CA2557301A1 - Cyclobutenedione groups-containing compounds as inhibitors of hepatitis c virus ns3 serine protease - Google Patents
Cyclobutenedione groups-containing compounds as inhibitors of hepatitis c virus ns3 serine protease Download PDFInfo
- Publication number
- CA2557301A1 CA2557301A1 CA002557301A CA2557301A CA2557301A1 CA 2557301 A1 CA2557301 A1 CA 2557301A1 CA 002557301 A CA002557301 A CA 002557301A CA 2557301 A CA2557301 A CA 2557301A CA 2557301 A1 CA2557301 A1 CA 2557301A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- group
- alkyl
- hcv
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 CC(C)C(C(C1=O)=O)=C1N(C)C[C@@](C(C)(C)C)NC(N[C@@](C(C)(C)C)C(N(C[C@@](C1)*(C)C)[C@@]1C(NC(CC1CC1)C(C(N*)=O)=O)=O)=O)=O Chemical compound CC(C)C(C(C1=O)=O)=C1N(C)C[C@@](C(C)(C)C)NC(N[C@@](C(C)(C)C)C(N(C[C@@](C1)*(C)C)[C@@]1C(NC(CC1CC1)C(C(N*)=O)=O)=O)=O)=O 0.000 description 2
- NTUBTQQUFMODES-QHSCAFSZSA-N CC(C)(C)[C@@H](CNC(C1=O)=C(C2CC2)C1=O)NC(N[C@@H](C(C)(C)C)C(N(CC1)C(C(NC(CC2CCC2)C(C(N)=O)=O)=O)C1=[F](C)C)=O)=O Chemical compound CC(C)(C)[C@@H](CNC(C1=O)=C(C2CC2)C1=O)NC(N[C@@H](C(C)(C)C)C(N(CC1)C(C(NC(CC2CCC2)C(C(N)=O)=O)=O)C1=[F](C)C)=O)=O NTUBTQQUFMODES-QHSCAFSZSA-N 0.000 description 1
- UPWXQYRODBSCDQ-BJYQXZSCSA-N CC(C)C[C@@H](CC1)[C@@H](C(NCC(C(NC)=O)=O)=O)N1C([C@H](C(C)(C)C)NC(N[C@H](CNC(C(C1=O)=O)=C1N(C)C)C(C)(C)C)=O)=O Chemical compound CC(C)C[C@@H](CC1)[C@@H](C(NCC(C(NC)=O)=O)=O)N1C([C@H](C(C)(C)C)NC(N[C@H](CNC(C(C1=O)=O)=C1N(C)C)C(C)(C)C)=O)=O UPWXQYRODBSCDQ-BJYQXZSCSA-N 0.000 description 1
- RFYBHBJEITZLDH-IPTNVUIUSA-N CC(C)[C@H](C[C@H]1C(NC(CCC#C)C(C(NCC=C)=O)=O)=O)CN1C([C@H](C1CCCCC1)NC(N[C@H](CN(C)C(C(C1=O)=O)=C1N(C)C)C1CCCCC1)=O)=O Chemical compound CC(C)[C@H](C[C@H]1C(NC(CCC#C)C(C(NCC=C)=O)=O)=O)CN1C([C@H](C1CCCCC1)NC(N[C@H](CN(C)C(C(C1=O)=O)=C1N(C)C)C1CCCCC1)=O)=O RFYBHBJEITZLDH-IPTNVUIUSA-N 0.000 description 1
- GYCSZGRZZMAWPH-SANXVGBMSA-N CCCC(C(C(NCC=C)=O)=O)NC([C@H](C[C@H](C1)/C(/C)=C/C)N1C([C@H](C1CCCCC1)NC(N[C@H](CN(C)C(C1=O)=C(C2(C)CC2)C1=O)C(C)(C)C)=O)=O)=O Chemical compound CCCC(C(C(NCC=C)=O)=O)NC([C@H](C[C@H](C1)/C(/C)=C/C)N1C([C@H](C1CCCCC1)NC(N[C@H](CN(C)C(C1=O)=C(C2(C)CC2)C1=O)C(C)(C)C)=O)=O)=O GYCSZGRZZMAWPH-SANXVGBMSA-N 0.000 description 1
- XSDRDPJXSVKKQN-HBAIKHLUSA-N CCCC(C(C(NCC=C)=O)=O)NC([C@H]([C@H](CC1)C(C)C)N1C([C@H](C(C)(C)C)NC(N[C@H](CCCC(CC)C(C1=O)=C(C)C1=O)C(C)(C)C)=O)=O)O Chemical compound CCCC(C(C(NCC=C)=O)=O)NC([C@H]([C@H](CC1)C(C)C)N1C([C@H](C(C)(C)C)NC(N[C@H](CCCC(CC)C(C1=O)=C(C)C1=O)C(C)(C)C)=O)=O)O XSDRDPJXSVKKQN-HBAIKHLUSA-N 0.000 description 1
- ZDFFDVBMVFQQOP-MYWVDXEWSA-N CCNC(C(C(CC1CC1)NC([C@H]1N(C[C@H](C(C)(C)C)NC(N[C@H](CN(C)C(C(C2=O)=O)=C2N(C)C)C(C)(C)C)=O)CCC1C(C)C)=O)=O)=O Chemical compound CCNC(C(C(CC1CC1)NC([C@H]1N(C[C@H](C(C)(C)C)NC(N[C@H](CN(C)C(C(C2=O)=O)=C2N(C)C)C(C)(C)C)=O)CCC1C(C)C)=O)=O)=O ZDFFDVBMVFQQOP-MYWVDXEWSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54842304P | 2004-02-27 | 2004-02-27 | |
| US60/548,423 | 2004-02-27 | ||
| PCT/US2005/006083 WO2005085197A1 (en) | 2004-02-27 | 2005-02-24 | Cyclobutenedione groups-containing compounds as inhibitors of hepatitis c virus ns3 serine protease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2557301A1 true CA2557301A1 (en) | 2005-09-15 |
Family
ID=34919362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002557301A Abandoned CA2557301A1 (en) | 2004-02-27 | 2005-02-24 | Cyclobutenedione groups-containing compounds as inhibitors of hepatitis c virus ns3 serine protease |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1742914A1 (https=) |
| JP (1) | JP2007525521A (https=) |
| CN (1) | CN1946690A (https=) |
| CA (1) | CA2557301A1 (https=) |
| WO (1) | WO2005085197A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060281689A1 (en) * | 2005-06-02 | 2006-12-14 | Schering Corporation | Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period |
| US20060276404A1 (en) * | 2005-06-02 | 2006-12-07 | Anima Ghosal | Medicaments and methods combining a HCV protease inhibitor and an AKR competitor |
| US20070021351A1 (en) * | 2005-06-02 | 2007-01-25 | Schering Corporation | Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor |
| AU2006252623A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation useful for treating disorders associated with hepatitis C virus |
| US20060276407A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis C virus |
| WO2006130552A2 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Methods of treating hepatitis c virus |
| US20060275366A1 (en) * | 2005-06-02 | 2006-12-07 | Schering Corporation | Controlled-release formulation |
| UA96283C2 (uk) | 2005-12-23 | 2011-10-25 | Зіланд Фарма А/С | Модифіковані міметики лізину |
| US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| JP2010500978A (ja) | 2006-08-17 | 2010-01-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼインヒビター |
| EP2074087A2 (en) | 2006-12-21 | 2009-07-01 | Wyeth | Synthesis of pyrrolidine compounds |
| CA2693997C (en) | 2007-08-03 | 2013-01-15 | Pierre L. Beaulieu | Viral polymerase inhibitors |
| CN101903351B (zh) | 2007-12-19 | 2014-09-10 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
| JP2012514605A (ja) | 2009-01-07 | 2012-06-28 | サイネクシス，インコーポレーテッド | Ｈｃｖおよびｈｉｖ感染の治療への使用におけるシクロスポリン誘導体 |
| CN103387510B (zh) * | 2013-08-08 | 2015-09-09 | 苏州永健生物医药有限公司 | 一种β-氨基-alpha-羟基环丁基丁酰胺盐酸盐的合成方法 |
| CN110709096B (zh) | 2017-05-05 | 2023-10-31 | 泽兰德制药公司 | 细胞间隙连接通讯调节剂及其在糖尿病性眼病治疗中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5168103A (en) * | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| UA74546C2 (en) * | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
| ES2240446T3 (es) * | 2000-04-03 | 2005-10-16 | Vertex Pharma | Inhibidores de serina proteasas, particularmente la proteasa ns3 del virus de la hepatitis c. |
| DK1385870T3 (da) * | 2000-07-21 | 2010-07-05 | Schering Corp | Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus |
| US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| KR20030081297A (ko) * | 2000-07-21 | 2003-10-17 | 쉐링 코포레이션 | Ｃ형 간염 바이러스의 ｎｓ3-세린 프로테아제억제제로서의 신규한 펩티드 |
| WO2002062761A1 (en) * | 2001-02-07 | 2002-08-15 | Abbott Laboratories | Aminal diones as potassium channel openers |
| US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| CN1289471C (zh) * | 2001-04-16 | 2006-12-13 | 先灵公司 | 作为cxc－趋化因子受体配体的3,4－二取代的环丁烯－1,2－二酮 |
-
2005
- 2005-02-24 EP EP05723791A patent/EP1742914A1/en not_active Withdrawn
- 2005-02-24 CA CA002557301A patent/CA2557301A1/en not_active Abandoned
- 2005-02-24 WO PCT/US2005/006083 patent/WO2005085197A1/en not_active Ceased
- 2005-02-24 CN CNA2005800126511A patent/CN1946690A/zh active Pending
- 2005-02-24 JP JP2007501006A patent/JP2007525521A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1946690A (zh) | 2007-04-11 |
| WO2005085197A1 (en) | 2005-09-15 |
| EP1742914A1 (en) | 2007-01-17 |
| JP2007525521A (ja) | 2007-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |
Effective date: 20130225 |