CA2493673A1 - Method of preparing an intraocular lens for implantation - Google Patents

Method of preparing an intraocular lens for implantation Download PDF

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Publication number
CA2493673A1
CA2493673A1 CA002493673A CA2493673A CA2493673A1 CA 2493673 A1 CA2493673 A1 CA 2493673A1 CA 002493673 A CA002493673 A CA 002493673A CA 2493673 A CA2493673 A CA 2493673A CA 2493673 A1 CA2493673 A1 CA 2493673A1
Authority
CA
Canada
Prior art keywords
inner mold
intraocular lens
optic
mold
posterior
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002493673A
Other languages
French (fr)
Other versions
CA2493673C (en
Inventor
Gholam-Reza Zadno-Azizi
Albert C. Ting
Tuan Anh Nguyen
Valdemar Portney
Hai-Minh Pham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Visiogen Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/207,717 external-priority patent/US20030078657A1/en
Priority claimed from US10/207,718 external-priority patent/US20030078658A1/en
Priority claimed from US10/207,708 external-priority patent/US6884261B2/en
Priority claimed from US10/207,701 external-priority patent/US7198640B2/en
Priority claimed from US10/207,688 external-priority patent/US6818158B2/en
Application filed by Individual filed Critical Individual
Priority to CA2767318A priority Critical patent/CA2767318C/en
Publication of CA2493673A1 publication Critical patent/CA2493673A1/en
Application granted granted Critical
Publication of CA2493673C publication Critical patent/CA2493673C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1629—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing longitudinal position, i.e. along the visual axis when implanted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
    • A61F2/164—Aspheric lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1648—Multipart lenses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D11/00—Producing optical elements, e.g. lenses or prisms
    • B29D11/02—Artificial eyes from organic plastic material
    • B29D11/023—Implants for natural eyes
    • B29D11/026—Comprising more than one lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1601—Lens body having features to facilitate aqueous fluid flow across the intraocular lens, e.g. for pressure equalization or nutrient delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1654—Diffractive lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/16965—Lens includes ultraviolet absorber
    • A61F2002/1699—Additional features not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes
    • A61F2240/002—Designing or making customized prostheses
    • A61F2240/004—Using a positive or negative model, e.g. moulds

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Mechanical Engineering (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

An accommodating intraocular lens, comprising: an anterior portion having an anterior viewing element; a posterior portion having a posterior viewing element, the viewing elements being positioned to move relative to each other in response to force on the intraocular lens, so as to alter the refractive power of the lens;
wherein the anterior and posterior portions comprise a single piece of material. A method of making such a lens is also provided.

Claims (30)

1. An accommodating intraocular lens, comprising:
an anterior portion having an anterior viewing element;
a posterior portion having a posterior viewing element, said viewing elements positioned to move relative to each other along an optical axis in response to action of the ciliary muscle of the eye, wherein said anterior and posterior portions comprise a single piece of material.
2. The accommodating intraocular lens of Claim 1, wherein said anterior viewing element comprises an optic having refractive power.
3. The accommodating intraocular lens of Claim 2, wherein said posterior viewing element comprises an optic having refractive power.
4. The accommodating intraocular lens of Claim 1, wherein said posterior viewing element comprises an optic having refractive power.
5. An accommodating intraocular lens, comprising:
first and second optics, at least one of said optics having refractive power, said optics mounted by an articulated frame to move relative to each other along an optical axis in response to action of a ciliary muscle, said frame formed of a single piece of material.
6. The accommodating intraocular lens of Claim 5, wherein at least one of said optics is formed of a material which is different from said material of said frame.
7. An accommodating intraocular lens, comprising:
an anterior portion having an anterior viewing element comprising an optic having refractive power;
a posterior portion having a posterior viewing element, said viewing elements positioned to move relative to each other along an optical axis in response to action of the ciliary muscle of the eye;

at least one of the anterior and posterior portions having at least one separation member with a contact surface, said at least one separation member configured to prevent contact between said anterior viewing element and said posterior viewing element by inhibiting relative movement of said anterior and posterior portions toward each other beyond a minimum separation distance;
wherein said contact surface contacts an opposing surface of said intraocular lens over a contact area when said portions are at said minimum separation distance, at least one of said surfaces having an adhesive affinity for the other of said surfaces, said contact area being sufficiently small to prevent adhesion between said surfaces when said anterior portion and said posterior portion are separated by said minimum separation distance.
8. The accommodating intraocular lens of Claim 7, wherein said contact surface and said opposing surface are comprised of the same material.
9. The accommodating intraocular lens of Claim 8, wherein said contact surface and said opposing surface are comprised of silicone.
10. The accommodating intraocular lens of Claim 7, wherein at least one of said contact surface and said opposing surface are comprised of silicone.
11. The accommodating intraocular lens of Claim 7, wherein said separation distance is about 0.1 - 1.0 mm.
12. The accommodating intraocular lens of Claim 7, wherein said separation distance is about 0.5 mm.
13. The accommodating intraocular lens of Claim 7, wherein said posterior viewing element comprises an optic having refractive power.
14. An intraocular lens comprising:
first and second interconnected viewing elements mounted to move relative to each other along an optical axis in response to action of a ciliary muscle, at least one of the viewing elements including an optic having refractive power, said lens formed by the process of:
providing a first outer mold and a second outer mold, and an inner mold therebetween, said first outer mold and said inner mold defining a first mold space, said second outer mold and said inner mold defining a second mold space;
molding said viewing elements and said optic as a single piece by filling said first and second mold spaces with a material, such that said first viewing element is formed in said first mold space and said second viewing element is formed in said second mold space;
removing said first and second outer molds from said lens while said inner mold remains between said viewing elements; and removing said inner mold from between said viewing elements while said viewing elements remain interconnected.
15. The intraocular lens of Claim 14, wherein providing said inner mold comprises molding said inner mold.
16. The intraocular lens of Claim 14, wherein providing said inner mold comprises molding said inner mold from silicone.
17. The intraocular lens of Claim 16, wherein said material comprises silicone.
18. The intraocular lens of Claim 14, wherein providing said inner mold comprises machining said inner mold.
19. The intraocular lens or Claim 18, wherein said inner mold has a first inner mold face and a second inner mold face opposite said first inner mold face, and machining said inner mold comprises machining said first inner mold face and said second inner mold face in a single piece of material.
20. A method of making an intraocular lens having first and second interconnected viewing elements, at least one of the viewing elements including an optic having refractive power, said method comprising:

providing a first outer mold and a second outer mold, and an inner mold therebetween, said first outer mold and said inner mold defining a first mold space, said second outer mold and said inner mold defining a second mold space;
molding said viewing elements and said optic as a single piece by filling said first and second mold spaces with a material, such that said first viewing element is formed in said first mold space and said second viewing element is formed in said second mold space;
removing said first and second outer molds from said lens while said inner mold remains between said viewing elements; and removing said inner mold from between said viewing elements while said viewing elements remain interconnected.
21. The method of Claim 20, wherein providing said inner mold comprises molding said inner mold.
22. The method of Claim 20, wherein providing said inner mold comprises molding said inner mold from silicone.
23. The method of Claim 22, wherein said material comprises silicone.
24. The method of Claim 20, wherein providing said inner mold comprises machining said inner mold.
25. The method of Claim 20, wherein said inner mold has a first inner mold face and a second inner mold face opposite said first inner mold face, and machining said inner mold comprises machining said first inner mold face and said second inner mold face in a single piece of material.
26. An accommodating intraocular lens, comprising:
first and second optics, at least one of said optics having refractive power, said optics mounted to move relative to each other along an optical axis in response to action of a ciliary muscle, said first optic formed of a first polymer having a number of recurring units including first-polymer primary recurring units, said second optic formed of a second polymer having a number of recurring units including second-polymer primary recurring units;
wherein no more than about 10 mole percent of the recurring units of said first polymer are the same as said second-polymer primary recurring units and no more than about 10 mole percent of the recurring units of said second polymer are the same as said first-polymer primary recurring units.
27. The accommodating intraocular lens of Claim 26, wherein at least one of said first polymer and said second polymer is selected from the group consisting of silicone, acrylic, polymethylmethacrylate, block copolymers of styrene-ethylene-butylene-styrene, styrene-base copolymers, polyvinyl alcohol, polyurethanes, hydrogels, photosensitive silicone.
28. The accommodating intraocular lens of Claim 26, wherein said first optic comprises an anterior optic, said second optic comprises a posterior optic, said first polymer comprises silicone, and said second polymer comprises acrylic.
29. The accommodating intraocular lens of Claim 26, wherein said first optic comprises an anterior optic, said second optic comprises a posterior optic, said first polymer comprises high-refractive-index silicone, and said second polymer comprises hydrophobic acrylic.
30. The accommodating intraocular lens of Claim 26, wherein said first optic comprises an anterior optic, said second optic comprises a posterior optic, said first polymer comprises silicone having a refractive index higher than about 1.43, and said second polymer comprises hydrophobic acrylic.
CA2493673A 2002-07-25 2003-07-24 Method of preparing an intraocular lens for implantation Expired - Fee Related CA2493673C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2767318A CA2767318C (en) 2002-07-25 2003-07-24 Accommodating intraocular lens system with separation member

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US10/207,717 US20030078657A1 (en) 2001-01-25 2002-07-25 Materials for use in accommodating intraocular lens system
US10/207,708 2002-07-25
US10/207,718 US20030078658A1 (en) 2001-01-25 2002-07-25 Single-piece accomodating intraocular lens system
US10/207,708 US6884261B2 (en) 2001-01-25 2002-07-25 Method of preparing an intraocular lens for implantation
US10/207,701 2002-07-25
US10/207,688 2002-07-25
US10/207,718 2002-07-25
US10/207,701 US7198640B2 (en) 2001-01-25 2002-07-25 Accommodating intraocular lens system with separation member
US10/207,717 2002-07-25
US10/207,688 US6818158B2 (en) 2001-01-25 2002-07-25 Accommodating intraocular lens system and method of making same
PCT/US2003/023077 WO2004010905A2 (en) 2002-07-25 2003-07-24 Intraocular lens system

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2767318A Division CA2767318C (en) 2002-07-25 2003-07-24 Accommodating intraocular lens system with separation member

Publications (2)

Publication Number Publication Date
CA2493673A1 true CA2493673A1 (en) 2004-02-05
CA2493673C CA2493673C (en) 2012-04-10

Family

ID=31192462

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2767318A Expired - Fee Related CA2767318C (en) 2002-07-25 2003-07-24 Accommodating intraocular lens system with separation member
CA2849167A Expired - Fee Related CA2849167C (en) 2002-07-25 2003-07-24 Intraocular lenses and methods of preparing or making same
CA2493673A Expired - Fee Related CA2493673C (en) 2002-07-25 2003-07-24 Method of preparing an intraocular lens for implantation

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA2767318A Expired - Fee Related CA2767318C (en) 2002-07-25 2003-07-24 Accommodating intraocular lens system with separation member
CA2849167A Expired - Fee Related CA2849167C (en) 2002-07-25 2003-07-24 Intraocular lenses and methods of preparing or making same

Country Status (5)

Country Link
EP (1) EP1524953A2 (en)
JP (1) JP5276762B2 (en)
AU (1) AU2003252137A1 (en)
CA (3) CA2767318C (en)
WO (1) WO2004010905A2 (en)

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CA2849167C (en) 2016-06-28
EP1524953A2 (en) 2005-04-27
CA2849167A1 (en) 2004-02-05
JP5276762B2 (en) 2013-08-28
WO2004010905A3 (en) 2004-05-13
CA2767318A1 (en) 2004-02-05
CA2493673C (en) 2012-04-10
JP2005533611A (en) 2005-11-10
WO2004010905A2 (en) 2004-02-05
CA2767318C (en) 2014-07-22
AU2003252137A1 (en) 2004-02-16

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