CA2561784A1 - Implantable delivery device with self adjustable exit port - Google Patents

Implantable delivery device with self adjustable exit port Download PDF

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Publication number
CA2561784A1
CA2561784A1 CA002561784A CA2561784A CA2561784A1 CA 2561784 A1 CA2561784 A1 CA 2561784A1 CA 002561784 A CA002561784 A CA 002561784A CA 2561784 A CA2561784 A CA 2561784A CA 2561784 A1 CA2561784 A1 CA 2561784A1
Authority
CA
Canada
Prior art keywords
slit
beneficial agent
chamber
flow
delivery device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002561784A
Other languages
French (fr)
Other versions
CA2561784C (en
Inventor
James E. Brown
Keith E. Dionne
Juan C. Gumucio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intarcia Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from CA002284929A external-priority patent/CA2284929C/en
Publication of CA2561784A1 publication Critical patent/CA2561784A1/en
Application granted granted Critical
Publication of CA2561784C publication Critical patent/CA2561784C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • External Artificial Organs (AREA)

Abstract

A delivery device having a first chamber containing an osmotic agent, a membrane forming a wall of the first chamber through which fluid is imbibed by osmosis, a second chamber containing a beneficial agent to be delivered, and a moveable piston separating the two chambers. In fluid communication with the second chamber is an orifice which comprises a slit valve. In the presence of pressure, the beneficial agent pushes through the slit, opening up a channel for delivery of the beneficial agent and creating flow. Because the slit remains closed in the absence of flow (or when the pressure is below the pressure required to open the slit), back diffusion of external fluids is eliminated when the slit is closed, which prevents contamination of the beneficial agent in the second chamber by external fluids. In addition, forward diffusion of the beneficial agent out of the capsule is prevented when the slit is closed. The slit valve opens only to the minimum dimension required to allow the flow generated by the osmostic pumping rate. The slit valve also allows a flow path to open around any obstruction in the slit valve to prevent clogging.
CA002561784A 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port Expired - Fee Related CA2561784C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3560797P 1997-03-24 1997-03-24
US60/035,607 1997-03-24
CA002284929A CA2284929C (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002284929A Division CA2284929C (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port

Publications (2)

Publication Number Publication Date
CA2561784A1 true CA2561784A1 (en) 1998-10-01
CA2561784C CA2561784C (en) 2008-01-15

Family

ID=37450531

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002561784A Expired - Fee Related CA2561784C (en) 1997-03-24 1998-03-10 Implantable delivery device with self adjustable exit port

Country Status (1)

Country Link
CA (1) CA2561784C (en)

Also Published As

Publication number Publication date
CA2561784C (en) 2008-01-15

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed