CA2588063C - 2-methylene-19,21-dinor-1.alpha.-hydroxy-bishomopregnacalciferol - Google Patents
2-methylene-19,21-dinor-1.alpha.-hydroxy-bishomopregnacalciferol Download PDFInfo
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- CA2588063C CA2588063C CA2588063A CA2588063A CA2588063C CA 2588063 C CA2588063 C CA 2588063C CA 2588063 A CA2588063 A CA 2588063A CA 2588063 A CA2588063 A CA 2588063A CA 2588063 C CA2588063 C CA 2588063C
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Classifications
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- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
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- Neurosurgery (AREA)
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- Biomedical Technology (AREA)
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- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62995804P | 2004-11-22 | 2004-11-22 | |
| US60/629,958 | 2004-11-22 | ||
| PCT/US2005/041888 WO2006057915A2 (en) | 2004-11-22 | 2005-11-18 | 2-methylene-19,21-dinor-1alpha-hydroxy-bishomopregnacalciferol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2588063A1 CA2588063A1 (en) | 2006-06-01 |
| CA2588063C true CA2588063C (en) | 2012-10-16 |
Family
ID=36498437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2588063A Expired - Fee Related CA2588063C (en) | 2004-11-22 | 2005-11-18 | 2-methylene-19,21-dinor-1.alpha.-hydroxy-bishomopregnacalciferol |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8604008B2 (enExample) |
| EP (1) | EP1827452B1 (enExample) |
| JP (1) | JP5036548B2 (enExample) |
| AT (1) | ATE499942T1 (enExample) |
| AU (1) | AU2005309820B2 (enExample) |
| CA (1) | CA2588063C (enExample) |
| DE (1) | DE602005026694D1 (enExample) |
| ES (1) | ES2358914T3 (enExample) |
| MX (1) | MX2007006094A (enExample) |
| NZ (1) | NZ555561A (enExample) |
| WO (1) | WO2006057915A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE499942T1 (de) | 2004-11-22 | 2011-03-15 | Wisconsin Alumni Res Found | 2-methylen-19,21-dinor-1alpha-hydroxy- bishomopregnacalciferol |
| AU2005309818A1 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20R)-1-alpha-hydroxy-bishomopregnacalciferol |
| US8993547B2 (en) * | 2011-06-14 | 2015-03-31 | Wisconsin Alumni Research Foundation | 3-desoxy-2-methylene-19-nor-vitamin D analogs and their uses |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| CA2062520C (en) | 1991-03-11 | 1998-08-11 | Hector F. Deluca | Synthesis of 1-alpha-hydroxy-secosterol compounds |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| JP2898882B2 (ja) * | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物 |
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| US5891865A (en) * | 1996-10-04 | 1999-04-06 | Wisconsin Alumni Research Foundation | Treatment of arthritic disease induced by infectious agents |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5936105A (en) * | 1997-06-13 | 1999-08-10 | Tetrionics, Inc. | 14-EPI-19-nor-vitamin D compounds and methods |
| BR0113703A (pt) * | 2000-09-08 | 2003-07-22 | Wisconsin Alumni Researcg Foun | Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de pele |
| PT1453798E (pt) * | 2001-12-13 | 2009-01-23 | Wisconsin Alumni Res Found | (20s)-1alfa-hidroxi-2-metileno-19-nor-bishomopregnacalciferol e suas utilizações |
| US6835723B2 (en) * | 2001-12-13 | 2004-12-28 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-20(S)-1α-hydroxy-bis-homo-pregnacalciferol in crystalline form |
| US6627622B2 (en) | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| HK1079766B (zh) * | 2002-03-29 | 2007-05-25 | 威斯康星校友研究基金会 | 合成1α-羟基-2-亚甲基-19-去甲-高孕钙化醇的方法 |
| ATE537834T1 (de) * | 2003-08-20 | 2012-01-15 | Wisconsin Alumni Res Found | 2-methylen-19-nor-vitamin d2-verbindungen |
| CA2544502A1 (en) * | 2003-11-25 | 2005-06-09 | Wisconsin Alumni Research Foundation | Vitamin d analogs for obesity prevention and treatment |
| JP2008520709A (ja) * | 2004-11-22 | 2008-06-19 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１９−ノル−（２０Ｓ）−１α−ヒドロキシ−トリスホモプレグナカルシフェロール |
| AU2005309818A1 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20R)-1-alpha-hydroxy-bishomopregnacalciferol |
| NZ555283A (en) * | 2004-11-22 | 2010-12-24 | Wisconsin Alumni Res Found | 2alpha-methyl-19-nor-(20s)-1alpha-hydroxy-bishomopregnacalciferol and its uses |
| ATE499942T1 (de) | 2004-11-22 | 2011-03-15 | Wisconsin Alumni Res Found | 2-methylen-19,21-dinor-1alpha-hydroxy- bishomopregnacalciferol |
| AU2008345082B2 (en) * | 2007-12-28 | 2014-03-06 | Wisconsin Alumni Research Foundation | (20S)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs |
| JP2011508744A (ja) * | 2007-12-28 | 2011-03-17 | ウィスコンシン アラムナイ リサーチ ファンデーション | （２０ｒ）−２３，２３−ジフルオロ−２−メチレン−１９−ノル−ビスホモプレグナカルシフェロール−ビタミンｄ類縁体 |
-
2005
- 2005-11-18 AT AT05849207T patent/ATE499942T1/de not_active IP Right Cessation
- 2005-11-18 EP EP05849207A patent/EP1827452B1/en not_active Expired - Lifetime
- 2005-11-18 CA CA2588063A patent/CA2588063C/en not_active Expired - Fee Related
- 2005-11-18 ES ES05849207T patent/ES2358914T3/es not_active Expired - Lifetime
- 2005-11-18 NZ NZ555561A patent/NZ555561A/en not_active IP Right Cessation
- 2005-11-18 JP JP2007543291A patent/JP5036548B2/ja not_active Expired - Fee Related
- 2005-11-18 DE DE602005026694T patent/DE602005026694D1/de not_active Expired - Lifetime
- 2005-11-18 MX MX2007006094A patent/MX2007006094A/es active IP Right Grant
- 2005-11-18 WO PCT/US2005/041888 patent/WO2006057915A2/en not_active Ceased
- 2005-11-18 AU AU2005309820A patent/AU2005309820B2/en not_active Ceased
- 2005-11-18 US US11/283,541 patent/US8604008B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005309820B2 (en) | 2011-06-23 |
| EP1827452B1 (en) | 2011-03-02 |
| JP2008520710A (ja) | 2008-06-19 |
| AU2005309820A1 (en) | 2006-06-01 |
| US8604008B2 (en) | 2013-12-10 |
| DE602005026694D1 (de) | 2011-04-14 |
| US20060135800A1 (en) | 2006-06-22 |
| MX2007006094A (es) | 2007-07-11 |
| EP1827452A2 (en) | 2007-09-05 |
| JP5036548B2 (ja) | 2012-09-26 |
| CA2588063A1 (en) | 2006-06-01 |
| WO2006057915A2 (en) | 2006-06-01 |
| ATE499942T1 (de) | 2011-03-15 |
| EP1827452A4 (en) | 2009-10-21 |
| WO2006057915A3 (en) | 2006-07-13 |
| NZ555561A (en) | 2009-02-28 |
| ES2358914T3 (es) | 2011-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20210831 |
|
| MKLA | Lapsed |
Effective date: 20191118 |