CA2469498A1 - Stable oral compositions comprising casein phosphopeptide complexes and fluoride - Google Patents

Stable oral compositions comprising casein phosphopeptide complexes and fluoride Download PDF

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Publication number
CA2469498A1
CA2469498A1 CA002469498A CA2469498A CA2469498A1 CA 2469498 A1 CA2469498 A1 CA 2469498A1 CA 002469498 A CA002469498 A CA 002469498A CA 2469498 A CA2469498 A CA 2469498A CA 2469498 A1 CA2469498 A1 CA 2469498A1
Authority
CA
Canada
Prior art keywords
safe
effective amount
fluoride
composition
oral compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002469498A
Other languages
French (fr)
Other versions
CA2469498C (en
Inventor
Cloyd Dixon, Jr.
Michael Anthony Kaminski
Timothy John Hughes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2469498A1 publication Critical patent/CA2469498A1/en
Application granted granted Critical
Publication of CA2469498C publication Critical patent/CA2469498C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to oral care compositions, especially toothpastes, comprising: a safe and effective amount of phosphopeptide-amorphous calcium phosphate complex ("PP-ACP"); a safe and effective amount of a fluoride ion source; a safe and effective amount of a phosphate buffer; a pharmaceutically-acceptable topical, oral carrier; wherein the pH of the final composition is greater than 8 to about 12 and the composition has improved fluoride stability. This invention further relates to a method of maintaining the fluoride levels in an oral care composition comprising a safe and effective amount of PP-ACP, a safe and effective amount of a fluoride ion source, and a pharmaceutically-acceptable topical, oral carrier, by adjusting the pH of the composition to greater than 8 to about 12 and by adding, to the composition, a safe and effective amount of a phosphate buffer.
CA002469498A 2002-01-03 2002-12-11 Stable oral compositions comprising casein phosphopeptide complexes and fluoride Expired - Fee Related CA2469498C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34591202P 2002-01-03 2002-01-03
US60/345,912 2002-01-03
PCT/US2002/039599 WO2003059303A2 (en) 2002-01-03 2002-12-11 Stable oral compositions comprising casein phosphopeptide complexes and fluoride

Publications (2)

Publication Number Publication Date
CA2469498A1 true CA2469498A1 (en) 2003-07-24
CA2469498C CA2469498C (en) 2009-06-02

Family

ID=23357060

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002469498A Expired - Fee Related CA2469498C (en) 2002-01-03 2002-12-11 Stable oral compositions comprising casein phosphopeptide complexes and fluoride

Country Status (7)

Country Link
US (1) US20030152525A1 (en)
EP (1) EP1461005A2 (en)
CN (1) CN1610533A (en)
AU (1) AU2002360556A1 (en)
CA (1) CA2469498C (en)
MX (1) MXPA04006541A (en)
WO (1) WO2003059303A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050089481A1 (en) * 2003-10-23 2005-04-28 Gc Corporation Composition for caries prevention
JP5000525B2 (en) * 2004-11-25 2012-08-15 ザ ユニバーシティー オブ メルボルン Stabilized calcium phosphate complex
ES2399345T3 (en) 2005-06-07 2013-03-27 The University Of Melbourne Dental mineralization
US20060280694A1 (en) * 2005-06-09 2006-12-14 John Peldyak Composition for the mineralization of dental hard tissues and the reduction of caries-inducive microflora
ES2530396T3 (en) 2005-06-24 2015-03-02 Univ Melbourne Ionic complexes
US8956594B2 (en) * 2005-10-27 2015-02-17 Ada Foundation Fluoride-calcium compositions, dental products, and methods for providing dental fluoride
WO2007089894A2 (en) * 2006-01-31 2007-08-09 Indiana University Research & Technology Corporation Materials and methods for manufacturing amorphous tricalcium phosphate and metal oxide alloys of amorphous tricalcium phosphate and methods of using the same
AR059440A1 (en) * 2006-02-09 2008-04-09 Univ Melbourne COMPOSITIONS WITH FLUORIDE AND METHODS FOR DENTAL MINERALIZATION
TWI382852B (en) * 2009-12-22 2013-01-21 Univ Taipei Medical A calcium phosphate complex for oral care applications, its preparation method, and compositions containing the same
US10111814B2 (en) * 2013-04-19 2018-10-30 National Taipei University Of Technology Desensitizing toothpaste
PL3024428T3 (en) 2013-07-23 2021-07-05 The University Of Melbourne Compositions and methods for dental mineralization
EP3086751B1 (en) 2013-12-24 2023-07-12 The University Of Melbourne Stabilized stannous compositions
BR112017006051A2 (en) * 2014-09-24 2018-05-22 The University Of Western Ontario statherin-based fusion peptide, composition, method of treatment of tooth demineralization, encapsulated enamel protective peptide or protein
JP7142943B2 (en) 2017-03-14 2022-09-28 ザ ユニバーシティー オブ メルボルン Treatment of gingivitis
EA201991935A1 (en) * 2017-03-14 2020-02-14 Де Юниверсити Оф Мельбурн SENSITIVITY TREATMENT COMPLEXES
KR101956578B1 (en) 2018-05-09 2019-03-11 주식회사 하이센스바이오 Oral care composition for alleviating dentine hyperesthesia
KR101956579B1 (en) 2018-05-09 2019-03-11 주식회사 하이센스바이오 Toothpaste composition for alleviating dentine hyperesthesia
EP3773925B1 (en) * 2018-05-21 2021-10-13 Unilever Global IP Limited Oral care composition based on calcium phosphate polyionic clusters
US20220183810A1 (en) * 2019-03-13 2022-06-16 The University Of Melbourne Concealment of hypomineralised lesions
EP3937882A4 (en) * 2019-03-13 2023-04-12 The University of Melbourne Compositions and methods for promoting mineralization

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314990A (en) * 1979-10-15 1982-02-09 The Procter & Gamble Company Toothpaste compositions
US4701319A (en) * 1984-09-14 1987-10-20 The Procter & Gamble Company Toothpaste compositions
US5015628A (en) * 1986-06-12 1991-05-14 The University Of Melbourne Anticariogenic phosphopeptides
US5227154A (en) * 1991-08-22 1993-07-13 The University Of Melbourne Phosphopeptides for the treatment of dental calculus
ATE189606T1 (en) * 1992-06-29 2000-02-15 Univ Melbourne TREATMENT OF SENSITIVE TEETH
JPH09500101A (en) * 1993-04-23 1997-01-07 ザ、プロクター、エンド、ギャンブル、カンパニー Method for producing tartar control baking soda dentifrice
KR0140248B1 (en) * 1995-03-23 1998-06-15 한상기 Novel casein phosphopeptide casein containing the said peptide and preparation method thereof
US5849269A (en) * 1996-11-26 1998-12-15 The Procter & Gamble Company Oral compositions containing fluoride, pyrophosphate, peroxide, and nonionic and/or amphoteric surfactants
AUPO566297A0 (en) * 1997-03-13 1997-04-10 University Of Melbourne, The Calcium phosphopeptide complexes

Also Published As

Publication number Publication date
MXPA04006541A (en) 2004-10-04
AU2002360556A1 (en) 2003-07-30
CN1610533A (en) 2005-04-27
CA2469498C (en) 2009-06-02
US20030152525A1 (en) 2003-08-14
WO2003059303A2 (en) 2003-07-24
WO2003059303A3 (en) 2003-12-04
EP1461005A2 (en) 2004-09-29

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