CA2582170A1 - Biological fluid filtration method and apparatus - Google Patents
Biological fluid filtration method and apparatus Download PDFInfo
- Publication number
- CA2582170A1 CA2582170A1 CA002582170A CA2582170A CA2582170A1 CA 2582170 A1 CA2582170 A1 CA 2582170A1 CA 002582170 A CA002582170 A CA 002582170A CA 2582170 A CA2582170 A CA 2582170A CA 2582170 A1 CA2582170 A1 CA 2582170A1
- Authority
- CA
- Canada
- Prior art keywords
- fluid
- gas inlet
- inlet
- outlet
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000001914 filtration Methods 0.000 title claims abstract 28
- 239000013060 biological fluid Substances 0.000 title claims abstract 8
- 239000012530 fluid Substances 0.000 claims abstract 51
- 238000011144 upstream manufacturing Methods 0.000 claims abstract 23
- 210000000265 leukocyte Anatomy 0.000 claims 23
- 210000004369 blood Anatomy 0.000 claims 12
- 239000008280 blood Substances 0.000 claims 12
- 230000014759 maintenance of location Effects 0.000 claims 4
- 230000001580 bacterial effect Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 239000007789 gas Substances 0.000 abstract 5
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- External Artificial Organs (AREA)
Abstract
A biological fluid processing or fluid filtration system is provided having novel open and closed loop processing systems (44) wherein the gases transferred into and out of the system (55) during processing pass through a porous medium (67) in upstream and/or downstream gas inlet or outlet housings or vents (64, 71) in a manner which precludes the fluid being processed or filtered from ever contacting the housings or vents (64, 71). Each housing or vent (64, 71) is separated from the fluid by a column of gas in its respective transfer line (50, 54). The upstream gas inlet housing or vent (64) is in communication with the unfiltered biological fluid, and the downstream gas inlet housing or vent (71) is in communication with the filtered biological fluid.
Claims (20)
1. A closed loop leukocyte depletion system including:
a) a leukocyte depletion device having an inlet and an outlet, b) a blood container upstream from, and elevated above, said leukocyte depletion device and having an outlet, c) a first conduit in fluid communication with the outlet of said blood container and the inlet of said leukocyte depletion device, d) a receiving container downstream of said leukocyte depletion device and having an inlet, e) a second conduit in fluid communication with the inlet of said receiving container and the outlet of said leukocyte depletion device, f) a bypass line in fluid communication with said blood container and said receiving container and having a loop portion elevated above said blood container.
a) a leukocyte depletion device having an inlet and an outlet, b) a blood container upstream from, and elevated above, said leukocyte depletion device and having an outlet, c) a first conduit in fluid communication with the outlet of said blood container and the inlet of said leukocyte depletion device, d) a receiving container downstream of said leukocyte depletion device and having an inlet, e) a second conduit in fluid communication with the inlet of said receiving container and the outlet of said leukocyte depletion device, f) a bypass line in fluid communication with said blood container and said receiving container and having a loop portion elevated above said blood container.
2. The system defined in claim 1, wherein said bypass line is in fluid communication with said blood container proximate the bottom thereof and said conduit, and has a loop portion elevated above said blood container.
3. A leukocyte depletion system including:
a) a leukocyte depletion device having an inlet and an outlet, b) a blood container upstream from, and elevated above, said leukocyte depletion device and having an outlet, c) a first conduit in fluid communication with the outlet of said blood container and the inlet of said leukocyte depletion device, d) a receiving container downstream of said leukocyte depletion device and having an inlet, e) a second conduit in fluid communication with the inlet of said receiving container and the outlet of said leukocyte depletion device, f) an upstream gas inlet, a portion of which is located at a sufficient height so that the biological fluid being filtered does not contact a layer of a porous medium located in an upstream gas inlet housing connected to said upstream gas inlet, g) a downstream gas inlet elevated above said blood container, and in fluid communication with said leukocyte depletion device, and h) an upstream gas inlet housing connected to said upstream gas inlet, said upstream gas inlet housing including:
i) at least one layer of a porous medium interposed between an inlet and an outlet of said housing.
a) a leukocyte depletion device having an inlet and an outlet, b) a blood container upstream from, and elevated above, said leukocyte depletion device and having an outlet, c) a first conduit in fluid communication with the outlet of said blood container and the inlet of said leukocyte depletion device, d) a receiving container downstream of said leukocyte depletion device and having an inlet, e) a second conduit in fluid communication with the inlet of said receiving container and the outlet of said leukocyte depletion device, f) an upstream gas inlet, a portion of which is located at a sufficient height so that the biological fluid being filtered does not contact a layer of a porous medium located in an upstream gas inlet housing connected to said upstream gas inlet, g) a downstream gas inlet elevated above said blood container, and in fluid communication with said leukocyte depletion device, and h) an upstream gas inlet housing connected to said upstream gas inlet, said upstream gas inlet housing including:
i) at least one layer of a porous medium interposed between an inlet and an outlet of said housing.
4. The leukocyte depletion system defined in claim 3, and further including:
a) a downstream gas inlet housing connected to said downstream gas inlet, said downstream gas inlet housing including:
i) at least one layer of a second porous medium interposed between an inlet and an outlet of said housing.
a) a downstream gas inlet housing connected to said downstream gas inlet, said downstream gas inlet housing including:
i) at least one layer of a second porous medium interposed between an inlet and an outlet of said housing.
5. The leukocyte depletion system defined in claim 3, wherein said upstream gas inlet includes a loop portion to prevent gas entry into said leukocyte depletion system until substantially all of the biological fluid being processed has drained from said biological fluid container.
6. A leukocyte depletion system including:
a) a leukocyte depletion device having an inlet and an outlet, b) a blood container upstream from, and elevated above, said leukocyte depletion device and having an outlet, C) a first conduit in fluid communication with the outlet of said blood container and the inlet of said leukocyte depletion device, d) a receiving container downstream of said leukocyte depletion device and having an inlet, e) a second conduit in fluid communication with the inlet of said receiving container and the outlet of said leukocyte depletion device, f) an upstream gas inlet, a portion of which is located at a sufficient height so that the biological fluid being filtered does not contact a layer of a porous medium located in an upstream gas inlet housing connected to said upstream gas inlet, blood container, and in fluid communication with said leukocyte depletion device, and g) an upstream gas inlet housing connected to said upstream gas inlet, said upstream gas inlet housing including:
i) at least one layer of a porous medium interposed between an inlet and an outlet of said housing.
a) a leukocyte depletion device having an inlet and an outlet, b) a blood container upstream from, and elevated above, said leukocyte depletion device and having an outlet, C) a first conduit in fluid communication with the outlet of said blood container and the inlet of said leukocyte depletion device, d) a receiving container downstream of said leukocyte depletion device and having an inlet, e) a second conduit in fluid communication with the inlet of said receiving container and the outlet of said leukocyte depletion device, f) an upstream gas inlet, a portion of which is located at a sufficient height so that the biological fluid being filtered does not contact a layer of a porous medium located in an upstream gas inlet housing connected to said upstream gas inlet, blood container, and in fluid communication with said leukocyte depletion device, and g) an upstream gas inlet housing connected to said upstream gas inlet, said upstream gas inlet housing including:
i) at least one layer of a porous medium interposed between an inlet and an outlet of said housing.
7. A fluid filtration system including:
a) a filtration device, said filtration device having a filter media dividing said filtration device into an upstream side and a downstream side, b) a storage container for holding filtered fluid, C) a second conduit connected between the downstream side of said filtration device and said storage container, and d) a second vent line in fluid communication with the downstream side of said filtration device and selectively open to atmosphere.
a) a filtration device, said filtration device having a filter media dividing said filtration device into an upstream side and a downstream side, b) a storage container for holding filtered fluid, C) a second conduit connected between the downstream side of said filtration device and said storage container, and d) a second vent line in fluid communication with the downstream side of said filtration device and selectively open to atmosphere.
8. The fluid filtration system defined in claim 7, and further including:
a) a downstream gas inlet in fluid communication with said second vent line.
a) a downstream gas inlet in fluid communication with said second vent line.
9. The fluid filtration system defined in claim 8, wherein said downstream gas inlet includes:
a) an inlet open to atmosphere, b) an outlet connected to said second vent line, and c) at least one layer of a porous medium interposed between said inlet and said outlet.
a) an inlet open to atmosphere, b) an outlet connected to said second vent line, and c) at least one layer of a porous medium interposed between said inlet and said outlet.
10. The fluid filtration system defined in claim 9, wherein said downstream gas inlet further includes:
a) a cap for the selective opening and closing of said inlet.
a) a cap for the selective opening and closing of said inlet.
11. The fluid filtration system defined in claim 10, wherein said at least one layer of a porous medium is a bacterial retention medium.
12. The fluid filtration system defined in claim 10, wherein said as least one layer of a porous medium is a viral retention medium.
13. A fluid filtration system including:
a) a fluid container, b) a first conduit in fluid communication with said fluid container, c) a vent line in fluid communication with said first conduit and having an outlet at a sufficient height so that a fluid being filtered does not exit, and having a portion which prevents gas entry into said fluid filtration system until a desired amount of fluid has exited said fluid container.
a) a fluid container, b) a first conduit in fluid communication with said fluid container, c) a vent line in fluid communication with said first conduit and having an outlet at a sufficient height so that a fluid being filtered does not exit, and having a portion which prevents gas entry into said fluid filtration system until a desired amount of fluid has exited said fluid container.
14. The fluid filtration system defined in claim 13, and further including:
a) an upstream gas inlet housing in fluid communication with said vent line.
a) an upstream gas inlet housing in fluid communication with said vent line.
15. The fluid filtration system defined in claim 14, wherein said gas inlet housing includes:
a) an inlet open to atmosphere, b) an outlet connected to said vent line, and c) at least one layer of a porous medium interposed between said inlet and said outlet.
a) an inlet open to atmosphere, b) an outlet connected to said vent line, and c) at least one layer of a porous medium interposed between said inlet and said outlet.
16. The fluid filtration system defined in claim 15, wherein said at least one layer of a porous medium is a bacterial retention medium.
17. The fluid filtration system defined in claim 15, wherein said at least one layer of a porous medium is a viral retention medium.
18. A fluid filtration system including:
a) a filtration device, said filtration device having a filter media dividing said filtration device into an upstream side and a downstream side, b) a storage container for holding filterd fluid, c) a second conduit connected between the downstream side of said filtration device and said storage container, and d) a second vent line in fluid communication with the downstream side of said filtration device and selectively open to atmosphere.
a) a filtration device, said filtration device having a filter media dividing said filtration device into an upstream side and a downstream side, b) a storage container for holding filterd fluid, c) a second conduit connected between the downstream side of said filtration device and said storage container, and d) a second vent line in fluid communication with the downstream side of said filtration device and selectively open to atmosphere.
19. The fluid filtration system defined in claim 18, and further including:
a) a fluid container, b) a first conduit in fluid communication with said fluid container, c) a vent line in fluid communication with said first conduit and having an outlet at a sufficient height so that a fluid being filtered does not exit, and having a portion which prevents gas entry into said fluid filtration system until a desired amount of fluid has exited said fluid container.
a) a fluid container, b) a first conduit in fluid communication with said fluid container, c) a vent line in fluid communication with said first conduit and having an outlet at a sufficient height so that a fluid being filtered does not exit, and having a portion which prevents gas entry into said fluid filtration system until a desired amount of fluid has exited said fluid container.
20. The fluid filtration system defined in claim 19, and further including:
a) an upstream gas inlet housing in fluid communication with said vent line, b) a downstream gas inlet housing in fluid communication with said second vent line, said upstream gas inlet housing and said downstream gas inlet housing contained in a single inlet device.
a) an upstream gas inlet housing in fluid communication with said vent line, b) a downstream gas inlet housing in fluid communication with said second vent line, said upstream gas inlet housing and said downstream gas inlet housing contained in a single inlet device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2707745A CA2707745C (en) | 1998-03-20 | 1999-03-19 | Biological fluid filtration method and apparatus |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7884898P | 1998-03-20 | 1998-03-20 | |
| US60/078,848 | 1998-03-20 | ||
| US8348498P | 1998-04-29 | 1998-04-29 | |
| US60/083,484 | 1998-04-29 | ||
| CA002327665A CA2327665C (en) | 1998-03-20 | 1999-03-19 | Biological fluid filtration method and apparatus |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002327665A Division CA2327665C (en) | 1998-03-20 | 1999-03-19 | Biological fluid filtration method and apparatus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2707745A Division CA2707745C (en) | 1998-03-20 | 1999-03-19 | Biological fluid filtration method and apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2582170A1 true CA2582170A1 (en) | 1999-09-23 |
| CA2582170C CA2582170C (en) | 2010-09-21 |
Family
ID=38236348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2582170A Expired - Fee Related CA2582170C (en) | 1998-03-20 | 1999-03-19 | Biological fluid filtration method and apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2582170C (en) |
-
1999
- 1999-03-19 CA CA2582170A patent/CA2582170C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2582170C (en) | 2010-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150319 |