CA2467542A1 - Amides d'acide 1h-pyrrolo[3,2-b]pyridine-3-carboxylique - Google Patents

Amides d'acide 1h-pyrrolo[3,2-b]pyridine-3-carboxylique Download PDF

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Publication number
CA2467542A1
CA2467542A1 CA002467542A CA2467542A CA2467542A1 CA 2467542 A1 CA2467542 A1 CA 2467542A1 CA 002467542 A CA002467542 A CA 002467542A CA 2467542 A CA2467542 A CA 2467542A CA 2467542 A1 CA2467542 A1 CA 2467542A1
Authority
CA
Canada
Prior art keywords
c6alkyl
alkoxy
pyrrolo
pyridine
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002467542A
Other languages
English (en)
Inventor
George D. Maynard
Manuka Ghosh
Christopher J. O'donnell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Pfizer Products Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2467542A1 publication Critical patent/CA2467542A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des amides d'acide 1H-pyrrolo[3,2-b]pyridine-3-carboxylique qui se lient au site benzodiazépine de récepteurs GABA¿A?. De tels composés peuvent être utilisés pour moduler la liaison de ligands à des récepteurs GABA¿A? in vivo et in vitro et sont particulièrement utiles dans le traitement de divers troubles du système nerveux central chez l'homme, les animaux de compagnie domestiqués et le bétail.
CA002467542A 2001-11-19 2002-11-19 Amides d'acide 1h-pyrrolo[3,2-b]pyridine-3-carboxylique Abandoned CA2467542A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33302701P 2001-11-19 2001-11-19
US60/333,027 2001-11-19
PCT/US2002/037157 WO2003044018A1 (fr) 2001-11-19 2002-11-19 Amides d'acide 1h-pyrrolo[3,2-b]pyridine-3-carboxylique

Publications (1)

Publication Number Publication Date
CA2467542A1 true CA2467542A1 (fr) 2003-05-30

Family

ID=23300941

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002467542A Abandoned CA2467542A1 (fr) 2001-11-19 2002-11-19 Amides d'acide 1h-pyrrolo[3,2-b]pyridine-3-carboxylique

Country Status (7)

Country Link
EP (1) EP1453831A1 (fr)
JP (1) JP2005516901A (fr)
AU (1) AU2002366092A1 (fr)
BR (1) BR0214301A (fr)
CA (1) CA2467542A1 (fr)
MX (1) MXPA04004711A (fr)
WO (1) WO2003044018A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2865208B1 (fr) * 2004-01-16 2009-01-16 Sanofi Synthelabo Derives de 1,4-diazabicyclo[3.2.1]octanecarboxmique, leur preparation et leur application en therapeutique
FR2890072A1 (fr) 2005-09-01 2007-03-02 Fournier S A Sa Lab Nouveaux composesde pyrrolopyridine
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
BR112015030399B8 (pt) 2013-06-05 2023-01-10 C&C Res Lab Derivados heterocíclicos, uso dos referidos derivados e composição farmacêutica para a prevenção ou tratamento de doenças associadas com a ativação da proteína stat3
GB201317363D0 (en) 2013-10-01 2013-11-13 Eisai Ltd Novel compounds
WO2023082044A1 (fr) * 2021-11-09 2023-05-19 暨南大学 Composé amide hétérocyclique de 5-formyle et son utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750702A (en) * 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands

Also Published As

Publication number Publication date
EP1453831A1 (fr) 2004-09-08
MXPA04004711A (es) 2005-08-16
BR0214301A (pt) 2004-10-13
WO2003044018A1 (fr) 2003-05-30
JP2005516901A (ja) 2005-06-09
AU2002366092A1 (en) 2003-06-10

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20111121