CA2591516A1 - An autonomous method for oral delivery of a healing substance to a target place in gastrointestinal tract of humans or animals - Google Patents
An autonomous method for oral delivery of a healing substance to a target place in gastrointestinal tract of humans or animals Download PDFInfo
- Publication number
- CA2591516A1 CA2591516A1 CA002591516A CA2591516A CA2591516A1 CA 2591516 A1 CA2591516 A1 CA 2591516A1 CA 002591516 A CA002591516 A CA 002591516A CA 2591516 A CA2591516 A CA 2591516A CA 2591516 A1 CA2591516 A1 CA 2591516A1
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- Canada
- Prior art keywords
- healing substance
- capsule
- healing
- targeted
- place
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000126 substance Substances 0.000 title claims abstract description 36
- 230000035876 healing Effects 0.000 title claims abstract description 35
- 238000000034 method Methods 0.000 title claims abstract description 16
- 210000001035 gastrointestinal tract Anatomy 0.000 title claims abstract description 15
- 241001465754 Metazoa Species 0.000 title description 3
- 239000002775 capsule Substances 0.000 claims abstract description 27
- 210000004369 blood Anatomy 0.000 claims description 5
- 239000008280 blood Substances 0.000 claims description 5
- 238000002604 ultrasonography Methods 0.000 claims description 2
- 229910052729 chemical element Inorganic materials 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000007789 gas Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 abstract description 13
- 108090000623 proteins and genes Proteins 0.000 abstract description 13
- 239000002547 new drug Substances 0.000 abstract description 4
- 238000003384 imaging method Methods 0.000 description 9
- 102000004196 processed proteins & peptides Human genes 0.000 description 9
- 108090000765 processed proteins & peptides Proteins 0.000 description 9
- 230000008685 targeting Effects 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 241000167880 Hirundinidae Species 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000012382 advanced drug delivery Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
A method for oral delivery of new drugs, big molecules, proteins, and healing substances to a target place in the body, via digestive tract, using autonomous mobile self-controlled capsules with sensors.
Description
TI.TLE OF INVENTION
An autonomous method for oral delivery of a healing substance to a target place in gastrointestinal tract of humans or animals.
BACKGROUND OF THE INVENTION
1. Field of the Invention The current invention relates to oral autonomous high precision drug and healing substances/agents delivery methods in humans and animals.
An autonomous method for oral delivery of a healing substance to a target place in gastrointestinal tract of humans or animals.
BACKGROUND OF THE INVENTION
1. Field of the Invention The current invention relates to oral autonomous high precision drug and healing substances/agents delivery methods in humans and animals.
2. Background Information The field of advanced drug delivery is more than thirty years old. There are two main problems with oral delivering of healing substances such as proteins and biotech bio-molecules. The first problem is in the destruction of big healing substances such as proteins, peptides or big molecules by the agents in the digestive systems if these healing substances were taken orally. The second problem is in inaccuracy of targeting damaged regions. For example, chemotherapy may damage non-cancerous cells, because there is no way to detect with high precision cancerous cells inside the gastrointestinal tract by current chemical therapy and radiological therapy methods.
More than thousands of methods were proposed for solutions of these problems, which include the usage of electric field, and/or magnetic field, and/or ultrasound, and/or light, and/or enzymes, and/or viruses, and/or temperature, and/or pH, and/or mico-sized valves/chambers/pumps, and/or smart-microchips, and/or biopolymers, and/or nanoparticles, etc. Although some of these delivery technologies may be effective they are not cost efficient today and usually are restricted to the specific drugs, which can be delivered by these methods.
In the previous patent applications 2,579,611 filed on 2007/02/21, the inventor suggests a reliable, low-cost, non-restricted to particular drugs, and convenient method for oral delivery of new drugs, big molecules, proteins, and other healing substances to the targeted place in the body via digestive tract, using currently available technologies of mobile wireless controlled capsules with sensors. The main disadvantage of the invention is non-autonomous control system, which rely on external expert/operator.
The current patent application describes a method for oral delivery of new drugs, molecules, proteins, and other healing substances to the targeted place in the body via digestive tract, using the autonomous mobile self-controlled capsules directed by control systems on the internal chip inside the capsule.
BRIEF SUMMARY OF THE INVENTION
The current invention consists in using autonomous self-controlled capsules with imaging sensors to deliver healing substances to the target place in the gastro-digestive tract.
Autonomous self-controlled capsules with imaging sensors and control system on the internal chip allow delivering of healing substances to a targeted region with very high precision, which allow to solve the problem of high precision targeting of damaged regions and to avoid exposure of non-damaged regions to healing substances.
The second advantage of the current invention consist in delivery of peptides, proteins, and other big molecular structures, which are normally decomposed in the digestive tract if taken orally, into blood stream without their exposure to digestive machinery and without modifications in their structure and function. The third advantage of the current invention is autonomous self-control system on the internal chip, which allow using such pills in home environment without a need for specialized equipment and expert.
DETAILED DESCRIl'TION OF THE INVENTION
The present invention is directed to a method for oral delivery of new drugs, big molecules, proteins, healing substances to a target place in the body, via digestive tract, using autonomous self-controlled mobile capsules with sensors.
More than thousands of methods were proposed for solutions of these problems, which include the usage of electric field, and/or magnetic field, and/or ultrasound, and/or light, and/or enzymes, and/or viruses, and/or temperature, and/or pH, and/or mico-sized valves/chambers/pumps, and/or smart-microchips, and/or biopolymers, and/or nanoparticles, etc. Although some of these delivery technologies may be effective they are not cost efficient today and usually are restricted to the specific drugs, which can be delivered by these methods.
In the previous patent applications 2,579,611 filed on 2007/02/21, the inventor suggests a reliable, low-cost, non-restricted to particular drugs, and convenient method for oral delivery of new drugs, big molecules, proteins, and other healing substances to the targeted place in the body via digestive tract, using currently available technologies of mobile wireless controlled capsules with sensors. The main disadvantage of the invention is non-autonomous control system, which rely on external expert/operator.
The current patent application describes a method for oral delivery of new drugs, molecules, proteins, and other healing substances to the targeted place in the body via digestive tract, using the autonomous mobile self-controlled capsules directed by control systems on the internal chip inside the capsule.
BRIEF SUMMARY OF THE INVENTION
The current invention consists in using autonomous self-controlled capsules with imaging sensors to deliver healing substances to the target place in the gastro-digestive tract.
Autonomous self-controlled capsules with imaging sensors and control system on the internal chip allow delivering of healing substances to a targeted region with very high precision, which allow to solve the problem of high precision targeting of damaged regions and to avoid exposure of non-damaged regions to healing substances.
The second advantage of the current invention consist in delivery of peptides, proteins, and other big molecular structures, which are normally decomposed in the digestive tract if taken orally, into blood stream without their exposure to digestive machinery and without modifications in their structure and function. The third advantage of the current invention is autonomous self-control system on the internal chip, which allow using such pills in home environment without a need for specialized equipment and expert.
DETAILED DESCRIl'TION OF THE INVENTION
The present invention is directed to a method for oral delivery of new drugs, big molecules, proteins, healing substances to a target place in the body, via digestive tract, using autonomous self-controlled mobile capsules with sensors.
The mobile capsules, for example modifications of PillCam manufactured by Given Imaging, Inc. or SmartPills manufactured by SmartPill Corporation have imaging sensors, chip on which targeted region image and control system are stored and healing substance delivery mechanism for delivery of healing substances with high precision, convenience for patients, and with low costs.
The internal control system on the chip compare images receiving from imaging sensors with the image of a target region, which is stored on the current or a separate chip. If the current image is similar to the pre-stored on the chip image of the target region then the control system activates the healing substance delivery mechanism for delivery of healing substance. This mechanism directs the healing substance to the targeted place.
Autonomous self-controlled mobile capsules with imaging sensors allow delivering healing substances to a targeted region with very high precision, which allow solving the problem of high precision targeting of damaged regions and avoiding exposure of non-damaged regions to healing substances.
The invention is described below on several examples.
Example 1. Cancer in gastrointestinal tract The delivery part of autonomous mobile self-controlled capsule is loaded with a healing :u bstance, for example, molecules with special receptors with attached chemical or radioactive agent to treat cancerous cells. On the chip of the capsule an image of a targeted region of a cancer place is loaded. A patient swallows the capsule, which sends images of gastrointestinal tract to the control system as it travels in the tract. The control sustem analyzes the images captured by the imaging sensors of the capsule.
When the control system detects that the capsule is close enough to the target region, the control system direct the healing substance to the target. This command is executed by capsule healing substance delivery mechanism, which may be any standard mechanism used today, for example, injectors, micro guns, pushers, pumps, etc. The healing substance moves to the target region, sticks to the target, and treats the cancer.
Example 2. Delivering proteins or peptides into the blood system.
The delivery part of mobile autonomous self-controlled capsule is loaded with proteins or peptides. On the chip of the capsule an image of a targeted region is loaded.
A patient swallows the capsule, which sends images, captured by the imaging sensors, of gastrointestinal tract to the control system as it travels in the tract. The control system analyzes the images captured by the imaging sensors of the capsule. When the control system detects that the capsule passed the region where the proteins or peptides are destroved by digestive enzymes in the gastrointestinal tract, the signal is sent to the healing substance delivery mechanism to release the proteins or peptides. This commant.
is executed by capsule healing substance delivery mechanism, which release the proteiils or peptides. These proteins or peptides then flow undamaged into the blood system.
The advantage of the current invention consist in delivery of peptides, proteins, and other big molecular structures, which are normally decomposed in digestive tract if taken orally, into blood stream without their exposure to digestive machinery and without modifications in their structure and function.
The next advantage of the current invention is the high accuracy of targeting the damaged regions.
The next advantage of the current invention is high degree of safety for using this method.
The next advantage of the current invention is possibility to use it without a need for specialized equipment and expert in home environment.
The internal control system on the chip compare images receiving from imaging sensors with the image of a target region, which is stored on the current or a separate chip. If the current image is similar to the pre-stored on the chip image of the target region then the control system activates the healing substance delivery mechanism for delivery of healing substance. This mechanism directs the healing substance to the targeted place.
Autonomous self-controlled mobile capsules with imaging sensors allow delivering healing substances to a targeted region with very high precision, which allow solving the problem of high precision targeting of damaged regions and avoiding exposure of non-damaged regions to healing substances.
The invention is described below on several examples.
Example 1. Cancer in gastrointestinal tract The delivery part of autonomous mobile self-controlled capsule is loaded with a healing :u bstance, for example, molecules with special receptors with attached chemical or radioactive agent to treat cancerous cells. On the chip of the capsule an image of a targeted region of a cancer place is loaded. A patient swallows the capsule, which sends images of gastrointestinal tract to the control system as it travels in the tract. The control sustem analyzes the images captured by the imaging sensors of the capsule.
When the control system detects that the capsule is close enough to the target region, the control system direct the healing substance to the target. This command is executed by capsule healing substance delivery mechanism, which may be any standard mechanism used today, for example, injectors, micro guns, pushers, pumps, etc. The healing substance moves to the target region, sticks to the target, and treats the cancer.
Example 2. Delivering proteins or peptides into the blood system.
The delivery part of mobile autonomous self-controlled capsule is loaded with proteins or peptides. On the chip of the capsule an image of a targeted region is loaded.
A patient swallows the capsule, which sends images, captured by the imaging sensors, of gastrointestinal tract to the control system as it travels in the tract. The control system analyzes the images captured by the imaging sensors of the capsule. When the control system detects that the capsule passed the region where the proteins or peptides are destroved by digestive enzymes in the gastrointestinal tract, the signal is sent to the healing substance delivery mechanism to release the proteins or peptides. This commant.
is executed by capsule healing substance delivery mechanism, which release the proteiils or peptides. These proteins or peptides then flow undamaged into the blood system.
The advantage of the current invention consist in delivery of peptides, proteins, and other big molecular structures, which are normally decomposed in digestive tract if taken orally, into blood stream without their exposure to digestive machinery and without modifications in their structure and function.
The next advantage of the current invention is the high accuracy of targeting the damaged regions.
The next advantage of the current invention is high degree of safety for using this method.
The next advantage of the current invention is possibility to use it without a need for specialized equipment and expert in home environment.
Claims (6)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A method for delivery of a healing substance to a target place in gastrointestinal tract or blood system, comprising the following steps:
a). A healing substance is placed into a mobile self-controlled capsule with sensors and internal chip (or chips).
b). An image of a targeted region is loaded into memory of the chip c). The capsule enters into the gastrointestinal tract via mouth of a patient with food or water and moves toward the targeted place, d). The capsule is directed to the targeted place via control signals sent from a control unit in the internal chip. The signals from the sensors are sent to the control system on the internal chip inside the capsule.
e). The control system compares images received from the sensors with the image of the targeted place stored on the chip.
g). When the capsule reach the targeted place the control unit send signal to release the healing substance and this healing substance is released from the capsule and directed to the targeted place.
a). A healing substance is placed into a mobile self-controlled capsule with sensors and internal chip (or chips).
b). An image of a targeted region is loaded into memory of the chip c). The capsule enters into the gastrointestinal tract via mouth of a patient with food or water and moves toward the targeted place, d). The capsule is directed to the targeted place via control signals sent from a control unit in the internal chip. The signals from the sensors are sent to the control system on the internal chip inside the capsule.
e). The control system compares images received from the sensors with the image of the targeted place stored on the chip.
g). When the capsule reach the targeted place the control unit send signal to release the healing substance and this healing substance is released from the capsule and directed to the targeted place.
2. The method as in claim 1, where the healing substance is a composition of chemical elements in solid or fluid or gases form.
3. The method as in claim 1, where the healing substance is a set of electromagnetic waves.
4. The method as in claim 1, where the healing substance is a set of mechanical waves.
5. The method as in claim 1, where the healing substance is a set of sound or ultrasound waves.
6. The method as in claim 1, where the healing substance is a flow of physical particles.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002591516A CA2591516A1 (en) | 2007-05-02 | 2007-05-02 | An autonomous method for oral delivery of a healing substance to a target place in gastrointestinal tract of humans or animals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002591516A CA2591516A1 (en) | 2007-05-02 | 2007-05-02 | An autonomous method for oral delivery of a healing substance to a target place in gastrointestinal tract of humans or animals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2591516A1 true CA2591516A1 (en) | 2008-11-02 |
Family
ID=39941648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002591516A Abandoned CA2591516A1 (en) | 2007-05-02 | 2007-05-02 | An autonomous method for oral delivery of a healing substance to a target place in gastrointestinal tract of humans or animals |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2591516A1 (en) |
-
2007
- 2007-05-02 CA CA002591516A patent/CA2591516A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| EEER | Examination request |
Effective date: 20111102 |
|
| EEER | Examination request |
Effective date: 20111102 |
|
| EEER | Examination request |
Effective date: 20111102 |
|
| FZDE | Discontinued |
Effective date: 20231102 |