CA2529244C - Lymphocytes t resistant a la rapamycine et leurs utilisations therapeutiques - Google Patents
Lymphocytes t resistant a la rapamycine et leurs utilisations therapeutiques Download PDFInfo
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- CA2529244C CA2529244C CA2529244A CA2529244A CA2529244C CA 2529244 C CA2529244 C CA 2529244C CA 2529244 A CA2529244 A CA 2529244A CA 2529244 A CA2529244 A CA 2529244A CA 2529244 C CA2529244 C CA 2529244C
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- cells
- rapamycin
- cell
- gvhd
- carcinoma
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
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- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46434—Antigens related to induction of tolerance to non-self
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- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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Abstract
L'invention concerne des méthodes de génération de fonctions Th1/Tc1 et Th2/Tc2 hautement enrichies. En particulier, la génération de ces fonctions est obtenue par l'addition d'un médicament immunodépresseur, la rapamycine ou un composé dérivé de rapamycine. En plus d'une pureté accrue de la fonction lymphocytes T, les lymphocytes T générés dans la rapamycine expriment également des molécules améliorant la fonction lymphocytes T immune telle que CD28 et CD62L. Lesdits sous-ensembles de lymphocytes T fonctionnels générés par rapamycine peuvent avoir une application dans la prévention ou dans le traitement de la réaction de greffe contre hôte GVHD après transplantation de cellules souches hématopoïétiques allogéniques, le traitement de l'auto-immunité ou la thérapie d'infections ou du cancer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US47873603P | 2003-06-12 | 2003-06-12 | |
US60/478,736 | 2003-06-12 | ||
PCT/US2004/018609 WO2005003335A2 (fr) | 2003-06-12 | 2004-06-10 | Lymphocytes t resistant a la rapamycine et leurs utilisations therapeutiques |
Publications (2)
Publication Number | Publication Date |
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CA2529244A1 CA2529244A1 (fr) | 2005-01-13 |
CA2529244C true CA2529244C (fr) | 2014-02-18 |
Family
ID=33563779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA2529244A Expired - Lifetime CA2529244C (fr) | 2003-06-12 | 2004-06-10 | Lymphocytes t resistant a la rapamycine et leurs utilisations therapeutiques |
Country Status (2)
Country | Link |
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CA (1) | CA2529244C (fr) |
WO (1) | WO2005003335A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0503936D0 (en) * | 2005-02-25 | 2005-04-06 | San Raffaele Centro Fond | Method |
GB0603081D0 (en) * | 2006-02-15 | 2006-03-29 | Dynal Biotech Asa Oslo | Method |
WO2010083298A1 (fr) * | 2009-01-14 | 2010-07-22 | Health Research Inc. | Procédés et compositions contenant des inhibiteurs de la mtor pour améliorer les réponses immunitaires |
CN111454903B (zh) * | 2020-05-06 | 2023-10-20 | 青岛瑞思德生物科技有限公司 | 免疫细胞体外培养、诱导、激活、冻存方法及其细胞库建立 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003038062A2 (fr) * | 2001-10-31 | 2003-05-08 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Generation et utilisation de cellules tc1 et tc2 |
WO2003004625A1 (fr) * | 2001-07-02 | 2003-01-16 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Methodes de generation de cellules humaines th2 cd4+ et utilisations associees |
-
2004
- 2004-06-10 CA CA2529244A patent/CA2529244C/fr not_active Expired - Lifetime
- 2004-06-10 WO PCT/US2004/018609 patent/WO2005003335A2/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2005003335A2 (fr) | 2005-01-13 |
WO2005003335A3 (fr) | 2005-06-09 |
CA2529244A1 (fr) | 2005-01-13 |
WO2005003335A9 (fr) | 2005-09-29 |
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