CA2548972A1 - Treatment of mammals by sirna delivery into mammalian nerve cells - Google Patents
Treatment of mammals by sirna delivery into mammalian nerve cells Download PDFInfo
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- CA2548972A1 CA2548972A1 CA002548972A CA2548972A CA2548972A1 CA 2548972 A1 CA2548972 A1 CA 2548972A1 CA 002548972 A CA002548972 A CA 002548972A CA 2548972 A CA2548972 A CA 2548972A CA 2548972 A1 CA2548972 A1 CA 2548972A1
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- bdnf
- sirna
- hypoxia
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
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Landscapes
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- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52932603P | 2003-12-12 | 2003-12-12 | |
| US60/529,326 | 2003-12-12 | ||
| PCT/US2004/041339 WO2005059135A2 (en) | 2003-12-12 | 2004-12-10 | Treatment of mammals by sirna delivery into mammalian nerve cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2548972A1 true CA2548972A1 (en) | 2005-06-30 |
Family
ID=34699962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002548972A Abandoned CA2548972A1 (en) | 2003-12-12 | 2004-12-10 | Treatment of mammals by sirna delivery into mammalian nerve cells |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20050234000A1 (https=) |
| EP (1) | EP1708756A2 (https=) |
| JP (1) | JP2007513968A (https=) |
| CA (1) | CA2548972A1 (https=) |
| WO (1) | WO2005059135A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2553261C (en) | 2004-01-16 | 2014-03-18 | Stefan Barth | Immunokinases |
| MX2007002423A (es) * | 2004-08-31 | 2007-08-07 | Sylentis Sau | Metodos y composiciones para inhibir la expresion del receptor p2x7. |
| WO2006042396A1 (en) * | 2004-10-22 | 2006-04-27 | Universite Laval | Modulation of neuroglia-derived bdnf in the treatment and prevention of pain |
| EP1800695A1 (en) | 2005-12-21 | 2007-06-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Immuno-RNA-constructs |
| US8530436B2 (en) * | 2007-01-29 | 2013-09-10 | Transderm, Inc. | Methods and compositions for transdermal delivery of nucleotides |
| US20120322861A1 (en) | 2007-02-23 | 2012-12-20 | Barry John Byrne | Compositions and Methods for Treating Diseases |
| EP2132309A4 (en) * | 2007-02-23 | 2011-01-05 | Univ Florida | COMPOSITIONS AND METHODS OF TREATING GLYCOLOGICAL MEMORY DISEASES |
| FR2921935B1 (fr) * | 2007-10-05 | 2011-10-28 | Centre Nat Rech Scient | Procede de criblage de composes utilisables pour le traitement de troubles respiratoires |
| US9265843B2 (en) | 2008-03-27 | 2016-02-23 | The Ohio State University | Treatment of metabolic-related disorders using hypothalamic gene transfer of BDNF and compositions therefor |
| WO2010051532A1 (en) * | 2008-10-31 | 2010-05-06 | University Of Chicago | Compositions and methods related to obstructive sleep apnea |
| CA2756670A1 (en) * | 2009-03-26 | 2010-09-30 | The Regents Of The University Of California | Mesenchymal stem cells producing inhibitory rna for disease modification |
| WO2012142622A1 (en) * | 2011-04-15 | 2012-10-18 | Molecular Transfer, Inc. | Agents for improved delivery of nucleic acids to eukaryotic cells |
| KR20150020250A (ko) | 2012-06-19 | 2015-02-25 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 당뇨병을 치료하기 위한 조성물 및 방법 |
| EP2986599A1 (en) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| CN116942825A (zh) * | 2023-07-21 | 2023-10-27 | 南通大学 | Cda基因在制备治疗神经轴突损伤相关疾病药物中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6265387B1 (en) * | 1995-10-11 | 2001-07-24 | Mirus, Inc. | Process of delivering naked DNA into a hepatocyte via bile duct |
| EP0969875B1 (en) * | 1997-01-17 | 2008-11-26 | Aventis Pharma S.A. | Naked dna-mediated gene transfer into medullary motor neurons |
| CA2429814C (en) * | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
-
2004
- 2004-12-10 JP JP2006544003A patent/JP2007513968A/ja not_active Abandoned
- 2004-12-10 WO PCT/US2004/041339 patent/WO2005059135A2/en not_active Ceased
- 2004-12-10 US US11/009,797 patent/US20050234000A1/en not_active Abandoned
- 2004-12-10 CA CA002548972A patent/CA2548972A1/en not_active Abandoned
- 2004-12-10 EP EP04813641A patent/EP1708756A2/en not_active Withdrawn
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2008
- 2008-01-10 US US11/972,376 patent/US20090186844A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090186844A1 (en) | 2009-07-23 |
| WO2005059135A2 (en) | 2005-06-30 |
| US20050234000A1 (en) | 2005-10-20 |
| JP2007513968A (ja) | 2007-05-31 |
| WO2005059135A3 (en) | 2005-08-18 |
| EP1708756A2 (en) | 2006-10-11 |
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