CA2536679A1 - Powdery preparations containing 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxi)-1,3,5-triazine - Google Patents
Powdery preparations containing 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxi)-1,3,5-triazine Download PDFInfo
- Publication number
- CA2536679A1 CA2536679A1 CA002536679A CA2536679A CA2536679A1 CA 2536679 A1 CA2536679 A1 CA 2536679A1 CA 002536679 A CA002536679 A CA 002536679A CA 2536679 A CA2536679 A CA 2536679A CA 2536679 A1 CA2536679 A1 CA 2536679A1
- Authority
- CA
- Canada
- Prior art keywords
- triazine
- water
- acid
- disperse
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 229960002718 selenomethionine Drugs 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000002884 skin cream Substances 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 235000010268 sodium methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 1
- PESXGULMKCKJCC-UHFFFAOYSA-M sodium;4-methoxycarbonylphenolate Chemical compound [Na+].COC(=O)C1=CC=C([O-])C=C1 PESXGULMKCKJCC-UHFFFAOYSA-M 0.000 description 1
- IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical compound [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- ARCJQKUWGAZPFX-UHFFFAOYSA-N stilbene oxide Chemical compound O1C(C=2C=CC=CC=2)C1C1=CC=CC=C1 ARCJQKUWGAZPFX-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 150000001629 stilbenes Chemical class 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 125000005555 sulfoximide group Chemical group 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229960000368 sulisobenzone Drugs 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- LVEOKSIILWWVEO-UHFFFAOYSA-N tetradecyl 3-(3-oxo-3-tetradecoxypropyl)sulfanylpropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCSCCC(=O)OCCCCCCCCCCCCCC LVEOKSIILWWVEO-UHFFFAOYSA-N 0.000 description 1
- NZNAAUDJKMURFU-UHFFFAOYSA-N tetrakis(2,2,6,6-tetramethylpiperidin-4-yl) butane-1,2,3,4-tetracarboxylate Chemical compound C1C(C)(C)NC(C)(C)CC1OC(=O)CC(C(=O)OC1CC(C)(C)NC(C)(C)C1)C(C(=O)OC1CC(C)(C)NC(C)(C)C1)CC(=O)OC1CC(C)(C)NC(C)(C)C1 NZNAAUDJKMURFU-UHFFFAOYSA-N 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 235000019303 thiodipropionic acid Nutrition 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229930003802 tocotrienol Natural products 0.000 description 1
- 239000011731 tocotrienol Substances 0.000 description 1
- 235000019148 tocotrienols Nutrition 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 150000003918 triazines Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- AZSKHRTUXHLAHS-UHFFFAOYSA-N tris(2,4-di-tert-butylphenyl) phosphate Chemical compound CC(C)(C)C1=CC(C(C)(C)C)=CC=C1OP(=O)(OC=1C(=CC(=CC=1)C(C)(C)C)C(C)(C)C)OC1=CC=C(C(C)(C)C)C=C1C(C)(C)C AZSKHRTUXHLAHS-UHFFFAOYSA-N 0.000 description 1
- OOZBTDPWFHJVEK-UHFFFAOYSA-N tris(2-nonylphenyl) phosphate Chemical compound CCCCCCCCCC1=CC=CC=C1OP(=O)(OC=1C(=CC=CC=1)CCCCCCCCC)OC1=CC=CC=C1CCCCCCCCC OOZBTDPWFHJVEK-UHFFFAOYSA-N 0.000 description 1
- KNZMCZBALCXBTN-UHFFFAOYSA-N tris(2-tert-butyl-4-methylphenyl) phosphate Chemical compound CC(C)(C)C1=CC(C)=CC=C1OP(=O)(OC=1C(=CC(C)=CC=1)C(C)(C)C)OC1=CC=C(C)C=C1C(C)(C)C KNZMCZBALCXBTN-UHFFFAOYSA-N 0.000 description 1
- UEVAMYPIMMOEFW-UHFFFAOYSA-N trolamine salicylate Chemical compound OCCN(CCO)CCO.OC(=O)C1=CC=CC=C1O UEVAMYPIMMOEFW-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940040064 ubiquinol Drugs 0.000 description 1
- QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a method for the production of powdery preparations containing 2.4.6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxi)-1.3.5-triazine of formula (I), by a) dispersing the triazine (I) in an aqueous molecular dispersed or colloid dispersion solution of a protective colloid and b) transforming the formed dispersion into a dried powder by separating water and, optionally, additionally used solvent and by drying. The invention is characterised in that modified starch is used as a protective colloid in step (a).
Description
POWDERY PREPARATIONS CONTAINING 2,4,6-TRIANILINO-P-(CARBO-2'-ETHYLHEXYL-1'-OXI)-1,3,5-TRIAZIN E
The invention relates to powdered preparations comprising 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)-1,3,5-triazine, to their preparation and to the use thereof as photostable photoprotective agents.
The quality and life span of many organic materials, for example plastics and coating materials, but also pharmaceutical and cosmetic preparations, can be adversely affected by the action of light, in particular by UV rays. These losses in quality frequently become evident in the case of plastics and coating materials from yellowing, discoloration, cracking or embrittlement of the material. In the case of pharmaceutical and cosmetic preparations, the effect of UV rays can lead to the degradation of the active ingredients present in the formulations.
The harmful effect of the ultraviolet part of solar radiation on the skin or hair, which in the widest sense are also an organic material, is likewise a problem which is increasing in importance. While rays having a wavelength of less than 290 nm (the UVC
region) are absorbed by the ozone layer in the earth's atmosphere, rays in the range between 290 nm and 320 nm, the UVB region, cause an erythema, simple sunburn or even burns of varying severity on the skin.
A maximum for the erythema activity of sunlight is given as the relatively narrow range around 308 nm.
Numerous compounds are known for protecting against UVB radiation; these are, inter alia, triazine derivatives; derivatives of 3-benzylidenecamphor, of 4-aminobenzoic acid, of cinnamic acid, of salicylic acid, of benzophenone and of 2-phenylbenzimidazole.
It is also important to have available filter substances for the range between about 320 nm and about 400 nm, the UVA region, since its rays can cause reactions in cases of photosensitive skin. It has been proven that UVA radiation leads to damage of the elastic and collagenous fibers of the connective tissue, leading to premature aging of the skin, and that it is to be regarded as a cause of numerous phototoxic and photoallergic reactions. The harmful effect of UVB radiation can be intensified by UVA
radiation.
To protact against UVA rays, derivatives of dibenzoylmethane are used, the photostability of which, however, is inadequate (Int. J. Cosm. Science 10, 53 (1988)).
However, UV radiation can also lead to photochemical reactions, in which case the photochemical reaction products then intervene in the skin's metabolism.
rr 54t38Z
The invention relates to powdered preparations comprising 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)-1,3,5-triazine, to their preparation and to the use thereof as photostable photoprotective agents.
The quality and life span of many organic materials, for example plastics and coating materials, but also pharmaceutical and cosmetic preparations, can be adversely affected by the action of light, in particular by UV rays. These losses in quality frequently become evident in the case of plastics and coating materials from yellowing, discoloration, cracking or embrittlement of the material. In the case of pharmaceutical and cosmetic preparations, the effect of UV rays can lead to the degradation of the active ingredients present in the formulations.
The harmful effect of the ultraviolet part of solar radiation on the skin or hair, which in the widest sense are also an organic material, is likewise a problem which is increasing in importance. While rays having a wavelength of less than 290 nm (the UVC
region) are absorbed by the ozone layer in the earth's atmosphere, rays in the range between 290 nm and 320 nm, the UVB region, cause an erythema, simple sunburn or even burns of varying severity on the skin.
A maximum for the erythema activity of sunlight is given as the relatively narrow range around 308 nm.
Numerous compounds are known for protecting against UVB radiation; these are, inter alia, triazine derivatives; derivatives of 3-benzylidenecamphor, of 4-aminobenzoic acid, of cinnamic acid, of salicylic acid, of benzophenone and of 2-phenylbenzimidazole.
It is also important to have available filter substances for the range between about 320 nm and about 400 nm, the UVA region, since its rays can cause reactions in cases of photosensitive skin. It has been proven that UVA radiation leads to damage of the elastic and collagenous fibers of the connective tissue, leading to premature aging of the skin, and that it is to be regarded as a cause of numerous phototoxic and photoallergic reactions. The harmful effect of UVB radiation can be intensified by UVA
radiation.
To protact against UVA rays, derivatives of dibenzoylmethane are used, the photostability of which, however, is inadequate (Int. J. Cosm. Science 10, 53 (1988)).
However, UV radiation can also lead to photochemical reactions, in which case the photochemical reaction products then intervene in the skin's metabolism.
rr 54t38Z
Such photochemical reaction products are mainly free-radical compounds, for example hydroxyl radicals. Undefined free-radical photo products formed in the skin itself can also trigger uncontrolled secondary reactions as a result of their high reactivity.
However, singlet oxygen, a non-radical excited state of the oxygen molecule, can also arise during UV irradiation, as can short-lived epoxides and many others.
Singlet oxygen, for example, differs from normal triplet oxygen (free-radical ground state) by virtue of its increased reactivity. However, activated, reactive (free-radical) triplet states of the oxygen molecule also exist.
Furthermore, UV radiation is a form of ionizing radiation. There is therefore the risk that ionic species will also form during UV exposure, which then for their part are able to intervene oxidatively in the biochemical processes.
One applications-relevant disadvantage of many UV filters is their poor solubility in water and/or in natural and synthetic oils, for example in silicone oils and in fatty acid triglycerides, as a result of which their use, for example in cosmetic formulations, is often restricted.
A further disadvantage associated with the application of some photoprotective agents is the appearance of skin irritations and allergies resulting from too high a skin permeability.
Numerous methods have already been published for improving the formulation properties of insoluble or only sparingly soluble UV absorbers.
For example, GB-A-2 303 549 describes a grinding process for the preparation of micronized insoluble organic UV absorbers in the presence of alkyl polyglycosides. The resulting micronizates can be incorporated into cosmetic photoprotective preparations.
GB-A-2 286 774 likewise describes a grinding process for the micronization of insoluble organic UV absorbers.
EP-A-1 127 567 describes aqueous dispersions of sparingly water-soluble or water-insoluble organic UV filter substances and dry powders produced therefrom, wherein they comprise at least one sparingly water-soluble or water-insoluble organic UV filter substance as colloidally disperse phase in amorphous of partially amorphous form. The use of the protective colloids specified in this specification - in particular gelatin or casein or caseinate - leads to powdered products whose solubility in cold water is unsatisfactory. In addition, gelatin and casein in cosmetic formulations can cause skin allergies.
It was then an object of the present invention to provide a method of producing triazine-containing photoprotective agent formulations which offer effective protection for organic material, in particular for the human skin and/or human hair, against UV rays, which are well tolerated by the skin and which can be incorporated easily both into lipophilic and also in particular into aqueous systems.
This object was achieved by a method of producing powdered preparations comprising 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)-1,3,5-triazine of the formula I
IzHs H9C4 HC- HzCOOC / ~ NH CzHs ~--N
CzHS N~ ~-NH~COOCHz -CH-C4H9 N
N
H9C4 HC- H2COOC~ H
by a) dispersing the triazine I in an aqueous molecularly disperse or colloidally disperse solution of a protective colloid and b) converting the dispersion obtained into a dry powder by removing the water and, if appropriate, additionally used solvents, and drying, wherein the protective colloid used in process step a) is modified starch.
2,4,6-Trianilino-p-(carbo-2'-ethylhexyl-1 '-oxy)-1,3,5-triazine of the formula I is marketed by BASF Aktiengesellschaft under the trade name Uvinul~ T150 as a UVB
filter. Uvinul~ T150 is notable, inter alia, for good UV absorption properties with an exceptionally high absorbance coefficient > 1500 at 314 nm.
For the purposes of the present invention, the term aqueous dispersions is understood as meaning both aqueous suspensions and emulsions. Preferred aqueous suspensions which may be mentioned are those in which the disperse phase comprises the triazine I as nanoparticulate particles.
For the purposes of the present invention, the term modified starch preferably comprises esters of starch with organic acids, e.g. with acetic acid and higher fatty acids (C6-Czs), and with succinic acid, adipic acid and citric acid. The starch can be obtained here, inter alia, from corn, potatoes or wheat. A particularly preferred modified starch is octenyl succinate starch, which is marketed under the trade name HiCap~ by National Starch or EmCap~ by Cerestar.
However, singlet oxygen, a non-radical excited state of the oxygen molecule, can also arise during UV irradiation, as can short-lived epoxides and many others.
Singlet oxygen, for example, differs from normal triplet oxygen (free-radical ground state) by virtue of its increased reactivity. However, activated, reactive (free-radical) triplet states of the oxygen molecule also exist.
Furthermore, UV radiation is a form of ionizing radiation. There is therefore the risk that ionic species will also form during UV exposure, which then for their part are able to intervene oxidatively in the biochemical processes.
One applications-relevant disadvantage of many UV filters is their poor solubility in water and/or in natural and synthetic oils, for example in silicone oils and in fatty acid triglycerides, as a result of which their use, for example in cosmetic formulations, is often restricted.
A further disadvantage associated with the application of some photoprotective agents is the appearance of skin irritations and allergies resulting from too high a skin permeability.
Numerous methods have already been published for improving the formulation properties of insoluble or only sparingly soluble UV absorbers.
For example, GB-A-2 303 549 describes a grinding process for the preparation of micronized insoluble organic UV absorbers in the presence of alkyl polyglycosides. The resulting micronizates can be incorporated into cosmetic photoprotective preparations.
GB-A-2 286 774 likewise describes a grinding process for the micronization of insoluble organic UV absorbers.
EP-A-1 127 567 describes aqueous dispersions of sparingly water-soluble or water-insoluble organic UV filter substances and dry powders produced therefrom, wherein they comprise at least one sparingly water-soluble or water-insoluble organic UV filter substance as colloidally disperse phase in amorphous of partially amorphous form. The use of the protective colloids specified in this specification - in particular gelatin or casein or caseinate - leads to powdered products whose solubility in cold water is unsatisfactory. In addition, gelatin and casein in cosmetic formulations can cause skin allergies.
It was then an object of the present invention to provide a method of producing triazine-containing photoprotective agent formulations which offer effective protection for organic material, in particular for the human skin and/or human hair, against UV rays, which are well tolerated by the skin and which can be incorporated easily both into lipophilic and also in particular into aqueous systems.
This object was achieved by a method of producing powdered preparations comprising 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)-1,3,5-triazine of the formula I
IzHs H9C4 HC- HzCOOC / ~ NH CzHs ~--N
CzHS N~ ~-NH~COOCHz -CH-C4H9 N
N
H9C4 HC- H2COOC~ H
by a) dispersing the triazine I in an aqueous molecularly disperse or colloidally disperse solution of a protective colloid and b) converting the dispersion obtained into a dry powder by removing the water and, if appropriate, additionally used solvents, and drying, wherein the protective colloid used in process step a) is modified starch.
2,4,6-Trianilino-p-(carbo-2'-ethylhexyl-1 '-oxy)-1,3,5-triazine of the formula I is marketed by BASF Aktiengesellschaft under the trade name Uvinul~ T150 as a UVB
filter. Uvinul~ T150 is notable, inter alia, for good UV absorption properties with an exceptionally high absorbance coefficient > 1500 at 314 nm.
For the purposes of the present invention, the term aqueous dispersions is understood as meaning both aqueous suspensions and emulsions. Preferred aqueous suspensions which may be mentioned are those in which the disperse phase comprises the triazine I as nanoparticulate particles.
For the purposes of the present invention, the term modified starch preferably comprises esters of starch with organic acids, e.g. with acetic acid and higher fatty acids (C6-Czs), and with succinic acid, adipic acid and citric acid. The starch can be obtained here, inter alia, from corn, potatoes or wheat. A particularly preferred modified starch is octenyl succinate starch, which is marketed under the trade name HiCap~ by National Starch or EmCap~ by Cerestar.
A preferred variant of the method according to the invention is one in which the dispersion in stage a) comprises the following steps:
a,) dissolving the triazine I in one or more water-miscible organic solvents) or in a mixture of water and one or more water-miscible organic solvents) or a2) dissolving the triazine I in one or more water-immiscible organic solvents) and a3) mixing the solution obtained after a,) or a2) with an aqueous molecularly disperse or colloidally disperse solution of modified starch, where the hydrophobic phase of the triazine I is formed as nanodisperse phase.
Depending on the type of solvent used, the nanodisperse phase in step a3) may be solid nanoparticles [suspension; obtainable by combining a,) and a3)] or nanodroplets [emulsion; obtainable by combining a2) and a3)].
The water-miscible solvents used in stage a,) are primarily water-miscible, thermally stable, volatile solvents comprising only carbon, hydrogen and oxygen, such as alcohols, ethers, esters, ketones and acetals. It is expedient to use those solvents which are at least 10°I° water-miscible, have a boiling point below 200°C, preferably below 100°C, and/or have fewer than 10 carbons. Particular preference is given to methanol, ethanol, n-propanol, isopropanol, 1,2-butanediol 1-methyl ether, 1,2-propanediol 1-n-propyl ether, tetrahydrafuran or acetone or mixtures thereof, and very particular preference is given to using isopropanol or acetone.
For the purposes of the present invention, the term "a water-immiscible organic solvent" is an organic solvent with a solubility in water at atmospheric pressure of less than 10%. Suitable possible solvents here are, inter alia, hafogenated aliphatic hydrocarbons, such as, for example, methylene chloride, chloroform or carbon tetrachloride, carboxylic acid esters, such as diethyl carbonate, ethyl formate, methyl, ethyl or isopropyl acetate, and ethers, such as methyl tert-butyl ether.
Preferred water-immiscible organic solvents are the following compounds from the group consisting of dimethyl carbonate, propylene carbonate, ethyl formate, ethyl acetate, isopropyl acetate and methyl tert-butyl ether.
The dry powder in process step b) can be produced here, inter alia, by spray-drying, spray-cooling, freeze-drying, and by drying in a fluidized bed, convection drying or contact drying, it also being possible to carry out the drying in the presence of a coating material (powdering agent). Suitable coating agents are, inter alia, corn starch, silica +0 and also tricalcium phosphate.
During the lyophilization of the nanoparticles according to the invention, cryoprotective substances such as, for example, trehalose or polyvinylpyrrolidones, can be added to the nanoparticles according to the invention.
a,) dissolving the triazine I in one or more water-miscible organic solvents) or in a mixture of water and one or more water-miscible organic solvents) or a2) dissolving the triazine I in one or more water-immiscible organic solvents) and a3) mixing the solution obtained after a,) or a2) with an aqueous molecularly disperse or colloidally disperse solution of modified starch, where the hydrophobic phase of the triazine I is formed as nanodisperse phase.
Depending on the type of solvent used, the nanodisperse phase in step a3) may be solid nanoparticles [suspension; obtainable by combining a,) and a3)] or nanodroplets [emulsion; obtainable by combining a2) and a3)].
The water-miscible solvents used in stage a,) are primarily water-miscible, thermally stable, volatile solvents comprising only carbon, hydrogen and oxygen, such as alcohols, ethers, esters, ketones and acetals. It is expedient to use those solvents which are at least 10°I° water-miscible, have a boiling point below 200°C, preferably below 100°C, and/or have fewer than 10 carbons. Particular preference is given to methanol, ethanol, n-propanol, isopropanol, 1,2-butanediol 1-methyl ether, 1,2-propanediol 1-n-propyl ether, tetrahydrafuran or acetone or mixtures thereof, and very particular preference is given to using isopropanol or acetone.
For the purposes of the present invention, the term "a water-immiscible organic solvent" is an organic solvent with a solubility in water at atmospheric pressure of less than 10%. Suitable possible solvents here are, inter alia, hafogenated aliphatic hydrocarbons, such as, for example, methylene chloride, chloroform or carbon tetrachloride, carboxylic acid esters, such as diethyl carbonate, ethyl formate, methyl, ethyl or isopropyl acetate, and ethers, such as methyl tert-butyl ether.
Preferred water-immiscible organic solvents are the following compounds from the group consisting of dimethyl carbonate, propylene carbonate, ethyl formate, ethyl acetate, isopropyl acetate and methyl tert-butyl ether.
The dry powder in process step b) can be produced here, inter alia, by spray-drying, spray-cooling, freeze-drying, and by drying in a fluidized bed, convection drying or contact drying, it also being possible to carry out the drying in the presence of a coating material (powdering agent). Suitable coating agents are, inter alia, corn starch, silica +0 and also tricalcium phosphate.
During the lyophilization of the nanoparticles according to the invention, cryoprotective substances such as, for example, trehalose or polyvinylpyrrolidones, can be added to the nanoparticles according to the invention.
5 Particular preference is given to an embodiment of the method according to the invention in which a,) the triazine I is dissolved in acetone or isopropanol or a mixture of water and acetone or water and isopropanol at temperatures in the range from 50 to 240°C, a3) the solution obtained is mixed with an aqueous molecularly disperse or colloidally disperse solution of modified starch, in particular octenyf succinate starch, at temperatures in the range from 25 to 120°C and b) the suspension formed is spray-dried after removing the organic solvent.
The abovementioned dry powders are advantageously produced by dissolving the triazine of the formula I in acetone or isopropanol or a mixture of water and acetone or water and isopropanol at temperatures in the range from 50°C to 240°C, in particular 100°C to 200°C, particularly preferably in the range from 105°C to 180°C.
To produce the molecularly disperse solution rapidly, the application of increased pressure, e.g. in the range from 20 bar to 80 200 bar, preferably 30 to 100 bar, may be advantageous.
The molecularly disperse solution obtained in this way is then mixed directly with the, if appropriate cooled, aqueous molecularly disperse or colloidally disperse solution of the modified starch, in particular octenyl succinate starch, in such a way that a mixing temperature of about 25°C to 120°C, preferably 40°C to 80°C, particularly preferably 45°C to 70°C, is established.
In so doing, the solvent component is converted into the aqueous phase and the hydrophobic phase of the triazine is formed as nanodisperse phase.
The mixing in step a3) can be carried out by initially introducing the solution comprising triazine, and metering in the aqueous solution of modified starch, or vice versa, or preferably by metering in both solutions simultaneously and continuously into a mixing chamber.
With regard to a more detailed description of the method and apparatus relating to the abovementioned dispersion, reference is made at this point to EP-B-0 065 193.
s To increase the mechanical stability of the end product, in some cases it may be advantageous to add a further plasticizer to the colloid, such as sugars or sugar alcohols, e.g. sucrose, glucose, glucose syrup, dextrin, inverted sugar, sorbitol, mannitol or glycerol.
To increase the stability of the active ingredient against oxidative degradation, it may likewise be expedient to add stabilizers such as a-tocopherol, t-butylhydroxytoluene, t-butylhydroxyanisofe, ascorbic acid or ethoxyquin. They can either be added to the aqueous phase or to the solvent phase, although they are preferably dissolved together with the triazine 1 in the solvent phase.
In addition, the photoprotective agent formulations can comprise low molecular weight surface-active compounds (emulsifiers) in a concentration of from 0.01 to 70%
by weight, preferably 0.1 to 50% by weight, particularly preferably 0.5 to 20% by weight, based on the dry mass of the photoprotective agent formulation. Suitable as such are primarily amphiphilic compounds or mixtures of such compounds. In principle, all surfactants with an HLB value of from 5 to 20 are suitable. Suitable corresponding surface-active substances are, for example: esters of long-chain fatty acids with ascorbic acid, mono- and diglycerides of fatty acids and oxymethylation products thereof, esters of monofatty acid glycerides with acetic acrd, citric acid, lactic acid or diacetyltartaric acid, polyglycerol fatty acid esters, such as, for example, the monostearate of triglycerol, sorbitan fatty acid esters, propylene glycol fatty acid esters and lecithin. Preference is given to using ascorbyl palmitate.
To increase the stability of the active ingredient against microbial degradation, it may be expedient to add preservatives to the preparation, such as, for example, methyl 4-hydroxybenzoate, propyl 4-hydroxybenzoate, sorbic acid or benzoic acid or salts thereof.
According to the invention, dry powders can thus be obtained which no longer lose their properties obtained in the primary dispersion. This means that the amorphous or partially crystalline character of the UV filter substance is retained. It is also a property according to the invention that these powders, upon redispersion, have the same particle size distribution which they had as primary dispersion with a deviation of 20%, preferably < 15°!°.
A further preferred embodiment of the abovementioned method is one in which the suspension prepared in process step a) is ground before being converted into a dry powder.
The grinding method is preferably carried out by suspending the triazine I in crystalline form in an aqueous molecularly disperse or colloidally disperse solution of modified starch, and comminuting to the desired particle size by grinding.
The grinding can be carried out here in a manner known per se, e.g. using a ball mill.
Depending on the type of mill used, grinding is carried out until the particles have an average particle size, determined via Fraunhofer diffraction, D[4.3] of from 0.01 to 100 Nm, preferably from 0.02 to 50 Nm, particularly preferably 0.05 to 20 Nm, very particularly preferably 0.05 to 5 Nm, in particular 0.1 to 1 Nm. The term D[4.3] refers to the volume-weighted average diameter (see handbook for Malvern Mastersizer S, Malvern Instruments Ltd., UK).
By heating the aqueous suspension after the grinding process to a temperature above the melting point of the triazine I and then spray-drying the "melt emulsion", it is possible to increase the amorphous fraction of the triazine in the resulting dry powder.
Details regarding the grinding of active ingredients in aqueous protective colloid solutions are given in EP-B-0 498 824 and EP-B-0 684 973.
The invention also provides triazine-comprising powdered preparations obtainable by the abovementioned methods.
The novel photoprotective agent formulations are notable for the fact that they comprise the triazine of the formula I, the amorphous fraction of which is in the range greater than 10%, preferably greater than 30%, particularly preferably in the range from 50 to 100%, very particularly preferably in the range from 75 to 99%. The degree of crystallinity of the triazine I can be determined here, for example, by X-ray diffraction measurements.
The content of triazine of the formula I in the photoprotective agent formulations according to the invention is in the range from 0.1 to 70% by weight, preferably in the range from 2 to 40% by weight, particularly preferably in the range from 3 to 30% by weight, very particularly preferably in the range from 5 to 25% by weight, based on the dry mass of the formulations.
The average particle size D[4.3] of the nanoparticulate particles in the aqueous dispersion is, depending on the formulation method, in the range from 0.01 to 100 Nm, preferably in the range from 0.02 to 50 Nm, particularly preferably in the range from 0.05 to 20 Nm, very particularly preferably in the range from 0.05 to 5 Nm, in particular 0.1 to 1 Nm.
Whereas ground UV filter substances, when incorporated into skin creams, have an increased propensity for particle size growth, which can lead to a deterioration of the sun protection factor and to an unpleasant feel on the skin, the dry powders according to the invention do not have such tendencies on account of their matrix and protective colloid structure.
The formulations according to the invention - dispersions and dry powders prepared therefrom - are highly suitable for stabilizing organic material inter alia against the effect of light, oxygen and heat. They are added to the organic material to be stabilized in a concentration of from 0.01 to 10°!o by weight, preferably 0.01 to 5% by weight, particularly preferably from 0.02 to 2°I° by weight, based on the organic material, before, during or after its preparation.
Organic material is understood as meaning, for example, photographic recording materials, in particular photographic emulsions or precursors for plastics and surface coatings, but in particular plastics and surface coatings themselves.
Organic material, however, also means cosmetic preparations, such as, for example, creams, lotions, gels, lipsticks.
The present invention further relates to organic material stabilized against the action of light, oxygen and heat, in particular plastics and surface coatings, comprising 0.01 to 10% by weight, preferably 0.01 to 5°!° by weight, particularly preferably from 0.02 to 2%
by weight, based on the total amount of the organic material, of the triazine I in the form of the formulations according to the invention.
For mixing the formulations according to the invention primarily with plastics, it is possible to use all known devices and methods for mixing stabilizing agents or other additives into polymers.
The organic material stabilized by the formulations according to the invention can, if appropriate, comprise further additives, e.g. antioxidants, light stabilizing agents, metal deactivators, antistatic agents, flame retardants, pigments and fillers.
Antioxidants and light stabilizers which can be added in addition to the formulations according to the invention are, for example, compounds based on sterically hindered phenols or costabilizers comprising sulfur or phosphorus.
Examples of such phenolic antioxidants are 2,6-di-tert-butyl-4-methylphenol, n-octadecyl-(3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate, 1,1,3-tris(2-methyl-4-hydroxy-5-tert-butylphenyl)butane, 1,3,5-trimethyl-2,4,6-tris(3,5-di-tert-butyl-4-hydroxybenzyl)-benzene, 1,3,5-tris(3,5-di-tert-butyl-4-hydroxybenzyl) isocyanurate, 1,3,5-tris[(3-(3,5-di-tert-butyl-4- hydroxyphenyl)propionylethyl]
isocyanurate, 1,3,5-tris(2,6-dimethyl-3-hydroxy-4-tert-butylbenzyl) isocyanurate and pentaerythritol tetrakis-[(3-(3,5-di-tert-butyl- 4-hydroxyphenyl) propionate].
Examples of suitable phosphorus-comprising antioxidants are tris(nonylphenyl) phosphate, distearylpentaerythritol diphosphite, tris(2,4-di-tert-butylphenyl) phosphate, tris(2-tert-butyl-4-methylphenyl) phosphate, bas(2,4-di-tert-butylphenyl)pentaerythritol diphosphite and tetrakis(2,4-di-tert-butylphenyl) 4,4'-biphenylenediphosphite.
Examples of sulfur-comprising antioxidants are dilauryl thiodipropionate, dimyristyl thiodipropionate, distearyl thiodipropionate, pentaerythritol tetrakis(a-laurylthiopropionate) and pentaerythritol tetrakis-((3-hexylthiopropionate).
Other antioxidants and light stabilizers which can be used together with the formulations according to the invention are, for example, 2-(2'-hydroxyphenyl)-benzotriazoles, 2-hydroxybenzophenones, aryl esters of hydroxybenzoic acids, a-cyanocinnamic acid derivatives, benzimidazolecarboxanilides, nickel compounds or oxalanilides.
Particularly good stabilization is achieved when at feast one light stabilizer from the compound class of sterically hindered amines is also added in the usual concentration to the formulations according to the invention.
Examples of suitable sterically hindered amines are: bas(2,2,6,6-tetramethylpiperidyl) sebacate, bas(1,2,2,6,6-pentamethylpiperidyl) sebacate, the condensation product of 1-hydroxyethyl-2,2,6,6-tetramethyl-4-hydroxypiperidine and succinic acid, the condensation product of N,N'-di(2,2,6,6-tetramethylpiperidyl)hexamethylenediamine and 4-tert-octylamino-2,6-dichloro-1,3,5-triazine, tris(2,2,6,6-tetramethylpiperidyl) nitrilotriacetate, tetrakis(2,2,6,6-tetramethyl-4-piperidyl) 1,2,3,4-butanetetracarboxylate, 1,1'-(1,2-ethanediyl)-bas(3,3,5,5-tetramethylpiperazinone), the condensation products of 4-amino-2,2,6,6-tetramethylpiperidines and tetramethylolacetylenediureas.
Examples of plastics which can be stabilized by the compounds I according to the invention and may be mentioned are:
polymers of mono- and diolefins, such as, for example, low density or high density polyethylene, polypropylene, linear poly-1-butene, polyisoprene, polybutadiene, and copolymers of mono- or diolefins or mixtures of said polymers;
copolymers of mono- or diofefins with other vinyl monomers, such as, for example, ethylene/alkyl acrylate copolymers, ethylene/alkyl methacrylate copolymers, ethylene/vinyl acetate copolymers or ethylene/acrylic acid copolymers;
polystyrene and copolymers of styrene or -a-methylstyrene with dienes and/or acrylic derivatives, such as, for example, styrene/butadiene, styrene/acrylonitrile (SAN), styrene/ethyl methacrylate, styrene/butadiene/ethyl acrylate, styrene/acryfonitrilelmethacrylate, acrylonitrile/butadienelstyrene (ABS) or methyl methacrylate/butadiene/styrene (MBS);
halogen-containing polymers, such as, for example, polyvinyl chloride, polyvinyl fluoride, polyvinylidene fluoride and copolymers thereof;
polymers derived fram a,f3-unsaturated acids and derivatives thereof, such as polyacrylates, polymethacrylates, polyacrylamides and polyacrylonitriles;
polymers derived from unsaturated alcohols and amines or acyl derivatives or acetals 5 thereof, e.g. polyvinyl alcohol and polyvinyl acetate;
polyurethanes, polyamides, polyureas, polyesters, polycarbonates, polysulfonates, polyether sulfones and polyether ketones.
10 Furthermore, the formulations according to the invention can be used to stabilize aqueous emulsion paints and surface coatings, e.g. industrial finishes. Of these, particular attention is drawn to baking finishes, and, in turn, of these, automotive finishes, preferably two-coat finishes.
The formulations can be added in solid or liquid form to the surface coating.
Their good solubility in surface coating systems is of particular advantage here.
Even in the case of the use as stabilizers in surface coatings, it is possible also to use the additional additives already listed, in particular antioxidants and light stabilizers.
The photoprotective agent formulations according to the invention are also very particularly preferably suitable as photostable UV filters in cosmetic and dermatological preparations for protecting human skin or human hair from solar rays and also from artificial light which has high UV contents, alone or together with compounds which absorb in the UV region and are known for cosmetic or pharmaceutical preparations.
Thus, in the widest sense, the term organic materials also means human skin and human hair. The cosmetic and pharmaceutical preparations as such are of course also stabilized at the same time in order to remain effective for as long as possible.
Accordingly, the present invention also relates to cosmetic and pharmaceutical preparations comprising photoprotective agents for protecting human skin or human hair from UV light in the range from 280 to 400 nm, which comprise, as photostable UV
filters and in a cosmetically or pharmaceutically suitable carrier, effective amounts of a formulation of the triazine I in amorphous or partially amorphous form - alone or together with compounds which absorb in the UV-A and UV-B region and are known per se for cosmetic and pharmaceutical preparations - the formulations being aqueous dispersions according to the invention mentioned in the introduction or the dry powders prepared therefrom.
The amount of triazine I in the form of the formulations according to the invention which is used in the cosmetic and pharmaceutical preparations is in the range from 0.05 to 20% by weight, preferably 0.1 to 10% by weight, particularly preferably in the range from 1 to 7°1° by weight, based on the total amount of the cosmetic and pharmaceutical preparation.
The cosmetic and pharmaceutical preparations comprising photoprotective agents are generally based on a carrier which comprises at least one oil phase.
Preparations based solely on aqueous components are, however, also possible. Accordingly, suitable preparations are oils, oil-in-water and water-in-oil emulsions, creams and pastes, lip-protection stick compositions or grease-free gels.
Suitable emulsions are inter alia also ONV macroemulsions, O/W microemulsions or O1V11/O emulsions containing triazine of the formula I present in dispersed form, the emulsions being obtainable by phase inversion technology, as in DE-A-197 26 121.
Customary cosmetic auxiliaries which may be suitable as additives are, for example, coemulsifiers, fats and waxes, stabilizers, thickeners, biogenic active ingredients, film formers, fragrances, dyes, pearlizing agents, preservatives, pigments, electrolytes (e.g.
magnesium sulfate) and pH regulators. Suitable coemulsifiers are, preferably, known W/O and also O/1N emulsifiers, such as, for example, polyglycerol esters, sorbitan esters or partially esterified glycerides. Typical examples of fats are glycerides; waxes which may be mentioned are inter alia beeswax, paraffin wax or microcrystalline waxes, if appropriate in combination with hydrophilic waxes. Stabilizers which may be used are metal salts of fatty acids, such as, for example, magnesium, aluminum and/or zinc stearate. Examples of suitable thickeners are crosslinked polyacrylic acids and derivatives thereof, polysaccharides, in particular xanthan gum, guar guar, agar agar, alginates and tyloses, carboxymethylcellulose and hydroxyethylcellulose, and also fatty alcohols, monoglycerides and fatty acids, polycrylates, polyvinyl alcohol and polyvinylpyrrolidone. The term biogenic active ingredients means, for example, plant extracts, protein hydrolyzates and vitamin complexes. Customary film formers are, for example, hydrocolloids, such as chitosan, microcrystalline chitosan or quaternary chitosan, polyvinylpyrrolidone, vinylpyrrolidone/vinyl acetate copolymers, polymers of the acrylic acid series, quaternary cellulose derivatives and similar compounds.
Examples of suitable preservatives are formaldehyde solution, p-hydroxybenzoate or sorbic acid. Examples of suitable pearlizing agents are glycol distearic esters, such as ethylene glycol distearate, but also fatty acids and fatty acid monoglycol esters. Dyes which may be used are the substances suitable and approved for cosmetic purposes, as listed, for example, in the publication "Kosmetische Farbemittel" [Cosmetic Colorants] from the Farbstoffkommission der Deutschen Forschungsgemeinschaft [Dyes Commission of the German Research Council], published by Verlag Chemie, Weinheim, 1984. These dyes are usually used in a concentration of from 0.001 to 0.1 by weight, based on the total mixture.
An additional content of antioxidants is generally preferred. Thus, favorable antioxidants which can be used ace all antioxidants which are suitable or customary for cosmetic and/or dermatological applications.
The antioxidants are advantageously chosen from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and derivatives thereof, imidazoles (e.g.
urocanic acid) and derivatives thereof, peptides such as D,L-carnosine, D-carnosine, L-carnosine and derivatives thereof (e.g. anserine), carotenoids, carotene (e.g. (3-carotene, lycopene) and derivatives thereof, chlorogenic acid and derivatives thereof, lipoic acid and derivatives thereof (e.g. dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (e.g. thiorodoxin, glutathione, cysteine, cystine, cystamine and the glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, y-linoleyl, cholesteryl and glyceryl esters thereof) and salts thereof, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (e.g. buthionine sulfoximines, homocysteine sulfoximines, buthionine sulfones, yenta-, hexa-, heptathionine sulfoximine) in very low tolerated doses (e.g. pmol to Nmollkg), also (metal) cheiating agents (e.g. a-hydroxyfatty acids, palmitic acid, phytic acid, lactoferrin), a-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA and derivatives thereof, unsaturated fatty acids and derivatives thereof (e.g. y-linolenic acid, linoleic acid, oleic acid), folic acid and derivatives thereof, ubiquinone and ubiquinol and derivatives thereof, vitamin C and derivatives thereof (e.g. ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherol and derivatives (e.g.
vitamin E
acetate, tocotrienol}, vitamin A and derivatives (vitamin A palmitate) and coniferyl benzoate of benzoin resin, rutic acid and derivatives thereof, a-glycosyfrutin, ferulic acid, furfurylideneglucitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiac resin acid, nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and derivatives thereof, mannose and derivatives thereof, zinc and derivatives thereof (e.g. ZnO, ZnS04), selenium and derivatives thereof (e.g.
selenomethionine), stilbenes and derivatives thereof (e.g. stilbene oxide, trans-stilbene oxide}.
The amount of the abovementioned antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.05 to 20°t°
by weight, in particular 1 to 10% by weight, based on the total weight of the preparation.
If vitamin E and/or derivatives thereof are the antioxidant or antioxidants, it is advantageous to choose the respective concentration thereof from the range 0.001 to 10% by weight, based on the total weight of the formulation.
If vitamin A and/or derivatives thereof or carotenoids are the antioxidant or antioxidants, it is advantageous to choose the respective concentration thereof from the range 0.001 to 10% by weight, based on the total weight of the formulation.
Customary oil components in cosmetics are, for example, silicone oils, paraffin oil, glyceryl stearate, isopropyl myristate, diisopropyl adipate, cetylstearyl 2-ethylhexanoate, hydrogenated polyisobutene, vaseline, capryliclcapric triglycerides, microcrystalline wax, lanolin and stearic acid.
The total proportion of auxiliaries and additives can be 1 to 80% by weight, preferably 6 to 40% by weight, and the nonaqueous proportion ("active substance") can be 20 to 80% by weight, preferably 30 to 70% by weight, based on the compositions. The compositions can be prepared in a manner known per se, i.e. for example by hot, cold, hot-hotlcold or PIT emulsification. This is a purely mechanical process, and no chemical reaction takes place.
Such sunscreen preparations can accordingly be in liquid, paste or solid form, for example as water-in-oil creams, oil-in-Water creams and lotions, aerosol foam creams, gels, oils, marking pencils, powders, sprays or alcohol-aqueous lotions.
Finally, it is possible additionally to use further substances known per se which absorb in the UV region, provided they are stable in the overall system of the combination of UV filters to be used according to the invention.
The majority of photoprotective agents in the cosmetic and pharmaceutical preparations used to protect the human epidermis consists of compounds which absorb UV fight in the UV-B region, i.e. in the range from 280 to 320 nm. For example, the proportion of the UV-A absorbers to be used according to the invention is 10 to 90% by weight, preferably 20 to 50% by weight, based on the total amount of UV-B and UV-A absorbing substances.
Suitable UV filter substances which are used in combination with the formulations to be used according to the invention are any UV-A and UV-B filter substances.
Examples which may be mentioned are:
No Substance CAS No.(=acid) 1 4-Aminobenzoic acid 150-13-0 2 3-(4'-Trimethylammonium)benzylidenebornan-2-one52793-97-2 I methylsulfate 3 3,3,5-Trimethylcyclohexyl salicylate(homosalate)118-56-9 4 2-Hydroxy-4-methoxybenzophenone(oxybenzone) 131-57-7 5 2-Phenylbenzimidazole-5-sulfonic acid and 27503-81-7 its potassium, sodium and triethanolamine salts 6 3,3'-(1,4-Phenylenedimethine}-bis(7,7-dimethyl-2-90457-82-2 oxobicyclo[2.2.1]heptane-1-methanesulfonic acid) and its salts 7 Polyethoxyethyl4-bis(polyethoxy)aminobenzoate113010-52-9 8 2-Ethylhexyl4-dimethylaminobenzoate 21245-02-3 9 2-Ethylhexyl salicylate 118-60-5 10 2-Isoamyl4-methoxycinnamate 71617-10-2 11 2-Ethylhexyl 4-methoxycinnamate 5466-77-3 12 2-Hydroxy-4-methoxybenzophenone-5-sulfonic 4065-45-6 acid (sulisobenzone) and the sodium salt 13 3-(4'-Sulfobenzylidene)bornan-2-one and salts58030-58-6 14 3-Benzylidenebornan-2-one 16087-24-8 15 1-(4'-Isopropylphenyl~--3-phenylpropane-1,3--dione63260-25-9 16 4-Isopropylbenzyl salicylate 94134-93-7 17 3-Imidazol--~-ylacrylic acid and its ethyl ~ 104-98-3 ester 18 Ethyl2-cyano-3,3-diphenylacrylate 5232-99-5 19 2'-Ethylhexyl2-cyano-3,3-~iiphenylacrylate 6197-30-4 20 Menthyl o-aminobenzoate or:5-methyl-2-(1-methylethyl}-2-134-09-8 aminobenzoate 21 Glyceryl p-aminobenzoate or:1-glyceryl 4-aminobenzoate136-44-7 22 2,2'-Dihydroxy-4-methoxybenzophenone (dioxybenzone)131-53-3 23 2-Hydroxy-d-methoxy-4-methylbenzophenone (mexenone)1641-17-4 24 Triethanolamine salicylate 2174-16-5 25 Dimethoxyphenylglyoxalic acid or sodium 3,4- 4732-70-1 dimethoxyphenylglyoxalate 26 3-(4'-Sulfobenzylidene)bornan-2-one and its 56039-58-8 salts 27 4-tert-Butyi-4'-methoxydibenzoylmethane 70356-09-1 28 2,2',4,4'-Tetrahydroxybenzophenone 131-55-5 29 2,2'-Methylenebis[6(2H-benzotriazol-2-y1~4-(1,1,3,3-103597-45-1 tetramethylbutyl)phenolJ
The abovementioned dry powders are advantageously produced by dissolving the triazine of the formula I in acetone or isopropanol or a mixture of water and acetone or water and isopropanol at temperatures in the range from 50°C to 240°C, in particular 100°C to 200°C, particularly preferably in the range from 105°C to 180°C.
To produce the molecularly disperse solution rapidly, the application of increased pressure, e.g. in the range from 20 bar to 80 200 bar, preferably 30 to 100 bar, may be advantageous.
The molecularly disperse solution obtained in this way is then mixed directly with the, if appropriate cooled, aqueous molecularly disperse or colloidally disperse solution of the modified starch, in particular octenyl succinate starch, in such a way that a mixing temperature of about 25°C to 120°C, preferably 40°C to 80°C, particularly preferably 45°C to 70°C, is established.
In so doing, the solvent component is converted into the aqueous phase and the hydrophobic phase of the triazine is formed as nanodisperse phase.
The mixing in step a3) can be carried out by initially introducing the solution comprising triazine, and metering in the aqueous solution of modified starch, or vice versa, or preferably by metering in both solutions simultaneously and continuously into a mixing chamber.
With regard to a more detailed description of the method and apparatus relating to the abovementioned dispersion, reference is made at this point to EP-B-0 065 193.
s To increase the mechanical stability of the end product, in some cases it may be advantageous to add a further plasticizer to the colloid, such as sugars or sugar alcohols, e.g. sucrose, glucose, glucose syrup, dextrin, inverted sugar, sorbitol, mannitol or glycerol.
To increase the stability of the active ingredient against oxidative degradation, it may likewise be expedient to add stabilizers such as a-tocopherol, t-butylhydroxytoluene, t-butylhydroxyanisofe, ascorbic acid or ethoxyquin. They can either be added to the aqueous phase or to the solvent phase, although they are preferably dissolved together with the triazine 1 in the solvent phase.
In addition, the photoprotective agent formulations can comprise low molecular weight surface-active compounds (emulsifiers) in a concentration of from 0.01 to 70%
by weight, preferably 0.1 to 50% by weight, particularly preferably 0.5 to 20% by weight, based on the dry mass of the photoprotective agent formulation. Suitable as such are primarily amphiphilic compounds or mixtures of such compounds. In principle, all surfactants with an HLB value of from 5 to 20 are suitable. Suitable corresponding surface-active substances are, for example: esters of long-chain fatty acids with ascorbic acid, mono- and diglycerides of fatty acids and oxymethylation products thereof, esters of monofatty acid glycerides with acetic acrd, citric acid, lactic acid or diacetyltartaric acid, polyglycerol fatty acid esters, such as, for example, the monostearate of triglycerol, sorbitan fatty acid esters, propylene glycol fatty acid esters and lecithin. Preference is given to using ascorbyl palmitate.
To increase the stability of the active ingredient against microbial degradation, it may be expedient to add preservatives to the preparation, such as, for example, methyl 4-hydroxybenzoate, propyl 4-hydroxybenzoate, sorbic acid or benzoic acid or salts thereof.
According to the invention, dry powders can thus be obtained which no longer lose their properties obtained in the primary dispersion. This means that the amorphous or partially crystalline character of the UV filter substance is retained. It is also a property according to the invention that these powders, upon redispersion, have the same particle size distribution which they had as primary dispersion with a deviation of 20%, preferably < 15°!°.
A further preferred embodiment of the abovementioned method is one in which the suspension prepared in process step a) is ground before being converted into a dry powder.
The grinding method is preferably carried out by suspending the triazine I in crystalline form in an aqueous molecularly disperse or colloidally disperse solution of modified starch, and comminuting to the desired particle size by grinding.
The grinding can be carried out here in a manner known per se, e.g. using a ball mill.
Depending on the type of mill used, grinding is carried out until the particles have an average particle size, determined via Fraunhofer diffraction, D[4.3] of from 0.01 to 100 Nm, preferably from 0.02 to 50 Nm, particularly preferably 0.05 to 20 Nm, very particularly preferably 0.05 to 5 Nm, in particular 0.1 to 1 Nm. The term D[4.3] refers to the volume-weighted average diameter (see handbook for Malvern Mastersizer S, Malvern Instruments Ltd., UK).
By heating the aqueous suspension after the grinding process to a temperature above the melting point of the triazine I and then spray-drying the "melt emulsion", it is possible to increase the amorphous fraction of the triazine in the resulting dry powder.
Details regarding the grinding of active ingredients in aqueous protective colloid solutions are given in EP-B-0 498 824 and EP-B-0 684 973.
The invention also provides triazine-comprising powdered preparations obtainable by the abovementioned methods.
The novel photoprotective agent formulations are notable for the fact that they comprise the triazine of the formula I, the amorphous fraction of which is in the range greater than 10%, preferably greater than 30%, particularly preferably in the range from 50 to 100%, very particularly preferably in the range from 75 to 99%. The degree of crystallinity of the triazine I can be determined here, for example, by X-ray diffraction measurements.
The content of triazine of the formula I in the photoprotective agent formulations according to the invention is in the range from 0.1 to 70% by weight, preferably in the range from 2 to 40% by weight, particularly preferably in the range from 3 to 30% by weight, very particularly preferably in the range from 5 to 25% by weight, based on the dry mass of the formulations.
The average particle size D[4.3] of the nanoparticulate particles in the aqueous dispersion is, depending on the formulation method, in the range from 0.01 to 100 Nm, preferably in the range from 0.02 to 50 Nm, particularly preferably in the range from 0.05 to 20 Nm, very particularly preferably in the range from 0.05 to 5 Nm, in particular 0.1 to 1 Nm.
Whereas ground UV filter substances, when incorporated into skin creams, have an increased propensity for particle size growth, which can lead to a deterioration of the sun protection factor and to an unpleasant feel on the skin, the dry powders according to the invention do not have such tendencies on account of their matrix and protective colloid structure.
The formulations according to the invention - dispersions and dry powders prepared therefrom - are highly suitable for stabilizing organic material inter alia against the effect of light, oxygen and heat. They are added to the organic material to be stabilized in a concentration of from 0.01 to 10°!o by weight, preferably 0.01 to 5% by weight, particularly preferably from 0.02 to 2°I° by weight, based on the organic material, before, during or after its preparation.
Organic material is understood as meaning, for example, photographic recording materials, in particular photographic emulsions or precursors for plastics and surface coatings, but in particular plastics and surface coatings themselves.
Organic material, however, also means cosmetic preparations, such as, for example, creams, lotions, gels, lipsticks.
The present invention further relates to organic material stabilized against the action of light, oxygen and heat, in particular plastics and surface coatings, comprising 0.01 to 10% by weight, preferably 0.01 to 5°!° by weight, particularly preferably from 0.02 to 2%
by weight, based on the total amount of the organic material, of the triazine I in the form of the formulations according to the invention.
For mixing the formulations according to the invention primarily with plastics, it is possible to use all known devices and methods for mixing stabilizing agents or other additives into polymers.
The organic material stabilized by the formulations according to the invention can, if appropriate, comprise further additives, e.g. antioxidants, light stabilizing agents, metal deactivators, antistatic agents, flame retardants, pigments and fillers.
Antioxidants and light stabilizers which can be added in addition to the formulations according to the invention are, for example, compounds based on sterically hindered phenols or costabilizers comprising sulfur or phosphorus.
Examples of such phenolic antioxidants are 2,6-di-tert-butyl-4-methylphenol, n-octadecyl-(3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate, 1,1,3-tris(2-methyl-4-hydroxy-5-tert-butylphenyl)butane, 1,3,5-trimethyl-2,4,6-tris(3,5-di-tert-butyl-4-hydroxybenzyl)-benzene, 1,3,5-tris(3,5-di-tert-butyl-4-hydroxybenzyl) isocyanurate, 1,3,5-tris[(3-(3,5-di-tert-butyl-4- hydroxyphenyl)propionylethyl]
isocyanurate, 1,3,5-tris(2,6-dimethyl-3-hydroxy-4-tert-butylbenzyl) isocyanurate and pentaerythritol tetrakis-[(3-(3,5-di-tert-butyl- 4-hydroxyphenyl) propionate].
Examples of suitable phosphorus-comprising antioxidants are tris(nonylphenyl) phosphate, distearylpentaerythritol diphosphite, tris(2,4-di-tert-butylphenyl) phosphate, tris(2-tert-butyl-4-methylphenyl) phosphate, bas(2,4-di-tert-butylphenyl)pentaerythritol diphosphite and tetrakis(2,4-di-tert-butylphenyl) 4,4'-biphenylenediphosphite.
Examples of sulfur-comprising antioxidants are dilauryl thiodipropionate, dimyristyl thiodipropionate, distearyl thiodipropionate, pentaerythritol tetrakis(a-laurylthiopropionate) and pentaerythritol tetrakis-((3-hexylthiopropionate).
Other antioxidants and light stabilizers which can be used together with the formulations according to the invention are, for example, 2-(2'-hydroxyphenyl)-benzotriazoles, 2-hydroxybenzophenones, aryl esters of hydroxybenzoic acids, a-cyanocinnamic acid derivatives, benzimidazolecarboxanilides, nickel compounds or oxalanilides.
Particularly good stabilization is achieved when at feast one light stabilizer from the compound class of sterically hindered amines is also added in the usual concentration to the formulations according to the invention.
Examples of suitable sterically hindered amines are: bas(2,2,6,6-tetramethylpiperidyl) sebacate, bas(1,2,2,6,6-pentamethylpiperidyl) sebacate, the condensation product of 1-hydroxyethyl-2,2,6,6-tetramethyl-4-hydroxypiperidine and succinic acid, the condensation product of N,N'-di(2,2,6,6-tetramethylpiperidyl)hexamethylenediamine and 4-tert-octylamino-2,6-dichloro-1,3,5-triazine, tris(2,2,6,6-tetramethylpiperidyl) nitrilotriacetate, tetrakis(2,2,6,6-tetramethyl-4-piperidyl) 1,2,3,4-butanetetracarboxylate, 1,1'-(1,2-ethanediyl)-bas(3,3,5,5-tetramethylpiperazinone), the condensation products of 4-amino-2,2,6,6-tetramethylpiperidines and tetramethylolacetylenediureas.
Examples of plastics which can be stabilized by the compounds I according to the invention and may be mentioned are:
polymers of mono- and diolefins, such as, for example, low density or high density polyethylene, polypropylene, linear poly-1-butene, polyisoprene, polybutadiene, and copolymers of mono- or diolefins or mixtures of said polymers;
copolymers of mono- or diofefins with other vinyl monomers, such as, for example, ethylene/alkyl acrylate copolymers, ethylene/alkyl methacrylate copolymers, ethylene/vinyl acetate copolymers or ethylene/acrylic acid copolymers;
polystyrene and copolymers of styrene or -a-methylstyrene with dienes and/or acrylic derivatives, such as, for example, styrene/butadiene, styrene/acrylonitrile (SAN), styrene/ethyl methacrylate, styrene/butadiene/ethyl acrylate, styrene/acryfonitrilelmethacrylate, acrylonitrile/butadienelstyrene (ABS) or methyl methacrylate/butadiene/styrene (MBS);
halogen-containing polymers, such as, for example, polyvinyl chloride, polyvinyl fluoride, polyvinylidene fluoride and copolymers thereof;
polymers derived fram a,f3-unsaturated acids and derivatives thereof, such as polyacrylates, polymethacrylates, polyacrylamides and polyacrylonitriles;
polymers derived from unsaturated alcohols and amines or acyl derivatives or acetals 5 thereof, e.g. polyvinyl alcohol and polyvinyl acetate;
polyurethanes, polyamides, polyureas, polyesters, polycarbonates, polysulfonates, polyether sulfones and polyether ketones.
10 Furthermore, the formulations according to the invention can be used to stabilize aqueous emulsion paints and surface coatings, e.g. industrial finishes. Of these, particular attention is drawn to baking finishes, and, in turn, of these, automotive finishes, preferably two-coat finishes.
The formulations can be added in solid or liquid form to the surface coating.
Their good solubility in surface coating systems is of particular advantage here.
Even in the case of the use as stabilizers in surface coatings, it is possible also to use the additional additives already listed, in particular antioxidants and light stabilizers.
The photoprotective agent formulations according to the invention are also very particularly preferably suitable as photostable UV filters in cosmetic and dermatological preparations for protecting human skin or human hair from solar rays and also from artificial light which has high UV contents, alone or together with compounds which absorb in the UV region and are known for cosmetic or pharmaceutical preparations.
Thus, in the widest sense, the term organic materials also means human skin and human hair. The cosmetic and pharmaceutical preparations as such are of course also stabilized at the same time in order to remain effective for as long as possible.
Accordingly, the present invention also relates to cosmetic and pharmaceutical preparations comprising photoprotective agents for protecting human skin or human hair from UV light in the range from 280 to 400 nm, which comprise, as photostable UV
filters and in a cosmetically or pharmaceutically suitable carrier, effective amounts of a formulation of the triazine I in amorphous or partially amorphous form - alone or together with compounds which absorb in the UV-A and UV-B region and are known per se for cosmetic and pharmaceutical preparations - the formulations being aqueous dispersions according to the invention mentioned in the introduction or the dry powders prepared therefrom.
The amount of triazine I in the form of the formulations according to the invention which is used in the cosmetic and pharmaceutical preparations is in the range from 0.05 to 20% by weight, preferably 0.1 to 10% by weight, particularly preferably in the range from 1 to 7°1° by weight, based on the total amount of the cosmetic and pharmaceutical preparation.
The cosmetic and pharmaceutical preparations comprising photoprotective agents are generally based on a carrier which comprises at least one oil phase.
Preparations based solely on aqueous components are, however, also possible. Accordingly, suitable preparations are oils, oil-in-water and water-in-oil emulsions, creams and pastes, lip-protection stick compositions or grease-free gels.
Suitable emulsions are inter alia also ONV macroemulsions, O/W microemulsions or O1V11/O emulsions containing triazine of the formula I present in dispersed form, the emulsions being obtainable by phase inversion technology, as in DE-A-197 26 121.
Customary cosmetic auxiliaries which may be suitable as additives are, for example, coemulsifiers, fats and waxes, stabilizers, thickeners, biogenic active ingredients, film formers, fragrances, dyes, pearlizing agents, preservatives, pigments, electrolytes (e.g.
magnesium sulfate) and pH regulators. Suitable coemulsifiers are, preferably, known W/O and also O/1N emulsifiers, such as, for example, polyglycerol esters, sorbitan esters or partially esterified glycerides. Typical examples of fats are glycerides; waxes which may be mentioned are inter alia beeswax, paraffin wax or microcrystalline waxes, if appropriate in combination with hydrophilic waxes. Stabilizers which may be used are metal salts of fatty acids, such as, for example, magnesium, aluminum and/or zinc stearate. Examples of suitable thickeners are crosslinked polyacrylic acids and derivatives thereof, polysaccharides, in particular xanthan gum, guar guar, agar agar, alginates and tyloses, carboxymethylcellulose and hydroxyethylcellulose, and also fatty alcohols, monoglycerides and fatty acids, polycrylates, polyvinyl alcohol and polyvinylpyrrolidone. The term biogenic active ingredients means, for example, plant extracts, protein hydrolyzates and vitamin complexes. Customary film formers are, for example, hydrocolloids, such as chitosan, microcrystalline chitosan or quaternary chitosan, polyvinylpyrrolidone, vinylpyrrolidone/vinyl acetate copolymers, polymers of the acrylic acid series, quaternary cellulose derivatives and similar compounds.
Examples of suitable preservatives are formaldehyde solution, p-hydroxybenzoate or sorbic acid. Examples of suitable pearlizing agents are glycol distearic esters, such as ethylene glycol distearate, but also fatty acids and fatty acid monoglycol esters. Dyes which may be used are the substances suitable and approved for cosmetic purposes, as listed, for example, in the publication "Kosmetische Farbemittel" [Cosmetic Colorants] from the Farbstoffkommission der Deutschen Forschungsgemeinschaft [Dyes Commission of the German Research Council], published by Verlag Chemie, Weinheim, 1984. These dyes are usually used in a concentration of from 0.001 to 0.1 by weight, based on the total mixture.
An additional content of antioxidants is generally preferred. Thus, favorable antioxidants which can be used ace all antioxidants which are suitable or customary for cosmetic and/or dermatological applications.
The antioxidants are advantageously chosen from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and derivatives thereof, imidazoles (e.g.
urocanic acid) and derivatives thereof, peptides such as D,L-carnosine, D-carnosine, L-carnosine and derivatives thereof (e.g. anserine), carotenoids, carotene (e.g. (3-carotene, lycopene) and derivatives thereof, chlorogenic acid and derivatives thereof, lipoic acid and derivatives thereof (e.g. dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (e.g. thiorodoxin, glutathione, cysteine, cystine, cystamine and the glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, y-linoleyl, cholesteryl and glyceryl esters thereof) and salts thereof, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (e.g. buthionine sulfoximines, homocysteine sulfoximines, buthionine sulfones, yenta-, hexa-, heptathionine sulfoximine) in very low tolerated doses (e.g. pmol to Nmollkg), also (metal) cheiating agents (e.g. a-hydroxyfatty acids, palmitic acid, phytic acid, lactoferrin), a-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA and derivatives thereof, unsaturated fatty acids and derivatives thereof (e.g. y-linolenic acid, linoleic acid, oleic acid), folic acid and derivatives thereof, ubiquinone and ubiquinol and derivatives thereof, vitamin C and derivatives thereof (e.g. ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherol and derivatives (e.g.
vitamin E
acetate, tocotrienol}, vitamin A and derivatives (vitamin A palmitate) and coniferyl benzoate of benzoin resin, rutic acid and derivatives thereof, a-glycosyfrutin, ferulic acid, furfurylideneglucitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiac resin acid, nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and derivatives thereof, mannose and derivatives thereof, zinc and derivatives thereof (e.g. ZnO, ZnS04), selenium and derivatives thereof (e.g.
selenomethionine), stilbenes and derivatives thereof (e.g. stilbene oxide, trans-stilbene oxide}.
The amount of the abovementioned antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.05 to 20°t°
by weight, in particular 1 to 10% by weight, based on the total weight of the preparation.
If vitamin E and/or derivatives thereof are the antioxidant or antioxidants, it is advantageous to choose the respective concentration thereof from the range 0.001 to 10% by weight, based on the total weight of the formulation.
If vitamin A and/or derivatives thereof or carotenoids are the antioxidant or antioxidants, it is advantageous to choose the respective concentration thereof from the range 0.001 to 10% by weight, based on the total weight of the formulation.
Customary oil components in cosmetics are, for example, silicone oils, paraffin oil, glyceryl stearate, isopropyl myristate, diisopropyl adipate, cetylstearyl 2-ethylhexanoate, hydrogenated polyisobutene, vaseline, capryliclcapric triglycerides, microcrystalline wax, lanolin and stearic acid.
The total proportion of auxiliaries and additives can be 1 to 80% by weight, preferably 6 to 40% by weight, and the nonaqueous proportion ("active substance") can be 20 to 80% by weight, preferably 30 to 70% by weight, based on the compositions. The compositions can be prepared in a manner known per se, i.e. for example by hot, cold, hot-hotlcold or PIT emulsification. This is a purely mechanical process, and no chemical reaction takes place.
Such sunscreen preparations can accordingly be in liquid, paste or solid form, for example as water-in-oil creams, oil-in-Water creams and lotions, aerosol foam creams, gels, oils, marking pencils, powders, sprays or alcohol-aqueous lotions.
Finally, it is possible additionally to use further substances known per se which absorb in the UV region, provided they are stable in the overall system of the combination of UV filters to be used according to the invention.
The majority of photoprotective agents in the cosmetic and pharmaceutical preparations used to protect the human epidermis consists of compounds which absorb UV fight in the UV-B region, i.e. in the range from 280 to 320 nm. For example, the proportion of the UV-A absorbers to be used according to the invention is 10 to 90% by weight, preferably 20 to 50% by weight, based on the total amount of UV-B and UV-A absorbing substances.
Suitable UV filter substances which are used in combination with the formulations to be used according to the invention are any UV-A and UV-B filter substances.
Examples which may be mentioned are:
No Substance CAS No.(=acid) 1 4-Aminobenzoic acid 150-13-0 2 3-(4'-Trimethylammonium)benzylidenebornan-2-one52793-97-2 I methylsulfate 3 3,3,5-Trimethylcyclohexyl salicylate(homosalate)118-56-9 4 2-Hydroxy-4-methoxybenzophenone(oxybenzone) 131-57-7 5 2-Phenylbenzimidazole-5-sulfonic acid and 27503-81-7 its potassium, sodium and triethanolamine salts 6 3,3'-(1,4-Phenylenedimethine}-bis(7,7-dimethyl-2-90457-82-2 oxobicyclo[2.2.1]heptane-1-methanesulfonic acid) and its salts 7 Polyethoxyethyl4-bis(polyethoxy)aminobenzoate113010-52-9 8 2-Ethylhexyl4-dimethylaminobenzoate 21245-02-3 9 2-Ethylhexyl salicylate 118-60-5 10 2-Isoamyl4-methoxycinnamate 71617-10-2 11 2-Ethylhexyl 4-methoxycinnamate 5466-77-3 12 2-Hydroxy-4-methoxybenzophenone-5-sulfonic 4065-45-6 acid (sulisobenzone) and the sodium salt 13 3-(4'-Sulfobenzylidene)bornan-2-one and salts58030-58-6 14 3-Benzylidenebornan-2-one 16087-24-8 15 1-(4'-Isopropylphenyl~--3-phenylpropane-1,3--dione63260-25-9 16 4-Isopropylbenzyl salicylate 94134-93-7 17 3-Imidazol--~-ylacrylic acid and its ethyl ~ 104-98-3 ester 18 Ethyl2-cyano-3,3-diphenylacrylate 5232-99-5 19 2'-Ethylhexyl2-cyano-3,3-~iiphenylacrylate 6197-30-4 20 Menthyl o-aminobenzoate or:5-methyl-2-(1-methylethyl}-2-134-09-8 aminobenzoate 21 Glyceryl p-aminobenzoate or:1-glyceryl 4-aminobenzoate136-44-7 22 2,2'-Dihydroxy-4-methoxybenzophenone (dioxybenzone)131-53-3 23 2-Hydroxy-d-methoxy-4-methylbenzophenone (mexenone)1641-17-4 24 Triethanolamine salicylate 2174-16-5 25 Dimethoxyphenylglyoxalic acid or sodium 3,4- 4732-70-1 dimethoxyphenylglyoxalate 26 3-(4'-Sulfobenzylidene)bornan-2-one and its 56039-58-8 salts 27 4-tert-Butyi-4'-methoxydibenzoylmethane 70356-09-1 28 2,2',4,4'-Tetrahydroxybenzophenone 131-55-5 29 2,2'-Methylenebis[6(2H-benzotriazol-2-y1~4-(1,1,3,3-103597-45-1 tetramethylbutyl)phenolJ
30 2,2'-(1,4-Phenylene)-bis-1 H-benzimidazofe-4,6-disulfonic180898-37-7 acid, Na salt 31 2,4-bis(4-(2-Ethylhexyloxy}-2-hydroxy]phenyl-6-(4-187393-00-6 methoxyphenyl~-(1,3,5--triazine 32 3-(4-Methylbenzylidene)camphor 36861-47-9 33 Polyethoxyethyl4-bis(polyethoxy)paraaminobenzoate113010-52-9 34 2,4-Dihydroxybenzophenone 131-56-6 35 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone-5,5'-disodium3121-60-6 sulfonate Polymeric or polymer-bonded filter substances can also be used according to the invention.
The cosmetic and dermatological preparations according to the invention can additionally advantageously comprise inorganic pigments based on metal oxides andlor other metal compounds which are insoluble or sparingly soluble in water, for example the oxides of titanium (Ti02), zinc (Zn0), iron (e.g. Fe203), zirconium (Zr02), silicon (Si02), manganese (e.g. Mn0), aluminum (A1203), cerium (e.g. Ce203), mixed oxides of the corresponding metals, and mixtures of such oxides. Particular preference is given to pigments based on Ti02 and ZnO.
The inorganic pigments may be present here in hydrophobic form, i.e. surface-treated to repel water. This surface treatment may involve providing the pigments with a thin hydrophobic layer by a method known per se, as described in DE-A-33 14 742.
To protect human hair from UV rays, the photoprotective agent formulations according to the invention can be incorporated into shampoos, lotions, gels, hairsprays, hair colorants, aerosol foam creams or emulsions in concentrations of from 0.1 to 10% by weight, preferably 1 to 7% by weight. The respective formulations can inter alia be used for washing, coloring and for styling hair.
The formulations to be used according to the invention are usually notable for a particularly high absorbance in the UV-A radiation region with a sharp band structure.
Moreover, they are readily soluble in cosmetic oils and can easily be incorporated into cosmetic formulations. The emulsions prepared with the formulations are particularly 5 notable for their high stability, the formulations I themselves are notable for their high photostability, and the preparations prepared therewith are notable for their pleasant feel on the skin.
The UV fitter action of the formulations according to the invention can also be utilized 10 for stabilizing active ingredients and auxiliaries in cosmetic and pharmaceutical formulations.
The preparations according to the invention are notable for particularly high absorbance in the UV-B radiation region with a sharp band structure and high light 15 protection factors.
In particular, the high sun protection factor of the preparations which was measured even at low concentrations of triazine compound I was surprising.
In addition, the preparations according to the invention have the advantage over other triazine-containing formulations of improved dispersibility in cold water.
The examples below serve to illustrate the present invention without limiting it.
Example 1 Preparation of a Uvinul~ T150-containing dry powder having an active ingredient content of 20% by weight a) Preparation of the aqueous dispersion A molecularly disperse solution of 5 g of Uvinul~ T150 in 95 g of acetone was passed at 150°C to a mixing chamber, where it was mixed with 1300 g of a 30°C
hot aqueous solution of HiCap~ (15 g!1). The entire process was carried out with a pressure limit of 40 bar in order to prevent evaporation of the solvent.
After mixing, a colloidally disperse Uvinul~ T150 dispersion with a white cloudy color was obtained.
Fraunhofer diffraction was used to determine the average volume distribution as D (4.3) = 0.50 ~m with a fines content of the distribution of 98.5% < 1.22 pm.
b) Preparation of a Uvinul~ T150-containing aqueous dry powder Spray-drying the dispersion resulted in a dry powder having an active ingredient content of 20.56% by weight of Uvinul~ T150 (content determination by means of UV/VIS spectroscopy). The dry powder could be redispersed in demineralized water again to form a white cloudy dispersion (hydrosol).
Fraunhofer diffraction was used to determine the average volume distribution in the redispersion as D (4.3) = 0.65 pm with a fines content of the distribution of 97.1 °l° < 1.22 pm.
Example 2 Preparation of a Uvinul~ T150-containing dry powder having an active ingredient content of 20% by weight a) Preparation of the aqueous dispersion A molecularly disperse solution of 10 g of Uvinul~ T150 in 90 g of isopropanol/water (9:1, vlv) was passed at 150°C to a mixing chamber, where it was mixed with 1000 g of a 30°C hot aqueous solution of HiCap~ (30 g/1). The entire process was carried out with a pressure limit of 40 bar in order to prevent evaporation of the solvent. After mixing, a colloidally disperse Uvinul~ T150 dispersion with a white cloudy color was obtained.
Fraunhofer diffraction was used to determine the average volume distribution as D (4.3) = 0.50 ~m with a fines content of the distribution of 98.5% < 1.22 Vim.
b) Preparation of a Uvinul~ T150-containing aqueous dry powder Spray-drying the dispersion resulted in a dry powder having an active ingredient content of 20.56% by weight of Uvinul~ T150 (content determination by means of UVNIS spectroscopy). The dry powder could be redispersed in demineralized water again to form a white cloudy dispersion (hydrosol).
Fraunhofer diffraction was used to determine the average volume distribution in the redispersion as D (4.3) = 0.65 ~m with a fines content of the distribution of 97.1 % < 1.22 pm.
Example 3 Preparation of a Uvinul~ T150-containing dry powder having an active ingredient content of 15°!° by weight a) Preparation of the aqueous dispersion 25 g of Uvinul~ T150 were dissolved in 216 g of isopropanol at room temperature to give a molecularly disperse solution. To precipitate out the Uvinul~ T150 in colloidally disperse form, the solution was passed at 240°C to a mixing chamber, where it was mixed with an aqueous solution of 45 g of HiCap in 1455 ml of demineralized water. The entire process was carried out with a pressure limit of 40 bar in order to prevent evaporation of the solvent. After mixing, a colloidally disperse Uvinul~ T150 dispersion with a white cloudy color was obtained.
Fraunhofer diffraction was used to determine the average volume distribution as D (4.3) = 0.52 Nm with a fines content of the distribution of 98.5% < 1.22 Nm.
b) Preparation of a Uvinul~ T150-containing aqueous dry powder Spray-drying the dispersion resulted in a dry powder having an active ingredient content of 15.86% by weight of Uvinul~ T150 (content determination by means of UVNIS spectroscopy). The dry powder could be redispersed in demineralized water again to form a white cloudy dispersion (hydrosol).
Fraunhofer diffraction was used to determine the average volume distribution in the redispersion as D (4.3) = 1.91 Nm with a fines content of the distribution of 84.67% < 1.22 Nm.
Preparations Example 4: Lip care composition Mass content (% by weight) ad 100 Eucerinum anhydricum 10.00 Glycerol 10.00 Titanium dioxide, micronized 5.00 Uvinul~ T150 dry powder from Example 8.00 Octyl methoxycinnamate 5.00 Zinc oxide 4.00 Castor oil 4.00 Pentaerythritil stearatelcaprate/caprylate adipate 3.00 Glyceryl stearate SE
2.00 Beeswax 2.00 Microcrystafline wax 2.00 Quaternium-18 bentonite 1.50 PEG-.45/dodecyl glycol copolymer Example 5: Composition for sunblock containing micropigments Mass content (% by weight) ad 100 Water 10.00 Octy1 methoxycinnamate 6.00 PEG-7-Hydrogenated castor oil 6.00 Titanium dioxide, micronized 5.00 Uvinul~ T150 dry powder from Example 1 5.00 Mineral oil 5.00 Isoamyl p-methoxycinnamate 5.00 Propylene glycol 3.00 Jojoba oil 3.00 4-Methylbenzylidenecamphor 2.00 PEG-45/dodecyl glycol copolymer 1.00 Dimethicone 0.50 PEG-40 hydrogenated castor oil 0.50 Tocopheryl acetate 0.50 Phenoxyethanol 0.20 EDTA
Example 6: Grease-free gel Mass content (% by weight) ad 100 Water 8.00 Octyl methoxycinnamate 7.00 Titanium dioxide, micronized 5.00 Uvinul~ T150 dry powder from Example 5.00 Glycerol .
5.00 PEG-25 PABA
1.00 4-Methylbenzylidenecamphor 0.40 Acrylates C,o-C3o alkyl acrylate crosspolymer 0.30 Imidazolidinylurea 0.25 Hydroxyethylcellulose 0.25 Sodium methylparaben 0.20 Disodium EDTA
0.15 Fragrance 0.15 Sodium propylparaben 0.10 Sodium hydroxide Example 7: Suncream (SPF 20) Mass content (% by weight) ad 100 Water 8.00 Octyf methoxycinnamate 8.00 Titanium dioxide, micronized 6.00 PEG-7-Hydrogenated castor oil 5.00 Uvinul~ T150 dry powder from Example 1 6.00 Mineral oil 5.00 Isopropyl palmitate 0.30 Imidazolidinylurea 3.00 Jojoba oil 2.00 PEG-45/Dodecyl glycol copolymer 1.00 4-Methylbenzylidenecamphor 0.60 Magnesium stearate 0.50 Tocopheryl acetate 0.25 Methylparaben 0.20 Disodium EDTA
0.15 Propylparaben Example 8: Water-resistant suncream Mass content (% by weight) ad 100 Water 8.00 Octyl methoxycinnamate 5.00 PEG-7-Hydrogenated castor oil 5.00 Propylene glycol 4.00 Isopropyl palmitate 4.00 Caprylic/capric triglyceride 5.00 Uvinul~ T150 dry powder from Example 1 4.00 Glycerol 3.00 Jojoba oil 2.00 4-Methylbenzylidenecamphor 2.00 Titanium dioxide, micronized 1.50 PEG-45/dodecyl glycol copolymer 1.50 Dimethicone 0.70 Magnesium sulfate 0.50 Magnesium stearate 0.15 Fragrance Example 9: Sun milk (SPF 6) 5 Mass content (% by weight) ad 100 Water 10.00 Mineral oil 6.00 PEG-7-Hydrogenated castor oil 10 5.00 Isopropyl palmitate 3.50 Octyl methoxycinnamate 5.00 Uvinul~ T150 dry powder from Example 1 3.00 Caprylic/capric triglyceride 3.00 Jojoba oil 15 2.00 PEG-45ldodecyl glycol copolymer 0.70 Magnesium sulfate 0.60 Magnesium stearate 0.50 Tocopheryl acetate 3.00 Glycerol 20 0.25 Methylparaben 0.15 Propylparaben 0.05 Tocopherol Example 10: Day lotion with UV protection Mass content (°!° by weight) ad 100 Water 2.00 Cetearyl alcohol 1.00 Glycerol monostearate 2.00 Vaseline 7.50 Octyl methoxycinnamate 4.00 Octyl salicylate 3.00 Uvinul~ T150 dry powder from Example 1 1.50 4-tert-Butyl-4'-methoxydibenzoylmethane 0.50 Dimethicone 5.00 Propylene glycol 0.20 EDTA
0.20 Carbomer 5.00 C,z--C,5 Alkyl benzoate 0.27 Triethanolamine 1.00 Tocopheryl acetate q.s. Fragrance Example 11: Day cream with UV protection Mass content (% by weight}
ad 100 Water 2.00 Cetearyl alcohol 2.00 Cetyl alcohol 1.00 Glycerol monostearate 2.00 Vaseline 7.50 Octyl methoxycinnamate 4.00 Octyl salicylate 3.00 Uvinul~ T150 dry powder from Example 1 1.50 4-tert-Butyf-4'-methoxydibenzoylmethane 4.00 Propylene glycol 0.20 EDTA
0.20 Carbomer 0.20 Xanthan 0.20 C,o-C3o Alkyl acrylate crosspolymer 5.00 C,2-C,5 Alkyl benzoate 0.54 Triethanolamine 1.00 Tocopheryl acetate q.s. Fragrance q.s. Preservative Example 12: Liquid make up Mass content (% by weight) ad 100 Water 2.00 Cetearyl alcohol 2.00 Ceteareth 25 6.00 Glycerol monostearate 1.00 Cetyl alcohol 8.00 Paraffin oil 7.00 Cetearyl octanoate 0.2 Dimethicone 3.00 Propylene glycol 1.00 Panthenol 3.00 Uvinul~ T150 dry powder from Example 1 1.50 4-tent-Butyl-4'-methoxydibenzoylmethane 3.50 Octyl methoxycinnamate 0.1 Bisabolol 5.70 Titanium dioxide 1.10 Iron oxide q.s. Fragrance Example 13: Hair gel with sun protection Mass content (°l° by weight) ad 100 Water 1.20 Carbomer 0.50 Hydroxyethylcellulose 4.00 Triethanolamine 0.70 PEG-40 Hydrogenated castor oil 1.50 Uvinul~ T150 dry powder from Example 1 0.70 4-tert-Butyl-4'-methoxydibenzoylmethane 2.80 Octyl methoxycinnamate 5.00 Propylene glycol 0.01 EDTA
q.s. Fragrance q.s. Sicovit Patent Blue 85 E 131
The cosmetic and dermatological preparations according to the invention can additionally advantageously comprise inorganic pigments based on metal oxides andlor other metal compounds which are insoluble or sparingly soluble in water, for example the oxides of titanium (Ti02), zinc (Zn0), iron (e.g. Fe203), zirconium (Zr02), silicon (Si02), manganese (e.g. Mn0), aluminum (A1203), cerium (e.g. Ce203), mixed oxides of the corresponding metals, and mixtures of such oxides. Particular preference is given to pigments based on Ti02 and ZnO.
The inorganic pigments may be present here in hydrophobic form, i.e. surface-treated to repel water. This surface treatment may involve providing the pigments with a thin hydrophobic layer by a method known per se, as described in DE-A-33 14 742.
To protect human hair from UV rays, the photoprotective agent formulations according to the invention can be incorporated into shampoos, lotions, gels, hairsprays, hair colorants, aerosol foam creams or emulsions in concentrations of from 0.1 to 10% by weight, preferably 1 to 7% by weight. The respective formulations can inter alia be used for washing, coloring and for styling hair.
The formulations to be used according to the invention are usually notable for a particularly high absorbance in the UV-A radiation region with a sharp band structure.
Moreover, they are readily soluble in cosmetic oils and can easily be incorporated into cosmetic formulations. The emulsions prepared with the formulations are particularly 5 notable for their high stability, the formulations I themselves are notable for their high photostability, and the preparations prepared therewith are notable for their pleasant feel on the skin.
The UV fitter action of the formulations according to the invention can also be utilized 10 for stabilizing active ingredients and auxiliaries in cosmetic and pharmaceutical formulations.
The preparations according to the invention are notable for particularly high absorbance in the UV-B radiation region with a sharp band structure and high light 15 protection factors.
In particular, the high sun protection factor of the preparations which was measured even at low concentrations of triazine compound I was surprising.
In addition, the preparations according to the invention have the advantage over other triazine-containing formulations of improved dispersibility in cold water.
The examples below serve to illustrate the present invention without limiting it.
Example 1 Preparation of a Uvinul~ T150-containing dry powder having an active ingredient content of 20% by weight a) Preparation of the aqueous dispersion A molecularly disperse solution of 5 g of Uvinul~ T150 in 95 g of acetone was passed at 150°C to a mixing chamber, where it was mixed with 1300 g of a 30°C
hot aqueous solution of HiCap~ (15 g!1). The entire process was carried out with a pressure limit of 40 bar in order to prevent evaporation of the solvent.
After mixing, a colloidally disperse Uvinul~ T150 dispersion with a white cloudy color was obtained.
Fraunhofer diffraction was used to determine the average volume distribution as D (4.3) = 0.50 ~m with a fines content of the distribution of 98.5% < 1.22 pm.
b) Preparation of a Uvinul~ T150-containing aqueous dry powder Spray-drying the dispersion resulted in a dry powder having an active ingredient content of 20.56% by weight of Uvinul~ T150 (content determination by means of UV/VIS spectroscopy). The dry powder could be redispersed in demineralized water again to form a white cloudy dispersion (hydrosol).
Fraunhofer diffraction was used to determine the average volume distribution in the redispersion as D (4.3) = 0.65 pm with a fines content of the distribution of 97.1 °l° < 1.22 pm.
Example 2 Preparation of a Uvinul~ T150-containing dry powder having an active ingredient content of 20% by weight a) Preparation of the aqueous dispersion A molecularly disperse solution of 10 g of Uvinul~ T150 in 90 g of isopropanol/water (9:1, vlv) was passed at 150°C to a mixing chamber, where it was mixed with 1000 g of a 30°C hot aqueous solution of HiCap~ (30 g/1). The entire process was carried out with a pressure limit of 40 bar in order to prevent evaporation of the solvent. After mixing, a colloidally disperse Uvinul~ T150 dispersion with a white cloudy color was obtained.
Fraunhofer diffraction was used to determine the average volume distribution as D (4.3) = 0.50 ~m with a fines content of the distribution of 98.5% < 1.22 Vim.
b) Preparation of a Uvinul~ T150-containing aqueous dry powder Spray-drying the dispersion resulted in a dry powder having an active ingredient content of 20.56% by weight of Uvinul~ T150 (content determination by means of UVNIS spectroscopy). The dry powder could be redispersed in demineralized water again to form a white cloudy dispersion (hydrosol).
Fraunhofer diffraction was used to determine the average volume distribution in the redispersion as D (4.3) = 0.65 ~m with a fines content of the distribution of 97.1 % < 1.22 pm.
Example 3 Preparation of a Uvinul~ T150-containing dry powder having an active ingredient content of 15°!° by weight a) Preparation of the aqueous dispersion 25 g of Uvinul~ T150 were dissolved in 216 g of isopropanol at room temperature to give a molecularly disperse solution. To precipitate out the Uvinul~ T150 in colloidally disperse form, the solution was passed at 240°C to a mixing chamber, where it was mixed with an aqueous solution of 45 g of HiCap in 1455 ml of demineralized water. The entire process was carried out with a pressure limit of 40 bar in order to prevent evaporation of the solvent. After mixing, a colloidally disperse Uvinul~ T150 dispersion with a white cloudy color was obtained.
Fraunhofer diffraction was used to determine the average volume distribution as D (4.3) = 0.52 Nm with a fines content of the distribution of 98.5% < 1.22 Nm.
b) Preparation of a Uvinul~ T150-containing aqueous dry powder Spray-drying the dispersion resulted in a dry powder having an active ingredient content of 15.86% by weight of Uvinul~ T150 (content determination by means of UVNIS spectroscopy). The dry powder could be redispersed in demineralized water again to form a white cloudy dispersion (hydrosol).
Fraunhofer diffraction was used to determine the average volume distribution in the redispersion as D (4.3) = 1.91 Nm with a fines content of the distribution of 84.67% < 1.22 Nm.
Preparations Example 4: Lip care composition Mass content (% by weight) ad 100 Eucerinum anhydricum 10.00 Glycerol 10.00 Titanium dioxide, micronized 5.00 Uvinul~ T150 dry powder from Example 8.00 Octyl methoxycinnamate 5.00 Zinc oxide 4.00 Castor oil 4.00 Pentaerythritil stearatelcaprate/caprylate adipate 3.00 Glyceryl stearate SE
2.00 Beeswax 2.00 Microcrystafline wax 2.00 Quaternium-18 bentonite 1.50 PEG-.45/dodecyl glycol copolymer Example 5: Composition for sunblock containing micropigments Mass content (% by weight) ad 100 Water 10.00 Octy1 methoxycinnamate 6.00 PEG-7-Hydrogenated castor oil 6.00 Titanium dioxide, micronized 5.00 Uvinul~ T150 dry powder from Example 1 5.00 Mineral oil 5.00 Isoamyl p-methoxycinnamate 5.00 Propylene glycol 3.00 Jojoba oil 3.00 4-Methylbenzylidenecamphor 2.00 PEG-45/dodecyl glycol copolymer 1.00 Dimethicone 0.50 PEG-40 hydrogenated castor oil 0.50 Tocopheryl acetate 0.50 Phenoxyethanol 0.20 EDTA
Example 6: Grease-free gel Mass content (% by weight) ad 100 Water 8.00 Octyl methoxycinnamate 7.00 Titanium dioxide, micronized 5.00 Uvinul~ T150 dry powder from Example 5.00 Glycerol .
5.00 PEG-25 PABA
1.00 4-Methylbenzylidenecamphor 0.40 Acrylates C,o-C3o alkyl acrylate crosspolymer 0.30 Imidazolidinylurea 0.25 Hydroxyethylcellulose 0.25 Sodium methylparaben 0.20 Disodium EDTA
0.15 Fragrance 0.15 Sodium propylparaben 0.10 Sodium hydroxide Example 7: Suncream (SPF 20) Mass content (% by weight) ad 100 Water 8.00 Octyf methoxycinnamate 8.00 Titanium dioxide, micronized 6.00 PEG-7-Hydrogenated castor oil 5.00 Uvinul~ T150 dry powder from Example 1 6.00 Mineral oil 5.00 Isopropyl palmitate 0.30 Imidazolidinylurea 3.00 Jojoba oil 2.00 PEG-45/Dodecyl glycol copolymer 1.00 4-Methylbenzylidenecamphor 0.60 Magnesium stearate 0.50 Tocopheryl acetate 0.25 Methylparaben 0.20 Disodium EDTA
0.15 Propylparaben Example 8: Water-resistant suncream Mass content (% by weight) ad 100 Water 8.00 Octyl methoxycinnamate 5.00 PEG-7-Hydrogenated castor oil 5.00 Propylene glycol 4.00 Isopropyl palmitate 4.00 Caprylic/capric triglyceride 5.00 Uvinul~ T150 dry powder from Example 1 4.00 Glycerol 3.00 Jojoba oil 2.00 4-Methylbenzylidenecamphor 2.00 Titanium dioxide, micronized 1.50 PEG-45/dodecyl glycol copolymer 1.50 Dimethicone 0.70 Magnesium sulfate 0.50 Magnesium stearate 0.15 Fragrance Example 9: Sun milk (SPF 6) 5 Mass content (% by weight) ad 100 Water 10.00 Mineral oil 6.00 PEG-7-Hydrogenated castor oil 10 5.00 Isopropyl palmitate 3.50 Octyl methoxycinnamate 5.00 Uvinul~ T150 dry powder from Example 1 3.00 Caprylic/capric triglyceride 3.00 Jojoba oil 15 2.00 PEG-45ldodecyl glycol copolymer 0.70 Magnesium sulfate 0.60 Magnesium stearate 0.50 Tocopheryl acetate 3.00 Glycerol 20 0.25 Methylparaben 0.15 Propylparaben 0.05 Tocopherol Example 10: Day lotion with UV protection Mass content (°!° by weight) ad 100 Water 2.00 Cetearyl alcohol 1.00 Glycerol monostearate 2.00 Vaseline 7.50 Octyl methoxycinnamate 4.00 Octyl salicylate 3.00 Uvinul~ T150 dry powder from Example 1 1.50 4-tert-Butyl-4'-methoxydibenzoylmethane 0.50 Dimethicone 5.00 Propylene glycol 0.20 EDTA
0.20 Carbomer 5.00 C,z--C,5 Alkyl benzoate 0.27 Triethanolamine 1.00 Tocopheryl acetate q.s. Fragrance Example 11: Day cream with UV protection Mass content (% by weight}
ad 100 Water 2.00 Cetearyl alcohol 2.00 Cetyl alcohol 1.00 Glycerol monostearate 2.00 Vaseline 7.50 Octyl methoxycinnamate 4.00 Octyl salicylate 3.00 Uvinul~ T150 dry powder from Example 1 1.50 4-tert-Butyf-4'-methoxydibenzoylmethane 4.00 Propylene glycol 0.20 EDTA
0.20 Carbomer 0.20 Xanthan 0.20 C,o-C3o Alkyl acrylate crosspolymer 5.00 C,2-C,5 Alkyl benzoate 0.54 Triethanolamine 1.00 Tocopheryl acetate q.s. Fragrance q.s. Preservative Example 12: Liquid make up Mass content (% by weight) ad 100 Water 2.00 Cetearyl alcohol 2.00 Ceteareth 25 6.00 Glycerol monostearate 1.00 Cetyl alcohol 8.00 Paraffin oil 7.00 Cetearyl octanoate 0.2 Dimethicone 3.00 Propylene glycol 1.00 Panthenol 3.00 Uvinul~ T150 dry powder from Example 1 1.50 4-tent-Butyl-4'-methoxydibenzoylmethane 3.50 Octyl methoxycinnamate 0.1 Bisabolol 5.70 Titanium dioxide 1.10 Iron oxide q.s. Fragrance Example 13: Hair gel with sun protection Mass content (°l° by weight) ad 100 Water 1.20 Carbomer 0.50 Hydroxyethylcellulose 4.00 Triethanolamine 0.70 PEG-40 Hydrogenated castor oil 1.50 Uvinul~ T150 dry powder from Example 1 0.70 4-tert-Butyl-4'-methoxydibenzoylmethane 2.80 Octyl methoxycinnamate 5.00 Propylene glycol 0.01 EDTA
q.s. Fragrance q.s. Sicovit Patent Blue 85 E 131
Claims (11)
1. A method of producing a powdered preparation comprising 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)-1,3,5-triazine of the formula I
by a) dispersing the triazine I in an aqueous molecularly disperse or colloidally disperse solution of a protective colloid and b) converting the dispersion obtained into a dry powder by removing the water and, if appropriate, additionally used solvents, and drying, wherein the protective colloid used in process step a) is modified starch.
by a) dispersing the triazine I in an aqueous molecularly disperse or colloidally disperse solution of a protective colloid and b) converting the dispersion obtained into a dry powder by removing the water and, if appropriate, additionally used solvents, and drying, wherein the protective colloid used in process step a) is modified starch.
2. The method according to claim 1, wherein the dispersion in stage a) comprises the following steps:
a1) dissolving the triazine I in one or more water-miscible organic solvent(s) or in a mixture of water and one or more water-miscible organic solvent(s) or a2) dissolving the triazine I in one or more water-immiscible organic solvent(s) and a3) mixing the solution obtained after a1) or a2) with an aqueous molecularly disperse or colloidally disperse solution of modified starch, where the hydrophobic phase of the triazine I is formed as nanodisperse phase.
a1) dissolving the triazine I in one or more water-miscible organic solvent(s) or in a mixture of water and one or more water-miscible organic solvent(s) or a2) dissolving the triazine I in one or more water-immiscible organic solvent(s) and a3) mixing the solution obtained after a1) or a2) with an aqueous molecularly disperse or colloidally disperse solution of modified starch, where the hydrophobic phase of the triazine I is formed as nanodisperse phase.
3. The method according to one of claims 1 or 2, wherein the drying in process step b) is carried out in the presence of a coating material.
4. The method according to one of claims 1 to 3, wherein dispersion step a) is the preparation of a suspension of the triazine I in an aqueous molecularly disperse or colloidally disperse solution of modified starch.
5. The method according to claim 4, wherein the suspension prepared in process step a) is ground before being converted into a dry powder.
6. The method according to claim 4, wherein a1) the triazine I is dissolved in acetone or isopropanol or a mixture of water and acetone or water and isopropanol at temperatures in the range from 50 to 240°C, a3) the solution obtained is mixed with an aqueous molecularly disperse or colloidally disperse solution of modified starch at temperatures in the range from 25 to 120°C and b) the suspension formed is spray-dried after removing the organic solvent.
7. The method according to one of claims 1 to 3, wherein dispersion step a) is the preparation of an emulsion of the triazine I in an aqueous molecularly disperse or colloidally disperse solution of modified starch.
8. The method according to one of claims 1 to 7, wherein the protective colloid used is octenyl succinate starch.
9. A triazine-containing powdered preparation obtainable by a method defined according to one of claims 1 to 8.
10. The preparation according to claim 9 with a content of triazine I of from 0.1 to 70% by weight.
11. The use of the triazine-containing powder defined according to one of claims 9 or 10 as a photostable UV filter in cosmetic and dermatological preparations.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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DE10342856.9 | 2003-09-15 | ||
DE2003142856 DE10342856A1 (en) | 2003-09-15 | 2003-09-15 | Powdered preparations containing 2,4,6-trianilino-p- (carbo-2'-ethylhexyl-1'-oxi) -1,3,5-triazine |
PCT/EP2004/010058 WO2005025530A1 (en) | 2003-09-15 | 2004-09-09 | Powdery preparations containing 2.4.6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxi)-1.3.5-triazine |
Publications (1)
Publication Number | Publication Date |
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CA2536679A1 true CA2536679A1 (en) | 2005-03-24 |
Family
ID=34305817
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA002536679A Abandoned CA2536679A1 (en) | 2003-09-15 | 2004-09-09 | Powdery preparations containing 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxi)-1,3,5-triazine |
Country Status (6)
Country | Link |
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EP (1) | EP1677743A1 (en) |
JP (1) | JP2007505823A (en) |
CN (1) | CN1852698A (en) |
CA (1) | CA2536679A1 (en) |
DE (1) | DE10342856A1 (en) |
WO (1) | WO2005025530A1 (en) |
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BRPI0612705A2 (en) * | 2005-06-29 | 2010-11-30 | Dsm Ip Assets Bv | topical compositions comprising nanoparticles of an isoflavone |
US8182967B2 (en) * | 2009-08-31 | 2012-05-22 | General Electric Company | Optical data storage media and methods for using the same |
FR3053333B1 (en) * | 2016-06-30 | 2018-07-27 | L'oreal | LIQUID MIXTURE CONTAINING 4- (3-ETHOXY-4-HYDROXYPHENYL) BUTAN-2-ONE AND COMBINATION OF NIACINAMIDE, AND COSMETIC COMPOSITION CONTAINING THE SAME |
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US3184385A (en) * | 1961-10-16 | 1965-05-18 | Eastman Kodak Co | Dry, vitamin-active product and process for preparing same |
GB9623026D0 (en) * | 1996-11-06 | 1997-01-08 | Boots Co Ltd | Anhydrous compositions |
FR2772269B1 (en) * | 1997-12-15 | 2000-02-04 | Oreal | COSMETIC AND / OR DERMATOLOGICAL COMPOSITION BASED ON ASCORBIC ACID IN POWDER FORM |
DE50115609D1 (en) * | 2000-02-17 | 2010-10-14 | Basf Se | Aqueous dispersion of water-insoluble organic UV filter substances |
EP1213013B1 (en) * | 2000-11-29 | 2007-04-04 | Basf Aktiengesellschaft | Process for preparing solid compositions of water-soluble, hardly water-soluble or water-insoluble active agents |
-
2003
- 2003-09-15 DE DE2003142856 patent/DE10342856A1/en not_active Withdrawn
-
2004
- 2004-09-09 WO PCT/EP2004/010058 patent/WO2005025530A1/en not_active Application Discontinuation
- 2004-09-09 JP JP2006525764A patent/JP2007505823A/en active Pending
- 2004-09-09 CN CNA2004800265238A patent/CN1852698A/en active Pending
- 2004-09-09 CA CA002536679A patent/CA2536679A1/en not_active Abandoned
- 2004-09-09 EP EP04764994A patent/EP1677743A1/en not_active Withdrawn
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DE10342856A1 (en) | 2005-04-21 |
JP2007505823A (en) | 2007-03-15 |
WO2005025530A1 (en) | 2005-03-24 |
EP1677743A1 (en) | 2006-07-12 |
CN1852698A (en) | 2006-10-25 |
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