CA2467131A1 - Method and apparatus for processing biological and chemical samples - Google Patents

Method and apparatus for processing biological and chemical samples Download PDF

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Publication number
CA2467131A1
CA2467131A1 CA002467131A CA2467131A CA2467131A1 CA 2467131 A1 CA2467131 A1 CA 2467131A1 CA 002467131 A CA002467131 A CA 002467131A CA 2467131 A CA2467131 A CA 2467131A CA 2467131 A1 CA2467131 A1 CA 2467131A1
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CA
Canada
Prior art keywords
support plate
assembly
target
target device
target support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002467131A
Other languages
French (fr)
Other versions
CA2467131C (en
Inventor
Xiaoxi Chen (Kevin)
Michael Shanler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corning Inc
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of CA2467131A1 publication Critical patent/CA2467131A1/en
Application granted granted Critical
Publication of CA2467131C publication Critical patent/CA2467131C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409—Sample holders or containers
    • H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0678—Facilitating or initiating evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4022—Concentrating samples by thermal techniques; Phase changes
    • G01N2001/4027—Concentrating samples by thermal techniques; Phase changes evaporation leaving a concentrated sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The subject invention provides a target support plate and an assembly of a target support plate and a target device for processing biological and chemical samples. The target support plate includes spaced-apart top and bottom surfaces, and a plurality of columns extending between, and through, the top and bottom surfaces. The target support plate may be releaseably secured to the target device by an elastomeric seal with the target support plate being at least partially formed of an elastomeric material; an adhesive; an elastomeric gasket; and/or, a mechanical fixation. The target device may be a device for collecting samples, including a multi-well plate, a mass spectrometric plate, or a secondary target support plate.

Claims (45)

1. An assembly for processing biological and chemical samples, said assembly comprising:
a target support plate having spaced-apart top and bottom surfaces, a plurality of columns extending between, and through, said top and bottom surfaces; and a target device releasably secured to said target support plate, said target device having collection sites for collecting the samples, said columns at least partially registering with said collection sites.
2. An assembly as in claim 1, wherein said target device is releasably secured to said target support plate by adhesive.
3. An assembly as in claim 1, wherein said target device is releasably secured to said target support plate by an elastomeric gasket interposed between said target support plate and said target device, said gasket being releasably adhered to said target device.
4. An assembly as in claim 3, wherein said gasket includes a silicon polymer.
5. An assembly as in claim 3, wherein said gasket includes poly(dimethyl)siloxane.
6. An assembly as in claim 1, wherein, at least said bottom surface of said target support plate is formed of an elastomeric material releasably adhered to said target device.
7. An assembly as in claim 6, wherein said elastomeric material includes a silicon polymer.
8. An assembly as in claim 6, wherein said elastomeric material includes poly(dimethyl)siloxane.
9. An assembly as in claim 6, wherein said target support plate is wholly formed of said elastomeric material.
10. An assembly as in claim 1, wherein said target device is releasably secured to said target support plate by a releasable mechanical fixation.
11. An assembly as in claim 10, wherein said target support plate includes a protruding locking member which, at least, partially bounds said target device, said locking member having an upstanding support member and a transverse member formed such that a portion of the target device is interposed between as engagement surface defined on the transverse member and said bottom surface.
12. An assembly as in claim 11, wherein said locking member is deflectable to release said target device.
13. An assembly as in claim 1, wherein, at least a portion of said columns is each formed with a cylindrical shape.
14. An apparatus as in claim 1, wherein, at least a portion of said columns is each formed with a frusto-conical shape.
15. An assembly as in claim 14, wherein said frusto-conical shaped columns are formed to converge towards said bottom surface.
16. An apparatus as in claim 1, wherein, at least a portion of said columns is each formed with non-constant cross-sections.
17. An assembly as in claim 1, wherein said bottom surface of said target support plate is recessed.
18. An assembly as in claim 17, wherein said bottom surface partially defines a recessed section defined within said target support plate, said recessed section being defined to accommodate said target device within a footprint of said target support plate.
19. An apparatus as in claim 1, wherein said target device is a multi-well plate.
20. An assembly as in claim 1, wherein said target device is a mass spectrometry plate.
21. An assembly as in claim 19, wherein said mass spectrometry is for a purpose selected from the group consisting of MALDI (Matrix-Assisted Laser Desorption Ionization) mass spectrometry, SELDI (Surface Enhanced Laser Desorption/Ionization) mass spectrometry, and DIOS (Desorption/Ionization On porous Silicon) mass spectrometry.
22. An assembly as in claim 1, wherein said target device is a secondary target support plate having spaced-apart top and bottom surfaces, a plurality of columns extending between, and through, said top and bottom surfaces, said columns of said secondary target. support plate defining said collection sites.
23. An assembly as in claim 1, wherein, at least fluid-tight seals are defined between said target support plate and said target device at locations between said collection sites so as to prevent cross-contamination between said collection sites.
24. An assembly as in claim 1, wherein, at least a portion of said columns is each provided with a filter.
25. An assembly as in claim 1, wherein, at least a portion of said columns is each provided with a filtration media.
26. An assembly as in claim 1, wherein, at least a portion of said columns is modified chemically.
27. An assembly as in claim 1, wherein, at least a portion of said columns is modified to provide reactivity for certain biological/chemical molecules.
28. An assembly as in claim 1, wherein, at least a portion of said columns is modified by physical attachment of biological/chemical entities thereto.
29. An assembly as in claim 1, wherein, at least, a portion of said columns is modified to minimize non-specific binding of various biological/chemical substances.
30. An assembly as in claim 1, wherein, at least a portion of said columns is modified to specifically bind a class of biological/chemical substances.
31. A target support plate for processing biological and chemical samples, said target support plate comprising spaced-apart top and bottom surfaces, a plurality of columns extending between, and through, said top and bottom surfaces, wherein, at least said bottom surface of said target support plate is formed of an elastomeric material which is releasably adhereable to a target device.
32. A target support plate as in claim 31, wherein said elastomeric material includes a silicon polymer.
33. A target support plate as in claim 31, wherein said elastomeric material includes poly(dimethyl)siloxane.
34. A target support plate as in claim 31, wherein said target support plate is wholly formed of said elastomeric material.
35. A target support plate assembly for processing biological and chemical samples, said assembly comprising:

a target support plate having spaced-apart top and bottom surfaces, a plurality of columns extending between, and through, said top and bottom surfaces; and means for releasably securing said target support plate to a target device such that said columns, at least, partially register with collection sites of the target device.
36. An assembly as in claim 35, wherein said means for releasably securing said target support plate is selected from the group consisting of an elastomeric gasket, an adhesive, a releasable mechanical fixation, and combinations thereof.
37. A method for processing chemical and biological liquid samples that are to be collected at collection sites on a target device, said method comprising:
releasably securing a target support plate to the target device, said target support plate having spaced-apart top and bottom surfaces, a plurality of columns extending between, and through, said top and bottom surfaces, wherein said target support plate is releasably secured to the target device such that said columns at least partially register with the collection sites of the target device; and, depositing the liquid samples in at least a portion of said columns.
38. A method as in claim 37, wherein said target support plate is at least partially formed of elastomeric material, and said releasably securing includes pressing an elastomeric portion of said target support plate into contact with the target device.
39. A method as in claim 37, wherein said releasably securing includes adhering said target support plate to the target device with adhesive.
40. A method as in claim 37, wherein said releasably securing includes releasably mechanically fixing said target support plate to the target device.
41. A method as in claim 37, wherein said releasably securing includes interposing an elastomeric gasket between said target support plate and the target device.
42. A method as in claim 37, wherein the target device is a multi-well plate.
43. A method as in claim 37, wherein the target device is a mass spectrometry plate.
44. A method as in claim 37, wherein the target device is a secondary target support plate having spaced-apart top and bottom surfaces, a plurality of columns extending between, and through, said top and bottom surfaces, said columns of said secondary target support plate defining the collection sites.
45. A method as in claim 37, wherein said releasably securing includes defining at least fluid-tight seals between said target support plate and the target device at locations between the collection sites so as to prevent cross-contamination between the collection sites.
CA2467131A 2003-05-13 2004-05-12 Method and apparatus for processing biological and chemical samples Expired - Fee Related CA2467131C (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US46998603P 2003-05-13 2003-05-13
US47002103P 2003-05-13 2003-05-13
US60/470,021 2003-05-13
US60/469,986 2003-05-13
US53891304P 2004-01-23 2004-01-23
US60/538,913 2004-01-23
US54892204P 2004-03-01 2004-03-01
US60/548,922 2004-03-01

Publications (2)

Publication Number Publication Date
CA2467131A1 true CA2467131A1 (en) 2004-11-13
CA2467131C CA2467131C (en) 2013-12-10

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Family Applications (1)

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CA2467131A Expired - Fee Related CA2467131C (en) 2003-05-13 2004-05-12 Method and apparatus for processing biological and chemical samples

Country Status (6)

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US (1) US20040228772A1 (en)
EP (2) EP1477812B1 (en)
JP (1) JP4443300B2 (en)
AU (1) AU2004202002B2 (en)
CA (1) CA2467131C (en)
DE (1) DE602004015018D1 (en)

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EP4417975A1 (en) 2016-11-30 2024-08-21 Bruker Daltonics GmbH & Co. KG Preparing live microbial samples and microorganisms for subsequent mass-specrometric measurement and evaluation
CN107376488A (en) * 2017-08-15 2017-11-24 江苏省环境监测中心 Suitable for the filtration in-situ system of the water sample containing heavy metal

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AU2004202002B2 (en) 2009-04-09
JP2004354376A (en) 2004-12-16
AU2004202002A1 (en) 2004-12-02
EP1477812A2 (en) 2004-11-17
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JP4443300B2 (en) 2010-03-31
DE602004015018D1 (en) 2008-08-28

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