CA2545717A1 - Anti-tumour terpene compounds - Google Patents
Anti-tumour terpene compounds Download PDFInfo
- Publication number
- CA2545717A1 CA2545717A1 CA002545717A CA2545717A CA2545717A1 CA 2545717 A1 CA2545717 A1 CA 2545717A1 CA 002545717 A CA002545717 A CA 002545717A CA 2545717 A CA2545717 A CA 2545717A CA 2545717 A1 CA2545717 A1 CA 2545717A1
- Authority
- CA
- Canada
- Prior art keywords
- cancer
- cells
- compound
- terpene
- bisabolene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 229940067606 lecithin Drugs 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000002879 macerating effect Effects 0.000 description 1
- 238000004890 malting Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000000346 nonvolatile oil Substances 0.000 description 1
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 108091011000 phospholipid binding proteins Proteins 0.000 description 1
- 102000036213 phospholipid binding proteins Human genes 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 229940100618 rectal suppository Drugs 0.000 description 1
- 239000006215 rectal suppository Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000012262 resinous product Substances 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 201000004409 schistosomiasis Diseases 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- 201000003708 skin melanoma Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0326518.8A GB0326518D0 (en) | 2003-11-13 | 2003-11-13 | Anti-cancer compounds |
| GB0326518.8 | 2003-11-13 | ||
| PCT/GB2004/004769 WO2005049001A1 (en) | 2003-11-13 | 2004-11-12 | Anti-tumour terpene compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2545717A1 true CA2545717A1 (en) | 2005-06-02 |
Family
ID=29726508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002545717A Abandoned CA2545717A1 (en) | 2003-11-13 | 2004-11-12 | Anti-tumour terpene compounds |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20070259056A1 (https=) |
| EP (1) | EP1682107B1 (https=) |
| JP (1) | JP2007511492A (https=) |
| KR (1) | KR20060121177A (https=) |
| CN (2) | CN1882319B (https=) |
| AT (1) | ATE439126T1 (https=) |
| AU (1) | AU2004290946B2 (https=) |
| CA (1) | CA2545717A1 (https=) |
| DE (1) | DE602004022578D1 (https=) |
| DK (1) | DK1682107T3 (https=) |
| GB (1) | GB0326518D0 (https=) |
| WO (1) | WO2005049001A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101849981B (zh) * | 2010-06-22 | 2011-11-23 | 南京中医药大学 | 一种具有抗妇科肿瘤作用的没药有效部位及其制备方法和其应用 |
| WO2012033634A2 (en) | 2010-09-09 | 2012-03-15 | Mary Kay Inc. | Topical skin care formulations comprising plant extracts |
| WO2018144954A1 (en) * | 2017-02-03 | 2018-08-09 | City Of Hope | Silica nanoparticle with an insoluble drug |
| WO2020033567A1 (en) * | 2018-08-07 | 2020-02-13 | University Of Florida Research Foundation | Methods and compositions for substituted arylcycloheptane analogs |
| CN110960518B (zh) * | 2019-12-31 | 2022-12-20 | 河南大学 | 金丝大菊提取物在制备抗肿瘤药物中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5190979A (en) * | 1988-06-24 | 1993-03-02 | Stephen Herman | Ozonides of terpenes and their medical uses |
| US6350784B1 (en) * | 1996-02-12 | 2002-02-26 | Meryl J. Squires | Antimicrobial prevention and treatment of human immunedeficiency virus and other infectious diseases |
| US5602184A (en) * | 1993-03-03 | 1997-02-11 | The United States Of America As Represented By Department Of Health And Human Services | Monoterpenes, sesquiterpenes and diterpenes as cancer therapy |
| US5876728A (en) * | 1995-02-15 | 1999-03-02 | Howard David Kass | Natural composition extracted from plants used in the treatment of cancer |
| AUPO316796A0 (en) * | 1996-10-23 | 1996-11-14 | Hood, John James David | Essential oil |
| US6464839B1 (en) | 1997-04-14 | 2002-10-15 | Yuan Da International Group Limited | Beta-elemene, method to prepare the same and uses thereof |
| US6265639B1 (en) * | 1998-01-22 | 2001-07-24 | Washington State University Foundation | Gymnosperm nucleic acid molecules encoding sesquiterpene synthases and methods of use |
| FR2808196A1 (fr) | 2000-04-27 | 2001-11-02 | Andre Rougereau | Nouveaux medicaments a base de melanges de sesquiterpenes |
| FR2811899B1 (fr) * | 2000-07-20 | 2003-02-07 | Anne Marie Pierrette Giraud | Association d'huiles essentielles et applications therapeutiques |
| US6486706B2 (en) | 2000-12-06 | 2002-11-26 | Intel Corporation | Domino logic with low-threshold NMOS pull-up |
| EP1351678A2 (en) * | 2001-01-02 | 2003-10-15 | Elizabeth Shanahan-Prendergast | Treatment for inhibiting neoplastic lesions using incensole and/or furanogermacrens |
| WO2002080951A1 (en) * | 2001-04-06 | 2002-10-17 | Synergistix Biotech, Inc. | Herbal extracts for the treatment of cancer |
| GB0210152D0 (en) * | 2002-05-02 | 2002-06-12 | Compton Developments Ltd | Use of plant materials |
| EP1587482A4 (en) * | 2003-01-31 | 2010-08-25 | Technion Res & Dev Foundation | INFLAMMATORY COMPOSITIONS AND ITS USES |
| US20050074509A1 (en) * | 2003-10-02 | 2005-04-07 | Data Medica Padova S.P.A. | Cancer treatment using natural plant products or essential oils extracted from some pistacia species or components |
-
2003
- 2003-11-13 GB GBGB0326518.8A patent/GB0326518D0/en not_active Ceased
-
2004
- 2004-11-12 CN CN2004800336500A patent/CN1882319B/zh not_active Expired - Fee Related
- 2004-11-12 JP JP2006538951A patent/JP2007511492A/ja not_active Withdrawn
- 2004-11-12 KR KR1020067011566A patent/KR20060121177A/ko not_active Ceased
- 2004-11-12 AU AU2004290946A patent/AU2004290946B2/en not_active Ceased
- 2004-11-12 DK DK04798492T patent/DK1682107T3/da active
- 2004-11-12 WO PCT/GB2004/004769 patent/WO2005049001A1/en not_active Ceased
- 2004-11-12 EP EP04798492A patent/EP1682107B1/en not_active Expired - Lifetime
- 2004-11-12 CA CA002545717A patent/CA2545717A1/en not_active Abandoned
- 2004-11-12 DE DE602004022578T patent/DE602004022578D1/de not_active Expired - Lifetime
- 2004-11-12 AT AT04798492T patent/ATE439126T1/de not_active IP Right Cessation
- 2004-11-12 CN CN201010205334A patent/CN101862365A/zh active Pending
- 2004-11-12 US US10/579,135 patent/US20070259056A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004022578D1 (de) | 2009-09-24 |
| EP1682107B1 (en) | 2009-08-12 |
| DK1682107T3 (da) | 2009-12-14 |
| AU2004290946B2 (en) | 2010-04-22 |
| KR20060121177A (ko) | 2006-11-28 |
| WO2005049001A1 (en) | 2005-06-02 |
| CN1882319A (zh) | 2006-12-20 |
| US20070259056A1 (en) | 2007-11-08 |
| CN101862365A (zh) | 2010-10-20 |
| CN1882319B (zh) | 2010-08-25 |
| JP2007511492A (ja) | 2007-05-10 |
| ATE439126T1 (de) | 2009-08-15 |
| AU2004290946A1 (en) | 2005-06-02 |
| GB0326518D0 (en) | 2003-12-17 |
| EP1682107A1 (en) | 2006-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |