CA2530216C - The use of an edible acid or the potassium or sodium salt thereof in the treatment of allergy - Google Patents

Abstract

The present invention relates to a pharmaceutical composition comprising an edible acid and /or the acidic salt thereof, as well as the use of an edible acid and/or the acidic salt thereof in the manufacture of a pharmaceutical composition for treatment or alleviating immunologically mediated diseases by decreasing the humoral pH value; the invention also relates to the use of an edible acid and/or the acidic salt thereof or an acidic fruit containing an edible acid and/or the acidic salt thereof in the manufacture of food, beverage and health-care products which aims at improving individual immunity.
The invention further relates to a method of using an edible acid and/or the acid salt thereof for manufacturing the food reducing allergy risk and for reducing the allergen of the article which is in contact with skin.

Description

PCT/CN20041000402 (original filed doc.) Drug composition containing edible acid andlor acidic salt, and its usage Field of invention 'Ibis invention relates to a drug containing edible acid and/or acidic salt as active agent to treat and alleviate immune diseases by lowering the humor pH; to improve individual immw~ity by uses of dnrg, food, drink or health care products, which are made from said ed~le acid andlor acidic salt, or the acidic fruits containing thereof, ~ their products; foods lowering the risk of hypersensitivity and their preparation methods; drug to lower the humor acidity and to treat or alleviate disease caused by insects bite; that also to be chug for cold, dnrg for inflammation; dnrg for skin inflammateon, drug for bath agent, agent for treating skirrcontacting material such as clothing and groove, drug for skin releasing, and drug for ~rdiovasaalat thrombus disease.
Back ground of the invention There are four types of disorder immune responses to tissue damage, called hypersensitivity reactions. Type I (anaphylactic hypersensitivity, or immediate type), on account of inappropriate responses to foreign antigens relate to anaphylaxis. 'Ibis anaphylaxis is TgE mediated reaction. Symptoms of IgE
mediated reaction are anaphylaxis, dermatitis, astjrrna, Paticinsonisrn, hay fever, and food alteagy Type II (antibody dependent cytotoxic type, or IgG and IgM
n~diated hypersensitivity), causes diseases such as haemolytic disease of the newborn, autoimmune haemolytic anaemia, nephthy and certain other autoimmune diseases, transfusion reactions, drug allergy and hyperacute graft rejection. 'I~pe III (immune ilex noediated hypersensitivity), is mediated by IgG which causes diseases such as lupus nephritis, rheumatoid arithritis, arthus reaction, vasculitis, and senior sickness. T~rpe IV (T cell n~diated hypersensitivity, or delayed type hypersensitivity), causes diseases such as Type I
hypersensitivity, chronic allergic rhinitis, contact dermatitis, tuberculin reactiosi, diabetes, mtrltipie sclerosis, and erythema.
Immunodeficiency is divided into inherited immunodeficiency and acquired immune deficiency syndrome, which is caused by human immunodeficiency virus (IBV). The susceptible disease for the former group includes, generally, such as respiratory infections, herpes simplex virus, chronic lung, infiue~nza, and skin inflammatory Pa;oients infected with HIV, after a period of apparent quiescence of the disease, will eventually develop acquired irrurnrne deficiency syndrarne. In that period vinrses replicate persistently, and decline the function and rnunber of CD4 T-cell. Eventually, only few CD4 Veils are remained. Drug could just block HIV replication and rise in CD4 T-cells temporary. Finally, most .
HIV infected people devel~ acquired immune deficiency syndrome and die.
However, scientists hope that will be possible to develop effective vaccines against HIV Yet not any effective vane is found.
Tumor is one of fatal diseases which are caused by progmssive growth of a single transformed oelL It is impossible that to remove or to destroy cells must riot kill the ruormal ones. It was that T cells are critical mediators of tumor imrxnmity Being a challenge for immunologists to understand why the mutated proteins can not induce cyrotoxic T cells. The ~ proteins are not only specific antigens of tumors, but also are the causes of cancer: V
based on tumor antigens are the ideal appmach to Tell mediated immunotherapy They are exc~eIlent targets for theaapy Specific antigen vaccine can be pt~oduced from the major antigen of tumor. That may need long time before the major antigen of tumor is identified, and has not as yet Autoimmune disease is caused by a reaction of requited immune system with auto antigens, rxrhic~ does harm to tissues. Autoimmune disease can be mediated by auto antibodies and/or by auto-active T cells. The tissue damage can be resulted from direct attack on the cells home autoantigens, from immune-complex formation, or from local ion. T cells ate not only involved directly in inflammation or molecular desrrwaron, but also arse the required factor for a contmibus reaction of autoantibody Similarly, B cells are impotent antigearpresenting cells to keep a continuous reaction of T-cells. The conhnl of autoimmunity is to know how to control the activity of T-cells, and how to determine the way that autoantigens are ra~nized by T-cells.
There are three groups of drug treating immunological disorders: first, anti-ir~larnmatian drugs of tire cortioosteroid family, such as prednisone and antihistamine; second, cytotoxic drugs, such as azattiioprine and cyclopbosphamide;
and third, fungal and ba~erial derivates, suciZ as cyclospoairye-A and rapamycin, which inhibit signaling events within T lymphocytes.
These drugs have wide action in inhibiting immune system as well as harmful ones. The beneficial effects of ooa~tic~steroids are amti-i~lammation However, there ate also many side effects, including fluid retention, gain of weight, diabetes, bone mirberal loss, and thinning of skin. They are caused by the results of using cortioosteroids which the functions of lw~one and also reduces the immune functions too. The cytotoxic drug suppresses immune by killing cells.
That has serious side effects, inch~dimg debasing immune function, anemia, damage to intestinal epithelium, hair loss, and fetal death or injury. The drips of fungal and bawl derivatives are toxic to kidney area over organs. Besides, it is expensive to ingest for a long period of ant Histamine is a kind of harmful se~aetio~ns in allergic reaction. that is a potent mediator in numerous bidogical reac.~tions. It is formed by the ~zymatic decarboxylarion of histidine that is therefore considered a biogenic amine. In human organism it is virtually ubiquitous in tissues and body fluid, being mainly stored in its inactive form in the metachromatic g~anula of mast cells and basophils leukocytes. Following the stimulation of mast cells and. basoph~7s by antigens, histamines and other compounds are released explosively into the surrounding tissues and body fluids. Qn releasing, histamine fimdions a potent mediator of numerous physiological, and causes pathophysioIogical processes in all organs and tissues. That irnmadiately effects a dilation of the blood vessels, so that fluid escapes into the sun~u~ding t. 'Ibis ion may result in a goal depletion of vascular fluid, causing a condition known as histamine poisoning or histam~e shock.
Ant~istamines are used primarily to control symptoms of allergic diseases such as hay fever, arthritis and Parlainsonism. They alleviate rainy nose and sneezing and, to a lesser extent, minimize conjunctivitis and breathing difficulties.
Antihistamines can also alleviate itching and rash by food allergy.
Chemically, antihistamines comprise several types. Each antzhistarnine neither cures all kinds of syndromes nor is good for any person. Side effects of these drugs inchide drowsiness, loss of concentration, and dizziness. People ingesting antihistamine should not drink alcoholic beverages or pe~'orm tasks g mental alertness, such as driving. Their uses in treatment are questionable.
Besides, the traditional antihistamine could not inhibit mast cells and basophiLs from releasing histamines, from combining the histamines released in the body fluid, from decreasing permeability of the blood vessels, from depressing the irtflarrirnatory, and frrnn enhancing the immunity of cells. Those are the defects of traditional antihistamine.
The antihistamine which inhibits histamine THE receptors could decrease the hives caused by the release of histamine by master cells and eosinophile granular cells. The traditional antihistamines are cott~pounds of amine. As you lmow, amines are high alkaline, toxic to body, damage to the storr>ach, and law solubility in water That the amine does not suitable for being a drug. For iu~noving, the chemist applied acids, including organic acid and inorganic acid to react the amine corr~pomyd to form a salt There are many acids including ink acid: such as hydrogen chloride; and organic acids, such as malefic acid, citric acid, maIic acid, tannic acid and succinic acid; are used.
In a diphenhydramine system, for example, the diphenhis reacted with hydrog~ chloride to form diph~hydramine hydmc hloa~ide; and in a chlorphenizamine system, the chlorpheniramine is reacted with hydrogen d~loride to fozm chlorpheniramine hydrogen chloride. The other compou~s such as chlorphenu~nine maleate, phenyitroxamine citrate, di~hyrlramine tannate, diphe~nhydrami~ salicylate, and chIotpheni~nine malate are the pxs of reaction with organic acids of malefic acid, citric acid, tannic acid, salicylic acid and malic acid, respearvely The role of acid, such as hydrogen diloride, malefic acid., citric acid, malic acid, salicylic acid, and tannic acid, is just a modifi~et:
'That n~ztralizes the alkalinity of arcane, lowers the amine toxicity for patients, and increases the solubility thereof at all. This is the origin of traditional a~atihistamine drugs which are used widely to treat allergic diseases now. Actually, there is not any antihistamine drug that shows perfect effect to allergic diseases. This made the applicant to investigate the other way of therapy and finally succeed.
Food poisoning and insect bit are two kinds of poisoning in daily life, normally The former is mused by eating foods oontainmg disease bacteria or toxin; and the later is caused by venom of insect bite. this toxicity rnuld cause serious imnvune reaction, and may be considered a kind of immune diseases. The traditional treatment is to use anti-toxin and modified toxins for bacterial toxins {such as Diphtheria, tetanus toxin), and to use antivenins for insect venoms (such as black widow, snake). They are produced by vaccinating repeatedly in other animal species. Infusion a large amount of antibodies into the body will induce hypersensitivity The disadvantage of this method is that must test in advance w make sure that the pariea~t has not allergy history.
All the disadvantages of dings for ireaiing immune disease are desc~'bed h~einabove. That made the applicant to study and finish the invention.
Inv~tion content As a result of study, the applicant found that the humor must be kept at acidic condition is necessary to performing immune biology processes. In that way, patl»gens will be killed, effectively, by macrophages, by T cells and by B
cells.
To describe some reasons as following.
1, In imnnme biology, complement is a component of plasma that tags pathogens and presents to macrophages to kifl. Complement also activaEes T cells. The complement system is made up a loge number of distinct plasma proteins that react with one another, and induce a seaies of inflammation responses to fight infection. Complement proteins are proteases that can be activated by proteolytic cleavage. The digestive enzyme pepsin, for example, is stored inside cells and sas an inactive precursor of ~zyne, pepsinogen, which is only cleaved to pepsin in the acid environment (Fianlr, S. T., and Nealis, A. S., Tm~nol. Todax ~ 322326, 1991; Todd, d.A., and Steinman, L., Curt. Opin. Immunol. 5 8389,1993).
The acidity is the necessary condition for the complement to play its sole.

2, Intravesicular pathogens will be bound with MHC class II and presented to 0174 T cells. Peptides presented by MHC class II molecules are gemrated in acidified endocytic vesicles. The effect on pcesentarg cells is the activation bo kill intravesicuiar bacteria and parasiDes in the ~acytic vesicles, where the pH
level is low (Chapman, H.A., Curr. tJpin. Im~rnmol.10, 93102,1998; Pietes, J., Adv Irrnnucml Curr. Opin. Iznrnunol. 75 159208, 2000).

3, For extraoellular pathogens and toxins, they are bound with MHC class II
and are presented to CD4 T cells. The effect on presenting cell is the activation of B
cells to secrete Ig, and to eliminate extracellular bactezia/toxins in the endocytic vesicles when the pH level is also at low {Morrison, L. A., et al., J. Exp.
Med..163 903,1968: Pautnock, D. M., Cucr. Cpin. Imirnutol. 4 344-349, 1992).

4, Some microorganisms such as mycoba~ia ue intracellular pathogens that ~~' PAY ~ PdY~~ of macrophages. They are shielded from the effects of both antibodies and cytotoxic T cells. These microbes maintain themselves in a hostile envin~nment of the phagocyte by inhibiting firm the fusion of lysosomes and phagosomes in which they grow They also prevent from the acidification of vesicles that is to activate lysosoml proteases. Such microorganisms can be eliminated when the ma~hage is activated by THt cell.
In that case, the pH value must be at a lows level.
For intracellular pathogens, the process that MHC class I molecules combine vims envelopes, and present to to CD8 T cells are caused by reaction of proteinase.
The aspaiagic~s are converted to asparkic acids first. Then, all the peptides which are sot on the membrane, are ~ with ca~ohyclrates of residues of aspaitic acid, and eliminated from cells. The hydrolysis rreacti~on of asparaginase is carried out under at acidic condition.
(?ncogenic transformation of cells are associated highly with reducing MHC
class I. Cells infected by adenovirus 12, for example, is much to do with a consequence of change of mutation and very low levels of h~po~ts associated with aatig~ processing 1, -2 (TAR 1 and -2 mRNA ), leading to diminished or absea~t of MHC class L In breast cancer, for example, about 6Q°Io of ~ast~atic tumors lack of MHC class I. Yorl~ I. A., et al., Immunol. Rev,172, 49-b6,1999) 5, Mutation frequently leads to diminished or absent MHC class I , and cases to inrnease the ability of cancer hraasmigration. That results the fact that decreases the chance of vulnerability of cap by T-cells. 'Iherefore, the basic policy of anticancer is increasing the production of complements. It is a problem of row level pH. (lViedermarm, Gc, et al., Imrnunol. Rev 172, 2948,1999; Charles AJ., Immunobiology Sed,161--179, 2001).

6, About 2 % of oxygen can be converted into superoxide anion (~O z } during the respiration of organisms. The free radiCalst;FRs} of sugemxide are extremely active pmdu~ which can react with proteins, sacchatide, fatty acid and nucleic acid FRs destroy the normal struchme aril dishub the normal activities of body;
also cause many damages, such as , oa~iovascular disease, Alzheirr~er's disease, dementia, ~ Pariansonism, imrnunodeficiency of old man, diabetes, inflammation, aging, and Arthritis. They all are autoimmune diseases, and are mostly induced by the damage of FRs (Harm, D., Age 7,111-131,1984.
In humarLS, the first line of antioxidant defense is the antioxidant enzymes, especially superoxide dismutase (SODS glutathione peroxidase (GPX}. These enzymes will help destroy SOR, HZOZ and lipid peroxides.
Fmm the chemical reaction point of view, we know that FRs, especially oxygen FRs, are mainly produced in an alkalrrie gent, and will be reduced by proton in an acidic condition. In this invention, the drug will provide good antioxidant to reduce the FRs.

7, There use many active peptides which are related closely to human physiological functions, such as SOD, opioid p~tides(OI~, imrn~mopeptides(IP}, antrhypertensive peptides(AP}, angiotension I~onvexting enzyn~
intnbitor(ACEI), antithrombotic peptides(ATP}, and casein phosphopeptides(CPP}. These peptides are fom~ed urxter acidic condition, and perforn~red their mles at the same.
The SOD, for example, etches FRs only under acidic condition. The reaction of FRs and antioxidants oaau under the acidic oon~dition, as shown in the following reactions. If not under acidic condition, the reaction can not occ~u to right side.
And there is not any work to scavenge.
02-°--w02 °~Hy~z '~ ~~f-j °~HzO (1) ~ Hz0 ~o2+~a2 + 2H+ +~ H2o2+o2 (2) The FRs is the major factor in causing disease. If the FRs being removed, the disease so does. In treating and alleviating disease, the drugs of present inv~tion show very widely functions, because of their excellent properties of hRs scavenging.
The neessaty condition for the structure activity of ACEI is that there is a positive charge at guani~dino orb-amino group connecting to C-end of the peptide.
That proton plays a substantial mle of function. As for the affinity of CCP
foz calcium, is caused by high level polarity of the residual group of serine phosphatide and by the stabilization effect of calcium phosphate colloid in acidic oorxlition. It proves that how the amino acid residues affect on the physichemical action, especially, for binding ability of proton. They are determined by the acidity of solution. Therefore, the drug of this invention provides functions of pmeventing and depressing hypertension.
In tissue, arachidonic acid (AA) is reacted by lipoxygenase tZ0) to form its derivatives, such as 12-hydtnxy eicosatetraenoic acid (12-HETE} and leukodriene (LT). These products cause irrflarnnration and hypersensitivity re<xtions. AA
is atso reacted by cycloxygenase to form prostacyclin tPGX, PGI~, ihmmboxanes I'XA~}, PGAz, and PGF~. 12-HETE activates human granulocytes. While 5-HET'E is a ~ of slow-reacting-substance {SRS) of hypersensitivity (Siegel, M.L, et al., Prnc. Nazi. A~cad. Sci., 77, 308-312,1980). This mdi~s that there is a way to inhrbit hypetsearsitivity and inflammation by inhibiting the rextion of LO.
AlmEOSt all animal and vegetable Iipooxidase {soy bean) have the biochemical activity That can be used as an inhibitor for vegetable L(?. They are also proved that they inherit LO to prod>bce derivatives from platelets a~ I~ocytes.
(Baartrrann, J., et aL, Prostaghandins, 20, 627-639,1980).
1n the productions of prostaglandins (PGX, PGhy azbd thnomboxane Az (TXA~
from AA, by cyclooxygenase, we found a very close relationship between the metabolisms of lipoperoxidation and prostaglandins. This relationship leads us to firxl an effective antioxidant for protection. The lipopenoxidation needs a tra~oe amount of hydrog~ peroxide to initiate a ream at the active enzy>ne site of Fe+3 of hemoglobin, and to ptnduce oxygen FRs. The FR then gains a hydrogen atom from AA, and induces reaction. To eliminate FRs in advance, then there is no cascade to form the TXAz from AA. Aspirin is one of NSAIDs {zrorrstnoid anti-inflammatory drugs). Its is proved in clinic that the reaction of aspirin inhibits die activity of cyclooxygenase, and then reduces the ooagulai'ion force of platel~.(Chau, K. Z., ~ygen free radical and clinic, 370, Hou Ki publisher Taipei, Taiwan, 2003).
Thrombus and embolus are ptvduoed by activated glatelets. 'Ibis coagulation cascade begins a series of complicated reaction one another when the damage to endothelium is happened. Releasing TXA2, derived from AA, into plasma is the key point of clumping process, which promotes the formation of small embolus for clogging blood flow.
The drug of this invention inhibits the activity of cyclooxygenase that inhibits the cascade fon~nation of pn~aglandin, and depresses the release of TXAz. When the formations of embolus and thrombus are inhibited, there is no way to induce cardiovasailar disease, such as intracerebral and hemorrhage, and myocardia infa~. To release TXA2 from platelets is the first message for inducing platelets to enhance the reaction of coagulation. That is the first step of clotting fornoation of platel~. In that case, if we mold inhibit the release of pr~tagtandins or inhibit the activity of cyclooxygenase, we could inhibit the whole cascade of prostaglandins, and could eli~nate the possible formation of thrombus, finally Human body has the ability to reooves its natural defense in a propex condition, but will lose it when the body is wear For recovering innate immunity, of cause must shengthen the body at first. The mostly basic m~e~od is accoidirig to im~nobiologic medianisms. Shat is to make it sure to raise a large number of complerrierit and to supply a good environment for the immune cells, such as marophage, CD4 T-cells, and B-ceIts to work. In. other words, to make ~ acidic hun~ar or to lower the pH of humor is necessazyc That the immune mechanism could only perform in an acidic situation. This reason makes the applicant to investigate the other way of therapy And finally, found that making an acidic situation in humor by ingesting acid co~ound which can enhance the ability and the functions of noaranphage, CD4 T-cells and B-cells effectively To use the acidic and etlible chemicals far that purpose is the key point of this invention, and dissolve the problems of immune diseases.
The poison problems, such as food poison and insect bite, cause immune reaction in body Dings of this invention provide treatment in this area. The mechanism of present invention is increasing the level of acidity of humor to enhance the ability of immunity and to neutralize the toxin. Because all the toxins are proteins they could be neuhnlized or denat<ued Saliva is a kind of humors and, noirilatly, has the pH of around 6.8. For the purpose of reference, to test the pH of the saliva of a man was parried out, who had bn~stied before testing and ingesting 700 mg of citric acid. Data are taken in an interval of 30 minutes for 2 hours. The results are listed as shown in table 1.

Table t The pH vahre affected by acidic food Testing time 0 20 60 90 120 (minute) pH 6.8 6.45 6.26 6.6 6.8 Though, the pH of saliva and urine will change in case of any acidic substance entering the body by biological mechanism. The buffer aaron will make the blood back to around the neutral quickly, but is at acidic side. In the other words, the neutralization of acid is perforn~ed partially by the calcium ions released from bone. It is apparently that the pH Wing to around neutral, but there are much of ions of calcium and of proton in humor: The pmbons take part in acidic reactions; and the calcium ions are corx~rned to transformation of immune signals and to activating ralcineurirr. Because of calcineurin itself is activated when the lymph cells are activated and increasing the calcium ion in intracellular:
The hype~nsitivity reactions cause inflammation seriously in organs. l7rugs of this invention have the function to lower the humor pH and treating or alleviating immune diseases that would be a good intlamination inlnbitor.
Brief summary of the invention A~ordingly, it is an abject of the prre<sent invention to provide dnrgs to treat and to alleviate immune diseases by lowering the humor pH with edible acid and/or acid salt The drug contains effective amount of edrble acid and/or acid salt as active agent and pharmac~tical acceptable carrier.
It is provided the use of a drug for tr~eatlr~rt or alleviating imrn~ure disease by lowering the humor pI~ which is prepared with edible acid and/or acid salt.
The invention is to provide tire uses of food, drink and health care producx for improving individual immunity, which is prepared with edible acid and/or acidic salt, or the acidic fruits containing thereof, and their products as alive agent.
It is the principal object of this invention is to provide a method to produce lower allergy risk food, irrclu~ding foods treated with solution containing edble acid and/or acidic salt It is therefore a general object of this invention is to provide a drug, containing edible acid and/or acidic salt as active agent and pharmaceutical acceptable c;urieT, for treatment or alleviating food poison and insect toxicity disease by towering the humor pH.
A f~uther object of this invention is to provide an inflammation drug containing edible acid andJor acidic salt as active agent by lowering humor pH.
An additional object of this invention is to pmvide drugs, containing etfbie acid and/or acidic salt as active agent, far cold, for bath agent, for hair lotion, for the release of drugs to the skin, for treatment of cloth and it prodt~s, for thrombus and embolus, for free radicals scavenger, or for analgesic.
Otter and further objects of this invention will beoom~e obvious upon an undeWarrding of the illustration embodiments about to be described or will be indicated in the mended claims, and various advantages not refen:~ed to herein will oa,~ur to one skilled in the art upon employment of the invention in practice.
lDetmled desariiption of the invention:
This invention uses edible acid and/or acidic salt as active agent that does no harm to the body absolutely: More over, the function of this invention is to obey the most basic misms of biophysics and to scavenge free radical, but do not inhibit just one function. As for an antt'histamine thug, for example, only one kind of receptors can be inhibited. This invention uses edible acid arxllor acidic salt as active agent that is more remadCable different from the traditional dings, and that is the specific property of this invention. The drug's component of this invention lowers the humor pH and combines histamines released from mast-cells, T-cells, eosinophil5, neuiraphils and basophils, and fits the receptors.
The dn.igs also increase production of complement and enhance the immune abilities of maa~ophage cells, Tells and B-cells. And recover imirnme mechanism, anti-inflammation, anti-analgesic and lowering vascularpermeability Antihistamines are the traditional drugs used in tl~earing allergic diseases.
Their mechanisms are a kind of ~etitive reaction wig re~tas between antihistamine and histamine. The release of histamines fium mast-cells, from basophiLs, and from eosinphils is can not avoid, when the ant~istamines fail to react with histamine receptors earlier than histamine. That is why in treating a serious aElergic Patient must give epinephrine first, but is not antihistamine drug.
Thus, the patient must ingest antihistamine drug always to avoid the reaction of histamine, and has to suffer the side reactions of antihistamine all times.
The present drugs do not contain amine group, and show no side effects lice traditional antihistamine. Another advantage is that many drugs of present invention are metabolic ones. ?hey can be arnverted into energy to supply cells to perform the immune work dic~ectly These am also to be good antioxidant, scavenging frae radical effectively, to improve inununity, and finally keeping diseases away ALI these pmp~ties are not found in the traditional dzugs.
One of drug allergic reactions is penicillin anaphylaxis. That is caused by the ormation of cvalent bomdings betwe~ f3-lactam ring of penicillin mdecule hapten) and amuioacid g~ups of host rotein.
These penicillin modified self peptides can provoke a THZ response in some n individuals. These THZ cells the 'vote 'cillin-bindin B-cells to I

us, pencillin acts both as B cells antigen, and as T cells antigen by m~odify~

tides. When 'cillin is ' 'ecbed intravenousl into an all 'c individual ~~nicillin-modified proteins ran crass-link IgE molecules on the mast cells, anaphylaxis. Pnicillin anaphylaxis can be avoided in us ~~g of this invention. For the same reason, the death caused by vaccination also improved by applying the drug of this invention.
Bah systemic anaphylaxis an,d vaccination accident could be improved, by combining the ingestion drug of preset invention in advance, at the same time or after their pnoc~ding.
One benefit of this drug composition is that most of them are natiue food acids and acidic salts. they can be eaten in large amount. And besides, pounding with other drug, foods and trying on foods one also possible.
The applicant found that edible acid and/or acidic salt as xtive agent for the ri~eatment and alleviation of immtme diseases by lowering pH are acids, such as fumaric acid, succinic acid, n-hydroxy acids such as malic acid tartatic acid, citric acid, ludic acid, a-hydroxy octanoic acid, gluooaolactone, gkolic acid, acetic acid, phosphoric acid; acidic citrate comprising sodium d~ydrcgen citrate, sodium hydrog~ citrate, potassium dihydrogen citrate and potassium hydrogen citrate;
acidic succinate comprising sodium hydrogen suocinate and potassium hydrogen su~nate; acidic tartrate comprising sodium hydrogen tartrate and potassium hydrogen tamale; sodium hydrogen malate and potassium malate; acidic phosphoric comprising sodium, dihydrogen phosphate, disodium hydrogen phosphate, potassium d~ydmgen phosphate, and dipotassium hydrogen phosphate;
and their cornpourtds; show wonderful effective in treating immure disease.

in the list of FDA (The Food and Ihug Administ~on), the drugs of pit invention are listed as GRAS (Generally recognized as safe). Because of that, there is not any problem concerned about the toxicity In the drug given by injection, we must apply small dose for the direct injecting into the tumoa:
The drugs of present invention have usages of oral and none oral. The proper therapeutic dose is about O.I ~ 300 mg/kg /day, in generally In special else, the ingestion dose could be much more than that aooorrling to necessary They can be prepaa~ad in any forms of dnag by the known pham~eutics, and even combining with other active oompooents.
Routes of drug administration of preseat invmay be by parentetal method, including subartaneaus, inframuscular, intravenous, in~d~mal, intra_arter;al, intravasailar, intrabumo~, transdesmal, inhalation, suppositories, ointments, aerasoLs, inhalants, tinchues, plasters, lotions, and miactures. The liquid solvent includes water, alcohol, glycerin, and ocher glycols.
The dsspensing of mediratic~ for injections is following the traditional method.
To use sterilized pure water under a clean room, adjusting buffer and tonicity by sugar and salt are usually taking care of. Beside the solvent of water, ethylene glycol and polyol, such as glycerin, Propylene glycol, liquid poly glycol, and mixtures are also used Powder made by vacuum freeze-dried method is an ideal way The effective drags of present invention could oompoimd with inert dilution agent, eatable carrier, sweeteners, perflrtr>er, herbs, foods, other rnririents, and their compounds.
The oral usage of present invention could be in the forms of capsule, table flake, pile, lozenges, solution, suspension liquid, syrup and blending with food The active agent of said edible acid and/or acidic salt is also used in foods inching biscuit, cake, candy, chew gum, Puddings, dairies, peanut products, drinks, carmed foods, cooking foods, and other p»ssed foods. These products are coating widr oa~ containing the drug thereof. The effective agent of this invention in the product is 0.0610°l0, prefer is 0.1--7%, better is 0.2-r4%, and the best is 0.3~2°l0. (to be proved in example of table 5) The active agent of said edible acid andlor acidic salt is also used in drinks comprising juice; wins including fruit wins, whisky, rice wins, brandy, sake, beers, herfi wins; soft drinks, carbonated drinks, teas, mineral waters, alcoholic drinks, spoils drinks, ftuictional drinks, coffees, colas, sarsaparillas, dairies suds as fermented milks, and herb solutions. They contain the effective agent is ranged in 0.06 I0°!o, prefer is 0. I ~7%, better is 0.24%, and the best is 0.32 %.( to be proved in examples of table 5) Edible acid andlor acidic salt of the present invention is used to treat proteins contained in foods w foitn denature. The amount of ding is up to the necaessary of protein contained. It is better above the stoichiometrical quantity Clothing, such cloth and groove, contacting skin causing all~ic readier, can be iz~roved by using drugs of this invention do treat the allergens and proteins contained thereof to a denatlu,e state. The skin contact alleagic reaarons could be inhibited.
For the same reasons, Basted drugs used in meabng skin or drug foe' skin releasing are usually compounding with anti-allergy component, such as aspirin or other antihistamines, to inhibit allergy reactions, such as achy In that , both aspirin and traditional antihistamine c~wse damage to body as descn'bed hereinabove. 1f using dings of this invention, not only can show the pr~e~es of anti-inflammation and anti-allergy reactions, but also activate skin and incaease the ahwrbing effective of skin.
The present invention relates to a drug containing edible acid and/or acidic salt as alive agent for the ireatrnents of anti-inflarrnnation and anti-hypersensitivity by loweetinng the humor pH. That could be wed for hair tonic and hair lotion to treat head skin diseases, such as itchy and scale, and to protect hair and skin. In washing hair, the alkaline soap compounds are always on hair and skin, when bacteria are growing in the hair folliculitis and causing itchy and scales.
Drugs of this invention are acidic oo~ounds and just show good effect for improving and inhibiting inflammation and itchy By the same action of present invention, the anti-inflammation and anti-aile~gic reaction could be applied to inhibit and to treat diseases of cardiovascular thrombus and embolus.
In oral agents, including food and drinks, of this invention, can contain the normal rompon~ts, including: binding agent such as starch, glycerin, polyethylene, pyrrolidone, acrylic acid-iso bomeol copolymer, acrylic acid-2-ethyl hexanoate , Ca-CMC, CMC, gelarin, gluon, ethylene acetate, acacia gum, polyethylene, arabic gum, and ~ gum; densifier such as propylene glycol alginate; softener such as D.B.P; dispenser such as calcium carbonate, polyethylene glycol, stearic alcohol, fluid paaa~n; emulsifier such as Span-60; preservative such as ethyl p-hydroxy benzoate; lubricating agent such as magnesium stearate, talc powder; ~ such as papain and bromelin; sweetaer such as sugar, glucose, brown sugar, syrup, honey, fiuctose, maltose, lactose, oligomes; perfurriex such as peppermint, peppermint oil, essential oil, green oil, strawberry essential or'I, ethyl isovalerate, iso amyl butyrate, cocoextracte; pigment such as caramel, chlorophyll; herb such as gambit, garlic, leek, chive, shallot, ramson, scallion, zinger, tang-kuei, licorice, astragali radix, arrr~eniacae semen, fritillariae cirxhosae bulbous, atiactylodis rhizoma, pinelliae tuber, angelica sinensis radix, hoelen, asini gelati~num, citri sinensis ezocarpium, asparagi radix, rehmatmiae radix et rhiwma, perillae ftucws, perillae caulis, aneman-henae rhizoma, albae sinapis semen, mori radicis cortex, zing~beris siccatulm rhizoarr~a, lily bulbous, sesame, ginseng, coffee or caffeine, tea, in powder or extracts; another nutrition such as mineral, vitamin, powder milk, peanut product; vegetable seed oil, cooked foods, amino cads; and their compoundso The acidic fruits which contain the effective agent g~ than 0.3%, such as plum, oe~nge, pineapple, star fruit, grape and grape fruit could be used as drug.
The content of effective agent in processed product is pref~nce for 0.3% than 0.06%.
As an oral drug, when the effective agent compounding with food, the dose would be changed depending on the amount of food ingested. In a low amcenhation of effective agent, food must ingest a greater amount rather than a higher cor~entrarion one. Taking 300mg/dose, for example, a man ingests SOOmI
or SOOgr of food once a time when the food must contain 0.06% of effective agent The normal quantity of drink is about 250m1 or 250gr, when the same agent of 300mg/dose in it is 0.12%. But the patient ingests drug with water is about IOOmI or 100gr a Lime, when the c~centmtion of drug in food is 0.3%. By this relationship described hereinabove, the content of dmg of acids and/or acidic salt is 0.06--100%, prefer is 0.1--100%, the better is 0.2100%, and the best is 03100%
(to be proved in example of table 4).
Therefore, the amount of edible acid and/or acidic salt contained in foods, dishes, drinks or health care products is 0.06-100%, prefer is 0.1100%, the better is ~s 0.2-100%, and the best is 0.3--100% (based on the total weight of food, drink or health care product in wtlwt).
1?tesent invention, accordingly, edible acid and/or acidic salt cou)d be used to treat food An allergic food is a food, such as milk, contair>s active proteins which could cause people allergy disease. The allergy disease could be inlubited by denaturing the active protein. 'Ihe agent of pmesent invention is the best one to de~at~u~e the allergic protein. 'The ~ri~ati~ of edible acid and/or acidic salt is 0.0fr-10%, prefer is 0.1 ~7%, the beer is 0.2--4%, and the best is 0.32%.
For food allergy-sensitive person, sea foods, especially crab and shrimp, are very patent allergens. There is one way to prevent the immune disease from eating those foods. To add a pmper amount of effective component of present invention in processing sea food is very suitable. The pmduct of suds treated sea food not only can avoid the allergy reaction, but also prevent the unsaturated fiish oil from oxidation because of the antioxidant reaction of e~Ctive component.
The efficient of present invention drugs for immune disease is pton to the number of acidic group contained in the same compound. The citrate compounds, for instance, the power series is as following:
Citric acid > dihydrogen citrate > monohydrogen ciliate In this invention the individual means any spondyle animal, the better is mammal, and the best is human.
C6can-~p>el This invention will be understood more readily with refec~oe to the following examples. These examples, however, are intended to illustrate the invention and are not meant to limit the scope of the invention.
Example h29: [Anti-allergy reaction]
This is a comparative testing of drug depressing effect on the amount of leaching histaminens when is treated with 48/80(Sigma, St MO, USA) oornpourid.
(1). Preparation of leaching cell solution from mouse body A mouse is killed and bloodletting. Then 10 ml of Locke's solution containing 0.lolo bovine serum pmtein is injected into its abdominal cavity After abdominal cavity being light massaged, the cavity is cut and the Lacke's solution is removed.
Cavity is washed with another 5 ml of L.ocke's solution, and this washed solution is added to the late one. This combined solution is cen~ifuged at 600 rpm fos 5 minutes. The sediments are washed with 5 ml of cool L.ocke's solution. Adding 3 ml of cold Locke's solution to the washed sediments, then a leached cell solution of abdominal cavity is obtained. The composition of Locke's solution is: NaCL
9.1010, KCL 0.2%, C~O.15%, glucose 1.0%, in w/v, and the rest distellared water:
{2~ Ding depressing effect on the amount of leaching histamines when treated with 48/80 cmr~pound.
Each testing compound listed in the table 1 is dissolved in a Ringer's solution containing 1 % NaHC03, and then diluted with Locke's solution to the indicted tratian. 1.0 ml of each of those solutions in last team is mixed with 03 ml of mouse's leading cell solution and 0.5 ml of Locke's solution. This mixture is cultivated at 37 °C for 5 minutes. 'then adding 02 ml of L,odCe's solution of 48/80 c~r~ound (1 mg/100 ml) and cultivated at 37 °C for 10 minutes.
Then the reaction is stopped by cooling, and ~n~'uged at 2,500 rpm for 10 minutes. 1.7 ml of decanted solution and 0.3 ml of sediments ~ obtained. O.lml of waber~'nd 0.2 ml of 100% trichloroecetic acid are added to the decanted sohition. 1 S ml of Locke's solution and 0.2 ml of 100% trichloroacetic acid are added to the sediments washed solution. They are cultivated at room temperah~re for 30 minutes. After cultivation, the mixtures are cent at 3,000 rpm for 15 minutes, respectively 0.35 ml of each of the former two solutions is sampled. 1n each sample,1.65 ml of water, 0.4 ml of 1N NaOH and 0.1 ml of OS% OPT (o-phthalic aldehyde) in methanol are added a~ cultivated at room ternperariue for 4 minutes. The is stopped by addimg 0.2 ml of 2M citric acid. And finally, detelxrrine the amount of released hista~s in the tested solution by fluorescence method By the analysis, results of the depression rate of histamines could be calculated.
Locke's solution is instead of ea~c~ d:ug in ~I pup, and instead of both drug and 4$/80 compound solution in blank group. The histamine releasing rate {A) can be calculated by following equation. Where (Hs) is the total amoucit of histamine in the decanted solution, and (Hr) is the total amount of hisramir~e in the sediment. (A) _ (Hs)!{ (Hs}~ (Hr) ) x 100%. Then the depression rate is:
=100 - [(A- A in blank group) / {A- A in control group)] x 100%.

The calculated results are shown as following table 2.
Table 2, Drug depressing effect TestingTesting drug HistamineDepression_ No. 100(mg/ml) releasinglate ~ (~) (~) Control group Control 90.5 -Blank group Blank 9.0 -(1) Trisodium gly~cyrhizinate65.5 30.9 {2) Diphenhydrami~e hyd~lotide64.7 32.1 (3) Diphenhydramir~e citrate60.2 37.5 (4) Succinic acid 8.9 100 (5) Citric acid 8.7 100 (6) Lactic acid 8.9 100 (7) Malic acid 9.0 100 (8) Tartaric acid 89 I00 (9) )?uric acid 8.9 100 (10) a-hydroxy ethanoic 9.0 100 acid {1l) a-hydroxy octanoic 9.0 100 acid (12} gluoonolactone 8.9 100 (13) acetic acid 9.0 100 (14) propionic acid 9.0 100 (15) ascorbic acid 9.0 100 (16) sodium dhydrogen citrate9.0 100 (17) disodium hydrogen citrate58.6 39.1 (18) potassium dt'hydrogen 9.0 100 citrate (19} dipotassiumhydrogencitrate57.9 40 (20) sodium hydrogen sucW 9.0 I00 ate (21) potassiumhydrogensuccinate9.0 100 '~, sodium hydrogen tarrrate9.0 100 (22) I

' (23)potassiumhydrogen tartrate9.0 100 ~s (24) sodium hydrogen malate9.0 100 (25) potassium hydrogen 9.0 100 malate {2~ sodium hydrogen maleate9.0 I00 (27) potassium hydrogen 9.0 100 maleate (28) sodium hydrogen fumate9.0 100 (29) potassium hydrogen 9.0 i00 fumate (30) phosphoric acid 9.0 100 (31} sodium d~hyrlrogen 40.5 38.6 phosphate (32) potassium d~ydrogen 40.0 38.0 phosphate (33) disodium hydrogen phosphate21.0 14.7 (34) clipotassium hydrogen 20.0 14.4 phosphate Trisodium glycy><rhizinate, diphenhy~lrnine hydrochloride, and dipltenhydtar>mne cit<ate are traditional antihistamines. To compare the results of diphenhydramine citrate and citric acid, we could realize how poor the traditional antihistamine is. It is quite obvious that the results of drugs of present invention show completely affective while the t<aditional drugs are incompletely The inhibiting effect of histamine can also inhibit the production of compounds, such as 12-~ LT, PGX, PGIz, TXAv 1?GA2 and PGF~, of course, there is no thrombus disease happemd.
Example 35-45: [Anti-delayed type allel!gy reaction The weights of testing mice are ranging from 20 g to 30 g. They are coated ed with 0.1 ml of oxawlone alcohol solution (OSwfv %) on the hair cleat~d part of abdomen. After five days, each of the listed drugs is dissolved m oxazolane acetone solution (OS w/v %a), and 101 eat of the solutions is token by micao Pip~.te to coat on both sides of the right ear. After 24 hr, the mouse is killed by ether and punched a circle area of a diameter of 5.5 mm on both right and left ears in corresponding Part by a Fund~er machine (potions of drug coated and the blank).
The punched portions are weighed and the inflarnrnation rates calculated. The c~ntr~ol group one only with the oxawlone acetone solution {0.5 w/v %}.
The inflammation depressing rates of each dnig are calculated by following equation:

lntlannrnation depressing rate (%) _ [(wt. of drug-coated right ear) _ (wt of nan-drug-coatad left ear)] x 100% /(wt of non-dug-coated left ear) The inflammarion depressing rate of each drug is shown in table 3.
Table 3 Testing Drug-coatedMouse Depression No. Testing drug Amount rate (n') (35~ Diphenhydramine 1 6 20 hydrochloride {3~ Diphenhydracnine 1 6 25 citrate (37) Suocinic acid 1 7 96 (38) Citric acid 1 7 100 (39) Lactic acid 1 6 97 (40) Malic acid 1 7 96 (41) Taitazic acid 1 7 97 {42) Fumaric acid 1 6 98 (43) a hydroxy ethanoic1 6 98 acid (44) a-hydroxy octamoic1 6 94 acid (45) gluconolactone 1 7 97 Table 3 shows that the anti-inflammation rates of traditional anti histamine drugs are very poor in comparison with this invention. Dnig could be anti-inflation, is also could be analgesic.
Example 46 [Testing in sea food eating]
An adult man who is very serious allergic to sea foods, especially shrimps, he ingestes two capsules of this invention drug {1,000 mg, 30 wt % of garlic and wd% of citric acid) before eating shrimps. After ate many shrimps there is not any symptom of allergy at all.
The same people before eats crabs dishes have ingested tow capsules of traditional srmng anti-histamine (ooniainimg trisodium glycyrrhizinate 108mg, oratic acid 60mg, chlorphenirarnine Smg, Ta Fong Co,.). No sooner he have ate, he feels bad in tasting and fells sick very bad when he have been sent to hospital for tceahnent.
Example 4752 [treatiing cold]
The oral dose of this invention such as tablet and capsule can ina~ease the number of tablet or capsule, et the active agent which is blending with foods the is limited by the amount of foods eaten one tine. The following examples will explain how the effective agent of drug is required in a food of 100m1 volume.
There are six different doses (l0mg, 60mg,100mg, 300mg, and 600mg of malic acid? of testing solution, which vontent the basic vompounds of water 100 ml, l~Pyl~ P~Y~I ~ll0.1 g, fructose 10 g, garlic 300 g, zinger 100 g, angelica ainensis radix 10 mg, honey 3 g, armeniacae sewn 10 mg. These six drugs are given six gtvups, S patients per gnxap, of catching cold patients individually per tow howl a time. The ingestin of drug is when ttbe cold sytxfrOmes are improved. The effect of drugs by treating time is listed in Table 4.
Table 4, Time and dose for treating cold Example 47 48 49 50 51 52 Dose, mg 10 60 i00 200 300 600 Rate of malic 0.01 0.06 0.10 0.2 0.3 U:fr acid in foods, %

T'u a for treatment8 4.S 3.2 2.2 1.6 1.1 *, ~Y

ranking Poor good betterbest excellentexcellent *: the time for treatment needed is the avea~age of the same group.
Therefore, the content of this invention in dose must be expressed in 0.06 100%, good is in 0. l ~ 100%, better is in 0.2~ 100% and the best is in 0.3--100%.
Normally, the higher the concentration, the little amount of foods could be taken is.
in the medicament there is a regulation of mgJday/kg for the toxic drug, while the this invention is belonging to foods and it to be better expressed by rnn~ntratian in food ingestion one time.
Example 53--63, Testing the upper limit concentration of drug for taste of drug containing foods.
When applies the this invention to foods and lowering the risk of allergy or health care foods, a higher drug content is better for the disease, but a taste problem will be faced. There is needed bo limit the drug content Taste testing is out as follows.
To make WU LOONG tea by 250 g of tea with 8.3 liters of 80°Cwater and 420g of sugar is added. Different doses of 1g, 2g, 3g, 4g, 5g, bg, 7g, 8g, 9g, 10g, and 12g of maiic acid are added info e~h set of 11 wps of 100m1 Wu LOONG tea individually Let 6 volunt~ to test the 11 cups of tea individually Each person ranks the taste of teaby five levels of best, better, good and acceptable and can not acceptable. The results are shown in Table 5.
Table 5, The results of taste testing F,xampleAmount Best Better Crood acceptable of malic acid, 53 1.0 6 54 2.0 6 55 3.0 2 4 56 4.0 d 57 5.0 3 3 58 6.0 1 5 59 7.0 6 60 8.0 4 2 61 9.0 2 4 62 1.0 6 63 12 not acceptable 'Ihe results shows that the levels of acceptance are: the upper limit of acceptable cono~tration is <10%, good is ~7%, better is <4%, best is Q%, and not acceptable is 12%. To combine the test data of lower effective limit concentration in exa~le 52, the concen~ation of drug in foods must be: norrrmlly is 0.0610%, good is in 0.1--7%, better is in 0.2M4% and the best is in 0.3--~2%, .
Example 64, Oral syrup of orange skin z2 The formulation comprises SOml (62% alcohol) of orange skin tirKxure, 50g of citric acid, 15g of talc powder, 850g of sugar and the balance is distillated water to make 1000m1. This mixture is filtrated, sterilized and bottled as product Example 65, In~ion -To dissolve 36g of citric acid and 34g of potassium dr'ltydtngar citrate in a total volume of 1000m1 of sterilized water, then the solution is sucking filtrated through a c filter, arxi filled in 10m1 ample by noRrnal GMP procedure in a clean room F.~tample 6b, Gintrnent To mix 1 g of tartaric acid, 0.5g of potassium hydrogen tartrate, l Og of fluid pataffin and the rest of Vaseline to make up to 100g, the mixture is grorituid and bottled to produce a 1.5% of potassiumhyrlrogen tartrate ointment Example 67, Capsule Grinding and oornpourrding 3508 of citric acid, 200g of garlic powder, SOg of zinger powder, lOg of angelica sinews radix powder, lOg of armeniacae semen powder and 3008 of fiuctose, and the compound is euca~psulated to 1000 pieces of . . . . .
product Example 68, Crrarrular and tablet The formulation comprises 30g of malefic acid, 20g of com starch, 20g of lactose, 5g of Ca~IVIC, 5g of polyethylene pyrrolidone, and lOg of talc. To grind malefic acid, com starch and lactose to fine powder; then the compound is produced in a product of 1--2 m/m granular by normal granular mane, using 5% water solution of poly ethylene pyrrolidone as a birxle<:
To mix talc and the granular, and then product of 100 tablets of containing 300rng malefic acid are produced by tablet machine.
Example 69, powder The formulation comprises 50g of fumaric acid, 4008 of micz~ocxystalline cellulose and 550g of corn starch. To dissolve the fumaric acid with 200m1 of pure water and being ~ by micznaystalline cellulose, the product is dried and then mixed with cam starch to form a twenty folder powder Example 70, Pills The formulation comprises SOg of succinic acid, 2 g of potassium dihydnogen phosphate, SOg of glycyrrhizin, 5 mg of ginseng, l g of zingier, 5 g of starch and 50g of honey To pulverize succinic acid first an then cornpotu>diztg with other components by a , and finally a pn~duct of 150 pills containing 320 mg of succinic acid per pill are produced by a pilling machine.
Example 71, Troches The formulation comprises 100 g of a-hydroxy ocranoic acid 80g of gelatin, 200g of glycerin, 20g of acacia gum, and 160g of perfume water. To pulverize the a-hydroxy oc~oic acid into powder first and is addeCl to the transparent solution that is prepared by following steps. Gelatin and acacia gum are saftet~d with proper apt of water, then glycol is added and heated to form a ~t solution. Into this sohztion the powde.~ a-hydroxy octanoic acid is added and mixed gently, poured into a mold and cooled to as products.
Example 72, Emulsions The formulation comprises 100g of succinic acid, 20g of spa~n~0,100mg of ethyl ~-hydroxY benzoate, and the balance amount of peanut oil. Pulveri?in~
the mixture of succinic acid antl span-60 by grinding machuie, then ethyl p-hydroxY
benzoate and peanut oil to make a total volume of 1000m1 are added and mixed str~gly for three minutes, and bottled as products.
Example 73, T'mcfure (non-alcoholic solution) The fomrulation comprises 6g of a hydroxy ethanoic acid, 47g stearic alcohol, and 47g of ethylene glycol. To melt the mixture of a hy~droxy ethanoic acid an stearic alcohol on steam, then ethylene glycol is added and mixed well to form a non-alcoholic solution containing 6% a hydroxy ethanoic acid Example 74, creanns The formulation comprises :A part are 15g of stearic acid, 5g of hexadecarwl, 5g of polyethylene glycol, 4g of flood paraffin, and Sg of citric acid; and B
part are l Og of glycerin and pure water to make up a total weight of 100g. Pacts of A and B
are prepared individually and ~ by normal process, and finally 100g of Imam am produced.
Example 75, Inhalations (spray) 'Ihe formulation comprises 0.25wt% citric acid, 33 wt% of ethyl alcohol, and the rest is propellant I2/114(20:80). Both atomizers and materials are cooled under -30°C before to use. To dissolve citric acid in ethanol and add the proper unount into atomizer, after the proper amount of propellant is added closing the valve of atomizer, and the products are obtained.
Example 76, Blending foods {canned fish foods) 10 kg of sardines are washed. After their heads and tails being cut and the inner organic being cleaned up, they are cut into a proper size. These raw materials are cooked in a 201 solutionthat contains 1.2 kg of salt and 800kg of citric acid.
'The cooked fish then is canned into Na.4 size steel can with 75g of tomato ketchup; and the product then is sterilized by norrrgl process.
Example 77, Blending in foods (cookies) The formulation irises lOkg of wheat powder, 3.Skg of sugar 0.8kg of slwrt~ng oil, lkg of millet jelly, 0.03kg of salt, 0.2kg of ferment, and 0.62kg of a-hydroxy ethanoic acid. To follow the traditional rt~ethod of cake malting, the colds of wheat powder, sugar, salt, and a hydroxy ethanoic acid ane ground and sieved individually first They are mixed them with ferment and part of wheat powder, and compounded well with millet jelly and shortening oil. After shaping, and baking in two stages; first stage is at 180200°C, and the second stages is at 150205°C; products are produced.
Example 78, Blending in foods (cakes) The formulation comprises lkg of wheat powder, lkg of sugar, lkg of egg,150g ~s of gluconolactone, and 300g of water.: The albumin and egg-yellow are separated first, and the former is bubbled by baring. After the albumin is bubbled, sugar, gluooniolac~ne, and water are added and mixed homogeneously The wheat powder is sieved an,d added to the mixture. To mix quietly and being molded for baking, then rakes are per.
Example 79, Blending in foods (cads) The formulation comprises 4308 of white sugar, 350g of starch synip,170g of invested syrup, SOg of gelatin, 20g of potassium d~ydnogen citrate, 20g of sodium d~ydrogen ciri~ate, and 2 ml of vanilla extract Gelatin is cut into pieces before dissolving in triple volume's of water, and heated with steam in a doubled layer bottom kettle. Following the process of soft c~dy making method; dissolving sugar starch syrup and inverted syrup; cooking; adding potassium dihydrogen citrate, sodium dihydrogen citrate, and vanilla extract mixing even; adding dissolved gelatin; mixing carefully, degassing; powdering molding; cutting;
pacing; and finally the products are obtained F.xalnple 80, Blending in foods (chewing gum) The gum base fvnnulation con~rises SOOg of 50% liquid solution of polyvinyl a~tate,150g of D.B.P, 200g of calcium mate, and 50g of wheat powder.
210g of the gum base is compounded with 50g of malic acid, 650g of sugar,100g of millet jelly, and 3m1 of peppermint. Then following the steps of lauding, exrra~ing, rolling, cutting into 3g /piece product, and finally products are packed Example 81, Blending in foods {mineral containing lactic acid drinks) The formulation comprises Ikg of skim milk, l.5kg of sugar,15g of lactic acid, 5g of calcium lactate, and 4g of pcvpylene glycol alginate. Skim milk is heated to 50°C when sugar is dissolved. Then calcium lactate and propylene glycol alginate are added and to keep at $0°C for 20 minutes. After sterilizing, the solution is filtered and cooled down to 15°C. The lactic acid is mixed with 75m1 of boiled water and added to the filtered skim milk solution in srising, and finally z6 bottled to Obtain product.
Example 82, Blending in foods (peanut products) The formulation ises 1 kg of peanut, 20g of salt, 25g of fi~aric acid, 50g of lecidvn, 20 mg of pineapple enzyme and 2 ml of ethanol. The peanut is znastad at 160°C for 1 hour and ground into powder after drying, and sieved to remove the skins and germs. To add salt, lecithin, Pineapple enzyme (which is dissolved in alcohol first), and fumaric acid consequently, and is ground to fcxrn paste before packing in a 500 g bottle.
Example 83, Ble~ing in foods {puddings) The formulation comprises 750m1 of milk, b pieces of egg, I50 g of sugar, 21 g of suocinic acid, 2 dcnps of ethyl iso-val~ianate, and caramel raw maul (100 g of sugar and 6 g of water) for 10 pieces puddings. The process is: making cat~nel by heating the mixture of sugar and water in flat pan; the caramel is divided into 10 ponivns for vessels which the bottoms have robbed. with few amount of oil;
heating the mixture of milk and perfume to near boiling by steam; mixture of egg and sugar is bubbled and added to the milk mixture; mixing the resulted mixture; then is filled into the vessels canefuJly; and steamed at 160°C for 30 minutes to form the Example 84, Orange juice drinks The formulation comprises 5 kg of orange juice (sweetness 10° and acidity 1.0%), 0.95 kg of anhydrous fii~ose,1 ml of age essence, and 150 g of citric acid. The production method is to mix the dissolved materials, and pure water is added to make up 101 of orange juice and packed.
Example 85. Soh orange drinks 'Ihe formulation comprises 5 kg of orange juice (sweetness 50°, acidity 6°Io),1.2 kg sugar, 200g of malic acid, 5 ml of orange essence, and boiled water to make up 10 L The you process is mixing the materials homogenously, this mixture is botxled, and finally carbon dioxide gas is induced.
Example 86~-95, Ihugs made of fruits Fruits which contains at least 0.3% of the effective oomponetit of this invention, such as acidic orangc, lemon, plum, fruit orange, grape, apple, cnbola, strawberry, and pineapple are processed to produced cans by normal method inclluding. selecting, clearing, removing stalks, aiming )»ads and tails, skin and core removing, buds removing, slicing, tanning, weighing, synip adding, sterilizing, cooling, inspection, and packing.
The former examples use pure d~ic~ls as effective component. Now, to use acid contained fntits replace the pure chemicals in these examples. For the low acid contained fruits, the juice must be concentrated to in~ease the acids level, and then to take the place of pure chemicals in these exa~les.
Taking example 84, for instance, the juice is oompoW with Skg of orange juice containing acidity I .0 % and 150 g of citric acid. There is 2008 of citric acid in a I O i of orange juice thinks. How much quantity of Emits is needed when producing the same 101 juice with different levels of citric acid containing, the results are shown as table 6.
Table 6. The equivalent dose of effearve compcment in usin;~ fruits ExampleEmit At.~idity,Zhe amount notation % of fruit equivalent to 200g civic acid, Iq;

86 Orange 6.0 333 (1) 87 Orange 4.0 5 (2) 88 Lemon 7.0 2.58 89 Plum I3.8 5.2 90 Grape 2.0 10 fivit 91 Grape 1.0 20 Needed conoentsation 92 Apple 0.5 40 Needed correntration 93 Carambois5.0 4 94 Straw 0.8 25 Needed cor~cenh~tion berry 95 Pineapple 4.5 4.4 Fxamples of 91, 92 and 94 have volume mare than 101, they are needed to concentrate nn order to get their acidity greater than 1Ø
The edible organic acids are the effective component of this invention, so that to use the organic acid contained fruits are reasonable. The other compounds of fruits are not important just as pharmaceutical acceptable carriers.
Example 96, Fruits (lemon) The forrrnilation cximprises 1 kg of lemons (acidity 6%), 0.5 kg of sugar, 0.3 kg of honey, l g of glyCyr~iz~ paste, 0.2 g of salt, and the final product is 1.6 kg.
Lxmons are processed by steps of selecting, peeling, cleaning, slicarg, bottling in half volume, and mixing vigorously and adding the otl~ rrraterials. The product is steri);zed by heating and cooling after sealing, ar without heating treatment Example 97, Fruits (caramhola) The formulation comprises 1 kg of carambola (acidity 5%), OS kg of sugar, 0.3kg of honey, l g of glycyrrhizin paste and 0.2 g of salt.
Carambolas are proud with selecting, cleaning, cutting head and tail, slicing into size of 3/4 inch, bottling in half volume, and mixing vigorously and adding the other materials. The product is sterilized by heating ana cooling after sealing, or without heating ant.
Example 98, coffee (instant coffee and packed coffee solution) The f~on comprises 10 kg of coffee bean,1.5 kg of maiic acid, 9.6 kg of sugar, 7.2 kg of cream, aril water far balance.
Coffee beans are roasted, ground and heat water extra under pressure, and a 30% coffee of 10 I solution is obtained. The malic acid is added into the resulted solution. The solution is concentrated by the frozen method and frozen dried under nitrogen gas. A4.5 kg of instant coffee product containing 33% of malic acid is produced.
That coffee product is further eon with 9.6kg of sugar and 7.2kg of cream, and packed in a 17g content product of carry-pack instant coffee.
A kind of liquid coffee drinks are made from the 30% mffee contained solution.

That is oo~r~pounding with LSkg of malic acid, 9.~cg of sugar, 7.Zkg of cream arxi the balance of water to make up of 240 liters. After heating and cooling, to pack in a volume of 200 ml, then 1200 packs of liquid coffee are produced.
Example 99, Apple ciders The fom~ulation comprises 1.4 kg of sugar, 40g of malic acid, 4g of ethyl iso-valerate, 20 mg of vitamin B 1, and the bala~e of water to make up 10 L
The ~ is made to a 56%a solution fist Zhe rest components am dissolved in wale; and then mixed with sugar solution. The resulted solution is subject to filtration, cooling, contacting with carbon dioxide gas under high pressure, and packed to form apple cider which has a bottle pressure of 50 1b at 15°C.
Fxatnple 100, sarsaparillas The formulation comprises 100 ml of sarsaparilla extrra~ct, 24 ml of alcohol, 500 g of sugar, 3908 of fivctose, S.Sg of phosphonis pentaoxide, I0g of cacnmel, l ml of vanillin,100g of citric acid and water to make up 101.
The perfume is dissolved in alcohol fu~t and then mixed with sarsaparilla extract, and dissolved with other components in pure water to form 101 of solution.
This solution is packed in bottles as making ciders, and contacting with carbon dioxide gas to produce the products.
Example 101, Cola drinks The formulation comprises 100 ml of cola seed extract, 24 ml of alcohol, 500g of sugar, 390g of frnctase, SSg of phosphorus pentaoxide, log of caramel, l ml of vanilla essence,1.4g of caffeine,100g of citric acid and balance of water to make up to 10 L The producing process is as die same of ciders.
Example 102, Fermented milk drinks The formulation comprises 101 of skim milk, 2 kg of skim mild powder, 5 kg of millet jelly, 3 kg of sugar,100g of CMC, 50g of citric acid, log of phosphoric acid, I80 ml of lactobacillus bulgaricus, argi 1 ml of vanillin essence.
Skim mills and skim milk powder are mixed, then heated up to 80°C
for 30 minutes for sterili?.ing. L,acGobacillus bulgaricus is added when solution cooling to 40 °G, and f~ented at 38°C for 20 hours. When the acidity is reaching at 1.4%
mixed hardly The mixture is heated to 60°Cand dispersed die solid conic by homogenizer, and sugar, millet jelly and phosphoric acid are added during heating.
The mixture is heated up to 80°C for 20 minutes for sterilizing, and filtered at hot.
After cooling, the pafmne in alcohol is added, and bottled and sealed to form produc.
If the ferrrlented pmduc~s are not heated, perfume is added directly aft filtration and paddng, a lactobacillus bulgaricus contair~d drinks could be obtained (functional drinks}.
E~mple 103, Beers The farrrnulation comprises 101 of Taiwan beer, made by Taiwan Beer Co., having 1.0075 of specific gravity, 3.4 % of extract contained, pId4.2, acidity 1.3, and 45 g of citric acid and 25 g of potassium d~hy~dnogen citzate.
The product is produced by mixing the materials and to make up carbo3n dioxide gas before capping.
Example 1(k1, Fruit wines The fo~mularion irises 1.5 kg of lemon, 300g of garlic, 50g of zinger, 200g of fiuctose, 21 of rice wine, and 300g of honey The process is to set the following materia)s: the peeled and sliced lemon;
garlic which is peeled and heated in microwave for 1 minute and cooled; sliced zingers;
honey; and rice wine; into a container in order, and sealed for one month.
Example 105, Other wines such as whisky rice wine, brandy, sake, sorghum wine, and grape wine.
All wines contain diffaerlt amounts of organic acid that is formed dicing fermentation, suctl as grape wine (0.53%~ sorghum wine (0.0550.07%}, rice wine (0.4-y0.6%}, and sake (0.15%}. The proper dose of this invention is acidity in a range of 2~3°l0, so that to adjust wines by adding additional amount of acid to meet this range.
Example 106, Herb wines The formulation comprises 20g of herbs (including 0.5g of Wujapi,1.9g of cinnam~o~n,1.5g of Angelica, 5g ofYchu, 0.4g of Paidansin, 0.7g of Ghunachung, 0.7g glycyrrhizin,1.5g of Huwuso, C~uanneudii, 7.5g of Souti), 3.07 I of alcohol, 21 Sg of caramel, 4008 of wheat gluten, 400g of sugar, 380g citric acid, I g of isoamyl butyrate, and to make up 101 with pure water All the herb materials except Yichu and Souti are Qushed and mixed, bagged, ad and leached in aloohd for two weeks. Yichu and Souti are chopped and cooked with water heating in a steam jacked pot for 8 hours. Sugar and wheat gluten are dissolved in boiling water, and mixed with the former herb's extract solution and the steam-heated one. To which alcohol is added to adjust to 25% aloohd containing, and then to add pigment and perfume. The resulted compound is set for one week and offer sediment it is stored, packaged and finally to foam product.
Example 107~ll 1, T"tncxure and treat'znent far inflammation, analgesic and itchy The formulation comprises 14g of citric acid, 5g of glycerin, and 90 ml of alcohd (7Qv/v) in a mixture.
A series of testing are carried out by a gcvup of five patients for each syndromes, which treating the topical disease three times a day, the results is shown as table 7.
Table 7 , Results of treating inflammation, analgesic and itchy F~campieDiseases Treating results 107 Acne.(pain) One day scaled, pain improved 108 Insect bite Itchy disappeared in half (itchy, hour, inflammation inflammation,disappeared after 3 hours, pain) and pain unproved 109 Piuigo(itchy)One day improved 110 Skin wound(pain)After dried the wound released, pain unproved, heating quidclY

111 Pustules (pain)The pustules shrink one day, scaled after 2 days, pain irr~OVed Example 112, Improving the allergic risk of dairy prod~uxs The formulation comprises 101 of milk,10 g of citric acid and 3 g of Ca-CMC.
Ihtring mixing milk, Ca-CMC is added in homogenous and then citric acid is added to prnduce a none-allergic dairy milk. 'Ihe pindttd may be produced into milk powder by spray-drying machine.
Example 113, shtirr~ps pnoc~.sing The formulation comprises 10 kg of litter shrimps, 360 g of salt, 360 g of citric acid, and 201 of water.
The s>ni~s are set in a basket and washed in a following water to remove sand.
The washed ~ are ttna~ in a 2(? 1 boiling water, containing salt and citric acid, for 25 minutes. The boded shrimps are sun~ying on straw mats out door.
The dried shrimps are packed in 250 g. The treated products are good for reserving and allergy risk free for allergic persons.
Example 114, Salt fish(little sanline) 'The fon co~tises 10 kg of little sardine,1.2 kg of salt, l kg of citric acid, and 201 of water.
The sardines are washed in a trough and spread on a ten-layer boiling cage, and then heated in a volume of 201 boiling solution in kettle, containing salt and citric acid, for a period of time until the solution boiling again. Before products are removed from the kettle, the upper layer oily floats are washed away by adding new solution. The boiled fishes are sun-died with the cage taming the other side ever day In s<>mmer day, they can be dried in about 3 days.
Example 115, Salt fish(sardine) The forn~ulatlon comprises 10 kg of sat~dine,1 kg of salt, 400 g of malic acid, and 6 liters of water: The fresh sardines are washed with water, and dipped in a solution of 6 liters of water, containing the salt and malic acid, for $
hours.
The dipped fishes are sun dried to become pmducx.
Example 116, Shrimp meat can The formulation comprises 2 kg of King-shrimps, 50 g of salt, and 100 g of malefic acid. The shrimp meat is boiled in 1.5 liters of solution, containing salt and acid, and left the shrimp when that is turned into white color. After canming, sealing, sterilizing under pze5sune, cooling, and inspecting, products are obtained.
Example 117, egg pmdud (crab dish with s«ocinic acid) .
The formulation co~rises half can of cad crab, IO ml of rice wine, 6 pieces of egg, 3 g of salt, l g of nxsnosodium glutami~s,15 g of peanut oil, 5 g of green pea, being for four dishes. The crab meat is compour~d with wine, egg, succinic acid, salt and MSCz Heating 15 g of peanut oil in a pan when a fume is forrning, the compound and green peas are added and frizzled to a medium done. Turning the other side and fizzling for a while, a caab dish with succinic acid is made.
Example 118, ash can containing tow kinds of active agent(citric acid and Nisin) In example 76, the 75 g of tomato paste is mixed with IO mg of Nisin first and then the can is sealed and sterilized by normal pc~ss to form a pmdud.
Example 119. Release of drugs too skin The formulation comprises : A, basic composition: 47%a of a C4 to C8 acrylic acid-iso borneol copolymer and 53% of a mixture (containing 96% of 2-ethylliexy acrylate, and 4 ale of n-vinyl-2-pyrrolidone), u~d 5% of ~sliuking agent of 2-(4-(2 hydroxy 2-methyl-1-oxopropyl) phen~oxyethyl} 2- propioa~ate;
B, composition of release of drugs to skin: 0.9g of pepp~mint,1.2g of peppermint oil, 0.8g of camphor, 1.2g of citric acid, and 1008 of the A compound.
The compound is coated on a treated paper radiation wig 300wrmch of W for 1 minute to form a pie sensitive release of drug to the skin.
The products are given five patients who are used to allergic reactions when using adhesives in transdermal drug delivery systems, to use continuously for many days. The results show that here is no any allergic reaction or achy happened.
Besides, the effect of release of drug to the skin is better than the normal product Example 120, Production of allergy free medical groove.
The formulation aorr~xises 200 parts of natural rubber latex ( pH105, amtaining ammonia, solid component 50 %,'Izaiping Petalc, Malaysia), 75 parts of boric acid treated casein (solid component 10 %),10.0 parts of zinc oxide dispersion solution ( solid component 50%),133 parts of corn starch slung crossing treated by epichlorohydiin {solid component 50%),1 part of sulfur powder, 0.05 parts of carboxyl polymethylene polyrr>er (molecule weight 500,001,000,000}, the rr~st is deionized water to dilute to form a 10% solid containing. The coaoervation agent is 45% calcium nitrate in deionized water.
The production is ao~ding to the conventional method hand rrrodel dipping into latex solution, drying, dipping into latex solution, drying, dipping into latex solution, drying, folding edge, drying, crosslinldng meatlnent, washing, drying, dipping into 5% citric acid solution,, drying , powdering (5~4t~.t Mg0), removing from model, aril finally, packing for product.
If do not us dipping with liquid solution of the effective ag~t of present invention, the effective agent could be pulverized to form a sized of 5~40Nand mixing with Mg0 in a rate of 4% for powdering. Testing is carried out for five medical persons who have allergic reactions tn latex grove. The results shown none had the alleagic ruction.
Example 121, Agent for head scale (hair lotion}
The forrrnrlaticrr comprises 1.2% of peppermint oil, 6% of glycerin, 0.2% of chlorophyll, 2% of malic acid, 60% of alcohol and 30.6% of distill water:
Testing is out by five male patients, rubbing the lotion twice a day after washing hair.
They all improved that their head soles and achy problems.
Example 122, Glucose injection (containing other active agent) To dissolve 500 g of glucose and 10 g of citric acid in 101 of high pressure sterilized water in a clean room. The solution is filtered by ceramic filter and packing into a 500 ml injection product by the GMP method.
Exarrrple 123, Testing for anti-free radicals The determination of free radical content is perfam~ed by using individual fire radical testing kit, of BioVitale Inc. (Irvine, La., USA). The pmcess is as follows:

to take the specific amount of urine by pipette, open the testing agent ampoule and adding the urine, shaking the ampoule for 5 minutes, comparing the color of ampoule solution with these oolaas listed in table of kit. The table of flee radical content level is divided into 4 classes: most propea~ level (0), low level (+1), medium level (+2), and high level (+3).
'Ihe volunteers selected 5 persons. In the group, 2 persons have medium fi~ee radical levels in urine, and the rest are high levels. They are given the agent as shown in example 51 three times a day individual, and sampling the urines 2 day after The results are shown in Table 8. The effective agent of this invention shows good in anti-free radical.
Table 8, fi~ee radical content in urine Item Free radical Free radical content oont~ent in in urine before urine after administrated testing the drug of this invention Person 1 +2 0 Person 2 +2 0 Person 3 +3 0 Person 4 +3 0 Person 5 +3 0 Example 124129, Testing for the dep~nession of enzyme activity We recognized that the effective agent of present invention shows the ability of ts~ating histamine, inflammation, analgesic, and achy from examples of 145 and 107 111. It goes without saying that they also could depression the cascade of the produaron of prostaglandins and other chemicals. Therefore, there are not any embolus and thrombus to be happened, and could avoid cardiovascular diseases such as congestion of the brain anri myocardial infarction. The first step of formation for a clot is that the releasing of thromboxane from platelet induces the message of enhancing coagulation. The free radical of peroxide is a major factor for activating cyclooxygenase in prostaglandin cascade. It is clear from the testing results of exa~le 123, when the dnrg of this invention existing, that cascade could not be happened, because the free radical is inhibited by the drug of this invention.
The production process of peroxide free tactical can be tested by Xanthine oxidase substrate in vito (Fridowich, L, J. Biol. Chem, 2I S, 40534057,1970).
This method is applied Oo prove the efr'ect of this invention. The test of inh~iting xanthine oxidase is out by the method of H. M. Kalckar (J. Biol. Chem,167, 429~443,19~47). The basic principle is xanthine being acted by xanthine oxidase to fomn uric acid that is quantitative analyzed by photometric method. By the amount of dete<micied uric acid, is calculated the degree of inhibiting effect for the activity of xanthine oxidase.
The testing process is, adding a final concentration of 0.01 u/ml of xanthine oxidase in 1 cm cell of photometric apparatus, and adding 0.05M (pH=7.4) of phosphoric acid buffs oar inhabitant. The reaction time is oatated &nm the point at adding xanthene's to a final concentration reac~ng 5x10'SM. For reducing the ~ arose by absorption of liquid in photomelric analysis, the compound of xanthine oxidase, xanthine and drug are boiled for the mfet~ence. UV selected at 295nm, data are rat an interval of 30 seconds for 2 minutes. The unit of activity change of xanthine oxidase is O.OO1M/min. Cala>late the inhibiting rate for each addition amounk of drug. To use the dnrg concentration (11~ as a function of inhibiting rate (%), and to trace the data on a log scale paper, the 50%
depression rate of the oxidase (ICso} could be determined by regression line method.
The dnigs tested are succinic acid, citric acid, maiic acid, tartaric acid and furnaric acid, and using folic acid for comparison. The results are listed as table 9.
The dings of this invention show high inhibition effect.
Table 9, Testing results for ICso ExampleDrug ICso (concentration for depression of 50%

activity of oxidase) 12r1 Succlnic acid I25 Citric acid 1.18 x 10~' M

126 Malic acid ' 1.00 x 10-' M

12 Tartaric 7 acid 128 Fumaric acid 129 Folic acid 1.12 x 10''M
1.02 X 10-' M
1.01 x i0' M
6.b2 X 10-' M
F~ample 130--135, Testing for analgesic 'Ihe formulation of dnig for testing comprises 300 mg of malic acid, 300 mg of c acid, 300 mg of ci~ir acid, 50 ms of csff~:r~ ~d 10 mg of cabedzin. Fn~e volunteers of head-ache and physical pain ace given one dose individual. To reccmd the reaction after treatment, they all felt their pains are improved in minutes.
What is daimea is:
1. A drug composition containing the effective components of edible acid andl or acidic salt and any pharmaceutical acceptable compound to lower ~e humor pH
and treating or alleviating immure diseases.
3s

Claims (54)

1. A drug composition containing the effective components of edible acid and/or acidic salt and any pharmaceutically acceptable compound to lower the humor pH
and treating or alleviating immune diseases.

2. A drug composition according to claim 1 wherein said edible acid and/
or acidic salt is a compound such as phosphoric acid, sodium dihydrogen phosphate, potassium dihydrogen phosphate, sodium hydrogen phosphate, potassium hydrogen phosphate.

3. A drug composition according to claim 1 wherein said edible acid and/
or acidic salt is a compound such as fumaric acid, succinic acid, malic acid, tartaric acid, citric acid, lactic acid, .alpha.-hydroxy ethanic acid, .alpha.-octanoic acid, gluconolactone, acetic acid, propanoic acid, ascorbic acid, sodium dihydrogen citrate, sodium hydrogen citrate, potassium dihydrogen citrate, potassium hydrogen citrate, sodium hydrogen succinate, potassium hydrogen succinate, sodium hydrogen tartrate, potassium hydrogen tartrate, sodium hydrogen malate, potassium hydrogen malate, sodium hydrogen fumarate, potassium hydrogen fumarate, and their compounds.

4. A drug composition according to claim 1 wherein said immune diseases is selected from the group comprising hypersensitivity, immunodeficiency, autoimmunity and tumor.

5. A drug composition according to claim 1 wherein said edible acid and/
or acidic salt concentration is 0.06~100(wt/wt) %, prefer is 0.1~100(wt/wt) %, better is 0.2~100(wt/wt)%, and the best is 0.3~100(wt/wt)%.

6. A drug composition according to claim 1 wherein said drug is selected from group comprising oral agent, non-oral agent, or topical usage.

7. A drug composition according to claim 1 wherein said drug is oral agent selected from the group comprising capsule, tablet, flake, granule, powder, pile, lozenges, syrup, beverages, solution, suspension liquid, and blending in food.

8. A drug composition according to claim 1 wherein said drug is oral agent compounding with food selected from the group comprising biscuits, cake, candy, chew gum, canned foods, diary product, peanut product, pudding, egg product, cooking dishes.

9. A drug composition according to claim 1 wherein said drug is oral agent compounding with food selected from the group comprising juice, wine, (such as fruit wine, whisky, brandy, sake, beer, and herb wine) soft drink, carbonated drink, none carbonated drink, tea, sports drink, functional drink, coffee, cola, sarsaparilla, diary product such as fermented milk, and herb drink.

10. A drug composition according to claim 9 wherein said drug is fermented milk product.

11. A drug composition according to claim 1 wherein said edible acid and/or acidic salt is a fruit containing edible acid and/or acidic salt more than 0.3(wt/wt)% selected from the group comprising acidic orange, lemon, plum, fruit orange, grape, apple, carambola, strawberry, and pineapple.

12. A drug composition according to claim 1 wherein said edible acid and/or acidic salt is in a form of processed fruit selected from the group comprising acidic orange, lemon, plum, fruit orange, grape, apple, carambola, strawberry, and pineapple containing edible acid and/or acidic salt more than 0.06(wt/wt)%, prefer more than 0.3(wt/wt)%.

13. A drug composition according to claim 1 wherein said drug is an oral agent, compounding with compounds selected from group comprising: binder agent, such as corn starch, glycine, polyethylene, pyrrolidone, Ca-CMC, CMC, gelatin, Arabic gum, and tragacanth gum; gelatin, acacia gum and tragacanth gum; densifier; such as propylene glycol alginate; softener such as D.B.P.; disperser such as calcium carbonate, polyethylene glycol, stearic alcohol, fluid paraffin; emulsifier such as Span-60; preservative, such as ethyl para-hydroxy benzoate; lubricating agent such as magnesium stearate, talc powder, enzyme, such as papain, bromelin and ficin; sweetener agent such as sugar, lactose, glucose, black sugar, syrup, honey, fructose, maltose, lactose, oligomer; perfume agent, such as peppermint, peppermint oil, essential oil, green oil, strawberry essential oil, ethyl iso-valerate, iso amyl butyrate, cocoextracte; pigment such as caramel; herb, such herb such as gambir, garlic, leek, chive, shallot, ramson, scallion, zinger, tang-kuei, licorice, astragali radix, armeniacae semen, fritillaria cirrhosae bulbous, atractylodis rhizoma, pinelliae tuber, angelica sinensis radix, hoelen, asini gelatinum, citri sinensis exocarpium, asparagi radix, rehmanniae radix et rhizoma, perillae fructus, perillae caulis, anemarrhenae rhizoma, albae sinapis semen, mori radicis cortex, zingiberis siccatulm rhizoama, lily bulbous, sesame, ginseng, coffee or caffeine, tea, in powder or extracts; another nutrient, such as mineral, vitamin, diary products, peanut product and their compounds.

14. A drug composition according to claim 1 wherein said drug is injection selected from the group comprising intradermal injection, muscles injection, venous injection hypodermic injection, the join lubricating liquid, intestine and in tumor.

15. A drug composition according to claim 1 wherein said drug is inhalants.

16. A drug composition according to claim 1 wherein said drug is none oral agents such as liquid, paste, aero sol, spray and skin absorption;
in which the solvent is selected from the group comprising water, alcohol.

17. A drug composition according to claim 1 wherein said drug is tincture for treating topical wounds.

18. A drug composition according to claim 1 wherein said drug is cold drug.

19. A drug composition according to claim 1 wherein said drug is drug treating insect bite.

20. A drug composition according to claim 1 wherein said drug contains another effective compound.

21. The use of a drug composition containing the effective components of edible acid and/or acidic salt and any pharmaceutical acceptable compound to lower the humor pH value and treating or alleviating immune diseases.

22. The use of a drug composition according to claim 21 wherein said edible acid and/or acidic salt is such as fumaric acid, succinic acid, malic acid, tartaric acid, citric acid, lactic acid, .alpha.-hydroxy ethanic acid, .alpha.-octanoic acid, gluconolactone, acetic acid, propanoic acid, ascorbic acid, sodium dihydrogen citrate, sodium hydrogen citrate, potassium dihydrogen citrate, potassium hydrogen citrate, sodium hydrogen succinate, potassium hydrogen succinate, sodium hydrogen tartrate, potassium hydrogen tartrate, sodium hydrogen malate, potassium hydrogen malate, sodium hydrogen fumarate, potassium hydrogen fumarate, and their compounds.

23. The use of a drug composition according to claim 21 wherein said edible acid and/or acidic salt is such as phosphoric acid, sodium dihydrogen phosphate, potassium dihydrogen phosphate, sodium hydrogen phosphate, potassium hydrogen phosphate.

24. The use of a drug composition according to claim 22 wherein said edible acid and/or acidic salt is acidic fruits, such as acidic orange, lemon, plum, fruit orange, grape, apple, carambola, strawberry, and pineapple.

25. The use of a drug composition containing the effective components of edible acid and/or acidic salt and any pharmaceutical acceptable compound to lower the humor pH value and to improve individual immunity is used in foods, drink, and health care products.

26. The use of a drug composition according to claim 25 wherein said edible acid and/or acidic salt is a compound such as fumaric acid, succinic acid, malic acid, tartaric acid, citric acid, lactic acid, .alpha.-hydroxy ethanic acid, .alpha.-octanoic acid, gluconolactone, acetic acid, propanoic acid, ascorbic acid, sodium dihydrogen citrate, sodium hydrogen citrate, potassium dihydrogen citrate, potassium hydrogen citrate, sodium hydrogen succinate, potassium hydrogen succinate, sodium hydrogen tartrate, potassium hydrogen tartrate, sodium hydrogen malate, potassium hydrogen malate, sodium hydrogen fumarate, potassium hydrogen fumarate, and their compounds.

27. The use of a drug composition according to claim 25 wherein said edible acid and/or acidic salt is a compound such as phosphoric acid, sodium dihydrogen phosphate, potassium dihydrogen phosphate, sodium hydrogen phosphate, potassium hydrogen phosphate.

28. The use of a drug composition according to claim 25 wherein said edible acid and/or acidic salt is an acidic fruit selected from the group comprising acidic orange, lemon, plum, fruit orange, grape, apple, carambola, strawberry, and pineapple.

29. The use of a drug composition according to claim 25 wherein said foods is oral agent compounding with food selected from the group comprising cake, biscuits, candy, chew gum, canned foods, diary products, peanut products, pudding, egg products, cooking dishes.

30. The use of a drug composition according to claim 25 wherein said drink is selected from the group comprising juice; wine, such as fruit wine, whisky, brandy, sake, beer and herb wine; soft drink, carbonated drink, none carbonated drink, tea, sports drink, functional drink, coffee, cola, sarsaparilla, diary product such as fermented milk, and herb drink.

31. A method of preparing denature food comprises treating the said food with edible acid and/or acidic salt solution.

32. The method according to claim 31 wherein said denature food is milk or milk powder.

33. A method of preparing lowering allergic food comprises treating the said food with edible acid and/or acidic salt solution.

34. The method according to claim 33 wherein the said food is selected from the group comprising fish, shrimp, crab, milk, or powder milk.

35. The method according to claim 33 wherein the said edible acid and/or acidic salt is a compound such as fumaric acid, succinic acid, malic acid, tartaric acid, citric acid, lactic acid, .alpha.-hydroxy ethanic acid, .alpha.-octanoic acid, gluconolactone, acetic acid, propanoic acid, ascorbic acid, sodium dihydrogen citrate, sodium hydrogen citrate, potassium dihydrogen citrate, potassium hydrogen citrate, sodium hydrogen succinate, potassium hydrogen succinate, sodium hydrogen tartarate, potassium hydrogen tartarate, sodium hydrogen malate, potassium hydrogen malate, sodium hydrogen fumarate, potassium hydrogen fumarate, and their compounds.

36. The method according to claim 33 wherein the said edible acid and/
or acidic salt is a compound such as phosphoric acid, sodium dihydrogen phosphate, potassium dihydrogen phosphate, sodium hydrogen phosphate, potassium hydrogen phosphate.

37. The method according to claim 33 wherein the concentration of said edible acid and/or acidic salt is 0.06~10(wt/wt)% , prefer is 0.1~7(wt/wt)%, better is 0.2~4(wt/wt)%, best is 0.32(wt/wt)%.

38. The products of any claims as claimed 31 - 37.

39. A kind of food, drink or health care product, which contains edible acid and/
or acidic salt, for lowering the humor pH value and improving individual immunity.

40. A kind of food, drink or health cane product according to claim 39 wherein said edible acid and/or acidic salt is such as fumaric acid, succinic acid, malic acid, tartaric acid, citric acid, lactic acid, .alpha.-hydroxy ethanic acid, .alpha.-octanoic acid, gluconolactone, acetic acid, propanoic acid, ascorbic acid, sodium dihydrogen citrate, sodium hydrogen citrate, potassium dihydrogen citrate, potassium hydrogen citrate, sodium hydrogen succinate, potassium hydrogen succinate, sodium hydrogen tartrate, potassium hydrogen tartrate, sodium hydrogen malate, potassium hydrogen malate, sodium hydrogen fumarate, potassium hydrogen fumarate, and their compounds.

41. A kind of food, drink or health care product according to claim 39 wherein said edible acid and/or acidic salt is such as phosphoric acid, sodium dihydrogen phosphate, potassium dihydrogen phosphate, sodium hydrogen phosphate, potassium hydrogen phosphate.

42. A kind of food, drink or health care product according to claim 39 wherein said edible acid and/or acidic salt concentration is 0.06~10(wt/wt) %, prefer is 0.1~7(wt/wt)%, better is 0.2~4(wt/wt)%, and the best is 0.3~2(wt/wt)%.

43. A drug composition according to claim 1 wherein said drug is an anti-inflammatory drug.

44. A drug composition according to claim 1 wherein said drug is bath agent.

45. A drug composition according to claim 1 wherein said drug is an agent for treating head scale.

46. A drug composition according to claim 1 wherein said drug is an agent for treating goods contacting skin.

47. A drug composition according to claim 1 wherein said drug is an agent releasing drug from skin.

48. A drug composition according to claim 1 wherein said drug is an agent for treating thrombus.

49. A drug composition according to claim 1 wherein said drug is an agent for free radical scavenger.

50. A drug composition according to claim 1 wherein said drug is for spondyle animal, prefer is for mammal, and the best is for human.

51. A method for producing allergy free clothing that is treated with edible acid and/or acidic salt.

52. A method for allergy free clothing according to claim 51 the said clothing is groove or clothes.

53. Clothing such as groove or clothes is treated by method according claim 51.

54. A method that uses the effective components of edible acid and/or acidic salt to lower the humor pH and to treat or to alleviate immune disease.