CA2463491A1 - Magnetic field enhancement of tumor treatment - Google Patents
Magnetic field enhancement of tumor treatment Download PDFInfo
- Publication number
- CA2463491A1 CA2463491A1 CA002463491A CA2463491A CA2463491A1 CA 2463491 A1 CA2463491 A1 CA 2463491A1 CA 002463491 A CA002463491 A CA 002463491A CA 2463491 A CA2463491 A CA 2463491A CA 2463491 A1 CA2463491 A1 CA 2463491A1
- Authority
- CA
- Canada
- Prior art keywords
- tumor
- magnetic field
- free radical
- created
- free radicals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract 16
- 230000005291 magnetic effect Effects 0.000 title claims abstract 10
- 238000000034 method Methods 0.000 claims abstract 17
- 238000005215 recombination Methods 0.000 claims abstract 2
- 230000006798 recombination Effects 0.000 claims abstract 2
- 150000003254 radicals Chemical class 0.000 claims 13
- 230000005670 electromagnetic radiation Effects 0.000 claims 4
- 239000013043 chemical agent Substances 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 239000006249 magnetic particle Substances 0.000 claims 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/002—Magnetotherapy in combination with another treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
- A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
- A61N1/406—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia using implantable thermoseeds or injected particles for localized hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Magnetic Treatment Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A method of treating a tumor, comprising creating an elevated concentration of free radicals in said tumor (22) and creating a magnetic field (20) that traverses said tumor (22) and that inhibits the recombination of said free radicals in said tumor. A magnetic field of 0.1 mTesla to 10 mTesla is generally used for this purpose.
Claims (16)
1. A method of treating a tumor, comprising:
(a) creating an elevated concentration of free radicals in said tumor; and (b) creating a magnetic field that traverses said tumor and that inhibits the recombination of said free radicals in said tumor.
(a) creating an elevated concentration of free radicals in said tumor; and (b) creating a magnetic field that traverses said tumor and that inhibits the recombination of said free radicals in said tumor.
2. The method of claim 1, wherein said free radicals are created in said tumor by means of electromagnetic radiation.
3. The method of claim 2, wherein said electromagnetic radiation is in the frequency band from 10 Hz to 10 20 Hz.
4. The method of claim 2, wherein said electromagnetic radiation is in the frequency band from 2*10 14 to 10 15Hz.
5. The method of claim 2, wherein said electromagnetic radiation is applied to said tumor in conjunction with the introduction of a chemical agent.
6. The method of claim 1, wherein said free radicals are created in said tumor by means of the introduction of a chemical agent.
7. The method of claim 1, wherein said magnetic field is of a magnitude that facilitates the interstate crossing of singlet state free radical pairs to triplet state free radical pairs.
8. The method of claim 1, wherein said magnetic field has a magnitude in. the range of 0.1 Tesla to 10 milli Tesla through said tumor.
9. The method of claim 1, wherein said magnetic field is of a magnitude that inhibits the interstate crossing of triplet state free radical pairs to singlet state free radical pairs.
10. The method of claim 1, wherein said magnetic field is created by at least one magnet positioned exterior to said tumor.
11. The method of claim 1, wherein said magnetic field is created by magnetic particles that are injected into proximity to said tumor.
12. The method of claim 1, wherein said elevated concentration of free radical pairs is created by sound waves.
13. The method of claim 1, wherein said elevated concentration of free radical pairs is created by acoustic cavitation.
14. The method of claim 1, wherein said free radicals interfere with the operation of enzymes within said tumor cells.
15. The method of claim 1, where free radical magnetic effects are contoured, scaled or designed to conform to tumor volume or shape.
16. The method of claim 1, where free radical reactivity is enhanced by introducing electromagnetic shielding to block ambient electromagnetic interference.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32808501P | 2001-10-11 | 2001-10-11 | |
| US60/328,085 | 2001-10-11 | ||
| US34927002P | 2002-01-18 | 2002-01-18 | |
| US60/349,270 | 2002-01-18 | ||
| PCT/US2002/032444 WO2003030722A2 (en) | 2001-10-11 | 2002-10-09 | Magnetic field enhancement of tumor treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2463491A1 true CA2463491A1 (en) | 2003-04-17 |
| CA2463491C CA2463491C (en) | 2011-07-26 |
Family
ID=26986208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2463491A Expired - Lifetime CA2463491C (en) | 2001-10-11 | 2002-10-09 | Magnetic field enhancement of tumor treatment |
Country Status (4)
| Country | Link |
|---|---|
| AU (1) | AU2002343495A1 (en) |
| CA (1) | CA2463491C (en) |
| GB (1) | GB2396302B (en) |
| WO (1) | WO2003030722A2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2855067B1 (en) | 2003-05-20 | 2005-06-24 | Emery Sa | SNOW SURF MOUNTING |
| CN107362445A (en) * | 2017-08-30 | 2017-11-21 | 东北师范大学 | Anticancer targeting medicine points to electrostatic field resultant vector intensifier |
| EP3727579B1 (en) * | 2017-12-19 | 2021-10-06 | Medical Development Technologies S.A. | Heatable implant device for tumor treatment |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3163724D1 (en) * | 1980-04-29 | 1984-06-28 | Electro Biology Inc | Apparatus for treating an intact animal organism bearing a neoplastic process and undergoing drug treatment |
| US5156587A (en) * | 1983-09-01 | 1992-10-20 | Montone Liber J | Method for treating malignant cells |
| US4665898A (en) * | 1984-05-23 | 1987-05-19 | Maxwell Laboratories, Inc. | Malignancy treatment |
| AU6639596A (en) * | 1995-07-28 | 1997-02-26 | James R. Gray | Use of a polarizing field to modify the efficacy of a bioactive agent |
| US6261831B1 (en) * | 1999-03-26 | 2001-07-17 | The United States Of America As Represented By The Secretary Of The Air Force | Ultra-wide band RF-enhanced chemotherapy for cancer treatmeat |
-
2002
- 2002-10-09 CA CA2463491A patent/CA2463491C/en not_active Expired - Lifetime
- 2002-10-09 GB GB0408373A patent/GB2396302B/en not_active Expired - Lifetime
- 2002-10-09 WO PCT/US2002/032444 patent/WO2003030722A2/en not_active Application Discontinuation
- 2002-10-09 AU AU2002343495A patent/AU2002343495A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| GB2396302B (en) | 2006-05-31 |
| CA2463491C (en) | 2011-07-26 |
| WO2003030722A2 (en) | 2003-04-17 |
| GB2396302A (en) | 2004-06-23 |
| GB0408373D0 (en) | 2004-05-19 |
| WO2003030722A3 (en) | 2003-07-03 |
| AU2002343495A1 (en) | 2003-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20221011 |