CA2484058A1 - Dispositif et procede destines a controler la migration des leucocytes - Google Patents

Dispositif et procede destines a controler la migration des leucocytes Download PDF

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Publication number
CA2484058A1
CA2484058A1 CA002484058A CA2484058A CA2484058A1 CA 2484058 A1 CA2484058 A1 CA 2484058A1 CA 002484058 A CA002484058 A CA 002484058A CA 2484058 A CA2484058 A CA 2484058A CA 2484058 A1 CA2484058 A1 CA 2484058A1
Authority
CA
Canada
Prior art keywords
mediator
well
leukocyte
channel
leukocyte migration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002484058A
Other languages
English (en)
Inventor
Paul Sweetnam
Matthew Brown
Bernardo Aumond
Brian Benoit
Gregory Kirk
Olivier Schueller
Emanuele Ostuni
Enoch Kim
Johanna Cruceta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Surface Logix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/206,112 external-priority patent/US6893851B2/en
Priority claimed from US10/241,445 external-priority patent/US7326563B2/en
Application filed by Surface Logix Inc filed Critical Surface Logix Inc
Publication of CA2484058A1 publication Critical patent/CA2484058A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un dispositif destiné à contrôler la migration des leucocytes. Elle concerne également un procédé mettant en oeuvre le dispositif de l'invention pour contrôler la migration des leucocytes en présence d'un écoulement de cisaillement physiologique, et ainsi simuler des états physiologiques d'un vaisseau sanguin in vivo. L'invention concerne aussi un procédé d'utilisation du dispositif pour cribler à haute capacité plusieurs substances d'essai. Elle concerne en outre un système de dosage souple et de nombreux dosages pouvant être mis en oeuvre pour tester des interactions et des systèmes biologiques. Des gradients d'écoulement laminaire sont utilisés pour simuler des situations de gradient présentes in vivo.
CA002484058A 2002-04-24 2003-04-24 Dispositif et procede destines a controler la migration des leucocytes Abandoned CA2484058A1 (fr)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US37478302P 2002-04-24 2002-04-24
US37477902P 2002-04-24 2002-04-24
US37478102P 2002-04-24 2002-04-24
US60/374,781 2002-04-24
US60/374,783 2002-04-24
US60/374,779 2002-04-24
US10/206,112 US6893851B2 (en) 2000-11-08 2002-07-29 Method for arraying biomolecules and for monitoring cell motility in real-time
US10/206,112 2002-07-29
US10/241,445 US7326563B2 (en) 2000-11-08 2002-09-12 Device and method for monitoring leukocyte migration
US10/241,445 2002-09-12
US41998002P 2002-10-22 2002-10-22
US60/419,980 2002-10-22
PCT/US2003/012764 WO2003091730A1 (fr) 2002-04-24 2003-04-24 Dispositif et procede destines a controler la migration des leucocytes

Publications (1)

Publication Number Publication Date
CA2484058A1 true CA2484058A1 (fr) 2003-11-06

Family

ID=29273928

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002484058A Abandoned CA2484058A1 (fr) 2002-04-24 2003-04-24 Dispositif et procede destines a controler la migration des leucocytes

Country Status (5)

Country Link
EP (1) EP1502108A4 (fr)
JP (1) JP2005523710A (fr)
AU (1) AU2003223722A1 (fr)
CA (1) CA2484058A1 (fr)
WO (1) WO2003091730A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050227350A1 (en) * 2004-04-13 2005-10-13 Agency For Science, Technology And Research Device and method for studying cell migration and deformation
JP2006006286A (ja) * 2004-06-29 2006-01-12 Yamatake Corp 細胞観察用チップの製造方法及び当該製造方法によって製造された細胞観察用チップ
JP2006075140A (ja) * 2004-09-13 2006-03-23 Univ Waseda 薬剤のスクリーニング方法
EP1821094A1 (fr) * 2004-12-07 2007-08-22 Effector Cell Institute, Inc. Procédé de mesure cellulaire
EP2274438A4 (fr) 2008-04-08 2013-09-11 Massachusetts Inst Technology Plate-formes microfluidiques tridimensionnelles et procédés d utilisation de celles-ci
DE102008025992B4 (de) * 2008-05-30 2011-01-27 Siemens Healthcare Diagnostics Gmbh Titerplatte und Verfahren zur Detektion eines Analyten
JP5928100B2 (ja) * 2012-03-30 2016-06-01 大日本印刷株式会社 細胞遊走試験用装置および細胞遊走試験方法
JP5910282B2 (ja) * 2012-04-20 2016-04-27 大日本印刷株式会社 細胞遊走解析方法および細胞培養物作成方法
JP6035844B2 (ja) * 2012-04-25 2016-11-30 大日本印刷株式会社 細胞遊走試験用装置および細胞遊走試験方法
WO2016132182A1 (fr) * 2015-02-20 2016-08-25 Cells For Cells Dispositifs pour l'étude de la chimiotaxie/adhérence dans des cellules faisant appel à la formation de gradients et de canaux au moyen d'hydrogels
WO2018003856A1 (fr) * 2016-06-28 2018-01-04 学校法人 慶應義塾 Plaque de micropuits pour former un réseau de gouttelettes et procédé de fabrication d'un réseau de gouttelettes
US20200041493A1 (en) * 2016-10-14 2020-02-06 StickyCell Pty Ltd Leukocyte adhesive function assays, devices and/or uses
WO2019200438A1 (fr) * 2018-04-19 2019-10-24 StickyCell Pty Ltd Recrutement de leucocytes dans une maladie infectieuse
JP7337640B2 (ja) * 2019-10-08 2023-09-04 株式会社アドバンテスト 遠心分離器および白血球量計測装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5422270A (en) * 1987-05-19 1995-06-06 The United States Of America As Represented By The Department Of Health And Human Services One-step tray test for release of soluble mediators and apparatus therefore
US5284753A (en) * 1991-03-20 1994-02-08 Neuro Probe, Inc. Multiple-site chemotactic test apparatus and method
US5460945A (en) * 1991-05-30 1995-10-24 Center For Blood Research, Inc. Device and method for analysis of blood components and identifying inhibitors and promoters of the inflammatory response
US5302515A (en) * 1992-08-20 1994-04-12 Neuro Probe, Inc. Chemotactic test apparatus and method
ATE264717T1 (de) * 1997-05-16 2004-05-15 Alberta Res Council Mikrofluidisches system und verfahren zu dessen betrieb
WO2001068131A1 (fr) * 2000-03-13 2001-09-20 Cornell Research Foundation, Inc. Inhibition de la migration des leucocytes et d'une inflammation par perturbation de cd99/hec2
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays

Also Published As

Publication number Publication date
JP2005523710A (ja) 2005-08-11
EP1502108A1 (fr) 2005-02-02
WO2003091730A1 (fr) 2003-11-06
AU2003223722A1 (en) 2003-11-10
EP1502108A4 (fr) 2007-03-21

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Legal Events

Date Code Title Description
FZDE Discontinued