CA2481227A1 - Adherent n,o-carboxymethylchitosan drug delivery devices for moist tissue and methods of their use - Google Patents

Adherent n,o-carboxymethylchitosan drug delivery devices for moist tissue and methods of their use Download PDF

Info

Publication number
CA2481227A1
CA2481227A1 CA002481227A CA2481227A CA2481227A1 CA 2481227 A1 CA2481227 A1 CA 2481227A1 CA 002481227 A CA002481227 A CA 002481227A CA 2481227 A CA2481227 A CA 2481227A CA 2481227 A1 CA2481227 A1 CA 2481227A1
Authority
CA
Canada
Prior art keywords
tissue
moist
drug
moist tissue
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002481227A
Other languages
French (fr)
Other versions
CA2481227C (en
Inventor
Clive Elson
Agis Kydonieus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kytogenics Pharmaceuticals Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2481227A1 publication Critical patent/CA2481227A1/en
Application granted granted Critical
Publication of CA2481227C publication Critical patent/CA2481227C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Abstract

The present invention relates to drug delivery devices for moist tissue, in particular mucosal tissue and tissue in the serous cavities, as well as a method of its use. The devices, which contain NOCC, are adherent to the mucosal tissue, allowing localized drug delivery. The devices are particular ly useful in vaginal, buccal and ocular devices.

Claims (26)

1. A method of providing sustained release of a drug to moist tissue comprising applying to said moist tissue a drug delivery device which is adherent to said moist tissue and includes a level of N,O-carboxymethylchitosan as a component thereof to provide said adherence, said drug delivery device further containing a sufficient quantity of the drug to be delivered to provide sustained release of said drug and permeation into said moist tissue or into the surrounding cavity.
2. The method of claim 1, wherein said moist tissue comprises mucosal tissue.
3. The method of claim 2 wherein said mucosal tissue comprises tissue of the oral cavity.
4. The method of claim 3 wherein said oral cavity tissue comprises buccal tissue.
5. The method of claim 4 wherein said drug is selected from the group consisting of melatonin, chlorpheniramine, chlorhexidine, tetracycline and mixtures thereof.
6. The method of claim 4 wherein said drug delivery device is used to treat a condition selected from the group consisting of mouth sores and periodontal disease.
7. The method of claim 4 wherein said drug delivery device is used to deliver a systemic therapeutic effect.
8. The method of claim 3 wherein said device comprises a structural support material selected from the group consisting of rubber, plastic, resin, natural and synthetic polymers, and mixtures thereof.
9. The method of claim 2 wherein said mucosal tissue comprises vaginal tissue.
10. The method of claim 9 wherein said drug is selected from a group consisting of progestins, estrogens, antifungal agents, antibacterial agents, anti-viral agents, proteins and peptides.
11. The method of claim 10 wherein said drug comprises levonorgestrel.
12. The method of claim 2 wherein said mucosal tissue comprises ocular tissue.
13. The method of claim 12 wherein said drug is selected from the group consisting of beta Mockers and glaucoma treating drugs.
14. The method of claim 2 wherein said mucosal tissue comprises the gastrointestinal tract.
15. The method of claim 1 wherein said moist tissue is tissue in a serous cavity.
16. The method of claim 15 wherein said moist tissue is tissue within the pleural, pericardial or peritoneal cavities.
17. The method of claim 1 wherein said moist tissue comprises bone.
18. A method of adhering moist tissue together comprising the steps of applying a medical device which is adherent to said moist tissue and can effect such adherence, said medical device containing N,O-carboxymethylchitosan as a component thereof.
19. The method of claim 18 wherein said medical device further comprises a tissue sealant.
20. The method of claim 18 wherein said moist tissue is at the site of a surgical incision.
21. The method of claim 19 wherein said tissue sealant comprises a fibrin glue.
22. The method of claim 19 wherein said tissue sealant comprises a cyanoacrylate.
23. The method of claim 19 wherein said tissues to be sealed are selected from the group consisting of lung tissues, heart tissues and intestinal tissue.
24. The method of claim 18 wherein said tissue adhered together comprises a defect in said moist tissue.
25. A method of preventing surgical adhesions in moist tissue comprising the steps of applying a medical device which is adherent to said moist tissue and can effect such adherence, said medical device containing N,O-carboxymethylchitosan as a component thereof, said medical device further comprising a surgical adhesion barrier.
26. The method of claim 24 wherein said surgical adhesion barrier comprises a fibrin glue.
CA2481227A 2002-03-28 2002-03-28 Adherent n,o-carboxymethylchitosan drug delivery devices for moist tissue and methods of their use Expired - Fee Related CA2481227C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/010149 WO2003082163A1 (en) 2002-03-28 2002-03-28 Adherent n,o-carboxymethylchitosan drug delivery devices for moist tissue and methods of their use

Publications (2)

Publication Number Publication Date
CA2481227A1 true CA2481227A1 (en) 2003-10-09
CA2481227C CA2481227C (en) 2012-07-31

Family

ID=28673394

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2481227A Expired - Fee Related CA2481227C (en) 2002-03-28 2002-03-28 Adherent n,o-carboxymethylchitosan drug delivery devices for moist tissue and methods of their use

Country Status (4)

Country Link
EP (1) EP1494633A4 (en)
AU (1) AU2002252565A1 (en)
CA (1) CA2481227C (en)
WO (1) WO2003082163A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2209649B1 (en) * 2002-12-09 2005-03-16 Carlos Arana Molina (Titular Al 25%) USE OF MELATONINE FOR BUCODENTAL HYGIENE FOR HUMAN AND VETERINARY USE AS AN ACTIVE PRODUCT.
EP2200674A2 (en) * 2007-09-10 2010-06-30 Boston Scientific Scimed, Inc. Medical devices with triggerable bioadhesive material
CN110731377B (en) * 2019-10-25 2022-08-30 浙江大学 Carboxymethyl chitosan-based melatonin double-layer self-assembled film and application method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888988A (en) * 1995-05-08 1999-03-30 Chitogenics, Inc. Covalently linked N,O-carboxymethylchitosan and uses thereof
CA2193149C (en) * 1995-12-22 2002-04-23 David H. Donabedian Cationic therapuetic agents and delivery systems
US6030635A (en) * 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6645947B1 (en) * 1999-05-20 2003-11-11 Chitogenics, Inc. Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins
AU2001276831A1 (en) * 2000-06-22 2002-01-02 Rxkinetix, Inc. Delivery vehicle composition and methods for delivering antigens and other drugs

Also Published As

Publication number Publication date
AU2002252565A1 (en) 2003-10-13
CA2481227C (en) 2012-07-31
EP1494633A4 (en) 2005-09-28
EP1494633A1 (en) 2005-01-12
WO2003082163A1 (en) 2003-10-09

Similar Documents

Publication Publication Date Title
US7615236B1 (en) Medical dressing for application and maintenance of medication on body tissue
RU2343903C2 (en) Mucoadhesive destroyable device of delivery of medicines for controllable administration of pharmaceutical preparations and other active bonds
EP2234652B1 (en) Mucosal tissue dressing and method of use
EP0194274B1 (en) Device for inserting in wounds and wound cavities
CA2513544C (en) An otorhinological delivery device
EP2370037B1 (en) Absorbent medical body, in particular for removing wound fluids from human and/or animal body cavities, and method for its production
ES2250681T3 (en) TISSULAR ADHESIVE APPLICATOR.
EP1263347B1 (en) System for the controlled delivery of an active material to a dental site
JPH03502053A (en) Medical equipment for body cavity introduction
JP2003517997A (en) Hemostatic polymers useful for rapid blood coagulation and hemostasis
MXPA05012564A (en) Oral treatment devices that include a thin, flexible barrier layer and an endoskeleton treatment or adhesive composition.
JPS59222406A (en) Pharmaceutical preparation for remedying periodontosis and its preparation
JP2016513532A (en) Multilayer biodegradable device with adjustable drug release profile
ES2765348T3 (en) Chitosan Stent Paste
CA2787428A1 (en) Applicator delivery tip extension
CA2481227A1 (en) Adherent n,o-carboxymethylchitosan drug delivery devices for moist tissue and methods of their use
CN1694656A (en) Apparatus for teeth cleaning and oral delivery of an agent and method of using the same
ES2267290T3 (en) METHOD FOR STERILIZING CIANOACRYLATE COMPOSITIONS.
HUP0203908A2 (en) Osmotic delivery system and method for delivery first of all of medicine
JP2006505614A (en) Dissolvable oral patch containing collagen and reticulated active ingredients
US20230404731A1 (en) Dental medicament applicator
US6780425B1 (en) Method for application and maintenance of medication on body tissue
CN213220460U (en) Wound medicine feeder
CN2271372Y (en) Esophagogastrostomy holding catheter
JP2023538536A (en) Topical and parenteral use and administration of self-assembled amphiphilic peptide hydrogels

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150330