CA2589421A1 - Erbb3 antibodies - Google Patents
Erbb3 antibodies Download PDFInfo
- Publication number
- CA2589421A1 CA2589421A1 CA002589421A CA2589421A CA2589421A1 CA 2589421 A1 CA2589421 A1 CA 2589421A1 CA 002589421 A CA002589421 A CA 002589421A CA 2589421 A CA2589421 A CA 2589421A CA 2589421 A1 CA2589421 A1 CA 2589421A1
- Authority
- CA
- Canada
- Prior art keywords
- erbb3
- erbb2
- heregulin
- cell
- ability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101150082819 ERBB3 gene Proteins 0.000 title 1
- 102000048238 Neuregulin-1 Human genes 0.000 claims abstract 5
- 108090000556 Neuregulin-1 Proteins 0.000 claims abstract 5
- 102000056372 ErbB-3 Receptor Human genes 0.000 claims abstract 3
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims abstract 3
- 230000004913 activation Effects 0.000 claims abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Antibodies are disclosed which bind to ErbB3 protein and further possess any one or more of the following properties: an ability to reduce heregulin-induced formation of an ErbB2-ErbB3 protein complex in a cell which expresses ErbB2 and ErbB3; the ability to increase the binding affinity of heregulin for ErbB3 protein; and the characteristic of reducing heregulin-induced ErbB2 activation in a cell which expresses ErbB2 and ErbB3.
Claims
1. An antibody which binds to ErbB3 protein, reduces heregulin binding thereto, and reduces heregulin-induced ErbB2 activation in a cell which expresses ErbB2 and ErbB3.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62403696A | 1996-03-27 | 1996-03-27 | |
US08/624,036 | 1996-03-27 | ||
CA002246429A CA2246429C (en) | 1996-03-27 | 1997-03-07 | Erbb3 antibodies |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002246429A Division CA2246429C (en) | 1996-03-27 | 1997-03-07 | Erbb3 antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2589421A1 true CA2589421A1 (en) | 1997-10-02 |
CA2589421C CA2589421C (en) | 2012-12-18 |
Family
ID=38326392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2589421A Expired - Lifetime CA2589421C (en) | 1996-03-27 | 1997-03-07 | Erbb3 antibodies |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2589421C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9085622B2 (en) | 2010-09-03 | 2015-07-21 | Glaxosmithkline Intellectual Property Development Limited | Antigen binding proteins |
-
1997
- 1997-03-07 CA CA2589421A patent/CA2589421C/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9085622B2 (en) | 2010-09-03 | 2015-07-21 | Glaxosmithkline Intellectual Property Development Limited | Antigen binding proteins |
Also Published As
Publication number | Publication date |
---|---|
CA2589421C (en) | 2012-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20170307 |