 is H, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl or C4-10-cycloalkenyl, each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl and C4-10-cycloalkenyl optionally comprising 1-4 heteroatoms selected from N, O and S
and optionally substituted with 1-5 substituents of NR8R9, NR9R9, OR8, SR8, OR9, SR9, C(O)R8, OC(O)R8, COOR8, C(O)R9, OC(O)R9, COOR9, C(O)NR8R9, C(O)NR9R9, NR9C(O)R8, NR9C(O)R9, NR9C(O)NR8R9, NR9C(O)NR9R9, NR9(COOR8), NR9(COOR9), OC(O)NR8R9, OC(O)NR9R9, S(O)2R8, S(O)2NR8R9, S(O)2R9, S(O)2NR9R9, NR9S(O)2NR8R9, NR9S(O)2NR9R9, NR9S(O)2R8, NR9S(O)2R9, R8 or R9;
R8 is a partially or fully saturated or unsaturated 3-8 membered monocyclic, 6-membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, and wherein said ring system is optionally substituted independently with 1-5 substituents of R9, oxo, NR9R9, OR9; SR9, C(O)R9 or a partially or fully saturated or unsaturated 5-6 membered ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, and optionally substituted independently with 1-5 substituents of R9;
R9 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, C1-10-alkylamino-, dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl;
R10 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, C1-10-alkylamino-, dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl;
R11 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, C1-10-alkylamino-, dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl;
alternatively, R10 and R11 taken together with the carbon or nitrogen atoms to which they are attached form a partially or fully saturated or unsaturated 5-6 membered second ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, the second ring optionally substituted independently with 1-5 substituents of R12, R13, R14 or R15 and optionally fused to a 4-7 membered third ring, the third ring formed of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, and optionally substituted independently with 1-5 substituents of R12, R13, R14 or R15;
R12 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, oxo, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl, phenyl or R14;
R13 is NR14R15, NR15R15, OR14, SR14, OR15, SR15, C(O)R14, OC(O)R14, COOR14, C(O)R15, OC(O)R15, COOR15, C(O)NR14R15, C(O)NR15R15, NR14C(O)R14, NR15C(O)R14, NR14C(O)R15, NR15C(O)R15, NR15C(O)NR14R15, NR15C(O)NR15R15, NR15(COOR14), NR15(COOR15), OC(O)NR14R15, OC(O)NR15R15, S(O)2R14, S(O)2R15, S(O)2NR14R15, S(O)2NR15R15, NR14S(O)2NR14R15, NR15S(O)2NR15R15, NR14S(O)2R14 or NR15S(O)2R15;
R14 is a saturated or partially or fully unsaturated 3-8 membered monocyclic, membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, and wherein said ring system is optionally substituted independently with 1-5 substituents of R15; and R15 is H, halo, haloalkyl, CN, OH, NO2, NH2, oxo, acetyl, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, benzyl, phenyl, C1-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl or a partially or fully saturated or unsaturated 3-8 membered monocyclic or 6-12 membered bicyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, and optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, acetyl, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopentyl, hexyl, cyclohexyl, benzyl or phenyl.
2. The compound of Claim 1 wherein A is C1-6-alkyl, C2-6 alkenyl, C2-6-alkynyl, R1-O-C1-6-alkyl-, R1-S-C1-6-alkyl-, R1-S(O)2-C1-6-alkyl-, R1-NH-C1-6-alkyl-, R1-O-C1-6-alkenyl-, R1-S-C2-6-alkenyl-, R1-S(O)2-C2-6-alkenyl-, R1-alkenyl-, R1-O-C1-6-alkynyl-, R1-S-C1-6alkynyl-, R1-S(O)2-C1-6-alkynyl-, R1-NH-alkynyl-, R1-C1-6alkyl-O-C1-6-alkyl-, R1-C1-6-alkyl-S-C1-6-alkyl-, R1-C1-6-alkyl-S(O)2-C1-6-alkyl-, R1-C1-6-alkyl-NH-C1-6-alkyl-, R1-C1-6-alkyl-O-C1-6-alkenyl-, R1-C1-6-alkyl-S-C2-6-alkenyl-, R1-C1-6-alkyl-S(O)2-C2-6-alkenyl-, R1-C1-6-alkyl-NH-C2-6-alkenyl-, R1-C1-6-alkyl-O-C1-6-alkynyl-, R1-C1-6-alkyl-S-C1-6-alkynyl-, R1-C1-6-alkyl-S(O)2-C1-6alkynyl- or R1-C1-6-alkyl-NH-C1-6-alkynyl-.
3. The compound of Claim 1 wherein A is C1-6-alkyl, C2-6alkenyl, C2-6-alkynyl, C1-6alkyl-O-C1-3-alkyl-, C1-6-alkyl-S-C1-3-alkyl-, C1-6-alkyl-S(O)2-C1-3-alkyl-, C1-6-alkyl-NH-C1-3-alkyl, di-(C1-6-alkyl)-N-C1-3-alkyl, C2-6-alkenyl-O-C1-3-alkyl-, C2-6-alkenyl-S-C1-3-alkyl-, C2-6-alkenyl-S(O)2-C1-3-alkyl-, C2-6-alkenyl-NH-C1-3-alkyl- or C2-6-alkynyl-NH-C1-3-alkyl-, wherein the alkyl, alkenyl or alkynyl moiety of each is optionally substituted with 1-5 substituents of R9.
4. The compound of Claim 1 wherein R2 is a C1-C4alkyl, C1-C4alkenyl, C1-C4alkynyl, C1-C10 haloalkyl or an optionally substituted ring system selected from phenyl, naphthyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, triazinyl, quinolinyl, isoquinolinyl, quinazolinyl, isoquinazolinyl, phthalazinyl, thiophenyl, furyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl, oxazolyl, isoxazolyl, isothiazolyl, thiadiazolyl, oxadiazolyl, indolyl, isoindolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, tetrahydrofuranyl, pyrrolidinyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl.
5. The compound of Claim 1 wherein B is R2-O-(CR2a R2a)h-, R2-S-(CR2a R2a)h-or R2-N(R2a)-(CR2a R2a)h-, wherein each of R2, R2a and h are as defined in claim 1.
6. The compound of Claim 1 wherein each R3, independently, is H, haloalkyl, CN, C1-10alkyl, C2-10-alkenyl or C2-10-alkynyl;
R4 is H or C1-10-alkyl;
h is 1;
i is 1; and j is 0.
7. The compound of Claim 6 wherein R5 is wherein m, o, R12, X1, X2, Y1, Y2 and Y3 are as defined in claim 1;
Z2 taken together with the carbon atoms to which it is attached is a partially or fully unsaturated 5-8 membered monocyclic ring, said ring formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, provided that (a) no more than two of Y1, Y2 and Y3 is O, S or NR12 and (b) when o is 0, then each of Y1 and Y2 is CR12R12; and p is 0, 1, 2, 3, 4 or 5.
8. The compound of Claim 7 wherein Z2 is a phenyl, pyridine, pyrimidine, triazine, pyridazine, pyrazine, pyridone, pyrrole, imidazole, pyrazole, triazole, thiophene, thiazole, thiadiazole, isothiazole, furan, oxazole, oxadiazole or isoxazole ring.
9. The compound of Claim 1 wherein h is 1 or 2;
i is 1;
j is 0;
A is C1-6-alkyl, C2-6alkenyl, C2-6-alkynyl, C1-6alkyl-O-C1-3-alkyl-, C1-6-alkyl-S-C1-3-alkyl-, C1-6-alkyl-S(O)2-C1-3-alkyl-, C1-6-alkyl-NH-C1-3-alkyl, di-(C1-6-alkyl)-N-C1-3-alkyl, C2-6-alkenyl-O-C1-3-alkyl-, C2-6-alkenyl-S-C1-3-alkyl-, C2-6-alkenyl-S(O)2-C1-3-alkyl-, C2-6-alkenyl-NH-C1-3-alkyl- or C2-6-alkynyl-NH-C1-3-alkyl-, wherein the alkyl, alkenyl or alkynyl moiety of each is optionally substituted with 1-5 substituents of R9;
W is -C(=O)-;
B is R2-(CR2a R2a)h-, wherein h is 1 and R2 is a C1-C4alkyl, C1-C4alkenyl, C1-C4alkynyl, C1-C10 haloalkyl or an optionally substituted ring system selected from phenyl, naphthyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, triazinyl, quinolinyl, isoquinolinyl, quinazolinyl, isoquinazolinyl, phthalazinyl, thiophenyl, furyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl, oxazolyl, isoxazolyl, isothiazolyl, thiadiazolyl, oxadiazolyl, indolyl, isoindolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, tetrahydrofuranyl, pyrrolidinyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl;
each R3, independently, is H, haloalkyl, CN, C1-10-alkyl, C2-10-alkenyl or C2-
10-alkynyl;
R4 is H, CN or C1-10-alkyl;
R5 is wherein m, o, R12, X2, Y1, Y2 and Y3 are as defined in claim 1;
X1 is CR12, C(=O), O, S, S(O)2 or NR12;

Z2 is a phenyl, pyridine, pyrimidine, triazine, pyridazine, pyrazine, pyridone, pyrrole, imidazole, pyrazole, triazole, thiophene, thiazole, thiadiazole, isothiazole, furan, oxazole, oxadiazole or isoxazole ring; and p is 0, 1, 2, 3, 4 or 5.
R7 is H, C1-10-alkyl or C2-10-alkenyl, each of the C1-10-alkyl, or C2-10-alkenyl optionally substituted with 1-3 substituents of R9;
R8 is a ring system selected from phenyl, pyridyl, pyrimidinyl, triazinyl, quinolinyl, tetrahydroquinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, quinazolinyl, isoquinazolinyl, thiophenyl, furyl, tetrahydrofuranyl, pyrrolyl, pyrazolyl, thieno-pyrazolyl, imidazolyl, triazolyl, tetrazolyl, thiazolyl, thiadiazolyl, benzothiazolyl, oxazolyl, oxadiazolyl, benzoxazolyl, benzoxadiazolyl, isoxazolyl, isothiazolyl, indolyl, azaindolyl, 2,3-dihydroindolyl, isoindolyl, indazolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, imidazo-pyridinyl, purinyl, benzotriazolyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrrolidinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, 2,3-dihydro-1,4-benzoxazinyl, 1,3-benzodioxolyl, cyclopropyl, cyclobutyl, azetidinyl, cyclopentyl, cyclohexyl and cycloheptyl, said ring system optionally substituted independently with 1-3 substituents of R9, oxo, NR9R9, OR9, SR9, C(O)R9 or a partially or fully saturated or unsaturated 5-6 membered ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, and optionally substituted independently with 1-5 substituents of R9;
R9 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-7-cycloalkyl, C4-7-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl; and R12 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, oxo, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, Cl-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopently, hexyl, cyclohexyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl.

10. The compound of claim 9 wherein R5 is wherein m is 0 or 1;
o is 1 or 2;
p is 0, 1, 2 or 3;
A1 is CH, C(=O), O or NR12;
each of A1 and A2, independently, is CR12 or N, provided that no more than one of A1 and A2 is N;
X2 is CH;
Y3 is CR12 or O; and each R12, independently, is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, oxo, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a ring selected from phenyl, pyridyl, pyrimidinyl, triazinyl, thiophenyl, furyl, tetrahydrofuranyl, pyrrolyl, pyrazolyl, thieno-pyrazolyl, imidazolyl, triazolyl, tetrazolyl, thiazolyl, thiadiazolyl, oxazolyl, oxadiazolyl, isoxazolyl, isothiazolyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrrolidinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, cyclopropyl, cyclobutyl, azetidinyl, cyclopentyl, cyclohexyl and cycloheptyl, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopently, hexyl, cyclohexyl, C10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl.
11. A compound of Formula II:

or stereoisomer, tautomer, solvate, pharmaceutically acceptable salt, derivative or prodrug thereof, wherein A is C1-6-alkyl, C2-6-alkenyl, C2-6alkynyl, R1-C1-6-alkyl-, R1-C2-6-alkenyl-or R1-C2-6-alkynyl-, wherein 1, 2 or 3 carbon atoms of (1) said C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl or (2) said C1-6-alkyl, C2-6alkenyl, C2-6-alkynyl of R1-C1-6-alkyl-, R1-C2-6-alkenyl-or R1-C2-6-alkynyl-, is optionally replaced with a heteroatom selected from O, S, S(O), S(O)2 and NH, and optionally substituted independently with 1-3 substituents of R9; and R1 is phenyl, naphthyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, triazinyl, quinolinyl, isoquinolinyl, quinazolinyl, isoquinazolinyl, phthalazinyl, thiophenyl, furyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl, oxazolyl, isoxazolyl, isothiazolyl, thiadiazolyl, oxadiazolyl, indolyl, isoindolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, tetrahydrofuranyl, pyrrolidinyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl, each of which is optionally substituted 1-3 substituents of oxo, R8, R9, NR7R7, NR7R8, OR7, SR7, OR8, SR8, C(O)R7, OC(O)R7, COOR7, C(O)R8, OC(O)R8, COOR8, C(O)NR7R7, NR7C(O)R7, NR7C(O)NR7R7, NR7(COOR7), OC(O)NR7R7, C(O)NR7R8, NR7C(O)R8, NR7C(O)NR7R8, NR7(COOR8), OC(O)NR7R8, S(O)2NR7R7, NR7S(O)2NR7R7, NR7S(O)2R7, S(O)2R8, S(O)2NR7R8, NR7S(O)2NR7R8 or NR7S(O)2R8;
W is -C(=O)-, -OC(=O)-, -NHC(=O)-, -S(=O)b- or -NHS(=O)b-, wherein b is 1 or 2;

V is -(CR2a R2a)h-, -O-(CR2a R2a)h-, -S-(CR2a R2a)h- or -NR2a-(CR2a R2a)h-, wherein each R2a, independently, is H, C1-C10 alkyl or haloalkyl, and h is 0, 1 or 2;
R2 is a C1-C10alkyl, C1-C10haloalkyl, C1-C10alkenyl, C1-C10 alkynyl or a partially or fully saturated or unsaturated 3-8 membered monocyclic, 6-12 membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, wherein said ring system is optionally substituted independently with one or more substituents of oxo, R7, R8, R9, NR7R7, NR7R8, OR7, SR7, OR8, SR8, C(O)R7, OC(O)R7, COOR7, C(O)R8, OC(O)R8, COOR8, C(O)NR7R7, C(S)NR7R7, NR7C(O)R7, NR7C(S)R7, NR7C(O)NR7R7, NR7C(S)NR7R7, NR7(COOR7), OC(O)NR7R7, C(O)NR7R8, C(S)NR7R8, NR7C(O)R8, NR7C(S)R8, NR7C(O)NR7R8, NR7C(S)NR7R8, NR7(COOR8), OC(O)NR7R8, S(O)2NR7R7, NR7S(O)2NR7R7, NR7S(O)2R7, S(O)2R8, S(O)2NR7R8, NR7S(O)2NR7R8 or NR7S(O)2R8;
R3 is H, haloalkyl, CN, C1-10-alkyl, C2-10-alkenyl or C2-10-alkynyl;
R4 is H, haloalkyl, CN, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl or C4-10-cycloalkenyl, each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl and C4-10-cycloalkenyl optionally comprising 1-4 heteroatoms selected from N, O and S
and optionally substituted with 1-5 substituents of R8 or R9;
R8 is wherein X1 is C(=O), O, S, S(O)2 or NR12;
each X2, independently, is CR12R12; and m is 0, 1 or 2;
R7 is H, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl or C4-10-cycloalkenyl, each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl and C4-10-cycloalkenyl optionally comprising 1-4 heteroatoms selected from N, O and S
and optionally substituted with 1-5 substituents of NR8R9, NR9R9, OR8, SR8, OR9, SR9, C(O)R8, OC(O)R8, COOR8, C(O)R9, OC(O)R9, COOR9, C(O)NR8R9, C(O)NR9R9, NR9C(O)R8, NR9C(O)R9, NR9C(O)NR8R9, NR9C(O)NR9R9, NR9(COOR8), NR9(COOR9), OC(O)NR8R9, OC(O)NR9R9, S(O)2R8, S(O)2NR8R9, S(O)2R9, S(O)2NR9R9, NR9S(O)2NR8R9, NR9S(O)2NR9R9, NR9S(O)2R8, NR9S(O)2R9, R8 or R9;
R8 is a partially or fully saturated or unsaturated 3-8 membered monocyclic, 6-
12 membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, and wherein said ring system is optionally substituted independently with 1-5 substituents of R9, oxo, NR9R9, OR9; SR9, C(O)R9 or a partially or fully saturated or unsaturated 5-6 membered ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, and optionally substituted independently with 1-5 substituents of R9;
R9 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pently, cyclopently, hexyl, cyclohexyl, C1-10-alkylamino-, dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl;
R10 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pently, cyclopently, hexyl, cyclohexyl, C1-10-alkylamino-, dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl;
R11 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pently, cyclopently, hexyl, cyclohexyl, C1-10-alkylamino-, dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl;
alternatively, R10 and R11 taken together with the carbon atoms to which they are attached form a partially or fully saturated or unsaturated 5-6 membered ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, and the ring optionally substituted independently with 1-5 substituents of R12, R13, R14 or R15;
R12 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, oxo, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pently, cyclopently, hexyl, cyclohexyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl;
R13 is NR14R15, NR15R15, OR14; SR14, OR15; SR15, C(O)R14, OC(O)R14, COOR14, C(O)R15, OC(O)R15, COOR15, C(O)NR14R15, C(O)NR15R15, NR14C(O)R14, NR15C(O)R14, NR14C(O)R15, NR15C(O)R15, NR15C(O)NR14R15, NR15C(O)NR15R15, NR15(COOR14), NR15 (COOR15), OC(O)NR14R15, OC(O)NR15R15, S(O)2R14, S(O)2R15, S(O)2 NR14R15, S(O)2NR15R15, NR14S(O)2NR14R15, NR15S(O)2NR15R15, NR14S(O)2R14 or NR15S(O)2R15;

R14 is a saturated or partially or fully unsaturated 3-8 membered monocyclic, membered bicyclic, or 7-14 membered tricyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic, or 1-9 heteroatoms if tricyclic, said heteroatoms selected from O, N, or S, and wherein said ring system is optionally substituted independently with 1-5 substituents of R15;
R15 is H, halo, haloalkyl, CN, OH, NO2, NH2, oxo, acetyl, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, cyclopropyl, butyl, isobutyl, tert-butyl, cyclobutyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl, phenyl or a partially or fully saturated or unsaturated 3-8 membered monocyclic or 6-12 membered bicyclic ring system, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-6 heteroatoms if bicyclic, said heteroatoms selected from 0, N, or S, and optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, tert-butyl, cyclobutyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl;
each R16, independently, is haloalkyl, methyl, methoxyl, ethyl, ethoxyl, alkoxy-alkyl, alkylamino-alkyl, dialkylamino-alkyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, butyl, isobutyl, sec-butyl or tert-butyl;
h is 0, 1 or 2; and i is 1, 2 or 3.

12. The compound of Claim 11 wherein i is 1;
A is C1-6-alkyl, C2-6alkenyl, C2-6-alkynyl, C1-6alkyl-O-C1-3-alkyl-, C1-6-alkyl-S-C1-3-alkyl-, C1-6-alkyl-S(O)2-C1-3-alkyl-, C1-6-alkyl-NH-C1-3-alkyl, di-(C1-6-alkyl)-N-C1-3-alkyl, C2-6-alkenyl-O-C1-3-alkyl-, C2-6-alkenyl-S-C1-3-alkyl-, C2-6-alkenyl-S(O)2-C1-3-alkyl-, C2-6-alkenyl-NH-C1-3-alkyl- or C2-6-alkynyl-NH-C1-3-alkyl-, wherein the alkyl, alkenyl or alkynyl moiety of each is optionally substituted with 1-5 substituents of R9;
W is -C(=O)-;
V is -(CR2a R2a)h- wherein each R2a, independently, is H, C1-C10 alkyl or haloalkyl, and h is 1;
R2 is a C1-C4alkyl, C1-C4alkenyl, C1-C4alkynyl, C1-C10 haloalkyl or an optionally substituted ring system selected from phenyl, naphthyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, triazinyl, quinotinyl, isoquinolinyl, quinazolinyl, isoquinazolinyl, phthalazinyl, thiophenyl, furyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thiazolyl, oxazolyl, isoxazolyl, isothiazolyl, thiadiazolyl, oxadiazolyl, indolyl, isoindolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, tetrahydrofuranyl, pyrrolidinyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl;
R3 is H, haloalkyl, CN, C1-10-alkyl, C2-10-alkenyl or C2-10-alkynyl;
R4 is H, CN or C1-10-alkyl;

R5 is wherein m and X2 are as defined in claim 11;
X1 is CR12, C(=O), O, S, S(O)2 or NR12;
Z2 is a phenyl, pyridine, pyrimidine, triazine, pyridazine, pyrazine, pyridone, pyrrole, imidazole, pyrazole, triazole, thiophene, thiazole, thiadiazole, isothiazole, furan, oxazole, oxadiazole or isoxazole ring; and p is 0, 1, 2, 3, 4 or 5;
R7 is H, C1-10-alkyl or C2-10-alkenyl, each of the C1-10-alkyl, or C2-10-alkenyl optionally substituted with 1-3 substituents of R9;
R8 is a ring system selected from phenyl, pyridyl, pyrimidinyl, triazinyl, quinolinyl, tetrahydroquinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, quinazolinyl, isoquinazolinyl, thiophenyl, furyl, tetrahydrofuranyl, pyrrolyl, pyrazolyl, thieno-pyrazolyl, imidazolyl, triazolyl, tetrazolyl, thiazolyl, thiadiazolyl, benzothiazolyl, oxazolyl, oxadiazolyl, benzoxazolyl, benzoxadiazolyl, isoxazolyl, isothiazolyl, indolyl, azaindolyl, 2,3-dihydroindolyl, isoindolyl, indazolyl, benzofuranyl, benzothiophenyl, benzimidazolyl, imidazo-pyridinyl, purinyl, benzotriazolyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrrolidinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, 2,3-dihydro-1,4-benzoxazinyl, 1,3-benzodioxolyl, cyclopropyl, cyclobutyl, azetidinyl, cyclopentyl, cyclohexyl and cycloheptyl, said ring system optionally substituted independently with 1-3 substituents of R9, oxo, NR9R9, OR9, SR9, C(O)R9 or a partially or fully saturated or unsaturated 5-6 membered ring of carbon atoms optionally including 1-3 heteroatoms selected from O, N, or S, and optionally substituted independently with 1-5 substituents of R9;

R9 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-7-cycloalkyl, C4-7-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl; and R12 is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, oxo, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a saturated or partially or fully unsaturated 3-8 membered monocyclic or a 6-12 membered bicyclic, said ring system formed of carbon atoms optionally including 1-3 heteroatoms if monocyclic or 1-heteroatoms if bicyclic, said heteroatoms selected from O, N, or S, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring of said ring system is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopently, hexyl, cyclohexyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl.
13. The compound of claim 12 wherein R5 is wherein m is 0 or 1;
p is 0, 1, 2 or 3;
A1 is CH, C(=O), O or NR12;
each of A1 and A2, independently, is CR12 or N, provided that no more than one of A1 and A2 is N;
X2 is CH;
Y3 is CR12 or O; and each R12, independently, is H, halo, haloalkyl, CN, OH, NO2, NH2, acetyl, oxo, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl or a ring selected from phenyl, pyridyl, pyrimidinyl, triazinyl, thiophenyl, furyl, tetrahydrofuranyl, pyrrolyl, pyrazolyl, thieno-pyrazolyl, imidazolyl, triazolyl, tetrazolyl, thiazolyl, thiadiazolyl, oxazolyl, oxadiazolyl, isoxazolyl, isothiazolyl, oxazolinyl, isoxazolinyl, thiazolinyl, pyrrolidinyl, pyrazolinyl, morpholinyl, piperidinyl, piperazinyl, pyranyl, dioxozinyl, cyclopropyl, cyclobutyl, azetidinyl, cyclopentyl, cyclohexyl and cycloheptyl, wherein each of the C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C3-10-cycloalkyl, C4-10-cycloalkenyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-alkoxyl, C1-10-thioalkoxyl and ring is optionally substituted independently with 1-5 substituents of halo, haloalkyl, CN, NO2, NH2, OH, oxo, methyl, methoxyl, ethyl, ethoxyl, propyl, propoxyl, isopropyl, isopropoxyl, cyclopropyl, cyclopropylmethoxyl, butyl, butoxyl, isobutoxyl, tert-butoxyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, pentyl, cyclopently, hexyl, cyclohexyl, C1-10-alkylamino-, C1-10-dialkylamino-, C1-10-thioalkoxyl, benzyl or phenyl.
14. The compound of Claim 11, and pharmaceutically acceptable salts thereof, selected from:
N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-2,6,6-trimethyl-4,5,6,7-tetrahydro-1-benzofuran-4-yl)amino) propyl)acetamide;
N-((1S,2R)-3-(((4S)-2-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1-benzothien-4-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-(2-oxo-1-pyrrolidinyl)acetamide;
'N-((1S,2R)-3 -(((4S)-6-bromo-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-bromo-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)-2-(methyloxy)acetamide;
'N~1~-((1S,2R)-3-(((4S)-6-bromo-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)-N~2~,N~2~-dimethylglycinamide;
'N-((1 S,2R)-3-(((4S)-8-bromo-6-ethyl-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((1S)-3,3-dimethyl-7-(methyloxy)-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxypropyl)-2-(methyloxy)acetamide N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((1R)-3,3-dimethyl-7-(methyloxy)-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxypropyl)-2-(methyloxy)acetamide;

'N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((1S)-3,3-dimethyl-7-(methyloxy)-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxypropyl)acetamide N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((1R)-3,3-dimethyl-7-(methyloxy)-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-2,2-dimethyl-8-(4-morpholinyl)-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4R)-6-ethyl-2,2-dimethyl-8-(1-pyrrolidinyl)-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide N-((1S,2R)-3-(((4S)-6-ethyl-2,2-dimethyl-8-(1-pyrrolidinyl)-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3 -(((4S)-8-(dimethylamino)-6-ethyl-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide N-((1S,2R)-3-(((4R)-8-(dimethylamino)-6-ethyl-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-ethyl-2,2-dimethyl-8-(methylamino)-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((5S)-3,7,7-trimethyl-5,6,7,8-tetrahydro-5-quinolinyl)amino)propyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((1S)-3,3-dimethyl-7-((2-(methyloxy)ethyl)amino)-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide N-((1S,2R)-3-(((1R)-3,3-dimethyl-7-((2-(methyloxy)ethyl)amino)-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((1R)-7-(cyclopentylamino)-3,3-dimethyl-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide N-((1S,2R)-3-(((1S)-7-(cyclopentylamino)-3,3-dimethyl-4-oxo-1,2,3,4-tetrahydro-naphthalenyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((1S)-7-(2,2-dimethylpropyl)-3,3-dimethyl-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxypropyl)acetamide N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((1R)-7-(2,2-dimethylpropyl)-3,3-dimethyl-4-oxo-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-2-(2,2-dimethylpropyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1-benzothien-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'methyl ((1S,2R)-3-(((4S)-2-(2,2-dimethylpropyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1-benzothien-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamate;
'N-((1S,2R)-3-(((4R)-6-bromo-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide N-((1S,2R)-3-(((4S)-6-bromo-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4R)-6-(2,2-dimethylpropyl)-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenymethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4R)-1-acetyl-6-bromo-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide N-((1S,2R)-3-(((4S)-1-acetyl-6-bromo-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-1,2,3,4-tetrahydro-4-quinolinyl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((1S)-3,3-dimethyl-7-((3 S)-tetrahydro-3-furanyloxy)-1,2,3,4-tetrahydro-1-naphthalenyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;

'N-((1S,2R)-3-(((4S)-8-(dimethylamino)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-1-((3-(dimethylamino)-5-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4S)-8-(dimethylamino)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,4-difluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-8-(1-pyrrolidinyl)-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,4-difluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-8-(methylamino)-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-8-chloro-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-8-(dimethylamino)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxypropyl)propanamide;
N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4S)-6-(2,2-dimethylpropyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)amino)-2-hydroxypropyl)acetamide;

'N-((1 S,2R)-3-(((4S)-6-bromo-7-fluoro-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((2S,3R)-3-hydroxy-4-((S)-6-isopropoxy-2,2-spirocyclobutyl-chroman-4-ylamino)-1-phenylbutan-2-yl)acetamide; and 'N-((1S,2R)-3-(((2R,4S)-6-bromo-2-methyl-2-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide N-((1S,2R)-3-(((2S,4S)-6-bromo-2-methyl-2-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide.
15. The compound of Claim 1, and pharmaceutically acceptable salts thereof, selected from:
N-((2S,3R)-4-((S)-2,2-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)acetamide;
N-((2S,3R)-4((S)-6-ethyl-2,2-spirocyclopentylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)acetamide. TFA salt;
N-((2S,3R)-4((S)-6-ethyl-2,2-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-2-(pyridin-4-yl)acetamide. TFA salt;
N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(5-methyl-1H-pyrazol-1-yl)acetamide;
Methyl (2S,3R)-3-hydroxy-4-((S)-6-neopentyl-2,2-spirocyclobutyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-ylamino)-1-phenylbutan-2-ylcarbamate;
Ethyl (2S,3R)-4-((S)-6-ethyl-2,2-spirocyclobutyl-chroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamate;
N-((2S,3R)-4-((S)-6-ethyl-2,2-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)pent-4-ynamide;
3 -cyclopentyl-N-((2S,3R)-4-((S)-6-ethyl-2,2-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)propanamide;
N-((2S,3R)-4-((S)-6-ethyl-2,2-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)propionamide;
N-((2S,3R)-4-((S)-6-ethyl-2,2-spirocyclobutylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-2-methoxyacetamide;
2-(1,3-benzothiazol-2-yloxy)-N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro [chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;

N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(2-oxo-1,3-oxazolidin-3-yl)acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(1H-pyrrolo[2,3-b]pyridin-1-yl)acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-2-(2-oxo-1,3-oxazolidin-3-yl)acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-2-(methyloxy)acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro [chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;

N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-2-(phenyloxy)acetamide;
(3S)-N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro [chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-1-cyclobutyl-5-oxo-3-pyrrolidinecarboxamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)propanamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-2-((cyclopropylmethyl)oxy) acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((2S,4S)-6-ethyl-3,4,4',5'-tetrahydrospiro[chromene-2,3'-furan]-4-yl)amino)-2-hydroxypropyl)-2-(methyloxy) acetamide;
N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((2S,4S)-6-ethyl-3,4,4',5'-tetrahydrospiro[chromene-2,3'-furan]-4-yl)amino)-2-hydroxypropyl)acetamide;
N-((1 S,2R)-1-((3-cyanophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;

2-((3-chloro-2-methylphenyl)thio)-N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)acetamide;
N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl) acetamide;
N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro [furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl) amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)acetamide;
N-((1S,2R)-3-(((3S,4'S)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro [furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(methyloxy)acetamide;
N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-(3-methyl-5-isoxazolyl) acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-7-fluoro-3,4-dihydrospiro-2,2-spirocyclobutyl [chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(2-oxo-1-pyrrolidinyl) acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro-2,2-spirocyclobutyl [chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(2-pyrazinyloxy)acetamide;
N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro-2,2-spirocyclobutyl[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)-2-(2-pyrimidinyloxy) acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclopentan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-((5R)-2-(3-methylbutyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-5-yl) acetamide;
N-((1S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-(1H-1,2,3-triazol-4-yl) acetamide;
N-((1 S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-(4-propyl-1H-1,2,3-triazol-1-yl)acetamide;

N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4'S)-6'-ethyl-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)-2-(methyloxy)acetamide;
N-((1S,2R)-2-hydroxy-3-(((4'S)-6'-(3-methylbutyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-(phenylmethyl)propyl)-2-(methyloxy)acetamide;
N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-(2-methyl-1,3-thiazol-4-yl) acetamide;
2-(3,5-dimethyl-4-isoxazolyl)-N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-(1H-1,2,4-triazol-1-yl) acetamide;
N-((1 S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-(2H-1,2,3-triazol-2-yl) acetamide;
N-((1 S,2R)-3-(((4S)-6-chloro-8-(4-morpholinyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl) acetamide;
(E)-N-((2S,3R)-4-((S)-6-ethyl-2,2-spirocyclopentylchroman-4-ylamino)-3-hydroxy-1-phenylbutan-2-yl)-3-(pyridin-2-yl)acrylamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-((3-(2-propen-1-yl)phenyl)methyl)propyl)-6-heptenamide;
N-((1S,2R)-1-((1-acetyl-3-piperidinyl)methyl)-3-(((4S)-6-ethyl-3,4-dihydrospiro [chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-yl)acetamide;
3-(1H-benzimidazol-1-yl)-N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-methylpropanamide;

(2E)-3-(4-bromo-2-furanyl)-N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-propenamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-(1-phthalazinylthio)acetamide;
N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl) propyl)-2-(2-thienylthio)propanamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1-methyl-]1H-1,2,3-triazol-4-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-3-(((4S)-6-(1-methyl-1H-1,2,3 -triazol-4-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-(2-fluoro-2-methylpropyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-((2R)-2-fluoropropyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide N-((1S,2R)-3-(((4S)-6-((2S)-2-fluoropropyl)-3,4-dihydrospiro[chromene-2,1'-cy;
'N-((1S,2R)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
N-((1S,2R)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-8-(4-morpholinyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-1-((4-fluorophenyl)methyl)-hydroxypropyl) acetamide;
'N-((1S,2R)-3-(((4S)-6-(2,2-dimethylpropyl)-8-(4-morpholinyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S)-1-((1R)-2-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-3-methylbutyl)acetamide;
'N-((1S)-1-((1R)-2-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin}-4'-yl)amino)-1-hydroxyethyl)-3-methyl-3-buten-1-yl)acetamide;
'N-((1S,2R)-1-((3-cyanophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-2-hydroxy-3-(((5'S)-3'-methyl-5',8'-dihydro-6'H-spiro[cyclobutane-1,7'-quinolin]-5'-yl)amino)-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((5'S)-3'-methyl-5',8'-dihydro-6'H-spiro[cyclobutane-1,7'-quinolin}-5'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1,3-oxazol-2--yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclopentane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclopentane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclopentane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclopropane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluoro-3-methylphenyl)methyl)-2-hydroxypropyl)acetamide;

'N-((l S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclopent-3-ene-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1 S,2R)-3-(((4'S)-6'-((1S)-1-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide N-((1S,2R)-3-(((4'S)-6'-((1R)-1-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-((1R)-1-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-((1S)-1-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-y1)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-((1S)-1-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-((1S)-1-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydro-1'H-spiro[cyclobutane-1,2'-quinolin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydro-1'H-spiro[cyclobutane-1,2'-quinolin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydro-1'H-spiro[cyclobutane-1,2'-quinolin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-bromo-4-fluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydro-1'H-spiro[cyclobutane-1,2'-quinolin]-4'-yl)amino)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-l'-oxo-3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-naphthalen]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'R)-6'-(2,2-dimethylpropyl)-1'-oxo-3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-naphthalen]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((3S,4'S)-6'-chloro-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide N-((1S,2R)-(((3R,4'S)-6'-chloro-3',4,4',5-tetrahydrospiro [furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-ethyl-3',4-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2S)-3-(((4'S)-6-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3 -(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluoro-3-methylphenyl)methyl)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluoro-4-methylphenyl)methyl)-2-hydroxypropyl)acetamide;
'methyl((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)carbamate;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclopropane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((4-fluoro-3-methylphenyl)methyl)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((3-(methyloxy)phenyl)methyl)propyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclopropane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethyl-3-(methyloxy)propyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-8'-(dimethylamino)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-(methylamino)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4'S)-8'-chloro-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-(ethylamino)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-3-(((4'S)-6-(2,2-dimethylpropyl)-8'-((1-methylethyl)amino)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-8'-(cyclopropylamino)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-y1)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-(tetrahydro-2H-pyran-4-ylamino)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-8'-chloro-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-8'-(dimethylamino)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-8'-((1,1-dimethylethyl)amino)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-(methylamino)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-(ethylamino)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3 c]pyridin]-4'-yl)amino)-1-((3 -fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-(tetrahydro-2H-pyran-4-ylamino)-3', 4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3 -fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-8'-(dimethylamino)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-oxo-3',4',7',8'-tetrahydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;

N-((1S,2R)-3-(((4'R)-6'-(2,2-dimethylpropyl)-8'-((1-methylethyl)oxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-((1-methylethyl)oxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'R)-6'-(2,2-dimethylpropyl)-8'-((1-methylethyl)oxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-((1-methylethyl)oxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'R)-6'-(2,2-dimethylpropyl)-8'-((1-methylethyl)oxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-(((4'S)-6'-(2,2-dimethylpropyl)-8'-((1-methylethyl)oxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-8'-(dimethylamino)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4'S)-8'-(dimethylamino)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-(dimethylamino)phenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-8'-(dimethylamino)-6-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((4'S)-8'-(dimethylamino)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-8'-(cyclopropylamino)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'1,1-dimethylethyl (2-(((4'S)-4'-(((2R,3S)-3-(acetylamino)-4-(3-fluorophenyl)-hydroxybutyl)amino)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-8'-yl)amino)ethyl)carbamate;

'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-(3-(methyloxy)-1-azetidinyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-8'-amino-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-8'-((2-aminoethyl)amino)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-(methyloxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'R)-6'-(2,2-dimethylpropyl)-8'-((1-methylethyl)oxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-((1-methylethyl)oxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'R)-6'-(2,2-dimethylpropyl)-8'-((1-methylethyl)oxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-((1-methylethyl)oxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'R)-6'-(2,2-dimethylpropyl)-8'-((1-methylethyl)oxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-((1-methylethyl)oxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-6'-(2,2-dimethylpropyl)-8'-(methyloxy)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-(3-(methyloxy)-1-azetidinyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((1s,3R,4'S)-3-methyl-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((1r,3S,4'S)-3-methyl-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((1s,3R,4'S)-3-methyl-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-2-hydroxy-3-(((1s,3R,4'S)-3-methyl-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-3-(((1S,2S,4'S)-6'-(2,2-dimethylpropyl)-2-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((1S,2S,4'S)-6'-(2,2-dimethylpropyl)-2-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((1R,2R,4'S)-6'-(2,2-dimethylpropyl)-2-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((1R,2R,4'S)-6'-(2,2-dimethylpropyl)-2-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((1S,2R,4'S)-6'-(2,2-dimethylpropyl)-2-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((1S,2R,4'S)-6'-(2,2-dimethylpropyl)-2-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-3-(((1R,2S,4'S)-6'-(2,2-dimethylpropyl)-2-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((1R,2S,4'S)-6'-(2,2-dimethylpropyl)-2-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'methyl ((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3 -b]pyridin]-4'-yl)amino)-2-hydroxypropyl)carbamate;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)-(methyloxy)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)-fluoroacetamide;
N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)-2,2-difluoroacetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)-2,2,2-trifluoroacetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)-3,3,3-trifluoropropanamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)-(methyloxy)propanamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(1,3-thiazol-4-ylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(4-pyridinylmethyl)propyl)acetamide;

'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((2-propyl-1,3-thiazol-4-yl)methyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((5-propyl-1,3-thiazol-4-yl)methyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(1,3-thiazol-5-ylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((2-methyl-1,3-thiazol-4-yl)methyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((2-methyl-4-pyridinyl)methyl)propyl)acetamide;
'N-((1S,2R)-1-((4-chloro-1,3-thiazol-2-yl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((2-chloro-4-pyridinyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((2-(methyloxy)-4-pyridinyl)methyl)propyl)acetamide;
N-((1S,2R)-1-((2-chloro-6-methyl-4-pyridinyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((2-((2,2,2-trifluoroethyl)oxy)-pyridinyl)methyl)propyl)acetamide;
'N-((1R,2S)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(4-pyridinylmethyl)propyl)acetamide;

N-((1S,2R)-1-(1-benzofuran-2-ylmethyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3,4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((2-oxo-1,2-dihydro-4-pyridinyl)methyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((2-(trifluoromethyl)-4-pyrimidinyl)methyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((4-(trifluoromethyl)phenyl)methyl)propyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-(2-cyano-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((1-methyl-2-oxo-1,2-dihydro-4-pyridinyl)methyl)propyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-(3,3-difluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethyl-3-butyn-1-yl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylbutyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2-cyano-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2-cyano-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-3-(((4'S)-6'-(3,3-difluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4S)-2-ethyl-4,7-dihydro-5H-spiro[1-benzothiophene-6,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-7'-fluoro-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((3S,4'R)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((3R,4'R)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((3S,4'S)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((3R,4'S)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((3S,4'S)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide N-((1S,2R)-3-(((3R,4'S)-6'-(2,2-dimethylpropyl)-3',4,4,5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-7'-fluoro-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((3S,4'S)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide N-((1S,2R)-3-(((3R,4'S)-b'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-7'-fluoro-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-7'-fluoro-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((35,4'S)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((3R,4'S)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((3S,4'R)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((3R,4'R)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluoro-4-(methyloxy)phenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2S)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluoro-4-(methyloxy)phenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-7'-fluoro-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-hydroxypropyl)acetamide;
N-((1R,2S)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluoro-4-(trifluoromethyl)phenyl)methyl)-2-hydroxypropyl)acetamide N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluoro-(trifluoromethyl)phenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-((1R)-1-fluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide N-((1S,2R)-3-(((4'S)-6'-((1S)-1-fluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((3S,4'S)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((3R,4'S)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((35,4'S)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((3R,4'S)-6'-(2,2-dimethylpropyl)-3',4,4',5-tetrahydrospiro[furan-3,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-((1R)-1-fluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-((1S)-1-fluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro[ cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-((1S)-1-fluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-((1R)-1-fluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluoro-3-(trifluoromethyl)phenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((4'S)-6'-((1R)-1-fluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-((1R)-1-fluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-3-(((4'S)-6'-((1R)-1-fluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-((1R)-1-fluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-6'-((1R)-1-fluoro-2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(cyclobutylmethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((5R,5aS)-3-(2,2-dimethylpropyl)-5a,6,7,5-tetrahydro-5H-pyrrolo[1',2':1,5]pyrrolo[2,3-b]pyridin-5-yl)amino)-1-((4-fluorophenyl)methyl)-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(1-hydroxypentyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((2,4,5-trifluorophenyl)methyl)propyl)acetamide;
'N-((1S,2R)-3 -(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((3,4,5-trifluorophenyl)methyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(cyclopropylmethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-((1-methylcyclopropyl)methyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(3,3-difluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-y1)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-3-(((4'S)-6'-(cyclopropylmethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-((2S)-3-fluoro-2-methylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2, 3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide N-((1S,2R)-3-(((4'S)-6'-((2R)-3-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1 S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-6'-(2-ethylbutyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano [2, 3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
N-((l S,2R)-l -((4-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-propyl-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((l S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-((2S)-2-methylbutyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2, 3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((l S,2R)-3-(((4'S)-6'-butyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((l S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2-methyl-1-propen-1-yl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1 S,2R)-3-(((4S)-6'-(2,2-dimethylpropanoyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'2-azido-N-((1 S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-l-(phenylmethyl)propyl)acetamide;
N-((1 S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((4S)-6-(trifluoromethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((l S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(trifluoromethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((l S,2R)-1-((3,4-difluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;

'N-((1 S,2R)-1-((3-chlorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((2-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((2,4-difluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S)-1-((1R)-2-(((4'S)-6-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-3-pentyn-1-yl)acetamide;
'N-((1S,2R)-1-((3-chloro-4-fluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2, 3-b]pyridin] -4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b] pyridin] -4'-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((2-chlorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-(dimethylamino)-4-fluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2, 3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-(ethylamino)-4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,4-dichlorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((4-((trifluoromethyl)oxy)phenyl)methyl)propyl)acetamide;

N-((1S,2R)-1-((3-chloro-4-fluorophenyl)methyl)-3-(((1 s,3R,4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((1s,3R,4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S)-1-((1R)-2-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-4-penten-1-yl)acetamide;
'N-((1S,2R)-1-((4-chloro-3-(trifluoromethyl)phenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S)-1-((1R)-2-(((1s,3R,4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-4-penten-1-yl)acetamide;
N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((3-(trifluoromethyl)phenyl)methyl)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-(trifluoromethyl)phenyl)methyl)propyl)acetamide;
'N-((1S,2R)-1-((4-chloro-3-fluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chloro-3-(methyloxy)phenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-(cyclopropylmethyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[oyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yI)amino)-2-hydroxy-1-((2-methylcyclopropyl)methyl)propyl)acetamide;

'N-((1S,2R)-1-(cyclopropylmethyl)-3-(((4'S)-6'-(4,4-difluoro-2,2-dimethylbutyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-(cyclopropylmethyl)-3-(((1s,3R,4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((2-((difluoromethyl)oxy)-4-pyridinyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N~1~-((1S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-1-((3-cyanophenyl)methyl)-2-hydroxypropyl)-N-2-,N-2~-dimethylglycinamide;
'methyl (4S)-4-(((2R,3S)-4-(3-cyanophenyl)-3-((N,N-dimethylglycyl)amino)-2-hydroxybutyI)amino)-3,4-dihydrospiro[chromene-2,1'-cyclobutane]-6-carboxylate;

'methyl (4S)-4-(((2R,3S)-3-(acetylamino)-4-(3-cyanophenyl)-2-hydroxybutyl)amino)-3,4-dihydrospiro[chromene-2,1'-cyclobutane]-6-carboxylate;

'methyl (4S)-4-(((2R,3S)-4-(3-cyanophenyl)-2-hydroxy-3-(((methyloxy)acetyl)amino)butyl)amino)-3,4-dihydrospiro[chromene-2,1'-cyclobutane]-6-carboxylate;
'N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-((methyloxy)methyl)propyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-((propyloxy)methyl)propyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(((phenylmethyl)oxy)methyl)propyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-ethyl-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(1-(1H-pyrazol-1-ylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(1H-pyrazol-1-ylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((2-propen-1-yloxy)methyl)propyl)acetamide;

'N-((1S)-1-((1R)-2-(((4'S)-6'-(2,2-dimethylpropyl)-3,4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-3-buten-1-yl)acetamide;
'N-((1S)-1-((1S)-2-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-3-buten-1-yl)acetamide;
'N-((1S)-1-((1 R)-2-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-4,4,4-trifluorobutyl)acetamide;
'N-((1S,3E)-1-((1R)-2-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-3-penten-1-yl)acetamide;
'N-((1S)-1-((1R)-2-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1, 2'-pyrano[2, 3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-2 -propen-1-yl)acetamide;
'N-((1S)-1-((1R)-2-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano [2, 3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-3-buten-1-yl)acetamide;
'N-((1S)-1-((1R)-2-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-3-hexyn-1-yl)acetamide;
'N-((1S,2R)-3-(((2S,4 S)-6-chloro-8-(4-morpholinyl)-3,4,4',5'-tetrahydrospiro [chromene-2,3'-furan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide N-((1S,2R)-3-(((2R,4S)-6-chloro-8-(4-morpholinyl)-3,4,4',5'-tetrahydrospiro[chromene-2,3'-furan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S, 2R)-3-(((4S)-6-(2,2-dimethylpropyl)-3,4-dihydrospiro [chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-2-(1H-2-methyl-imidazol-1-yl) acetamide;
'N-((1S,2R)-3-(((4'S)-6'-bromo-3',4-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(1H-pyrazol-1-yl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;

'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(1H-imidazol-1-yl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(1,3-thiazol-2-yl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl) amino)propyl)acetamide;
N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3 -c]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl) acetamide;
'N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-c]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2-hydroxy-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-c]
pyridin]-4'-yl)amino)propyl)acetamide;
N-((1S,2R)-3-(((4'S)-8'-chloro-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-chloro-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3 -(((4'S)-8'-chloro-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((5'S)-3'-(2,2-dimethylpropyl)-5',6'-dihydrospiro [cyclobutane-1,7'-pyrano[2,3-c]pyridazin]-5'-yl)amino)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-(4-morpholinyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-8'-(1-pyrrolidinyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((3-(dimethylamino)-5-fluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl) acetamide;

'N-((1S,2R)-1-((3-bromo-5-fluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide N-((1S,2R)-3-(((1 s,3R,4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((1s,3R,4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((1s,3R,4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((1r,3S,4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((1s,3R,4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((1s,3R,4'S)-6'-(2,2-dimethylpropyl)-3-methyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((1s,3S,4'S)-6'-(2,2-dimethylpropyl)-3-hydroxy-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2, 3-b]pyridin]-4'-y1)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-(cyclopentylamino)-3,4-dihydrospiro[chromene-2,1 cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;

'N-((1S,2R)-3-(((4S)-6-((1,1-dimethylethyl)amino)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-chloro-8-(1H-imidazol-1-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-3-(((4S)-6-bromo-3,4-dihydro spiro [chromene-2,1'-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-8-(1H-benzimidazol-1-yl)-6-chloro-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-chloro-8-(1H-pyrazol-1-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1H-pyrazol-1-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-(2-thienyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-3-(((4S)-6-(1-(2-methylpropyl)-1H-pyrazol-3-yl)-3,4-dihydrospiro [chromene-2,1'-cyclobutan] -4-yl)amino)-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1-(2-methylpropyl)-1H-pyrazol-3-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2S)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1H-pyrazol-1-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1H-imidazol-1-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-3-(((4S)-6-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(2-thienyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;

'N-((1S,2S)-3-(((4S)-6-chloro-8-(1H-pyrazol-1-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4S)-7-bromo-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-7-(1H-imidazol-1-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
N-((4S)-4-(((2R,3 S)-3-(acetylamino)-4-(3,5-difluorophenyl)-2-hydroxybutyl)amino)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-6-yl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-((3R)-tetrahydro-3-furanylamino)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(2H-1,2,3-triazol-2-yl)-3,4-dihydrospiro [chromene-2,1'-cyclobutan]-4-y1) amino)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(1H-1,2,4-triazol-1-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(2-oxo-1-pyrrolidinyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4S)-6-(2-oxo-1-azetidinyl)-3,4-dihydrospiro [chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-3-(((4S)-6-bromo-7-fluoro-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-1-((3,5-difluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4S)-7-fluoro-6-((3R)-tetrahydro-3-furanylamino)-3,4-dihydrospiro [chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4S)-7-fluoro-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3 -b]pyridin]-4'-yl)amino)-1-((3 -fluoro-5-(tetrahydro-2H-pyran-4-ylamino)phenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4S)-7-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)-3,4-dihydrospiro [chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-1-((3-fluorophenyl)methyl)-3-(((4S)-7-fluoro-6-(1H-pyrazo-1-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-fluorophenyl)methyl)-3-(((4S)-7-fluoro-6-(1H-pyrazol-1-yl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S, 2R)-1-(cyclobutylmethyl)-3 -(((4'S)-6'-(2, 2 -dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((2-bromophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4'S)-6'-((1R)-1-fluoro-2,2-dimethylpropyl)-3',4'-dihydro spiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(1-azatricyclo[6.2.2.0-2,7-]dodeca-2,4,6-trien-8-ylamino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1 S,2R)-3-(((2R,4S)-1'-acetyl-6-ethyl-3,4-dihydrospiro[chromene-2,3'-pyrrolidin]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide N-((1S,2R)-3-(((2S,4S)-1'-acetyl-6-ethyl-3,4-dihydrospiro[chromene-2,3'-pyrrolidin]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((2,4,6-trifluorophenyl)methyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-l-((2,3,4-trifluorophenyl)methyl)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((2,4,6-trifluorophenyl)methyl)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((2,3,4-trifluorophenyl)methyl)propyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclopentane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(phenylmethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-y1)amino)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-((2R)-tetrahydro-2-furanyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide N-((l S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-((2S)-tetrahydro-2-furanyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4'S)-6'-((2S)-tetrahydro-2-furanylmethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide N-((1 S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4'S)-6'-((2R)-tetrahydro-2-furanylmethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b] pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4'S)-6'-((2R)-tetrahydro-2-furanylmethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)-2-(methyloxy)acetamide N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4'S)-6'-((2S)-tetrahydro-2-furanylmethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)-2-(methyloxy)acetamide;
'N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-((2S)-tetrahydro-2-furanylmethyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-((2R)-tetrahydro-2-furanylmethyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-3-(((4S)-6-(5-hydroxypentyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-3-(((4'S)-6'-(((2S)-2-methyltetrahydro-2-furanyl)methyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-(phenylmethyl)propyl)acetamide N-((1 S,2R)-2-hydroxy-3-(((4'S)-6'-(((2R)-2-methyltetrahydro-2-furanyl)methyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2, 3-b]pyridin]-4'-yl)amino)-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(3-pyridinylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;

N-((1S,2R)-1-((2,6-difluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1 S,2R)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((1-methyl-3-piperidinyl)methyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((5-fluoro-3-pyridinyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2S)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((5-fluoro-3-pyridinyl)methyl)-2-hydroxypropyl)acetamide;
N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-((trimethylsilyl)methyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3,4-bis(methyloxy)phenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-((trimethylsilyl)methyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-((trimethylsilyl)methyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b] pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-1-((3-bromo-4-fluorophenyl)methyl)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-chloro-4-fluorophenyl)methyl)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((3-(trifluoromethyl)phenyl)methyl)propyl)acetamide;
'N-((1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-(1,3-benzodioxol-5-ylmethyl)-3-(((4'S)-6'-(2-fluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-(2,2,2-trifluoroethyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4S)-6-(2-pyridinyl)-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4'S)-6'-(2,2,2-trifluoroethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3,4-difluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2,2,2-trifluoroethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2,2,2-trifluoroethyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;

N-((1S,2R)-3-(((4'S)-6'-bromo-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-l -((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b] pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3-chloro-5-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'3-((2S,3R)-2-(acetylamino)-3-hydroxy-4-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)butyl)benzamide;
'N-((1S,2R)-1-((3-cyanophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3,4-difluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-7'-fluoro-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide;
'N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-7'-fluoro-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-7'-fluoro-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((4-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-7'-fluoro-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-((3-fluorophenyl)methyl)-2-hydroxypropyl)acetamide;

'N-((1S,2R)-1-((2,3-difluorophenyl)methyl)-3-(((4'S)-7'-fluoro-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((l S,2R)-1-((4-chloro-3-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(1,3,3,3-tetrafluoro-2-methylpropyl)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(1,3,3,3-tetrafluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(1,3,3,3-tetrafluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4'S)-6'-(1,3,3,3-tetrafluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(3,3,3-trifluoro-hydroxy-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3 -b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(3,3,3-trifluoro-hydroxy-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((4'S)-6'-(3,3,3-trifluoro-1-hydroxy-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'N-((1S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-((2R)-3,3,3-trifluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide N-((1 S,2R)-1-((3-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-((2S)-3,3,3 -trifluoro-2-methylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2,3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'ethyl 1-(2-(((1 S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)amino)-2-oxoethyl)-1 H-1,2,3-triazole-4-carboxylate;
'N-((1S,2R)-1-((3-bromo-4-fluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano [2, 3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'2-(5-(aminomethyl)-1H-1,2,3-triazol-1-yl)-N-((1S,2R)-3-(((4S)-6-bromo-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)acetamide 2-(4-(aminomethyl)-1H-1,2,3-triazol-1-yl)-N-((1S,2R)-3-(((4S)-6-;
'N-((1R,2R)-1-((3-chloro-2-fluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((5-chloro-2-fluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-chloro-2-fluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-chloro-2,4-difluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3 -b] pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((3-chloro-4,5-difluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((2,3,6-trifluorophenyl)methyl)propyl)acetamide;
'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-((2,3,5-trifluorophenyl )methyl)propyl)acetamide;

'N-((1S,2R)-1-((4-bromophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'N-((1S,2R)-1-((4-chlorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-((1-methylethyl)oxy)-3',4'-dihydrospiro [cyclobutane-1,2'-pyrano [2, 3-b]pyridin]-4'-yl)amino)propyl)acetamide;
'methyl((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamate;
N-((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-6'-ethyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)acetamide;
'methyl ((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-6'-ethyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)carbamate;
'methyl((1S,2R)-1-((3,5-difluorophenyl)methyl)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-2-hydroxypropyl)carbamate; and 'N-((1S,2R)-3-(((4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-c]pyridin]-4'-yl)amino)-2-hydroxy-1-(phenylmethyl)propyl)propanamide;
'N-((1S,2R)-1-((4-fluorophenyl)methyl)-2-hydroxy-3-(((4'S)-6'-(3-hydroxy-2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)propyl)acetamide.
16. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to Claim 1.
17. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to Claim 10.
18. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to Claim 11.
19. Use of the compound according to any of claims 1-10 and 15 for the preparation of a medicament for the treatment of a disorder related to the activity of beta-secretase in a subject.
20. Use of the compound according to any of claims 11-14 for the preparation of a medicament for the treatment of a disorder related to the activity of beta-secretase in a subject.
21. Use of the compound according to any of claims 1-10 and 15 for the preparation of a medicament for the treatment of Alzheimer's disease in a subject.
22. Use of the compound according to any of claims 11-14 for the preparation of a medicament for the treatment of Alzheimer's disease in a subject.
23. Use of the compound according to any of claims 1-10 and 15 for the preparation of a medicament for the reduction of the formation of beta amyloid peptide in a subject.
24. Use of the compound according to any of claims 11-14 for the preparation of a medicament for the reduction of the formation of beta amyloid peptide in a subject.
25. Use of the compound according to any of claims 1-10 and 15 for the preparation of a medicament for the reduction of plaque on the brain of a subject.
26. Use of the compound according to any of claims 11-14 for the preparation of a medicament for the reduction of plaque on the brain of a subject.
27. Use of the compound according to any of claims 1-10 and 15 for the preparation of a medicament for the treatment of mild cognitive impairment, Down's syndrome, Hereditary cerebral hemorrhage with dutch-type amyloidosis, cerebral amyloid angiopathy, degenerative dementia, dementia associated with Parkinson's disease, dementia associated with supranuclear palsy, dementia associated with cortical basal degeneration, diffuse lewy body type of Alzheimer's disease or a combination thereof in a subject.
28. Use of the compound according to any of claims 11-14 for the preparation of a medicament for the treatment of mild cognitive impairment, Down's syndrome, Hereditary cerebral hemorrhage with dutch-type amyloidosis, cerebral amyloid angiopathy, degenerative dementia, dementia associated with Parkinson's disease, dementia associated with supranuclear palsy, dementia associated with cortical basal degeneration, diffuse lewy body type of Alzheimer's disease or a combination thereof in a subject.
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