CA2521228A1 - Biphenyl carboxylic amide p38 kinase inhibitors - Google Patents

Biphenyl carboxylic amide p38 kinase inhibitors Download PDF

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Publication number
CA2521228A1
CA2521228A1 CA002521228A CA2521228A CA2521228A1 CA 2521228 A1 CA2521228 A1 CA 2521228A1 CA 002521228 A CA002521228 A CA 002521228A CA 2521228 A CA2521228 A CA 2521228A CA 2521228 A1 CA2521228 A1 CA 2521228A1
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Canada
Prior art keywords
6alkyl
optionally substituted
groups
methyl
hydrogen
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Abandoned
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CA002521228A
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English (en)
French (fr)
Inventor
Nicola Mary Aston
Paul Bamborough
Katherine Louise Jones
Vipulkumar Kantibhai Patel
Stephen Swanson
Ann Louise Walker
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SmithKline Beecham Corp
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Individual
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Publication of CA2521228A1 publication Critical patent/CA2521228A1/en
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    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Neurology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
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  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
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CA002521228A 2003-04-09 2004-04-07 Biphenyl carboxylic amide p38 kinase inhibitors Abandoned CA2521228A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0308186.6A GB0308186D0 (en) 2003-04-09 2003-04-09 Novel compounds
GB0308186.6 2003-04-09
PCT/EP2004/003774 WO2004089874A1 (en) 2003-04-09 2004-04-07 Biphenyl carboxylic amide p38 kinase inhibitors

Publications (1)

Publication Number Publication Date
CA2521228A1 true CA2521228A1 (en) 2004-10-21

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CA002521228A Abandoned CA2521228A1 (en) 2003-04-09 2004-04-07 Biphenyl carboxylic amide p38 kinase inhibitors

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US (1) US7572790B2 (US07652168-20100126-C00055.png)
EP (1) EP1608616A1 (US07652168-20100126-C00055.png)
JP (1) JP2006523194A (US07652168-20100126-C00055.png)
AU (1) AU2004228199A1 (US07652168-20100126-C00055.png)
BR (1) BRPI0408727A (US07652168-20100126-C00055.png)
CA (1) CA2521228A1 (US07652168-20100126-C00055.png)
GB (1) GB0308186D0 (US07652168-20100126-C00055.png)
MX (1) MXPA05010521A (US07652168-20100126-C00055.png)
WO (1) WO2004089874A1 (US07652168-20100126-C00055.png)
ZA (1) ZA200506919B (US07652168-20100126-C00055.png)

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TWI263497B (en) * 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
GB0217757D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Novel compounds
GB0308201D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
ES2315703T3 (es) * 2003-07-25 2009-04-01 Novartis Ag Inhibidores de la quinasa p-38.
GB0318814D0 (en) 2003-08-11 2003-09-10 Smithkline Beecham Corp Novel compounds
GB0402137D0 (en) * 2004-01-30 2004-03-03 Smithkline Beecham Corp Novel compounds
GB0402140D0 (en) * 2004-01-30 2004-03-03 Smithkline Beecham Corp Novel compounds
GB0402143D0 (en) * 2004-01-30 2004-03-03 Smithkline Beecham Corp Novel compounds
CA2574600C (en) * 2004-07-23 2010-08-31 Pfizer Inc. Pyridine derivatives
TW200628153A (en) * 2004-10-05 2006-08-16 Smithkline Beecham Corp Novel compounds
RU2452729C2 (ru) * 2005-09-16 2012-06-10 Арроу Терапьютикс Лимитед Бифенильные производные и их применение при лечении гепатита с
CA2621364A1 (en) * 2005-09-16 2007-03-22 Arrow Therapeutics Limited Biphenyl derivatives and their use in treating hepatitis c
EP2038253A1 (en) * 2006-05-30 2009-03-25 Arrow Therapeutics Limited Biphenyl derivatives and their use in treating hepatitis c
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EP1608616A1 (en) 2005-12-28

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