CA2469498A1 - Stable oral compositions comprising casein phosphopeptide complexes and fluoride - Google Patents

Stable oral compositions comprising casein phosphopeptide complexes and fluoride Download PDF

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Publication number
CA2469498A1
CA2469498A1 CA002469498A CA2469498A CA2469498A1 CA 2469498 A1 CA2469498 A1 CA 2469498A1 CA 002469498 A CA002469498 A CA 002469498A CA 2469498 A CA2469498 A CA 2469498A CA 2469498 A1 CA2469498 A1 CA 2469498A1
Authority
CA
Canada
Prior art keywords
safe
effective amount
fluoride
composition
oral compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002469498A
Other languages
French (fr)
Other versions
CA2469498C (en
Inventor
Cloyd Dixon, Jr.
Michael Anthony Kaminski
Timothy John Hughes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2469498A1 publication Critical patent/CA2469498A1/en
Application granted granted Critical
Publication of CA2469498C publication Critical patent/CA2469498C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to oral care compositions, especially toothpastes, comprising: a safe and effective amount of phosphopeptide-amorphous calcium phosphate complex ("PP-ACP"); a safe and effective amount of a fluoride ion source; a safe and effective amount of a phosphate buffer; a pharmaceutically-acceptable topical, oral carrier; wherein the pH of the final composition is greater than 8 to about 12 and the composition has improved fluoride stability. This invention further relates to a method of maintaining the fluoride levels in an oral care composition comprising a safe and effective amount of PP-ACP, a safe and effective amount of a fluoride ion source, and a pharmaceutically-acceptable topical, oral carrier, by adjusting the pH of the composition to greater than 8 to about 12 and by adding, to the composition, a safe and effective amount of a phosphate buffer.
CA002469498A 2002-01-03 2002-12-11 Stable oral compositions comprising casein phosphopeptide complexes and fluoride Expired - Fee Related CA2469498C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34591202P 2002-01-03 2002-01-03
US60/345,912 2002-01-03
PCT/US2002/039599 WO2003059303A2 (en) 2002-01-03 2002-12-11 Stable oral compositions comprising casein phosphopeptide complexes and fluoride

Publications (2)

Publication Number Publication Date
CA2469498A1 true CA2469498A1 (en) 2003-07-24
CA2469498C CA2469498C (en) 2009-06-02

Family

ID=23357060

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002469498A Expired - Fee Related CA2469498C (en) 2002-01-03 2002-12-11 Stable oral compositions comprising casein phosphopeptide complexes and fluoride

Country Status (7)

Country Link
US (1) US20030152525A1 (en)
EP (1) EP1461005A2 (en)
CN (1) CN1610533A (en)
AU (1) AU2002360556A1 (en)
CA (1) CA2469498C (en)
MX (1) MXPA04006541A (en)
WO (1) WO2003059303A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050089481A1 (en) * 2003-10-23 2005-04-28 Gc Corporation Composition for caries prevention
EP1827366B1 (en) * 2004-11-25 2017-03-15 The University of Melbourne Stabilized calcium phosphate complexes
JP5539648B2 (en) 2005-06-07 2014-07-02 ザ ユニバーシティー オブ メルボルン Teeth calcification
US20060280694A1 (en) * 2005-06-09 2006-12-14 John Peldyak Composition for the mineralization of dental hard tissues and the reduction of caries-inducive microflora
AR057402A1 (en) 2005-06-24 2007-12-05 Univ Melbourne CALCIUM PHOSPHATE COMPLEX STABILIZED BY PHOSPHOPEPTIDES OR PHOSPHOPROTEINS, PROCESS OF OBTAINING AND PHARMACEUTICAL COMPOSITIONS
US8956594B2 (en) * 2005-10-27 2015-02-17 Ada Foundation Fluoride-calcium compositions, dental products, and methods for providing dental fluoride
US20070178220A1 (en) * 2006-01-31 2007-08-02 Karlinsey Robert L Materials and methods for manufacturing amorphous tricalcium phosphate and metal oxide alloys of amorphous tricalcium phosphate and methods of using the same
CA2637748C (en) 2006-02-09 2015-12-08 The University Of Melbourne Compositions for dental mineralization and uses thereof
TWI382852B (en) * 2009-12-22 2013-01-21 Univ Taipei Medical A calcium phosphate complex for oral care applications, its preparation method, and compositions containing the same
US10111814B2 (en) * 2013-04-19 2018-10-30 National Taipei University Of Technology Desensitizing toothpaste
PL3024428T3 (en) 2013-07-23 2021-07-05 The University Of Melbourne Compositions and methods for dental mineralization
CN105873561B (en) 2013-12-24 2020-02-21 墨尔本大学 Stabilized stannous compositions
CN107108751A (en) * 2014-09-24 2017-08-29 西安大略大学 Saliva Statherin peptide
US20200197486A1 (en) * 2017-03-14 2020-06-25 The University Of Melbourne Complexes for treating sensitivity
ES2975419T3 (en) 2017-03-14 2024-07-05 Univ Melbourne Treatment for gingivitis
KR101956578B1 (en) 2018-05-09 2019-03-11 주식회사 하이센스바이오 Oral care composition for alleviating dentine hyperesthesia
KR101956579B1 (en) 2018-05-09 2019-03-11 주식회사 하이센스바이오 Toothpaste composition for alleviating dentine hyperesthesia
WO2019223940A1 (en) * 2018-05-21 2019-11-28 Unilever N.V. Oral care composition based on calcium phosphate polyionic clusters
US20220183810A1 (en) * 2019-03-13 2022-06-16 The University Of Melbourne Concealment of hypomineralised lesions
WO2020181334A1 (en) * 2019-03-13 2020-09-17 The University Of Melbourne Compositions and methods for promoting mineralization

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314990A (en) * 1979-10-15 1982-02-09 The Procter & Gamble Company Toothpaste compositions
US4701319A (en) * 1984-09-14 1987-10-20 The Procter & Gamble Company Toothpaste compositions
US5015628A (en) * 1986-06-12 1991-05-14 The University Of Melbourne Anticariogenic phosphopeptides
US5227154A (en) * 1991-08-22 1993-07-13 The University Of Melbourne Phosphopeptides for the treatment of dental calculus
WO1994000146A1 (en) * 1992-06-29 1994-01-06 The University Of Melbourne Treatment for sensitive teeth
JPH09500101A (en) * 1993-04-23 1997-01-07 ザ、プロクター、エンド、ギャンブル、カンパニー Method for producing tartar control baking soda dentifrice
KR0140248B1 (en) * 1995-03-23 1998-06-15 한상기 Novel casein phosphopeptide casein containing the said peptide and preparation method thereof
US5849269A (en) * 1996-11-26 1998-12-15 The Procter & Gamble Company Oral compositions containing fluoride, pyrophosphate, peroxide, and nonionic and/or amphoteric surfactants
AUPO566297A0 (en) * 1997-03-13 1997-04-10 University Of Melbourne, The Calcium phosphopeptide complexes

Also Published As

Publication number Publication date
AU2002360556A1 (en) 2003-07-30
CA2469498C (en) 2009-06-02
WO2003059303A3 (en) 2003-12-04
EP1461005A2 (en) 2004-09-29
US20030152525A1 (en) 2003-08-14
WO2003059303A2 (en) 2003-07-24
MXPA04006541A (en) 2004-10-04
CN1610533A (en) 2005-04-27

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