CA2536069A1 - Use of green porphyrins in ocular diagnosis and therapy - Google Patents

Use of green porphyrins in ocular diagnosis and therapy Download PDF

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Publication number
CA2536069A1
CA2536069A1 CA002536069A CA2536069A CA2536069A1 CA 2536069 A1 CA2536069 A1 CA 2536069A1 CA 002536069 A CA002536069 A CA 002536069A CA 2536069 A CA2536069 A CA 2536069A CA 2536069 A1 CA2536069 A1 CA 2536069A1
Authority
CA
Canada
Prior art keywords
green
therapy
porphyries
effective
green porphyrins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002536069A
Other languages
French (fr)
Other versions
CA2536069C (en
Inventor
Joan W. Miller
Evangelos S. Gragoudas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Eye and Ear Infirmary
Original Assignee
Massachusetts Eye And Ear Infirmary
Joan W. Miller
Evangelos S. Gragoudas
Massachusetts Eye & Ear Infirmary
Young, Lucy H.Y.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Eye And Ear Infirmary, Joan W. Miller, Evangelos S. Gragoudas, Massachusetts Eye & Ear Infirmary, Young, Lucy H.Y. filed Critical Massachusetts Eye And Ear Infirmary
Publication of CA2536069A1 publication Critical patent/CA2536069A1/en
Application granted granted Critical
Publication of CA2536069C publication Critical patent/CA2536069C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Abstract

Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as macular degeneration, is effective using green porphyries as photoactive agents. Green porphyries are also effective in photodynamic therapy of pigmented tumors of the eye. In addition, green porphyries serve as effective dyes in ocular angiography.
CA002536069A 1994-03-14 1994-03-14 Use of green porphyrins in ocular diagnosis and therapy Expired - Lifetime CA2536069C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1994/002639 WO1995024930A1 (en) 1994-03-14 1994-03-14 Use of green porphyrins in ocular diagnosis and therapy
CA2185644A CA2185644C (en) 1994-03-14 1994-03-14 Use of green porphyrins in ocular diagnosis and therapy

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2185644A Division CA2185644C (en) 1994-03-14 1994-03-14 Use of green porphyrins in ocular diagnosis and therapy

Publications (2)

Publication Number Publication Date
CA2536069A1 true CA2536069A1 (en) 1995-09-21
CA2536069C CA2536069C (en) 2008-06-03

Family

ID=22242340

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002536069A Expired - Lifetime CA2536069C (en) 1994-03-14 1994-03-14 Use of green porphyrins in ocular diagnosis and therapy
CA2185644A Expired - Lifetime CA2185644C (en) 1994-03-14 1994-03-14 Use of green porphyrins in ocular diagnosis and therapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2185644A Expired - Lifetime CA2185644C (en) 1994-03-14 1994-03-14 Use of green porphyrins in ocular diagnosis and therapy

Country Status (3)

Country Link
AU (1) AU6813694A (en)
CA (2) CA2536069C (en)
WO (1) WO1995024930A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1441743A2 (en) * 2001-11-09 2004-08-04 Eyetech Pharmaceuticals Methods for treating ocular neovascular diseases

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770592A (en) * 1991-11-22 1998-06-23 Alcon Laboratories, Inc. Prevention and treatment of ocular neovascularization using angiostatic steroids
JP3845469B2 (en) * 1996-02-21 2006-11-15 明治製菓株式会社 Administration agent for occlusion of neovascularization of the fundus
US5756541A (en) * 1996-03-11 1998-05-26 Qlt Phototherapeutics Inc Vision through photodynamic therapy of the eye
NZ331977A (en) * 1996-03-26 2000-07-28 Pharmacyclics Inc Texaphyrin in photodynamic therapy of pigment-related lesions
US6043237A (en) * 1996-12-10 2000-03-28 Qlt Phototherapeutics, Inc. Use of photodynamic therapy for prevention of secondary cataracts
KR20000057532A (en) * 1996-12-11 2000-09-25 다우 윌리엄스 씨. Use of a texaphyrin in the preparation of a medicament for use in ocular diagnosis and therapy
US6270749B1 (en) 1996-12-11 2001-08-07 Pharmacyclics, Inc. Use of Texaphyrin in ocular diagnosis and therapy
US6022526A (en) * 1997-07-30 2000-02-08 Pharmacyclics, Inc. Use of texaphyrins in detection of melanin and melanin metabolites diagnostic of melanotic melanoma
US6117862A (en) * 1998-10-09 2000-09-12 Qlt, Inc. Model and method for angiogenesis inhibition
IL126953A0 (en) 1998-11-08 1999-09-22 Yeda Res & Dev Pharmaceutical compositions comprising porphyrins and some novel porphyrin derivatives
US6351663B1 (en) 1999-09-10 2002-02-26 Akorn, Inc. Methods for diagnosing and treating conditions associated with abnormal vasculature using fluorescent dye angiography and dye-enhanced photocoagulation
US6944493B2 (en) 1999-09-10 2005-09-13 Akora, Inc. Indocyanine green (ICG) compositions and related methods of use
WO2001017561A1 (en) * 1999-09-10 2001-03-15 Akorn, Inc. Fluorescent dye angiography and dye-enhanced photocoagulation
US6443976B1 (en) * 1999-11-30 2002-09-03 Akorn, Inc. Methods for treating conditions and illnesses associated with abnormal vasculature
EP1267935A2 (en) * 2000-01-12 2003-01-02 Light Sciences Corporation Novel treatment for eye disease
AU2006203034B2 (en) * 2000-02-10 2006-09-07 Massachusetts Eye And Ear Infirmary Methods and compositions for treating conditions of the eye
CA2714081C (en) * 2000-02-10 2013-08-06 Massachusetts Eye And Ear Infirmary Methods and compositions for treating conditions of the eye
US7753943B2 (en) 2001-02-06 2010-07-13 Qlt Inc. Reduced fluence rate PDT
ATE390147T1 (en) * 2001-02-06 2008-04-15 Quadra Logic Tech Inc PHOTODYNAMIC THERAPY WITH REDUCED RADIATION POWER
US6723750B2 (en) 2002-03-15 2004-04-20 Allergan, Inc. Photodynamic therapy for pre-melanomas
AU2003299201A1 (en) 2002-10-03 2004-04-23 Light Sciences Corporation Excitation of photoreactive compounds in eye tissue

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171749A (en) * 1987-01-20 1992-12-15 University Of British Columbia Wavelength-specific cytotoxic agents
US5214036A (en) * 1990-03-08 1993-05-25 University Of British Columbia Benzoporphyrin derivatives for photodynamic therapy

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1441743A2 (en) * 2001-11-09 2004-08-04 Eyetech Pharmaceuticals Methods for treating ocular neovascular diseases
EP1441743A4 (en) * 2001-11-09 2009-02-25 Eyetech Pharmaceuticals Methods for treating ocular neovascular diseases

Also Published As

Publication number Publication date
CA2185644A1 (en) 1995-09-21
CA2185644C (en) 2011-04-12
WO1995024930A1 (en) 1995-09-21
AU6813694A (en) 1995-10-03
CA2536069C (en) 2008-06-03

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Effective date: 20140314