CA2610436A1 - Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders - Google Patents

Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders Download PDF

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Publication number
CA2610436A1
CA2610436A1 CA002610436A CA2610436A CA2610436A1 CA 2610436 A1 CA2610436 A1 CA 2610436A1 CA 002610436 A CA002610436 A CA 002610436A CA 2610436 A CA2610436 A CA 2610436A CA 2610436 A1 CA2610436 A1 CA 2610436A1
Authority
CA
Canada
Prior art keywords
hexahydroazepine
pyrrolidine
piperidine
treatment
carboxamide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002610436A
Other languages
French (fr)
Other versions
CA2610436C (en
Inventor
Michael J. Costanzo
William J. Hoekstra
Bruce E. Maryanoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho-Mcneil Pharmaceutical, Inc.
Michael J. Costanzo
William J. Hoekstra
Bruce E. Maryanoff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical, Inc., Michael J. Costanzo, William J. Hoekstra, Bruce E. Maryanoff filed Critical Ortho-Mcneil Pharmaceutical, Inc.
Priority claimed from CA002258701A external-priority patent/CA2258701C/en
Publication of CA2610436A1 publication Critical patent/CA2610436A1/en
Application granted granted Critical
Publication of CA2610436C publication Critical patent/CA2610436C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Abstract

Carboxamide derivatives of pyrrolidine, piperidine, and hexahydroazepine of formula (I) are disclosed as useful in treating platelet-mediated thrombotic disorders.

Claims (3)

1. A process for preparing a compound of the formula comprising treating a compound of the formula AG3 with penicillin amidase.
2. The process of claim 1, wherein the compound of the formula AG3 was placed in a water solution and the pH was adjusted to about 7.5 prior to treatment with penicillin amidase.
3. A compound of the formula AG4:

CA2610436A 1996-05-01 1997-04-29 Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders Expired - Lifetime CA2610436C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1667596P 1996-05-01 1996-05-01
US60/016,675 1996-05-01
CA002258701A CA2258701C (en) 1996-05-01 1997-04-29 Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002258701A Division CA2258701C (en) 1996-05-01 1997-04-29 Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders

Publications (2)

Publication Number Publication Date
CA2610436A1 true CA2610436A1 (en) 1997-11-06
CA2610436C CA2610436C (en) 2011-01-25

Family

ID=39182069

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2610436A Expired - Lifetime CA2610436C (en) 1996-05-01 1997-04-29 Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders

Country Status (1)

Country Link
CA (1) CA2610436C (en)

Also Published As

Publication number Publication date
CA2610436C (en) 2011-01-25

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