CA2598381A1 - Replikin peptides and uses thereof - Google Patents
Replikin peptides and uses thereof Download PDFInfo
- Publication number
- CA2598381A1 CA2598381A1 CA002598381A CA2598381A CA2598381A1 CA 2598381 A1 CA2598381 A1 CA 2598381A1 CA 002598381 A CA002598381 A CA 002598381A CA 2598381 A CA2598381 A CA 2598381A CA 2598381 A1 CA2598381 A1 CA 2598381A1
- Authority
- CA
- Canada
- Prior art keywords
- replikin
- lysine
- virus
- peptide
- replikins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 248
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 88
- 238000000034 method Methods 0.000 claims abstract description 150
- 229960005486 vaccine Drugs 0.000 claims abstract description 98
- 235000001014 amino acid Nutrition 0.000 claims description 291
- 150000001413 amino acids Chemical class 0.000 claims description 276
- 108090000623 proteins and genes Proteins 0.000 claims description 254
- 102000004169 proteins and genes Human genes 0.000 claims description 244
- 235000018102 proteins Nutrition 0.000 claims description 242
- 241000700605 Viruses Species 0.000 claims description 155
- 206010022000 influenza Diseases 0.000 claims description 154
- 241000712461 unidentified influenza virus Species 0.000 claims description 132
- 235000018977 lysine Nutrition 0.000 claims description 129
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 121
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 109
- 239000004472 Lysine Substances 0.000 claims description 106
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 80
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 63
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims description 59
- 230000001225 therapeutic effect Effects 0.000 claims description 30
- 230000003449 preventive effect Effects 0.000 claims description 28
- 150000002669 lysines Chemical class 0.000 claims description 23
- 238000004519 manufacturing process Methods 0.000 claims description 20
- 239000002671 adjuvant Substances 0.000 claims description 17
- 239000003937 drug carrier Substances 0.000 claims description 17
- 210000000987 immune system Anatomy 0.000 claims description 15
- -1 lysine amino acids Chemical class 0.000 claims description 12
- 230000004936 stimulating effect Effects 0.000 claims description 7
- 230000002194 synthesizing effect Effects 0.000 claims description 4
- 230000010076 replication Effects 0.000 abstract description 78
- 241000282414 Homo sapiens Species 0.000 abstract description 34
- 201000010099 disease Diseases 0.000 abstract description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 16
- 230000003612 virological effect Effects 0.000 abstract description 16
- 239000003814 drug Substances 0.000 abstract description 5
- 125000003275 alpha amino acid group Chemical group 0.000 description 109
- 101150108812 proC gene Proteins 0.000 description 109
- 210000004027 cell Anatomy 0.000 description 62
- 235000014304 histidine Nutrition 0.000 description 52
- 206010028980 Neoplasm Diseases 0.000 description 50
- JLYXXMFPNIAWKQ-UHFFFAOYSA-N γ Benzene hexachloride Chemical compound ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl JLYXXMFPNIAWKQ-UHFFFAOYSA-N 0.000 description 47
- 101710154606 Hemagglutinin Proteins 0.000 description 42
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 42
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 42
- 101710176177 Protein A56 Proteins 0.000 description 42
- 238000006467 substitution reaction Methods 0.000 description 42
- 201000011510 cancer Diseases 0.000 description 41
- 239000000203 mixture Substances 0.000 description 37
- 241000272814 Anser sp. Species 0.000 description 33
- 208000032612 Glial tumor Diseases 0.000 description 32
- 206010018338 Glioma Diseases 0.000 description 32
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 description 32
- 125000000539 amino acid group Chemical group 0.000 description 30
- 241000711573 Coronaviridae Species 0.000 description 29
- 239000000185 hemagglutinin Substances 0.000 description 29
- 241000725303 Human immunodeficiency virus Species 0.000 description 28
- 238000004458 analytical method Methods 0.000 description 28
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical group OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 25
- 108090001074 Nucleocapsid Proteins Proteins 0.000 description 24
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 24
- 229960003971 influenza vaccine Drugs 0.000 description 22
- 230000006870 function Effects 0.000 description 21
- 239000000243 solution Substances 0.000 description 21
- 238000012360 testing method Methods 0.000 description 21
- 206010064097 avian influenza Diseases 0.000 description 20
- 208000037798 influenza B Diseases 0.000 description 20
- 230000008859 change Effects 0.000 description 19
- 150000007523 nucleic acids Chemical class 0.000 description 19
- 241000283973 Oryctolagus cuniculus Species 0.000 description 18
- 108010031052 malignin Proteins 0.000 description 18
- 101100151951 Homo sapiens SARS1 gene Proteins 0.000 description 17
- 241000894006 Bacteria Species 0.000 description 16
- 241000195493 Cryptophyta Species 0.000 description 16
- 230000000694 effects Effects 0.000 description 16
- 201000004792 malaria Diseases 0.000 description 16
- 102000039446 nucleic acids Human genes 0.000 description 16
- 108020004707 nucleic acids Proteins 0.000 description 16
- 239000002773 nucleotide Substances 0.000 description 16
- 125000003729 nucleotide group Chemical group 0.000 description 16
- 238000011282 treatment Methods 0.000 description 16
- 241000315672 SARS coronavirus Species 0.000 description 15
- 239000012634 fragment Substances 0.000 description 15
- 230000014509 gene expression Effects 0.000 description 15
- 241000193738 Bacillus anthracis Species 0.000 description 14
- 230000007423 decrease Effects 0.000 description 14
- 230000028993 immune response Effects 0.000 description 14
- 230000000670 limiting effect Effects 0.000 description 14
- 230000004083 survival effect Effects 0.000 description 14
- 241000271566 Aves Species 0.000 description 13
- 241001465754 Metazoa Species 0.000 description 13
- 102000036639 antigens Human genes 0.000 description 13
- 108091007433 antigens Proteins 0.000 description 13
- 230000027455 binding Effects 0.000 description 13
- 229940023041 peptide vaccine Drugs 0.000 description 13
- 230000004044 response Effects 0.000 description 13
- 101150093954 Nrep gene Proteins 0.000 description 12
- 241000700647 Variola virus Species 0.000 description 12
- 239000000427 antigen Substances 0.000 description 12
- 238000001514 detection method Methods 0.000 description 12
- 239000000284 extract Substances 0.000 description 12
- 230000008569 process Effects 0.000 description 12
- 210000002966 serum Anatomy 0.000 description 12
- 230000001131 transforming effect Effects 0.000 description 12
- 241000196324 Embryophyta Species 0.000 description 11
- 230000000692 anti-sense effect Effects 0.000 description 11
- 238000011161 development Methods 0.000 description 11
- 108020004999 messenger RNA Proteins 0.000 description 11
- 238000011160 research Methods 0.000 description 11
- 101710198474 Spike protein Proteins 0.000 description 10
- 230000000295 complement effect Effects 0.000 description 10
- 208000015181 infectious disease Diseases 0.000 description 10
- 230000015654 memory Effects 0.000 description 10
- 241000238557 Decapoda Species 0.000 description 9
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 9
- 108700001237 Nucleic Acid-Based Vaccines Proteins 0.000 description 9
- 241000318927 Shrimp white spot syndrome virus Species 0.000 description 9
- 241000209140 Triticum Species 0.000 description 9
- 230000005875 antibody response Effects 0.000 description 9
- 229940065181 bacillus anthracis Drugs 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 9
- 230000007062 hydrolysis Effects 0.000 description 9
- 238000006460 hydrolysis reaction Methods 0.000 description 9
- 230000036039 immunity Effects 0.000 description 9
- 230000035772 mutation Effects 0.000 description 9
- 230000001717 pathogenic effect Effects 0.000 description 9
- 241000894007 species Species 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 108020004705 Codon Proteins 0.000 description 8
- 108010070875 Human Immunodeficiency Virus tat Gene Products Proteins 0.000 description 8
- 241000223960 Plasmodium falciparum Species 0.000 description 8
- 101710149951 Protein Tat Proteins 0.000 description 8
- 230000000890 antigenic effect Effects 0.000 description 8
- 238000002869 basic local alignment search tool Methods 0.000 description 8
- 238000010790 dilution Methods 0.000 description 8
- 239000012895 dilution Substances 0.000 description 8
- 229940126577 synthetic vaccine Drugs 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 108700002099 Coronavirus Nucleocapsid Proteins Proteins 0.000 description 7
- 238000002965 ELISA Methods 0.000 description 7
- 241000233866 Fungi Species 0.000 description 7
- 229940096437 Protein S Drugs 0.000 description 7
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 7
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 7
- 241001135990 Tomato leaf curl virus Species 0.000 description 7
- 235000021307 Triticum Nutrition 0.000 description 7
- 235000014633 carbohydrates Nutrition 0.000 description 7
- 150000001720 carbohydrates Chemical class 0.000 description 7
- 231100000433 cytotoxic Toxicity 0.000 description 7
- 230000001472 cytotoxic effect Effects 0.000 description 7
- 239000012153 distilled water Substances 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 7
- 150000002632 lipids Chemical class 0.000 description 7
- 230000003211 malignant effect Effects 0.000 description 7
- 229910000162 sodium phosphate Inorganic materials 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 101710091045 Envelope protein Proteins 0.000 description 6
- 241000287828 Gallus gallus Species 0.000 description 6
- 229940124873 Influenza virus vaccine Drugs 0.000 description 6
- 102100034349 Integrase Human genes 0.000 description 6
- 108010006232 Neuraminidase Proteins 0.000 description 6
- 101710188315 Protein X Proteins 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 238000004422 calculation algorithm Methods 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 235000013330 chicken meat Nutrition 0.000 description 6
- 150000002411 histidines Chemical group 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 6
- 208000032839 leukemia Diseases 0.000 description 6
- 230000036210 malignancy Effects 0.000 description 6
- 235000019799 monosodium phosphate Nutrition 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 238000013515 script Methods 0.000 description 6
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 6
- 229910052717 sulfur Inorganic materials 0.000 description 6
- 238000003786 synthesis reaction Methods 0.000 description 6
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
- 206010006187 Breast cancer Diseases 0.000 description 5
- 208000026310 Breast neoplasm Diseases 0.000 description 5
- 108020004414 DNA Proteins 0.000 description 5
- 102000005348 Neuraminidase Human genes 0.000 description 5
- 101710151532 Replicating protein Proteins 0.000 description 5
- 208000001203 Smallpox Diseases 0.000 description 5
- 241000870995 Variola Species 0.000 description 5
- 206010006451 bronchitis Diseases 0.000 description 5
- 230000002596 correlated effect Effects 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 230000008034 disappearance Effects 0.000 description 5
- 208000005017 glioblastoma Diseases 0.000 description 5
- 238000004949 mass spectrometry Methods 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 244000052769 pathogen Species 0.000 description 5
- 239000002243 precursor Substances 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- 230000001018 virulence Effects 0.000 description 5
- 102000014914 Carrier Proteins Human genes 0.000 description 4
- 208000031886 HIV Infections Diseases 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 4
- 108010052285 Membrane Proteins Proteins 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 102000018478 Ubiquitin-Activating Enzymes Human genes 0.000 description 4
- 108010091546 Ubiquitin-Activating Enzymes Proteins 0.000 description 4
- 241000696962 White spot syndrome virus Species 0.000 description 4
- 235000004279 alanine Nutrition 0.000 description 4
- 108091008324 binding proteins Proteins 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000004590 computer program Methods 0.000 description 4
- 238000009833 condensation Methods 0.000 description 4
- 230000005494 condensation Effects 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 208000037797 influenza A Diseases 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 239000008363 phosphate buffer Substances 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 230000003362 replicative effect Effects 0.000 description 4
- 238000012163 sequencing technique Methods 0.000 description 4
- 238000002255 vaccination Methods 0.000 description 4
- 230000000007 visual effect Effects 0.000 description 4
- 241000224489 Amoeba Species 0.000 description 3
- 241000219195 Arabidopsis thaliana Species 0.000 description 3
- 108091033380 Coding strand Proteins 0.000 description 3
- 206010009944 Colon cancer Diseases 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 201000010915 Glioblastoma multiforme Diseases 0.000 description 3
- 208000037357 HIV infectious disease Diseases 0.000 description 3
- 208000005176 Hepatitis C Diseases 0.000 description 3
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 3
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 3
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 3
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 3
- 241000702489 Maize streak virus Species 0.000 description 3
- 102000018697 Membrane Proteins Human genes 0.000 description 3
- 101001026869 Mus musculus F-box/LRR-repeat protein 3 Proteins 0.000 description 3
- 241000237988 Patellidae Species 0.000 description 3
- 241001505332 Polyomavirus sp. Species 0.000 description 3
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 3
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 3
- 241000714474 Rous sarcoma virus Species 0.000 description 3
- 240000003768 Solanum lycopersicum Species 0.000 description 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 3
- 239000004473 Threonine Substances 0.000 description 3
- 108091023040 Transcription factor Proteins 0.000 description 3
- 102000040945 Transcription factor Human genes 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000003443 antiviral agent Substances 0.000 description 3
- 230000003416 augmentation Effects 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 210000004899 c-terminal region Anatomy 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 238000010367 cloning Methods 0.000 description 3
- 210000001072 colon Anatomy 0.000 description 3
- 208000029742 colonic neoplasm Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 108060003552 hemocyanin Proteins 0.000 description 3
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 3
- 210000004408 hybridoma Anatomy 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 230000016784 immunoglobulin production Effects 0.000 description 3
- 230000002458 infectious effect Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 201000001441 melanoma Diseases 0.000 description 3
- 238000001823 molecular biology technique Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 229940023146 nucleic acid vaccine Drugs 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 230000007918 pathogenicity Effects 0.000 description 3
- 238000010926 purge Methods 0.000 description 3
- 238000004445 quantitative analysis Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 208000000587 small cell lung carcinoma Diseases 0.000 description 3
- 201000010740 swine influenza Diseases 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 241001529453 unidentified herpesvirus Species 0.000 description 3
- 108091006112 ATPases Proteins 0.000 description 2
- 206010000830 Acute leukaemia Diseases 0.000 description 2
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 2
- 241000143060 Americamysis bahia Species 0.000 description 2
- 108020004491 Antisense DNA Proteins 0.000 description 2
- 108020005544 Antisense RNA Proteins 0.000 description 2
- 241000701066 Bovine gammaherpesvirus 4 Species 0.000 description 2
- 208000003174 Brain Neoplasms Diseases 0.000 description 2
- 101100385576 Caenorhabditis elegans ctg-1 gene Proteins 0.000 description 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 2
- 108090000994 Catalytic RNA Proteins 0.000 description 2
- 102000053642 Catalytic RNA Human genes 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 241000186216 Corynebacterium Species 0.000 description 2
- 101710160937 DNA replication protein Proteins 0.000 description 2
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 description 2
- 241001115402 Ebolavirus Species 0.000 description 2
- 241001464851 Entamoeba invadens Species 0.000 description 2
- 241000282324 Felis Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 206010069767 H1N1 influenza Diseases 0.000 description 2
- 241000712431 Influenza A virus Species 0.000 description 2
- 241001500350 Influenzavirus B Species 0.000 description 2
- 241000879605 Isolepis prolifera Species 0.000 description 2
- 101100193693 Kirsten murine sarcoma virus K-RAS gene Proteins 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- 241000422392 Laurencia Species 0.000 description 2
- 241000713666 Lentivirus Species 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 206010064912 Malignant transformation Diseases 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 241000204031 Mycoplasma Species 0.000 description 2
- 206010029260 Neuroblastoma Diseases 0.000 description 2
- 108700020796 Oncogene Proteins 0.000 description 2
- 241000221871 Ophiostoma Species 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 241000235648 Pichia Species 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 108010021833 Proto-Oncogene Proteins c-yes Proteins 0.000 description 2
- 102000007696 Proto-Oncogene Proteins c-yes Human genes 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 101710088839 Replication initiation protein Proteins 0.000 description 2
- 101710203837 Replication-associated protein Proteins 0.000 description 2
- 101710090029 Replication-associated protein A Proteins 0.000 description 2
- 102000001332 SRC Human genes 0.000 description 2
- 108060006706 SRC Proteins 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- 241000187747 Streptomyces Species 0.000 description 2
- 101710172711 Structural protein Proteins 0.000 description 2
- 241000282898 Sus scrofa Species 0.000 description 2
- 229940100514 Syk tyrosine kinase inhibitor Drugs 0.000 description 2
- 102100021869 Tyrosine aminotransferase Human genes 0.000 description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
- 108700005077 Viral Genes Proteins 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 150000007513 acids Chemical group 0.000 description 2
- 239000003816 antisense DNA Substances 0.000 description 2
- 208000005266 avian sarcoma Diseases 0.000 description 2
- OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 125000000837 carbohydrate group Chemical group 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 239000003184 complementary RNA Substances 0.000 description 2
- 108700010904 coronavirus proteins Proteins 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 238000005034 decoration Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000010460 detection of virus Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000005059 dormancy Effects 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 230000002550 fecal effect Effects 0.000 description 2
- 238000007429 general method Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 229940124735 malaria vaccine Drugs 0.000 description 2
- 230000036212 malign transformation Effects 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000003936 merozoite Anatomy 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229960005030 other vaccine in atc Drugs 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- 238000013081 phylogenetic analysis Methods 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 235000013594 poultry meat Nutrition 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 108091092562 ribozyme Proteins 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- 230000000405 serological effect Effects 0.000 description 2
- 239000010865 sewage Substances 0.000 description 2
- 238000004904 shortening Methods 0.000 description 2
- 229940083538 smallpox vaccine Drugs 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 210000003934 vacuole Anatomy 0.000 description 2
- 239000004474 valine Substances 0.000 description 2
- 230000029812 viral genome replication Effects 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 description 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- 108091027075 5S-rRNA precursor Proteins 0.000 description 1
- 241000235389 Absidia Species 0.000 description 1
- 241000224422 Acanthamoeba Species 0.000 description 1
- 241000589220 Acetobacter Species 0.000 description 1
- 241000590020 Achromobacter Species 0.000 description 1
- 241000186046 Actinomyces Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 102100034540 Adenomatous polyposis coli protein Human genes 0.000 description 1
- 241001134800 Ahnfeltia Species 0.000 description 1
- 241000588986 Alcaligenes Species 0.000 description 1
- 241001492423 Amoebidae Species 0.000 description 1
- 241000219194 Arabidopsis Species 0.000 description 1
- 229930091051 Arenine Natural products 0.000 description 1
- 241000186063 Arthrobacter Species 0.000 description 1
- 241000512260 Ascophyllum Species 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- 241000589151 Azotobacter Species 0.000 description 1
- 102000051618 BRCA1-associated protein Human genes 0.000 description 1
- 108700039023 BRCA1-associated protein Proteins 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000186146 Brevibacterium Species 0.000 description 1
- 208000011691 Burkitt lymphomas Diseases 0.000 description 1
- 101100190466 Caenorhabditis elegans pid-3 gene Proteins 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 241001290342 Caulerpa Species 0.000 description 1
- 241001290348 Caulerpa mexicana Species 0.000 description 1
- 241000766401 Caulerpa verticillata Species 0.000 description 1
- 241001619326 Cephalosporium Species 0.000 description 1
- 241000206576 Chondrus Species 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 108010061994 Coronavirus Spike Glycoprotein Proteins 0.000 description 1
- 241001337994 Cryptococcus <scale insect> Species 0.000 description 1
- 241000252233 Cyprinus carpio Species 0.000 description 1
- GSNRZJNHMVMOFV-ACZMJKKPSA-N Cys-Asp-Glu Chemical compound C(CC(=O)O)[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)N GSNRZJNHMVMOFV-ACZMJKKPSA-N 0.000 description 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 1
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
- 102000052510 DNA-Binding Proteins Human genes 0.000 description 1
- 101710096438 DNA-binding protein Proteins 0.000 description 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 description 1
- 244000002639 Delonix regia Species 0.000 description 1
- 208000002699 Digestive System Neoplasms Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000224431 Entamoeba Species 0.000 description 1
- 241000588698 Erwinia Species 0.000 description 1
- 241000221787 Erysiphe Species 0.000 description 1
- 241001428166 Eucheuma Species 0.000 description 1
- 208000002476 Falciparum Malaria Diseases 0.000 description 1
- 241000713800 Feline immunodeficiency virus Species 0.000 description 1
- 102000003969 Fibroblast growth factor 4 Human genes 0.000 description 1
- 108090000381 Fibroblast growth factor 4 Proteins 0.000 description 1
- 241000589565 Flavobacterium Species 0.000 description 1
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 1
- 241000195480 Fucus Species 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 241000206672 Gelidium Species 0.000 description 1
- JESJDAAGXULQOP-CIUDSAMLSA-N Gln-Arg-Ser Chemical compound C(C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCC(=O)N)N)CN=C(N)N JESJDAAGXULQOP-CIUDSAMLSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 241000206581 Gracilaria Species 0.000 description 1
- 229940033330 HIV vaccine Drugs 0.000 description 1
- 241000606790 Haemophilus Species 0.000 description 1
- 241000248841 Halimeda Species 0.000 description 1
- 241000680944 Halimeda tuna Species 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 241000893570 Hendra henipavirus Species 0.000 description 1
- 208000037319 Hepatitis infectious Diseases 0.000 description 1
- 101710121996 Hexon protein p72 Proteins 0.000 description 1
- 101710103773 Histone H2B Proteins 0.000 description 1
- 102100021639 Histone H2B type 1-K Human genes 0.000 description 1
- 101000924577 Homo sapiens Adenomatous polyposis coli protein Proteins 0.000 description 1
- 101000739160 Homo sapiens Secretoglobin family 3A member 1 Proteins 0.000 description 1
- 101000823955 Homo sapiens Serine palmitoyltransferase 1 Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 241000598436 Human T-cell lymphotropic virus Species 0.000 description 1
- 241000701806 Human papillomavirus Species 0.000 description 1
- YSGBJIQXTIVBHZ-AJNGGQMLSA-N Ile-Lys-Leu Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O YSGBJIQXTIVBHZ-AJNGGQMLSA-N 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 206010061217 Infestation Diseases 0.000 description 1
- 241001500351 Influenzavirus A Species 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108020003285 Isocitrate lyase Proteins 0.000 description 1
- 208000007766 Kaposi sarcoma Diseases 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 241001466453 Laminaria Species 0.000 description 1
- 101710128836 Large T antigen Proteins 0.000 description 1
- 241000272168 Laridae Species 0.000 description 1
- 241000589248 Legionella Species 0.000 description 1
- 208000007764 Legionnaires' Disease Diseases 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 241001491708 Macrocystis Species 0.000 description 1
- 108010058398 Macrophage Colony-Stimulating Factor Receptor Proteins 0.000 description 1
- 101710155214 Macrophage infectivity potentiator Proteins 0.000 description 1
- 101710125418 Major capsid protein Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001502481 Meleagrid alphaherpesvirus 1 Species 0.000 description 1
- IHITVQKJXQQGLJ-LPEHRKFASA-N Met-Asn-Pro Chemical compound CSCC[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@@H]1C(=O)O)N IHITVQKJXQQGLJ-LPEHRKFASA-N 0.000 description 1
- 241000589344 Methylomonas Species 0.000 description 1
- 241000192041 Micrococcus Species 0.000 description 1
- 101710202709 Middle T antigen Proteins 0.000 description 1
- 241000235395 Mucor Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 108700026495 N-Myc Proto-Oncogene Proteins 0.000 description 1
- 102000055056 N-Myc Proto-Oncogene Human genes 0.000 description 1
- XMBSYZWANAQXEV-UHFFFAOYSA-N N-alpha-L-glutamyl-L-phenylalanine Natural products OC(=O)CCC(N)C(=O)NC(C(O)=O)CC1=CC=CC=C1 XMBSYZWANAQXEV-UHFFFAOYSA-N 0.000 description 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 description 1
- 108010057466 NF-kappa B Proteins 0.000 description 1
- 102000003945 NF-kappa B Human genes 0.000 description 1
- 241000224436 Naegleria Species 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 108090000189 Neuropeptides Proteins 0.000 description 1
- 241000526636 Nipah henipavirus Species 0.000 description 1
- 241000187654 Nocardia Species 0.000 description 1
- 108010020361 Oncogene Protein gp140(v-fms) Proteins 0.000 description 1
- 241000144580 Ophiostoma novo-ulmi Species 0.000 description 1
- 208000009620 Orthomyxoviridae Infections Diseases 0.000 description 1
- 241000209094 Oryza Species 0.000 description 1
- 102000016979 Other receptors Human genes 0.000 description 1
- 101710114693 Outer membrane protein MIP Proteins 0.000 description 1
- 241001236817 Paecilomyces <Clavicipitaceae> Species 0.000 description 1
- 241001631646 Papillomaviridae Species 0.000 description 1
- 101500013104 Pelophylax ridibundus Secretoneurin Proteins 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- XEXSSIBQYNKFBX-KBPBESRZSA-N Phe-Gly-His Chemical compound C([C@H](N)C(=O)NCC(=O)N[C@@H](CC=1N=CNC=1)C(O)=O)C1=CC=CC=C1 XEXSSIBQYNKFBX-KBPBESRZSA-N 0.000 description 1
- 241000233622 Phytophthora infestans Species 0.000 description 1
- 241000224016 Plasmodium Species 0.000 description 1
- 201000011336 Plasmodium falciparum malaria Diseases 0.000 description 1
- 241000276498 Pollachius virens Species 0.000 description 1
- 241001135549 Porcine epidemic diarrhea virus Species 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 101710188053 Protein D Proteins 0.000 description 1
- 101710150114 Protein rep Proteins 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 108700020978 Proto-Oncogene Proteins 0.000 description 1
- 102000052575 Proto-Oncogene Human genes 0.000 description 1
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 description 1
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 102000044126 RNA-Binding Proteins Human genes 0.000 description 1
- 108700020471 RNA-Binding Proteins Proteins 0.000 description 1
- 101710118046 RNA-directed RNA polymerase Proteins 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108091081062 Repeated sequence (DNA) Proteins 0.000 description 1
- 101710152114 Replication protein Proteins 0.000 description 1
- 101710132893 Resolvase Proteins 0.000 description 1
- 241000589180 Rhizobium Species 0.000 description 1
- 241000235527 Rhizopus Species 0.000 description 1
- 241000206616 Rhodymenia Species 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 241000195474 Sargassum Species 0.000 description 1
- 241001282806 Sargassum natans Species 0.000 description 1
- 241000235346 Schizosaccharomyces Species 0.000 description 1
- 241000235347 Schizosaccharomyces pombe Species 0.000 description 1
- 102100037268 Secretoglobin family 3A member 1 Human genes 0.000 description 1
- 102100022068 Serine palmitoyltransferase 1 Human genes 0.000 description 1
- 241000607720 Serratia Species 0.000 description 1
- 241000710960 Sindbis virus Species 0.000 description 1
- 101710185500 Small t antigen Proteins 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 241000203590 Streptosporangium Species 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 241001523006 Talaromyces marneffei Species 0.000 description 1
- BTAJAOWZCWOHBU-HSHDSVGOSA-N Thr-Val-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)O)C(C)C)C(O)=O)=CNC2=C1 BTAJAOWZCWOHBU-HSHDSVGOSA-N 0.000 description 1
- 102000006601 Thymidine Kinase Human genes 0.000 description 1
- 108020004440 Thymidine kinase Proteins 0.000 description 1
- 102100037357 Thymidylate kinase Human genes 0.000 description 1
- 102000002689 Toll-like receptor Human genes 0.000 description 1
- 108020000411 Toll-like receptor Proteins 0.000 description 1
- 101710100570 Transforming protein Myb Proteins 0.000 description 1
- 241000223259 Trichoderma Species 0.000 description 1
- 229910052770 Uranium Inorganic materials 0.000 description 1
- VBTFUDNTMCHPII-UHFFFAOYSA-N Val-Trp-Tyr Natural products C=1NC2=CC=CC=C2C=1CC(NC(=O)C(N)C(C)C)C(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 VBTFUDNTMCHPII-UHFFFAOYSA-N 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 206010048215 Xanthomatosis Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 201000009840 acute diarrhea Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
- 229960003805 amantadine Drugs 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000004099 anaerobic respiration Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000000078 anti-malarial effect Effects 0.000 description 1
- 230000002223 anti-pathogen Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 238000009175 antibody therapy Methods 0.000 description 1
- 239000003430 antimalarial agent Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 108010090946 astrocytin Proteins 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 208000024055 brain glioblastoma Diseases 0.000 description 1
- 201000011609 brain glioblastoma multiforme Diseases 0.000 description 1
- 201000007983 brain glioma Diseases 0.000 description 1
- 201000008275 breast carcinoma Diseases 0.000 description 1
- 208000030270 breast disease Diseases 0.000 description 1
- 208000003362 bronchogenic carcinoma Diseases 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 238000009566 cancer vaccine Methods 0.000 description 1
- 229940022399 cancer vaccine Drugs 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000010307 cell transformation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 239000012707 chemical precursor Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 108010000742 dTMP kinase Proteins 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 229940042406 direct acting antivirals neuraminidase inhibitors Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 235000019688 fish Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 108010074605 gamma-Globulins Proteins 0.000 description 1
- 229960002963 ganciclovir Drugs 0.000 description 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 201000010231 gastrointestinal system cancer Diseases 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 108091006104 gene-regulatory proteins Proteins 0.000 description 1
- 102000034356 gene-regulatory proteins Human genes 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 208000031169 hemorrhagic disease Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000006054 immunological memory Effects 0.000 description 1
- 238000012296 in situ hybridization assay Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 108700010900 influenza virus proteins Proteins 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 230000017066 negative regulation of growth Effects 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 229960003752 oseltamivir Drugs 0.000 description 1
- VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 230000008635 plant growth Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 238000000575 proteomic method Methods 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 108010068258 recognins Proteins 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229960000888 rimantadine Drugs 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 210000001563 schizont Anatomy 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002911 sialidase inhibitor Substances 0.000 description 1
- 102000030938 small GTPase Human genes 0.000 description 1
- 108060007624 small GTPase Proteins 0.000 description 1
- MSXHSNHNTORCAW-MPGIDXPLSA-M sodium;(3s,4s,5s,6r)-3,4,5,6-tetrahydroxyoxane-2-carboxylate Chemical compound [Na+].O[C@@H]1OC(C([O-])=O)[C@@H](O)[C@H](O)[C@@H]1O MSXHSNHNTORCAW-MPGIDXPLSA-M 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 208000001608 teratocarcinoma Diseases 0.000 description 1
- 229940021747 therapeutic vaccine Drugs 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000005029 transcription elongation Effects 0.000 description 1
- 230000005026 transcription initiation Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 210000003812 trophozoite Anatomy 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 229940125575 vaccine candidate Drugs 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 230000009447 viral pathogenesis Effects 0.000 description 1
- 229960004854 viral vaccine Drugs 0.000 description 1
- 238000004018 waxing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 229960001028 zanamivir Drugs 0.000 description 1
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Evolutionary Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65308305P | 2005-02-16 | 2005-02-16 | |
| US60/653,083 | 2005-02-16 | ||
| USPCT/US2005/014443 | 2005-04-28 | ||
| PCT/US2005/014443 WO2005104754A2 (en) | 2004-04-28 | 2005-04-28 | System and method for identifying complex patterns of amino acids |
| PCT/US2006/005343 WO2006088962A2 (en) | 2005-02-16 | 2006-02-16 | Replikin peptides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2598381A1 true CA2598381A1 (en) | 2006-08-24 |
Family
ID=36917023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002598381A Abandoned CA2598381A1 (en) | 2005-02-16 | 2006-02-16 | Replikin peptides and uses thereof |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1859063A4 (OSRAM) |
| JP (1) | JP2008539164A (OSRAM) |
| AU (1) | AU2006214332B2 (OSRAM) |
| CA (1) | CA2598381A1 (OSRAM) |
| IL (1) | IL185308A0 (OSRAM) |
| NZ (1) | NZ560415A (OSRAM) |
| SG (1) | SG160327A1 (OSRAM) |
| WO (1) | WO2006088962A2 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7420028B2 (en) | 2001-03-27 | 2008-09-02 | Samuel Bogoch | Replikins and methods of identifying replikin-containing sequences |
| US7682619B2 (en) | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
| JP5174014B2 (ja) * | 2006-05-30 | 2013-04-03 | ボゴーク，サミュエル | レプリキンペプチドおよびその使用 |
| EP2092059A4 (en) | 2006-10-24 | 2012-03-28 | Bogoch Samuel | METHOD FOR FORECASTING INFLUENZA EXCESSIONS BY CORRELATION OF AN INCREASED REPLICINE MIRROR IN WHITE SPOT AND / OR TAURA VIRUSES IN CRABES |
| EP2126140A4 (en) * | 2007-01-18 | 2012-03-28 | Samuel Bogoch | METHOD FOR DETERMINING THE MORTALITY OF PATHOGENS AND MALIGNOMAS WITH REPLICINE TIPS |
| JP5675348B2 (ja) * | 2007-05-30 | 2015-02-25 | ボゴーク，サミュエル | 水産養殖における無脊椎動物の病原性感染に対する合成レプリキンペプチド |
| EP2300493A2 (en) * | 2008-04-23 | 2011-03-30 | Samuel Bogoch | Methods and compounds for mitigating pathogenic outbreaks using replikin count cycles |
| CA2733461A1 (en) * | 2008-08-08 | 2010-02-11 | Samuel Bogoch | Methods of predicting cancer lethality using replikin counts |
| US9233148B2 (en) * | 2009-01-09 | 2016-01-12 | Samuel Bogoch | Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza |
| CA2759325A1 (en) * | 2009-04-23 | 2010-10-28 | Samuel Bogoch | Replikin-sequences for preventing/treating influenza and determining infectivity/lethality |
| WO2013013075A2 (en) | 2011-07-20 | 2013-01-24 | Samuel Bogoch | Peptides shared among lethal cancers and therapeutic compositions comprising said peptides |
| US20130243803A1 (en) | 2012-03-09 | 2013-09-19 | Samuel Bogoch | Therapies, vaccines, and predictive methods for infectious salmon anemia virus |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0221748A3 (en) | 1985-11-01 | 1988-10-12 | Samuel Dr. Bogoch | A process for the production of human antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US6242578B1 (en) | 1994-02-17 | 2001-06-05 | Samuel Bogoch | Aglyco products and methods of use |
| US7442761B2 (en) * | 2003-06-06 | 2008-10-28 | Samuel Bogoch | Replikin peptides and uses thereof |
| US7420028B2 (en) * | 2001-03-27 | 2008-09-02 | Samuel Bogoch | Replikins and methods of identifying replikin-containing sequences |
| US11620305B2 (en) | 2021-03-25 | 2023-04-04 | Salesforce.Com, Inc | Ruleset engine for generating homogeneous data sets |
-
2006
- 2006-02-16 EP EP06735145A patent/EP1859063A4/en not_active Withdrawn
- 2006-02-16 WO PCT/US2006/005343 patent/WO2006088962A2/en not_active Ceased
- 2006-02-16 CA CA002598381A patent/CA2598381A1/en not_active Abandoned
- 2006-02-16 SG SG201001000-7A patent/SG160327A1/en unknown
- 2006-02-16 AU AU2006214332A patent/AU2006214332B2/en not_active Ceased
- 2006-02-16 JP JP2007555371A patent/JP2008539164A/ja active Pending
- 2006-02-16 NZ NZ560415A patent/NZ560415A/en not_active IP Right Cessation
-
2007
- 2007-08-16 IL IL185308A patent/IL185308A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006088962A2 (en) | 2006-08-24 |
| AU2006214332A1 (en) | 2006-08-24 |
| EP1859063A4 (en) | 2012-02-01 |
| SG160327A1 (en) | 2010-04-29 |
| JP2008539164A (ja) | 2008-11-13 |
| WO2006088962A9 (en) | 2006-11-16 |
| WO2006088962A3 (en) | 2008-01-24 |
| NZ560415A (en) | 2010-05-28 |
| EP1859063A2 (en) | 2007-11-28 |
| IL185308A0 (en) | 2008-02-09 |
| AU2006214332B2 (en) | 2012-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7894999B2 (en) | Systems and methods for identifying Replikin Scaffolds and uses of said Replikin Scaffolds | |
| AU2010241262B2 (en) | Replikin peptides and uses thereof | |
| US9133247B2 (en) | Replikin peptides in rapid replication of glioma cells and in influenza epidemics | |
| AU2010200602B2 (en) | Replikin peptides and uses thereof | |
| US9388234B2 (en) | Systems and methods for identifying Replikin Scaffolds and uses of said Replikin Scaffolds | |
| Luczo et al. | Epitopes in the HA and NA of H5 and H7 avian influenza viruses that are important for antigenic drift | |
| AU2006214332B2 (en) | Replikin peptides and uses thereof | |
| EP2027146A2 (en) | Replikin peptides and uses thereof | |
| US9254315B2 (en) | Systems and methods for identifying replikin scaffolds and uses of said replikin scaffolds | |
| NZ584367A (en) | Systems and methods for indentifying Replikin scaffolds and uses of said Replikin scaffolds | |
| AU2013201657A1 (en) | Replikin peptides and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20150710 |
|
| FZDE | Discontinued |
Effective date: 20150710 |