CA2539572A1

CA2539572A1 - 1-(quinoline amino) and 1-(isoquinoline amino)-substituted pentan-2-ols, method for their production and their use as anti-inflammatories

Info

Publication number: CA2539572A1
Application number: CA002539572A
Authority: CA
Inventors: Stefan Jaroch; Stefan Baeurle; Markus Berger; Konrad Krolikiewicz; Duy Nguyen; Hartmut Rehwinkel; Norbert Schmees; Werner Skuballa; Heike Schaecke
Original assignee: Individual
Current assignee: Bayer Pharma AG
Priority date: 2003-10-06
Filing date: 2004-09-24
Publication date: 2005-04-21
Also published as: KR20060121894A; MXPA06003895A; BRPI0415084A; AU2004279544A1; JP2007507450A; ZA200603601B; WO2005035502A1; IL174433A0; CN1863775A; EP1673344A1; DE10346940B3; NO20062022L

Abstract

The invention relates to substituted pentanols, to a method for their production and to their use as anti-inflammatories.

Description

Substituted Pentanols, A Process for their Production and their Use as Anti-inflammatory Agents The invention relates to quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents.
From the prior art of DE 100 38 639 and W002/10143, anti-inflammatory agents of general formula R' RZ HO R3 A B A~ ~I~
are known, whereby the Ar radical comprises phthalides, thiophthalides, benzoxazinones or phthalazinones. In the experiment, these compounds show dissociations of action between anti-inflammatory and undesirable metabolic actions and are superior to the previously described nonsteroidal glucocorticoids or exhibit at least just as good an action.
The selectivity of the compounds of the prior art compared to the other steroid receptors still requires improvement, however.
It was therefore the object of this invention to make available compounds whose selectivity is improved compared to the other steroid receptors.
This object is achieved by the compounds according to the claims.

This invention therefore relates to compounds of general formula I
R~ R2 Rs A'\~B~ ~Q
HO (I) in which A stands for an aryl, a benzyl or a phenethyl group, whereby the aryl, benzyl or phenethyl group optionally can be substituted by one or more radicals from the group C~-CS-alkyl, C~-CS-alkoxy, C,-CS-alkylthio, C~-CS-perfluoroalkyl, halogen, hydroxy, cyano, nitro, -O-(CHz)"-O-, -O-(CHz)"-CHz-, -O-CH=CH-, or -(CHz)"+z-, whereby n = 1 or 2, and the terminal oxygen atoms and/or carbon atoms are linked to directly adjacent ring-carbon atoms, or NR4R5, whereby R4 and R5, independently of one another, can be hydrogen, C~-CS-alkyl or (CO)-C,-CS-alkyl, R' and Rz, independently of one another, mean a hydrogen atom, a methyl or ethyl group, or together with the carbon atom mean the chain of a C3-C6-eycloalkyl ring, R3 means an optionally substituted group that is selected from CQ-Cg-alkyl, Cz-C6-alkenyl, Cz-C6-alkinyl, C3-C8-cycloalkyl, C3-C~-heterocyclyl, aryl, heteroaryl, (C,-Cg-alkyl)C3-C8-cycloalkyl, (C~-Cg-alkyl)aryl, or (C,-Cg-alkyl)heteroaryl, B means a methylene group or a carbonyl group that is optionally substituted by a methyl or ethyl group, and Q means a quinolinyl or isoquinolinyl group that is linked via any position and that optionally can be substituted by one or more radicals from the group C~-CS-alkyl, C~-CS-alkoxy, C~-CS-alkylthio, C~-CS-perfluoroalkyl, halogen, hydroxy, cyano, vitro, or NR4R5, whereby R4 and R5, independently of one another, can be hydrogen, C~-CS-alkyl or (CO)-C~-CS-alkyl, as well as their racemates or separately present stereoisomers, and optionally their physiologically compatible salts.
An aryl group comprises phenyl and naphthyl. Phenyl is preferred.
The substituted aryl, benzyl or phenethyl groups carry 1-3 substituents, preferably 2 substituents, on the ring.
The following substitution patterns on ring A are a special subject of the invention: 2,5-disubstituted phenyl derivatives and 2,4-disubstituted phenyl derivatives.
The C~-CS-alkyl groups in A, R4, and RS can be straight-chain or branched and stand for a methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, tert.-butyl- or n-pentyl, 2,2-dimethylpropyl, 2-methylbutyl or 3-methylbutyl group. A methyl or ethyl group is preferred.
The Ca-C8-alkyl group R3 can be straight-chain or branched and can mean, e.g., butyl, isobutyl, tent-butyl, pentyl or isopentyl.
The CZ-C6-alkenyl group is straight-chain or branched; for example, vinyl, propenyl, isopropenyl, butenyl, or isobutenyl is suitable.
The CZ-C6-alkinyl group is straight-chain or branched; for example, ethinyl, propinyl, or butinyl is suitable.
For a cycloalkyl group, for example, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl are considered.

The heterocyclyl group is not aromatic and can be, for example, pyrrolidine, imidazolidine, pyrazolidine, or piperidine.
The C~-C8-alkyl(C3-Cg)cycloalkyl group can be, for example, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, or cycloheptylmethyl. The linkage with the chain is carned out via the alkyl group.
For an aryl group, phenyl and naphthyl are considered, and for (C~-C8)alkylaryl, benzyl and homobenzyl are considered.
Heteroaryl comprises furanyl, thienyl, thiazolyl, oxazolyl, imidazolyl, triazolyl, pyridyl and pyrimidyl;
(C,-C8-Alkyl)heteroaryl comprises all combinations of the above-indicated definition of alkyl with monocyclic aromatic heterocyclic compounds. The linkage with the chain is carried out via the alkyl group, which in turn is linked to any possible chemical position of the heterocyclic compound.
The substituents of the groups in R3 can be C~-C6-alkyl, CZ-C6-alkenyl, CZ-C6-alkinyl, C,-C6-alkoxy, halogen, hydroxy, and NR4R5.
Alkyl radicals R' and RZ together with the carbon atom of the chain can form a to 6-membered ring.
The C~-CS-alkoxy groups in A and Q can be straight-chain or branched and stand for a methoxy, ethoxy, n-propoxy-, iso-propoxy-, n-butoxy, iso-butoxy, tert.-butoxy or n-pentoxy, 2,2-dimethylpropoxy, 2-methylbutoxy or 3-methylbutoxy group. A
methoxy or ethoxy group is preferred.
The C~-CS-alkylthio groups in A and Q can be straight-chain or branched and stand for a methylthio, ethylthio, n-propylthio, iso-propylthio, n-butylthio, iso-butylthio, tert.-butylthio or n-pentylthio, 2,2-dimethylpropylthio, 2-methylbutylthio or methylbutylthio group. A methylthio or ethylthio group is preferred.

The designation halogen atom or halogen means a fluorine, chlorine, bromine or iodine atom. A fluorine, chlorine or bromine atom is preferred.
The NRQRS group can mean, for example, NHz, N(H)CH3, N(CH3)z, N(H)(CO)CH3, N(CH3)(CO)CH3, N[(CO)CH3Jz, N(H)COzCH3, N(CH3)COZCH3, or N(COzCH3)z.
As alkyl radicals R4 and R5, C~-C3-alkyl is preferred.
As acyl radicals R4 and R5, (CO)-C,-C3-alkyl is preferred.
For radical B, the unsubstituted methylene group and the carbonyl group are preferred.
Radical Q can be linked via any ring-carbon atom to the (NH)-group of the chain. 4-, 5- and 8-positions are preferred for the quinoline ring, and l-position is preferred for the isoquinoline ring.
The compounds of general formula I according to the invention can be present as different stereoisomers because of the presence of asymmetry centers. Both the racemates and the separately present stereoisomers are part of the subject of this invention.
A special subject of this invention are the separately present stereoisomers, i.e., (+)-enantiomers and (-)-enantiomers.
Another subject of the invention relates to compounds in which A stands for an aryl, a benzyl or a phenethyl group, whereby the aryl, benzyl or phenethyl group optionally can be substituted by one or more radicals from the group C~-CS-alkyl, C,-CS-alkoxy, C~-CS-alkylthio, C~-CS-perfluoroalkyl, halogen, hydroxy, cyano, vitro or NR4R5, whereby RQ and R5, independently of one another, can be hydrogen, C~-CS-alkyl or (CO)-C ~-CS-alkyl.

Another subject of the invention relates to compounds of general formula I, in which A stands for -0-(CHz)"-O, -O-(CHz)"-CHz-, -O-CH=CH-, or -(CHz)n+z-~
whereby n = 1 or 2, and the terminal oxygen atoms and/or carbon atoms are linked to directly adjacent ring-carbon atoms.
Compounds according to claim l, in which R3 means an optionally substituted group that is selected from C4-C8-alkyl, C3-C8-cycloalkyl, C3-C~-heterocyclyl, aryl, heteroaryl, (C~-C8-alkyl)C3-Cg-cycloalkyl, (C,-Cg-alkyl)aryl, or (C,-C8-alkyl)heteroaryl, are another subject of the invention.
Compounds according to claim 1, in which R3 means an optionally substituted group that is selected from C3-C6-cycloalkyl, C3-C~-heterocyclyl, phenyl, heteroaryl, (C~-C3-alkyl)C3-C6-cycloalkyl, (C,-C3-alkyl)phenyl, or (C~-C3-alkyl)heteroaryl, are another subject of the invention.
Compounds of general formula I, in which A means an unsubstituted phenyl group, R' and Rz mean methyl, R3 means a cyclopentyl group, a methylcyclohexyl group or a phenyl group, B means a methylene group and Q means a quinoline or isoquinoline group, are another subject of the invention.
Compounds of general formula I, in which A means an unsubstituted phenyl group, R' and Rz mean a methyl group, R3 means a cyclopentyl group, a methylcyclohexyl group or a phenyl group, B means a methylene group and Q
means a quinoline group, are another subject of the invention.
In addition, subjects of the invention are the use of the compounds according to claim 1 for the production of pharmaceutical agents, the use of the compounds according to claim 1 for the production of a pharmaceutical agent for treating inflammatory diseases and pharmaceutical preparations that contain at least one compound according to claim 1 or their mixtures as well as pharmaceutically compatible vehicles.

Compounds of general formula I in which R3 means C3-C8-cycloalkyl, (C~-CBalkyl)C3-C8-eycloalkyl, benzyl or phenyl are a preferred subject of the invention.
Compounds of general formula I in which R3 means C3-C8-cycloalkyl, (C~-CBalkyl)C3-C8-cycloalkyl or phenyl are an especially preferred subject of the invention, and compounds of general formula I in which R3 means cyclopentyl, methylcyclohexyl or phenyl, as described in the examples, are quite especially preferred.
The process for the production of the compounds of W098/54159 (51488), WO00/32584 (51642), and W002/10143 (S 1877) can also be used for the production of the compounds according to the invention. For the linkage of the quinoline or isoquinoline groups that are characteristic of the compounds according to the invention, the following process steps can be performed:

AI) forB=CO
R' RZ O Q-NH R' RZ O R' R2 R3 A' v 'COZH - Z A NH-Q ~ A NH-O
(II) O O
(III) (I) An a-keto acid of general formula (II), in which A, R' and RZ have the meanings that are indicated for formula (I), is converted with an aminoquinoline, an aminoisoquinoline or a (partially-) hydrogenated quinoline or isoquinoline derivative (Q-NHz ) into a-ketoamide (III), whereby A, R' and RZ have the above-indicated meanings, in the way that is known to one skilled in the art. For example, a-ketoamide (III) is obtained with use of dehydrating coupling reagents, as they are known from peptide chemistry, e.g., dicyclohexylcarbodiimide, or by upstream conversion of the acid into an acid chloride, e.g., with thionyl chloride or POCI3 and subsequent reaction with Q-NH2.
R~ R2 O
A\~~ NH-Q
'(III) ~O
Compound (III) is reacted either with an alkyl metal compound, for example a Grignard reagent, or a lithium alkyl, or by reaction with compound (IV), (R6)3s1_R3 (IV) whereby R3 has the above-indicated meaning, and R6 refers to a C~-CS-alkyl group, in the presence of a catalyst, e.g., fluoride salts or bases, such as, for example, alkali carbonates (J. Am. Chem. ,Soc. 1989, 111, 393), to form title compound (I).
forB=CO

R' Rz O 1, verestern R' Rz R Q-NHz R R
NH-Q
A~COZH ' A~C02H A
2. (R6)3SiR3 OH O
(II) (VI) (I) [Key: verestern = esterificationJ
As an alternative, a-keto acids (II) can also be esterified to compounds (V), R' Rz O
A\ v _COZR' (V) in which A, R' and RZ are defined as described above, and R' is C~-Ca-alkyl, according to commonly used methods, e.g., with thionyl chloride in methanol or ethanol or with methyl iodide and alkali carbonate, and can be converted from (III) to (I) in compound (VI) analogously to reaction sequence Al).
R' Rz R3 A\ Ho 'C02R' (VI) The ester is saponified under standard conditions, for example aqueous alkali hydroxide solution, to acid (VI; R' = H). The latter is reacted for coupling with an aminoquinoline or aminoisoquinoline or a (partially-) hydrogenated quinoline or isoquinoline derivative (Q-NHz) with use of a conventional activating reagent, e.g., thionyl chloride, optionally in the presence of a catalyst such as dimethyl aminopyridine, to form title compound (I).
B) R' Rz Ra R' R2 Rs A\~~O a) A\u~NH-Q
'O~rg Title compound (I) can also be synthesized by reductive amination of a compound of formula (XII) with Q-NH2, whereby, e.g., sodium cyanoborohydride, or sodium triacetoxy borohydride is considered as a reducing agent.
R' R2 Ra A O
R
(X11) Rg means methyl or ethyl according to the substituents that are defined for the methylene group in B.

In the case that the compounds of general formula I are present as salts, this can be, for example, in the form of hydrochloride, sulfate, nitrate, phosphate, pivalate, maleate, fumarate, tartrate, benzoate, mesylate, citrate or succinate.
If the compounds according to the invention are present as racemic mixtures, they can be separated into pure, optically active forms according to the methods of racemate separation that are familiar to one skilled in the art. For example, the racemic mixtures can be separated by chromatography on an even optically active carrier material (CHIRALPAK AD~) into the pure isomers. It is also possible to esterify the free hydroxy group in a racemic compound of general formula I with an optically active acid and to separate the diastereoisomeric esters that are obtained by fractionated crystallization or by chromatography, and to saponify the separated esters in each case to the optically pure isomers. As an optically active acid, for example, mandelic acid, camphorsulfonic acid or tartaric acid can be used.
Moreover, the methods for the production of the compounds according to the invention that are used in the experimental part are also part of the disclosure for the producibility of the claimed compounds.
The binding of the substances to the glucocorticoid receptor (GR) and other steroid hormone receptors (mineral corticoid receptor (MR), progesterone receptor (PR) and androgen receptor (AR)) is examined with the aid of recombinantly produced receptors. Cytosol preparations of Sf9 cells, which had been infected with recombinant baculoviruses, which code for the GR, are used for the binding studies. In comparison to reference substance [3HJ-dexamethasone, the substances show a high to very high affinity to GR.
Moreover, the quinolines and isoquinolines of formula (I) that are described here show a high selectivity for the glucocorticoid receptor.

As an essential, molecular mechanism for the anti-inflammatory action of glucocorticoids, the GR-mediated inhibition of the transcription of cytokines, adhesion molecules, enzymes and other pro-inflammatory factors is considered. This inhibition is produced by an interaction of the GR with other transcription factors, e.g., AP-1 and NF-kappa-B (for a survey, see Cato, A. C. B. and Wade, E., BioEssays 18, 371-378, 1996).
The compounds of general formula I according to the invention inhibit the secretion of cytokine IL-8 into the human monocyte cell line THP-1 that is triggered by lipopolysaccharide (LPS). The concentration of the cytokines was determined in the supernatant by means of commercially available ELISA kits.
The anti-inflammatory action of the compounds of general formula I was tested in the animal experiment by tests in the croton oil-induced inflammation in rats and mice (J. Exp. Med. (1995), 182, 99-108). To this end, croton oil in ethanolic solution was applied topically to the animals' ears. The test substances were also applied topically or systemically at the same time or two hours before the croton oil. After 16-24 hours, the ear weight was measured as a yardstick for inflammatory edema, the peroxidase activity as a yardstick for the invasions of granulocytes, and the elastase activity as a yardstick for the invasion of neutrophilic granulocytes. In this test, the compounds of general formula I inhibit the three above-mentioned inflammation parameters both after topical administration and after systemic administration.
One of the most frequent undesirable actions of a glucocorticoid therapy is the so-called "steroid diabetes" [cf., Hatz, H. J., Glucocorticoide:
Immunologische Grundlagen, Pharmakologie and Therapierichtlinien, [Glucocorticoids:
Immunological Bases, Pharmacology and Therapy Guidelines], Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 1998). The reason for this is the stimulation of gluconeogenesis in the liver by induction of the enzymes responsible in this respect and by free amino acids, which are produced from the degradation of proteins (catabolic action of glucocorticoids). A key enzyme of the catabolic metabolism in the liver is tyrosinamino transferase (TAT). The activity of this enzyme can be determined from liver homogenates by photometry and represents a good measurement of the undesirable metabolic actions of glucocorticoids. To measure the TAT induction, the animals are sacrificed 8 hours after the test substances are administered, the livers are removed, and the TAT activity is measured in the homogenate. In this test, at doses in which they have an anti-inflammatory action, the compounds of general formula I induce little or no tyrosinamino transferase.
Because of their anti-inflammatory and, in addition, anti-allergic, immunosuppressive and antiproliferative action, the compounds of general formula I
according to the invention can be used as medications for treatment or prophylaxis of the following pathologic conditions in mammals and humans: In this case, the term "DISEASE" stands for the following indications:
(i) Lung diseases that are accompanied by inflammatory, allergic and/or proliferative processes:
- Chronic, obstructive lung diseases of any origin, primarily bronchial asthma - Bronchitis of different origins - All forms of restrictive lung diseases, primarily allergic alveolitis, All forms of pulmonary edema, primarily toxic pulmonary edema - Sarcoidoses and granulomatoses, especially Boeck's disease (ii) Rheumatic diseases/autoimmune diseases/joint diseases that are accompanied by inflammatory, allergic andlor proliferative processes:

- All forms of rheumatic diseases, especially rheumatoid arthritis, acute rheumatic fever, polymyalgia rheumatica - Reactive arthritis - Inflammatory soft-tissue diseases of other origins - Arthritic symptoms in the case of degenerative joint diseases (arthroses) - Traumatic arthritides - Collagenoses of any origin, e.g., systemic lupus erythematodes, sclervdermia, polymyositis, dermatomyositis, Sjogren's syndrome, Still's syndrome, Felty's syndrome (iii) Allergies that are accompanied by inflammatory and/or proliferative processes:
- All forms of allergic reactions, e.g., Quincke's edema, hay fever, insect bites, allergic reactions to pharmaceutical agents, blood derivatives, contrast media, etc., anaphylactic shock, urticaria, contact dermatitis (iv) Vascular inflammations (vasculitides) - Panarteritis nodosa, temporal arteritis, erythema nodosum (v) Dermatological diseases that are accompanied by inflammatory, allergic andlor proliferative processes:
- Atopic dermatitis (primarily in children) - Psoriasis - Pityriasis rubra pilaris - Erythematous diseases, triggered by different noxae, e.g., radiation, chemicals, burns, etc.
- Bullous dermatoses - Diseases of the lichenoid group, - Pruritis (e.g., of allergic origin) - Seborrhea) eczema - Rosacea - Pemphigus vulgaris - Erythema exudativum multiforme - Balanitis - Vulvitis - Hair loss such as alopecia areata - Cutaneous T-cell lymphoma (vi) Kidney diseases that are accompanied by inflammatory, allergic and/or proliferative processes:
- Nephrotic syndrome - All nephritides (vii) Liver diseases that are accompanied by inflammatory, allergic and/or proliferative processes:
- Acute liver cell decomposition - Acute hepatitis of different origins, e.g., viral, toxic, pharmaceutical agent-induced - Chronic aggressive hepatitis and/or chronic intermittent hepatitis (viii) Gastrointestinal diseases that are accompanied by inflammatory, allergic andlor proliferative processes:
- Regional enteritis (Crohn's disease) - Colitis ulcerosa - Gastritis - Reflux esophagitis - Ulcerative colitis of other origins, e.g., native spree (ix) Proctologic diseases that are accompanied by inflammatory, allergic and/or proliferative processes:
- Anal eczema - Fissures - Hemorrhoids - Idiopathic proctitis (x) Eye diseases that are accompanied by inflammatory, allergic and/or proliferative processes:
- Allergic keratitis, uveitis, iritis - Conjunctivitis - Blepharitis - Optic neuritis - Chorioiditis - Sympathetic ophthalmia (xi) Diseases of the ear-nose-throat area that are accompanied by inflammatory, allergic and/or proliferative processes:
- Allergic rhinitis, hay fever Otitis externa, e.g., caused by contact dermatitis, infection, etc.
- Otitis media (xii) Neurological diseases that are accompanied by inflammatory, allergic and/or proliferative processes:
- Cerebral edema, primarily tumor-induced cerebral edema - Multiple sclerosis - Acute encephalomyelitis - Meningitis - Various forms of convulsions, e.g., infantile nodding spasms (xiii) Blood diseases that are accompanied by inflammatory, allergic and/or proliferative processes:
- Acquired hemolytic anemia - Idiopathic thrombocytopenia (xiv) Tumor diseases that are accompanied by inflammatory, allergic and/or proliferative processes:
- Acute lymphatic leukemia - Malignant lymphoma Lymphogranulomatoses - Lymphosarcoma - Extensive metastases, mainly in breast, bronchial and prostate cancers (xv) Endocrine diseases that are accompanied by inflammatory, allergic and/or proliferative processes:
- Endocrine orbitopathy Thyreotoxic crisis - De Quervain's thyroiditis - Hashimoto's thyroiditis - Basedow's disease (xvi) Organ and tissue transplants, graft-versus-host disease (xvii) Severe shock conditions, e.g., anaphylactic shock, systemic inflammatory response syndrome (SIRS) (xviii) Substitution therapy in:
- Innate primary suprarenal insufficiency, e.g., congenital adrenogenital syndrome - Acquired primary suprarenal insufficiency, e.g., Addison's disease, autoimmune adrenalitis, meta-infective tumors, metastases, etc.
- Innate secondary suprarenal insufficiency, e.g., congenital hypopituitarism - Acquired secondary suprarenal insufficiency, e.g., meta-infective tumors, etc.
(xix) Vomiting that is accompanied by inflammatory, allergic and/or proliferative processes:
- e.g., in combination with a 5-HT3 antagonist in cytostatic-agent-induced vomiting (xx) Pains of inflammatory origins, e.g., lumbago.
Moreover, the compounds of general formula I according to the invention can be used for treatment and prophylaxis of additional pathologic conditions that are not mentioned above, for which synthetic glucocorticoids are now used (see in this respect Hatz, H. J., Glucocorticoide: Immunologische Grundlagen, Pharmakologie and Therapierichtlinien, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 1998).
All previously mentioned indications (i) to (xx) are described in more detail in Hatz, H. J., Glucocorticoide: Immunologische Grundlagen, Pharmakologie and Therapierichtlinien, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 1998.
For the therapeutic actions in the above-mentioned pathologic conditions, the suitable dose varies and depends on, for example, the active strength of the compound of general formula I, the host, the type of administration, and the type and severity of the conditions that are to be treated, as well as the use as a prophylactic agent or therapeutic agent.

In addition, the invention provides:
(i) The use of one of the compounds of general formula I according to the invention or mixture thereof for the production

Claims

1. Compounds of general formula I

in which A stands for an aryl, a benzyl or a phenethyl group, whereby the aryl, benzyl or phenethyl group optionally can be substituted by one or more radicals from the group C1-C5-alkyl, C1-C5-alkoxy, C1-C5-alkylthio, C1-C5-perfluoroalkyl, halogen, hydroxy, cyano, nitro, -O-(CH2)n-O-, -O-(CH2)n-CH2-, -O-CH=CH-, or -(CH2)n+2-, whereby n = 1 or 2, and the terminal oxygen atoms and/or carbon atoms are linked to directly adjacent ring-carbon atoms, or NR4R5, whereby R4 and R5, independently of one another, can be hydrogen, C1-C5-alkyl or (CO)-C1-C5-alkyl, R1 and R2, independently of one another, mean a hydrogen atom, a methyl or ethyl group, or together with the carbon atom mean the chain of a C3-C6-cycloalkyl ring, R3 means an optionally substituted group that is selected from C4-C8-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C8-cycloalkyl, C3-C7-heterocyclyl, aryl, heteroaryl, (C1-C8-alkyl)C3-C8-cycloalkyl, (C1-C8-alkyl)aryl, or (C1-C8-alkyl)heteroaryl, B means a methylene group or a carbonyl group that is optionally substituted by a methyl or ethyl group, and Q means a quinolinyl or isoquinolinyl group that is linked via any position and that optionally can be substituted by one or more radicals from the group C1-C5-alkyl, C1-C5-alkoxy, C1-C5-alkylthio, C1-C5-perfluoroalkyl, halogen, hydroxy, cyano, nitro, or NR4R5, whereby R4 and R5, independently of one another, can be hydrogen, C1-C5-alkyl or (CO)-C1-C5-alkyl, as well as their racemates or separately present stereoisomers, and optionally their physiologically compatible salts.

2. Compounds of general formula I, according to claim 1, in which A stands for an aryl group.

3. Compounds according to claim 1 or 2, in which A means -O-(CH2)n-O-, -O-(CH2)n-CH2-, -O-CH=CH-, or -(CH2)n+2-, whereby n = 1 or 2, and the terminal oxygen atoms and/or carbon atoms are linked to directly adjacent ring-carbon atoms.

4. Compounds according to claim 1 or 2, in which R3 means an optionally substituted group that is selected from C4-C8-alkyl, C3-C8-cycloalkyl, C3-C7-heterocyclyl, aryl, heteroaryl, (C1-C8-alkyl)C3-C8-cycloalkyl, (C1-C8-alkyl)aryl, or (C1-C8-alkyl)heteroaryl.

5. Compounds according to claim 1 or 2, in which R3 means an optionally substituted group that is selected from C3-C6-cycloalkyl, C3-C7-heterocyclyl, phenyl, heteroaryl, (C1-C3-alkyl)C3-C6-cycloalkyl, (C1-C3-alkyl)phenyl or (C1-C3-alkyl)heteroaryl.

6. Use of the compounds according to claim 1 for the production of pharmaceutical agents.

7. Use of the compounds according to claim 1 for the production of a pharmaceutical agent for treating inflammatory diseases.

8. Pharmaceutical preparations that contain at least one compound according to claim 1 or mixtures thereof as well as pharmaceutically compatible vehicles.