CA2584873C - Antisense antiviral compounds and methods for treating a filovirus infection - Google Patents

Antisense antiviral compounds and methods for treating a filovirus infection Download PDF

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Publication number
CA2584873C
CA2584873C CA2584873A CA2584873A CA2584873C CA 2584873 C CA2584873 C CA 2584873C CA 2584873 A CA2584873 A CA 2584873A CA 2584873 A CA2584873 A CA 2584873A CA 2584873 C CA2584873 C CA 2584873C
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Canada
Prior art keywords
antiviral compound
seq
sequence
aug
base sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2584873A
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English (en)
French (fr)
Other versions
CA2584873A1 (en
Inventor
David A. Stein
Patrick L. Iversen
Sina Bavari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sarepta Therapeutics Inc
United States Department of the Army
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Sarepta Therapeutics Inc
United States Department of the Army
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Publication of CA2584873A1 publication Critical patent/CA2584873A1/en
Application granted granted Critical
Publication of CA2584873C publication Critical patent/CA2584873C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3513—Protein; Peptide

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2584873A 2004-11-01 2005-11-01 Antisense antiviral compounds and methods for treating a filovirus infection Expired - Fee Related CA2584873C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US62427704P 2004-11-01 2004-11-01
US60/624,277 2004-11-01
US67169405P 2005-04-14 2005-04-14
US60/671,694 2005-04-14
US11/264,444 US7524829B2 (en) 2004-11-01 2005-10-31 Antisense antiviral compounds and methods for treating a filovirus infection
US11/264,444 2005-10-31
PCT/US2005/039607 WO2006050414A2 (en) 2004-11-01 2005-11-01 Antisense antiviral compounds and methods for treating filovirus infection

Publications (2)

Publication Number Publication Date
CA2584873A1 CA2584873A1 (en) 2006-05-11
CA2584873C true CA2584873C (en) 2017-04-18

Family

ID=36319793

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2584873A Expired - Fee Related CA2584873C (en) 2004-11-01 2005-11-01 Antisense antiviral compounds and methods for treating a filovirus infection

Country Status (6)

Country Link
US (5) US7524829B2 (de)
EP (1) EP1814596B1 (de)
AT (1) ATE540116T1 (de)
AU (1) AU2005302155B2 (de)
CA (1) CA2584873C (de)
WO (1) WO2006050414A2 (de)

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US8785407B2 (en) * 2006-05-10 2014-07-22 Sarepta Therapeutics, Inc. Antisense antiviral agent and method for treating ssRNA viral infection
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KR101459530B1 (ko) * 2009-09-04 2014-11-07 유나이티드 세러퓨틱스 코오포레이션 폭스바이러스 감염의 치료 방법
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Also Published As

Publication number Publication date
WO2006050414A3 (en) 2007-11-01
US7524829B2 (en) 2009-04-28
EP1814596B1 (de) 2012-01-04
CA2584873A1 (en) 2006-05-11
ATE540116T1 (de) 2012-01-15
WO2006050414A2 (en) 2006-05-11
US8030291B2 (en) 2011-10-04
EP1814596A4 (de) 2010-06-16
US20090186849A1 (en) 2009-07-23
EP1814596A2 (de) 2007-08-08
US20090186848A1 (en) 2009-07-23
US20060281701A1 (en) 2006-12-14
US8168604B2 (en) 2012-05-01
AU2005302155B2 (en) 2012-09-06
US20060205693A1 (en) 2006-09-14
US20090186847A1 (en) 2009-07-23
US8030292B2 (en) 2011-10-04
US7507196B2 (en) 2009-03-24
AU2005302155A1 (en) 2006-05-11

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