CA2472648A1 - Process for preparing reabsorbable polyesters by mass polymerisation - Google Patents
Process for preparing reabsorbable polyesters by mass polymerisation Download PDFInfo
- Publication number
- CA2472648A1 CA2472648A1 CA002472648A CA2472648A CA2472648A1 CA 2472648 A1 CA2472648 A1 CA 2472648A1 CA 002472648 A CA002472648 A CA 002472648A CA 2472648 A CA2472648 A CA 2472648A CA 2472648 A1 CA2472648 A1 CA 2472648A1
- Authority
- CA
- Canada
- Prior art keywords
- process according
- reabsorbable
- polyester
- lactide
- containers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/78—Preparation processes
Abstract
The invention relates to a process for preparing reabsorbable polyesters by bulk polymerisation, wherein the reaction components are melted and homogenised in a stirred reactor, the reaction mixture is then transferred into a number of smaller-volume containers, the reaction mixture is polymerised in these containers and the polyester obtained is isolated by removing it from the containers, and the use of the reabsorbable polyesters thus produced for preparing reabsorbable implants.
Claims (22)
1. Process for preparing reabsorbable polyesters by bulk polymerisation, characterised in that the reaction components are melted and homogenised in a stirred reactor, the reaction mixture is then transferred into a number of smaller-volume containers, the reaction mixture is polymerised in these containers and the polyester obtained is isolated by removing it from the containers.
2. Process according to claim 1, characterised in that the polymer has an inherent viscosity of between 0.2 and 12.
3. Process according to claim 1 or 2, characterised in that the reabsorbable polyester is a polylactide or polyglycolide.
4. Process according to claim 3, characterised in that the reabsorbable polyester is poly(L-lactide).
5. Process according to claim 3, characterised in that the reabsorbable polyester is a copolymer of various stereoisomeric lactides.
6. Process according to claim 5, characterised in that the reabsorbable polyester is a copolymer of L-lactide and DL-lactide.
7. Process according to claim 3, characterised in that the reabsorbable polyester is poly(DL-lactide).
8. Process according to one of claims 1 to 3, characterised in that the reabsorbable polyester is a copolymer of glycolide and trimethylene carbonate.
9. Process according to one of claims 1 to 7, characterised in that the reabsorbable polyester is a copolymer of lactide and glycolide.
10. Process according to claim 9, characterised in that the reabsorbable polyester is a copolymer of DL-lactide or L-lactide and glycolide.
11. Process according to one of claims 1 to 7, characterised in that the reabsorbable polyester is a copolymer of lactide and trimethylene carbonate.
12. Process according to claim 1 to 7, characterised in that the reabsorbable polyester is a copolymer of lactide and .epsilon.-caprolactone.
13. Process according to one of the preceding claims, characterised in that the reabsorbable polyester is a terpolymer.
14. Process according to one of the preceding claims, characterised in that the smaller-volume containers consist of a plastic.
15. Process according to claim 14, characterised in that the smaller-volume containers consist essentially of a polyolefin.
16. Process according to claim 15, characterised in that the plastic container consists of polypropylene.
17. Process according to one of claims 1 to 14, characterised in that the plastic containers consist of a fluorinated or partially fluorinated polymer.
18. Process according to claim 17, characterised in that the plastic containers consist of polytetrafluoroethane.
19. Process according to one of the preceding claims, characterised in that the ratio of the internal volume of the stirred reactor to that of the internal volume of one of the smaller containers is between 1000:1 and 2:1.
20. Process according to one of the preceding claims, characterised in that the internal volume of the smaller container is between 50 ml and 10 litres.
21. Process according to claim 20, characterised in that the internal volume is between 100 ml and 5 litres.
22. Process for preparing reabsorbable implants, characterised in that one or more reabsorbable polyesters are prepared according to one of claims 1 to 21 and further processed to form corresponding implants.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10200738A DE10200738A1 (en) | 2002-01-11 | 2002-01-11 | Process for the preparation of resorbable polyesters by bulk polymerization |
| DE10200738.1 | 2002-01-11 | ||
| PCT/EP2003/000096 WO2003057756A1 (en) | 2002-01-11 | 2003-01-08 | Method for producing resorbable polyesters by mass polymerization |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2472648A1 true CA2472648A1 (en) | 2003-07-17 |
| CA2472648C CA2472648C (en) | 2010-12-14 |
Family
ID=7711853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2472648A Expired - Lifetime CA2472648C (en) | 2002-01-11 | 2003-01-08 | Process for preparing reabsorbable polyesters by mass polymerisation |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1468035B1 (en) |
| JP (1) | JP4975953B2 (en) |
| AR (1) | AR038286A1 (en) |
| AT (1) | ATE299156T1 (en) |
| AU (1) | AU2003206699A1 (en) |
| CA (1) | CA2472648C (en) |
| DE (2) | DE10200738A1 (en) |
| ES (1) | ES2244919T3 (en) |
| PE (1) | PE20030842A1 (en) |
| TW (1) | TW200302838A (en) |
| UY (1) | UY27611A1 (en) |
| WO (1) | WO2003057756A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11052053B2 (en) | 2018-05-08 | 2021-07-06 | Evonik Operations Gmbh | Nanoparticle comprising a bio-resorbable polyester, a hydrophilic polymer and an acylated human lactoferrin-derived peptide |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7842261B2 (en) | 2005-04-21 | 2010-11-30 | Purac Biochem Bv | Process for preparing resorbable polyesters by bulk polymerization |
| DE102007036101A1 (en) | 2007-08-01 | 2009-02-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New glycolide-rich copolymers |
| EP2030679A1 (en) * | 2007-09-03 | 2009-03-04 | Uhde Inventa-Fischer GmbH | Polymerisation reactor, polymerisation device, method for manufacturing biodegradable polyester and applications |
| WO2014108191A1 (en) | 2013-01-10 | 2014-07-17 | Evonik Industries Ag | Electronic device unit comprising a polymer coating |
| JP6312176B2 (en) | 2013-08-29 | 2018-04-18 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツングＥｖｏｎｉｋ Ｒｏｅｈｍ ＧｍｂＨ | Process for producing bioabsorbable polyester in powder form |
| EP3218422B1 (en) | 2014-11-14 | 2018-11-07 | Evonik Röhm GmbH | Process for preparing a bio-resorbable polyester in particulate form |
| CA2987209A1 (en) | 2015-06-10 | 2016-12-15 | Evonik Rohm Gmbh | Process for preparing a powder comprising a human coagulation factor protein and a lactic acid polymer |
| US20210395449A1 (en) | 2018-11-27 | 2021-12-23 | Evonik Operations Gmbh | Process for preparing a resorbable polyester as a granulate or powder by bulk polymerization |
| TW202304473A (en) | 2021-04-01 | 2023-02-01 | 美商百健Ｍａ公司 | Nucleic acid delivery to the central nervous system |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4379138A (en) * | 1981-12-28 | 1983-04-05 | Research Triangle Institute | Biodegradable polymers of lactones |
| US4643734A (en) * | 1983-05-05 | 1987-02-17 | Hexcel Corporation | Lactide/caprolactone polymer, method of making the same, composites thereof, and prostheses produced therefrom |
| DE69428583T2 (en) * | 1993-12-28 | 2002-06-27 | Dainippon Ink & Chemicals | Process for the continuous production of lactide copolymer |
| JPH10316745A (en) * | 1997-05-19 | 1998-12-02 | Tokuyama Corp | Production of poly(p-dioxanone) |
| TWI306870B (en) * | 2001-07-10 | 2009-03-01 | Kureha Corp |
-
2002
- 2002-01-11 DE DE10200738A patent/DE10200738A1/en not_active Ceased
-
2003
- 2003-01-07 UY UY27611A patent/UY27611A1/en not_active Application Discontinuation
- 2003-01-08 WO PCT/EP2003/000096 patent/WO2003057756A1/en active IP Right Grant
- 2003-01-08 AT AT03704361T patent/ATE299156T1/en active
- 2003-01-08 ES ES03704361T patent/ES2244919T3/en not_active Expired - Lifetime
- 2003-01-08 JP JP2003558067A patent/JP4975953B2/en not_active Expired - Lifetime
- 2003-01-08 CA CA2472648A patent/CA2472648C/en not_active Expired - Lifetime
- 2003-01-08 AU AU2003206699A patent/AU2003206699A1/en not_active Abandoned
- 2003-01-08 EP EP03704361A patent/EP1468035B1/en not_active Expired - Lifetime
- 2003-01-08 DE DE50300729T patent/DE50300729D1/en not_active Expired - Lifetime
- 2003-01-09 TW TW092100409A patent/TW200302838A/en unknown
- 2003-01-09 PE PE2003000034A patent/PE20030842A1/en not_active Application Discontinuation
- 2003-01-10 AR ARP030100057A patent/AR038286A1/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11052053B2 (en) | 2018-05-08 | 2021-07-06 | Evonik Operations Gmbh | Nanoparticle comprising a bio-resorbable polyester, a hydrophilic polymer and an acylated human lactoferrin-derived peptide |
Also Published As
| Publication number | Publication date |
|---|---|
| AR038286A1 (en) | 2005-01-12 |
| EP1468035B1 (en) | 2005-07-06 |
| JP4975953B2 (en) | 2012-07-11 |
| ES2244919T3 (en) | 2005-12-16 |
| PE20030842A1 (en) | 2003-11-12 |
| CA2472648C (en) | 2010-12-14 |
| JP2005514482A (en) | 2005-05-19 |
| TW200302838A (en) | 2003-08-16 |
| AU2003206699A1 (en) | 2003-07-24 |
| DE10200738A1 (en) | 2003-08-07 |
| EP1468035A1 (en) | 2004-10-20 |
| WO2003057756A1 (en) | 2003-07-17 |
| DE50300729D1 (en) | 2005-08-11 |
| ATE299156T1 (en) | 2005-07-15 |
| UY27611A1 (en) | 2003-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20230109 |