CA2465392A1 - Apparatus for delivering sensitive liquid media - Google Patents
Apparatus for delivering sensitive liquid media Download PDFInfo
- Publication number
- CA2465392A1 CA2465392A1 CA002465392A CA2465392A CA2465392A1 CA 2465392 A1 CA2465392 A1 CA 2465392A1 CA 002465392 A CA002465392 A CA 002465392A CA 2465392 A CA2465392 A CA 2465392A CA 2465392 A1 CA2465392 A1 CA 2465392A1
- Authority
- CA
- Canada
- Prior art keywords
- pressure
- container
- chamber
- outlet
- pressure chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
- A61M5/1483—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure
- A61M5/1486—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure the bags being substantially completely surrounded by fluid
Landscapes
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Fluid Mechanics (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- External Artificial Organs (AREA)
Abstract
Apparatus for delivering sensitive liquid media, such as solutions, dispersions, suspensions, and the like, which comprises at least one flexible container having an outlet and enclosing a liquid medium. A pressure chamber which accommodates the container. The outlet of the container can be led through the chamber wall. A pressure source can be connected to the pressure chamber and the pressure chamber can be pressurized thereby.
Description
__,CA 02465392 2004-04-16 .rt ..
APPARATUS FO?t2. I~EL~VERING SENSITIVE EIQL3~D ~,~~D~
H,,~.G~~'T.~~ Q,~ THE IIV~EN~ON
;, The invention relates to axa apparatus for delivering sensitive Ziquid media froxn a sealed flexible container ~~.sir~g a pressurized chamber izz which the container is held.
_ ~ Ixx kbe medical sector, it is repeafiedly z~ecessa~-y to deliver sez~sitxve liquid zxxedza sucla as solutxo~,s, dispersions, suspetzsioz~s axzd the l,ilCe, for example protein solutions, or the like. It is known to introduce the ruedia izzto ~.exible contazners and to suspend these, for e~,azz~.ple, at a specilie height, an order to supply the z~riediu~rr~ to a use, foz~ example a filtration devzce, uz~dex a positive pressure depexzdxz~g oz~ ttxe height of tb.e suspension. It is also kxZOwxz to cor~dx~c~t a gaseous rrkediuxn ixlto the container wz~a the liduid medium, to build up a positive pressure in the container anal to drive out the lxcluid ~x~~:diurn. Finally, it is known to use .
perisfialtic pumps to deliver such sez~sztive liquid media.
Disadvantages have occurred in the delivery of the liquid media. Tf the container witk~ the medium is suspended a~C a ce~ta~i.n height, then the delivery pressure depends on the difference in height between tk~e coz~taaz~ex and a user of tl~e medium. If the container ztself is inflated with a gas ix~ order to build x~p a positive pressure to deliver the liquid znedx~trn, then it is possible fox leaks in the container to occur and for the liquid mediuzxz t4 e~zierge. Even bursting of the container cannot be zuled r~ut_ Zf peristaltic pimps are used to deliver the liquid znediurn, then fzrstly sensitive constituent parts of the liquid medium are loaded naecharaical.ly by the peristaltic pump, Moreover, in particular with a love positive pressure fox delivering the liquid xxxediuz~a, it is omen a proble~xt to set a detxrted positive pressure. Fxu.alXy, pulsations occur ia~ the zx~.ediuz~x delivered, which is often uz~desired. ' -z-~LTl~!INIARY t,;33F THE ,INVENTTON
_ rt is therefore ant object ofthe inv~;ntion to provide ate apparatus fi~r d~r:.:r~riz~g sexzsitave 'liquid media which does not b,ave the above described disadvantages.
In order to achieve this object, an apparatus is proposed wh~i,c~t b,as the ;follovv~x~.g features. A, sensitive liquid mediuzxz is heid ~ a ~ea~xble contaizaer ysrith az~ outlet and .from which ~edauzz~ xs forced upon pressure be~z~,g applied to the container. Tt is distinguished by pzovxd~,g a pressure eharnber into vvhi.cb the flExible conta;tx~e~r died witlx dZe Xiquid medium can be ~~rodrxeed. ~. pressure source is conxnected to the pressuare cbawmbex, acts on the pressure c,ha~(bez' with a positive pressure and tbtez-efore cozxap~-esses the flexible container. The znediorn is thereby driven out of the container. It is particularly advantageous.that ~e pressure can be set very accurately and can be easily zz~oz~itored.
BRT~F DESCR1PTTON O~ ~ DR.A°W7NG
'xhe invention is axpl.axx~ed in morE detail in the follo~riz~g text using the dzawxz~g, rwhicb, zs a perspective view of a pressure chamber forxxzed as a pzessuxe cabinet.
~ET~iL.ED DESCRIPTION Op .~,~.'~,tE~ERRED E1V1BODT~EN~~?,~ ~'HE
1N~E
The pressure cabiuaet 1. shown in the single Figure has ata, interior which serves as a pxesswue chamber 3, into whzch there zs introduced a flexible container 5 in which there is a sensitive Iicluid xxzediu~xi '~.
-.~- ~.~ ..w Thte cox~taiz~er S ;is preferably formed as a sterile disposable bag, which is tbexefnxe used only once, so the pm'blenas of clearaxxg axed disitl:fecd.on of the coz~tazz~ejc which are associated with xe~,Xling are avoided.
The -container S has an outlet 9, from wluich a hose 1 Z exits. The Iaose discharges the liquid x~aedi:7 from the container 5. OthErwise, the corxtaituex is closed off completely .from the outside, so that the ~m,edxum 7 cannot be contaminated.
The coz~taxxxex S is suspended in the interior of the pressure cabinet 1 in a suitable way. Here, it is illustrated with a eonwentxoz~al. cutout 13, which is provided in a double~walled region of the coa~taiz~ez~ 5, so that there no connection is pxovi,ded betwee~ot the liquid znediurn 7 and the outside. Two hoofs 1 S, ur~.ch hold the coz~taaz~er 5 securely izx the ztzterior of the pressure cabinet l, engabe in ~e cutout 23.
However, such. a suspension of the container S is necessary only when the pressure cabinet 1 is operated upright, rxrlxich should be the norcaal. case.
However, should the cabinet be oriented horizontal, tlxe eonta.xz~ex S would be held securely by the side walls 1,7, 19, 21 and 23, so that further hxiug oftkze container 5 in the pressure chamber 3 would not be xeduired.
The hooks 15 can be fixed to a rear urall 25 ofthe pressure cabizzet l, ar else &ozxa the znside to tlae upper side wall 17. It is merely critical that tlae coz~taiz~er 5 is held in a desired positxoz~ lae~re, so that it dOES not kink the hose 11 ozx account ofthe inherent weight of the coxztaartex.
'1"he lower side wall 21 of tlae cabinet has a cutout 27, whick~ leads from the pressure chamber 3 to the outside and accoodates the hose 3.1.
Preferably, aza elastic pxotectiwe layer, far example a rubber gronet z9, prevents the hose l l chaf ng through.
Fitfed to oxte side wall 23, for example via hinges 33 and 35, oz the like, is a door 31 which when closed, closes o~~tla.e pzessuxe clza~xxbez~ 3 in a pressure-tight warmer.
' On its side ~acizxg tlxe pressure chamber 3, the dooz may be provided with a cireumferential seal 37, whzch ixxteracts wzth the frozrt sides of the side ~tvalls 17, 19, 21 a»d 23 to close off the pressux9e chamber 3 in a pressure-tight manner.
- Ora the bottom of the door 31., a protective layer 38 z~aay again be p~rovitded, which holds tlxe bole 11 secuxely in the cutout 27 without chafinb trough it.
Oz~ ane side wall, here wall 19, there is a pressuxe conxzection 39, via whiel; the pressure chamber 3 cue. be eoxsneeted at 40 to a pressure source 42.
When tb,e door 31 is closed, the presslue so~~zce caix place da.e pzessure chamber 3 and tk~exe~ox~e a1~4 fibs ~lexxble container 5 under a positive pzessure. Also provided on the side wall 19 are a. pressure indicator 4.T and a safety valve 43.
Finally, the appazatus 1 catz also be pro~~ided with a vibrati~ag uzzit, Eo ensuxe that the xnedxum 7 present in the container 5 can be Dept cozxtir~~xously moving or during predetezminable time periods, in order tv avoid settling c~f the substances present in the rraediuna.
'~'he vibzating unit can act directly on the contaznez S a~zd can be arccommodated in the pressure chazxuber 3. Idowever, fibs pressure cabinet '1 is preferably placed on a vibrating table .~4 atxd tkzerefore subjected in its entirety to a xn.ovetnent -~rbich acts on the medium 7 in the container 5, In the follawiz~g test, operahion of the apparatus for delivering sensitive liquid na~edxa will be described in more detail:
In the container 5 there is a sez~sztive zx~edxum., ~or example a svlutzon, dispersion or suspezzsion, which should not bE subjected to any rrxechanzcal - S - '"~= . .
loading as might be provided, fox exaxxlpla, when the rnediuzxz is pnrnped with a peristaltic prop.
The cox~ta,~z~~ex 5 itself is at least az~ pazt of flexible material, so t3aat a positive pressure acting on the contaiu~.ex 5 acts on the liduid xnediuzn 7 inside the container and drives t.~te ~xa.edium out via the outlet 9 and the hose 11.
The container 5 is ix~~hroduced into the interior of the pressure cabxz~et l, that is into tx~.e pressure chamber 3, and zs preferably fixed to the hooks I 5.
The hose .2 ~ is led through the cutout 27, which is diznex~siox~ed such that tb~e hose 1 I
is not crushed when the door 31 is closed. The hose 11 zu~ay consist of a flexible materiaX which closes off the cutout ,27 xx~ a pressure-tight ~xzaaaxa.ez.
however, pxovisiozz is preferably made here far a protective xayer ~9, which interacts with the protective layer 38 vn the door' 31 in such a way that, v~rhez~ 'the door is closed, the hose 11 is enclosed completely and the pressure chaxnbez 3 is closed off pressaaxe-tight from the outside. In ad.ditioz~, the seal 37 interacts with the side walls 17, 19, 21 anal 23 heze, so that ~Cbe pressure chaxnbex 3 is closed off completely when the door 31 is closed-'Then, a positive pressure is built up in the ix~tezzox of the appazatus, here in the pressure cabinet l, through tb.e pzessure coz~x~ection 39. A
gasea~us medium is preferably conducted into the pressure chaxnbex 3, sia~ce such a medium.
escapes duiekly when the door 31 is opened. However, it would also bE
conceivab.le to enz~duct a liduid zoedium into the chaxz~ber 3, since the pressure xnediurxi is isolated by the coz~taaz~ez 5 fxozx~ the liduid n~.ediuxx~ 7 i~ the int~;rEOr of the contaixaex.
Nitrogen is pzefexably conducted into the pressure chamber 3 fxozn the source 42, since would not impair the seztsi.tzwe znediuxn 7 in the inteziaz of the container 5, even in the event of azxy leaks in the container.. In addition, the iz~sxde of the pressure cabinet x is not contazxzinated by this gas.
y S r ~ s:~ . .., T$e positive pressure acting i7a the pressure chatmber 3 can be set by a xnonitaring device in tez7ms of level and in terns of the pressure vax~atxo~x ' provided over time. For this purpose, suitable backing up of the pressure source can be provided. ~onitozix~.g of the pressure chamber 3 caza. be arazpleroez~ted by a zaaz~uitor~g device which inchxdes the pressure indicator 41 and the safety valve ~.3.
The valve prevents a hazardous positive pressure in the pressure chamber 3 apd therefore prevents the door 3r burst; open undesirably. However, it is particularly important that the medium 7 is discharged fxozxx the coxttainer S only at a defined pressure aa~d that is roil-hazardous for the medium 7 axtd fox its processing.
The safety valve 43 preferably can be set to a desired pressure, xra.
order to employ the apparatus readily for various delivery purposes. Fox example, when hlterixxg sensitive xnedza, a filtration pressure of about U.2 bar is used.
,A.ccordingay, the safety valve 43 zx~l~st then be~ set to this pressure, in ozder to enable use of the apparatus for filtering.
In principle, it is therefore possible, by use of are appropriate monitoring device and with adjustable pressure sources, to maintain a desired pressure in the pressure chamber 3 or else to xnaintazn. diffezez~t pressure values at different times. The apparatus can therefore be exnployed urAiversally, that is to say z~ot just fox f hexing xoedia but fox various processing and delivery puucposes, and possibly also as a metering device whey, administering medicaments.
in the embodiment illustrated, the pressure chamber 3 is designed to accommodate a single coxrtaiz~er 5. However, it its possible to subdivide the pressure chamber axzd to allocate different pressure values to v~ous regions of the pressure chamber which are delirnixed from one another in a pressure-tight xnanl~ex~, anal also possible to accorxunodate dif~e~rent containers in these regions.
It is critical that the medium 7 can be delivered a:nd discharged frozzu the container 5 without contact. pressure acting externally on the flexible W' . . ., container S delivers the xttedium 7 out of the container S via tlae outlet 9 axxd the hose 11 and supplites znediumi to various untended 'uses.
'l he pressuxe cha~z»ber 3 is not brought ixxto contact with filxe medium 7, so that the replacement of containers with different media is easily possible, without need for a complicated disixxfection process. The media from different containers dci not eozne into contact with either the interior or the pressure chau~ber of the pressure cabinet nor with any appliances coxmected to the pressure chamber, here filae px-essure connectxaxt 39, tl~e pressure ~dxcator 41 ox the safet~r valve 43. ~f the pressure chamber 3 is preferably acted on with nitrogen at a positive pressure, it is possible to ensure that the rneditzrn 7 is not impaired, even if the con~taxxxer 5 should have a leaky point and the pressure medium sJhould penetrate into the interior of the cozttaix~er S.
After all this, it is obvious that the apparatus is constreicted very sirrzply and therefore can operate virtually without fault. 'this leads to very safe use of the apparatus described here, which as of critical zxnportance izr pazticulsx ixx the medical sector.
,. lu order to be able to employ the apparatus even at very low positive pressure values, the presswre cormection 3~ can also be provided with s.
pressure red~uci~.g valve. This leads to additional safety if the apparatus, foz e~anaple, is used zn a fZltration in which a positive prESSUre of only 0.~ bar is desired.
The re~,uirerrzexrts for the container 5 are in no way special. It is possible to use usual sterile disposable: bags such as are on the market. No kind of adaptation of the coz~'~nex zs therefore requiz'ed duz7.rxg its use ire the apparatus described here.
Even izr the case wl;en the medium rrxust to be kept moving continuously, no special precautions are z~equired here, 'fhe pressu~ce cabinet X ca:~ be placed vn conventional vibrati~ag tables, which then act on the medium 7 with the . .x Jg, .._ vibrating znowezx~exat. Since the pressuxe cabinet 1, as constructed very simply and x~.ggedly, no detz~ux~.ent to xt ase to be expected when a ~.bz~atzng, tabXe is used.
Aithotzgh the pxesent nn~vention has been described zn xelation to paxticulax eznbodiz~aezzts thez~eof, many okher v~xnatxons and modifications and othez uses will become apparent to tb,ose skilled ix~. the aat. ~t i.s pz'eferx'ed, therefore, that the present invention be limited not by the specific disclosure b.ez-~zzzy but only by the appended claixn,s. .
APPARATUS FO?t2. I~EL~VERING SENSITIVE EIQL3~D ~,~~D~
H,,~.G~~'T.~~ Q,~ THE IIV~EN~ON
;, The invention relates to axa apparatus for delivering sensitive Ziquid media froxn a sealed flexible container ~~.sir~g a pressurized chamber izz which the container is held.
_ ~ Ixx kbe medical sector, it is repeafiedly z~ecessa~-y to deliver sez~sitxve liquid zxxedza sucla as solutxo~,s, dispersions, suspetzsioz~s axzd the l,ilCe, for example protein solutions, or the like. It is known to introduce the ruedia izzto ~.exible contazners and to suspend these, for e~,azz~.ple, at a specilie height, an order to supply the z~riediu~rr~ to a use, foz~ example a filtration devzce, uz~dex a positive pressure depexzdxz~g oz~ ttxe height of tb.e suspension. It is also kxZOwxz to cor~dx~c~t a gaseous rrkediuxn ixlto the container wz~a the liduid medium, to build up a positive pressure in the container anal to drive out the lxcluid ~x~~:diurn. Finally, it is known to use .
perisfialtic pumps to deliver such sez~sztive liquid media.
Disadvantages have occurred in the delivery of the liquid media. Tf the container witk~ the medium is suspended a~C a ce~ta~i.n height, then the delivery pressure depends on the difference in height between tk~e coz~taaz~ex and a user of tl~e medium. If the container ztself is inflated with a gas ix~ order to build x~p a positive pressure to deliver the liquid znedx~trn, then it is possible fox leaks in the container to occur and for the liquid mediuzxz t4 e~zierge. Even bursting of the container cannot be zuled r~ut_ Zf peristaltic pimps are used to deliver the liquid znediurn, then fzrstly sensitive constituent parts of the liquid medium are loaded naecharaical.ly by the peristaltic pump, Moreover, in particular with a love positive pressure fox delivering the liquid xxxediuz~a, it is omen a proble~xt to set a detxrted positive pressure. Fxu.alXy, pulsations occur ia~ the zx~.ediuz~x delivered, which is often uz~desired. ' -z-~LTl~!INIARY t,;33F THE ,INVENTTON
_ rt is therefore ant object ofthe inv~;ntion to provide ate apparatus fi~r d~r:.:r~riz~g sexzsitave 'liquid media which does not b,ave the above described disadvantages.
In order to achieve this object, an apparatus is proposed wh~i,c~t b,as the ;follovv~x~.g features. A, sensitive liquid mediuzxz is heid ~ a ~ea~xble contaizaer ysrith az~ outlet and .from which ~edauzz~ xs forced upon pressure be~z~,g applied to the container. Tt is distinguished by pzovxd~,g a pressure eharnber into vvhi.cb the flExible conta;tx~e~r died witlx dZe Xiquid medium can be ~~rodrxeed. ~. pressure source is conxnected to the pressuare cbawmbex, acts on the pressure c,ha~(bez' with a positive pressure and tbtez-efore cozxap~-esses the flexible container. The znediorn is thereby driven out of the container. It is particularly advantageous.that ~e pressure can be set very accurately and can be easily zz~oz~itored.
BRT~F DESCR1PTTON O~ ~ DR.A°W7NG
'xhe invention is axpl.axx~ed in morE detail in the follo~riz~g text using the dzawxz~g, rwhicb, zs a perspective view of a pressure chamber forxxzed as a pzessuxe cabinet.
~ET~iL.ED DESCRIPTION Op .~,~.'~,tE~ERRED E1V1BODT~EN~~?,~ ~'HE
1N~E
The pressure cabiuaet 1. shown in the single Figure has ata, interior which serves as a pxesswue chamber 3, into whzch there zs introduced a flexible container 5 in which there is a sensitive Iicluid xxzediu~xi '~.
-.~- ~.~ ..w Thte cox~taiz~er S ;is preferably formed as a sterile disposable bag, which is tbexefnxe used only once, so the pm'blenas of clearaxxg axed disitl:fecd.on of the coz~tazz~ejc which are associated with xe~,Xling are avoided.
The -container S has an outlet 9, from wluich a hose 1 Z exits. The Iaose discharges the liquid x~aedi:7 from the container 5. OthErwise, the corxtaituex is closed off completely .from the outside, so that the ~m,edxum 7 cannot be contaminated.
The coz~taxxxex S is suspended in the interior of the pressure cabinet 1 in a suitable way. Here, it is illustrated with a eonwentxoz~al. cutout 13, which is provided in a double~walled region of the coa~taiz~ez~ 5, so that there no connection is pxovi,ded betwee~ot the liquid znediurn 7 and the outside. Two hoofs 1 S, ur~.ch hold the coz~taaz~er 5 securely izx the ztzterior of the pressure cabinet l, engabe in ~e cutout 23.
However, such. a suspension of the container S is necessary only when the pressure cabinet 1 is operated upright, rxrlxich should be the norcaal. case.
However, should the cabinet be oriented horizontal, tlxe eonta.xz~ex S would be held securely by the side walls 1,7, 19, 21 and 23, so that further hxiug oftkze container 5 in the pressure chamber 3 would not be xeduired.
The hooks 15 can be fixed to a rear urall 25 ofthe pressure cabizzet l, ar else &ozxa the znside to tlae upper side wall 17. It is merely critical that tlae coz~taiz~er 5 is held in a desired positxoz~ lae~re, so that it dOES not kink the hose 11 ozx account ofthe inherent weight of the coxztaartex.
'1"he lower side wall 21 of tlae cabinet has a cutout 27, whick~ leads from the pressure chamber 3 to the outside and accoodates the hose 3.1.
Preferably, aza elastic pxotectiwe layer, far example a rubber gronet z9, prevents the hose l l chaf ng through.
Fitfed to oxte side wall 23, for example via hinges 33 and 35, oz the like, is a door 31 which when closed, closes o~~tla.e pzessuxe clza~xxbez~ 3 in a pressure-tight warmer.
' On its side ~acizxg tlxe pressure chamber 3, the dooz may be provided with a cireumferential seal 37, whzch ixxteracts wzth the frozrt sides of the side ~tvalls 17, 19, 21 a»d 23 to close off the pressux9e chamber 3 in a pressure-tight manner.
- Ora the bottom of the door 31., a protective layer 38 z~aay again be p~rovitded, which holds tlxe bole 11 secuxely in the cutout 27 without chafinb trough it.
Oz~ ane side wall, here wall 19, there is a pressuxe conxzection 39, via whiel; the pressure chamber 3 cue. be eoxsneeted at 40 to a pressure source 42.
When tb,e door 31 is closed, the presslue so~~zce caix place da.e pzessure chamber 3 and tk~exe~ox~e a1~4 fibs ~lexxble container 5 under a positive pzessure. Also provided on the side wall 19 are a. pressure indicator 4.T and a safety valve 43.
Finally, the appazatus 1 catz also be pro~~ided with a vibrati~ag uzzit, Eo ensuxe that the xnedxum 7 present in the container 5 can be Dept cozxtir~~xously moving or during predetezminable time periods, in order tv avoid settling c~f the substances present in the rraediuna.
'~'he vibzating unit can act directly on the contaznez S a~zd can be arccommodated in the pressure chazxuber 3. Idowever, fibs pressure cabinet '1 is preferably placed on a vibrating table .~4 atxd tkzerefore subjected in its entirety to a xn.ovetnent -~rbich acts on the medium 7 in the container 5, In the follawiz~g test, operahion of the apparatus for delivering sensitive liquid na~edxa will be described in more detail:
In the container 5 there is a sez~sztive zx~edxum., ~or example a svlutzon, dispersion or suspezzsion, which should not bE subjected to any rrxechanzcal - S - '"~= . .
loading as might be provided, fox exaxxlpla, when the rnediuzxz is pnrnped with a peristaltic prop.
The cox~ta,~z~~ex 5 itself is at least az~ pazt of flexible material, so t3aat a positive pressure acting on the contaiu~.ex 5 acts on the liduid xnediuzn 7 inside the container and drives t.~te ~xa.edium out via the outlet 9 and the hose 11.
The container 5 is ix~~hroduced into the interior of the pressure cabxz~et l, that is into tx~.e pressure chamber 3, and zs preferably fixed to the hooks I 5.
The hose .2 ~ is led through the cutout 27, which is diznex~siox~ed such that tb~e hose 1 I
is not crushed when the door 31 is closed. The hose 11 zu~ay consist of a flexible materiaX which closes off the cutout ,27 xx~ a pressure-tight ~xzaaaxa.ez.
however, pxovisiozz is preferably made here far a protective xayer ~9, which interacts with the protective layer 38 vn the door' 31 in such a way that, v~rhez~ 'the door is closed, the hose 11 is enclosed completely and the pressure chaxnbez 3 is closed off pressaaxe-tight from the outside. In ad.ditioz~, the seal 37 interacts with the side walls 17, 19, 21 anal 23 heze, so that ~Cbe pressure chaxnbex 3 is closed off completely when the door 31 is closed-'Then, a positive pressure is built up in the ix~tezzox of the appazatus, here in the pressure cabinet l, through tb.e pzessure coz~x~ection 39. A
gasea~us medium is preferably conducted into the pressure chaxnbex 3, sia~ce such a medium.
escapes duiekly when the door 31 is opened. However, it would also bE
conceivab.le to enz~duct a liduid zoedium into the chaxz~ber 3, since the pressure xnediurxi is isolated by the coz~taaz~ez 5 fxozx~ the liduid n~.ediuxx~ 7 i~ the int~;rEOr of the contaixaex.
Nitrogen is pzefexably conducted into the pressure chamber 3 fxozn the source 42, since would not impair the seztsi.tzwe znediuxn 7 in the inteziaz of the container 5, even in the event of azxy leaks in the container.. In addition, the iz~sxde of the pressure cabinet x is not contazxzinated by this gas.
y S r ~ s:~ . .., T$e positive pressure acting i7a the pressure chatmber 3 can be set by a xnonitaring device in tez7ms of level and in terns of the pressure vax~atxo~x ' provided over time. For this purpose, suitable backing up of the pressure source can be provided. ~onitozix~.g of the pressure chamber 3 caza. be arazpleroez~ted by a zaaz~uitor~g device which inchxdes the pressure indicator 41 and the safety valve ~.3.
The valve prevents a hazardous positive pressure in the pressure chamber 3 apd therefore prevents the door 3r burst; open undesirably. However, it is particularly important that the medium 7 is discharged fxozxx the coxttainer S only at a defined pressure aa~d that is roil-hazardous for the medium 7 axtd fox its processing.
The safety valve 43 preferably can be set to a desired pressure, xra.
order to employ the apparatus readily for various delivery purposes. Fox example, when hlterixxg sensitive xnedza, a filtration pressure of about U.2 bar is used.
,A.ccordingay, the safety valve 43 zx~l~st then be~ set to this pressure, in ozder to enable use of the apparatus for filtering.
In principle, it is therefore possible, by use of are appropriate monitoring device and with adjustable pressure sources, to maintain a desired pressure in the pressure chamber 3 or else to xnaintazn. diffezez~t pressure values at different times. The apparatus can therefore be exnployed urAiversally, that is to say z~ot just fox f hexing xoedia but fox various processing and delivery puucposes, and possibly also as a metering device whey, administering medicaments.
in the embodiment illustrated, the pressure chamber 3 is designed to accommodate a single coxrtaiz~er 5. However, it its possible to subdivide the pressure chamber axzd to allocate different pressure values to v~ous regions of the pressure chamber which are delirnixed from one another in a pressure-tight xnanl~ex~, anal also possible to accorxunodate dif~e~rent containers in these regions.
It is critical that the medium 7 can be delivered a:nd discharged frozzu the container 5 without contact. pressure acting externally on the flexible W' . . ., container S delivers the xttedium 7 out of the container S via tlae outlet 9 axxd the hose 11 and supplites znediumi to various untended 'uses.
'l he pressuxe cha~z»ber 3 is not brought ixxto contact with filxe medium 7, so that the replacement of containers with different media is easily possible, without need for a complicated disixxfection process. The media from different containers dci not eozne into contact with either the interior or the pressure chau~ber of the pressure cabinet nor with any appliances coxmected to the pressure chamber, here filae px-essure connectxaxt 39, tl~e pressure ~dxcator 41 ox the safet~r valve 43. ~f the pressure chamber 3 is preferably acted on with nitrogen at a positive pressure, it is possible to ensure that the rneditzrn 7 is not impaired, even if the con~taxxxer 5 should have a leaky point and the pressure medium sJhould penetrate into the interior of the cozttaix~er S.
After all this, it is obvious that the apparatus is constreicted very sirrzply and therefore can operate virtually without fault. 'this leads to very safe use of the apparatus described here, which as of critical zxnportance izr pazticulsx ixx the medical sector.
,. lu order to be able to employ the apparatus even at very low positive pressure values, the presswre cormection 3~ can also be provided with s.
pressure red~uci~.g valve. This leads to additional safety if the apparatus, foz e~anaple, is used zn a fZltration in which a positive prESSUre of only 0.~ bar is desired.
The re~,uirerrzexrts for the container 5 are in no way special. It is possible to use usual sterile disposable: bags such as are on the market. No kind of adaptation of the coz~'~nex zs therefore requiz'ed duz7.rxg its use ire the apparatus described here.
Even izr the case wl;en the medium rrxust to be kept moving continuously, no special precautions are z~equired here, 'fhe pressu~ce cabinet X ca:~ be placed vn conventional vibrati~ag tables, which then act on the medium 7 with the . .x Jg, .._ vibrating znowezx~exat. Since the pressuxe cabinet 1, as constructed very simply and x~.ggedly, no detz~ux~.ent to xt ase to be expected when a ~.bz~atzng, tabXe is used.
Aithotzgh the pxesent nn~vention has been described zn xelation to paxticulax eznbodiz~aezzts thez~eof, many okher v~xnatxons and modifications and othez uses will become apparent to tb,ose skilled ix~. the aat. ~t i.s pz'eferx'ed, therefore, that the present invention be limited not by the specific disclosure b.ez-~zzzy but only by the appended claixn,s. .
Claims (9)
1. An apparatus for delivering liquid media, comprising at least one flexible container which has an outlet and encloses a liquid medium, a pressure chamber which accommodates the container and from which the outlet from the container can be led, and a pressure source connection to the pressure chamber by which the pressure chamber can be pressurized,
2. The apparatus as claimed in claim 1, further comprising a pressure source to the pressure source connection and the source acts on the pressure chamber with nitrogen.
3. The apparatus as claimed in claim 1, further comprising a monitoring device operable for setting a defined pressure or for setting a defined pressure variation over time.
4. The apparatus as claimed in claim 1, wherein the container is a bag.
5. The apparatus as claimed in claim 1, wherein the container is a sterile disposable bag.
6. The apparatus as claimed in claim 1, further comprising a vibrating unit positioned and operable to act on the medium to be discharged from the container.
7. The apparatus as claimed in claim 6, wherein the vibrating unit includes a vibrating table on which the pressure chamber may be arranged.
8. The apparatus as claimed in claim 1, further comprising a device in the chamber which supports the container so as to not block the exit of medium through the outlet.
9. The apparatus as claimed in claim 1, further comprising an outlet conduit from the container outlet and a sealable passage from the chamber through which the outlet conduit passes to outside the chamber while the chamber is sealed.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10319874.1 | 2003-05-03 | ||
| DE10319874A DE10319874B3 (en) | 2003-05-03 | 2003-05-03 | Dispenser for fluid solutions has flexible bag with outlet mounted in outer pressure chamber with nitrogen supply to force contents out of bag |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2465392A1 true CA2465392A1 (en) | 2004-11-03 |
Family
ID=32731173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002465392A Abandoned CA2465392A1 (en) | 2003-05-03 | 2004-04-16 | Apparatus for delivering sensitive liquid media |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20040232171A1 (en) |
| EP (1) | EP1475112A1 (en) |
| JP (1) | JP2004329925A (en) |
| CA (1) | CA2465392A1 (en) |
| DE (1) | DE10319874B3 (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPR867901A0 (en) | 2001-11-05 | 2001-11-29 | University of Newcastel Research Associates Limited, The | 'Liquid dispenser' |
| US20050011582A1 (en) * | 2003-06-06 | 2005-01-20 | Haug Jeffrey S. | Fluid delivery system for a flow cytometer |
| US7731678B2 (en) | 2004-10-13 | 2010-06-08 | Hyprotek, Inc. | Syringe devices and methods for mixing and administering medication |
| WO2006103489A1 (en) * | 2005-04-01 | 2006-10-05 | Malak Jean Clement Edouard Ghi | Device for the injection of a medical liquid by means of hyperbaric infusion |
| WO2007056773A2 (en) | 2005-11-09 | 2007-05-18 | Hyprotek, Inc. | Syringe devices, components of syringe devices, and methods of forming components and syringe devices |
| US8002737B2 (en) | 2007-10-04 | 2011-08-23 | Hyprotek, Inc. | Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers |
| US9522097B2 (en) | 2007-10-04 | 2016-12-20 | Hyprotek, Inc. | Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers |
| FR3003644B1 (en) | 2013-03-22 | 2015-03-20 | Sartorius Stedim North America Inc | CHECKING THE FREEZING STATE OF A BIOPHARMACEUTICAL FLUID IN A CONTAINER. |
| FR3003550B1 (en) | 2013-03-22 | 2016-05-06 | Sartorius Stedim North America Inc | SYSTEM AND METHOD FOR PREPARING A CHARGED CONTAINER WITH A BIOPHARMACEUTICAL FLUID. |
| FR3009964B1 (en) * | 2013-09-02 | 2015-11-20 | Remi Giordanengo | DEVICE FOR THE MANAGEMENT OF IRRIGATION FLUIDS, ESPECIALLY FOR ENDOSCOPY. |
| CN104874048A (en) * | 2015-04-01 | 2015-09-02 | 上海司太立制药有限公司 | Flexibly packaged medicine liquid injection device and flexibly packaged medicine liquid injection method |
| DE102018103866A1 (en) * | 2018-02-21 | 2019-08-22 | Fresenius Medical Care Deutschland Gmbh | Device containing a dialysis solution |
| EP3628356B1 (en) * | 2018-09-26 | 2021-12-22 | Erbe Elektromedizin GmbH | Medical instrument and creation device |
| CN113456928B (en) * | 2021-07-08 | 2023-04-07 | 广州友沃医疗设备有限公司 | Push type high-pressure syringe |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL180493C (en) * | 1977-09-02 | 1987-03-02 | Oordt & Co Holding Bv | METHOD FOR DOUBLE-WALLED, Airtight Packaging of Foodstuffs |
| US5060826A (en) * | 1988-08-25 | 1991-10-29 | Fabricated Metals, Inc. | Container with inflatable vessel for controlling flow of liquid or viscous material |
| US5163909A (en) * | 1991-01-28 | 1992-11-17 | Alan E. Jordan | Medical fluid delivery system |
| DE4137748A1 (en) * | 1991-11-15 | 1993-05-19 | Schiwa Gmbh | Pressure container for compressing liq.-filled bag - delivers pharmaceutical liq. at controlled pressure |
| DE4208656C2 (en) * | 1992-03-18 | 1995-07-20 | L & H Lemiteg Lebensmittel Und | Airtight lockable food storage container |
| GB2298933B (en) * | 1992-07-13 | 1996-11-13 | Pall Corp | Automated system and method for processing biological fluid |
| EP0600754A3 (en) * | 1992-12-03 | 1995-05-24 | Kato Hatsujo Kaisha Ltd | Constant pharmaceutical infuser. |
| IT1260685B (en) * | 1993-09-29 | 1996-04-22 | Sorin Biomedica Spa | BLOOD CONTAINMENT DEVICE |
| CA2163968C (en) * | 1994-04-06 | 2006-05-16 | Prakash R. Keshaviah | Method and apparatus for a tidal oscillating pulse peritoneal dialysis |
| US5792109A (en) * | 1994-09-01 | 1998-08-11 | Leland L. Ladd | Irrigation pump and system |
| US5497912A (en) * | 1994-10-20 | 1996-03-12 | Hoback; Michael W. | Disposable self-dispensing pressurized package for delivery of sterile fluids |
| FR2750053B1 (en) * | 1996-06-21 | 1999-01-15 | Saphir Medical Sa | BI-FUNCTION FLOW AND / OR PRESSURE GENERATOR-DISTRIBUTOR |
| US6027488A (en) * | 1998-06-03 | 2000-02-22 | Genetronics, Inc. | Flow-through electroporation system for ex vivo gene therapy |
| US20010035184A1 (en) * | 1999-12-17 | 2001-11-01 | Carlos Schuler | Systems and methods for treating packaged powders |
-
2003
- 2003-05-03 DE DE10319874A patent/DE10319874B3/en not_active Expired - Lifetime
-
2004
- 2004-04-02 EP EP04008033A patent/EP1475112A1/en not_active Withdrawn
- 2004-04-16 CA CA002465392A patent/CA2465392A1/en not_active Abandoned
- 2004-04-27 JP JP2004130755A patent/JP2004329925A/en active Pending
- 2004-04-30 US US10/835,992 patent/US20040232171A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040232171A1 (en) | 2004-11-25 |
| EP1475112A1 (en) | 2004-11-10 |
| JP2004329925A (en) | 2004-11-25 |
| DE10319874B3 (en) | 2004-08-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2465392A1 (en) | Apparatus for delivering sensitive liquid media | |
| JP5662800B2 (en) | Self-contained portable device for drug administration | |
| KR100886983B1 (en) | Device for the dosed delivery of a fluid | |
| US3895741A (en) | Intravenous fluids administration apparatus | |
| TWI229002B (en) | Fluid dispenser with stabilized fluid flow | |
| CA2401559C (en) | Method of and apparatus for cultivating a cell or tissue | |
| US5492534A (en) | Controlled release portable pump | |
| WO2001003757A3 (en) | Medical fluid delivery system | |
| KR102672435B1 (en) | Device for preserving blood products and cell cultures in gaseous media under pressure | |
| JPH11507285A (en) | Apparatus and method for limiting free flow in an injection system | |
| JPS60501790A (en) | fluid supply device | |
| JPS63164962A (en) | Pressure injection apparatus | |
| JPH04218148A (en) | Stone crusher | |
| US10682211B1 (en) | Mixing system and a method of preparing an oral care composition | |
| US8313475B2 (en) | Liquid dispenser | |
| KR101905698B1 (en) | Implantable drug infusion pump for supporting full-duplex communication and system using the same | |
| JPS61164564A (en) | Automatic solution injector | |
| JP2019000421A (en) | Liquid supply device | |
| US3720240A (en) | Method of preparing intravenous feeding containers | |
| EP0600754A2 (en) | Constant pharmaceutical infuser | |
| AU2008309614B2 (en) | Self-contained portable apparatus for administration of a drug solution | |
| GB2564651B (en) | Medical gas supply system | |
| US20190009973A1 (en) | Canister Device for Producing Sclerosing Foam | |
| JPS59189857A (en) | Fluid injecting apparatus and method | |
| SU1664330A1 (en) | Portable respiratory device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |