CA2502363A1 - Solution d'irrigation et methode d'inhibition de l'adhesion de cellules tumorales, de douleurs et d'inflammations - Google Patents

Solution d'irrigation et methode d'inhibition de l'adhesion de cellules tumorales, de douleurs et d'inflammations Download PDF

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Publication number
CA2502363A1
CA2502363A1 CA002502363A CA2502363A CA2502363A1 CA 2502363 A1 CA2502363 A1 CA 2502363A1 CA 002502363 A CA002502363 A CA 002502363A CA 2502363 A CA2502363 A CA 2502363A CA 2502363 A1 CA2502363 A1 CA 2502363A1
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CA
Canada
Prior art keywords
receptor
antagonists
agents
solution
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002502363A
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English (en)
Inventor
Gregory A. Demopulos
Pamela Pierce Palmer
Jeffrey M. Herz
Darrell Tanelian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omeros Corp
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2502363A1 publication Critical patent/CA2502363A1/fr
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/178—Lectin superfamily, e.g. selectins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne une méthode et une solution permettant d'inhiber de manière périopératoire une adhésion de cellules tumorales et une palette de douleurs et de processus inflammatoires au niveau de blessures liées à des interventions chirurgicales générales, notamment des interventions orales/dentaires. La solution comprend, de préférence, au moins un agent anti-adhésion de cellules tumorales et plusieurs agents d'inhibition de douleurs et d'inflammations dans une concentration diluée dans un véhicule physiologique, tel qu'une solution saline ou de Ringer lactée. La solution est appliquée par irrigation continue d'une blessure pendant une intervention chirurgicale aux fins d'inhibition préventive de douleurs et de manière à éviter simultanément des effets secondaires non souhaités associés à l'application orale, intramusculaire, sous-cutanée ou intraveineuse de doses importantes des agents. Une solution préférée permettant d'inhiber l'adhésion de cellules tumorales, des douleurs et des inflammations comprend au moins un agent anti-adhésion de cellules tumorales, un antagoniste de la sérotonine¿2?, un antagoniste de la sérotonine¿3?, un antagoniste de l'histamine, un agoniste de la sérotonine, un inhibiteur de la cyclo-oxygénase, un antagoniste de la neurokinine¿l?, un antagoniste de la neurokinine¿2?, un antagoniste du purinocepteur, un ouvreur des canaux potassiques sensibles à ATP, un antagoniste du canal calcique, un antagoniste de la bradykinine¿l?, un antagoniste de la bradykinine¿2? et un agoniste µ-opioïde.
CA002502363A 2002-11-12 2002-11-12 Solution d'irrigation et methode d'inhibition de l'adhesion de cellules tumorales, de douleurs et d'inflammations Abandoned CA2502363A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/036675 WO2004043479A1 (fr) 2002-11-12 2002-11-12 Solution d'irrigation et methode d'inhibition de l'adhesion de cellules tumorales, de douleurs et d'inflammations

Publications (1)

Publication Number Publication Date
CA2502363A1 true CA2502363A1 (fr) 2004-05-27

Family

ID=32311656

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002502363A Abandoned CA2502363A1 (fr) 2002-11-12 2002-11-12 Solution d'irrigation et methode d'inhibition de l'adhesion de cellules tumorales, de douleurs et d'inflammations

Country Status (6)

Country Link
EP (1) EP1567179A4 (fr)
JP (1) JP2006508961A (fr)
CN (1) CN1694717A (fr)
AU (1) AU2002359404B2 (fr)
CA (1) CA2502363A1 (fr)
WO (1) WO2004043479A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11484564B2 (en) * 2017-10-20 2022-11-01 Otsuka Pharmaceutical Factory, Inc. Adhesion prevention material
CN112955144A (zh) * 2018-09-07 2021-06-11 赫伦治疗有限公司 手术后疼痛治疗
CN113384702A (zh) * 2021-05-20 2021-09-14 温州医科大学附属第一医院 H1组胺受体拮抗剂在制备治疗神经胶质瘤的药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110597A (en) * 1994-08-09 2002-11-10 Micro Tag Temed Ltd Method of marking, verifying and / or identifying an object and an instrument for performing the method
KR970705401A (ko) * 1994-08-30 1997-10-09 사무엘 시몬 에스큘라이 세포활성의 조정용 히알루론산과 그 유도체(hyaluronic acid and derivatives for modulation of cellular activity)
US6492332B1 (en) * 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
BR9509985A (pt) * 1995-12-12 1998-11-03 Omeros Med Sys Inc Solução para irrigação e método para inibição de dor inflamação e esparmo

Also Published As

Publication number Publication date
CN1694717A (zh) 2005-11-09
AU2002359404A1 (en) 2004-06-03
EP1567179A1 (fr) 2005-08-31
EP1567179A4 (fr) 2007-06-27
JP2006508961A (ja) 2006-03-16
WO2004043479A1 (fr) 2004-05-27
AU2002359404B2 (en) 2008-06-05

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FZDE Dead