CA2466234A1 - Herbal pharmaceutical compositions for prophylaxis and/or treatment of cardiovascular diseases and the method of preparing the same - Google Patents
Herbal pharmaceutical compositions for prophylaxis and/or treatment of cardiovascular diseases and the method of preparing the same Download PDFInfo
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- CA2466234A1 CA2466234A1 CA002466234A CA2466234A CA2466234A1 CA 2466234 A1 CA2466234 A1 CA 2466234A1 CA 002466234 A CA002466234 A CA 002466234A CA 2466234 A CA2466234 A CA 2466234A CA 2466234 A1 CA2466234 A1 CA 2466234A1
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- root
- rhizome
- pharmaceutical composition
- herbal pharmaceutical
- ginseng
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides an herbal pharmaceutical compositions comprising the root of scutellaria, the rhizome of coptis, the root and rhizome of rhubarb, and the dry powders of the root of ginseng (or American ginseng) or the rhizome of ginger. The herbal pharmaceutical compositions are effective in preventing patients from developing or treating patients with cardiovascular diseases, which include, but are not limited to, hypertension, coronary heart disease, cerebrovascular disease, peripheral vascular disease, heart failure, rheumatic heart disease, congenital heart disease, and cardiomyopathies. The present invention also provides methods for preparing and using the herbal pharmaceutical compositions.
Claims (42)
1. An herbal pharmaceutical compositions comprising:
an extract of Radix Scutellariae (root of scutellaria);
an extract of Rhizoma Coptidis (rhizome of coptis);
an extract of Radix et Rhizoma Rhei (root and rhizome of rhubarb); and dry powders of Radix Ginseng (root of ginseng) or Radix Panacis Quinquefolii (American ginseng);
wherein said extract of said root of scutellaria, said extract of said rhizoma of coptis, and said extract of said root and rhizome of rhubarb are produced by extracting said root of scutellaria, said rhizoma of coptis, said root and rhizome of rhubarb by a solvent which is at least one selected from the group consisting of water and alcohol.
an extract of Radix Scutellariae (root of scutellaria);
an extract of Rhizoma Coptidis (rhizome of coptis);
an extract of Radix et Rhizoma Rhei (root and rhizome of rhubarb); and dry powders of Radix Ginseng (root of ginseng) or Radix Panacis Quinquefolii (American ginseng);
wherein said extract of said root of scutellaria, said extract of said rhizoma of coptis, and said extract of said root and rhizome of rhubarb are produced by extracting said root of scutellaria, said rhizoma of coptis, said root and rhizome of rhubarb by a solvent which is at least one selected from the group consisting of water and alcohol.
2. The herbal pharmaceutical composition according to claim 1, wherein said dry powers of the root of ginseng or American ginseng is replaced with Rhizoma Zingiberis (rhizome of ginger).
3. The herbal pharmaceutical composition according to claim 1, wherein said root of scutellaria and said rhizome of coptis are extracted by water.
4. The herbal pharmaceutical composition according to claim l, wherein said root and rhizome of rhubarb is extracted by alcohol or a mixture of alcohol and water.
5. The herbal pharmaceutical composition according to claim 4, wherein said root and rhizome of rhubarb is extracted by 95 : 5 by volume of alcohol and water.
6. The herbal pharmaceutical composition according to claim l, wherein said root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said root of ginseng are at a weight ratio of about 1-2 : 1-2 : 1-2 : 1-2.
7. The herbal pharmaceutical composition according to claim 1, wherein said root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said root of ginseng or American ginseng are at a weight ratio of about 1 : 1 : 1 : 1.
8. The herbal pharmaceutical composition according to claim 2, wherein said root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said rhizome of ginger are at a weight ratio of about 1-2 : 1-2 : 1-2 : 1-2.
9. The herbal pharmaceutical composition according to claim 2, wherein said root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said rhizome of ginger are at a weight ratio of about 1 : 1 : 1 : 1.
10. The herbal pharmaceutical composition according to claim 1, wherein said herbal pharmceutical compositions is used to prevent patients from developing or treat patients with cardiovascular diseases.
11. The herbal pharmaceutical composition according to claim 10, wherein said cardiovascular diseases is at least one selected from the group consisting of hypertension, coronary heart disease, cerebrovascular disease, peripheral vascular disease, heart failure, rheumatic heart disease, congestive heart disease, and cardiomyopathies.
12. The herbal pharmaceutical composition according to claim 1, wherein said herbal pharmaceutical compositions is used to treat patients with hypertension.
13. The herbal pharmaceutical composition according to claim 1, wherein said herbal pharmaceutical compositions inhibits inducible nitric oxide synthase (iNOS).
14. The herbal pharmaceutical composition according to claim 1, wherein said herbal pharmaceutical compositions inhibits cyclooxygenase 2 (COX-2) activity.
15. The herbal pharmaceutical composition according to claim 1, wherein said herbal pharmaceutical compositions reduces C-reactive protein (CRP) concentration in serum.
16. The herbal pharmaceutical composition according to claim 1, wherein said herbal pharmaceutical compositions further comprises a pharmaceutically acceptable excipient and/or carrier.
17. The herbal pharmaceutical composition according to claim 1, wherein said herbal pharmaceutical compositions is formulated as one selected from the group consisting of granule, capsule, tablet, powder, and bolus.
18. The herbal pharmaceutical composition according to claim 17, wherein said herbal pharmaceutical composition is a tablet.
19. A method for preparing the herbal pharmaceutical composition according to claim 1 comprising:
extracting said root of scutellaria with said solvent to form said extract of root of scutellaria;
extracting rhizome of coptis with said solvent to form said extract of rhizome of coptis;
extracting said root and rhizome of rhubarb with said solvent to form said extract of said root and rhizome of rhubarb;
mixing said extracts of said root of scutellaria, said rhizome of coptis, and said root and rhizome of rhubarb to form an herbal extract mixture;
condensing said herbal extract mixture to form an herbal paste;
grinding said root of ginseng or American ginseng to make dry powders of ginseng or American ginseng;
adding said dry powders of ginseng or American ginseng to said herbal paste;
and drying said paste to form the herbal pharmaceutical composition.
extracting said root of scutellaria with said solvent to form said extract of root of scutellaria;
extracting rhizome of coptis with said solvent to form said extract of rhizome of coptis;
extracting said root and rhizome of rhubarb with said solvent to form said extract of said root and rhizome of rhubarb;
mixing said extracts of said root of scutellaria, said rhizome of coptis, and said root and rhizome of rhubarb to form an herbal extract mixture;
condensing said herbal extract mixture to form an herbal paste;
grinding said root of ginseng or American ginseng to make dry powders of ginseng or American ginseng;
adding said dry powders of ginseng or American ginseng to said herbal paste;
and drying said paste to form the herbal pharmaceutical composition.
20. The method according to claim 21, wherein said root of ginseng or American ginseng is replaced with Rhizoma Zingiberis (rhizome of ginger).
21. The method according to claim 19, wherein said root of scutellaria and said rhizome of coptis are extracted by water.
22. The method according to claim 19, wherein said root and rhizome of rhubarb is extracted by alcohol or a mixture of alcohol and water.
23. The method according to claim 19, wherein said root and rhizome of rhubarb is extracted by 95% (v/v) of alcohol in water.
24. The method according to claim 19, wherein said root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said root of ginseng or American ginseng are at a weight ratio of about 1-2 : 1-2 : 1-2 : 1-2.
25. The method according to claim 19, wherein said root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said root of ginseng or American ginseng are at a weight ratio of about 1 : 1 : 1 : 1.
26. The method according to claim 20, wherein said root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said rhizome of ginger are at a weight ratio of about 1-2 : 1-2 : 1-2 : 1-2.
27. The method according to claim 20, wherein said root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said root of ginseng or American ginseng are at a weight ratio of about 1 : 1 : 1 : 1.
28. A method for preventing patients from developing or treating patients with cardiovascular diseases comprising:
adminstering an effective amount of the herbal pharmaceutical composition according to claim 1 to said patients.
adminstering an effective amount of the herbal pharmaceutical composition according to claim 1 to said patients.
29. The method according to claim 30, wherein said herbal pharmaceutical composition is orally administered to patients.
30. The method according to claim 31, wherein said cardiovascular diseases is at least one selected from the group consisting of hypertension, coronary heart disease, cerebrovascular disease, peripheral vascular disease, heart failure, rheumatic heart disease, congenital heart disease, and cardiomyopathies.
31. A method for treating patients with hypertension comprising:
adminstering an effective amount of the herbal pharmaceutical composition according to claim 1 to said patients.
adminstering an effective amount of the herbal pharmaceutical composition according to claim 1 to said patients.
32. A method for inhibiting inducible nitric oxide synthase (iNOS) activity in patients comprising:
adminstering an effective amount of the herbal pharmaceutical composition according to claim 1 to said patients.
adminstering an effective amount of the herbal pharmaceutical composition according to claim 1 to said patients.
33. A method for inhibiting cyclooxygenase 2 (COX 2) activity in patients comprising:
adminstering an effective amount of the herbal pharmaceutical composition according to claim 1 to said patients.
adminstering an effective amount of the herbal pharmaceutical composition according to claim 1 to said patients.
34. A method for reducing serum CRP concentration in patients comprising:
adminstering an effective amount of the herbal pharmaceutical composition according to claim 1 to said patients.
adminstering an effective amount of the herbal pharmaceutical composition according to claim 1 to said patients.
35. An herbal pharmaceutical composition comprising:
dry powders of Radix Scutellariae (root of scutellaria);
dry powders of Rhizoma Coptidis (rhizome of coptis);
dry powders of Radix et Rhizoma Rhei (root and rhizome of rhubarb); and dry powders of Radix Ginseng (root of ginseng) or Radix Panacis Quinquefolii (American ginseng).
dry powders of Radix Scutellariae (root of scutellaria);
dry powders of Rhizoma Coptidis (rhizome of coptis);
dry powders of Radix et Rhizoma Rhei (root and rhizome of rhubarb); and dry powders of Radix Ginseng (root of ginseng) or Radix Panacis Quinquefolii (American ginseng).
36. The herbal pharmaceutical composition according to claim 35, wherein said root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said root of ginseng or American ginseng are at a weight ratio of about 1-2 : 1-2 :
1-2 : 1-2.
1-2 : 1-2.
37. The herbal pharmaceutical composition according to claim 35, wherein said root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said root of ginseng or American ginseng are at a weight ratio of about 1 : 1 : 1 :
1.
1.
38. The herbal pharmaceutical composition according to claim 35, wherein said root of ginseng or American ginseng is replaced with Rhizoma Zingiberis (rhizome of ginger).
39. The herbal pharmaceutical composition according to claim 35, wherein said root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said rhizome of ginger are at a weight ratio of about 1-2 : 1-2 : 1-2 : 1-2.
40. The herbal pharmaceutical composition according to claim 35, wherein said root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said rhizome of ginger are at a weight ratio of about 1 : 1 : 1 : 1.
41. A method for preparing the herbal pharmaceutical composition according to claim 35 comprising:
individually cutting and root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said root of ginseng or American ginseng into dry powders; and mixing said individually ground dry powders of root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said root of ginseng or American ginseng.
individually cutting and root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said root of ginseng or American ginseng into dry powders; and mixing said individually ground dry powders of root of scutellaria, said rhizome of coptis, said root and rhizome of rhubarb, and said root of ginseng or American ginseng.
42. The method according to claim 41, wherein said root of ginseng or American ginseng is replaced with Rhizoma Zingiberis (rhizome of ginger).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2466234A CA2466234C (en) | 2004-05-04 | 2004-05-04 | Herbal pharmaceutical compositions for prophylaxis and/or treatment of cardiovascular diseases and the method of preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2466234A CA2466234C (en) | 2004-05-04 | 2004-05-04 | Herbal pharmaceutical compositions for prophylaxis and/or treatment of cardiovascular diseases and the method of preparing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2466234A1 true CA2466234A1 (en) | 2005-11-04 |
| CA2466234C CA2466234C (en) | 2011-01-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2466234A Expired - Fee Related CA2466234C (en) | 2004-05-04 | 2004-05-04 | Herbal pharmaceutical compositions for prophylaxis and/or treatment of cardiovascular diseases and the method of preparing the same |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2466234C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526380A (en) * | 2010-12-28 | 2012-07-04 | 天津同仁堂集团股份有限公司 | Quality control method of coronary artery dredging tablet |
| CN107929482A (en) * | 2017-12-28 | 2018-04-20 | 杨杰 | A kind of medicine for treating coronary heart disease and preparation method thereof |
-
2004
- 2004-05-04 CA CA2466234A patent/CA2466234C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526380A (en) * | 2010-12-28 | 2012-07-04 | 天津同仁堂集团股份有限公司 | Quality control method of coronary artery dredging tablet |
| CN107929482A (en) * | 2017-12-28 | 2018-04-20 | 杨杰 | A kind of medicine for treating coronary heart disease and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2466234C (en) | 2011-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20170504 |