CA2548539A1 - Method and apparatus for multiplexing plural ion beams to a mass spectrometer - Google Patents
Method and apparatus for multiplexing plural ion beams to a mass spectrometer Download PDFInfo
- Publication number
- CA2548539A1 CA2548539A1 CA002548539A CA2548539A CA2548539A1 CA 2548539 A1 CA2548539 A1 CA 2548539A1 CA 002548539 A CA002548539 A CA 002548539A CA 2548539 A CA2548539 A CA 2548539A CA 2548539 A1 CA2548539 A1 CA 2548539A1
- Authority
- CA
- Canada
- Prior art keywords
- ion
- mass spectrometer
- traps
- ions
- trap
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000010884 ion-beam technique Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000002500 ions Chemical class 0.000 claims abstract 52
- 238000005040 ion trap Methods 0.000 claims abstract 39
- 230000005540 biological transmission Effects 0.000 claims abstract 2
- 230000005405 multipole Effects 0.000 claims 4
- 239000013626 chemical specie Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 230000002123 temporal effect Effects 0.000 claims 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 1
- 239000002131 composite material Substances 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 238000003795 desorption Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 238000009616 inductively coupled plasma Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000005192 partition Methods 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 230000001360 synchronised effect Effects 0.000 claims 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/107—Arrangements for using several ion sources
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
A method/apparatus for multiplexing plural ion beams to a mass spectrometer. At least two ion sources are provided with means of transporting the ions fr om the ion sources to separate two-dimensional ion traps. Each ion trap is used for storage and transmission of the ions and operates between the ion source s and the mass analyzer. Each ion trap has a set of equally spaced, parallel multipode rods, as well as entrance and exit sections into which and from which ions enter and exit the trap, respectively. For each ion trap, the entrance section is placed in a region where background has pressure is at viscous flow. The pressure at the exit section drops to molecular flow pressure regimes without a break in the structure of the ion trap. Each trap alternately stores and transmits ions by way of a fast voltage switch applie d to the ion trap exit lens.
Claims (33)
1. ~An apparatus for analyzing chemical species, comprising:
(a) at least two ion sources;
(b) means of transporting said ions from each of said ion sources to separate two dimensional ion traps, (c) each of said two-dimensional ion traps being used for storage and transmission of said ions from each of the said ion sources, (d) all of said ion traps operating between said ion sources and said mass analyzer, (e) all of said ion traps having a set of equally spaced, parallel, multipole rods, (f) all of said ion traps having an ion entrance section where said ions enter said ion trap and an ion exit section where said ions exit said ion trap, (g) all of said ion trap being positioned such that said ion entrance section is placed in a region where background gas pressure is at viscous flow, and such that the pressure along said ion trap at said ion exit section drops to molecular flow pressure regimes without a break in the structure of said ion trap, (h) each of said ion traps being made to alternately store and transmit ions by using a fast voltage switching device to switch voltage levels of said ion trap exit lens, (i) all of said ion traps being operated in a synchronized manner to ensure that the detected chemical species detected by said mass analyzer be correctly and unequivocally associated with its respective ion source, (j) a mass analyzer and detector;
(k) said detector with which said ions from each of said ion sources are serially mass analyzed, (l) ~said detector being coupled to a data acquisition system which can distinguish which signals arise from which said ion source, (m)~an accurate timing device that controls said voltage switching devices for synchronizing said voltage levels of said ion traps exit lenses with a mass analyzer, and which determines the respective voltage levels, durations and time delays of said voltage levels of said ion trap exit lenses and said mass analyzer to each other.
(a) at least two ion sources;
(b) means of transporting said ions from each of said ion sources to separate two dimensional ion traps, (c) each of said two-dimensional ion traps being used for storage and transmission of said ions from each of the said ion sources, (d) all of said ion traps operating between said ion sources and said mass analyzer, (e) all of said ion traps having a set of equally spaced, parallel, multipole rods, (f) all of said ion traps having an ion entrance section where said ions enter said ion trap and an ion exit section where said ions exit said ion trap, (g) all of said ion trap being positioned such that said ion entrance section is placed in a region where background gas pressure is at viscous flow, and such that the pressure along said ion trap at said ion exit section drops to molecular flow pressure regimes without a break in the structure of said ion trap, (h) each of said ion traps being made to alternately store and transmit ions by using a fast voltage switching device to switch voltage levels of said ion trap exit lens, (i) all of said ion traps being operated in a synchronized manner to ensure that the detected chemical species detected by said mass analyzer be correctly and unequivocally associated with its respective ion source, (j) a mass analyzer and detector;
(k) said detector with which said ions from each of said ion sources are serially mass analyzed, (l) ~said detector being coupled to a data acquisition system which can distinguish which signals arise from which said ion source, (m)~an accurate timing device that controls said voltage switching devices for synchronizing said voltage levels of said ion traps exit lenses with a mass analyzer, and which determines the respective voltage levels, durations and time delays of said voltage levels of said ion trap exit lenses and said mass analyzer to each other.
2. An apparatus according to claim 1, wherein said ion sources operate at substantially atmospheric pressure.
3. An apparatus according to claim 1, wherein said ion sources operate at sub-atmospheric pressure.
4. An apparatus according to claim 2, wherein said ion sources include at least one electrospray ion source.
5. An apparatus according to claim 4, wherein said electrospray ion source is a micro-electrospray ion source.
6. An apparatus according to claim 5, wherein said micro-electrospray ion source operates at liquid flowrate of less than 1 microliter per minute.
7. An apparatus according to claim 2, wherein said ion sources include at least one atmospheric pressure chemical ionization source.
8. An apparatus according to claim 2, wherein said ion sources include at least one inductively coupled plasma ion source.
9. An apparatus according to claim 3, wherein said ion sources include at least one electron impact ion source.
10. An apparatus according to claim 3, wherein said ion sources include at least glow discharge ion source.
11. An apparatus according to claim 3, wherein said ion sources include at least one matrix assisted laser desorption ion source.
12. An apparatus according to claim 1, wherein said mass analyzer is a time-of-flight mass spectrometer.
13. An apparatus according to claim 1, wherein said mass analyzer is an ion trap mass spectrometer.
14. An apparatus according to claim 1, wherein said mass analyzer is a Fourier Transform mass spectrometer.
15. An apparatus according to claim 1, wherein said mass analyzer is a tandem mass spectrometer.
16. An apparatus according to claim 12, wherein said time-of-flight mass spectrometer is an orthogonal time-of-flight mass spectrometer with a flight tube oriented perpendicular to the axis of the said ion traps.
17. An apparatus according to claim 12, wherein said time-of-flight mass spectrometer is an in-line time-of-flight mass spectrometer with a flight tube oriented parallel to the axis of the said ion traps.
18. An apparatus according to claim 12, wherein said time-of-flight mass spectrometer contains a reflectron to compensate for energy distribution of said ions.
19. An apparatus according to claim 13, wherein said ion trap mass spectrometer is a three dimensional ion trap mass spectrometer.
20. ~An apparatus according to claim 15, wherein said tandem mass spectrometer includes at least one time-of-flight mass spectrometer.
21. ~An apparatus according to claim 15, wherein said tandem mass spectrometer includes at least one ion trap mass spectrometer.
22. ~An apparatus according to claim 15, wherein said tandem mass spectrometer includes at least one Fourier Transform mass spectrometer.
23. ~An apparatus according to claim 1, wherein said data acquisition system associates the signal arising from a particular ion packet with a specific ion source using temporal encoding.
24. ~An apparatus according to claim 23, wherein said temporal encoding consists of a means of synchronizing ion pulses from each of the said ion traps with specific data acquisition channels which partition the data stream according to its ion source.
25. ~An apparatus according to claim 1, wherein said data acquisition system associates individual signals with specific ion sources using chemical encoding.
26. ~An apparatus according to claim 24, wherein said chemical encoding consists of a particular mass-to-charge species being present or absent in said signal.
27. ~An apparatus according to claim 1, wherein said ion traps are operated in such a manner that for the interval of time during which a said ion trap is forbidden to transmit ion packets to the mass analyzer, said ions entering said ion trap are substantially accumulated to preserve analytical sensitivity.
28. ~An apparatus according to claim 1, wherein one or more of said multipole ion traps is a quadrupole.
29. ~An apparatus according to claim 1, wherein one or more of said multipole ion traps is a hexapole.
30. ~An apparatus according to claim 1, wherein one or more of said multipole ion traps has more than six poles.
31. ~An apparatus according to claim 1, wherein said ion traps are operated in such a manner that a packet of said ions from no more than one said ion trap be permitted in the said mass analyzer at any given time.
32. ~An apparatus according to claim 1, wherein said ion traps are operated in such a manner that packets of said ions from two or more said ion traps be permitted in the said mass analyzer at any given time provided the individual mass-to-charge peaks within the composite signal can be clearly associated with its respective ion source unequivocally.
33. ~An apparatus according to claim 1, wherein the emitted ion packets intersect the extraction region of a time-of-flight mass spectrometer in a plane which is parallel to the said ion traps axis and perpendicular to the flight tube axis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2004/036448 WO2006049623A2 (en) | 2004-11-02 | 2004-11-02 | Method and apparatus for multiplexing plural ion beams to a mass spectrometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2548539A1 true CA2548539A1 (en) | 2006-05-11 |
| CA2548539C CA2548539C (en) | 2010-05-11 |
Family
ID=36319582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2548539A Active CA2548539C (en) | 2004-11-02 | 2004-11-02 | Method and apparatus for multiplexing plural ion beams to a mass spectrometer |
Country Status (2)
| Country | Link |
|---|---|
| CA (1) | CA2548539C (en) |
| WO (1) | WO2006049623A2 (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006040000B4 (en) | 2006-08-25 | 2010-10-28 | Bruker Daltonik Gmbh | Storage battery for ions |
| US9786484B2 (en) | 2014-05-16 | 2017-10-10 | Leco Corporation | Method and apparatus for decoding multiplexed information in a chromatographic system |
| GB201613988D0 (en) | 2016-08-16 | 2016-09-28 | Micromass Uk Ltd And Leco Corp | Mass analyser having extended flight path |
| GB2567794B (en) | 2017-05-05 | 2023-03-08 | Micromass Ltd | Multi-reflecting time-of-flight mass spectrometers |
| GB2563571B (en) | 2017-05-26 | 2023-05-24 | Micromass Ltd | Time of flight mass analyser with spatial focussing |
| WO2019030472A1 (en) | 2017-08-06 | 2019-02-14 | Anatoly Verenchikov | Ion mirror for multi-reflecting mass spectrometers |
| EP3662503A1 (en) | 2017-08-06 | 2020-06-10 | Micromass UK Limited | Ion injection into multi-pass mass spectrometers |
| WO2019030473A1 (en) | 2017-08-06 | 2019-02-14 | Anatoly Verenchikov | Fields for multi-reflecting tof ms |
| US11817303B2 (en) | 2017-08-06 | 2023-11-14 | Micromass Uk Limited | Accelerator for multi-pass mass spectrometers |
| EP3662502A1 (en) | 2017-08-06 | 2020-06-10 | Micromass UK Limited | Printed circuit ion mirror with compensation |
| WO2019030475A1 (en) | 2017-08-06 | 2019-02-14 | Anatoly Verenchikov | Multi-pass mass spectrometer |
| US11081332B2 (en) | 2017-08-06 | 2021-08-03 | Micromass Uk Limited | Ion guide within pulsed converters |
| GB201806507D0 (en) | 2018-04-20 | 2018-06-06 | Verenchikov Anatoly | Gridless ion mirrors with smooth fields |
| GB201807626D0 (en) | 2018-05-10 | 2018-06-27 | Micromass Ltd | Multi-reflecting time of flight mass analyser |
| GB201807605D0 (en) | 2018-05-10 | 2018-06-27 | Micromass Ltd | Multi-reflecting time of flight mass analyser |
| GB201808530D0 (en) | 2018-05-24 | 2018-07-11 | Verenchikov Anatoly | TOF MS detection system with improved dynamic range |
| GB201810573D0 (en) | 2018-06-28 | 2018-08-15 | Verenchikov Anatoly | Multi-pass mass spectrometer with improved duty cycle |
| GB201901411D0 (en) | 2019-02-01 | 2019-03-20 | Micromass Ltd | Electrode assembly for mass spectrometer |
| US20240071741A1 (en) | 2022-08-31 | 2024-02-29 | Thermo Fisher Scientific (Bremen) Gmbh | Electrostatic Ion Trap Configuration |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7019285B2 (en) * | 1995-08-10 | 2006-03-28 | Analytica Of Branford, Inc. | Ion storage time-of-flight mass spectrometer |
-
2004
- 2004-11-02 WO PCT/US2004/036448 patent/WO2006049623A2/en active Application Filing
- 2004-11-02 CA CA2548539A patent/CA2548539C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006049623A3 (en) | 2007-04-19 |
| WO2006049623A2 (en) | 2006-05-11 |
| CA2548539C (en) | 2010-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |