CA2547497C - Dispositif d'introduction courbe pour spectrometrie de masse - Google Patents
Dispositif d'introduction courbe pour spectrometrie de masse Download PDFInfo
- Publication number
- CA2547497C CA2547497C CA002547497A CA2547497A CA2547497C CA 2547497 C CA2547497 C CA 2547497C CA 002547497 A CA002547497 A CA 002547497A CA 2547497 A CA2547497 A CA 2547497A CA 2547497 C CA2547497 C CA 2547497C
- Authority
- CA
- Canada
- Prior art keywords
- probe
- curved
- electrospray
- tip
- probe tip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004949 mass spectrometry Methods 0.000 title description 5
- 239000000523 sample Substances 0.000 claims abstract description 538
- 150000002500 ions Chemical class 0.000 claims description 107
- 239000000243 solution Substances 0.000 claims description 103
- 239000007788 liquid Substances 0.000 claims description 95
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 49
- 238000002663 nebulization Methods 0.000 claims description 29
- 238000004811 liquid chromatography Methods 0.000 claims description 22
- 238000005251 capillar electrophoresis Methods 0.000 claims description 20
- 238000000926 separation method Methods 0.000 claims description 17
- 238000002347 injection Methods 0.000 claims description 9
- 239000007924 injection Substances 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 238000000132 electrospray ionisation Methods 0.000 claims description 6
- 238000005040 ion trap Methods 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 4
- 238000004587 chromatography analysis Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims 10
- 239000013626 chemical specie Substances 0.000 claims 5
- 239000012488 sample solution Substances 0.000 abstract description 16
- 239000010410 layer Substances 0.000 description 70
- 239000007789 gas Substances 0.000 description 58
- 239000007921 spray Substances 0.000 description 30
- 239000000203 mixture Substances 0.000 description 19
- 230000000712 assembly Effects 0.000 description 16
- 238000000429 assembly Methods 0.000 description 16
- 238000001819 mass spectrum Methods 0.000 description 14
- 238000005507 spraying Methods 0.000 description 11
- 239000006199 nebulizer Substances 0.000 description 9
- 239000012482 calibration solution Substances 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- 238000001704 evaporation Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000005484 gravity Effects 0.000 description 5
- 238000005457 optimization Methods 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000005684 electric field Effects 0.000 description 4
- 238000007787 electrohydrodynamic spraying Methods 0.000 description 4
- 239000005350 fused silica glass Substances 0.000 description 4
- 239000006193 liquid solution Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 238000000752 ionisation method Methods 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 238000001962 electrophoresis Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000006200 vaporizer Substances 0.000 description 2
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000005219 brazing Methods 0.000 description 1
- 238000000738 capillary electrophoresis-mass spectrometry Methods 0.000 description 1
- 150000001793 charged compounds Chemical class 0.000 description 1
- 238000000451 chemical ionisation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000010292 electrical insulation Methods 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000005405 multipole Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000005381 potential energy Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000005476 soldering Methods 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Landscapes
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6211797P | 1997-10-15 | 1997-10-15 | |
| US60/062,117 | 1997-10-15 | ||
| CA002306009A CA2306009C (fr) | 1997-10-15 | 1998-10-15 | Dispositif d'introduction courbe pour spectrometrie de masse |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002306009A Division CA2306009C (fr) | 1997-10-15 | 1998-10-15 | Dispositif d'introduction courbe pour spectrometrie de masse |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2547497A1 CA2547497A1 (fr) | 1999-04-22 |
| CA2547497C true CA2547497C (fr) | 2009-05-26 |
Family
ID=36930114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002547497A Expired - Lifetime CA2547497C (fr) | 1997-10-15 | 1998-10-15 | Dispositif d'introduction courbe pour spectrometrie de masse |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2547497C (fr) |
-
1998
- 1998-10-15 CA CA002547497A patent/CA2547497C/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2547497A1 (fr) | 1999-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20181015 |