CA2458528C - Indane-1-ones substitues en c2 et leurs derives, leur procede de production et leur utilisation en tant que medicaments - Google Patents
Indane-1-ones substitues en c2 et leurs derives, leur procede de production et leur utilisation en tant que medicaments Download PDFInfo
- Publication number
- CA2458528C CA2458528C CA2458528A CA2458528A CA2458528C CA 2458528 C CA2458528 C CA 2458528C CA 2458528 A CA2458528 A CA 2458528A CA 2458528 A CA2458528 A CA 2458528A CA 2458528 C CA2458528 C CA 2458528C
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- cycloalkyl
- replaced
- cooh
- fluorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
L'invention concerne des indane-1-ones substitués en C2, leurs sels physiologiquement acceptables et leurs dérivés physiologiquement fonctionnels. L'invention se rapporte à des composés de formule (I), dans laquelle les groupes sont tels que définis dans la description, ainsi qu'à leurs sels physiologiquement acceptables et à leur procédé de production. Ces composés constituent par exemple des anorexigènes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10142722A DE10142722A1 (de) | 2001-08-31 | 2001-08-31 | C2-substituierte Indan-1-one und ihre Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE10142722.0 | 2001-08-31 | ||
PCT/EP2002/009207 WO2003020677A2 (fr) | 2001-08-31 | 2002-08-17 | Indane-1-ones substitues en c2 et leurs derives, leur procede de production et leur utilisation en tant que medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2458528A1 CA2458528A1 (fr) | 2003-03-13 |
CA2458528C true CA2458528C (fr) | 2011-01-25 |
Family
ID=7697277
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2458528A Expired - Fee Related CA2458528C (fr) | 2001-08-31 | 2002-08-17 | Indane-1-ones substitues en c2 et leurs derives, leur procede de production et leur utilisation en tant que medicaments |
Country Status (12)
Country | Link |
---|---|
US (1) | US6762326B2 (fr) |
EP (1) | EP1425267B1 (fr) |
JP (1) | JP4280164B2 (fr) |
AR (1) | AR036675A1 (fr) |
AT (1) | ATE472525T1 (fr) |
AU (1) | AU2002336085B2 (fr) |
CA (1) | CA2458528C (fr) |
DE (2) | DE10142722A1 (fr) |
IL (1) | IL160608A0 (fr) |
MX (1) | MXPA04001846A (fr) |
PE (1) | PE20030360A1 (fr) |
WO (1) | WO2003020677A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9920393D0 (en) | 1999-08-27 | 1999-11-03 | Medix Scient Uk Limited | Plant extract mixtures and their uses |
US7659313B2 (en) | 2007-09-13 | 2010-02-09 | Gateway Health Alliances, Inc. | Methods and related compositions using specific indanes to reduce weight and inhibit lipase, α-amylase and α-glucosidase activity in mammals |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7700500L (sv) * | 1976-01-20 | 1977-07-21 | Hoechst Ag | Tiazolidinderivat och forfarande for deras framstellning |
DE2640358A1 (de) * | 1976-09-08 | 1978-03-16 | Hoechst Ag | Thiazolidinderivate und verfahren zu ihrer herstellung |
DE2965279D1 (en) * | 1978-07-27 | 1983-06-01 | Schering Ag | Indanyl derivatives, process for their preparation and pharmaceutical compositions containing these compounds |
WO1989003681A1 (fr) * | 1987-10-19 | 1989-05-05 | Pfizer Inc. | Tetralines, chromans et composes relatifs substitues destines au traitement de l'asthme |
DE69317399T2 (de) * | 1993-01-29 | 1998-07-02 | American Cyanamid Co | Aminocycloalkanobenzodioxole als beta-3 selektive adrenergische Wirkstoffe |
DK0865419T3 (da) * | 1995-12-06 | 2003-11-10 | Venantius Ltd | Dimere indanforbindelse og farmaceutiske anvendelser heraf |
IL125071A0 (en) | 1996-01-17 | 1999-01-26 | Novo Nordisk As | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives their preparation and use |
HU227021B1 (en) | 1996-08-30 | 2010-05-28 | Novo Nordisk As | Glp-1 derivatives |
JP4339402B2 (ja) | 1996-12-31 | 2009-10-07 | ドクター・レディーズ・ラボラトリーズ・リミテッド | 新規なヘテロ環化合物、これらの製造方法及びこれらを含有する薬学的組成物、並びに糖尿病及び関連疾患の治療におけるこれらの使用 |
CA2294830A1 (fr) | 1997-07-16 | 1999-01-28 | John Bondo Hansen | Derives de 1,2,4-thiadiazine fusionnee, leur preparation et utilisation |
DE19831878C2 (de) * | 1998-07-17 | 2001-05-17 | Aventis Pharma Gmbh | Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE19844547C2 (de) * | 1998-09-29 | 2002-11-07 | Aventis Pharma Gmbh | Polycyclische Dihydrothiazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE19908539A1 (de) * | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische 2-Amino-Dihydrothiazolsysteme, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
FR2796070B1 (fr) * | 1999-07-06 | 2003-02-21 | Lipha | Derives de benzodiazepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparation |
EP1078632A1 (fr) | 1999-08-16 | 2001-02-28 | Sanofi-Synthelabo | Utilisation des inhibiteurs de monoamine oxydases dans la fabrication d'un médicament contre l'obésité |
-
2001
- 2001-08-31 DE DE10142722A patent/DE10142722A1/de not_active Withdrawn
-
2002
- 2002-08-17 IL IL16060802A patent/IL160608A0/xx unknown
- 2002-08-17 EP EP02769973A patent/EP1425267B1/fr not_active Expired - Lifetime
- 2002-08-17 AU AU2002336085A patent/AU2002336085B2/en not_active Ceased
- 2002-08-17 DE DE50214511T patent/DE50214511D1/de not_active Expired - Lifetime
- 2002-08-17 CA CA2458528A patent/CA2458528C/fr not_active Expired - Fee Related
- 2002-08-17 AT AT02769973T patent/ATE472525T1/de active
- 2002-08-17 JP JP2003524950A patent/JP4280164B2/ja not_active Expired - Fee Related
- 2002-08-17 WO PCT/EP2002/009207 patent/WO2003020677A2/fr active Application Filing
- 2002-08-17 MX MXPA04001846A patent/MXPA04001846A/es active IP Right Grant
- 2002-08-22 PE PE2002000806A patent/PE20030360A1/es not_active Application Discontinuation
- 2002-08-29 AR ARP020103245A patent/AR036675A1/es unknown
- 2002-08-30 US US10/231,326 patent/US6762326B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6762326B2 (en) | 2004-07-13 |
CA2458528A1 (fr) | 2003-03-13 |
DE10142722A1 (de) | 2003-03-27 |
JP4280164B2 (ja) | 2009-06-17 |
WO2003020677A3 (fr) | 2003-07-31 |
JP2005525295A (ja) | 2005-08-25 |
PE20030360A1 (es) | 2003-05-16 |
US20030130345A1 (en) | 2003-07-10 |
AU2002336085B2 (en) | 2007-10-11 |
WO2003020677A2 (fr) | 2003-03-13 |
AR036675A1 (es) | 2004-09-29 |
DE50214511D1 (de) | 2010-08-12 |
IL160608A0 (en) | 2004-07-25 |
EP1425267B1 (fr) | 2010-06-30 |
ATE472525T1 (de) | 2010-07-15 |
EP1425267A2 (fr) | 2004-06-09 |
MXPA04001846A (es) | 2004-06-15 |
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CA2458528C (fr) | Indane-1-ones substitues en c2 et leurs derives, leur procede de production et leur utilisation en tant que medicaments | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |