CA2607176A1 - Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents - Google Patents
Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents Download PDFInfo
- Publication number
- CA2607176A1 CA2607176A1 CA002607176A CA2607176A CA2607176A1 CA 2607176 A1 CA2607176 A1 CA 2607176A1 CA 002607176 A CA002607176 A CA 002607176A CA 2607176 A CA2607176 A CA 2607176A CA 2607176 A1 CA2607176 A1 CA 2607176A1
- Authority
- CA
- Canada
- Prior art keywords
- als
- candida
- mice
- albicans
- vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract 17
- 206010042938 Systemic candida Diseases 0.000 title claims abstract 5
- 201000003984 candidiasis Diseases 0.000 title claims abstract 5
- 208000019164 disseminated candidiasis Diseases 0.000 title claims abstract 5
- 239000012678 infectious agent Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000012634 fragment Substances 0.000 claims abstract 14
- 230000002163 immunogen Effects 0.000 claims abstract 10
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims abstract 9
- 230000021164 cell adhesion Effects 0.000 claims abstract 8
- 230000000694 effects Effects 0.000 claims abstract 8
- 229960005486 vaccine Drugs 0.000 claims abstract 8
- 241000222122 Candida albicans Species 0.000 claims abstract 4
- 241000222178 Candida tropicalis Species 0.000 claims abstract 4
- 241000235645 Pichia kudriavzevii Species 0.000 claims abstract 4
- 241000222126 [Candida] glabrata Species 0.000 claims abstract 4
- 229940095731 candida albicans Drugs 0.000 claims abstract 4
- 208000032343 candida glabrata infection Diseases 0.000 claims abstract 4
- 206010041925 Staphylococcal infections Diseases 0.000 claims abstract 3
- 239000002671 adjuvant Substances 0.000 claims abstract 2
- 230000009545 invasion Effects 0.000 claims abstract 2
- 102000004169 proteins and genes Human genes 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 3
- 210000004897 n-terminal region Anatomy 0.000 claims 3
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 238000002649 immunization Methods 0.000 claims 2
- 208000015339 staphylococcus aureus infection Diseases 0.000 claims 2
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 108010085895 Laminin Proteins 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 241000222173 Candida parapsilosis Species 0.000 abstract 1
- 206010028080 Mucocutaneous candidiasis Diseases 0.000 abstract 1
- 229940055022 candida parapsilosis Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/14—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from fungi, algea or lichens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/123,873 US20060083750A1 (en) | 1999-11-19 | 2005-05-05 | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis |
| US11/123,873 | 2005-05-05 | ||
| PCT/US2006/017482 WO2006121895A2 (en) | 2005-05-05 | 2006-05-04 | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2607176A1 true CA2607176A1 (en) | 2006-11-16 |
Family
ID=37397150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002607176A Abandoned CA2607176A1 (en) | 2005-05-05 | 2006-05-04 | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060083750A1 (enExample) |
| EP (1) | EP1883421A4 (enExample) |
| JP (1) | JP2008540453A (enExample) |
| AU (1) | AU2006244401B2 (enExample) |
| CA (1) | CA2607176A1 (enExample) |
| WO (1) | WO2006121895A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070077256A1 (en) * | 1999-11-19 | 2007-04-05 | Los Angeles Biomedical Research Institute | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
| RU2015122387A (ru) * | 2009-07-03 | 2015-10-27 | Лос-Анжелес Биомедикал Ресёрч Институт Эт Харбор-Укла Медикал Центер | Hyr1 в качестве мишени для активной и пассивной иммунизации против candida |
| CA2871081A1 (en) * | 2011-04-21 | 2012-10-26 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Peptide and conjugate vaccines for fungal infections |
| CN103998056B (zh) * | 2011-07-22 | 2017-09-12 | 诺瓦蒂格姆疗法有限公司 | 用于接种抗金黄色葡萄球菌疫苗的方法和组合物 |
| EA030005B1 (ru) | 2013-03-15 | 2018-06-29 | Лос-Анджелес Биомедикал Ресерч Институт Эт Харбор-Укла Медикал Центер | Композиции и способы лечения грибковых и бактериальных патогенов |
| CN108883167A (zh) | 2016-03-09 | 2018-11-23 | 加州大学洛杉矶分校港口医学中心生物医学研究所 | 用于预防和治疗外阴阴道念珠菌病的方法和药剂盒 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5668263A (en) * | 1994-12-16 | 1997-09-16 | Smithkline Beecham Corporation | Conserved yeast nucleic acid sequences |
| US5858378A (en) * | 1996-05-02 | 1999-01-12 | Galagen, Inc. | Pharmaceutical composition comprising cryptosporidium parvum oocysts antigen and whole cell candida species antigen |
| US6747137B1 (en) * | 1998-02-13 | 2004-06-08 | Genome Therapeutics Corporation | Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics |
| US7067138B1 (en) * | 1999-11-19 | 2006-06-27 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis |
| US20070077256A1 (en) * | 1999-11-19 | 2007-04-05 | Los Angeles Biomedical Research Institute | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
| US8541008B2 (en) * | 1999-11-19 | 2013-09-24 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Pharmaceutical compositions and methods to vaccinate against candidiasis |
| CA2325774C (en) * | 1999-12-10 | 2011-02-08 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food | Coniothyrium minitans .beta.-(1,3) exoglucanase gene cbeg1 |
| US7241613B1 (en) * | 2002-06-05 | 2007-07-10 | Oscient Pharmaceuticals Corporation | Identification of Candida cell surface proteins and their uses |
| UA109105C2 (uk) * | 2006-04-17 | 2015-07-27 | Молекула нуклеїнової кислоти, що кодує істотно нетоксичний мутеїн альфа-токсину clostridium perfringens, та істотно нетоксичний мутеїн альфа-токсину clostridium perfringens |
-
2005
- 2005-05-05 US US11/123,873 patent/US20060083750A1/en not_active Abandoned
-
2006
- 2006-05-04 EP EP06752341A patent/EP1883421A4/en not_active Withdrawn
- 2006-05-04 WO PCT/US2006/017482 patent/WO2006121895A2/en not_active Ceased
- 2006-05-04 AU AU2006244401A patent/AU2006244401B2/en not_active Ceased
- 2006-05-04 CA CA002607176A patent/CA2607176A1/en not_active Abandoned
- 2006-05-04 JP JP2008510281A patent/JP2008540453A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006121895A2 (en) | 2006-11-16 |
| AU2006244401A1 (en) | 2006-11-16 |
| JP2008540453A (ja) | 2008-11-20 |
| EP1883421A2 (en) | 2008-02-06 |
| US20060083750A1 (en) | 2006-04-20 |
| AU2006244401A8 (en) | 2006-11-16 |
| EP1883421A4 (en) | 2009-12-16 |
| WO2006121895A3 (en) | 2007-06-07 |
| AU2006244401B2 (en) | 2012-09-06 |
Similar Documents
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| US10300120B2 (en) | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents | |
| US20140127217A1 (en) | Pharmaceutical compositions and methods to vaccinate against candidiasis | |
| Sui et al. | The vaccines and antibodies associated with Als3p for treatment of Candida albicans infections | |
| EP2448959B1 (en) | Hyr1 as a target for active and passive immunization against candida | |
| AU2006244401B2 (en) | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents | |
| US7067138B1 (en) | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis | |
| AU2012216520A1 (en) | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents | |
| AU2013203750A1 (en) | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents | |
| Chandley et al. | Role of Vaccines and Monoclonal Antibodies in Systemic Candidiasis: Past and Future Approaches |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20170529 |